Document ExwqpVgLmVL4Na8zaXQJrZjq4

y `SSuummmmaarryy PPFFOOSS OOrraall RRaatt TTooxxiiccoollooggyy SSecrreeeenn `SSttuaddyyNNiimmbbeerrss;: 33MM --TT--66229955,, NNOTOOXT--22O442299X3333,, 33MM AAnanlytaicall --FFyAACCtTT--iTTOOcXX--1a12200l3.3 `Compound; Perfaorooctan sulfonate, poassum slt (CFSOK) Compound: Perfluorooctane sulfonate, potassium salt (CsF~TSO~K) `PtSSFttBouudSdxyy,TiTiPicdFtlHeeoStolaxonicdogPloRygO:yS: (pEEoxxsppilltooirrvaaettcooorrynyt22o88l--)DDaabyyyDOOarriaalll yTToGoraxivcictaiygtyeSiSntuyhdyeRwwaiittthh FTToeellllooommweeerrdbAAyllcoaobhe1oll,,TTe4 elDlooammyeR2 erreAcAcorcv8 ryyellraaytte,, Period PFBS, Period PFHS and PFOS (positive control) by Daily Garage in the Rat Followed by a 14/28-Day Recovery `TSSettuluddoyymTeTriitAleceraaynlnaatlyiet,iacPaFl::BSRR,eepPpooFrrHttSooffDaDnadtataPafFfooOrrSEExpxlpolorraattoorryy2288--DDaayyOOrarall TToosxciciittyy SStuuddyy wwiitthh TTeelloommeerr AAllccoohhooll,, Telomer Acrylate, PFBS. PFHS and PFOS ReportDates: 27 Apel 1999 (toxicoloagny)d 11 June 1999 (nalytical) Report Dates: 27 April 1999 (toxicology) and 11 June 1999 (analytical) `SStutddyMMonointiotorrss: MMaarrvviinn CCaasseeaanndd PPaauull LLiieeddeerr `SSdttuouddsyyeSoSufumm3mmmaarrpsy:/AAkgggrfoour/rp2ood8ffdo1aa14y4symmu.aaTllhepaeannnddB11e44xffeewmmeaarlleernraaecttsrrorpeesccieeeiivdveseddnttdhhtehcceoormmepmpoaouiunnndid,n,gppoossstietiixvvaeencicoomninartlroosll,,otoreraralellldyyaatt raresdceooxevsaeefrtoycefprpe3efromroiiuogord/wvk(e(gpne/oodekratsyraeomfraoftemrrne2eyc)8not.vd)e.arTyTys.hh.rerTAehe/sseeienmxiw8wle/aserregrexernowneueeccprrroeoofnppessci1ier4dodspeaafsftitreeeadrrttstawwnsodowtweheeeekerkseasmsovocfaofirnnreetienccrgooovlv6esed/arrsyyneaxdanwnaeddnrtitmehheeaarlrsreememlanyaiteidnnroieisnndeggd `Cw3wl/iiisttnehhixcvvaaeelfhhtiieiccrgllfeeso---uwr11ew6%raeeaeqhqkuuuseneoocoufhusresecdccpaoaorvrsbbetooruyxxry.yemmiAenettshh(iymywlloilccafeerelllmgularlooloeusssp.e.doufri1n4g/stehxe rats st served as controls and were orally to weofeeaktesn; onemale dosed had usCswwrloiionlnlilglceeatnnlhaasibbsgddenoocsmomwneedennhreddauulhrrfuiinonngcgfhwlleeaadssatttpefmoeewswntutddr.aaeyyAissnoottfwhftetorreeefanaettmdmmeoaenfltnet.tsh. edFF2ueer8mmindaagalleyethsbbeooolfddacyystowwtmweepiiogoghhuwttnsesdewwkedrseemroeifsnsitiirggetnnaiaitfftmiiicceaoannnnttt;,llyoythnrreeeemddmeuuaccsleeeddhad afdfneeuimmrmaianallglesbtbhohoeadddysyercwweoedeniuigdgchhehttdassblwwfoeoedrfryeetwr,Lee!,ai1t1gm22h..et33ng%%t.a..iAnHHto--owtwmheaeevlveeeernsr,d,ddouuf1rrt0iihn.eng8t2%tah8hendd2a2y88f-s-eddomaaafyylcreroeesmccooLpvvoe1eur4rnyy.pd5pe%aredriimoeosddi,n,tibbhsoaotrnttahhctmimooanlan,leetsshaoe.ndmd Teffehaemnemsaaellee bdabonoadidrmyyiawnwl4esgeg%hihgwathdefterfeekefdfcouetccfstesdeccabooortrrdceeyllntawteedeadinsgsdhooftmmegemeawaiwlineti-sthhhmrraeeadddleuurscceee,d!d,du1cff0oeo.do8cdd%ocncoaosnnnusdmsuupmfmtpeimtpoitanoilonednsusra,s1is,mn1mgs4at.e5lhes%eshhla3ea%dsds4rrt1eehdddau4unccceeowddnecctoeronoknslsssuu.ommfpTtphiteioosnen during 4~ week of treatment and females had reduced consumption during the 3ra and 4th weeks of HhHtreeeemamamttmaaoteltonoloogt.ilgciocaalgcldihdaadanatlageiinsndddiiuccrattieendd sstliihgghhrtlelcyyollvoeowrwyHHpeeotrtivvoaadlluuieenffeooitrfhfeeermmsaealxle.essBtalttothhoeedeebninoddcohofefmttirreseatatrtmmyeevnnattl..ueTTshheesrrheeowwweeerrdeebnnoooth dehrrceeerddmeuuacacteesoddelodccghhtiooclolaeellssptcteerhrroaootnllegaiaennnsadtdnrturidirggginlllygoycbcteuherleiridrineedavcaetaotlvttuheehersyweehpniedcrooihnoffd2r26ei8n-sd-uddelaaittyyehdewtirreenasaeutamxm.eeninBtntcloiirnoeadtthshbeeedimAomacIalhGleeesms..aisTTt.rhhyeeTvmmhaalealulreeesessdhhsuhaacdodewlsdlieigdghhbttlolyyth dccvahhelooculrleeeesssa,ttseeearrdlootllthoaaotnnuaddgl hptirrsigotgaytlteyciicsneteriarcidnaddleelrygerlecsociobgovnuveilerfinireecdavdnaatalf,ufetewerser rcwceoohmmwicpphioouruiennsdduhilrttsrectedaoarttiimmnceaealnnntctoisnsntttcoorrppeoppaleesvddea.d.luASSecc/saGatatitredearrteeiwodde. ortTethhhneroerbtrbiceiooodcncuhshceieemdmdieicrcaealdl bibvroeialollauoltoegegsid,i:ccoaaalblltmhemeorauenagbniihnionscggthfafeutumilsli..tciTcaThalhlelecyhrraseeinddgguuneccisfeewiddcecachrnhoteol,nelwoeststet.ereerroowllaiatnhndidntihrgiilgsytloyerceireciraiddl ecvovanaltluruoeelssvwwaeleurreeescoaoannsdsiiwddeeerrreeddnttoootbbceoecncosoimdmpeporeoudunndd arA`eAnttldnanetreececdrlr;aootoppitsvshyeyear(af5bfetierobrco22hd88eydmdawaiyceysasiolgocfhfhccaoionvmmgeperpsoowuwuenneidrdgehaatnddsommtii.nninidsiistctraratatitiinoognn,i,nmmcaraellaeeseaadnnddifvfeeermmaialzleeea.anniTimmhaeallfssehhmaaaddleicsnrcaerleasaosseheddadaabbisnsocolrluuetateesed dkauKnriididdnnnregeeyytlahwwteeieviige2gh8h(t-%tssd..abyRRodreeeyvcveowrveseeairrlgoyhosftpf)taetrlhhliievoediirn.ncwcrMreeeiaiacgssrheeodtdssclliionvvpderiirccwwaeeteiiniggxghhiitasnsc((mrde3&a&isoe9dnf))livaaavneneddtrr sKkseiiiizdcdetnno.ieeoyyTnsnshswwereefeieigvgmhehtaltssleed((s2ha))elsddpoiaiddthnonacodoytttiooencccccrueurarsed maydhlyuepriesnprgatrtnohepdeho2yn8rli-nydbpaboatyortttrhhieascrsleoelxyxveeersosreysaotptlptehuhreteieoioedhnnn.oddcMooycfifuctrrrroeieesadsctmitonnpmetitncht..eRRxfeaoecmcmoolvinveeaerstrdiyyoounofrftiohtnfhigliisstvmhmeiercficsroerouocsstrcicoowonppsiiccreeccovhhefacaarnnlegegcedkeovhideeidsdrpynan.toootcoyoctccecuurriinntthhee HoHmiviassrltoeiopsspaa,atnthhpdlaonoolcognrgileyicacaspal,al reestxxipaalalmmelyieinnnraeattsteiiosootlinnust,wwioaaannssdoddctocohnuyenrmrouoeensnd.ssineellteehccetteefddekmkeeayyloeosrrgdgataannSssn-g- adrenals, Kidoeys, the four weeks of adrenals, kidneys, iver, ymph recovery. liver, lymph nnooddeess,, `aoAAnvffdaterr3ire722s788,dppdapaanymyfcooroferfaddfso,eosmssiaipnnllgegeser.rneel,laatDtetuiisvrvtieeislln,yygabhniridgeghchtohvlyeeemvvreylulsssP.oFoffOPSPFFlOOiSvSewrweleervreeeplprsredesisedendntetcinnitntheheebuliitvveetrrt-~hmemeeeaannndooofff 44211899dppappymmsffooofrrmmalaleess Faencdon3e7r7yptphme mfoerafnemeavleess. wDeruerinsigllre2c3o7veprpymPfFoOr mSallievseralnedve1ls91dpidpmdfecolrifneembaulet sa.t the end of 28 days of recovery the mean levels were still 237ppm for males and 191ppm for females. C`Cwoohnniccclhluusssieioornvnses:d: aTsThhitishse22p88s-iddiaayvyesscccrroeeneetnnoalatt 33inmmtghg/i/skkgog/r/addlaayytwowxaiacssistsyuusffcffeiccceinenin:ntgtoostddoeedmmyo.onsntsTrthraaetteeetfthfheeectttsooxxiiincccleeuffdffeeccdttssLobofofPdPOyFOSS,, `wpwwreheoiiingcoghhuth,sn,e,c1rb,evbldelodoioonaddtschtchehhmoeolaleplesosetsteriatroiosvll,e, tc1h'olalinnivtvreneorrsl hsiiiznezeet,fh,eaiasmnnaoddlrheaheleapptsoaa.xttoioccPciyetyytriesshihcysyrtpepeeenerncrritenroowgpphashysty.ui.dnTydTh.ihecTeasstheeeeedfeefbffefyfecectlctsatsscwkwieonerfcrrleuessdcooeommdveee,w1rw,hybohaoatfdtymmvooerrree pronounced in the male rats than in the female rats. Persistence TehfefercatsoarnadlaNcOkoELfcwoamspo<u3ndmcgle.arance fromthe ier effects and lack of compound clearance from the liver. was indicated by lack of recovery of liver The rat oral NOEL was < 3 mg/kg. 33MM PPrroo`ppOrrciiteeottbaaerrryy II1nn9ff9oo9rrmmaattiioonn October 1999 Exhibit sete16n1,7 ce `CHCEOONNNNFFEIIDPDEIENNNTTCIIAOALLUN-- STSUUYBBDJJIEESCCTTTRITTCOOT AACOPPURRROOTT,TEECNCTOT,IIVV2EE7-OOCRRV-DD1EE0RR.2E8E8NN6TT2EERREEDD IN IN HENNEPIN COUNTY DISTRICT COURT, NO. 27-CV-10-28862 11661177..00000011 3M_MNG2336490 3M MN02336490