Document Exoo2M5DR9L7jxgKXq94QKOwL

AR226-2744 E. I. du Pont de Nemours and Co. Haskell Laboratory for Toxicology and Industrial Medicine HASKELL LABORATORY REPORT NO. 55-61 K. '.,rial Tested: Ammonium Perfluorocaprylate Submitted by: 30 20 30 10 10 10 10 3 1, 1 0.1 2250 1500 1000 670 450 300 200 120 40 12 1.5 Liver (a. ) Poqy ta.) Body Ht ` X 100 1/1 Inactivity* red discharge around nose died within 18 hours 1/1 H l/l Discomfort, inactivity, initial wt. loss, died within 23 hours 1/1 Irritability, red discharge around nose, wt. loss, died within 43 hrs. 0/1 Ruffled fur, perineal discoloration, 28.2 452 wt. loss for 3 days 0/1 Ruffled fur, perineal discoloration, 25.2 474 wt. loss for 2 days 0/1 Height loss for 2 days 0/1 Inactivity, ruffled fur 0/1 Ht. loss for 2 days 0/1 None 0/1 None 30.6 16.2 24.1 25.2 24.1 342 374 530 598 592 6.2 5.3 5.6 4.3 4.5 4.2 4.1 Company Sanitized. Does nel contain t s c a c s i %# Comments: . -- Aononlun perfluoroceprylete ha* An Approxinat Oral Lethal Dota (ALD) of 670 ag/kg of body weight. Clinical signs of toxicity inciudedinactivity, a rad discharge around the noao, perineal discoloration and weight loss. Animals killed 14-15 days after having received doses down to and Including 800 ag/kg had enlarged livers when coapared to control rata weighing between -500-550 grama with liver velghta.of 22.6, 20.7, 19.1 and 21.7 grans and liver weight/body weight percentages of'4.2, 3.8, 3.6 and 3.8, respectively. Liver enlargement Is also suspicious In rats,dosed held* 200 ag/kg but additional teat-and control rats would have to be coapared in order to establish whether this Is a fact. Report by:_ I Approved bvt 73. 'i HS :hah November 8, 1961 Company Sanitized. Does net contain TSC CEi