Document ExJZDYapy9OnDx6VjpvQ2ebd0
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ARR8E _ 13]] UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
* rp
MEMORANDUM
APR 15 203
3 22
Rat] = 3558 5
SUBJECT: PPrFeOlAimi(nPareyrRfilsukoArsosoecsstmaAencnoitidoc)f the DgadiseveloSpajtsmental Toxicity Associatedwith
FROM: Kevin Y. Teichs 2Co
Director, Office of Scideq Polley (8 109R) ~ ew Thoma
TO:
Charles M. Auer
Director, Office of Pollution Prevention and Toxics (7401M)
rDevetlophemaenntdkaolcyuToomuxeifnoctrittiysheAwesolpslpoocorirtagutaneniditzwyeitdtoharnPedFviiOenAfwot(rhmPeaetrPifrvleeul.oirmoIionncaatrdadynioRtiiieosnkA,cAissdessnsdmeynotSoaftthee In
Sinofmoprrmeathieonns.ivOeuorvecrovmimeewontfstahree
issues and provided
a in
raenaasotntaabclhemernitsktaontahliyssmisembaotshreeaddnoodncauh.meenetxipsetiansg
es
a
Atachment
ce: KWialrleinaHmaFmamrelarnsdt,r$o1m0,18R601D JBaocbk HFeotwelse,,BB330055--0022
TAIN NO OB
1
ProinRnacytcedePapder
ORD CommeAnsstoscioantetdhewiPtrhelPiFmiOnAar(yPReirfslkuAosrosoecstsamneonitcoAfcitdh)e aDenvdeiltospSmaeltnstal Toxicity General Comments:
1 ttThhheegegeunosdeoenrfdtighfreefceharuleemnucalenasiainnngdmaeatrtaanbsgoeelriuosmfmdMaOtaEss fvoerryPFrOeaAs.ona"bTlhiesfiosretshpiepscrieallliymitrnuaernyecause of
eetrxrupmeorsapulirceteuxlrepeveolfs,theespienctieamllayl idnotsheissacnadsearnweldhaethreadelIotuhfetecroeilmnaettsihoeinnrsahrtia.tpsUbtsehetaownefweocnouirlnpdt.etrnlhaee]vxedltosesgmeiasvleas a
ilnimwihtiatcihonasaionnsgtuhereeodflaetMvaOelEasvaairlehaabnsloetbfetoehrnetsdheaevmaeeslsoienpsemsdam,letenhteaancsdonnfsoeitmdeaedrleinragths teTxhte,rbeutgrgeivmeannythe wanyd
nmuenaedyderebedesttboietmdtaeettrienargnmiiomrnaeolvtmhearoted.setlTishmeaftowirnatghethheusmearnu,mbluetvaelsgrienatFIdeoaflfaostfpiarodindnoigftiistohnreesos)ssaqan>uab.lew.oTuhlderbee
available
in
an
appropriate
y manner.
in
which
the
assessment
has
been
dea.
uses
the
data
2 CSTouhnmesmidadiresircieunssgsiitnohntehodefetgterxhtee.eaonAfidemdfiaftleicostntauildnliyes,soamtvheaeiplraobvliescioounlodfbaectsuiadledvablyuetshewousuelodfbetahbleelspfwuiltihn
SuSiudnaeysnowwnoeluiyglchdatsbseefsohreldpiffufle,reantidtoisedigffriocuuplst tiocnadsFee1st.emramFlioenrseeatxnoadmwpfhleaemt,aletxehtseefnatrctohumealsthepeuoeYrsoe,rakbf(of2ed0cyt0ea2dn)d
analyses account?
on
the
twwho-egreenetrhearteioins
ssttautidsytidcoalnesiugsniinfgiacannceestaerde
pdreosviigdnedt.akiWnegrleitrereinsttaotistical
3 uoTfshceeloadfroimtcoyurmienensstyonmptrehoeovsfiitdsheaesnadretcshuoolntrcsoluruegsphioordntiaesdrc.yussTstihoenodfocsutmudeyntrewsuolutls.d gHroewaetlvyerb,entehfeirtefirsoamltahcek atements and tables.
Specific comments
BPealggei|um-3p"lanptasr.agraph: Need to specify which serum PFOA values are specific to U.S. and
lePipamigidetee2mdi-oovElexoregaclyulstetivuvidedySeonufcmepmraoofrstayrn:ateeTffhceaecntaocueftrhPmoorFrsOtnaAloitteyaawnedaekmpaslsooycmiaetnitondiunpthae:firsWothcicluepatthieroenamlay be ewiexnapcklr.aenaasTtehdiiorsnisiiks aonfesetmdroeorneg tahsasonc3ia-tfioolnd,(wShMiRc=h3a.p3pef(aoerrsep1de0ctiyoaeplalrrysoomgfipevtmeanpdldfoiitnyidmoiennanglsta)frdgoomeisthneoMltoatartpeepresatrudtyo),bean
d to understand why the document characterizes he relationship as weak.
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4
iPnagthee3firsTthpearreagarpappeharasstcoobmepaanreidnctoontshiestleanstcyseinnttehneceroepforttheedthLiOrdApEarLagarnadphN, OAELfor FI males
Page 7 The value of the molecular weightof PFOA free acid ismissing.
page 8 for cach
In Table 1, compound
itnhethCe AtaSblneutmhbee"rF"foirn
t"hReFc"osmhpouoludndbeRr-eCm(o-0v)eF,
appears
to
be
incorrect.
Also
pPeargceent1a7g-e.Line 5: in reference to *>1-old," it would be helpful to Provide the actual increase as a
cePhahogloeesat1ne7rtolTn)hdaeinndegipsif.dseomImiteosolfdoitafyhfiesceuocltttih0oenrt(pe3al.r3aw)mheisatehriassrdbweteiongfomlolodwe,laendd(ip'rsesdiufmfaibcullyt ttroidgleytceerrmiidense atnhde
Cacdoadnaifmtoipuolnnedaleirbtsaiocdrkigfrrfiiosckuunlftdacttioonrfdsoeromfaitnitoenreosnithce.eapniadepmriioorlreiogihynycpslotutuddheieedssiieu.stendTet imwoafuoredasbasesehspesolmtpeefnnuttli.atloFohrave
ea(beogu.t biinotleorgaicetibonasbiest/wmeeecnhaPntFiesOrmmAifnoaerndewvhfaayltulaspetevicenilgfsis?ceSreinumdmiplotaririnlgtylsyfacorereraibldeeiolennvage)lssct).uodnisIesstehpeiredeamicoolnocgeircnally
ffect modification issue?
umption, is this an
t`Phwaehgee1n62b%9oo-tfhc3do*notspraeorlag)gr.roaupphTs:hperWaohsdsuyecseissdmn'estnitm5ipmloagir/nkitgnsc/ordueaatyseassisnigtnheedianscitdheencLeOoAfdEeLerin:st(e3ad0%ofvs5.03m8g%/,kgo/vdeary
TObfeh-tehsipsouewfrfteadcntdoicswcauunsrcrenerodttaiinntshienmceidi-ndboostehgtrhoeuhpigohf-Stamhnagdt/kl"goA/wd-stadayat:cisehtigocrwaoleulvpyses,rigtnthihifesiecbfaifnoetlcotigniocccraceluarssrieegindniaf1ti3cttahhnece
CtohnesLerOvAatEiLveiosrcoprmoptleicctasittvaeetdiaspbtpiycratolhaliycshsiinwgconoiunflsidicsabntteelntycoyduiifsnfeetr5heemntdga/ftkaig,o/mditacyco.onutlrFdoultsse.h"earWghuieldethhaet asemloercet:ion of
choosing 50 over 5 is needed.
r `explanation in
bBPieatcghaeut3so1em-tahiIennttlaihtietneYrasonwreekqrusetiuvadapylp,eanrdteindltilatynerynozotefr,tahenldinotemeoinsazhteoadullamnodrtraeldiitSyuioocgctuergw(iwtihtihnintheeascahmdeosleittgerro?up) at
tthaekepnositn-towecaonnisindgelroastsieosn?when
analysis
was
d conducted
be to
used a0. lustre
tshtegsutgatiirs]ticuanlit.sigWniafsictahnicse
of
oiPnsadgeiecal3te5eved-ltI(hnTaotaxtirhceeoclebnoitgpihpsartseis7ce2n:et1la4it8mi)io.nnatTatihoitnsheomfSaoPycFieOtAy oifn Tthoexifceomlaolgeyrmteedteipnegn,dsKeomnptehte a(naddmiJneipsstoenred) bl(ooLsede.y,tbphu-er3dh5ie)gn,haecesnitdlianldgim)miitnsisttheerpeodsdsiobslees eyfifeelcdtesdofatachsceeoru"unhmtilfgoehrv"etlaohdefmaiPpnpiFasOrteeArrsesdspadtoeunr.ea.t1i(odntuhKeaitntewotiaitnchsaapreplpaoorwreetnretd
. The assessment should address this point
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Page 39 Line 16: What docs the denominator (28) of the ratios denote? NbFeOaAtehEedLs6,ta-nLIdnOarsAdeEcftLoiroontrh5eB.0pM,oDiinLntt,hoefnod1te*pBpaMarrtDau,grrea0pht,hethheuMmOanEesxhpoousludrebeledveefl.ined1as tBhMe rDatLiohoafs tchoeme to tsPhuaoggsgeees4itn6edt-,hAetlshteehrorueumpgoh(ritanecdmcouensmtkuielmayatsti,ioonpn.so1fo1f,PtFahnOedAcihnienmitchalliivnerthtehrloiuvegrhweenrteersouhreppraitsiicngcliyrcluolwateironthwaans aPpFpaOrAenwtedriescdreetpeactnecdy iwnarsrearnutms,f9u0rt%hoerfctohmmelinvter,rai,lepv.el1s2).irIen fbacet,lindheumraensn, (w5h.i4l6e).loTwhliesvels of hPPoaFrgOmeoAn5a4(ul-sliTynh-gdeiFavOsesfneescmslamelaeernatvnaaclseutemuste)eclihynaptnohiiensrtmast(opn.euo5tn4h)a.tepsotdeuneti1a0l tuhnedefriemstriemqautiiroenodffotrhmeatbuordaytibounrodfenthoef aSrgaeengssmpaeonrndttetrihsseis(riOmmAaptTlu)yriatthiecoirnteeldataisveelvyidleonwcel.eveAlnsofadtdhietiToshneaexldhpeoivreemcleoonopefmsieinnnftocsrimepruaolifaoitnlieoonnubyoolresgatraelnryitcphoeasinrtinoantal
al increase in the frst 3-4 weeks ofpostnatal fe ofr rat pups. OoPffafgPsepFri5On5Ag.-wSiTethchtaitcoosnn,t5ti.5hn,uier9deexpxpaporosasguurrarepeph1r,0iolFra1sttom2waseleeansntiecnnocguelsmd:igalhItstowboceuolnd tsereem tlsikgerleygtrheaatttehreeaffceccutmiunlation ae2b8xoptuohtseeytdhdeteoivmepplrooeprneattdaa,nlctlehyoeafynwddoeevuaelrlldoypbpmeogesintntnattoalalcyc.umWuelaatesssuemreumthilsovsieislmswihloaavrtetr1oatmngheoacfpbthyetwFhheOatcfoetmmhaemlyeenswe,treb,ut
al exposures, but it could be fun.clarified. Panadgesu5b5st-itSuetcet"iiocn.5".5, 11" paragraph, 1 sentence: rik the first "whether (i's there twice)
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