Document ExBZ1MV6Lww11VN5yoDyBQ9dV
AR226-2866
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E. I. du Pont de Nemours and Company Haskell Laboratory for Toxicrlogy and Industrial Medicine
HASKELL LABORATORY REPORT NO. 984-77
Material Tested
Haskell No.
11,336
Sample Ready for Testing
9/20/7
Other Codes
________ Material Submitted by Organic Chemicals Department, Jackson Laboratory
ORAL LD50 TEST
Procedure; The test material, as received, was administered by iutragastric intubation to six groups of ten young adult ChR-CD male rats in single doses. Survivors were sacrificed 14 days later. The LD50 value was calculated from the mortality data using the method of D. J. Finney.t
Results:
Dose (mg/kg)
Average Body Weight (g)
Solution (%)
A~ cage Dose (ml)
Mortality Ratio
Clinical Signs
LD50***
32,530**
247
As Received
7.43
10/10
Prostration, weakness, belly-to-cage posture, labored breathing, and lacrimation at 32,530 mg/kg.
13,792 mg/kg
20,000
241
As Received
4.46
10/10
Prostration, weakness, belly-to-cage posture, labored breathing, lacrimation, chromodacryorrhea, eyes half-closed, wet and stained perineal area and weight loss at 20,000 mg/kg.
18,350
244
15,000
249
As Received
4.14
As Received
3.45
8/10 6/10
Belly-to-cage posture, prostration, labored breathing, salivation, weakness, chromodacryorrhea, diarrha, lacrimation, alopecia on neck, opaque spot and exoph thalmic left eye in one rat, wet and stained perineal area, stained nose, mouth, and body, and weight loss at 18,350 mg/kg.
Prostration, weakness, belly-to-cage posture, chromodacryorrhea, wet and stained perineal area, stained mouth and nose, and weight loss at 15,000 mg/kg.
- 2-
Results:
Dose (mg/kg)
12,500
(continued)
Average Body Weight (c)
244
Solution (%)
Average Dose (ml)
As Received 2.82
Mortality Ratio
4/10
11,357
238
As Received 2.50
2/10
t Finney, D. J., Probit Analysis. 2nd Ed., 1952, Cambridge University Press.
** Administered as a divided dose.
*** 95% Confidence Limits:
Lower
Upper
12,091 mg/kg 15,289 mg/kg
Slope 9.38
CMH:scg Report No. 984-77
1977
Clinical Signs
Prostration, belly-to-cage posture, labored breathing, weakness, chromoda-- cryorrhea, lacrimacion, convulsions; piloerection, exophthalmos, and weight loss at 12,500 mg/kg.
LD50*** 13,792 mg/kg
Belly-to-cage posture, prostration, weakness, chromodacryorrhea, piloerection, wet and stained perineal area, stained mouth, nose, body, and around eyes, and weight loss at 11,357 mg/kg.
orally to young adult ChR-CD male rats; its LD50 is 13,792
Report by:
QapoUytj %.
Carolyn M. Hall
Toxicologic:
Approved by:
0.
A. Michael Kaplan Chief, Oral Toxicology Section
srwmpany Sanitised. Does not contain TSCA Cl
