Document Ex5BbM6wR7m085dZbmBbonw3j

POTENTIAL HEALTH EFFECTS AH!) MEDICAL INFORMATION HEALTH * ENVIRONMENTAL SCIENCES T.I.M.E. SYSTEM DR-0002-5310 HE X AC HL OROBEN 2 ENE THIS INFORMATION APPLIES TO THE STATED MATERIAL AND MAY NOT APPLY TO DILUTIONS OR FORMULATIONS OF THE MATERIAL- SYNONYMS: BENZENE, HEXACHLDROPERCHLOROBEN ZENE HCB CAS NUMBER? 0000119-74-1 APPEARANCE? WHITE NEEDLES FACE 1 07/03/69 REPT A EXPOSURE GUIDELINES HEXACHLOROBENZENE: DOW BIOLOGICAL LIMIT GUIDE IS 150 PPB IN THE BLOOD, THERE IS NO GUIDELINE FOR AIRBORNE CONCENTRATIONS. ----------------------------------------- POTENTIAL HEALTH EFFECTS --------------------------- REVISED: 04/29/88 THIS SECTION INCLUDES POSSIBLE ADVERSE EFFECTS WHICH COULD OCCUR IF THIS MATERIAL IS NOT HANDLED IN THE RECOMMENDED MANNER. EYE - ESSENTIALLY NONIRRITATING TO EYES. SKIN - ESSENTIALLY NONIRRITATING TO SKIN. ** - A SINGLE PROLONGED EXPOSURE IS NOT LIKELY TO RESULT IN THE MATERIAL BEING ABSORBED THROUGH SKIN IN HARMFUL AMOUNTS. - THE LD50 FOR SKIN ABSORPTION IN RABBITS IS >2000 MG/KG. - REPEATED SKIN CONTACT PRESENTS A HAZARD DUE TO ACCUMULATION OF HCB IN THE BODY. ~itNGESTIGN - SINGLE DOSE ORAL TOXICITY IS LOW. - THE ORAL LD50 FOR RATS IQ 3500 MG/KG. - ALTHOUGH SINGLE-DOSE ORAL TOXICITY IS LOW, INGESTION OF SMALL AMOUNTS PRESENTS A HAZARD DUE TO ACCUMULATION OF HCB IN THE BODY. ACUTE INHALATION EFFECTS - VAPORS ARE UNLIKELY DUE TO PHYSICAL PROPERTIES. - EXPOSURE TO DUSTS MAY CONTRIBUTE TO THE ACCUMULATION OF HCB IN THE BODY. SUBCHRONIC EFFECTS - EXCESSIVE EXPOSURE MAY CAUSE NEUROLOGIC SIGNS AND SYMPTOMS. - REPEATED EXCESSIVE EXPOSURES MAY CAUSE ALTERED BLOOD/BILE PIGMENT METABOLISM (PORPHYRIA) AND LIVER, KIDNEY, SKIN, NERVOUS, SKELETAL, MUSCULAR AND IMMUNE SYSTEM EFFECTS. O * TRADEMARK OF THE DOW CHEMICAL COMPANY RESTRICTED - DOW USE ONLY DO 0 7 3 6 8 9 J> POTENTIAL HEALTH EFFECTS AND MEDICAL INFORMATION HEALTH & ENVIRONMENTAL SCIENCES T.I.M.E. SYSTEM DR-0002-5310 HEXACHLOROBENZENE PAGE 07/03/89 REPT A CHRONIC EFFECTS / CARCINOGENICITY - HAS BEEN SHOWN TO CAUSE CANCER IN LABORATORY ANIMALS. - FOR HAZARD COMMUNICATION PURPOSES UNDER OSHA STANDARD 29 CFR 1910.1200, THIS CHEMICAL IS LISTED AS A POTENTIAL CARCINOGEN I ARC. PART BY NTP AND TERATOGENIC EFFECTS, - HAS CAUSED BIRTH DEFECTS IN LABORATORY ANIMALS ONLY AT DOSES TOXIC TO THE MOTHER. - HAS BEEN TOXIC TO THE FETUS IN LABORATORY ANIMALS AT DOSES NONTOXIC TO THE MOTHER. - TOXICITY TO THE NEONATE BUT NOT BIRTH DEFECTS HAVE OCCURRED IN OFFSPRING OF HUMANS KNOWN TO HAVE INGESTED TOXIC AMOUNTS OF HEXACHLOROBENZENE. REPRODUCTIVE EFFECTS - IN ANIMAL STUDIES, HAS BEEN SHOWN TO INTERFERE WITH REPRODUCTION . - HOB IS BIOCONCENTRATED IN BODY FAT AND IS TRANSFERRED TO THE FETUS PLACENTA AND TO THE NEONATE VIA LACTATION. VIA THE MUTAGENICITY - RESULTS OF IN VITRO {'TEST TUBE'> MUTAGENICITY TESTS HAVE BEEN NEGATIVE. - RESULTS OF MUTAGENICITY TESTS IN ANIMALS HAVE BEEN NEGATIVE, EMERGENCY TREATMENT AND MEDICAL NOTES ----------------- REVISED:02/24/88 EYE - IRRIGATE IMMEDIATELY WITH WATER FOR AT LEAST 5 MINUTES. SKIN - WASH OFF IN FLOWING WATER OR SHOWER. INGESTION - INDUCE VOMITING IF LARGE AMOUNTS ARE INGESTED. CONSULT MEDICAL PERSONNEL. INHALATION - REMOVE TO FRESH AIR IF EFFECTS OCCUR. CONSULT A PHYSICIAN. NOTES TO PHYSICIAN - INDIVIDUALS WITH CHRONIC OR LONG TIME EXPOSURE TO HEXACHLOROBENZENE SHOULD RECEIVE BIOLOGICAL MONITORING OF BLOOD LEVELS. - NO SPECIFIC ANTIDOTE. ~ SUPPORTIVE CARE. TREATMENT BASED ON JUDGMENT OF THE PHYSICIAN IN RESPONSE TO REACTIONS OF THE PATIENT. - REPEATED EXCESSIVE EXPOSURE MAY AGGRAVATE PREEXISTING LIVER AND KIDNEY DISEASE. * TRADEMARK OF THE DOW CHEMICAL COMPANY RESTRICTED DOW USE ONLY DO 0 7 3 6 9 0 C O N F ID F N T T I> POTENTIAL HEALTH EFFECTS AND MEDICAL INFORMATION HEALTH ** ENVIRONMENTAL SCIENCES T.I.M.E. SYSTEM DR-0002-5310 HEXACHLOROBENZENE PAGE 07/03/89 REPT A END OF REPORT; FOR ADDITIONAL INFORMATION CONTACT: CHEMICAL HAZARD EVALUATION & COMMUNICATION HEALTH * ENVIRONMENTAL SCIENCES 1603 BUILDING, MIDLAND, MI 4Q674 PHONE <517) 636-1909 oO a * TRADEMARK OF THE DOW CHEMICAL COMPANY RESTRICTED DOW USE ONLY f6