Document Ex0vwN6m16XBvqOq1JbJKyYb0

^WOtMv, IV S Ey UNITED STATES ENVIRONM ENTAL PROTECTION AGc WASHINGTON. D.C. 20460 /V L/rX/rZLt/^~) OFFICE OF RESEARCH ANO DEVELOPMENT 18 D ecem b er 1987 MEMORANDUM SUBJECT: R eview o f "A C a n c e r R is k 2, 3 ,7 ,8-TCD D ". ic Dose E stim ate For FROM: G. L. Kimmel, PhD D evelopm ental Toxicologis THRU: W. H. F a r la n d , PhD Ax A c tin g D ire c to r, REAG JeL L TO: P. W. P r e u s s , PhD / D irecto r, ORSSA * I have exam ined th e docum ent, esp ecially as it re la te s to the inclusion of inform ation on rep ro d u ctio n and developm ent. believe the section on rep ro d u ctio n and developm ent fits much b e tte r th an it has in p rev io u s d ra fts. I One c o r r e c tio n t h a t s h o u ld be m ade r e g a r d s th e RfD. T he RfD t h a t w as d e v e lo p e d in my is s u e p a p e r w as 1 x 10"5 u g / k g / d a y . T h is t r a n s l a t e s in to 10 p g / k g / d a y , n o t 1 p g / k g / d a y .