Document EvMgkZ5E2JkR9n2a5QYJRNvjx
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runajLib'.'ity-iB-t-UN
10:3.9
03U3 fS9 .1825
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FAX
bale: Fshruaryn, 1997
TO: MatK.ocnmg3 DuPottt
- Fiwx^-yeo'-yzw
POLl'lIBtS
AR226-2149
Number of pas** S'idu^i caver .ihfft 2 | FROM: W. A. 'Wtppaer
3MA&CM Group 223^S-04 St.Paul.MN 55144
J'Acat; FAX Phone: (302)999-4925
Phons: (617.) 733-6374 FAXPhonv (613.) 736-7542
MESSAGE: Mall K.oeoinfft: Attached arft 3Ms qucttions on env;TOnmcntal issues for our proposed meeting.
W- A. Wcppner
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0302 BBS (B2S
POLMBRS
12603
NU.U/1 i-^
BNVDLWMENTAL QUESTIONS:
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PorthBpuipoaeofdeflninsibiamottrcprtStsnUtivesan^ilesforanalysiabySM.howinBiiy
sites are involved and hva llifly b<wi characterized geologically and hydrotopcally?What is the depthto groundwater, d^tii 10 unpcnneahialayer, gioundwotr flow rale sosi direction,
ett.
Are thBaHMtiaiilar in regard to tlnirchaiacteriftics (type of oil) or rft the soils very
tliffcieol?
-",i,^~ ^.S "Whiti aalyxR of soU and grouodwatcr have bcea don mid what are <he results? HBVB &
.
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3. inrnpleaIwntheantoatley]zeodrgfaonritcoftlattloorrignaenciocnfclutionrtirnaed?onH?oWwhilaotcotAher cfloaaocrciaB&trtaetdiocnsoysfwPaCs-1in43
concioucatiofls?
'
'Io'r
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"t^ compare lo
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FC-143
ue
known
orbdl>ved
to
be
present
and
al
what
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IUf3JMllwWwICBlloU^p6e1r.fLoUnlaLLaan"a.lny*t.u/,^c-f.f,,li--o.--la--m--plre--s,--li.o- wBmay
anqle$of each type
amplea?
(8011,water)
mil thaire be? 'What u the expected lower conewR--tr--a^t--io--n tlitm^.ilt-.itn- Adite. .aw^l^<>
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02/2B/87 U:i7 nm 008 4938
POLYMERS
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TOXICOLOGY QUESTIONS:
1. What does DuPont. hope to gain from the sub-chronic monkey capsulctceding study with t'C143 (APFO)Btven that:
a) Aero was an 11% (8/76) incidence of pancreaticadenotna/earemonu in ran fed wo years
at 300 ppm; thenfore, 4ns effect would not be expected to occur in a 13-week monkty study and would requite 80 monkeysper dose in this dose range to observe the effect lu &
lifc-tiniB studyin mookeyi: b) a. 13-wodc itudy in monkeys is noi lilmly 10 produce observable pancreatic effects nc
pancreatic effects in rat are obsKved only after TWO months of feeding with lha Wywth
compuusul, A mw;li sLrongcc ptroxisomfl prolIfcrBtor thnn APFO;
c) the mechamsni by which DuPont foeli APFO/CCK may be reluled to production of pancreatic tunion u nut fully undcrttood and, iherefbie^ how will a sub-chronic monkey Study help to elucidate that mcchimam without additional background research'/
2. What us^ Ufuw is PuPoia conceined about ith iMpect to APFO and how are theie retlectcd in the endpomts and hypotheses DuPont wishes to vcsA la a sub-chronic study in moiAtiyai?
3. Relative to ihe multiple effectors on honooiuu levels, dou DuPont feel comtbnabic with the validity ofusinc {wnnoau levels generated in B tub-chronic monkey Study to adequately ussess ft health, cftbct endpobu?
STEWARDSHIP QUESTIONS:
1. "What u life cycle cxposuie analysis of APFO after it is received by DuPont?
2. 'What are workplace controls throughout nianufaciure and fonuuloiioii?
3. What are disposal and recycling methodi used to raduc onuiroumentat exposures'/
4. Ho'*' daca DuPoot conuol iu fbnnulttort?
5. Wluu arc the consumer conecnu with rTFE? And how docs it relate? s
ts>
6. 'WhB.t were PDA's concenBwitiiPTFE't food additive iqip1'011100^
41.
7. Could msidualAPFO (when heated) eoinio food and Ixniaiwa?
8. Wht Bbour other PTFE applications, i.e.: tape? Will APFO be released?
9. We would like w. ciq)ouw aiuyaii ({.. concerns) tplit out for APFO oy physical form? (PC-143 vi.FC-118)
10. Dot PuPont supply explicit instructions for fonnulaton on handling and disposal?
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