Document Ev8D9bv9Y7or3MoeoQRR5QOgx

Giyj | VIKER LLAABBOORRAATTOORRIEIESS.. IINNEC.. JJIuJl[. 114411998800 Interoffice Correspondence Inter0ifice Correspondence: cei cc: JSJ.lMWo... LBBeaelzleiirsstlleee FJRLR..UADAA... ULNNbaeeZlleassroo:nnt//eTT..LL.. KKeerrlleeyy To: R.A. Prokop TO: R.A. Prokop FROM: RE. Ober FROM: R.E. Ober suly 10, 1980 July lO, 1980 aJJaolnnreaB Bdeeylliisscllleeearbberrdoouugmghahtntusbbcyyriffopotrr mmoyny cScoeomrmumeanetnOtsrsgaoonnnicTT/uueeIssnddoaaryygaonoiffctthFhilissuowwreieenekek aaLevccoeolppsyy ooofff tthhee RaRpuolurrieranaaltldsyCCh-hicinmnleeoeasssertee,l.dy mMm Moyyarneoouvvessercpraeralicplliltfiotthcnhoouu-Sggeharhutrtmsse waaOnnrrddigtatccnoeomnimcme/oInennntotssrtgheaaarrnecaictotouaFutcltluhliienond~reinddceopbbyeLelelooovwwfe;;lsthaaeodddfdiittiioonnaall mpaoniunstcsri-ptm.ostly more specific - are written on the attached copy of the manuscript. muu|I ynnaaiiqgqgiururmeeeepeeraaennttshddhsaaitnomtnaakttkhebeheeeyaaonnddnaadttiianantttehfferrarroetoemnssttiiiCsCnnhhggitinnhaaacctooaannartrtenerriibwbuwuounortntritietohhocnnesppsuttuoaobbrlliyttishshhhaiisinsinndggrr.e.epssoeetTaaTehhrnrceectyhyhialaaaalrrrreeeyeaa.cnn. ooovuvenHHeltool,ew,wreevppveprreroror,bob, adabublc]yytive maeemfyfoffouoim nrrtttpsreiisossfsmmioasandedereubmettoyooonrrredgeaaacncthhihcaaatnnflisuiinonrtttehiernarieim tmaincncoohnunucncrlnlauuensscsiieo.osnnsaAaarsybboouaJutnotdn tthghpeoeoetssseoonuturotriccaeeslolymoofefcotlthheueenngtttterhrara-cpcteeoroductive aaiinmllalloluuuyssnttttirrscaaattoleef,, usenttrchhueeemrtaaavoviaarngiitllaiaanebbiscll.ee fldduaa|ottaarsiunaagerrgeeesintddiiffhtffhuiiamtccauunlltstth. ettoAolsoniigJnnattneerrrappgnrrgoeeeetts,,itnopptrresiirommemsaaterrsiillleyyonfgbbebethocctoahuutosseethoeoff a5iinnnaaddlniiydvvtiiivddciuuaeaalwllsisnugniicnnetvvrhootlelavveiepddnatpieaaernnsdd.as33 HaI wwoousuusullegddfguelsbb,tee btbiehenatttttteeerrretshtessieenrrlgvvoeenddgandbbryyannoddgveeeellleeittniistnnceggireemmsnoottsssittfiocfooffcbopopptpn..htr4i4tbhueaatnnddion q5tuooeansiidtnniffovoonirremmwoaafittniigooinnntduhiisenntrtptihhaaiiplsseraasrraoeesusar;;caesbbuuusttoeffuddloos,nne''rttuinnaatottetrtregeemmasppntttiicngttooFalnuuudossereinnottevhh.eeel ppAaassppceeirre| nhdtdeaiefvffeieencnssmiiecvvnoeetnllityyornieoobdnnutittohhnee Vooqnnusecsnnituuimmeoeennrrtooiuuoicssffppiqaansusdtteussttooriccioccanaalsssssiis|oooinnuksser,,ce"swI| haotttfhhiinnsikkesrmumtamahiiennottrsaagoiiaunnnriicinnecggoffcclrrueoeodrdrigiibnabieinl.liiicttyy,AfsluppoaaI rrritthniiaeccvuuelliaamnrrellnhyytuimoaoonnnned ma"assrarseeeiecrraaniuutemman,,ooi"t"ffnifssssihuchucoobrb"uuttelllldddeeiqbuiepbbpleseooitttteieaaynnottnppiisrrIaaiisllnmlaatirroeekyyeffffnegeo"goccotwaatthllssamtakooooeffffis u33iiMntnnnhddaeeauussscsttesrwrwsoieiesuaaarllrcccyoeonncctthaohifenienmdnmuiiuoeccertaagellaciissnhnn..inttcioocaOOtftlnnhhlleieiuyssowwrauairrynynaaecppeiittrddooitllnayyhhieehnleleupxpmxadppnaeannfddeiinnnsggive emfafionrttasi.n credibility is to not make unnecessary and technically uncertain defensive efforts. Thanks for the opportunity to comment. | hope my input has been helpful. Thanks for the opportunity to comment. I hope my input has been helpful. REO:nho REO:mho Attachment Attachment (a? PS: PS: gSSoiiannlcceeoftthhiitsshimmseemnpooapwewarasswattysyppeetddo,, re|I fuhhtaaevveethlleeeaarrsnnteeaddtemffreronomtm yy(oopuuroaabnnaddblyJJoaonnvetthrhsaatttataaemsseppnetec)cififioiccf wgGGhuouiyyaclhaanonddhfe TTthcaalvvisaeesisnpsrraeepggteoaarrrddhwiaiannvsgge toftthoheuernedssfuppetieecncifittfhihicece ssiidetdareetunenmtmtiiotteyfyntootfhf(epssrogoomembneeaebroolafyfl otthhpveeoeprusfflltluaauottoeriromoocnceh.hneetm )nWiicoicaafllless ownhichyetheancolatihmers troeadhianvge ofofuntdhe inpaptheer s| ecruomuldofdethteectgetnheeram] espsoapguelarteionGu.y andWhile on yet another reading of the paper I could detect the message re Guy and 11223344..00000011 Exhibit 1234 commen soviems| SMAto03407 3MA10034975 ae -2- ~Tccraaooevvggleeeeessnan,,sttell)yy1I''tmmtthooaaatmmffeerr..waaiioddulIIdsstthhmaattatthhkeeemrrmeeeesspssaaoannaigyygneteoodtmtdhiohierdderernnwcwooalattyyeaaarnonoldrdrydaadaonnoyneyesdsmmoodnnrriooeertteccccctoaoolgmgmyeeee?nntttthhdArdras~attaavv| eemrr((yeyaanpptccppillrroeeoonaapperrrrdlliiyyaatoteaneannddftfohorer vpprohhenoolnn'eeeat,,s'eb)ecCoouuttnnohtotaeterrhiiwennolggpufludGGluuyym''aisksneootvvhpeeeorrissnltttoaanttgmeeonmrreeeunnnttclwweiiattrhhlyaannandoovveedrrissrtteaactttleeymm?eennttAsooff I oouumrrentooiwwonnneppdrroobobnaabblltyyhe won't be too helpful in the Iong run. 11223344..00000022 33MMAAT100002344997766 `SERUM ORGANLC/INORGANIC FLUORINE LEVELS OF RURAL CHINESE Jon Belisle 33H CCoommppaannyy,, 33MM CCeenntteerr,, CCeennttrraall RReesseeaarrcchh LLaabbsorraattoorrJi[eess,, SStt.. PPaauull,, MMNi 5555113333 WWIIYTEH TTIHIEE OOBBSSEERRVVAATTIIOONN1! TTHHAATT TTHHEERREE AARREE TTWWOO FFOORRMMSS OOFF FFLLUUOORRII~NEE I[HN HhUOMMAANN SSEEER/U/MM ((EEXXCCHHAANNGGEEAABBLLEE A~XD NNOONN--EEXXCCHHAANNGGEEAABLLEE TTOOWWAARRDDSS 11885F-)),, RREESSEEAARRCCHH2? AHASS BBEEEENN DDIIRREECCTTEEDD AATT IIDDEENNTTIIFFYYIINNGG TTHHEE NNOONN--IIOONNIICC ((AALLSSOO KREEFFEERREREEDD TTOO AASS TTHHEE NNOONN-EEXXCCHHAANNGGEEAABBLLEE,, BBOOUUNNDD,, OORR OORRGGAANNIICC)) FFOORRMM.. FFUURRTTHHEERR SSTTUUDDIIEEZS IINNDDIICCAATTEEDD TTHHEE WWIIDDEESSPPRREEAADD PPRREESSEENNCCEE IINN HHUUMA~N PPLLAASSMKAA3D OOFF OORRGGAANNIICC FFLLUUOORRII~NEE WWIIiICCHH WWAASS NNOOTT DDEETTEECCTTAABBLLEE IINN TTHHEE SSEERRUUMM OOFF AANNLIMMAALLSS4 TTHHOOUUGGHH OOTTHHEERR SSTTUUDDIIEESS RREEPPOORRTT TTHHEE FFIINNDDIINNGG OOFF OOKRGGAANNIICC FFLLUUOORRIINNEE IINN BBOOVVIINHEES5 AANNDD KRAATTO6 SSEERRUUMM.. SSIINNCCEE TTHHEE WWIIDDEE-S`SPPRREEAADD OOCCCCUURREREEIN~CCEE IINN HHUUMA~N BBLLOOOODD OOFF TTRRAACCEE AAMMOOLUINNTTSS OOFF OOFRGGAANNIICC FFLLUUOORROO-CCOOMM?POOUUNNDDSS DDEERRIIVVEEDD FFRROOMM CCOOIM~M4EERRCCIIAALL SSOOUURRCCEESS HHAASS BBEEEENN SSUUGGGGEESSTTEEDD2,? WWEE DDEECCIIDDEEDD TTOO OOBBTTAAIINN BBLLOOOODD SSEERKUUMM FFRROOMW HHUIM~ANSS LLIINVIINNGG ITNN AA NNOONN--IINNDDUUSSTTRRIIAALLIIZZEEDD AAR/E~A:; OOUURR AAIN~AYLSY]S[TSS IINNDDIICCAATTEESS DDEETTEECCTTAABBLLEE OORRGGAANNIICC FFLLUUOORRIIIN~EE IINN TTHHEESSEE PPEEOOPPLLEE 2S VELL. [cTohnecjlouusrionnalto(NtAhTeUREr)eseraerqcuhi,reschotrhoafofriersinpacraapgitraalphlectocebres.a) brief background and 11223344..00000033 33MMAA1100003344997777 2 Several methods of analysis have been used for total fluorine in Several methods of analysis have been used for total fluorvne in sseerruumn//ppllaassmaaa,. HMoosstt ssaamzpplleess hhaavvee bbeeeenn aannaallyyzzeedd by by open open ashing ashlng Vhich which 1s is lkannoowwnn ttoo ggiivvee aa vvaarriiaabbllee lloossss ooff fflluuoorriinnee5'.. FFoorr eexxaammppllee,, oonnllyy 2211%% ooff aavvaaiillaabbllee fflluuoorrii~nee ffrrooam ppeerrfflluuoorrooooccttaannooilce acid acid 1s is recovered reco%ered as as inorganic inorganic fFlluuoorriiddee ((ssaammppllee ssiizzee nnoott ssppeecciiffiieedd))2?. TThnee uussee ooff tthhee cclloosseedd ooxxyyggeenn bomb eechniqueS+6:7 avoids sos of these losses and ow furcher work bomb echnique5,6,7 avoids most of these losses and ou* urther work iinnddiiccaatteess 9900*+%% rreeccoovveerryy ffoorr ppeerrfflluuoorrcoooccttaannooticc aacciidd ((i1--55 uusg))7!. Wich the kind cooperation of the edical authorities fron the WiKh Khe kind cooperation of the medical authorities from the People's Republic of China, eight husan serum sasples vere obtained People's Republic of China, eight human serum samples %ere ohtaned frroomm CChhiinneessee ddoonnoorrss wwhhoo l1iAvvee fgnn aa rruurraall ccoo~muunnee wwiitthh lli~ttttllee cchhaannccee ffoorr exposure to industrial fluorochenicals. The sasples vere analyzed for exposure to industrial fluorochemicals. The samples w~re ana]yxed for Fluorine by the oxygen bomb method? which 1s known to te more reliable fluorine by he oxygen bomb method7 which is known ~o ~e more reliable cKhhaann tthhee ootthheerr maestthhooddss iinnvvoollvviinngg aasshhiinngg5'.. TTaabbllee 11 OOrrggaannticc//ITnnoorcggaamniicc fflluuoorriinnee lleevveellss ooff rruurraall CChhiinneessee rerson Person 11 22 3 3 4 ` s ~ . 6 77 8 8 Orpanic Fluorine Organic Fluorine 00,.000088 ppppmm 00..001133 00,.0011 00..00114 0.009 o. 009 0.0,000099 00..0000~4 00..0017 Inorganic Fluoride Inorganic Fluoride 00..005311 ppppmm 00.,005564 00..00466 00..004466 0.01 o. o44 00..008499 00..004666 00..007766 11223344..00000044 33MMAA1100003344997788 3 ALL All the the samples sampies (Table (Table 1) 1) had h~d detectable detectable organic organic fl:uuoorriinnee levels. levels. A brief review of the literature indicates that the determination of A brief review of the literature indicates that the det,~rminat~on of organic fluorine (ashing) in 65 plasma samples of persons residing in the organc fluorine (ashlng) in 65 plasma samples of perso~s residing in the state of New York gave an average value of 0.03 ppm organic fluorine state of New York gave an average value of 0.C3 ppm organic fluorine wwiitthh tthhee lloovweesstt vvaalluuee aatt tthhee 00..000055 ppppmm lleevveell3.. IInn aa ilaa~v:eerr ssttuuddyy iinn-- vvoollvviinngg 110066 iinnddiivviidduuaallss lliivviinngg in in five five different different cities cities in ~n two two different different ssttaatteess,, aa mmeeaann ppllaassmaas oorrggaanniicc fflluuoorriinnee vvaallvuee ooff 00..002255 pppam ((aasshhiinngg)) wwaass oobbsseerrvveedd wwiitthh 22 ppeeooppllee ees~ttiimmaatteedd aatt lleessss tt~haann 00..000055 pppaml2.. IInn aa recent study of 264 people living in one Minnesota community, an average recen~ study of 264 people living in o~e Minnesota =omm~nity, an average oorrggaanniicc fflluuoorriinnee vvaalluuee ooff 0.045 0.045 ppm ppm (ashing) (ashlng> was was reporcid report~d wich with che the Lowest person having non-detectable organic fluorine (000 pp). In lowest person having non-detectable organi~ fluorine (0 00 ppm)8. In a current report from Argentina, analysis of a pooled suru sample in a curren~ report from Arg~ntin~ on~]y~s of a pooled s~rum sample in- dicates an organic fluorine level (ashing) of 0.085 ppa'. Analysis of dicates an organic fluorine level (ashing) of 0.085 ppm-. Analysis of 9 individuals (timmesota residents) gave an average or 1.02 ppm organic 9 individuals (Minnesota residents) gave an average or {~.02 ppm organic luorine (oxygen boab) with the lovest person a 0.01 pia'. fluorine (oxygen bomb) with ~he lowest person at 0.01 ppmT. Fron Table 1 and the sbove cited literature, the organic fluorine From Table 1 and the above cited literature, the organic fluorine lLeevveellss ooff tthhiiss rruurraall CChhiinneessee gg~roouupp are are at at the the low low end esd of o:~ the the range range when when compared to a group representing a more urban environment. compare~ ~o a group representing a more urban environme~t. The The iinnoorrggaanniicc fflluuoorriiddee lleevveellss wveerree sslliigghhttllyy hhiigghheerr tthhaann tthhee lleevveellss iinn tthhee ccaassee ooff oouurr pprreevviioouuss ((00..0022 ppppm)) MMiinnnneessoottaa ggrroouupp'7 aalltthhoouugghh iinn aannootthheerr wwoorrkk8S,, aann aavveerraaggee vvaalluuee ooff 00..005588 ppppmm wwaass rreeppoorrtteedd.. GGuuyy)3 rreeppoorrtteedd a mean of 0.015 ppm inorganic fluoride and later showed che plasma a mean o O.DI5 ppm i~organic fluoride and later showed the plasma inorganic fluoride level to be dependent on the level o FTM in the inorganic fluoride level to be dependent on the level of! F- in the ddrriinnkkiinngg wvaatteerr.. Therefore, the slightly higher Chinese inorganic F~ Therefore, ~he slightly higher Chinese inorganic F- Lleevveellss mmaayy bbee dduuee ttoo tthhee Fflluuoorriiddee iinn ddiieett and and drinking drinking vater. ~ater. 11223344..00000055 33MMAA1100003344997799 4 AAss tthhee ccoonnjjeeccttuurree ttoo tthhee ssoouurrccee aanndd iiddeennttiittyy of tt~iee oorrggaanniicc fflluuoorriinnee of in blood continues, it would seem helpful to compare ashing and bomb in ~lood continues, it would seem helpful to compare a~hing and bomb rreessuullttss.. WWhhiillee aa fflluuoorroocchheesmiiccaall hhaass bbeeeenn iissoollaatteedd firroons ppllaassmmaa2? aanndd suggested to be perfluorooctanolc acid, that compound ls recovered by suggested to be perfluoroocCanoic acids that compound is recovered by the sase researcher only to the extent of 20 % (ashing), vet the bomb the same researcher only to the extent of 20 % (ashing), yet the bomb ((9900+% 7% rreeccoovveerryy7)) aanndd aasshhiinngg rreessuullttss ooff sseerruunm//ppllaassmmaa aa~cee qquuiittee ccoommppaarraabbllee;; ffoorr eexxaammppllee,, 00..002266 *~ 00..001166 ppppmm SSDD ((nn == i10066~, aasshhlinngg))2? tt)> 00..002222 % 00..000077 SSDD ((nn == 99,, ooxxyyggeenn bboombb))"7. TThhiiss ggoooodd aaggrreeeemnecnntt bbeettwweeeenn tthhee ttuwoo mmeetthhooddss suggests that a significant portion of the serusplasa: organic fluorine suggests tha~ a significant portion of the serum/plasm.~ organic fluorine 1s not perfluorooctancate since one would then expect iigher values by is not perfluorooctanoate since one would [hen expect ~igher values by tthhee bboosmbb ~thaann ooppeenn aasshhiinngg.. IInn ffaacctt,, tthhee mmoosstt rreecceenntt rs~uslulttss8 bbyy aasshhiinngg sive a organic fluorine level twice that previously raporced?sh7. give a organic ~luor~c level twice that previously r.~ported2,3,7 TThheessee rreesseeaarrcchheerrss8 ffuurrtthheerr ccoonncclluuddee tthhaatt tthhee rraannggee oof[ ::oottaall fflluuoorriinnee ii~n Plasza has not changed in the past 20 years and that tiere is no evidence plasma has no~ changed in the past 20 years and that t~ere is no evidence for enviromental contantnation with organic fluorine. In considering for environmental contamination with organic fluorine. In considering these conclustons, 1c 1s necessary to realize chat one Ls comparing the these conclusions, it is necessary to real~ze that one is comparing ~he rreessuullttss ooff ddiiffffeerreenntt rreesseeaarrcchheerrss uussiinngg aa vvaarriieettyy ooff mvee::hhooddss.. PPeerrhhaappss tthhee mmoosstt iimmppoorrttaanntt ccoonncceerrnn hheerree iiss tthhee ccoommppaarrlissoonn.ooff oo~eenn aasshhiinngg ttoo cClloosseedd ooxxyyggeenn bbo~ohb rreessuullttss.. IItt iiss kknnoowwnn tthhaatt ooppeenn aasshhi[nogg iiss pprroonnee ttoo ccoonnttaammiinnaattiioonn wwiitchh iInnoorrggaannliacI?0 aass vweellll aass oorrggaannitce ((FFRREEONSSHR))?3 ffll~uoorriinnee aanndd thhaatt fflluuoorriinnee rreessuullttss aarree mmeetthhoodd ddeeppeennddeenntti1O0r'illi.. itnn aaddddiittiioonn,, aasc stated above, open ashing is susceptible to low recovesy of organic stated above, open ashing i~ susceptible to low recove:y of organic fluorine due to loss (volatility) of organic conpound srior to decomposi- fluorine due to loss (volatility) of organic compound ~rior to decomposi- tion; thus open ashing has both positive and negative irrors. Due to the tion; thus open ash~ng has ~oth positive and negative ~rrors. Due to the paucity of values deternined vith the oxygen bosb, it s necessary to use paucity of values determine~ with the oxygen bomb, it -s necessary to use open ashing results of questionable value for purposes of comparing open ashing results o~ questionable ~alue for purposes of comparing oorrsgaanniicc fElluuoorriinnee bblloooodd levels. levels. 11223344..00000066 33MMAA1100003344998800 5 CCoommppoouunnddss ccoonnttaaiinniinngg oorrggaanniicc fFlluuoorriinnee have have a a nusbe numbe:: of of useful useful iinndduussttrriiaall aanndd mmeeddiiccaall aapppplli~caattiioonnss1i2?.. TThhee wwiiddee uussee of of these these compounds compounds gives a number of sources for exposure to organofivorin: coapounds. gives a number of sources for exposure to organofluorlne compounds. A A rreevviieeww oonn oorrggaanniicc fflluuoorriinnee covers covers blochemistryl?, biochemistry13, ano:hor ano:her gives gives special special ceampphhaassiiss ttoo tthhee ffiieelldd ooff ppseyycchhiiaattreyy1l4d,, while while others others present pre~ent toxicology toxicology 0da2t0a5115~1166. The Fluoroocganic compounds methoxyflucane ind halothane The fluoroorgani compounds methoxy~Inrane and halothane aarree aanneesstthheettiiccss17? wwhhiillee aarrttiiffiicciiaall bblloooodd concatns contains perfliorocarbons1%. perfluorocarbons]8"]9. IInn aaddddiitciioonn,, sseevveerraall nnaattuurraall ssoouurrcceess have have also also been been sugiested'. suggested3. IInn rreecceennttllyy ppuubblliisshheedd rreesseeaarrcchh on on exposure exposure to to fluoochemicalsd, fluo~ochemicals20, elevated serum organic fluorine levels were found in chimical employees elevated serum organic fluorine levels were found in chemical employees handling o specific fluorochenical (perfivoroostancic a:id, amoniun salt, handling a specific fluoroehemi=al (perfluorooctanole a~id, a~monium salt, CyEySCOHD. Tn addition, that report indicates that his fluorochentcal C7FIbCO~N~). In addition, =hat report indicates that =h~s fluoroehemicml iisS sslloovwllyy eelli~nmtinnaacteedd ffrroomn the the body. body. Therefore, it wouli appear that Therefore, ~ woul~ appear that bblloooodd lleevveellss ooff oorrggaanntiec ffll~uucrelinnee are are dependent dependent on on the the possibility p)ssbility and and frequency of exposure to specific fluorochemicals. frequency of exposure to specific fluorochemicals. IItt iiss kknnoowwnn tthhaatt wvhheenn mmaann2d0,, rraatt,, or or monkeyZ! monkey21 1s is exposed e~posed to to che the fluoroorgantc, perfluorooctanofe acid, ammonium salt, this compound will fluoroorganic, perfluorooctanoie acld, ammonium salt, this compound will bbee ffoouunndd iinn tthhee bblloooodd serus. serum. This is not surprising vhen one considers This is not surprising when one consi4ers che results of a binding study of perfluorooctanoic acid to human serus the results of a binding study of perfluorooc~anoic acid to human serum6 wwhheerree iitt wwaass rreeppoorrtteedd =shhaatt greater greater than than 99 99 7 % of of this ~his added a4ded organic organic fluorine fluorine was bound to serua constituents. The above ciced literature?:3728:% was bound to serum "ould suggest that ecsosnsetnittiuaelnltys.eveTrhyeoneabo0v9e8 c7i)tedhaslltboetrhatufroer2m"s3'o7f"8f'l9uorine ~~'ald suggest that essentially everyone (>98 %) has both forms of fluorine ia choir blood and chat the reported values ace soneshst dependent on in ~he~r blood and that the reported values are somewhat dependent on tthhee mmeetthhoodd ooff aannaallyyssitss.. The fnorgantc value is known to depend on diet The ~norgan value is known [o depend on diet 11223344..00000077 33MMAA1100003344998811 5 aanndd ddrriinnkkiinngg wwaatteerr wwhhiillee tthhee oorrggaanniicc vvaalluuee could could be be fafluenced influenced by by exposure exposure ttoo cceerrttaaiinn fflluuoorriinnee ccoonnttaaiinniinngg ccoommppoouunnddss ffrroomm both both nateral natural and and synthetic synthetic sources. While the widespread prevalence of organic fluorire in human plasna While the widespread prevalence of organic fluorite in human plasma was aitially suggested to be due to comercial sources, the literature was initially suggested to be due to commercial source~, the literature cciitteedd bbyy tthhee aauutthhoorrss aaccttuuaallllyy sshhoowwss a a decreasing decreasing concertration concertration over over a a ppeerriioodd ooff 1155 yyeeaarrss tthhoouugghh tthheeyy ssttaattee that that the the trend trend nay ma~ be be due due to to the the aannaallyyttiiccaall mmeetthhooddss oorr tthhee bblloooodd ssaammpplleess tthheemmsseellvveess2?.. 4s yet, we find no Ps yet, we find no ccoonncclluussiivvee eevviiddeennccee ttoo iinnddiiccaattee tthhaatt tthhee wwiiddeesspprreeaadd presence presence of of trace trace aammoouunnttss ooff oorrggaanniicc oorr bboouunndd fflluuoorriinnee iinn hhuummaann blood 51004 is is the the result result of of iinndduussetrriiaall fFlluuoorrooechheemniiccaallss.. Continuing studies will erhance our knowledge Continuing studies wi~l e~hanee our knowledge aanndd uunnddeerrssttaannddiinngg ooff oorrggaanniicc//iinnoorrggaanniicc fluorine fluorine levels levels in in man. man, ACKIOHLEDGHENT ACKNOWLEDGMENT VViicekkil BBuunnnnaellllee iiss aacckknnoowwlleeddggeedd ffoorr hheerr eexxcceelllleenntt 3laabboorraattoorryy asstscance. 11223344..00000088 33MMAA1100003344998822