Document EqvQ2LG78jgj2QwEZmNe4D0LV

3sMrtFLaUcOmRnOtCrHEoMvIeCrAsLrSoUBrMiInSSwIeOsN HR226 190 | 3M FLUOROCHEMICAL SUBMISSION TOXICOLOGY, EPIDEMIOLOGY AND MEDICAL SURVEILLANCE 2% 902). 2. 206/903 2690p. 3. RIE 1506 a. 226 /0kp. V& 15074 "Inter-Species Comparison of Mechanisms Fluorochemical Toxicity following Intraperitoneal dosingofperfluorooctanesulfonate (PFOS, T-6295) or ammonium perfluorooctanoate (APFO, T-6889) in Rats and Guinea Pigs and oral dosingofN-ethyl perfluorooctanesulfonamido ethanol (N-EtFOSE, T-6316) in Rats," 3M Medical Department Corporate Toxicology, DT15-A, May 24, 2004. Molecular Biology Study: Final Report, "Comparative Molecular Biologyof Perfluorooctanesulfonate (PFOS, T6295), N-Ethyl perfluorooctanesulfonamido ethanol (N-EtFOSE, T-6316), N-Ethyl perfluorooctanesulfonamide (N-E{FOSA, T-6868),Perfluorooctanesulfonamido acetate (FOSAA, T-7071), and/or Perfluorooctanesulfonamide (FOSA, T-7132)ofin [sic] Rats and Guinea Pigs following Oral dosing," 3M Medical Department Corporate Toxicology, DT-15-B, May 25, 2004. Amendmentto Final Report, "Comparative Molecular Biologyof Perfluorooctanestulfon- ate (PFOS, T-6295), N-Ethyl perfluorooctanesulfonamido ethanol (N-EtFOSE, T-6316), N-Ethyl perfluorooctanesulfonamide (N-EtFOSA, T-6868), Perfluorooctanesulfonamido acetate (FOSAA, T-7071), and/or Perfluorooctanesulfonamide (FOSA, T-7132) of in [sic] Rats and Guinea Pigs following Oral dosing," 3M Medical Department Corporate Toxicology, DT-15-B, July 16, 2004 (revising page 59). Cell Proliferation Study: Final Report (except for in-life appendix), "Cell Proliferation Study with N-Ethyl Perfluorooctanesulfonamido Ethanol (N-EtFOSE; 3M T-6316.11), Perfluorooctane Sulfonic Acid Potassium Salt (PFOS; 3M T-6295.16), and N-Ethyl Perfluorooctansulfonamide (N-EtFOSA; 3M T-7091.1) in Rats," Charles River Laboratories, TRC 1132-100, August 9, 2000 (amended November 8, 2004). In-Life Appendix, "Cell Proliferation Study with N-Ethyl Perfluorooctanesulfonamido, Ethanol (N-EtFOSE; 3M T-6316.11), Perfluorooctane Sulfonic Acid Potassium Salt (PFOS; 3M T-6295.16), and N-Ethyl Perfluorooctansulfonamide (PFOSA; 3M T-7091.1) in Rats," TherImmune Research Corporation, TRC 1132-100, May 2, 2000 (Appendix 1 to full report). "Evaluation of the Northwest Bioanalytical Method Validation Reports for PFOS and Related Analytes in Human Serum or Plasma in Meeting the Requirementsof the FDA CONTAIN NO CBI 3 A3MTTFLAUCOHROMCEHTNEOTMILCEATLTSEURBOMFIS1S18I/O0N5 Bioanalytical 2001. Method Validation," Quality Associates, Inc., QAI 405-503, December 31, [rose| rertuorsocanousrioin FIG19081. "ABlleaxdadnedrerca(ncUerniniPevrofelfuroMrionsonceitsaotnteasy)u,lfNoonvylemFbleuorri2d1e, M2a0n0u4facturing Workers," Bruce H. 6719071. `"WAemamnionngiRuamtsPFeorfllluoowrionogctOarnaolatGea:vAaggee,"EfPfaeuclt oM.n tHhienPdeFrOltAerPl(DausPmoantC)o,ncDeunPtroantti-o1n53in02P,ostDecember 2, 2004, 2