Document Eqpx8OLqQ1arwG9bz9mmXZnRR

FILE NAME: Chemical Abstracts (CHAB) DATE: 1932 DOC#: CHAB006 DOCUMENT DESCRIPTION: Abstract Originally Published in 1931 by Schuster 1980 Chemical Abstracts Vol. 26 nation of CaCl; and MgClj it may be possible to prevent the development of heart block and of sy. olic standstill from the injections. S. Morgulis The stimula\,on of gastric secretion by the amino acid hydrochlorides. I. Ex periments on men. J usamuro T agawa. Biochem. Z. 243, 330-43(1931).--When 100 cc. of 0.5 N HC1 was introduced into the stomach no stimulation of the gastric secre tion was observed. A similar quantity of 0.05.W glycocoll was also practically without influence, max. acidity developing after 2 hrs.; glycocoll-HCl, however, seemed to exert a small stimulating action, the acidity reaching a max. after 30 min. Practically all hydrochlorides of the various amino acids tested showed a secretory stimulating action, but the amino acids themselves are regarded as inactive. II. Experiments on dogs with a Pavlov stomach. Ibid 344-54.--HI. Experiments on men through the duo denum. Ibid 355-68.--Expts. on dogs with a Pavlov pouch also corroborate the fact that neither amino acids nor HC1 alone stimulate gastric secretory activity but that amino acid hydrochlorides are strong gastric stimuli. The amino acids which may exert some stimulating action in the stomach lose this effect when they are introduced into the duodenum. On the contrary, 0.05 N HC1, which has no secretory effect when introduced into the stomach, does exert such a stimulating action from the duodenum. d-Glutamic acid-HCl has the strongest stimulating effect on the gastric secretion. S. Morgulis Influence of bile acids on glycerophosphatase. II. H irosi T akata. J. Biochem. {Japan) 14, 439-45(1932).--The administration of cholic acid promotes the synthesis of glycerophosphoric acid by the liver and kidney, almost in direct ratio to the quantity of added cholic acid. The stimulating action on the glycerophosphate synthesis is greater in the kidney than in the liver. S. Morgulis Biochemical studies on hydrocyanic acid. VII. The cause of hydrocyanic acid hyperglucemia. Fumio K udo. J. Biochem. {Japan) 14, 447-61(1932).--HCN pro duces very slight hyperglucemia in rabbits whose suprarenal medulla has been curetted, and it is concluded that the hyperglucemia is due to an increased outpouring of adrena line because of the asphyxia. In HCN poisoning it was found on a toad prepn. that the blood adrenaline was about 1:1,000,090 or 1:10,090,000. S. Morgulis Studies on the hypoglucemic action of bile acids. K eizo T anaka. J. Biochem. {Japan) 14, 403-73(1932).--Apocholic, dehydrocholic and dehydrodesoxycholic acids have the same hypoglucemic effect as cholic or desoxycholic acids, but neither cholanic nor cholatrienic acid has such an action. Conclusion.--It is the secondary ale. or the ketone group of the bile acid mol. which is responsible for the hypoglucemic effect. S. Morgulis The monocytosis produced by the injection of carmine, India ink and several other substances in the ear muscles of rabbits. T adao Saito. Folia Hematol. 46, 59-92 (1931).--A monocytosis is produced by the above procedure and is parallel to the inflammation produced at the point of injection. Subcutaneous or intravenous in jection in the rabbit ear also produce a monocytosis, but it is less marked. Ear exts. from carmine-injected rabbits produce a monocytosis when injected into other animals. J ohn T. M yers The anticarcinogenic action of dichlorodiethylsulfide (mustard gas). I. Beren- dlum J. Path. Bad. 34, 731-40(1931).--'The inhibition of the induction of warts when mustard gas is added to a carcinogenic tar is due to some local action on the tissues causing the latter to become refractory to the action of the tar. This refractory state begins almost as soon as the gas is applied and subsides very soon after it is dis continued, and has no effect on the continued growth of the wart. The inhibition seems to be due to a sp. chem. action of the gas on the tissues. J ohn T. Myers Pulmonary asbestosis in the dog. N orah H. Schuster. / . Path. Bad. 34, 751-7(1931).--Naked fibers of asbestos were found in the lungs. There was a fibrosis, probably the result of the toxic action of the asbestos, a combined silicate, and not a tnech. effect. . . J0H^ Myers Photobiological studies in chemotherapy. I. Light-sensitized trypanosomes in the trypafiavine treatment of animals. N. von J ancs6. Zenit^ Bakt. Parasilenk. 1 ,122, 388-400(1931).--Treatment of trypanosomes with parafuchsin causes them to bind less trypafiavine than untreated cells. The chemotherapeutic effects of tryparosan, As and Sb prepns. are also inhibited by parafuchsin and other triphcnylmethane dyes. In the dark field, definite differences are seen in trypanosomes under the influence of trypafiavine in the case of untreated cells and those treated with parafuchsin. In untreated cells the blcpharoplast becomes distorted, while there is no change m the treated colls. J ohn T ' Myers A "therapeutic" milk. R aoul L ec o q . Ann. fats. 24, 547-9(1931).--A so-called