Document Eqgo6bGnBdpLB3qXdqrzx95zL

h P ENVIRONMENTAL HEALTH PERSPECTIVES Volume 49, March 1983 U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service National Institute* ol Health / s/s. /: ppu- h P URL 04987 David P. Rail, Director, National Institute of Environmental Health Sciences EDITORS George W. Lucier Gary E. R. Hook BOARD OF EDITORS John R. Bend Colin F. Chignell Robert L. Dixon Hans L. Falk Robert A. Goyer Larry G, Hart Joseph K. Haseman David G. Hoel James E. Huff Burke Judd Heinrich V. Mailing H. B. Matthews Ernest E. McConnell Janies D. McKinney Clifford L. Mitchell John A. Moore Warren T. Piver Conrad B. Richter Raymond W. Tennant EDITORIAL REVIEW BOARD Phillip W. Albro John Bachmann J. Carl Barrett Stephen C. Bondy Gary A. Boorman Arnold R. Brody Rajendra S. Chhabra Gary Clemons Terri Damstra Jack H. Dean Richard P. DiAugustine Robert T. Drew Thomas E. Eling Richard B. Everson Lawrence Fishbein Bruce A. Fowler Donald Gardner Joe W. Grisham Frank E. Guthrie James R. Hass Victor Hasselblad Ernest Hodgson Michael Hogan David J. Holbrook David G. Kaufman Carole A. Kimmel George M. Kingman Albert C. Koibye, Jr. Kenneth S. Korach Martin R. Krigman Donald I. McRee Tom S. Miya Robert A. Neal William C. Nelson Richard M. Philpot Herbert S. Posner Robert M. Pratt Jerry M. Rice Walter J. Rogan Seamus A. Rooney Michael D. Shelby William Sheridan Robert E. Staples Velimir B. Vouk Michael D. Waters Hanspeter Witschi Errol Zeiger EDITORIAL STAFF Dorothy L. Ritter Assistant Managing Editor Ruth Krigman Copy Editor CONTENTS URL 04988 Second International Conference on Carcinogenic and Mutagenic A-Subetituted Aryl Compounds F. F. Kadlubar and F. A. Beland Preface............................................................................................ 1 J. A. Miller and E. C. Miller. Some historical aspects of N-aryl carcinogens and their metabolic activation ......................................................................................................................................... 3 R. A. Cartwright Historical and modern epidemiological studies on populations exposed to Nsubstituted aryl compounds............................................................................................................... R. Kalo, T. Kamataki and Y. Yamazoe.N-Hydroxylation of carcinogenic and mutagenic aromatic amines.................................................................................................................................................... 13 21 G. J. Mulder and J. H. N. Meerman. Sulfation and glucuronidation as competing pathways in the metabolism of hydroxamic acids: the role on N,O-sulfonation in chemical carcinogenesis of aro matic amines.......................................................................................................................................... 27 T. V. Zenser, S. M. Cohen, M. B. Mattammat R. W. Wise. N. S. Napp and B. B. Davis. Prostaglandin hydroperoxidase-catalyzed activation of certain Af-substituted aryl renal and bladder carcino gens ...................................................................................................................................................... '' 33 C. M. King, and I. B. GlowinskL Acetylation, deacetylation and acyltransfer.................................. 43 H.-G. Neumann. Role of tissue exposure and DNA lesions for organ-specific effects of carcino genic fTWW-4-acetylaminostilbene in rats........................................................................................... 51 B. Ketterer, B, Coles and D. J. Meyer. The role of glutathione in detoxication................................ 56 J. A. Hinson. Reactive metabolites of phenacetin and acetaminophen: a review............................ 71 J. D. Scribner, B. Woodworth, G. Koponen and E. H. Holmes. Use of 2-acetamidophenanthrene and 2-acetamidofluorene in investigations of mechanisms of hepatocarcinogenesis.............................. 61 J. G. Westra. A. Visser and A. Tulp. Binding and repair of 2-acetylaminofluorene adducts in dis tinct liver cell populations.................................................................................................................... 87 M. C. Poirier, B*A True and B. A. Laishes. Determination of 2-acetylaminofluorene adducts by im munoassay ............................................................................................................................................ 93 C. N. Martin, F. A. Beland, J. C Kennelly and F. F. Kadlubar. Binding of benzidine, A-acetylbenzidine, A^V-diacetylbenzidine and Direct Blue 6 to rat liver DNA...................................................... 101 R. M. Santella, and D. Grunberger. Induction of the base displacement or Z conformation in DNA by A-2-acetylaminofluorene modification................................................................................................. 107 P. Rio, B. Malfoy, E. Sage and M. Leng. Conformation of oligonucleotides and nucleic acids modi fied with 2-aminofluorene or 2-acetylaminofluorene.............................................................................. 117 F. A Beland, D. T. Beranek, K. L. Dooley, R. H. Hefllch and F. F. Kadlubar. Arylamine-DNA ad ducts in vitro and in vivo: their role in bacterial mutagenesis and urinary bladder carcino genesis ....................................................................................................................................................... 125 R. P. P. Fuchs, N. Schwartz and M. P. Daune. Analysis at the sequence level of mutations induced by the ultimate carcinogen N-acetoxy-N-2-acetylaminofluorene........................................................... 135 S. S. Thorgeinson, L. C. Erickson, C. L. Smith and L B. Glowinski. Genotoxicity of A-acetylarylamines in the S&lmonella/hepatocyte system......................................................................................... 141 L Oglesby, C. Hlx-Baker, P. MacNair, M. Sieg, L. Snow and R. Langenbaeh. Activation of aromatic amines to mutagens by bovine bladder and liver cells..................................................................... J. A. Swenberg, D. E. Rickert, B. L. Baranyi and J. I. Goodman. Cell specificity in DNA binding and repair of chemical carcinogens.......................................................................................................... S. C. Strom, R. L. Jirtle and G. Mkhalopoulos. Genotoxic effects of 2-acetylaminofluorene on rat and human hepatocytes............................................................................................................................. L. Eriksson, M. Ahluwalia, J. Spiewak, G. Lee, D. S. R. Sarnia, M. J. Roomi and E. Farber. Distinctive biochemical pattern associated with resistance of hepatocytes in hepatocyte nodules during liver carcinogenesis...................................................................................................................... D. MaJejka-Gig&nti, C. L. Ritter and C. N. RyzewakL Pathobiologic and metabolic aspects of mam mary gland tumorigenesis by N-substituted aryl compounds.......................................................... J. Russo, L. K. Tay, D. R. Ciocca and L H. Russo. Molecular and cellular basis of the mammary gland susceptibility to carcinogenesis..................................................................................................... G. T. Bryan. Pathogenesis of human urinary bladder cancer............................................................ 147 155 165 171 175 185 2017^ S. M. Cohen, R. E. Greenfield and L. B. EUwein. Multistage carcinogenesis in the urinary bladder. M. Ito, S. Fukushima, T. Shirai, N. NakanishL, R. Hasegawa and K. Imaida. Modifying factors in urinary bladder carcinogenesis................................................................................................................ M. Nussbaum, E. S. Fiala, B. Kulkarni, K. El-Bayoumy and J. H. Weisburger. In vivo metabolism of 3,2-dimethyM-aminobiphenyI (DMAB1 bearing on its organotropism in the Syrian golden hamster and the F344 rat......................................................................................................................... Abstracts.............................................................................................................................................. 209 217' 223 233 URL 04989 Contributed Article H. Babich and G. Stotzky. Developing standards for environmental toxicants: the need to con sider abiotic environmental factors and microbe-mediated ecologic processes.............................. 247 Published Volumes of EHpT....................................... . ............................................................ " ~. 261 Instructions to Authors........................................................................................................................................ 263