Document EqdwBX4vebDw2KaZj41zG6b64

N13240 as an outgrow th o f ex p e rim e n ta l work on le a d a b s o rp tio n and le a d p o iso n in g w hich had been c a r r ie d on in the D epartm ent of P h ysiology s in c e 19^5* The la b o ra to ry b u ild in g and i t s fix e d equipm ent were made p o s s ib le by a g i f t o f $130,000,00 made to th e U n iv e r s ity j o i n t l y by th e E th y l G aso lin e C o rp o ra tio n , E* I , duP ont de Nemours and Com pany,. and G eneral Motors C orporation through i t s F r ig id a ir e C o rp o ratio n , The e n t i r e b u d g e t o f th e l a b o r a to r y is made up a n n u a lly by fu n d s sup p lie d to th e U n iv e rs ity by i n d u s t r ia l o rg a n iz a tio n s whose problem s in occupational or public hygiene are accepted as su ita b le fo r inves t i g a t i o n in a u n i v e r s i t y . Up to th e p r e s e n t tim e , th e m ajo r p o r tio n o f th e bxidget has come from th e E th y l G a s o lin e C o rp o ra tio n in su p p o rt of an ex ten siv e in v e stig a tio n of the occurrence and the a c t i v i t i e s of le a d compounds w ith r e la tio n to p u b lic and in d u s t r ia l h e a lth . A d d itio n a l f i n a n c i a l su p p o rt was p ro v id ed f o r a tim e by the F r i g i d a i r e C orporation to defray the expense of c e rta in stu d ies of the occupational and p u b lic h e a lth asp e c ts of the m anufacture and use of v ariotis m a te ria ls '' <. as r e f r ig e r a n ts . S t i l l o th e r funds have been d e riv e d , from time to tim e , from E, X, duP ont do Nemours and Company, and c e r t a i n o f i t s s u b s id ia rie s , to cover the co st of the in v e stig a tio n of the to x ic o lo g ic \ p ro p e rtie s of m a te ria ls v a rio u s ly employed as r e f r ig e r a n ts and o rg an ic s o lv e n ts . The la b o ra to ry s t a f f c o n s is ts o f te n w orkers w ith g e n e ra l or s p e c ia l tra in in g and experience in in v e s tig a tio n , and e ig h t te c h n ic a l a ssista n ts of various types. KE Oi i A ( M c e rta in phases of the experim ental program have reached a sta g e w herein th e r e s u l t s o f s e v e r a l y ears* work have come to f r u i t i o n By re a s o n of th is o rg an ic c o n tin u ity of in v e s tig a tiv e work i t is im p o ssib le to d efin e sh arp ly the accomplishments of a two-years* period In order to be r e a l is ti c th e re fo re , and to avoid re c k o n in g w ith fu tu re s , however pro m isin g , i t seems b e s t to d ea l only w ith work a c tu a lly d o n e.w ith o u t tak in g in to account th a t which Is planned or in progress The I n v e s t i g a t i o n o f le a d and i t s a c t i v i t i e s has r e s u l t e d In e s ta b lis h in g c e rta in f a c ts which have a profound b ea rin g upon methods and p o in ts of view In I n d u s tr ia l m edicine and hygiene The m agnitude of human le a d a b s o rp tio n and le a d e x c re tio n u n d e r c e r t a i n p r im itiv e (n a tu ra l) c o n d itio n s, under the co n d itio n s which p re v a il g e n e ra lly among th e p o p u la tio n o f th e U n ite d S t a t e s , and u n d e r o c c u p a tio n a l c o n d it'ons in c e rta in lead trad es has been put upon a sound q u a n tita tiv e b a s i s . The e f f e c t s o f t h i s b a s ic in fo rm a tio n a r e t h r e e - f o l d ; I t fu rn ish es a p r a c tic a l and u se fu l estim ate of the gross In flu en ce of p re se n t day methods In h a n d lin g , p ro cessin g and d is tr ib u tin g food m a te r ia ls upon th e le v e l o f human le a d a b s o rp tio n and e x c r e tio n o u ts id e the lead tra d e s, and thereby provides a b asis fo r the reco g n itio n of fu tu re a lte r a tio n s in the American environm ent w ith re s p e c t to le ad exposure; i t s e ts up accurate and repro d u cib le standards fo r the d if f e r e n tia tio n of "norm al" persons from abnorm al, w ith re sp e c t to lead in ta k e , ab so rp tio n and ex c re tio n thereby g iv in g m a te ria l a id In the diagnosis of lead in to x ic a tio n ; I t e sta b lish e s a te n ta tiv e but lm nediatel; a motor f u e l, has been under In v estig atio n * In f a c t , the n e c e ssity o f s e ttin g up stan d ard s fo r the in te rp r e ta tio n of th is problem in p u b lic and occu p atio n al h e a lth has been an Im portant fa c to r In determ ining the scope of the e n tire study* At p re se n t, th is la b o ra to ry Is the o n ly so u rc e o f new In fo rm a tio n on t h i s s u b j e c t , and I t s c o n c lu s io n s have a vjide in flu e n c e in th is co u n try and abroad in shaping the p o in t of view and the a c t i v i t i e s , w ith re s p e c t to th is q u e s tio n , of those who a re r e s p o n s ib le f o r i n d u s t r i a l and p u b lic h y g ie n e . D uring the p a s t two y e a rs th e o ccu p atio n s c h ie f ly concerned In th is m a tte r have been r e - l n v e s t i g a t e d by nev m ethods and w ith a p r e c i s io n and c a re com* m en s rate w ith th e r e s p o n s i b i l i t y o f th e la b o r a to r y * The d a ta a re ' being assem bled and analyzed now, and w ill be p u b lish ed a t an e a rly date* O ther work of th e la b o ra to ry has been concerned w ith the study of the to x ic o lo g ic I a c tiv ity of various organic and in o rg an ic f l u o r i n e compounds* W ith in th e p a s t two y e a rs t h i s h as le d to th e in v e s tig a tio n of the e ffe c ts of c e rta in i r r i t a t i n g a c id gases of which h y d ro flu o ric a c id is th e only one com pletely stu d ie d a t th is time* That p o rtio n o f th is work which has been p u b lish ed p o rtra y s the e f f e c ts o f exposure to r e l a t i v e l y h ig h c o n c e n t r a t i ore o f t h i s gas* The m a t e r i a l y e t to be p u b lish ed i s a s ig n if ic a n t c o n trib u tio n to n knowledge of th e . b eh av io r of flu o rin e in the anim al organism . A method has been developed f o r the d eterm in atio n of flu o rin e In organic m a te ria l, which has been accep ted as a d i s t i n c t improvement over p rev io u s methods*