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MESSRS. P. F. DEISLER, JR. R. D. MUIUNEAUX May 3, 1979' The attached news release of tumors produced by one-time exposure to massive exposure to VCM illustrates the need for the "pulse-dose1* studies on benzene in the API-PS7 program under review. Attachment C. W. SMITH see 1-0701 r loy'?. Consumer Product Safety Commission - Washington. D.C. 20207 Media Relations Media Inquiries: 202/634-7780 79-19 FOR RELEASE THURSDAY APRIL 26, 1979 CPSC CANCER STUDY SUGGESTS NEW POTENTIAL RISKS WASHINGTON, D.C. (Apr. 26) -- The conclusions of a $700,000 cancer study conducted for the Consumer Product Safety Commission indicate for the first time that inhaling a single high dose of a known carcinogen may cause cancer in animals. < The study findings, which are preliminary and currently undergoing review by other government cancer experts, were the result of more than four years of testing and analysis of the effects on animals of high doses of the chemical vinyl chloride. These findings were discussed earlier this month during a meeting of the federal government's Interagency Collaborative Group on Environmental Carcinogenesis. During the testing, vinyl chloride monomer (VCM) was administered in single - and multiple doses to laboratory rats and mice as part of a lifetime cancer study and a multi-generation reproduction study.' Doses of VCM in the form of a gas were inhaled by the lab animals. The study concluded that the carcinogenic effects of VCM depend upon concentra tion and exposure time, and, most importantly, that single (one-hour) exposures at high dose levels (30,000 ppm and 3,000 ppm) of this known carcinogen can produce tumors in laooratory mice. Previous ilusively on the effects of repeated low-level and high-level exposures to carpinogens over lengthy time periods. -More- RhCElVtu D1AMONL shamrock kaY 1' 1979 0. P. HARlOW WLSrl.NOTOo, D.C. see 1-0702 'T 2- - Dr. Joseph McLaughlin, Jr., the project supervisor for CPbC, said the study . is the first to assess the effects of such short term exposure. Vinyl chloride was chosen as the most appropriate chemical for the CPSC study because much already had been learned about the chemical's carcinogenic effects on animals and humans through previous tests and studies. The VCM study, which began in early 1975, was conducted by-Dr. Bernard McNamara and his staff at the Chemical Systems Laboratory (formerly the Edgewood Arsenal at the Aberdeen Proving Grounds in northeastern Maryland}. Following the one-hour exposures to the high doses of VCM gas, the laboratory mice and rats were allowed to live their normal life span and then were sacrificed and examined in path- l* ological analysis for evidence of tumors. Pulmonary tumors, both adenoma (benign) and carcinoma (malignant), were common in the mice which had been subjected to single high level doses (50,000 ppm and 5,000 ppm) of VCM. The test.conclusions showed tumors in the mice only (and not in the lab rats). The VCM reproduction study conducted simultaneously did not demonstrate mutagenic or teratogenic effects in generations of the laboratory animals. Theconclusions of the CPSC study suggest that further short-term high-dose studies of other known carcinogens may be appropriate for government and private researchers. Until several years ago, vinyl chloride was used in a variety of products, primarily as a propellant in aerosol products, ranging from spray paints and solvents to hairsprays and pesticides. Medical studies of workers in the early 1970's which associated vinyl chloride exposure with a rare form of liver cancer (angiosarcoma) resulted in a commercial ban on the chemical by several federal government agencies m 19/4. CPSC banned consumer product aerosols, such as spray paints, containing vinyl chloride monomer as a propellant or an ingredient. The Food and -More- SCC 1-0703 -3- Drug Administration banned VCM from hairsprays and cosmetics, and the EPA banned the chemical from use in pesticides. OSHA also established restricted workplace exposure levels for VCM, which still is used by various U.S. industri-es to produce polyvinyl chloride, a plastic in widespread use. '' The study's findings further support the thesis that a single exposure to a high dose of VCM, or perhaps other similarly acting carcinogens, could pose a risk of cancer to humans. This suggests that a one-time exposure occurring, for example, as a result of an accidental spillage of VCM on the nation's highways, railways, or waterways, could threaten workers at the spillage site, public safety personnel, and perhaps even nearby residents. Scientific review of the study and its conclusions will lacilitate the assessment of the regulatory impact of the VCM study on various government agencies. This review and eventual publication of the study in medical publications also is expected to stimulate further research in other health areas by governmental, industry and academic experts. .Scientists and members of the press who wish to receive copies of the draft summary report of the Commission's VCM inhalation study should write to CPSC's Office of the Secretary, Room 300, 1111 ISth Street, N.W., Washington, D.C. 20207. The telephone number for the Office of the Secretary is (202) 634-7/00. (For further information, contact John Bell, CPSC Director of Media Relations, 634-77S0).. -30- scc f --0704 i"0705 90Z0-T 03S au| 'ssiJoiejoqET ASoioqirj |rju3UJU9dx3 1 J3 \ \ (AV/Jzr* (fi'U)CLI ('^W 7^> (js-fyzlt (zsc^'t) [%f>C/K/ry (%*/?{.*-? 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V PO n 'V'P- /x */'.< p?*1 /3 /r / -**? .5 /i * -.t 7 -- (s 1 //' , . /* s* 'r 0 /pf1 ?n'' -- */*/>'/ EPL Experimental Pathology Laboratories, Inc. , L see i "0730 T/SS.UB U/e/Ajft/Sy V-TiCus - 7or/?t TCr 7c7ftl. 7/SScS/? P&C. fiecfcca y<*1sn/*>{ /DO u & 7000 f. 1 \ j.-. r .* >. //'v' ' ^ f* '" i O / "V \y , ;/ 3-3% 4l Fl Experimental Pathology Laboratories, Inc. \ see 1-0731 /; * /* >? v / / /ssoa. U>Amc <ZC7?A)L> BopJe (V) RPS (VPmeAt. >s} V. Goa3ads ktrvoe't'j Cec<un\ * ^LoCd/O Lius/L i-y/u &s Uy/vi^H ajuo<?c /V) CVYtC Pa)CjC/75 PflC/77^S?/0 &ts?AJ& ,PlTt>tT<4rCV 64/7AJts semjtr'AC* isz.i cc ^SKltsJ \ Devo t>r\tun^. 7eyuoj c//rv. ^PLrtJ S~fOS77 rttH THYmuS, THyZoio 'T/=}CH/3 ToT^L -& Tissue f7lNb/T/n/?cJ.S 7or/9C Ttssve ffirotoc ooo Y OO foo /<?o -?,cV) /rv' .7 OcO 7 o.O /O0 /c?> / r>0 2CQ , /oO /O o /J2>0 /<? > /OO /o o /oo ./ / r') r\ `.yO ' 7 .' \f'0 'OO -r'c / -:') n n q u o 70 12 Hi (*Z n n 61 71 11 to , P3 O M n n fl n \u //> (0 . It 9/&c?3 *9* &3 n 6S 5 75 73 <?cl ^ 7Y 7Y 3 XT' &0T 30*-* 1C* #3 3*3 /V o r-' a*/* ^v4, cV'/ N` 73 j?r / -?*o$ EPL Or ~J >' C<) /D>S. Experimental Pathology Laboratories, Inc. % \ft see 1-0733 :.F. -- 7^ ni/Htr T3 / /SSo. TTIoSTSrUfLES-A* G7bMT//f(rct/.yiS Pet fl5>T0C6t x/i/?7/ivez> T7ibssr/u?ec rdr&aj&c- ats^Ajos. BoiJ (V) I3oNH MA&G,0eJtJ (sr&CAtMH^ 1: Qg$ ('ZVmQAL C, ESOptf&cuS. Ga/Oads Ce<2^ (LotaaJ L\ud_ i-y/u os LyrTtPH /U^btc ^V) CPYiC N<s#i/ PflrtC/7S Pfcz#r'//y&/c> &C/JAJ& ,FlTuiT/(C^ P0$.TATG ~SAt4S&+?Y serrtntot iSjfs. / cCS. S A/<v ' DGOo l>r-JVry^ zreT'uro u/v~Z`Ltirf\ SYosne&H -THimuS TT/tf>iy?ZCoHio/4 s>oO y 00 fa o too /DO to 0 o.a 6 poo >oo /eo /DO /oo r) /oo fr\ 0 /; /)30 ' 00 /:) a ! /;/ (OO .-O') too ' rOO l 00 (OO (0 0 [OO -.. > ~ 7 3 & o a 3 iT" 37c>? r 3 7S ?y o? o A/ o 7 '3 y __ 3 3 -3q* N..' <2 7/ O o o'? -7 cpy o 73 7`/ 3'/ 36 ^3 ^ - .a 3 36 j>y 7/ ^cv(rt 3 1 3 O /?7 >v:^ -. . >,` FT seo z C-f*i ' * /*' EPL wcmCCk r ^ '"T'h t6>3 Experimental Pathology Laboratories, Inc. SCC 1-0736 - \1 / . T/s^ua. OT&/C03 Tor^t rr 7VjCSo^S P&Z . .0 C 7e>7iQL 'cf'V/srr>/*lS 7/SScJf^ X/i*77/f*e:z. AWLmt- O V06C \ 9.^ ' V f * ' '0 0 \ 3* "x / - ll'.l"' c? -j; \ EPL Experimental Pathology Laboratories, Inc. 47 , ,vu see 1-0737 /1*>? 73 1-0738 X- \S~iL V 6iO-T 33S *ouj `sajjoitjoqt'i ASoioqiej inusuiijadxg -<> i .'S' cJL ji '(? :-P WHw -f,- ^C- 1d3 IV V />* V. *' r'Z -- -- h<? y- *. 1 L &e O ov i? (,/ Cp' 6 tf/ -- pi-' --- o -4/ //- /<?? J-Z. LL 3 w' / oo/ QL-; AO/ L- v -` .; ' ' 0 l-V' Vo / Q Vs O 0/ 02/ O Os QOJ (20/ OiP V 9o/ o o/ */z JL "GV <?/ ^>e oz Vi i*P GL (*? y?<<? As* o \<? Li O i? ^/ST <?<V (9 0/ QV'i? OQi OOi o o/ OO'C 3 <?/ 0 0/ ooh C>o^; flptrrnMV "&767UrOrUX <X?A92&Mr# ->c?02<& y?<J $-7Uu//Htj S-pnssU. &- 7ixtoj- t?9HQbi3_L QH&AHJ. H'9b>L*Oj.'$ O'sr&lj's WiX r^nxasL -w/irj$<g ansa ' rv/xs* ~&70t'sp/7 ?7<$tt/us$s- ^3rvfr-7? AarttPryps^ 3j-t*^03^ hwX\ox\J. <r/Yts7y a/<z?A//xvyvti S t/PZOWtt,-} &/typH 0*J-A 0 (^S) 3aQ<?/V HcM^A'T s<nun-t fvp-)o^7 r/>s(va\^ Sot#(vo9 =>^3 $nvt/H*OS3 <^<tMT?V 7b>9u#z) S 3fcf 3 ; Nfy^Q HNC?Q (A) awg ?arv<y7~> -?fc/r^5,cxt/ VOS'?/ f "loj'tvoj (vrf --U$ 3Hniiz/J EPL Experimental Pathology Laboratories, Inc. sec 1-0740 i, tL t. - t' A -- O/oOoAJ7rQoc_ rhB'L. OOoZxB. /H VLC t J? Pr/x.tP. sif/suiS7//1/BI,' o'-baiCj l! r i' i,t i x Mf/iR-T T6*oc* uz- - ^/>/o /S' /(& 91 /O 6*0 o -77 5<3 91 09 -7^ OO 79 <*?y 3 HO. \. / of nc o ;o i. . if61 fOA . DC. u ) r; Lir i, EPL Experimental Pathology Laboratories, Inc. ./ y SCC 1-0741 fG^r\te XfiT-- T l J /SSd- Yor^i. -*p YbT/9c Tbr&i. TISSUES T/SSUjS P fiCofodaL y#a7AVT> fU'wcfSce BoWfE (H) r^o O ^0o 7 6> /3 RK$ B SopH&Gt>S 100 /I o >50 /oO S' JO 7N o7 /S' 7'/ Y*= GetsIflos ;O0 t&0 r /3 37 o-x kvtsMrev'J doo o< Cecity CoL-srJ Liu&_ l-Utv Os L Vr>tPH /VtfCsCC (s^ &PfiC fiJV: PflA)CC/?S 100 100 f06 ft 0 *K .-V /ro /DO 7 7 Cr<. - c* 7 PJ 17* n* 'i-7 S' "* /n /o SC pa</?t'//y&>ic> &ts4Aj& l ou O 31** KPlTlHXAfZ^i Peos-r&rG 1 00 i oo 5" 1 -- SALtmaY CLAaJ >. 'Smifr'tot iss.jnt- 1 oO !Q0. /s> -- --- /.;v) y > OGUo J^&rJUrr^. YeYLsro uno-- -X.La/*\ SPc GSaJ fp /) /jn " -' /) > ."l /) 6. `S~</ /7# /7' >7* &*/ rt&H / n Y) "7 'V ~TH Ymas 7Wvb#o Yf=}CH/l i /? * T / n rZ J // "7 EPL ivvw\con / S-~ ''ll- r y > r-.\ : 1 Experimental Pathology Laboratories, Inc. . .C/ see 1-0742 IJ. -- JL&2f -vnW&z/ Ffn> nee Fn f -- / JS~Su. F\J>&AJrtc <FCF?Aj& i3o^t= ('v) (3^Me r>iF /?^0aJ (zVtneAL CLAA&h) EiofMflct/5 GV. GoaJads kit^Oev'j C.CtcVK {LaiarJ Ltu6/Z_ L-0/o &s _ LVi^tPK/Jo&cc (V) C PYi C FJ&ev: PflftJCCAS PftO?7'tf&jC> &*&> /iTbtrWfey Peosr^r^ H/GFY Cl^aj 0 iSs.icC. S K)F) \ Ueuo t>rJVtK, 7eT1/fU (JtT^ X C CriJ/r'l ^PCiit^ SYc /c>7 /=?A/y THfm 0$ 'TTtFttFfgcoFFtOFS "):. \). .v' /.1 7"f ;;Vin,;,Cg./-i''r/<L'. EP L Of FF '7T7bSTSrfOL ^^Fp Tbrstc P f%h&&c x/um*& l7*7U1oS'A7S/7CP?4&L4L ,:r?F *00 /00 FO S>o0 /oF too too J00 /:?o /A7 /O Z"1 -7 /o V JO V9 V /o 0 zn /r~ 7 V // 7 7/ lo 7/ V /Q* / - scr* 7^ m /> **; :*r\ A 77 _r" 77 . / vo /,) /) //V? / A /) {A 0 - 7 &*7 O aY4 <r^ Ji -- y /.-V /* '1 t <-t ^ *- 1 .> <y\ * u z/y . </ S //VI y ,'0 0 7 y /aan7 7 Z,,"77 i,,>7y' V / /'7y' j /3 ~-- /? yy /E?. /e? 77 // i? <7F1F Experimental Pathology Laboratories, Inc. see 1-0745 N^ /3* V = I / .O0I>t- /h u i c t *? r /-r.ip. /'jr&tst- S C-'o^r^ Jri-.urX 7v-_ J ^ s/f/f.t'>" f Tb*Jrh'Jtz 7 7 ----3 73 V7 V3 /i. 77w 77 ; 5*9 TS '7 n (^>(r PJr\ Xy s<J 8% ^>r< ^7 t'n'oSc'S EPL Experimental Pathology Laboratories, Inc. pK t fTX see 1-0747 / -IP / /SSo- -TT7bSTSrUfi&. JS& 9-T/4b/Tmrfo/V.S P. flSbTbtoC EX/?/?7ASE> 4Yrtot'4efts/L?u4c*t{L Ar>Amc ^>00 sr 3o>Je. (V) vCG i3oNfi fh/3 R.ouJ (sr^rJki^ 00 0- CJ foo a o eye. GonJ^os //? 0 /OO !0 o / o jz klta/OisVj Ce^tLVK C-GLarS a-yp /OO. ^* aVr*-\1. (jT\ o. J 67 i-^AJ frS roo 70 Ly7tPH AJtfDCC 6^ 0PT/C NSjevz O 'Vi 0 : PA)CC/?S ,nr> JR PftG/?7Wy&/0 &L/?ASP> 'a . ^ (3 .PiTLi-jwie*' /oo O f*eosrtAfG rSACltfG/CY 44x7/0 fcs Sm/nfaC S&.ict. (OO / 0f> /oo -- ---- SS./V ':->o / DGVo 2>CrJVrr>, ^TeTtft\J UiY^~ "X'LGur^X $Pl<U S7tf <r?7 rt&H -Tb4 9/nu<. TTh/RtyCgHoio/1 K- .V v/ /'**. /> ' .'oo } /oo 4 l , ''-`Vi > /A0 47 r> o 0 } `O? .:;\o ' / 2 ? * (' ~7''V7 f 'C 77; p> '* in/' 7//-.'/C,-*/>; EP L /S' /Cr S' n j2, 7r /<f 61 -77 -//sS.''4*: 7? -/?/,> .-' o /r &i y,y -* -- /*' -- 13 is* t. A"v' !7<27 J? 7.?. Experimental Pathology Laboratories, Inc. see 1-0748 Oy\r". v. ' C-X> V i /v 6t40-x DOS ^U| 'sauoiejoqr*) ASojoqirj |eiuajjj3dx3 1d3 o % 3 /\ % L' C /\ O'- b "V<-L~' bb'*'-' < / u9 'JWJ&tt/ fJOTT/J. S?t/U*//0'b/ ooy-z QO/ 00/ V3 <<?&/ ys'o^-y/j: ja ?&'*& ro^j-r? A&vfYt&o 'frf -- 73 fS/Vsn.a AVir_7-v J /SSO- ToTrfL -*P 7oT/?C Tor/jc 77SSU^ T'Ssv^ F fl&T&e&C BX/jmwei> #l'/1t.4*Sl \Z>Rrt&C. <Cs4/UOS BOhM= (V) <_VOC fro 0 S~ /O ma R.ouJ (ir&TA'Hmy RPS (z&rxGAL Cc/tovb) /r'ft fSS ^00 eve. Goajc>s ktC>AJSV-f C-ECuJfo (LoLofiJ LU)B&_ i-6Aj J>S L Vr>tPH (&^ O^TtC /slXl/ P&tOCCS/fS v^Zfirmecio at#a/& lPlTt>tT*4<V' Pe<07V3r<e s5ALli/fiPSy CL# AJt> S^rfiz/y^oc^ is#s.tcC. S K)tj *. DPo x>rjtsm. ^X&'Xl/ AJt/rt'S-- ~X-LBiAr*r\ SPt 6/L S7b/^7 H -TVYm uS Ttiygoto TkfV? 40 0 'cKO ,, ::vv"0 ; ->,"> .'3 cl? * J); _*0 ' ** "J (' /o^> //>r> .- '*) O 'V'3 Y -' * , -1 -\ * \ \ / &C2 /& 0 /<f>0 . -V ^ ,* ;A ft 6" 5" 0 0" V s' <r s' w // / &7 n: t*7 7p -V. 12 t3? 72 6- 3 V 0 */ --. <r --. vS ^7" 0r` s5^ OH s~ / Jp n3 5/ 7 a?"* -- /& -- /A .'"S v ' 'w' 70 }3 -?I7 // */ E PL . .-S' Experimental Pathology Laboratories, Inc. see i'0751 N ,rt: (U rhF-L. ,/Uot>. ps. c t >r/LYf' i:Pt /\u fpp/- $/}//ps-t O'-rf/c c.i :.} r p-p [ ;< sS's-S.-i"# ~. /.".o^fr C - -> / t ./* \ Hf. V/ r/ < 60 t0 Y *AJo o ><' PL Experimental Pathology Laboratories, Inc. \L )V-*3 see 1-0753 Ucm- &)ce / /SSu~ -ToT^L -& "ToT/lc 7b7U?- 77SSU^ GHJ/n/V-S T/Ssv* P& f&retcC Ejt#/T7*tffT> </-sQ/VLiS Bo^e. (y) e /rt R&ouJ Bftrt/w flS <S4>5^p^) BSoPH^GcfS G<daJ*c>& kii^iaVj r 1M OG OO os Ol 3. z ! (b. T o-L. f./- CeCiLVrs. Co.*5aJ Z,li;<_ J-tf/O &S LVi^tpn Ajot^et (s^ C^YiC N/Zi/ ^^CCC/Q s Pfl^/77'//Y&J& &L*aJE> .prrui PeoiT^r^c CL4*J*> Zmjfy'toc^ ^s/c6 Kltsj \ Veuo i>rJUrv^ '3'e'TisrOO/t'^LjSii/^ S7'#'7>7/`?/y TNfsru/s. Ttty&oso -rCfiCHGsl 'X- 33 EP L //'/7JT//J S d 3 5Zs/ o 0. y O 0 3. o . 0 3 ^1 3 vc. 0 G \ !\G C y -y . u O 3* . O o S' 3. (O 1. *r X 60 . s }. o & I 2__ Experimental Pathology Laboratories, Inc. see 1-0754 7 *' EP L Experimental Pathology Laboratories, Inc. see i-0755 90-t D3S `3U| 'sa)joicjoqci AaojOijiEj jnuaunjadxg & o Qj ZS -X 34 n S' b 8 0 0 Li Z *) J9 * * -0? 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'( | Wy&v'AM^'T ^'U1'50^ $1 V Ol-UbCL mM ^ l \5T TV L h l-J A t QVft'V \b,-r);'V- 1 AoP-Tf) Titles i.) 7 V \5 T . !- ft ft <r Tic-Sms I'YwnT UM'ftiti o in/0 5 --,_^ o_ ( ( ft St I in 0_ _. 57 o 6o o 1 fe. 6 13 o -O u( c] /5 oi o-. i ao > o V-- n_~TIT_ TH SLIH * 77f 15 ) l - PL Experimental Pathology Laboratories, Inc. see 1-0757 1 /SSUL lr* \zl(M f.C 7ToisTs#uLes-*P PK f&TotoC &7fbVTW/?c/V.S T/107fi*> TA7lt/ZsW>sLvrtAj??dt Le RbRBAi&c. a^/u&s J3owe. (V) GOMH fVlrt/?^0ctJ BfcAlN -. HAPS (Vn^e/K. CiL^Ajvs^ t= -Softf/g<;t/.S Y<=. GOfOflDS k\DA)eVJ iBCasfc CJatatO Lwe&. LOm i>s LYrtiPH AJdtfcffc (V) fV/6 Nl/ ^COOCCE/IS VbjlTHedit> GCrfA/P f\Xoi~TAlZ*{ Peozrare iSACJS/lteY CLA*Ut> semtobc* is*s.icc. SM/aj -. X?GOo *>rJUm. 7ej`L'fOUf*'-X.Lar*1 SP(.*J S7V>/^7 *AtH Thomas T7CHfiyCZHoi/oq Sl O1 oO O3 01 0 13 0 2 G SI- 6? ' 8Xa o. X 7o 0Z-- ?o- 82.- 0 33 0- o 3 V?3 rTi O o D'"l 0o i 5" oo f to - D V 0 O A- A y? O 7C<o-^?P . . O Of 0/ o7 EPL Experimental Pathology Laboratories, Inc. see 1-0758 EPL Experimental Pathology Laboratories, Inc. see 1-0759 ^3 AA&L& / /SSC/. ~ror*L y?ssoe=JS ToTrtc Tbrtfc EX/1/m*Z> AU/!t.44te 'PU>Amc acsQAjt).s Bo^e. (W) 6o/^ Ty\AR.ouJ (S/v^a'X/w^ A/n ` HRCS (^VmeAL E- som^Ci/.s GoaJ^c>s kttoMeVj o Q 0 o o o o 0 so 0 Sz. (G o \H- (o22. 136H- 7o- 3 0-OL^rO i~0fij &S i^yvnPH MObec CPfiC N<f/?i/: 0 M- S(. 0 o. / ,Y3/7/53- o 67- .pin>iT/4v Peos.7^r^ CL/lAJ fc> SGrrt/ffac* ISs.igC. >jr/Z/Aj 0 0 O'2_ 6 0 \ DGUo x>r*fUrr^ ^QTu t\y O/V-- 'Z'L&t4rr\ S>Pt(AJ A . L7 S7b/^7/<7A6/ -THfoivS Tuyzojo -tc/Ichga ' jjg7r> epl / aj T&Zrn-Ji-c 0 0 0 0 ______ ( Has o /2-' o /7- o /3' 4 4- *7167 o 1 JZ2L Experimental Pathology Laboratories, Inc. see 1-0760 Tor&c 7=r T/-S-S.U4S "rbrt<?*}*0/s**t/*S 7o7&l. 7sVfS P&Z fXoftta y/jsT7//v/T`: Ayfiu*ie. U?&/Cos a o ~~ o" (P CD (M<sizvPf'-}- Co A-T - (0 Q/hl E^mm V6 -it 3O ) i& AUSCL/? k\A-SAU QkWN sfuJA )- P of ^ ' f o /3 O IX o lV2O koP-Th To 7.) Or U F 12- T t r^ /" O O o o' 1 u o 0 TifSUP ';'/ '$$r , ('[,! k" 7-j-j.-iO /x 10 ;j o~ r" OX b '$ \ 76',; i> ';! '''>) i .V1 , P\ P L Experimental Pathology Laboratories, Inc. see 1-0761 UC P - mi c.(- P'7T7&bSTSfrVffftifoS-t*dPC 7bTs?- T/s7it/b'J/7ls/^to/?t^4CL fir>^eAj/4c <cs4>ajos BOhre (V) 9 OO -foo 1o <9 Om/Z^ouS ($f<6Crtnrn^ . /&-v o Z3/?fliU tff-o o ('zVmQAL 6Sbvi>?) Peru o G iof^GO-S eye. }{TV t> frz> o Go/OflOS J>OC> fo J> oO. CeccLVis. }T0 s (Lola*) Uwsfl. i~J/US /cri) (Y /crO V 5 /(TO Lf5 Ly/npn too bee <V) 3cn* ' .. O-pYtC M&evs: frd o . PPtrOCX!/y S /(TO H ?Q&!7?tY&iO &L/9AJ& piTbnwiev /in) o f&7> o Peoir^r^ /cn> --^- -SAUttafiy cc/tAj-o 'S&rt/ztjcc* lSs?s>JCl fen) j &z> o ---- JT Jtrz) >3 1 Oeuo *>rJVtn. /ao S . \TG'X'l/f\J UfY^ too s 5. 'K-ltStirn S*?lOrtJ 'THY/nvS TTCti^&gcotisio# fOO 8 too HI- fdO 17. /OO o /ZOOOO >> -J-L: 3 HZ. (t.rrgiS'nf-i^c -L? o <o ZL O 1 i ZB- n HH- HH. !j . 1- -?yo--^r 1. -- <0 -- 3- _v* -*-- H3 43. C> H- 12- P L Experimental Pathology Laboratories, Inc. rr*- = "Io' Ti{Y'f cm'o 0 > vJ -7- . /V 7ors?c rr To7>3t. */fsrt//vier_ U/?IAi fuQy l/P Or&jCuj> ' ^ L.-~- - <3 \\ /0'd IY- ------------- ___ -^... ZZ3> 3S O Hef^T 43O H3 0_ ( I <"? (oK^-l 0/^`Y <? <? 6b .CfflA-O Aoe-7> TOtsHU-lf TsT . f- IST^^ . Tfi^ue ^(4-Xr (IMKIOovXJ^ i Qtrfe-u l;x _____ . .o o o O O o O ,i 1 l fS 3 __Y 6 % 7TT7~T1) a,?c(o *> --- 1 -V, -. l5lly HO^ A 1y Svn^'-:t l epl Experimental Pathology Laboratories, Inc. see i-07 63 \\<* P / /Su- TbTrfl & -TbTrfc. T7SSv<S-S Tor's? c T'Ssve P fficsft&L EX/j/r7f#et> R&&ajhc <LsOaje> Bo^e. (V) rHi<i /Z^OUJ (srttT/VHrH^ HRpS fzJ+rjefl. CyL^n)i>S^ bsophwoS 6YGoaJds klE^jaVJ Cecu^\ .OL<1aJ LwefL i-Ote 9S l. yrn -ph AJytec (V) 6T>?tC H O r zz_ --- l ZT" 0 a / - . *N . .. ' - - - 1. 7 \%S. .'* O --.- - r~ r *' 75 77 -- 1 ;/. C" PflAJCC/?S pi Twfr/*y fteair^re ^Atn'aaY CLsjsjtz Se/TiJ/yfrt S<*s.tGt. JT kjtu - Vet>o x>rJUm. 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Deoo x>/vv/h. ^TstVaj c/m- % S7V> /V7 At>H YHi'/>uj<, ~tThCy&rCoHid/1 \ 7'( iM-ir-'r-? -(jo > -,: E P L \/V 5 TVrp Experimental Pathology Laboratories, Inc. o o 5 --- JZ: ~2~ z. 63pO 6" i 5 -- rv*.~' j%i t > 75 75 Z r s * > SCC 1-0766 7~sS U&iAjA/Qy /Zi/? OT/eoj 1Py7'cf/>sc7-/s>X?.potT^o7sCffi ^^vyAb/?sj/AssfTr?7+/t/-/MtitSec A7TyPorA'/*JUtLM*4t. 1 b'-i 75 "To HeM^T Cwvk>\) sc;i "7 3 q 0 3?, ^Wh^Lc Or^llTy' 15 r z_ <: Pe.fciPffg'RA-LDeit^Sr ^-o&r/v tonKui? O1 O ^> 0 "FffET .p . Tiifu e fl'W-tfxr 1 ({MKIOOvJJKi in - Qirfe-uV?< 4 ei n2. -?37 C~ ul **J IaT1' n V<" 1 / PL Experimental Pathology Laboratories, Inc. see 1-0767 i - 3 ~T~r. rAftu t- M 1CgT / /S<So- 'TbTM & 7bT/?c Tor&c T7SSUJS f)Nj/n*U.S T>SJU* P R&foeaL EXfj07fiVT> AUSV144L F{D^BAi rtC ^4^/LlDj; ('v) C3ong x>\a/2.ouj (st&cjvum^ Z5tfiW " S (7 VrrxeAL C, LAa)x>s^ E iotf/9G/-S eve. GoaJ^os kltSAJlS^J <3> O 0 o --------0 o / w (oH} 6. fX /Z>. II W v67' 72- CectevK oL<JjO -iuv3_ . i-u s Vr>ipH AJO&ff C ofYic s*/&ej/: PflA)CC/?S. s*:fn'Hoit> &c#Ast> . PlTw T* y* Peoi-raTG vSALtmiSY CLAAJb 3r*7t/yfrCjC l/&fcc. ^SM/fO i VVo &rJUrrv. 'Zf&Tu/\) Urt\~ '^LEuf^x &'for??'e3&H ~TH fsK V$ Ttiygoio -rescuea 'T'~ '~72L I *32,, ST 5T ( O: ..( -- o --- o :/_ ` ~7 2.' 7-2-' V IQ ` *-- 15' /- ! 1 i i: ^ ii / J) f"*\ ''rYV - \| M\ i J~* iq -rX % -x- 71 70 2_3* Tv7 EPL ' "Tv^w.i 7, <" Experimental Pathology Laboratories, Inc. - 69Z0-T ODS DU| `sauoitjoqrT ASoioqitj inuauiusdxg 3d3 t -r f CiL ----------V hi ^c; ----------- i t ) <. . -- ------------ .O <. ... . V W\ n!v ^- - \ ! / "Z\ - PV /7 1 M ` 1 V V }^ O o o <l /_ . O o r^n^r>(N>vNn XffJ-y]^ a 115 f IL. 5^1 ' i/3S4_ fnn^Qj_ iU-tso^f -V ^apnw^ch^cl ' i-n^'5 nv[/" A2tv<vt#n &4/ 7j/rS/izs&j;=/ *'->V<V >-3/ 7CtOC -7