Document EqOYEdZkDJeL5Ym4qeV6YyoGj

5 9 1963 IXAX> ETOTnrt AHP A ixnrrt k'juxriM *> 153 To IWMn of the iNd b&atrlN Association, Zno.i SHUT or SXD^taOTJ KECKXS IQS UU> At the present time there are four method* gaoerelly used for tasting load absorption la htaaa*. Thee* or* quantitative blood load, quaatltstlTC urlao load, urinary coproporphyria aod urinary delta-emlaol orullnla ocld. Thee* method* oro uoad with more or let* aueceaa by aoay Industrie*, health departments, hospitals, clinical lab*, ate. la oa effort to provide eclostlfla evaluation of tbaaa Method*, the 0.8. Pihllo Boalth Barrio*, la cooparotloa vlth tb* Ohio State Department of Boalth, performed thaoa four taeto 00 a total of 966 Ohio children aged free* 10 to 36 acotho. The roaaco for tasting thlo ago croup la that thla group ecncnly report* a higher percent*** of childhood p"*--la anay larg* cltlaa thaa doa* any other age group. The design of the study aaraly aavlalcoad a croaachaok of each of tht four test methods aod w not ecncaraod la thla jhaaa vlth shether or not tbs atfeyecta actually bad been polacoad. Using the blood load level as a standard, all other teste vara correlated vlth thla tact la aa attempt to determine relative significance of the other taata and relative accuracy of the reeult*. lb* upper Halt* of oormal for the four biochemical tests vers aa follow*) blood load, .06 mf./lDO pm. of blood) urlaa lead, .00 ag./l of urlaaj urinary ooproporphyrla, JO mlorogrea/lOO ml. of urln*) and urinary dolt*.aminolevulinic acid, 0.6 ng./lOO al. of urlaa. Sloe* thla study appaara to b* the moat rigidly controlled and mxtaoalva thus far reported, the reeult# obtained are of vary great laterest to our Industry area though the teat *\fc>ct* ear* not adult*. X nay aay bar*, parenthetically, that the reeult* recorded la this study parallel the** which vt find la the automobile laduetry and Indicate the reason for tha us* of tho blood lead datanslnatlca exclusively la this Industry. Xa brief, the atudy reeult* showed that neither tha urinary l#ed velus, the urinary coproporphyria or tha urinary deltaaminolevulinic acid value correlated vlth tha blood lead value, for example, h.ff of tha blood lead determIcet lone were positive, vhlle f.ff of the urinary lead determination* vara positive) however, tha positive Individual* did not oolncld*. Xa other  ~s . -Ji Vi uau) h t o ept c *ro s ayen tinxgn h o . m paga s. vorda, tboaa vbo wn poaltlvu for tba blood load aatbod wrt act tba mm u tboaa id)0 ra poaltlvu vlth tba urlaa load aatbod. Although tba pareantaga cf poaltlvaa rarlaa yltb tba aatbod balng eorralatad, tba raaulta of tba atudy aa fur aa tba otbar Uit aathoda ara acoeanad 1* tba aaaa la that tbara la practically oo oorralatloo. Aaoog tba Intartating ecocluaUoa xoacbad by tba autbora art tba following! Olio# tba taehnlgoaa bara aaployod, tba caooaotratleoa la a caaual urlaa apaclato of dalta-aalnnltvullnlc acid* laad, aad eoproporjfayrln eaoaot ba railad upoo for acroanlng purpoata to pradlet blood-laad ccoouctratlcoj Blood obtalaad by vunlpunetura la tba aa grcupa atudlad, tdiUa raijulrlng paracooal akillad la tba procadura, la a vortakla tachnlqua aad la aeoaptabla to tba groat ajorlty of paraataj C>a Obtaining of tba urlaa apaolatna la tbla group la difficult aad tba rallability of a alagla apaolaaa la dodbtful. Va tblak you *111 flad tbla to ba a aoat intaraatli* atudy aod auggaat that you obtain a copy of tba oa^lata papar from tba 0.8. Papallaiut of Baaltb, Iduoatloo aad Valfara, Public Baaltb Samoa, Dlvliloc of Aocldaot Pravantlon, Buraau of Btata 6arrleta, Voablagtca g}, P. C. Adk for tba July-Auguat 196} Bullatla of tba Batlobal Claarlagbouaa for Poltoo Costiol Cantora, aatltlad *Laad Folaoalag Scroaalng Taat Btudy". POP] ad v Pen 0. fowlar * J