Document EqBzr35D7mONVJmJ3G71KwRYb

MMeemmoo ATTACHMENT 8............"" hMaDtHa ToDaDtaete:: To: FFrroomm:: Subject: TTeno tedr AApprriill 44,, 22000077 Tim Scherkenbach MAMisinnsninseetsasoontttaaCPPooomllllmuuttiiisoosninoCCnoeonrnttrrooll AAggeennccyy IEiLmeSr ,HDaiDDiisss John Linc Stine, Division Director, > a .John Linel Siine, Di~6sion Director ~~ Environmental Health Division / ~/ ",_.~ " Minnesota Department of Health l./ ' Hazard Determination of PFOA and PFOS er ep ep, TThhiiss mmeemmoorraanndduumm iiss iinn rreessppoonnssee ttoo yyoouurr qquueessttiioonn rreeggaarrddiinngg tthhee ppootteennttiiaall ffoorr ppeerrfllluuoorrooooccttaannee sulfonate (PFOS) and perfluorooctanoic acid (PFOA) to pose a substantial present or potential.. hazard to human health. . ~ Trapper pgp fi MN rn or begets TsstthuueddiiMeessoinofnflelaasbobotoraraaDttooerrpyyaraatnnmiimemnaaltlssofaannHddetathhltaahtt (tthMheeDttooHxxi)icchiiattyys oodbbdssteeerrrmvveiedneiidnn ttthhhaeetssetehssettuucddhiieeemss iiicssarrlbeslleaevrveaannttotxttoio'c in h`huummaannss.. TThhee hheeaalltthh eeffffeecctt ffoouunndd iinn mmoonnkkeeyyss,, rraattss aanndd mmiiccee aatt tthhee lloowweesstt ddoosseess tthhaatt pprroodduuccee am, Tokiof fmfsmbes at anit te lot oes te toxicity was increased li;ver weight along.with clinical symptoms and histological evidence of liver toxicity (Butenoffet al. 2002; Sibinski 1987; Seacat et al., 2002; and otherpapers EkSESwt Wl 30 Fm Rl tis ddthooyccruuommideenhntoteerddmiionnn. ttehheeleaavttettlaascchahmmnedentan)ft.)f.ecAAtttdsseiivmmeiilllaoarprmddeoonssteessinoorranhhiiigmgahhleesrr ddeooxszpeeosssetthdheedssueerccihhneegmmgieiccsatalalsstiaaollnss0o(Saaelltateecrrat ct thyroid hormone levels and affect development in animals exposed during gestation (Sacat et aall..,, 22000022~; LLaauu eett aall,, 22000033 aanndd 22000066;; W Woloflf oetr aalt..,, 22000077,, TThhoommffoorrdd22000011)).. AAddddititiioonnaall eeffffeeccttss ooccccuurr at, higher levels: PFOA exposure to mice during gestation reduces pup survival and mammary ee en ly ht may ln `ggmlliaacnneddaddffeeevvceetllsootpphmmeeeinntmtm((uWWnhhieittseeyeestttaeallm..,,(22P00e00d77e;;nLL-aaAuudaeetmt saalte,,t22a00l.0,066;2;0W W0o6o)l.flfeTethtaeall..M,, 22D00H0077b))aaasnneddd PPthFFeOOrSSisekexxppoossuurree ttoo mice affects the immune system (Peden-Adams et al., 2006). The MDH based the risk a`asssseessssmmeenntt ffoorr tthheessee cchheemmiiccaallss pprriimmaarriillyy oonn tthhee rreessuullttssooff mmoonnkkeeyy ssttuuddiieess,, iinn ppaarrtt bbeeccaauussee)thhee chemicals' biological mechanisms in monkeys are likely to be most similar and relevant to huummanasn.s. RRaattss eexxppoosseedd ttoo hhiigghh lleevveellssooffeeiitthheerr cchheemmiiccaall ddeevveelloopp ttuummoorrss iinn tthhee lliivveerr-aanndd ootthheerr ssiitteess.. TThhee stm ose bums weet ttPurumemvooerrntssiiittoeenssooocfccctuuhrerisinen sttehhneesisstaaimvmeee, .oporrrgegacanunrsststhohraatetfaafrreeectttshheewimmlolospstrtossteeenncsstiitatiigvvaeeinttsoottththeheehhseeuaalbltsthheqeeuffeffenecctttsdsennvooettleeddopaambbeoonvvtee.. Prevention of these sensitive, precursor effects will protect against the subsequent development ooftfutummorosrs.. IInn aaddddiittiioonn,, hhuummaannssaarreennoottaasssesennsistitiivvee aass rraattss ttoo wwhhaatt iiss bbeelliieevveedd ttoo bbee.tthhee mmaajjoorr mechanism action for inducing liver tumors. Th"TuhhmeeaM MnDsDcHHomhhpaasasruuessdeeddtotthhaeentiotmoxaxilcisci,ittyyasntsdtuudsditieeassn.,d, aiirnndffoorrrimmskaatatiisoosnnesaasbbmooeuunttttthhpeeroaaccceccduuummrueulslaatttoiioodnneovofefeleoaapcchahriccohhreeammliiccaall iinn humans compared to animals~, and standard risk assessment procedures to.develol~ hti oral rreeffeerreennccee ddoossee ffoorr eeaacchh cchheemmicicaall.. mm On de re GT Environmental Health Division - 625 North Robert Street - St. Pau!, MN 55101 - (651) 201-4675 www.h~l~.state.mn.us Exhibit 2145 State of Minnesota v. 3M Co., Court File No. 27-CV-10-28862 2114455..000001 STATE_02338891 MMAprrr.~ilTTi4im,m2SS0c0h'7herekrke~nbbaacrhh APPaapggreiel ?4;-12007 2 .', ..... TTthhheeeprroeepffueelrraeetnniccoeen)ddootsoseedeiissvecclooommpbbHiiennaeelddtwwhiiBttahhsaaennd~aVppapplrruooepprsriifaaott.reedwwraiatnteekrriniignntawaakkteeer((,eennwcchooimmcphpaasasrsseiinndgges99c55rippbeeerrdcceeinnntttohoeff athtetapcohepdulmaetimoons).toTdheevvealolpue.sH(e0a.l5thuBg/asLefdorVPalFuOesAfoarnddr0i.n3kiungg/LwfaoterrP, FwOhSic)hraerepdresecsraibeleendvetilnatthe `tawwhththeaiiscccehhhfennidnoodmhihneeegamaslltotahhsr.eeeTfflffhieesecctttevssdattiloounehhtsuuhem(m0aaa.5ntntssuacgaahrr/Lemeeaanfnnotttsrii.ccPiiFppaOatteAedd..anTTdhhee0.ff3iinnuddgii/nnLggssfoaarnnPddFrrOeessSoo)uurrreccepessreuussseeenddt attooleddveeevvleelalootpp these fmdings are listed in the attachments. . : PrPFeFOcOSoSmhmhaeasnsdbbieeneegnn lffioomuuinntddiinignnmsseooammleseofffiiscshehrsstaaammipnpllefesiss..hTTihheeoMrMdDeDrHHtoiiksssesueueepddtffhiiesshhpcucboolnniscsu'usmmpeptxtipiooosnnuaarddevvi(i0cceePF OS _ fdrfrerooocsmmoemfffiomissrhhebPnbFdeOielnoSgwtlltoitmhhreeoei2te2i0vn0wa0g0l22umapptereraoolfvsviiiossshifiootcnnieaasrlltsarruiencfeoefnrieschnfencitneerdadootrosridseoeenr.e.,sTTt.OhhnTkeeheMecMeDpMDeHtDHhweHiwpliaullnlbutulisiscceei'tsptahheteexes2p2o0t0hs00au77tro.efrouarttOalulrPrreFeefffOieesrSrheennccee:. dccooonnsessuufmmoprptPtiiFooOnn Saaddtvvoiiccreeeewwviailllllubbaeteemmfoiosrhreetisssttsrriuinenggceeonntnt c((aaenllotorwawteeiror nPPsFF,OOTSShelleeMvveeDll Hiinnaffniibtshihcfifpiillalleteettsss wwihiilalltl fttruiitgguggreeerrfaaisddhvviiccee. ttoo lliimmiitt ccoonnssuummppttiioonn ooffisfihs)h.). PrPeFFsOuOlAtAs eaaxnncddePPeFdOeOdSShMhaDavveHebbegeueeindneffloiounuennsddoiirnn HdderraiinlntkkhiinnBggaw;sfafeatdteerVraiilnnuLLeasakkteehEeElMlmmDooaHanniddssOOuaeakdkddawaellleel.. aW Wdhvhieesnnorwwieeelslllthat rrrreeeecsccuooolmtmmsmmmeeeexnnncdddeeeeedddd,ettthdhhaaaMttt ttDthhheHeerrregeesussiiiiddddeeeennnlitttnsssessss,hhhoooouuruHllldddennuaosolttethdtartBnriiannaskklettdthehmeVeatawwilauavtteeesesrootohrureruucMsseeoeDfiidHtt rffoioisrrnskccuiooeonodkgkiwiwnneaggtl.l.erTaT.dhhveTeihsMMiosrDDiaeHHdsvithcea:t : hreacsoamlsmobeenednedsthhaartetdhewirtehsitdheenMtsinshnoesuoldtausPeolalnutailotenrCnoantitvreolsoAugrecnecoyfidnrionrkdienrg(w0 gauteird.eThis advice hiinnavvseeasstltsiigogaabttieioeon.nnaasnnhddarrreeedmmeweddiitiahattitihooenn,,MaaninnddntteoosopptrraoovPviioddleeluaatillottenermnCaatotiinvvteerowwlaaAtteegrrenssuucppypplilniieeossrdttooercciitttoiizzgeeunnissd..e IInn ssuummmmaarryy,, wwee bbeelliieevvee tthheessee ccoommppoouunnddss ppoossee aa ssuubbssttaannttiiaall Pprreesseenntt oorr ppootteennttiiaall hhaazzaarrdd ttoo hhuummaann ~hheaelatlthh.. AAttttaacchhmmPeenFntOtss:A: Health Based Value memo with attachment or PPPFFFOOOSSAHHHeeaealaltltthhh BBBaa~ssseeeddd VVVaaallluuu~ee mmmeeemmmooo wwwiititthhh aaatttttlaaaccchhhmmmeeennnttt ce: LPaammyShGuubsta,t,MMDDHH. . RRPi:iattmaa M.MSelesmsssbiianntgg,,,MMMDDDHHH . PDPaaouuullgHHoWofefftf,z,sMMtePPiCnC,AAMPCA Doug Wetzstein, MPcA 22114455..00000022 SSTTAATTEE__0022333388889922 EE MMeemmoo a DaDtaete:: FFeebbrruuaarryy2266;~ 22000077 TToo:~ Via: John Stine, Environmental Health Division Director Ms John Larry SGtuisnte,, EEnavviirronomemeenntatll.HSeaulthrDivviseionai..nDdlAirseesctsnosrmc~e~net"2S~e!c/tli|to~n~ Ma na. ger /~ ns p,i,Jersa / Via: Pamela Shobah, Heh Risk Larry Gust, Enviror~emental Pamela Shubat, Health Risk Assessment Surveillance Assessment Unit Supervisory grotoh antiAssessment Sec]tion Manager~ Unit Supervis6r!~g,,tM- - +Lg/h3/Z~t. "{, ~ . From: HHeelleenn GGooeeddeenn,, HHeeaalltthh RRiisskk AAsssseessssmmeenntt UUnniA itt ssttl aaffff MJut,7 l'~v . " " ~ SSuubbljeecctt::. HHeeaalltthh BBaasseedd VVaalluueess ffoorr PPeerrfflluuoorrooooccttaannee SSuullffoonnaattee ((PPFROOSS))-- .- In 202 he Mists DepttofHeth UDB) developed a HIV of 1 po PRS. Sic 2002 In 2002 the Minnesota D~partment.ofHealth (MDH) developed a HBV of 1 ppb for PFOS. Since 2002 tart ot mimo ee ors i rs additional toxicity data, toxicokinetic data, and reviews of preexisting datahave been produced. After a a es careful review of.this information the Health Risk AssessmentUnit staff recommends that the HBV for es PFOS be lowered to 0.3 ug/L (ppb). TS SL EY The follgwing information was utilized in generating the revised HBV: CChheemmiiccaall ~~ CCAASSH# Tr PPFFOOSS 11776633--2233--11 Endpoint Endpoint hheeppaattiicc ((lliivveerr)) ssyysstteemm and thyroid RO~ (Dmgfked) HHBI~YV((uu~gJ/Ll)) SSoouurrccee 00..000000007755 00.33 `M MDDHH22000077 ia forging degen 0 EN, Apt, Eas hed More detailed information, supporting the development of the HBV, is attached. Please be advised that; eo msioto lov prep ts vss although _we believe that this number willproVide an adequate level of protection, thereis a degree .of u`unncceerrttaaiinnttyy aassssoocciiaatteedd wwiitthh aallll HHBBVVss,, aanndd tthheeyy sshhoouulldd bbee ccoonnssiiddeerreedd pprioovviissiioonnaall.. PPrrooffeessssiioonnaall jjuuddggmmeenntt a an mbt Sa wi sm ie shouldbe used in implementing this HBV. MDH will review this/-IBV if and when additionhl studies He have been conducted. TThhee RMDIDHH's's aafiitthhoorritiyttooy pprroommuullggaattee hheeaalltthh rriisskk lliimmiittssuunnddeerrtthheeGCrrorouunnddwwaatteer~PProrotteeccttiioonn AAcctt iiss lliimmiitteedd a pe to situations Where degradationhas already occurred. Similarly, health-based values, Which are unAA OT promulgated exposure values, serve as interim advice issued for speeifio .sites where a contaminant has bbeeeenn ~ detecte.d. AAssssuucchh,,nneeiitthheerrhheeaalltthhrriisskklliimmiittssnnoorrhheeaalltthh--bbaasseeddvvaalluueessamr-eeddeevveel]ooppeeddffoorrtthheeppu.~rmppoossee rim vo pn. of providing an upper limit for degradation. = roapne , Pa.m. Shubat, IVIDH ont Rita Messing. MDH en Cathy Vitlas-Homs, MDA Ee . Shvlley Bunnan, MPCA ms Paul Heft, MPCA EE Doug Wctzstein, lvlI~.CA~ foe aR AaC a r I EA HE ry Environmental Health Division 625 N. Robert SL, P.O. Box 64975, St. Pau.I, M'N, 55164-1D75 - (65~) 201-4899 hnF~/wwwa~lth,stat~,ran,us 22114455..00000033 STATE_02338893 : (CoAArrTTecTTteAAd CMCaHHrM cMhEE9,NN2TT007) (Corrected March 9, 2007) DDAATTAA FFOORR DDEERRIIVVAATTIIOONN OOFF GGRROOUUNNDD WWAATTEERR HHEEAALLTTHH BBAASSEEDD VVAALLUUEE ((HHBBVV)) CCChAheSem:micic1aa7ll6NN3a-a2mm3ee1:: (PPaecerirdff)lluuoo~p'ooooccttaanneeSSuullffoonnaattee ((PPFOOSS)) - CAS: 102279296020385~81-21-13554-616--989(a(((cadaimdime)mmt-ohoannniioualmmamssiaanllett))"salt) 70225-14-8 (diethanolamine salt) 222707949555-7-33.997-2-33.5((pp(oloittatahsssisiuiumummsasslaatlltt)) 29457-72-5 (lithium salt) NNoonn--CCaanncceerr HHeeaalltthh BBaasseedd VVaalluuee ((HHBBVV)) ==003.3ugulgl/L. = = Goxiity (toxicity value, value, me/ke/d) mg/k~d) x X (relative (relative ssoouurrccee ccoonnttrriibbuutitioonn)) x x (1(0100000 uuggi/tmngg)) - ((iinn.ttaakkee rraatee,, LLi/kkgg--d)) =((00..000000007755mmg(0/g.k/0gk4/~8ddL))ixxg/((d00i,22y)))xx((1!00000vu/~ms_)~) (0.048 L/kg/day) = 03ugL TTooxxiicciittyy vvaalluuee:: 00..000000007755 mmgg/!kkgg--dd ((CCyynnoommoollgguuss mmoonnkkeeyyss)) Sourceof toxicity value: MDH 2007 (RID derived by MDH) Source oftoxicity value: PPooiinnttooffDDepeaPratruturree:: -. Dose Metric Adjusiment: 20 (0 adjust fo haf duration of 5.4 years in humans versus 110 - Dose Metric Adjustment: `TToottaall uunncceerrttaaiinnttyy ffaaccttoorr:: UUFF aallllooccaattiioonn:: MDH 2007 (RfD derived by MDH) `mmiinniimmaall LLOOAAEELL,, 00..1155 mmgg/ikkgg--dd 20 (to adjust for half-life duration of 5,4 years in humans versus I 10 -. 1133'22 ddaayyss.iinn C,,Cynyonommologlguuss mmoon~knekyeyss)) 110000 33 iinntteerrssppeecciieess ttooxxiiccooddyynnaammiicc ddiiffffeerreenncceess,, 1I00 inntrraassppeecieess vvaarriiaabbiilliityy; aanndd 33 LLOOAAEELL--tto0.--NNOOAAEELL ((aa vvaalluuee ooff33 wwaass aapppplliieedd ttoo tthhee ssttuuddyy LOAEL rather than using the NOAEL or the default UF of 10 because LOAELrather than using the NOAEL or the default LIF of i0 because'- the eect observeda the LOAEL was considered to be ofminimal the effect observed at the LOAEL was considered to be oftninimal severity) -CCrriittii~c:aall effect(s)*: CCoo-c-cririttiiccaall eeffffeecctt((ss))**:: AAddddititiivviittyy eenaddppooiinn(ts()s:): SSeeccoonnddaarryy eeffffeecctt((~s))**:: severi~) .. DDeeccrreeaasseedd.HHDDLL aanndd TT33 NNoonnee HHDeeepvpaeatltioiccp(m(liieivnveterar))l.ssy(ydssettecemrme,,asTTehhdyyrbroooiidddy(wEEe))ight/weight gain, decreased total Developmental (decreased body weight/weight.gain, decreased total T4), decreased gestation length, immunc system alterations T4), decreased gestation length, immune system alterations Cr opto ar ems ae Glos loosed a * for explanation of terms see Glossary located at:. httl~://~avw,health.state.m n.u s!divs/ekZ~.round water/hrl _~w/glossary.h tmi CCaanncceerr HHeeaalltthh RRiisskk LLiimmiitt ((HRRLL)) == NN//AA VVoolalattiillee:: NNoo : AAdttaacchhmmeenntt PPaaggee 1!ooff 7~ 22114455..00000044 STATE_02338894 STATE_02338894 ,`TSoSuxumimcmmitaayrryVyaoolffucechh(aaRnnIgDge)es:s S~iinnccee 22000022 HHBBVV:: mThIemnotppxrrriicoocivvtayeedddjVuttaosolxtxuiimecceoo(nkERtiifnnbDeeat)tsii:ecd((eo5.ng,.h,ahhlaalffl-lefifed)i)fiifnneffrooerrnmmcasatstiibooenntaawllelloeownweehddumffooarrntsthheaeniidnnccmooorrppnookrreaayttisioonnaon0dffaaa 212000---fffoolllddddddeoocssreee--ase in t1tmh0heeeatdttroiodcttraaeallsdUUsjuFFus.n.tcmIIennret22na00ti00nb22taiseaaesd33a00or--noffouohnlddadlffft-aaolccixfttieoocrrodk((ii33fnfeeiilnrniettcensrr.csseppese.ccbiiecetssweeexxettnrraahppuoolmlaaattiinoosnna++nd1! 00mssouunbbkcchehyrrosonaniniccd--otao--c1ch0hr-rofoonnlidiccd)) ewwcaraessauusseseeiddn. to address uncertainties around toxicokinetics. IIPnnOttaaSkk,ee rauatntele.i:ke mos ground water contaminan,ts, has long hall:1if and therefore will accumalate inthe PbPbooFFddOOyySSii,ffwuirrlneelpplieerkaaeettaeemcddho,easextxpppgloorasostuuuerarneeudoo(wcsctccaeuutaredrssyr-coosotvvaenetrtrea)mll.ooinnnTg:a-hpnpeetersr,liioohdedasssonoafofglfiotinmttmigeemh.he. aEEtlvvfoeqenrintfeteuauacaalhlnli~dsyetttahhhdeeyriiennfsttoteearrrtenneaawclloicclnloodnanicctcecienuontnmtrsraauittlsiiaootnen ooinffthe + eaePqqpFupuOirivvoSaxalwileemninalttlttetroeolayaacpp2hpp7ryarooepxxaliiarmmtsaeata(teue5lly(xysht55euahhmdaaayllf-n-svltiheavtseeas.)..lTIIfnnhtteohh'feele5cc.naa4gsstyeeheoaoorffsf)Pt.PiFFmOTOSehSetotthihrneeetaitacikmmheeesrtattetooaedssstiyeeclaaseddtcayytt--eessdttcaafottoneerdwwtihotoieuoulrnleddsvbibisseeed HBV. 4waw)pa.apssrToahxiitiimsmmei-aent-wtewealyikeeigg2hah7itteeyddeianaarcvsvoee(rrr5paaagxgreeahtiiuennmsttaaatkknheeehoohaffilgafah-nnleirfuueppipp0ne.tefrar5--ke.ee4nnod.dytecceaoornnsc)ssa.uurTmlmyheeerirnioonivvteearrkeetthh.reeatffeiiirrnsssfetal22ne77tcstyyeaedenaadfrrosscroohtfifhlelfdifrreeeenv(()0i0s..ae00sd44w88HelLLBl/kkVaggs-=. ttdhh)e.e accumulationofthe chemical ove tne. This intake rate incorporates the higher intake accumulation of the chemical over time. rates early in life (i.e., infants and : children) as well as ``CGCorononwssitiddheedrreaafttiiicooinnto,ofafleSeaeranstsiiittoinvvseeiPPnootpphuyulrlaoatitidioohnnoss:r:mone levels (T4 and T3), increased fiver weights, and delays Gioinnbisoddeewervvvteehelldodopepaffmmiecdcnionttsste,hhsaaalsvvtpeeeprabbrteoeiexeoninnmsrraeeilnppeooltrhyrtty3eerddotiioindn7oohtffoiffrsmsmpperrosiinnnheggigleeehxxvepperoolsstseeh(ddTa4ddtuuahrrneiidnniggTcdd3aee)vilv.eeinllsocotprpuemdmayesenenm.dti:n]iiTTvmhheaerelssweeLeOeeigfAefhEcetLctst,.ssawwnPedoertrdeeenetlaiayls ohHscbeceasanelltarhfrv-ibeboadasssaweetddedrvovaaseleluvuseaealsspubbapaatrsesoedex:ddimo1oannteppllrryooo.tnt3eegcctteotiiroo7mnntioomeffaeaxspphrrpieegghgonea--aynsnettthxuwwapnoorammthateaenncaar(in0ntdidtchahheleermrstoffuteedthtuyuessrmwwfieenrrroiememeeabvvliaaLltluhOuaattAtoeedEda.L.g.eTTPww2o7ooteynetairasl, a nasacncdedcn2u2am))ruilaaoasssthwihooeronrt-erotteeevtrrvem.maliueemaxtpexeodasp:nud1roe)u--a-tsileeloixxunzppgeoord-stsaueuerrrtmeeimtteoeo~-paawnoesiiiUgnnhrffeaatnne-ttd..eTixTnhphteeoakslleuoornaengtgt-c-otet0treh.mm0e4eem8xxoppLot/ohskseugurr:re.efrosscmcTeehnnbeaairrrsiitohhootiironntcc-aootgrreeppmoo2rre7aaxttypeeeoddasrusr,e asLscicckeecgnnu-aamdrr.iiuoolTaddhtiiiedodnrnneooosttvuleiintrnicctnooigmrrpppeooortaraeantntdeteiuaaaltccicclHiuuzBmmeuVdulslaaatttfiiiooomrnneboo-owvvteheerrisgtcihiemmtneeaedrbibiuountsttawddkiiredderuuatttinielloiitz0zee.l0aao48wyyooeLuu(/nnk.ggg.-iidnnm.ffoaaTnnrthteeiinrnsetthasatkokrereitc-rrttaeiatvreeem)ootfefhx0ap.n02o.22ts2h11uere HBY based L/kg-d. The HBV based oorennstuthhleteinesgelleepccottteeeddntccirraiilttiiHccaaBll Vssttsuudfdoyyr in monkeys. both scenarios in monkeys. were not lower (i.e., more restrictive) than the SSuummmamrya~ ooff ttooxxiciictyit~ tteessttiinngg ffoorr hheeaalltthh eeffffeeccttss iiddeennttiiffiieedd iinn tthhee HH~aalltthh SSttaannddaarrddss sSttaattuuttee:: [--Tes_ted_? TEEndSnoeccri.dne _o[icmImmurmnuoYntieootsxoixncieiitteyy|DDeve eYloepsmvent e|RRl eepprYorodo eduucscttip ivvee |mNNeuee ruorotYotn onexisciciitt t~y | Tested? : OObbsseerrSvveaaett.iioonnss~! Yes Yes Yes' iYes- Effects? Yes Yes~ Yes3 Yes4 ........ Ye~~ Note: Even Teg or pci hel Geta mo ondacd For his heme, oration S50 ar etm be Note: Even ift,esting for a specific health effect was not conducted for this chemical, information aboul that effect may be vale fom icsconde froepurpose Mostchemicals have een Sc uple suies fn which available from studies conducted for other purposes. Most chemicals have been subject to multiplestudies in which scares niyo doe wher bo efecs were dhsrvd, nd lowest dese acased an mere fc. xc researchers identify a dose where no effects were observed, and the lowest dose that caused ohe or more effects, A toxicity used on he fcahtoved 1 kdos srs al vb sis Cmdr preci ofl ier fects ~alue based on the effect obs~erved at the lowest dose across all available studies is considered protective of all other effects toca at iheds that occur at higher doses. CC"Toohmmymrmeoinedntlhssooornnmoeenxxattleennptterootffurttebesastttiiinonggnsoorrhaeevfffefeeccbttesse::n observed in laboratory animals at dose levels similar (0 the cr2~SrTihitohiircyctarlol-itssdetturuhddmoyyrimLLmoOmOnuAAanEEloLfpL.oe.xrtiAAulirltbtteeayrrtaaistottiinouodsnn,issehsiiannvhettahhvbyyererooesinihddoohhbwoosrremtrmhvooaetnndeePiFnlleeOvvlaSeebllsseoxrhhapaatovvoseeruyrbbeaeeneeainnlmteiiadrdlseesnnstateiitvffeidiereodadl~aassilemrcvmrieiutlinascoalslliomeegffififleaeccrct.tt.o'the KipzplaaSlrrheaaormmrcetet-etteelerrrssmac((tssiiumuvppimtppyrru)eenssatossiitolooennxvieooclfifstySSbRResBtlBuCo-dCwsit-epshsepecheicarfivifieiicccsahl1lgo9MwsMtnuppdrrthyooaddLutuOccPtAtFiioEoOnnLS.aaennxTddphTTeose-bculierolelll oappglrrtioeoclrlaisilffeessrreiaavgtteniiorioannfl,i,ciiiamnnncccmrreoeeuaafnssoteehlddoegnnsaiaectteuufrrfaaellcts killer cell activity) at levels below the critical study LOAEL. The biological significance ofthe~e effects Attachment Attachment Page Page 2 2 ooff77 22114455..00000055 STATE_02338895 STATE_02338895 hiissu.nnmooattneesnntatiirrsaeellyyreccsllueelaatrr.o. faFFluutrrettrhhadtrrisostntusuddiyyn iiissmnnmceueedndeeeddfttuooncddteeittoeenr,rmmhiionnweeewvwehhree,tthhtechrrePPMFFDOOHSS ppwoiolssleessinppcoolttueendntetiiaiallmhmheeuaanlletthhsrryiisssktkessmtt9oas a3ahLsusoemecwcaooennnrsddaabarsoryydae'yefrffewfeseecuictlgtthaaottttfthiahnilistsoetfrtifiamsmtpieoer.i.nnsg in immune , decreased function, however, the'MDH T4, increased steal defects will and include decreas immune system as ed gestation length 3haLvoewbeerebnordeypowrteeigdhattilneoveflfssparpinpgro, xdiemcarteealseyd3-Tf4o,ldinhcirgehaesredthsatnertnhael cdreitfieccatlssatnuddydeLcOrAeaFsLe.d gTehsetsaetioefnfelecntsgth hahhdaaadvvvieeetibbboeeeneeeanlnn driideedpeevnnoettrliitoffeiipdeemddeantaatttlea~svlceeccel.gsf0nfnaeddpcaatprrsryyo(eexdff!effmceerccatettsase..slyeAAdt3tp-ddfuooopssldeevssihaaaibgppilphpirertoqryx,xtihidmmaeanvatetteehllleoyypcm11re0i0t-n-iftfcooaalllldd~dhhteuiilgdgahhyyees~Lr)OttahhrAaaennEoLttbhhs.eeeTrLLvheOOedsA.AeEEeLLffects " "A male reproductive study reported decreases in sperm count and increases in sperm deformities additional developmental-effects (decreased pup viability, developmental delays) are observed: 4 A male reproductive study reported decreases in sperm count and increases in sperm deformities aatt *lleeHvvyeepllossa11c00t--iffvooellddrhheisiggphhoeenrrsettshhaatnno itthhceeacclrriiittniicchaalalsssttbuueddeyynLLoOObsAAeEErLvL.e.d in neonatal mice acutely exposed to levels 75-fold h~ iHgyheproatchtainvethreescpriotnicsaelsstOtundyicLotOinAeEhLasbbuetetnheosbeseefrfveecdtsinwenreeonnaottalobmsiecreveadcuatteleyveelxspo5s-efodldtohliegvheelr/.; 75-foid e`ChCxiogopnnhovvesuurelldtsshiitaooonnnsslt,,ehvsseeeelcvvsreeiartrpieecprrariilogg'sxiitddiuiimdttayyytaeaLnlnOydd Ab3b0ooE-ddfLyyoblttudrreteh.mtmihbgbelhlsiienenrggetfhhhfaaaenvvceettsbbhweeceeernnrietoocnbbaosslteesrrovtvbueesdddeyriivnLneORdRAhhaeEetssLluue.ssvemmloson5nk-kfeeoyylsds sshuuigbbchchehrrr.oonniiccaallllyy - exposed to levels approximately 30-fold higher than the critical stu.dy LOAEL. AAttatacchhemmeenntt PPaaggee 33 ooff77 . 22114455..00000066 SSTTAATTEE__0022333388889966 TThhee ffoollloowwiinngg ssoouurrcceess wweerree rreevviieewweedd iinn tthhee pprreeppaarraattiioonnooff tthhee HHBBVV:: AAPennrddfeelrrussoeernno,,aMMkyEEl,a,cecitt.d. saalli..,n 22M00o00n66kPPehhayarr~smmaaPccroookbkiininnegcttiitccheMMoDoeddteeelrliimnniggnoaofnftSSsaatotuufrraLabbollneeg,, RRPelenanasalml aRReHesasolorfrp-ptLtiiioovnnesoo.ffToxicology ((Pooennr-fllliuinoner))oddaoolkii:y:11la00c..1i1d00s1166in/03.Mt1o0xox~n.2k200e00y66s.~-0088P..r00o00b44ing the Determinants of Long Plasma tlalFLives. Tqxicology AA1u1us1st0tii1nn2)ee1tt4aa8ll.5,,-NN1e4eu8ur9ro,oee2nn0dd0oo3ccrriinnee EEffffeeccttssooffPPerrfflluuoo~r:ooooccttaannee SSuullffoonnaattee iinn RRaatsts.. EEnnvv HHeeaalltthh PPeerrssppeecctt 1 i 1(12)1485-1489, 200.3 BIBomanmndudyynoGGm,,oI1dCCuulurtrrriaaonn,n, bLLyCCpoeoaradfdyly,u,oCCroAAorcrtmmasnsiterrsoounnligf,,onMMatPPeaa(rrePennFttOceSaav)u,,iVVn aLLi2is8stt-oodnna,,yLLraHHifieerelcidhiyrn,gJJlsSSthiuhedeynyn.ttooT,nnh.e TTIomoxxmiiccuoolnlooogmgisiostdt,,uAAlabbtsistotrnraaccbtty##p11e00r11f,l,u22o00r0o066o..ctanesul~fonate (PFOS) in a 28-day rat feeding . study. The SBBtuuetteecpnnhDhooosffef-eftReeatsall,,pPoPneesrrffell.uuoorTroohooeccttTaaonnxecicSSouullloffgooinnsaattte6e~6-(IIn1n)dd:uucc2ee5dd(PPAebersritinnraaatctaatliM1M2oo0rr)tt,aall2ii0tt0yy2..iinn RRaatt PPuuppss iiss AAssssoocciiaatteedd wwiitthh aa Steep Dose-Response..The Toxicologist'66(i): 25 (Abstract 120), 2002. (BBPuuFttOeeSn)nh.hooTfffhefet eaTtalol,,iTTchohylyrorogoiiiddsthh,ooArrbmmsootnrnaeecssttaa#tt1uu7ss4i0inn,aa2dd0uu0l5ltt, ffeemmaallee rraattss aaftfertaanneoorrraall ddoosseeooffppeefrlfuluoorrooccttaanncessuullft~onoantaete: (PFOS!.The Toxicologist, Abstract #1740, 2005.. ~ TCCouuxrrirrcaaonnloeegttiaasllt.,, APPbeesrrtffrilauucootrroo#oo1cc0tt2aa,nnce2ss0uu0ll6ffoonnaattee ((PPFFDOSS)) TTooxxiicciittyy iinntthhee RRaatt:: AA 2288.--DDaayy FFeeeeddiinngg SSttuuddyy.. TThhee Toxicologist Abstract # 102, 2006 FfFuaannnctYYiOOo,n,oJJfiinnmYYalIHe,,rMMatasa]YYAXXr,t, iZZchhlaaenniggn YYChHHin22e00s00e55.].W[[eEEfifffeeScchttessnoogffYppaeernlfllJuuuoo.rrooJoaocnct;ta3an4ne(1~s)u:ul3lff7oo-n9na.attceacoocnnesssppsceerrdmmiaitoo:ggeennecssiiss hfh1uit5tntp8cp:6t/ii2/oww0nw1ww8owv)fnm.ncacbbliqi..nlralmmt.s].nnii[hhA.ggrtooivvcil/eeennittnrreeCzzh/qqiunueeer~ryey.],efWgcigeTii?ecSmmhde=dnR=geRtYertairnieevJveieud&.dJdbab=n=p;u3pb4um(bIem)d:3ed7dd~&o9pd.to=(paAtcb=csAetsbrssaetdcratac&tt:l&islitst__uuiiddss== 15862018 ) FFEnoovooiddroSSnttmaaennnddtaa.rrddssSeAAcggoeennndccyyD,,raCCfootmmWmomirtiikttcieenegoonnPaTTpooexxriicocinittyytohofefTCCohlheeemrmiacbicalaellssDaiininlFFyooIoonddt;;akCCeoonfnossruuPmmeeerrrflPPurrooorddouuoccctttssanaaenndSduttlhhfeeonate ((EMMnavayiyro22n00m0066e))n..t. Second Draft Working Paper on the Toierable Daily Intake for Pe~fluoro0ctane Sulfonate FiFnoooFooddoSSdt,taaCnndodaanrrsddussmA,e~grgeePnnrcco~yd, u((caatUUsnnaiinitbdeddthKKeiiEnnnggvddioormomnGGmoeovnvtee.rrnnmMmieennnutttAeAsgogeenfnctcyhy)e),, JCCuolomymmm1i1t,ittt2ee0d0o6onnmTeTeootxxiiniccgii.ttyyooff CChheemmicicaallss. in Food, Consumer Products and the Environment. Minutes of the July 11, 2006 meeting. thFFeooooEddnvSSittaranonddnaamrreddnsst.AAggeCennOccTYy,,,SCCtooammtmemimitteteoeneentootnnhTeTooTxoxilicceirittayybl((eCCODOaTTi))loybffICCnthhaeekmmeificcoarallPsseriinnflFFuooooorddo,o,cCCtooannnsesuuSmmuelefrronPParrtooedduuccttss aanndd . t((hNNeoo.Evveenmmvbibreoernrm2200e00n66t).).: COT Statement on the Tolerable Daily Intake for Perfluorooctane Sulfonate : FtFouuxeeinncttoeelssogSSy,,:MMcToTncCCuoorllrooemmnitinneaa,, JxRRoodpdrdtioggouupeeezzsr,,luPPouVVrioicocrecenntsase,,nJJeLLsuDDloofmominnaingtgeoo.(.PIIFnnOtteSerr)aaccattniiodonnssstiiennssddeeivvneeplloroeppgmmneaennntttaalmlice, TTtoooxxxiiciccooolollogoggyyy: Letters 164:81-89, 2006. concurrent exposure to perfluorooctane Letters ! 64:8 i -89, 2006. sulfonate (PFOS) and stress in pregnant mice. G`GweeartrmemraawnnitMMhinitnihisesttgrruyyioodfef HHseueabalslttthhanDDcreriisnnpkkeiinrnfggluWWoaratoteoercrtCCaonomommiicmsaisscisioidon(n..PPFPrOrooAvv)iisasiinoodnnaalpl eeervvfaallluuuoaarttoiiooocnntoaofnfePPsFFuTTlf-iionnnaddtrreiinn(kkPiiFnnOggS) daawssraieetexxnraakmmwiplipntehlgse-.sth.weJJauupgtlluyeyaird1l1e33,,s22u000b06s6.t.anhhctttepps://p//wesrwfwluwwo.ruuommowwcetleatlntbobuiucnndadecesisdaamm(PttFd.deOefA/uub)baaa--niindnfpfooe--rppflrrueeosssrsoee-o-ec/tihaninnt.teeerrsggurrluufnondnd/a/pptfef-t(-iPinnF--OS) drinking-water.pall .~. Aachen Atta'~hmeni PPaaggee 44 ooff77 22114455..00000077 SSTTAATTEE__0022333388889977 G(GrPraRasOsttSyy)eeitanlalt,,hCCerriRitattii.ccaaTllhPPeeerrTiioooxddicffooolrroIIgnniccsrrteeaa6s6s(ee1dd):NNee2oo5nna(atAtaablsltMMroaroctrtatal1li1itt8yy),IIn2nd0d0uu2cc.eedd bbyy PPeerrfflluvoorrooooccttaannee SSuullffoonnaattee (PFOS) in the Rat. The Toxicologist 66(1): 25 (Abstract t 18), 2002. "Toxicologist, Absract# 1916, 2000. GGrraassttyy eettaal!.,, PPeerrfflluuoorrooooccttaannce SSuuliffoonnaattee ((PPFOOSS))AAltlteerrss'LLuunngg DDeevveelJooppmmeenntt iinn tthhee NNeeoonnaattaall RRaat.t. TThhee Toxicologist, Abstract # 19,1'6, 2004 mHHeitimWWbreeannnyyeuueper,,oPPpeDDr..tiJJeOosnnecesas,,usWfefdDDbeeyCCopoceenrnf,,lLLorKKiininangtg,e,dPPcFFormraapkkoeeurrn,,dJ1sNN.eewCwsosmttpeeaddraaanntddivJJePPBGGiiioeecsshyyem22i00s00t33r..yAA&lltteePrrhaayttsiioiononssloiignnycceellll PanC 135:77:88. membrane properties.caused ~Part C 135:77-88o by perfluorinated compounds. Comparative Biochemistry & Physiology sHHueunWWeeexnnpryyeuusees,,ioPPnDD.p.rJJofooinnleeisns,g,.TTECCnaovliiitruuossnaamnneddntJJaPPlGGTioieexssiyyco22l00o00g55y.. aIIndddeennPtthiifafiirccmaaatticiooonnlooofgfgygeeJnnaeenss(rrVeeasslppoo1nn9ss,iivvseeutteoo PP1)FF: OO5SS7-uu70ssi,inngg~" gene expression profiling. Environmental Toxicology and Pharmacology Jan (Vol 19, Issue 1): 57-70. JpJoeorhhfaalnnussossrooonno,,ctNNa,,noeeittcaala,.c, i22d0000(66P..FNNOeAeoo)nnacatataualsleeesxxppdoeosrsuuarnreeget(od0 bppeeehrrfafivluiuooorurorooocactnaidfiieeinsscuurlleffaoosnneaadtteesu((sPPcFeFpOOtSiSb))ilaainntddy of the Cholinergic sysem in adult mice. The Toxicologist Abstact# 1458 perfluorooctanoic acid (PFOA) causes deranged behaviour and increased cholinergic system in adult mice. The Toxicologist Abstract ~ 1458 susceptibility of the KiKemeimillunDDoEEl,o, gTTiMcMeahlelhflmmuanacnnt,i,oLLn BBinuutFttt1eerrmwwioocrertt.hh,,ThMMeMMToPPxeeiddceeonnl--oAAgdsdatammAsb.ss.tGGreaescstttaat#tii8oo8nn2aa,ll2ee0xx0pp5ao:ssuurree t(o0 PPFFOOSS ssuupppprreesssseess immunological function in FI mice. The .Toxicologist Abstract #882, 2005: LLPoaasuut,,naeetttaaalll.,E,v22a00l00u33a.t.iEEoxxnpspo.osTsuuorrxee SttocoiPP1ee4rr:ffllu3u8oo2rr.oo3oo9cc2tt.aannee SSuullffoonnaattee ddourriinngg PPrreeggnnaannccyy! iinn RRaatt aanndd MMo;ouussee,. IIlI.. Postnatal Evaluatioris. Tox Set 74: 382-392. LPLaahuua,, metatl 1a9i.:, 2220300104-4.2.4TT1hhee ddeevveellooppmmeen.nttaall otoxxiiccittyyooffppeerrfflluoorrooaallkkyyll,aacciiddss aanndd tthheeiirr ddeerriivvaattiivveess.. TTooxx AAppppll. Pharm 198:231-241. LALbaasuutrteatlcat,l,#2250070606.6.. EEvvaalluuaattiioonn ooff"PPeefrlfuluoorrooooccttaannce SSuullffoonnaattee ((PPFFOOSS)) iinn RRaatt BBrraaiinn,. TThhee TTooxxiiccoollooggiisst Abstract #576. LLSeiireeiddeeesrroPPfHHP,,ePPrfEEloNNrooikkneaertr,,edGGSASlGGkoyolrrmmCaaanrn,b,oSSxCyClaTTtaaennaaakknaad,, SJJuLLlfBBouuntateetnnehhsoof(ffCf.4.,2200C00666.a. nEEdfliiCmm8ii)nnaaittniiooMnnalPPehhaaarrnmmdaacFcoeokmkianinleetetiiccss ooffaa CNCSeyeytnrnhioeeormsmlooaolnflgdgPsuu.essrfMMluooonkrnieknyeasyte.sd. Poster A!k)~! Poster presentation Carboxylate presentation a the 2006 European SETAC meeting in Den Hoge, and Sulfonates (C4, C6 and C8) in Male and Female at ihe 2006 European SETAC meeting in Den Hague,. Netherlands.. LpLeoorggfaalnnuoMMroNNo,c,tJJaRRneTTshhuiilbbfoooddneaeataeuusx(,,PRRFOGGS)HHaoannnssotohnny,,roMMidSShttrroyyrnnmaaror,,neAAsLLtiaitnnuddsssttirrnooammd,u,ClCt aLLanaudu..n22e0o00n04a4.t.alEEffrffaeetccst.tssToohffe Toxiclogist Abstract #1917 perfluord0ctane Sulfonate Abstract # 1917 (PFOS) onthyroid hormone status in adult and neonatal rats. The ToxicOlogist (LLuuPeeRbbkOkeerSri,,)nDDr..atetsta.Talol,.x, iTTcwwoolo-o-gggeenync2er1ra5at:tii1oo2nn6-rre1p4er8o,pdu2r0c0ti5oo5~.daannuddcccrrotosss-sif-toobssttenerr ssttuuddiieessooffppeerrfflluuoorroooocctt,qinneessuullff0onnaa.tt.ee (PFOS) in rats. Toxicology 215:126-148, 2005a. `LLSupue_rbeabkgkeuerer,D, aDD.w,lteetayall..f,aNNtse:eooDnnaoatstaaellrmmeosorpraotlanilsitetyy, fafrnrodommbiiinnocuuhtteeemrroioceeaxxlppaoanssduurprehtatoormppaeecrroffllkuui0onrreoot0oicccttaapnnacersasumuelltffoeornnsaa.tteeT((oPPxFFiOcOoSSl))ogiinny 215:149-169, 20030. Sprague-Dawley rats: 215:149-169, 2005b. D0~e-response, ~ .and biochemical and pharmacokinetic parameters. -' Toxicology KEKxaaprrmoms~auarnneoAA,f, PIeEErrfriilccussooornno,,iBBnatvveaadnnCBBhaaevvmeeill,c,aPPlOOsDtDahmarmeouregurhuddL,,ocMMatAAiuounnne-~eAA,LevGGelllyysnnonnf,, SMSaLLtiicgghnnceeldlllHaaonndmGadGnLLMiiinndldsksttrraoonmmd..S22e0r00u06m6... = and a Temporal Trend, 1996 -- 2004, in Exposure ofPerfluoroinatedChemicais and a Temporal Trend, 1996 - 2004, in Sweden. through Sweden. EHP Online November 2006 Lactation - Levels of Matched EHP Online November 2006. Human Milk and Serum AAttliacchhmmeenntt PPaaggee S5"ooff77 22114455..00000088 STATE_02338898 STATE_02338898 caMMnaarcraeasrs,,ceMMlleetptarlao,l.f,2f02c00a06ti6.o.nEE.tstrEron0gygeeHnnI--lihikkPeeepprrrsoopppeeesrrtt1ii1ee4ss(oo1f)f:ff1lu0uo0o-rr1oo0tt5ee.ll~ommeerr aallccoohhoollssaas rreevveeaalleedd bbyy MMCCFF--77 bbrreeaasstt cancer cell proliferation. Env Hlth Perspec 114( i): 100-105. OOpellrssfeelnnoeerttoahalle,,x22a00n00c55suEElvfvaoalnluuaatatetiio(onnPooFffEtt)hheeahhnaadllfpF-eilirfffeel((ut1ol//r22o))o"cooftfa~inlmoimsienian(taPtiFiooOnnAo)offpfperesorfmflluhuoourrmooaoocncttasaennrceussmuu.llffooFnnLaaUtteeOR((PPOFRSOO:SS)),, Intemational Symposium on Fluorinated Alky Organics in the Environment, TOXO17) perflu0rohexanesulfonate (PFHS) and perfluorooctanoate (PFOA) from ~human serum. FLUOROS: International Symposium on Fluorinated Alky Organics in the Environment,~TOX017) oOOfrrPggeaanrnilizuzaoattriioooonncfftooarrnEEcccSoounnloofommniiaccteCCo(o-P-ooFppOeeSrra)attaiioonnnd aa1nnsddSDDaleetvv.eellooppmmienntt ((OOEECCDD)) NNoovv.. 2211,, 22000022,. HHaazzaarrdd AAsssseessssmmeenntt Ohp(AtftcpPcw:e/er/swfslun~eovdrwoNo.oooevcect.caddn2.oe0or0rSgg2ud)/dlofooccnuuammteeen(nyPtS/F58O8//S00,),23a34n40d0,,Ieetsnn_S22a66lt44s.99_3377446655 22338844337788 11 11.11 3377z4~66550,000.hhtmml#3 (Accessed Nov. 2002) " ~ - BPPeGeddCeeInnF--1AAddMaaimmcses,,,Tethal lae,l.,TOoOrxariacllolEEoxxgppioosstsuuArrbeesttiOoaPPcFtFOO5SS73ff,oorr22208806DD, aayyss Suppresses Suppresses Iminunological lminunological, Function Function in in : B6C3FIMice. The Toxicologist Abstract #573, 2006. SMSeoeanackcaeattyseet.t aaTll.,o, xSSuuSbbcecihh8rro2onn4ii9cc-TT2oo6nx4iic,ciitt2yy00SSt2tuuddiieess oonn PPeerrfflluoorrooooscttaanneessuullffoonnaattec PPooatassssiiuamm SSaalltt.iinn CCyynnoommoollgguuss Monkeys. :Fox Sci 68:249-264, 2002 "TRTeaaskkeaapcctssoMrlVsLlL(aaa,nndd6BB, DD1)AAbbbybboPott.l. u22o000r07o7.e.cAAtccattniivovaiatteiiooAnncoiofdfMaMno6duusPseeeraafnlnuddcHrHouuommctaaannnePPeSeurrloofxsoinisasotoemmeeTPorPxoriolcitoiflferograaittcooarrl--AASccctitieivvnaactteesedd 95(1), 108-117. Receptors (ct, 1~6, 95(i), 108-117. ~') by P6rfluorooctanoic Acid and Perfluorooctane SulfonateToxicological Sciences T"FTaLanUnaaOkkRanOeetSl :aal,.,in22t00e00r5n5.a.tTTihohnyyarrlooiSiddymhhpooorrmsmiooonnmee sostanattFuulssuioinnriaanddauutllettdrrAaattlsskggyiivvOeernngaoonrriaacllsddooinsseetssheooffEnppveeirrrffloluunoomrreoonootcc,ttaTannOeeXssuOutl1ffo8on)naatee,. FLUOROS: International.Symposium on Fluorinated Alky Organics in the Environment, TOX018). T`ITnaatnnraaakkvaae,,noS,u,scettDaoalls..e2200o0f0661E2E5ff1ffee-ccLttassbeoolffePPdeerrfTfhllyuurooorrxooiooncect.taanneTeshsueullTffo~oxnniaacttoeelooognnis11t2255A11bsEErlliiammcitinna#att5ii7oo3hn iinn RRaattss a~fftteerr aa SSiinnggllee Intravenous Dose of 1251-Labele.d Thyroxine. The Toxicologist Abstract #573 TtThhhiaasyyceehrr,e,mKKi.c.a22l0000c22l..asEEnnivnviitrrhooennmnmaeetnintotanalallWWroeorprkokiritnnggonGGrhroouuumppa~:nPPeeexfrfpllouusoouirrinneaat0teeddenccvhhieermmoincicmaaellnss:t:aJJluuscsthtiieffmiicicacattaiiloosnn.ffoor iinncclluussiioonn ooff hip ewg orgreporsploworElWdG,/CpDdCV pdf this chemical class in the national report on human exposure http://www.ewg .org/reports/p feworld/pdf/EWG_CDC .pdf to environmental chemicals. T"MTahhtiibcbomoddaeelaaauuxnx,,deePttraaelln.,,atEEaxxlppEoovssauulrrudat.ttioooPPnsre.frflTluuoooxrrooSo0ecctt7aa4nn:ee3SS6u9ul-lf3fo8o~1n,aat2te0dd0uu3rr.iinngg PPrreeggnnaannccyy iinn RRaatt aanndd MMoouussee.. | : Maternal and Prenatal Evaluations. Tox Sci 74:369-381, 2003.. T"PTehhroofmmlfufooorrrdod,o,cPPi..an22e0000S22ulFFfioinnnaialcl RRAecepipodorrtPt::ot11a00s44sWiWuemeeeSkkaDDtii(eetPtaaFrrOyySCC.hhTrro-on6ni2icc95TT)oosixiniccRiiatttyys .aann(ddAbCCsatarrrcacicinntoooggneelnn)ii.cciittyy Study Study with with 6P33-MeMmrfo22lnu00t0o02hr2.o.ooPrPcaeetlrarssdnoooennsaSailenucglcfooosmmtnmuimucdnyAuiniccniiacdmatotPiinoookntnaesrfysrsoioudmmmevDDeSrr.la.olJJtpoo(ehhPdnnFbOBByuSut:DteernTn.h-ho6Goia2fTy9f.l.5oNN)ro.oinvvR22a55t,,s.220l0~00A22.b.sBBtreaencntccohhnmmlayar)r.kk doses doses from from the the 6-month oral dosing study in monkeys de~eloped by Dr. Gaylor. 33MM 22000033.. EEnnvviirroonnmmeennttaall aanndd HHeeaalltthh AAsssseessssmmeenntt ooff PPrefrflluuoorrooaoccttaannee SSuulltfbonniec AAcciidd aanndd Iltiss SSaaliltss.. rUUoKKsEE)nn.vviirroonnmmeennttaall AAggeennccyy 22000044.. EEnnvviirroonnmmeennttaall RRiisskk EEvvaalluuaattiioonn RReeppoorrtt:: PPeerrfflluuoorrOoooccttaanneessuullppbhoonnaattee (PFOS). tachment Page 6 of7 Attachment Page 6 otr7 22114455..00000099 STATE_02338899 STATE_02338899 UIUnS.fS.o.rEEmaPPtAAio22n00o00n33..tTTheooxIxinicctoeolgloorgagiticecadallR-RRiseekvviiIeenwwfooorfmfPaPeterirf.oflnluuoSoryroosotocecttmaan(nIeeRISSSuu)ll.ffooSnneaapttteee((mPPbFFeOOrSS2))00IIn3n.SSuEuxpptppeoorrnrttaoloffPSSeeuurmmRmmeaavrriyyew DIDnrrafafotfr.tm. ation on the Integrated Risk Information System (IRIS). September 2003. External Peer Review : AAttitascchhmmeenntt PPaaggee 77 ooff 77 22114455..00001100 SSTTAATTEE__0022333388990000 A pMMeeemmoorear To: Tomiie EnvironmenHtesaltlh Division Dito Date: To: February 26, 2007 John Stine, Environmental Hefilth Division Director . ie VViina:: LPaarylausSth.ibEatn,iHoenalmtehnRaislk SAsuseetssimoecntsUanidtASsuspaemr:v,iSessiojoorn asf * Pamela ShubaL Health Risk Assessment Unit Supervisor.~#,~'~ Fo TorSellotnenettOOoO ded From: Helen Goeden, Health Risk Assessment Unit A staff Hell Sn rohan vor ror Subject: Health Bv.se.d Values for.Perfluorooctanoic acid (PFOA) > Hud BUP ybeMs Dunn f eh DR) deed Ho irPONS-- e B02 In 2002 the.Minne,sota Department of Health (MDH) developed a HBV of 7 ppb for PFOA. Since 2002 additional toxicity data, toxicokinetic data, and rev.iews of preexisting data have been l~oduced. After a ccaarreeffuull rreevviieeww ooff tthhiiss iinnffoorrmmaattiioonn tthhee HHeeaalltthh RRiisskk AAsssseessssmmeenntt UUnniitt ssttaaffffrte-ec~ommmmeennddss tthhaatt tthhee IH-!BBVV ffoorr Totten "PPFFOOAA bbee lloowweerreedd 1to0 00..5 uugg//LL. (pppbb).). The following information was utilized in generating the revised HBV: Que gsr CChheemmicicaall - CCAASS## PFOA 335-67-1 EnEdnpdopionintt RRDfD((mmgg//kkgg-dd)) HHBBVV((uug~//Ll)) |Sued Shewce min Ses hepatic (liv6r) System, 0.00014 - 0..5 hheemmoototoppooieiettiicc ((bblloooodd)) mpl nt system, developmental, SSoouurrccee MDH 2007 and immune system Cn Sar SE Tato, FASE More detailed information, supporting the developmentofthe HBV, is attached. Please be advisetl that, yin Fins svat although we believe that this. number will provide an adequate level of protection, there is a degree of. a Pn, Betl uncertainty associaWxl with all HBVs, and theylshould be considered provisional. Professional judgment SyA i have been conducted. `TThhee MMDDHH';ss aauutthhoorriittyy ttoo pprroommuullggaattee-hheeaalltthh rriisskk lliimmiittss.urinddeerrtthhee GGrroouunnddwwaatteerr PPrrootteeccttiioonn AAcctt iiss lliimmiitteedd 1to0 .s~iitmuaattiioonnss ~whheert~e.tdteeggrraaddaattii6onn hhaassaallrreedaddyyooccccuurrrreedd.. SSiimmiillaarrllyy,~-hheeaalltthh--bbaasseedd vvaalluueess,, wwhhiicchh aarree uunn--, ei: promulgated exposure values, serve as interim advice issued for specific sites where a contaminant has ee in ce edor ie es ess omo been detected. As such, neither health risk limits nor health;based values are developed for the purpose misth eerl, y of providing an upper limit for.degradation. J Soler I_arry Gust,'MDH fe Ler Pare Shubat, MDH To SA ie? Rim Messing, MDH Cathy Villas-Horns, MDA ShelleyBurman, MPCA Paul Hoff, MPCA DougWetzstein,.MPCA een 0 rom po 7HL E109 Environmental Health Division ,, 625 N. Robert St., P.O. Box 64975, St. Paul, MN,'55164~0975 * (651) 201-4899 bttp'~lw ww .Iw~lth.staa~,nm.tt~ 2114455..000011 STATE_02338901 AATTTTAACCHHMMEENNTT "DDAATTAA FFOORR DDEERRIIVVAATTIIOONN OOFF GGRROOUUNNDD WWAATTEERR HHEEAALLTTHH BBAASSEEDD VVAALLUUEE ((HBBYV)) CChheemmiiccaall NNaammee:: PPeerrffiluuoorrooooccttaanncoiicc AAcciidd ((PPFFOOAA)) (CCAASS:: 333355--6677--11((aacciidd)) 33882255.-2266--11 ((aammmmoonniiuumm ssaalltt,, AAPPFFOO)) 22339955--0000--88((ppoottaassssiiuumms,asalltt) 333355--9955--55 ((ssooddiiuumm ssaalltt)) NNoonn--CCaanncceerr HHeeaalltthh BBaasseedd VVaalluuee ((HBBYV)) == 00..55uugg//LL ==to(txoixciictityyvvaalluuee,,mma~rlke~/d) x((lrealtaitivveessoouurrcceeccoonntrtriibbuuttiioonn))xx((11000000uuggl/smigg)) ((iinnttaakkee rraattee,,-LLifkkgg--dd)) , ==((00..0000001148mme(fg0k/k0eg/5/d3d))Lxixk(g00i..d22a))xyx) ((11000000uug~//mg~)) (0.053 Lfkg(.day) =0Sug/L TTooxxiicciittyy vvaalluuee:: 00..0000001144 mmgg//kkgg--dd ((CCyynnoommoollgguuss mmoonnkkeeyyss)) SSoouurrcceeooffttooxxiicciittyy vvaalluuee:: MMDDHH22000077((RRIIDDddeerivredibhyyvMeDHd) PDPooiosinnettoMofeftDDreiepcpaarArtdtujururees::tme nt: 7" LL0OO(AAtEoELaL,d,j33usmmtgfg/o/krkggh--ddalf durationof3.8years in humans versus 20 Dose Metric Adjustment: Total uncertainty factor: 7dd3aa00yy0.s(stoiinnammdajaullseetCfCoyyrpnhooammlfoo-llligfgeussdmmuoroanntkikoeenyYsos))f 3.8 years in humans versus 20 . UF allocation: Total uncertainty UF allocation: factor.. ~ a333n0iid0nntt1er0rssLppOeecAciiT~sLot-ox4xioice-ooNddyOynnAaaEmmLiicc(fddoiciffIffecrrkeennoccfees,, n11o00eiifnnftreracatssppdeeo'ccsiiecessinvvaatrfhiieaabbriiil'iiittt)eyr,s, ' sasttnuudddyy1))0 LOAEI,.to-NOAP.I, (for lack Of a .. no effect dose in the critical CCCroriirttiiicciaalcl aeeflfffeeeccfttf((ses))c**t::s): ~~ Reduced nuomferbythreocytres, iInnccrreeaasseedd rreellaattiivvee lliivveerr wweeiigghhtt Reduced number of erythroeytes, rreedduucceedd bbooddyy wweeiigghhtt nanddbbooddy~. + Co-critical effect(s)*: "" ~ " wweeiigghhtt ggaaiinn,, ddeevveellooppmmeennttaall eeffffeecttss ((,ddeeccrreeaasseedd wweeiigghhtt ggiainn,, ddeellaayyeedd beddheeavvveeillooopprmmteeensnttt)aa,llsppurrpoopggrrreeessssss,e, dhhyyIppgooMaaccttititivevrees:rreessppoonnssee iinn nniiccoottiinnee--iinndduucceedd AAddddiittivviittyy eennddppooiinntt(ss)):: HiH.bemeepmphaaautvtniiicceor(isltviyevessertt)r)e,)msssuyyspt.tpeerrmen,s,shheeedmraaIgatMmoppofoiiteieetr:tisiec ((bblloooodd)) ssyysstiecmm,, ddeevveellooppmmeenntta)l,, SSeeccoonnddaarryyeeffffeecc(t(ssy)"*:: DDrimeeescmcorrrueepatnaisseoeensddsy,ppsotoaeslsmtttaenaratetdaallmssauurrmvvmiivvaaarll,y, iignnlccaar'needadaseseviiennltothhpeemeiinnnctcii,ddeednneccceeroeofaffsfueuldllltllhiityteoerird the aden cortex rhheoosrrommropontnieoessns(0,T"a44lt&&ereTTd33)m),,addmiissmrruuapprttyiioognnloaofnfdsspdpooenvntetaalonnpceoomuuessnbbt,eehhdaaevvciw,ioo,rar,,seccdhhaalhnnyggereossidiinn **ffoorreexxppllaannsaitioonnoofftteermmssssoeeGGlolossssaart~hyyeliooaceadatrteceddnaaattl::hchottrpt'wJelxwwsw.healthlssttaattee,mmonv.vusr~l/idvivlse/tehV/ggrroouunnddswat'tere/hrrlgwwllgglloossssaarr3ytabhitmndl AAtatacchhmeenn.t- PPaaggee11 ooff77 22114455..00001122 STATE_02338902 STATE_02338902 `Cancer Health Risk Limit (HRL) = NA Cance~ Health Risk Limit (HRL) = N/A VVoolalattiillee:: NNoo : `SToSurumimcmmitaayrryyVoaolffucechha(aRnnIggDe)es:s ssiinnccee 22000022 HHBBVV:: TIImmemotppxrrriicoocivvtaeeydddVjuttaooslxxtuimiecceoon(kkgtiifnnbDeeat)tsi:ieccd((eoe..ngg..h,ahhlfla-fll-fi-Jflfieefe)d)iifinnffe~or'roemrnmacteasitoibonentaawllelloeownweehddufmfooarnttshh.e.eaniindnccmoo.orrppnookrreaayttisioonanonofdfaaa 717000---fffooolllddddddeoocs~ree--ase in tmheettroitcaladUjFu.stmIne2nt b0asaed300o-nf2ohldalff-olicfoord3iffeinretnercsopsecbieetsweexetnrahpuolmaatniosna+nd1m0 sounbkcehyrsonaincd-tao-!c0h-rfoonlidcd)ewLa-rscausseeind1ttho0eaaddtoddtrraeelssUss uuFnn,cIcenerrt2taa0ii0nnt2tiieeass3aa0rr-oofuounlndddfttaoocxxtiioccrook(ki3innicentttiieccrsss..pecies ex~trapolation + 10 subchronic-to-chronic) was used IIPnnOttaaAkkee,rrauattneel::ike most ground walcr contaminants, has along half-life and therefore will accumulate in the PbbPboFEddOOyyiAAff,fwrurieenlpplleeirkaaeettaeemcddhoeeaxxstpppooglssraouuturreene.sdo6(ccwscctaueurtaredssryo-ocsvvoteenartrteall)omo.nnigng"-T-aphnpeeetrsrli,oiehnodagdsstoohaofffltiotimmneige..ehEEavtlvfoee-nlrntieftuuaeacalahllnlyysdttttehhhaeeedriyinenfstteotearrmtneeaawlcloccinlooldnnaicecteecinnuotWmnrsaautitiiisaootnneooifnf the. . PeqFuOivAalwenitltl oreaapcphroaxpilmaatetaeuly(s5tehaadlyf-sitvaetes).. ITnhtehelecnagstehooff PtiFmOeAtotrheatcihmest1eadstyesatdayt-estcaotnedwiotiuolnds ibse eaaWpqpappusrrivooxaxtiliiemmmnaaett-tteeowlleyyaipg11ph99rtoyyeexedaaimarrssvae((tr5e5alxxgyehh5iuuhnmmtaaalafknn-eloihhvfaaeallsffn-,-liiIufnfepptooheffer33-c..e8a8nsdyyeeecaoarofrsns)P)s.,FuTTOmhteAieer tiiohnnvetteaatrkkimeethraeeatttfeeoirsesstetlele1eac9cdtytyeee-ddasfrtfoasotorertfthwhlee.igfrrueeeidvv0ii.b.sse0ee5dd3HHLBBiVYkg t0wdh.)ae..saTTachhcitiiussmmiiuennl-ttawaatkkeieeio.granhatttoeefdtiihnnaeccvoocerrhrpapeogaorneraia(icienasstlatotkhhveeeeohrhftiiggiahhnmeeerur.piinpntteaark-keeenrrdaattceeossneesaaurrmtlyyeiirnnollviiffeeer((tih.-e.e.,~fiiirnnsfftaa1nn9ttssyaaennaddrsccohhifilllddifrreee.nn()0).aa0ss53wwe.elIl_ll/l1a(g5s- the aecumulation of the chemical over time. `DCCeoolnnassyiiedddeerrdaaettviieoolnnoopofmfSeSenentnsisaitntidiyvgeerPPoowoptpuhuldlaaetftiiioocnintsss:: in the offsprionfg females mic expos.edduringpregnancy Dhshaahevvoleaewbynbeeedetehnndarterevtepehpoelorordtpteeemvddeeaalnttotdpdaomonsesdeneltgleaervloveweellftsshfsesdicitmmesifilialcaarircrtsmt{ao0itnithnhtelheyeLLoOdOfuAfAesEpIL~troiIof.eiofgxftpohtofhes.efueccrmrreiiaitdilcucearasi.lsmnstgtiuucpdderyyeexg((33npmaomens/cegkyd/kgrdg-au-dtdr)hi)e.n.rgStStphtuaurdendigieaenfssathneharcavyvee bssbhciiretotnhhwt..rPnPiootoshsssawsiteibbtrlhleeeeHHedvBeBavVlVeuslsa,o,tbpebamdas:seeen1ddt)oaoalnnelpfopfnreogrc-ttetsceoatrirometnemoxofapefaionasplupycrrreedegugt--nenaeatnxionpttewowxosopuomromneasaun1nr0eaatndnhuddermhhinoeegrtrfhfpeeerttreusgfs,n,rwawoenm~rcrobyeiarrlaatlsthshootecracaaltghlcceuaulnla1aat9tefeytddee..raTTsww, Oo aaa0scccndcecdnuu22mam))iriulaaolassasththiwioooorenrntrot-e-o{vtvceeearvermmraetltueiixmaxmptepeeoodsaas:unnur1ddre)euua---ttiillleeoiixxznzppegeodod-satsaeuurrrttmoieimmtteoeeoax--apwwnnoeeisiiniunggfhrfhaeatntneetr-dtd..eTiiTxnhnthpatekoealeks.loeuonrrnrgeoag-ttt-teeotee00trrh..mm00ee55exm33xpoLLpoito/shkksueggu:rr-rddefe.r.sosccTTmeehhnnbeaeairrrssiithohhoofoitrnootrc-cttaooegrerrpepmnao1rree2aaxxityppeeeododas:surusrr,ee . Lcisockemgn-aadri.oTddhiieddtffFstOfuiUlfitiCninC-gtorpr~opbto-errn~IttE-ieaS~lCfEHfUmBRV~R:lU~IfiAtoiLbro~bNio6otVvhe~srfc-Gtei.n~eadr-Bibuo~fstd-wtielidrffe~UhfAiilliggzhSEe-fr&iYtyhooauunnntgghT]eAhHT-fA~BRtY-CmIb'AaffAst~KetSdko-~n(i~tei~hftefs00e~.l22e22c11t.e..d........................ Lcerr/iikttigcc-aadll.ssTttuhuddeyyrdiinnsummlotoinnnkgkeepyyosst..e,ntial HBVs for both scenarios were higher than the ]-IBV based on the selected Atachment Page 2of 7 Attachment- Page 2 of 7 22114455..00001133 SSTTAATTEE__0022333388990033 `SSuummmmarayr~ooffttooxxlilctiyty .t,ets~t,i.tnigng ffoorr hhe~aalltthh eeffffeeccttss lidd.eennttiiffiite~dl iinn tthhee HIte~aalltthh SSttaannddaarrddss SSttaattuuttee:: . TToe~stcead?? Ob EsenSrdSevoecacc.tr.iinoens , Observations~ Yes Immu~,,gtoxicity Yes Yes Development Yes Yeo Reproductive Yes Yes Neurotoxicity Yes Effects? Yes Yea2 " ' Yes3 r Unclear Yes~' - ec: Sven icaingTospeciehealthectwes nt conducted for sche, eormation hodTat cay Bo Note: Even if testing for a specific health effect was not conducted for this chexnical information about that effect may im vilfromsd conducted oc theripsa. Mt chars bavebeensbjcbo lil ic in hich avail~bl~ fromstudies onduetezt for other p~t-p~ea. Most ehe,micals have bee~ zub eet to multiple studies iU which eserchrs nif dosewheremoetwereabervd,a he komt doe akcaus onomore cfc. A oxicity . researchers identify a dose.where no effects were observed, and the lowest dose that caused one or rare effects. A toxicity alu bce oth fectcaved ths lowes doescroll vial tis + conse proectine ofal es facts value based on the effect observed at the lowest dose across all available studies is considered p~-0tective ofall other effects dha cea tiger dos, that ~ at higher doses. CHCooormmmmmoennenattlssoopnenreetxxutrteebnantttioooffnttee(ss5ttii,nnggdoeorcrerfeeffaefsecectdtss:t:hyrosine (4) and wiodotbyrorine (3) levels) have been booreHbbessoneerirrmdvve,eeonddntai.iinlfniplleaeadbbrtooaurrsrasabtteoaocrtroiyyonnaadnsnaiirm(myeaa.lgelssf.,fasedttcetddcsoorse~eaeslleeedvveetlhlssyaraoppxppirrnooexxi(im'mI'a4at)teeallynyd33--trffiooillodddohhitihggyhhereorrntthihnaaenn(ttThh3ee)LLlOeOvAAeElEsLL) haaannvddehhbaaevveene~ 2*bSSehehonorrittd-teteenrrtmmifieiimdmmm~uun~noeoleot0oxnxidiccaiirttyyyessfttfueudciticse~ss hhaavvee sshhoowwnn tthhaatt PPFFOOAA eexxppoossuurree ssuupppprreesssseess hhuummoorraa-l] iimmimmunniittyy aanndd mmhaaavyye aabddevveeenrrssieedlleyyntaaifffffieeeccdtt accsellcllo-mdcieridatitcaateelddefiimfmemcmtusun.niittyy a at doses doses similar similar to to th the critical critical study .study LOAEL. LOAEL These These effects effects. 3h3DaDevveeevbleeoloepnpmmeidneetnnattalilfiddeeedllaaayysssc,,ollo-ocwwreietrribcboaoldedyfyfweWecitesgi.ghhttw/weieigghhtt ggaaiinn aanndd bbeehhaavviioorr iinn ooffffsspprriinngg hhaavvee bbeeeennoobbsseerrvveedd aatt ddfooolssdeehllieegvvheeellrsssstihimamniiltalhraettoroLtOthhAeeELLLOOAAaEdEdLiL.t.ioTTnhahelessdeeeveceffflfecoccptsmsehhnaatvvaeel bbfeeeeecnntiisddee(nndtetiicffriieeedadasasesdc.copo-u-cpcirviiitciacbaailllieetffyff,eeccdtetssl..ayAAsttiddnooesyseee:ss 33-- ooofobppseledennrihivnniegggd,h,.eiinErnfcctfrhreeeacaantssseethddoeciinLcncucOiirdAdieennEngccIaee.oaofddffdofuisutleillosl--n!laaitptletperdrreorrveexessilooomrrpapptimtiliooeynnn3,t,aaalollletiefdzrfaeahtctiitoigsohn(nesdriiennhcarmmevaaeasmmbemdemaepanruryyipdggevlnliataaninbfddiilieddtdyeevav, seedllesooleappcymmosenenidnnta0)reyyaareree "Teoeffbhffseeecectrstvr.see.sd,u.ltEsffoecttfhs oc2c-guernrienrgataitodnaolsesstuadpypriondxiicmataetetlyht3ffeolld htigihsenrohtaavfeebcetene identified as secondary by treatment.Fulllid"er ru" 'rrteleTsshooeerrppdrtteiifosounrnlotwwsmaaomssfaoottbhbesesmee2rar=vvleegddteo~aaxtritacddtiioto0yssnoearllleevsavteedtlliisdsry3e3-c-iffneoodfllifddceahchttiieggothhnheetarrhtttefhheaadrnnteivtlthiehteleyoiLLpsOOinnAAogEtoEaLrLf,gf,eahh~nooiiiwws~emlev.vbeAeyrlr,t,li~iettrtsfiesidiueumninaicctlm.leemaaFarrurwwlyhhIeg-etllthiha~eernr"dtthiiss t`rdeheesavvuneeltlltoehopdepmcmfrerieontnmittcaddlmuusrartiitneungrgdnyttahhLleeOtollAaxaecEittcaLaitttiyiodoonunaarrliianppdgeepirr~riirooeocgddtnewwafanafsecscyoot.bbossIneenrrctvhvreeeedaddsiieennvdmemiilnoicecpo~iiednexegxpnpcooeorsogsefeaddnfiuttsloomldd-. oloAtsseleetrellerreevevdeselolmssrpsastllmiiigogmnhhttaallrynyydhhgiiglgahhneedrr alStsathHHletayerynprapattoohtiaiaeoocenncitssirviviietnenircmremaesalsapmpsmotomunmnadssyraeeryLyttgooOnglnAilaacintcnoqdotdldit.idnedneevuevherheilanlaosogspbpmpbemeereeeenngnntonthobahbasnasevcveryeerv.bvebIeendedcciearninenaiinndseeeeoodndnntaiianfteitcaeailldd2mnmeai3nsicccaateeesaseoaencinfcoddfonuhnhfdladlaasrasrlbriiybyteteeeeefeerfnfnfreeecicdsncttocsslr:l.upudtdieeoddn and. iinntthhee llisstt ooff ccsoot-u-ccdiryittaictcaadlloeefsfffeelccottvsse..sAArdedoasotes-er-treehllaaatnteedtdihinencLcrrOeeaAasEseeLii,nnahatotaawxxeiivaaeiirnn,tthhhieefsfeeemfmfaealcleterwraaattsss wnwoaatssrorebepspoe,orrrtvteeeddd iiinnnttmhhaeelcechhsrrowoninitichc h22yigyeheaearrr asbbctoouuddtdyyeynbbaeuutorrdnddoaeetsnneassllooeerrvxeipinlnoss09guOrreddeaaattyyeodrssottthusuaddeniiseetssahpuueptiirLifloiOizxziAiinmnEggahLthie,ighglhoyhewe3rr-dddfvoooessrede,s.sh.t.ihDDgihisiesserrrftuufpehptcatiitnoownntoahofsefcnsrspoiptotoinonctbataalsnnescertvooueuuddssy ibLbneeOhmhaaAavvilLieoosrrwbffaooivtllehllbo.ohwewieiginnhngger. obaotsecbseustrteiernvvgneeeddoananandtdaalarereexipiddoeesnnutitrifefiiteeodddaaosssaaessseeaccpoopnnrddoaaxrriyymeefafftfeeelccyt,.3TT-fhhoeeldSShAAigBBhh.hoarastsrhreaenccoothmmemmcerenintdideeeaddl~aa-dtddudidtiytiiooLnnOaalAlnne.heu-~ur.roholaloovggeiiecb.aealel n .testing. Aachen Attachment- PPaaggee 33 ooff 77. 22114455..00001144 SSTTAATTEE__0022333388990044 `TThhee ffoolllloowwiinngg ssbouurrcceess wweerree rreevviieewweedd iinn tthhee pprreeppaarraattiioonnoofftthhee HHBBYV:: AAPennrddfelerurssoeernno,a,lMMkEyEl,a,ceeittd,.saalli,.n, 2M200o00n66kPPehhayarr~smmaPacrcoookbkiininnegettiticcheMMDoeodtdeeerllminiignno.aognfftSSsaatotuufrrLaa.boblnleeg,, RRPelenanasalmlaRReHesasolorfrp-pLttiiiovoennso.offTo.xicology 2P222e77r:f:l11u55o66r--o11a66l4k4.y. lacids in Monkeys.- Probing the Determinants of Long Plasma Half-Lives. Toxicology A(`APbbPbboAotRtttGBB),,CiC_nIJmWWeodloiflaf,t,iKKnPPg tDDhaeassd,,eCCvSSelLLoapaumu.e.n3~t00a00l77.t,oRRxoiolclieetoyooffpfie~preroorxxliiussooormomoeecpptroarolnilcififeecraraacttioordra(acPcttFiivvOaaAtt)eeddrirenectcehepepttmooorru--saaell.pphhaTahe `T(PTooPxxAiiccRoolcloo0ggiiinssttm((sesuudbbiammtiiitntttgeeddthffeoorrdetthvheeel22o00p00m77eaannntannluuataollxSSicOOitTTy mecting). of perfluorooctanoie meeting), acid (PFOA) in the mouse. The AACCGGIIHH DDooccuummenetnatattiioonnooffTTLLVVss 22000011.. AAmmmmoonniiuumm PPeerrfflluuoorrooooccttaannooataet.e. OBBurutateennDhhooosffitf,n,geettfaaoll..r,622M00o00n22t..hTTso.oxxiTicocixitityycooolf.foAAgimmcmamloonSnciiiuuemmncePPseerf6ff9llu:u2oo4rr4oo-oo2cc5tt7aa,nnooaattee iinn MMaallee CCyynnoommoollgguuss MMoonnkkeeyyss AAfftt.eerr Oral Dosing for 6 Months. Toxicological Sciences 69:244-257. ' TBBouuxttieecanohhlooofgffficJJaLLl,, eeSttcaialel..n,c22e00s0tM482aa:.. 3PP9hh4aar-rmr4na0ac6cookiknineettiiccssooffppeerrfflluuoor~ooooctcat~nooaattes iinn CCyynnoommo;ollgguuss mmoonnkkeeyys.s. - Toxicolggical Sciences 82:394-406 BBuutteennhhooff,, tet aalL,, 22000044bb.. TThhee RReepprrotdduhcctfiivvee TTooxxiiccoollooggyyooffAAmzmnomnoinuiurria PPeerrfflluuoorrooooccttaannooaattee ((AAFFOO))iin tthhee RRaatt.. TTooxxiiccoollooggyy i19966::9955--111166.. - R`BBeuugtetTneohnxohfoafefnetfdt aaPll,h, a220r000m44c3c.9.:CC3h6ha3ar-ra3ac8ct0te.erriizzaattiioonn ooff rriisskkooffggeenneerraall ppooppuullaattiioonn eexxppoossuurree ttoo LE. ppeerrfflluuoorrooooecttaar~no.oaattee.. Reg Tox and Pharm 39:363-380. J BBuui[ecnnhhooffcfetft aalL.,, 22000055.. RReessppoonnssee ttoo leettteerr ttootthhee eeddiittoorr..RReegg TTooxx aannddPPhhaamm4422::114466--114477., `CACmAAmT'IoTTn22i000u02m2..PWWeerefsslttuVoVirriorgogicintniaianaoDDaetepepaa(rrCut8mm)eenAntstosoeffsEEsnmnvevinirrtooonnfmmeTenontxtaiaclliPPtryrooTtteeeccattiimoonn(C((DDAETEPTP)))., RAAeupugogruuts.stt 22000022.. FFiinnaall Ammonium Perfluorooctanoate (C8) Assessment of To.xicity Team (CATF) Report. CCPlhleaewrwemelallcloHHkJiJ,n,TTeatainncYYMoMMd,,eAlAinndndegetrrosseeEnnstMMiEmE.a.tSSeoocPciiFeetOtyyoAofEfRxRipiossskku.ArAnenasallAyyssssiisoscppirraeetsseeednnttwaaitttiiohonnMDDeeaecse.u. r22e000d066B..loAAoppdp.pliliccaattiioonn ooff " `PCCho_o_nnacc~e.e_nn~i_t.r~ra_a.ttkiiio.onnn.~ssti~ii.n~n._MHH__~uu!mm!anagnn._PPoto~ppu..ul~al_at_ittioio_n.nsms...~teAA..bPbs_stFtr_rOaacActt..~MMp2~2.._C-mC.1~.1_.... A.ss. ~!.at..e~.. ~.ith...M. e_~.U . .r~d.~ .Blood . 'DeWit JC, CB Copeland and RW Lusbke. 2007. Dose-responseofpefluorooctanoic acid-induced mDiimemeemmWtuiunnignto)oJm.Cmod,guCdlBualtaCitiooopnneiilnannaaddduualnlttdCCRS5TW7BBLLIIJuG6ebmmkiiecce.e.2. 0TT0hh7ee.DTToooxxsieicc-oorleloosgpgioissntts((essuuobbfmmpieittrttfeeldduofforoorrottchhteean22o00i00c77a.AAcnindnn-uiunaadlluSScOOedTT meeting). l`EeBrvnoemlnseeatttnEEd,,ceeettrtaaall.i.n2200h0e0a66l2at..hCCpoaormmammmuetnueinritst.yy EEJxxOppEoosMsuur4ree8(tt8oo)PP7e7er1rff.ll7uu9oo.rrooooccttaannooaattee:: RReellaattiioonnsshhiippss bbeettwweeeenn sseerruumm levels and certain health parameters. JOEM 48(8)771779. EBmmmmetettt EE,, eett aall.. 22000066bb.. CCoommmmunuintityy EExxppoossuurreettooPPeerrfflluuoorrooooccttaannooaattee:: RReellaattiioonn.sshhiippss bbeettwweeeenn sseerruumm ccoonncceennttrraattiioonnssaanndd eexxppoossuurree ssoouurrcceess.. JJOOEEMM 4488((88))775599--1700.. FpFreeennntatottnnalSSEaE,n,dCCaLcLatauaut,,iEEonPPaHlHienixnepesos,s, uJJrRReTTihhniJmbbioocddee,eaaTuuhx,e, aaTnnoddxiSScSoSlWWohgiihlsiette..(LsLuoobnnmggi-=tttieeerrdmfmohhreeatalhlttehh2eef0fff0ee7~cttA~snoonfufaPPlFFOSOAOATaafftteerr pmme~eeeetntiainntaggl)).a. nd lactationaI exposure in mic~. The Toxicologist (submitted for the 2007 Annual SOT AAt~aacchhmmeenntt-- PPaagge4e4 ooff17 22114455..00001155, SSTTAATTEE__0022333388990055 FFinooooFoddoSSdt,taannCddoaanrrsddussmAAegrgeePnnrccoyydu((caatUUsnnaiinttededdthKKeiiEnnnggvddioromomnGGmoeonvvtee.rrnnSmmeeecnnottnAAdggeDernnaccfyyt)),W, oCCrookmmimnmigitPtttaepeeeoornnoTTnooxtxihiceciiTttyoyoloeffrCaChbheleemmiDcaicaialllyss IIinnnttFaakokeoedffo,orrCPPoeencrsfluloomuureroorooPccrttoaadnnucociitccsAAacnciiddd.t((hMeMEaanyyv22i00ro006n6)m).. ent. Second Draft Working Paper on the Tolerable Daily .FFinooFoooddodSSt,taaCnnoddnaarrsddussmAAegrgePenrnoccdyyu((caatUUsnaninittdeeddtKhKeiinnEggnvddioormmonGGmoeovnvete.rrnmMmeenintt nAAggeouenfnctctyhy)e),e,JCCuolsomymmm1i1,tittt2ee0ee0oo6nnmeTTeootrxiiicncigit.tyy ooffCChheemmicicaallss in Food, Consumer Products and the Environment. Minutes of the July 11, 2006 meeting. FFthooeooEddnvSSittaranonnddmaaerrdndtss.AAggCeennOccTyy,,SCCtaootmmemmmieintttteeoeenootnnhTeTooTsoxilicceiirttayybl((CeCDOOaTTi)l)oyofIfCnCthahekememifciocaralPlsseriinnluFFooorooodda,,ciCCaoonnncssiuucmmAeecrriPPdrr(oodNduoucvcttessmaabnneddr 2006) the Environment. 2006). COT Statement on the Tolerable Daily Intake for PerfluoroocLanoie Acid (November Gw`aGeteremrrmaawnnitMMhiitnhiensgturiyiodoseffHtHseuearbalsltytthhanDDcreriisnnpkkeiirnnfgglWW uaortaoetcercrCtCoarnoncmimcimsaisscisioidonn(..PPPFrrOooAvvi)issaiioonnndaaplleeefvvlaaullouuraaottoiioconnioaofnfePPsFFuTTlfiionnnaddtrreiinn(kkPiiRnnOggS.) as `eewwxxaaaantmmeeprrlp.welpesdi.sft.hJJtuuhlleyyg11u33i,,d72e.000s06u6.b. shhtalanpcpJe/swp:wewrf.luuum0mruwoeoebcltutbanundnodeicessaaacmmidtt,(ddPeeEl/OoubbAaai)-nianfnofdo-pp-perrerfesluss~eo-rnoetoi~cnr.tgtaernrtmegrsdou/nlpfdof/tno-aifnt-e-idn(dP-nrFikOniSnki)gn-ag-s.:~ watelLlxlf T`GGouuxrruuSggceei eo8ttXaa1ll,),9223000-0616,0..7CG.reectiee EExxpprreessssiioonn PPrrooffill~e iinn RRaattLLiviveerrTTrreeaatteedd WWiitthh-.PPeerrfflluuoorroooaccttaannooiicc AAcciidd((PPFFOOAA).). Tox Sci 89(1)93-107. HHineennFddeeterarlssooannnWWdMMNaeaonnndadtMMalAAMSSimmciietthh2F20o00l07l7.o.wPPienergffluIlnoruUotooecrrtaoon0Eoixccapactcaiidasd(u(nPPoFFtOOoiAAc8))-a2anndFdlPPoeeorrrffoltuhcoulrooomrneoornnaoAnnlocaioenahoacocilicdd(((FPPFTENNOAA.)) Toxicologicsl in Fetal and Toxicological Sciences Neonatal Sciences S5M52.61. Mice Following 95(2)452-61. In Utero Exposure to 8-2 Fluorotelomer Alcohol (FTOH). HPHliia~ncade~enrdt!l.aili~cear,,nPPdMoMc,tE,EtiMMoynylalccl.hhtegreeacsnsts.tp,,oSSrtAApGhGaaarnamnnaocnno,k,Ji.JLnLetBBi.uuc.setcinnnhooaft,f,.G.QTLLo.KKxeioncnooeel4.odyJ2gJry1yr..122001003559..-PP1e4.er8~f.rlfu!ourooroocotcatannooaattee:: Placental and lactati0nal transport-pharmacokinetics in rats. Toxicology 211 :. 139-148. HaHitnisnddfeoerldtliitoetw~rieentgtaoalrla.,l, 22g00a006v6.a.gAAeggweietefhfffaeecmtcmoootnnnppieurmfelupoerrroloucfotarnooloactteua((nPPaFFosOOA(A)rA)pPplFloaOass)mmoTaaocxcoiconccnoeelnt~ot,grtyraaa2tt2iio5onn:n1ii9nno5pp-oo2sas0tt3-,wwieeaanneiinngg rats following oral gavage with ammonium.perfluorooetanoate (APFO) Toxicology 225:195-203. lJpooehhraafnnlsassosooonon,c,tNNan,,oeitcaala,.c,i22d0000(66P,~FNNOeAeo)onnacatataualslee~sxdpexorsaunprgetetdooobppeeehrsnafqivuuiuooorruoorrooacctntaaednneiensscuurlleffaoosnneaadtteesu((sPcPFeRpOOtiSSb))i.l'aainntddyofthe ch'olinergic Spyesntqeumoironoactualnomicicaec.iTd.h(PeFTOorAi)coclaougsiesstdAebrsatnrgaecdt #be1h4a5v8iour and increased susceptibility of the eh01inergic system in ~ldult mice. The Toxicologist Abstract # 1458 EKKxaparto,r,s~muaarnneAoA,f,BPIeEireiccssoronn,Bl,B vvuiannCBBhoaevamevilrec,l,aPPliOsOtDDnhaarmmoaeuergruhutLdda,,ccMMttAAiluonnene,,LAAeGvOleyllynsnnon,frMSaLtLicigghnneeeldllHlaaunnmddaG0n,LLMiiinnlddkssilar~nomdmS..e220r000u66m.. and a TemporalTrend, 1996 Exposure of Perfinoroinateit and a Temporal Trend, 1996 C~- h22e00m004ic4, aii,nnls Sweden.EHP OnlineNovemb20e06r. throughLaietation -Levels of Matched Sweden. EFIP Online November_2006. Human Milk and Serum KaKee.nnnneeddyy eett aall.., 22000044.. TThhee TTooxxiiccoollooggyyooffPPeerrfflluuoorooooccttaannocaatte.. CCrriittiiccaall RReevviieewwss iinn TTooxxiiccoollooggyy 3344((44)):335511~- 383. . _ , - aKKnuuidmdaoolsNN. TaahnndedYYJouKKranawawlaoassfhhiiTmomzaaic22o00l00o33g..iTcToaoslxiSiccciiitteyynacanensdd'2tt8oo(xx2ii)cc4oo9kk-ii5nn7ee.tticcss ooff ppeeerffiluuoorrooo~cttaannooiiec aacc_iidd iinn hhuummaasnss aanndd animals. The lournal of Toxicological Sciences 28(2)49-57. .. LLdeaaruui,,vaCCt,,ivJJZeL,s-.BBTuutot~exnnAolipfofpff,l, aaPnnhddaJJrMmM 1RR9od8g:ge2res3r.1s..2220040104.4,. TThhe ddeevveellooppmmeennttaall ttoxiocityrooffipeecrfflcluuoorirooaallykkyyllaacciiddssaanndd tthheeiir derivatives. Tox Appl Pharm 198:231-241. Atattcahchmmenetnt.- PPaaggee55 ooff 77 22114455..00001166 STATE_02338906 STATE_02338906 UPUeS.cS.f.lEEunonvrvioiorrocotnnammnecenintctaaAllcPPirrdoottaeenccdttiiioosnn SAAlggsee.nnccyy.. NNoovveemmbbere44r,~ 22000022. RReevviisseedd DDrraafftt HHaazzaarrdd AAsssseessssmmeenntt ooff Pertluorooctanoic Acid and Its Salts. `UUWS.eS.i.gEEhntnvviinirrtoohnnemmeUennntitataelldPPrSrootttaeetCctetiisoonnAAAnggeUenpndccayyt.e..OOcectitpootbabpee.rrg22o00v00h44.w. aEEststteinmsasattieeddnPPceerer C/CadappiiinttaakW Wianatgtee/rrpIIennrggeecssattiipootnnaan)ndd BBooddyy Weight in the United States - An ~Update.:.http://WWW,eOa~gov/waterscienee/drinkinglpe.rcapim. )-. `HUUe.SaS.l.tEEhnnEvvfiifrreoocnntmmseeAnnststaaollciPParrtooteteedccwttiiiootnnh AAEgxgepenoncscyuy.r.eJJaaonnuuPaaerrfyyl44v,,or22o00c00c55t..anDDcriraacffttARRciiisdskknAAdssssIeesssssSmmaleetnnst.toofftthhee PPootteennttiiaall HHuummaann hupeps gioviov ppUplaospfn oarisykim Health Effect~ Associated with Exposure t0 http:l/www.epa.govtoppt/pfoa/pfoarisk.htm Perfluorooctanoic Acid and I!s Salts. -. UPUoS.tSe..ntEEinnavlviiHrroounnmmmaeennnttaHaellaPPlrrtoohtteeEccttfiiooenn AAAggseesnnocccyyi.a. lMMeadayywi22t0.0h006E6.~xpSSoAAsBBurRReee0vviiePewewrolofufoErEoPPoAAc't'ssaDnDroariafcfttARRciiissdkkaAAnsdssslsessssuSmnleensnttoofftthhee gitpo: vlcspaabipdf06l00s6.phdf Potential Human Health Effects Associated with http:llwww.epa.~vlsablodffsab 06 006._~f Exposure to Perfluorooctanoic Acid and Its Salts. ChUUrS.iS,s.tEEonnpvvhiireroornnWmmeedensnt:taalHlaPPzrraoortteedcctEtiivooannluAAagtgeienoncncysy..anNNdoovRv.e. v11i77s,,e22d000S06i6t.:eM-MSepememcoiorfriaacnndTduhumemshttooalWWdaalflkkoeerrPeSSrmmfilituthhorfforrooocmtmanoatc Christopher Weis: Hazard Evaluations and Revised Site-Specific Threshold fo~" Peffluorooctanoate (ViPrFgiOnAiao.x C5; CAS #335-67-1i)n drinking water near the DuPont Washingion Works facility, West (PFOA or cg;.CAS #335-67-I) in drinking water near the DuPont Washington Works-faci)ity, West Virginia. U`UWS.aS.s.hEEinnngvvtiiorconanWmmoeernnkttsaalFPPcrroiottleeycct.tiiwogonunonAAvgwgeeeennpgcscyi.y..oNNnoodvv.e. 22n00f,, o2200r006c6,.eSSmDOeWWnAA/d11u4433p11oCCnoontns_seeonntst OOderpdrdsfer--d-DDuuePPoornntt : Washington Works Facility. www.epa.gov/.regi0n03/enforcement/dupont_order.pdf WTWRhhiTittheiSSSbS,,oAAdMMeaCCC,aallaaWffoatot,,dZZ, KKnoudkklSleeEanFyyeikkn,,tLLoTTn:WW2i0li0lll7aa.nnouGoeevsvata,a,tRRioDDnaZZlehPh,rF,OLLAHHeplefolfesaontut,,rMMeJJofSSitMryyinnacasr,e,sAAABBssLLociininaddtssetrrdoowmmi,,th JA`1RA3ll3tceT-rr1hee4iddb4o.MMdaaemmanumxi,asrCyyGWGlloaaonnddd,DDaenevdveelSlooEppFmmeeennnttotniin-n 2DD0aa0mm7s.sGaannedsdFtaFefemiomanlaaleleOPfOFffOsfpsAprriEinnxgg.p.oTTsoouxxrieiccooolflooMggiii,cc'caaelliSSsccAiieesnnsocceec.i99a66te((1d1)),w, ith 133-144. ``WWWoholilfft,,,CCC3],S, SSLEFEaeuF,netnaonlondn,B, JJDEEASSbcbchohtmmti.idd,2, 0AA0M7M. CDCeaavllaeaflfaot,,pmZZeKKnutukakllleeTnnoyyxiiikkc,,iXtXyoAAfBBprreyyraafnnlt,u,oJJroTTohhciitbbaoonddceeiaacunarxc,,iKdKP(PPDDFsOa,~A,)SSiSSn -the 6`W CC2DDh4--i1tI7e,M3MCo.ouSussLeeaauaff,teearrnCdCrBroosDsssFAFobosbstotee~rrLaa2nn0dd0RR7e.essDrtideccviteeel,oddGpreGms~teantattatiilooTnnaoalxlEiExcpxiotpysouosruferpsee.sr.fTTluoooxxriioccooolclotoaggniioccaiacll Science 95(2), acid (PFOA) in Seienc~ 95(2), the. 462::473..................................... AAtttsacchhmmeenntt- PPaagge7e7 ooff 77 , 22114455..00001177 STATE_02338907 STATE_02338907 Li#L1uA2,u3,2te)at lal.. 22000055.. PPhahnnaacolidrtemt~caeevvacallutmaottiiooknn oofifppeenfrflluueo,orrootoocctitaannocoiiccaacciiddiinntthhee mmoouusese.,TTooxxiiccoollooggiisstt ((AAbbssttrraacctt #1232) LaLScauiuenetctaeas,l,S22000@00)66,S.1EE0f-fff5ee1cc8tts.ooffppeecrfulourocr0ooccttaannooiice acciidd, eexxppoossuurree ddaur.idnnggpprreeggnnaannccyy iinntthheemmoouussee.. TTooxxiiccoollooggiiccaall Sciences 90(2)510~518. - " ' ' ' " " ' " ' LLparaouulCiCf,e,BrBaAtAibobbnboiotntt,,laiavnneddrsDDoCCfWWwoilolfld.f-.2y20p00e077b..uPPteenrrofltfuiPorPuoAooRrc-toanonucoliielaanmciiodcaieanc.ndadTWcWhieYYdT1o41r4,i,66c4o43l3otegriesattem(esnaubtiminnitddtuutcecmededdfppoeerecrtoshnxeiiss2oo0tmm0e7e. pmarnmonlumiafdelrSSatOOioTTnmmieneetelitiivnngeg)r).s. of wild-type but not PPARa-null mice. The Toxicologist (submitted for the 42007 LLbrooavnveclheeessldeeeattmasmalslo,.,n2~i02u00m606,:pCeCormofplmaoprraoarotacittivvaeneraraeetsseppo(onAnsPseFessOo)of.frTraoatxtssiacaonnlddomgmyici2e2ee0ee:xx2pp0oo3s-se2ed1d1(.to llinneeaacrf/bbrraanncchheedd,,lilinneeaarr,,oorr branched ammonium perfluorooctanoate (APFO~. Toxicology 220: 203-217. L(LAuubesbeikcbaeecekttta#ea2l,l5,522)00.0066,. EEvvaalluuaitioonn ooff ppeerrfflluuoorr0oooccitaannooiicc aacciidd iimmmmuunontootorxiciciittyy iinn aadduulltt mmiiccee:: TTooxxiiccoolJo0ggiisstt (Absttaet # 255). NPNeFewwOAJJeeirrnssDeeryyiDDnekepipanasgrttmWmaeetnnettorofaftEEPnnevvniinrroosnngmmreoenvntetsaW)laPPtrerorteoScuttpiopenl.yc220Ct00o0i6m6poDDarnnaryaf.f.tt pprreelliimmiinnaarryy HHeeaalltthh--bbaasseeddGGuuiiddaanncceeffoorr PFOA in Drilaking Water at Pennsgrove Water Supply Company. Ohmori , N Kudo, K Kalayama, Kawashima. 2005. Comparison of the toxicokinetcs between pOpeehrrmfflidooorriroocKcaa,rrbbNooxxyKylluiidccoaa,cdiKddss Kwwiaittthhayddaiimffffaee,rreeYnntt ccKaaarrwbboo~nnshccihhmaaaiin.n. el2en0ng0gt3hth... CTToooxm:~ipiccaoorllioosoggyyn 184:135-140. of the toxicokineties 184:135,140. between Olsen et al, 2003. PerfluorooctanesulfonaeandOther Fluorochemicalsi the Serum of American Red COrlossens Aedtuallt.,B2l0o0o3d. DPoenrofrluso.roEoncvtiarnoensuHfefaolntahtePearnsdpeOcth11e1r:F1l8u9o2r-o1~9h0e1m. icals in the Serum of American Red Olsenet al, 2004.QuanitativeEvaluationofPefluorooctunesu(lPfFOoSn)aatnedOtherFluorochemicals intheSerumofChildren. Journal of Childrea's Health 2:53.76. Olsen et al., 2004. Quantitative Evaluation ofPerfluorooctm'~esulfonate in the Serum of Children, Journal of Children's Health 2:53-76. (PFOS) and Other Flu0roehemieals OpOellrssfeelnnuocerttolhaeI,,xa22n00c00e55u.l. foEEnvvsaatleluu.aatt(iiooPnnFooSff)tthheae.nhhdaallfp.-elirifffleeoo((rf1lo1/o22c))toaofnfoeaetlleiim.miin(naPattFiioOonnA)oofffppreeofrmfllouohoruroomeoacctntaannsceessruuulmlff.oonnaFattLeeU((OPPRFFOOOSSS):)., IpInnettreefrlmnuaaottriiooohnnaealxl aSSnyemysuplofmosniupamteooon(nPFsFFllHuuiooSrr)iiunnaaanttmededdApAlelkrkfylyuOOorrrgogaoancnitictcmss oiinanttethhee(EPEnFvnOivriAroo)nnmmferonemntt,, TOXOL7. human serum. TOX017. FLUOROS: RoRyspoeeseannnMdbBiBP,P, BBADDR AAbnbbubloltomttti,,JcJeRRSeScxchphommsieiddd,, tRRoDDPZZeehhsRr,,TKKhPPeODTDaaasxsi,A,cCColJJoW. W goisloflfa(ansnuddbtCm2iLLtaeauud..f22o0r0t00h77e..2GG0ee0nn7eeppArnronofuiaflilnigSiliOnniTwwinligldd meting) type and PPARa meeting).. null mice .exposed to PFOA. The ToMcologist (submitted for the 2007 Annual SOT S1Sa0..2kassk,re,CCr;~u.RRmLLbeeoinoaornd,mMaMoaCrCfurludelllxek,epnno..es22u00rr00e66,.(TTswewerneutnmyt-ypf-efirifvvleeuyyoereaoarorlclotonangngioitatutudediionnarallPsstFtuuOddAyyo)offisseearruupmmolotytomanelircchphorololedesusttceetrriooollnreeplllatatenetdd PrPteorseaesne~tneatratutimioonnbaaitotmtthhaeer-kAAmemreroeirficceaaxnnpO.oOcsccuucrpueap(tasiteioornunamall HpHeeearaflllttuhhoCrCooononfefetearrnee0nnaccteee,,MoMraaPyyF22O00A0066)..in a polymer production plant, `TRTeaackkeaapcctsaoMMrsLL(aam,n5add)BBDDbAAybbbPboelor.tf.l22u0o00r07o7.o.cAAtccattniicvviaacttAiioconnidooaffnMMd oPuoescefauaunonrddoHsoHucutmmaeananenSPPueelrroofxxoiissnoomameetPPerrToolloiiffxeerirattcSoocrro-i-AlAeccnottciigevvsfiii9ttc5ee(dda1)l, 1R0108e8-ce-11p11t7o7.r.s (a, ~!fi, ) by Peffluorooctanoic Acid and :Perfluorooctane , SulfonateToxicolo.gi~,al ScienCes 95(1)~ cT"hThheaamyyieecrra,,lKK.. 22c0l0a00s22s.,EEnnivvniirrootnehmemeennnttaaatliWWoonoarlrkkiinnrggeGpGrorrootuupp::oPPneerrflbluuuoomirainnnsaitceddecxchpheoemsmiuciracelalss::toJJ.uusstteiiffniivcciaarttioioonnnmeffonr~tiainnlcclluuscsiihooennmoiofcftathlh.iiss hf oreglwgeporisppdfEWeGwCDoCrpdf chemical class in the national report on human ht tp:llwww.ew g.org/mp0rts/pfeworld/pdf/EWG_CDC.odf exposure to environmental chemicals. : AAtttacchhmaen.t-Ppaaggee 66 ooff 77 " ' 22114455..00001188 STATE_02338908 STATE_02338908 vMMe eemmooom Date: November 20, 2002 To: PomeFrom: Douglas Wetzstein pu Dave Douglas lot sk Amh nUni Helen Goeden, ilealth Risk A~sessment Unit ' Phone: (65 l) 2 ] 5-08.7,t BEA Subjec.t: Response to.Request for Health Based Values and interim Soil Reference Values metre apse en Toa rg OTT This merfiorandum is in response to a request by the Minnesota Pollution Control AgencY (08/21/02) for Health B.ased Values (HBV.s) and interim Soil Reference Values (SRVs) for perfluorooctanoic ' . acid (PFOA) and perfluorooctane stilfonate (PFOS).. . ~. frill import 3 Sd te There is limited published informhtion on the toxicity of PFOA and PFOS.- The MDH relied heavily . on readily available toxicity summary information provided by 3M, EPA and the West Virginia Department ofEngironmental Protectiono- After reviewing this information the MDH modified-the . RID and RfC values proposed by 3M. : ' " Health Based Values (HBVs) CChheemmicicaall CASH# PF~)A PFOS ." 3825-26-1 2795-39-3/ 1763-23-1 " " EnEdnpdopioinntt Liver Liver " Jom RRMIDD (mg/k~d) HBYV ~g/L 0.001 7 0.0002' ] - Soil Reference.Values (SRVs) CChheemmicicaall " ' CCAASSH# " - [EEnnddppooiinntt ' RRIIDD ((mmggA/kgg//dd)) P.FOA 3825-26-1 Liver 0.001 PFOS 2795~39-3/ Liver 0.0002 1763-23- t RRIfCC - ((mmgg/mm~)) 2E-5 2E-5 RReessiiddeennttiiaall 'IInndduussttrriiaall SSRRYV((m~k/ksg)) SSRRVV(Lm~e/gkOe~). 30 200 i5 . 40 'Toxicity Value Sources: See Attachment II. Based on information curr~tly available we feel that the above values will provide an adequaie level'ofprotecti.on Br from ~xposure to PFOA and PFOS in drinking water and direct exposure to PFOAor PFOS in soil; h0w.ever, thehi " CSL is a degree of uncertainty associated with the HBVs and SRVs,.and they should be considered pr6visional. The rtabove criteria do not address impactsto groundv~ater as a result of soil leaching., food chain impa.'c,ts or ec.ological . impa~ts~ =Please note that Carcinogenicity studiesin the rat have shown PFOA and PFOS to be potentiMly carcinogenic. However, at this time the available data are not sufficient to determine relevance to humans or for development of cancer potency " valu~is. . Environmental Health Division 121 E. 7~ Place, P.O. Box 64975, St. Paul, M]', 55164-0975 - (651) 215-0700 htto:!/www.health.state.ma.us 2114455..00001199 STATE_02338909 p"eTTrhhseeoddanawttaia tuihtflldizsiedn,kin_tthheew,addteecrrrivvitanitgiooesnntoiofoftnthhteee/H-IRoif3V2sHseipsrispoipvoevirdiddaeeydd,'iiannnAdAttataraceclhhimmveeennttso|I..urSSctaeanicadodnaatrrdiaabustssiuomnuopftiro20nsppoeofrtfcaen7i7t00wekokrilleoongugrsaasemmd - 10calle these values. . persoti witha d~kiiig wateringestion to calculate these values. rate of 2 liters per d~y, an~l a relative source cgntribution o f 20 percent wer~ u~ed t. hIMVeDI~sHHtaiinsdiiannrttdhhseesppurrm~opxcr:eei~sosonosffrroeefvvii,s7iin0ngKg.liito~sgHHreaeamallstthha-nRRdiiskk2LTLiiemisitt/s dfooryrbggerroroueunpndldwacwaeatedtrberyurl.ea.bTTohdheeyMMwDDeiIHghFits lailknelayydnttoOinrreseckoecmromtmeemnmdeohtnrheadtet the standard assumptions, of 70 kilograms and 2 liter'/day be replaced by a .body weight and an intake rate more aapfparcooprinoeffo31r0c4.hilden. (hi recommendstiois acceptedand promias le, HBVswould ikelydecesceby appropriate for children, Ifth!s recommendation is accepted and promulgated as rule, H~Vs would likely decrease a factor.of3 to 4. - "iTTshhkeeddvaaattlaavueuistliilpizzreeddeisinnetthnheedidenreirtivvhaeattiiMooPnnCooAfft'thhsee SSDRRrVaVkissiGsuppirdrooevvliiiddneeeddsiinnfoAArttttthaaecchhSmmoeeinnbtt-IHIL.oTmTahhneedHdeefefaaaululdltt eePxxapptohoswsuauryree,sscTceeecnnhsaniriicocssaalannSddupttaaprraggreettt Document (Working Dra January 1999)wer lized 0calulte these values. risk value~ presented in the MPCA's Draft Guidelines for thi:~ Soil-Human Health Doctimeat (Working l~aft, January 1999) were utilized to calculate these values. Pathway, Technical Support' `"TTwhhheeerM Me dDDeHgHr'sadaaauutttihhooonrriihttayysttosoippnrreooammdymuaollgcgcaauteerehId~e.ealltihSirimissikbirliyim,isttshuuennHddeBertSthheesGnGrdrooSuunRaddVwwaapifreeorvPPirdroeotdceccatirieoonnmeAAcnctdit eisd]mttrooitstceedrv0teosssiittuuisnatttiie0ornnizsm daawddehvvveiiercceleeodiipsesesgsuurfeaeodddaffthoioeorrnpsspphedacucsiJffairilccreosspfaiitd.tpeysorsoowwvcshihced~urierrnerge3ada.ccnooSunnpitlmpaaemimlraiinrlnlayan,ntothhhaeasI-dbb[OeeBgzeV~gnnasdddaaeetnttideeoccnStt.eeRddV.. s As such, p~'gvided As such, neither the HBV nor are inlended to'serve neither the I-[BVs nor SRV are as interim SRVs are developed for the purpose ofproviding an upper Iirait for degradat.ion. ccco:: ALLsaarreryyKGGuuuksstot,w,sMMkDsD,HHMDH, : . .J`JAiGimenmrnrKeKyeeKSllmluyi,kt,ohMMw,DDsMkHHDi, HMDH. ~ LSGShuheekerllerllyeeCyyShmaBBruiaptrerhmmn,taaMinne,D;r,MMHPMPCPCACA.A + -.LMLMaauuarkrryeyaCDDSyhoymlameorpomne,ndnd,Mt,ieFMMrC,IPMACCPAACA J1ML9oia~hculohircaahBeauSelltaeSSlaeaabmmnoot;l6rTMra,o,rF3CM3MMA, John Butenhoff, 3M EEnnvviirroonnmmeennttaall HHeeaaltlh DDiiviissioonn + 112211 EE..77~ PPlaacce,, PP..OO..BBooxx 644997755,, 5S.t Ppaauul,I,, MMINN,, S5S5116644.-00997755 +- ((6551I)) 221155-00770000 ipheassteo ns htrp://~,'w~.heahli.state.nm.us 22114455..00002200 t SSTTAATTEE__0022333388991100 AATTTTAACCHHMMEENNTT II DATA FOR DERIVATIONOF GROUND WATER HEALTH BASED VALUE (WY) DATA FOR DERIVATION OF GROUND WATER HEALTH BASED VALUE,(E[BV) C ocCamomsptop:ouunnddNNaammee:: CAS #: P3Pe8re2lr5ful.ou2ro6or-no1cotc(taOancntooaat1t6ee,((2PP0FF0O2OpAAe)r)son) communication with Dr. John Buicoholf, 3M) 3825-26-1 (Oct. 16, 2002 personal communication with E~r. John But'enhoff, 3M) LOAEL ingestion): LOAEL (ingestion): UncenFactor: Uncertainty Factor: RIM MoDoddi:iffyyiinngg Factor: Factor: RfD*: 3330mme0gk/(0kg3gi-/ddiaanytyerspecies; 10 inmaspecies;10subchronic to-chronic 10 ' 3000 1 LOAEL 1o-NOAEL) (3 - inter~pveies; 10 - inlraspecies; LOAEL-to-NOAEL) I0 subchro~ic-to-chronic;r 10 0001 0.001' mmggk/kggi/ddaayy HHeeaatlthh eeffffeecctt: LLiivveerr RelativeSourceContribution (RSC): 20% Relative Source Contribution (RSC): 20% OAOnprlpallSiSlelodoppFeeisFFkaaccLttoeorrv.:-e"l: NNNAAA Applied Risk Level: NA HHOBVY ==((RRIIfnDD..ammpKgha/akel~d/(d)2).L((RRpSeSCrC)da1(1y00/0T0000 k~ggt)~inmg~)) Intake Rate (2 L per day/70 kg) = = (0.00) (0.001 mme~fk0kze0/fd2))9(L00.i22g))i(al0b0O000 tt~gmine~)) == Twp 7 pg/L 0,029 L/kg/d DDaattaa1."SSoouurErccPe~eA: R" evised Draft Hazard Assssmet of Prfluoroactanoic Acid and ts Sals (Nov 4, 2002); 3221.... 3EEEPPPMAAALiDRDfrereaavtffiittsmeHHedaaDzDxraairrrnaddkftiAAnHssgsaseezWssaassrtm dmeeeArnnstHtseooeafsflstPPmheeerrAffnldltuvuooiorfrsoooPoorcccyrttafalftun~oooroiriPcoceorAAcfctciiaiuddnoorsaioan~oddcAtIIctassnideSSaaasllnuttldssf((oIFtnFsaeeStbbea22l(0t0As00p2(2r)Ni);l;o2v040,2)2;002); 43.. 45.. S333uM M bMchSLSrooiiofilenltiSSim cccxreTeeoeeDxnniriiicnnniggktGiyGuniSgutdiuW eddleiaileitnnseeerossHnffePooarerlrtPPhuFFoOAOroSSdovc((iM tsMoaaarnyyycs2f2uo00lr00fP22o)e)n;rsftlueoProotoacstasnieumSuSllftoniantCey(nAopmriol l2u00s2M);oa-keys. 5. 6. Subchronic Toxicity Studies on Perflu.orooctanesutfonate Potassium 3SeMacSaotiltaSclr.eeTonxicnigoGluoigdieclailnSecsifeonrcePsF6O8A24(9M.a2r6c4h,22000022);. and Seacat et al,, Toxciological Sciences 68:249-264, 2002; .and Salt in Cynomolgus Monkeys. 6. 3MSoil Scree~fingGuidelines for PFOA (March 2002).. n*oCatrascrucifinniocogigeeeniBtcificoittyy4sstquiudaienetsiitnnattthiheveesraatst shacavsvepeessnhhtoo.wwnnRPPeFFpOOrAAodttouobcbeeeccaaanrrdcciinndooeggveeenlniocic.p.meHHnootwawelevveeferfr,,etaostt,tihbissastiiemmdeeottnhheesatavuvadaiiiellsaabbilneedadatatstaasaarnreed rarnHabobabtbilsisutse,f,fooicoccfieceuun|rrtdafatoylreev)vaeeliqlsuhu haiinggthhietearnrttittvhh0eaahnlasddtsooesssedee sse~sgaccraeaeunua sts.iinnhgRge elvipfvereetourdstoueoiscxctaiicinviydety.na.enoHHdnoadtweeoevsveweloerw,prddmeuceeeexntpt0ooa1lsrvaaeeppdfif.ddeecleOtlysvii,marmbrianiasaas,enitidtoounnobiuninnlsafftreumhdeyiaeplesemarripansltasarsa((issltaseeharruenusmmds alsh~isalsnloocfb-ebleieefefeefnneocfootbb!sssdweeaerryvrv)eeedidtobiiinsnsueffrene~vcraelladele~estrtraottthssweaahlttaodtdwodoesessetg~sradeaeasstlohoeewwvfeaaatususs11te..d6s6)mam.nggdtkWknogyer,o/nddn(a(nntoedotsieoe:w: en4arteNNeOOaxpAAppoEEasLUerdwwf.oasO~hvannavotretiaGhdneeettteuscib:mmauileinanreeadhdcytffpoirervrttpshhleiiascs~receafftfehoecractyst msienccheaenfifesdmtstwhtereexoebssenrvtehde female a. at ttie lowest dose evaluated). Women. do not appear to have the same active secretory mechanism that exists in the f~male rat. Enviroment Division 121 B.7 lace,O.Box 64975, 1.Fa,MN, SS164.097 651) 215-0700 Envirorunental Healtfi Division 121 E. 7~ Place, P.O. Box 64975, St. Paul; lVIN, 55164-0975 (651) 215-0700 : hw bell ste us wy h.ttp://www.hea!th.state.nm.us ~ 3 22114455..00002211 SSTTAATTEE__0022333388991111 Cocamspho:undName: P2Pe7es9rff5ulu-s-3ro9oi'-no3coct(tapanonctesasuusllsffioouunmattes~a((lPtF)FFOOSS)) ., " (21107770669.3351---.6232,393---211300i((2fprrpoeeteeasssssaail)ult)m)cosmamlut)nic. ationwithD. Joh Buteshoff, 3M) (Oct. 16, 2002 personal commuriieation with Dr. John 13uterth~ff, 31v0 LUOin~NcOeEAnLEaLi(n(niyngFgaeecaittoioornn:):: Uncertainty Factor: R iMMopoddi ifyningg Facor: Factor: 001.1010550m.me0ng-ki/pkeigri/sndypaeycies 10 inspec; 10sbclenic-o-chroic:JLOAEtLo 1000 (3 - K1 OAEL) NOAEL) interspecies; 10 - intraspecies; 10 subchronic-to-chronie; 3 LOAEL-to. 00002 1 0.0002 mmpgi/kggi/adnayy Hest ft Liver Health effect: Liver ReluiveSource Cotrivetion (RSC) 10% Relative Source Contribution (RSC): 20% OAOnriaplSSpilopRlpeseFikFaaLcecettvooedrrl::. NNNAAA . Applied Risk Level: .NA HOY HBV (e (RRIfnnD,t.-moe_Rikaete Jd~(2CRLRSp8CCr)3d(0e1) oy0o/07o00u,k~pi)4~)) Intake Rate (2L per day/70 kg) = (0000e2g 02 100 fs) = 1p (0.0002 m~k~_.]d) (0.2k(lO_OO~Jmg} = 1 pg/L 0629 Chgis 0.029 L/kgtd Dat Sources: Data Sources: " ' I EPA Hazad Asscsment nd BoningDat on PcfluroctanSufonte PFOS (ly 2000); I) EPA Hazard Assessment and Biomoniloring Data on Perfluorooctane Sulfonate - PFOS (July 2000); 2) 30 Liftime Drinking Wc HeathAdvis foxPefluooctan sulfone (Apri 2000, 2) 3M Lifetime Drinking Water Health Advisory for Perfluoro~ct~ne ~ulfonate (April 2002); .' 3) 3M SoilSrcingGuidelinesforPFOS (May 2002) .3) 3M Soil Screening Guidelines for PFOS (l~lay 2002); 3 Subsonic Toxicy Studiean PrflorooPtcs anSaeltssCylnofmlgousmMontkeyes. Sacca - 4) Subchronic Toxicity Studieson Perf/uorooctanesulfonatePotassium. Salt in C'ynomolgus Monkeys. Seacat el a,Toncolgicl Sciences 65249.264,2002, nd ? . al., Toxciological Sciences 68:249-2(>4, 2002; and 5) 304 Comments on IntrspcicsUncertainRisk Assent fo PFOS. 5) 3M Comments on Imerspecies Uncertainty in Ri~k Assessment for.PFOS. "Cuioogmiciy sic in hr ave show PROS 1 becscnogenc. However his ime th sve dota re *Car~inogenicity studies in the rat have shown PFOS to be carcinogenic. However, al this time the a~;ailable dam are nol sufficient for quanta sscssncrt Reproducive snd development] eles, bis on studi in 3 nd noi sufficient for a quantitatwe assessmeiit, Reproductive and developmenial effe~ts, based "on "studies in rats and Fabs,occu at evel ighr han doses causing ne 0c rabbits, occur at levels higher than doses causing liver toxicity.. DePeporsMoeed: Noverhr 14,2002 Date (Prepared or Modified): November 14, 2002 Prepared by: H.Gosden Prepared by:. H. Goeden EavionHmesethnDtiviasioln + 121 67% Pisce, P.O.Dox 64975, St.Pal,MN, SSIG4-6510)2915.707500 Environmental Health Division * 121 E. Tn Ptace, P-O. Box 64975, St. Paul, MN, 55164-0975 o (651 ) 215-0700 epi esth i ne 4 httg://www.health.state.mn.us 4 22114455..00002222 STSTAATTEE_0022333388991122 cCCoaommspp:oouunnd4 NNaamme:e: CAS #: AATTTTAACCHHMMEENNTT iII DDAATTAA FFOORR DDEERRIIVVAATTIIOONNOOFFSSOOIILLRREEFFEERREENNCCEE VVAALLUUEE ((SSRRVV)) . P3P8ee2rr5ful.ou2ro6or-ao1cotc(taOancatooaat1t6ee,((2PP0FF2OOAAp)e)szonl cormicaton with Dr. John Buteshof, 34) ' 3825-26-1 (Oct. 16, 2002 personal commanication wi~ Dr. John Butenhoff, LULnOOceAArEEtaLLin(tgyesFtacitoonr):: Uncertainly Facto~ RDMMoo"ddtifyyinngg Fac: Factor: Rice P...I~*: 333mm0eg0k/kg0gi-/ddiaaiyyerspeces;10 nraspecies; 10subehroic-o conic 10 3000 1 LO1A0 NEOAELL) (3 - interspecies; 10-.intr~pecies; LOAEL-to-NOAEL) I 0'subchronic-to-chronic; 1O W00.00S0011 mmmgygm/kk'gp/dnayy 2E-5 mg/m~ DD~enmnsal AAbbssoorrppitoionn:: 10% (MPCA Default fo argasic compotads) 10% 0VIPCA Default for organic compounds) HHHaeeraasltth Qeeuffoffeetccitte::nt: Hazard Quotient: 0LL2iivve(errM-PCA target risk va) 0.2 (MPCA target risk value) OIOnnrhalallSaStllioooppneeUFFnaaicctttooRrir:c:k: + NNNAAA 'Inhalation Unit Risk: NA' IRRneedssuiisddtreeinnaitlisalSlRSSVRR:VV:: 2330000mmmgiktkkeg, lndus~al SRV: 200 mg/kg DDaataa1)SS"oouurEcrePcseA:: Revised Draft Hazard Asse-ssmeontf Perfluoroociaoie Acid arid Is Sats (Nov 4, 2002); '223I)))) EE3EPPPMAA~LDiRDfreraeavftftiitsmeHHedaaDzDzraairrranddfktiAAHnssgssacezWssaasertmdmeeerAnntsHtsoeto~flfsPlsPemseerelAfnldltuvvoooirrfsoooPooreecyrttfaaflnnuoorooiirPccoeoAArcfccl~iiuddhooraaionncoddcAtIIctatsinSdeSaalasltnutlsdsf((oIFtFnseeatbbSea22l(00tAs00p2(2)eN):l;qv2. 040,2)2,002); 3453)))) 33S3uM MMbcSLShooirifiolelntmSSicocarreTeeoeeDxnniriiicnnniggktiyGGnuSguit.idW udedelialieitaneseerossHnffeoPoarerlrtPPfhFRlAOuOcSdSrvc((oiM scMotaarayyynef22so00ur00l2Pf2)oe);n;raftlueoProoaoscstainuemSsuattfoinnatCey(nAopmroill2g0u0s2M};orleys. 5) 6) 3SSSeueMaabcccSaohatirloetntSaiaclolr..T,eeTTonoxoixixcncc.igiitooyGl!uoSoigtgdiuiecdclaaiilelnsSSeocscuiie{ePonnerccrPeetlssFu66oO38rAo2:24o(49cM.9taa-2r2n6c6e14hs,u,2l220f000o200n)22a,;;teaanPnddotassium Salt in , . Cynomolgus Monkeys. ` 6), 3M Soil Screening Guidelines for PFOA (March 2002). a** CCraarcrcciinnsouogfgfeeincniiicecinitttyyfosstrtuudd~iqieeuSsiiinnnthtiheaeirravtt ahhsaacvvseesmssehhaootww.nn PRPFeFOpOrAAodttouobcbeievccaaarrnccdiidnnaeogvgeeennlicoic.p.meHHnootwwaeelv~ef,reer,c,atasl,tihbsisismtcimdeeontthhdee iaavvcaaisillaaibbnlleeroddtasataa aaatnrnesdd.rnrasoabetbbrbsuiuimtsfsf,,ioNcocAicecIcnFuulrrfoattrollaefevqv|euedlaesanyhht)iiitgagillahieuvsrentthahcasanslcddseososmsefecossnchcla.aauustRsiienenpggroilndivvueecrrcthiotevovexfaiacetnittd.yu.dseHHvsneoodlwownpeeemvoveenrena;dttdraeoul,seweef1tfo0reecraatsppe,ixddbpaceoslsieimedmdaion.nnaOttsvioolaunnrdii1iane"nsffnieonmmlraaalltaees dhherayyttppeseenr(rmsppeil[ranausesmiiaafhhhoaaslstfs-halsiilsfsoeofbobfefeceeltnn-sdo.oiabnbyscs)eeerirtve.vi~eefdduiintnncflfeweemaemraraeltoloeebwrasahetasrtvaadtetedddgootrsseteeehss.teah~leollfwooeewwtusastasedsso11.sa6 .ntdmmevnggae/lok/ungadat/dtee(ds()nn."oweteW e:r:esaeNxNpo OodAsOeoEdnL.Am owOwtaEvasasaprnoe Lpiabatntrtfuon bhualvaer ~ dheetesrammienaecdtifovretsheicsr.eetfoferyctmseinccheaenfifectsthwaeereiotbsenrtvehde aftetmhaelelFowt.est dose > evaluated). Women do not appear to ha~e the same a~ive secretory mecfianism that exists in the female rat. ~ .. n**o**tTTchhoenersreidiisesriienndssuutlfoificobiee3ennvtto.liiuaftnoirlfme acothieosmnicooannlthhaeendttostxiiccaoohloggiiccateahlleecflfaeTcltsrcoioffnPtPFFeOOsxAApoffsoollelloopwwaiitnnhggwnianylhaiastlaiatoinoncneiexpxpapootsseuourdreeb.. PPFFmOOiAAnoiirss.. C.ppnaaaorttthih~cwnvoaganyYg.sei.dne33irMMeidnhhsaataonusibgsmeueagalsgsvteobseultaetdtdiwl3eaitPcRhh3IeUCkmonoifcfoa22wlE.an-n55demmeihgve/apmrne~cfoebbraeatsoetdhhdeuoominnnahnaasgel.aentnTioeehnrericeCxeeApxxoppTosoTussruurerereeppoaggtruuhtiiwddpeeallyieinniesen~fafooncrticrccahhipeRetammItieeiCccdaoadltlfoss bfLfoeIouaEnudmSnftidoonobbree ~amrgnaggr/c/meimn~r_oigTIennnnSiot~h,iheelisnaRbaehnsfeiemnercaeelnscoofbefiuniVntfafwoloruirmtmehaatutiniooknnnohthweenpprrreoolvveiivssaiioonnncaaell RIC sggesied by 3M willbe to humans. The CA'IT report R_fC suggested by 3M will be iid forthe generated a utilized for development Ra~ of 1. IE-3 the development of of - an interim Soil Reference Value. s 22114455..00002233 SSTTAATTEE__0022333388991133 CocCamomsppoouunnddNNaammee:: CAS #: . LU' OLnOAceEArLEsLn(ti(yinnggeFseatsictiotonon)r)::: Un.certain~ Factor: RDMo"difying Factor: Modifying Factor: Rice: DDeerrmmaall AAbbssoorrppttiioonn:: HeHaelatlthh eeffffeecctt: HHaazzaarrddQQuuioteienn:t: InOOknroaillaSStiliopopneeUnFFiaatcctReoirr::sk: Inhalation Unit Risk: 2PP7ee9rri5l-uu3oo9rr-oo3oeo(tcpaontteaasnuslesfisounumaltsefa(lo(PtPn)FFaOtOSe)) . .2(1107677.19666,533---322339---211300(((2fprroeepteeearssssosaanilalutl))mcosmamlut)nication wthDr. JobaButchoff 3M) (Oct. ,16, 2002 personal corrmaunieation with Dr. John But~ahoff,. 3M) 010.0.110550mm(y3gki/ekntlge]drdsaapyyecies; 10 naspecies; 10sut0-b<hrocnic;h3LiOABoL 4n0-NiOAFcL). . 11000 (3 : interspecids; IO- intraspecies; 10 subchronic-to-chronic; 3 LOAEL~to-NOAEL) 001 .00000022. mmpgk/gkig/ddaayy , ' 5my' 2E-5 mg/ma 1100%% ((MMPPCCAA DDeeffaauulltt ffoorroorrggaanniiccccoommppo~uunuddss)) LLiviveerr - 00.22 ( (MPCMAttaarP rggeettrrC iisskkvvaA alluuee)) ? NANA ..- NANA ReRTsnieddsuiedsneithaitlaiaSllRSYSR:RVV:: 4066mmmighk/keg Industrial SRV: 40 mg/kg DDaastaDaSStoouurSrcoseus:r:ces: 2Dl1))),ataIEESMPPoAALuiHrfHcueeatsaz:iasmrdedDArAissnsskeeisssnmmgeenWntatatanneddrHBBeiisoohmmtohonAnidi"otovrriiinnrggyDDfaatotaaoPonenfPPlrecrfrfllouuocecrrtooaocncctaasnnueelfSSolnuafltfooennsa(tAteepr-i.PlPFF2O0O0SS2;((JJuullyy22000000));; 2343)))).. S333uMMbMcShLSovioioflielnStiSirmcccreTeeoeDnnniiricninniggtkGyGiuSnitugduiW eddlieiaelintsneeersosmHffPeoora~lPetPhRFOArOSdSf(v(iMMsloaaryyyu2f2o00or0022P)r)e,;rfoluPooorotocacststainueamSsulnltfocinnatsCey(uAmopfmriolo2l0gn0s2M)ao; ntkeyes:Seacetf 4) 5) o3Sal,lMu.,TbCTcoohosmrxcomeinieloicnlootTggsioiocxcainlcliSStyc.e~iSsieetpnuncedeeceisesis.6e68ogs:n:U22n4P4c9e9e-r-r2f'2tl6u6a4o4i,n,rot22yo00c00il2n2a;R;nieaacsnnukddlAfosnseatsesPmaernats:fstourrnPSFOalSt.in Cynomolgus MonkEys: Seacat et 5) 3M Comments on Interspecies Ur~eertainty in Risk Assessment for PFOS. .n"*oCCtaarsrcucifinfnoiocggieeenntidtccifittoyyr3sstuuqdduiaiencstiiitnnattthhieveeraatatshshaeasvvseemessnhhtoo.swennRePPpFIr:OOoSdSutctootbibeveeccaaarnrccdiinndooeggveeennlicioc.p.mHeHonwotewalveevfree,rc,ttasti,thbsiaststienmdeoe ntthheesaavtvaaiuilladabbilnleereddasaatasaaintcde rabbits, occara vel higher handosecausing liver (oxic. not sufficient for a quantitative assessme.nto Reproductiv~ and rabbits, occur at levels higher than doses.causing liver toxicity. developmental effe~ts,based on studies in rats and `#c**o*TnThsheierdree~r'jeissditinnouabuleffafiivccoiileanrtittiilinnecffoohrremmmaiatctiiaoonlnoaonnn"dttthhheeetroteoxfxiocircoeoltloohggeiiccmaalhlafelffafctetocnstseooxffpoPPsRFuOOrSSefpofaolllllloowwwaiyiinnggsiinlnchhiaapllaaittiioenndeExtpoxopbsoeusruaemre.i.nPPoRFrOOaStSibisvsannyoo.tt a3c3goMMennssseuiudrggeiggrceeeesdsxttpteeooddsbaaueRrRaeCfvCiossldaootfiefl2e26nEc.h-4~efomaarcninchddae2!2m.Eain25cd5altmheseg/frie'aom_u'f~onfrfdoeootrhbPPeeFFicnOOahSScailaaannntoiddognPPeFFneOxOipAcAQ,i,nrsreuaesrnscpipepmceaatctilthivsvwebelaulyyyt..wisiTTlahhhneeutivncvaikalpulnaueoteewfdfonotroePPblFFeeOOvaaAmnwciwnaeoastrsobphbaauastmsheeawddnasooynn. .PaPInRFgtOOehnSeSea,ar~bippcsppeeeenxaacprressotostooufbrbieeengc.fcdaoairrdrccmeiialn~ntonoigegoeenfnontirchcneihnpe.ramartiscobabalustvtfiiottiuisRnmsndoCoitttocfcloobeleearnacPrawwaFrhcOehiltenAhtoheg(ere2rnEssi-uuc5ggigenmesaystnteneimdd)ammlessecucbhghuagatnenwisitssitemmhdouobfnfyakacc3nttioMioo~nn'wniiilrselr|lbeevlee~vvmawanicniietzttoOoedhhhfuuuommmrataannhnsses_.. { development of a inter Sil Reference Value for PFOS 3 'In the absence Of information the provisional. P,.fC for PFOA development of an interim Soil Reference Value for PFOS as well.(2E-5 well. mg!m~) suggested'by 3M will be utilized for the DaDPtraeisep((aPrersepbcpaydar.reei1dt.ooGnrMoMsododediniffie)d:):NNoovveemmbbeerr1t44,,22000020 P~epa~ed by: 1t. Goeden ' 6 22114455..00002244 i | SSTTAATTEE__0022333388991144