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*! AAaMrfi V*4 IM. IM P*t 364 mg * TW hs*d a the < M d tfWw l||!MI< nuwi w iM TW WWaUiUn at I f l/d*y (or 1 bo daJ> fte I *4 sXmj b> WjeirW rifta a --i--ah The up iaaw lunnii tW BfiWu at mnu^amtc at tW nrlur imH u I dstcaas i ik hnmas ms wtanre a harterwl mfwtidt W the akm nl* liMk V Is l.v TW BWUCSBK atiMty at unat >IU from a h the penda W Mtw [Ml M-4!iad nan xamtial pvuf at I* BIWW mat Iraaiad wnk I am )6% Hsrgii martinas The bog-term ] awt wla( a'I rsnras a 1/ IM Iflloi lull luul la nnntlml npiwi U risyl the ear ni^mu ri>ut>i m the pa hnl * (kTM4 ffcod a lab V fHiHii. Cxyt. Rd^rd, Zudon. ZWm <LW*t DsW Vadsl. SumI. Idnr. Prato,, CWdO. Pro, U* im. SMI). l- (Csdi) 104. 192112* (nlnatha ef mmi1*1 r*4*i *tp*Hr fra Omipstins.l IHMIII Is tamyl rhtan4r (I) (7S-*I-d] ui pUstic* 4nai>w ef fiiatfia sheasbate degsetM. tjcKKo^t, G C. ptui wkmI pLyul sod ptydtol ptublw rwjhinc in > dsstli nu Ajibnlf. J P . Skowrasii, M G (Nisei Em Heahb Phys TM two S1S% k%Wr Ihnn normal and a Kuodt rata 23% Program. Georgia Inm Technol. Atlanta, CA 1>*A) Mi* Eng kt|Wr thaa asrmal. TW WdHMio, turnon mart predominantly ilAtlieton Colo t |)ti, 3R3), 196-4 (Eag) A mcdil was dwit^rtl fastroutntmal and mapirstofy Duns, 10 yr. STS tsploym diad at to cak ibe potentul radtokg maagwafti from dvwkpifcq tW r, at* of SJ..S. thaw av axposurt to I *sa II S yr Eipaaurt at l'-cunt* phosphate ruck* a 2 Mte* m Georgia fa tperse-k populated 22S Borfcat, to I for an ,v at 17.1 yr tauaad akin diiimn 21 3. re*. EC'i sad a kU & mi southwiwt of Sarsfeaah CHI). Mu. carditnwular duturhanrm l&S. and pyrhiatnr dbordan S.S%. occwpetMMial ripuun far Ra at EC2 would be 1-2 Him (workMg Expoaun to I ramad apontanaous abortion in >J% af 418 pr*(nant level mol The pT^Htl+tina den* for the cuuairy at this utr ( * 2 mi w%--n. froM tW mum) was aotd n 2 v 10 '* MX or effectively 0 The cakd 104 192I7tr DeterminatWa ef N-Methylferazamlde la arlne Ro diorkrt ran sc GHl war ^0 l WL Ra cmcs. at Savannah by gas ck-rsmaUfraphy, Cechova-Wicarova. Olg* (Lek. Fsk., ana ill & x |0 pfi L (or effectively 01 IJEP, Brno. Caeck) fine Uk 1981, 37(10), 38844-8` (Czec'h). 104. milk Pi rantht af ekakJ pnoetitf ctakiag by TW urine of workerz exposed daily to NJt-dimethylformamtdt (I) three Wm ry --but aixtvm. Mickbrn, R L, Roder. M M_; [44-12-2] contains vt* metabolitet NS-mt*tihhyiformnmidr (III [124-99-7] ia*tk S P (Dr* SmS Ru. Natl Inet. Ocnjp Saf Health, a* well as the unchanged I To analyze u< rine in I exposure studies, a lun WY J6505-2888 USA) Am /ad H\g Assoc J 1989, modified gaa chromatog method (0. Wicarova, 1990) was used with 234-40 (Eng), TW permeation of binary mixta, of common .V'mrthyiacetajnide as the internal std- In the 14-11 coocn. range of ml soKest* through glove matcnak waa lugher than that of 0-1575 X 10 * smoie/mL, the chromatog, response was linear and unfit--comjxxkent wjvtttu and could not W predicted from thWe relative detn- error waa 3%. psrmealsoc rataa of thr pure componmU- 104 192171s Ceweik Hak efoccapatlemal exposure fa iacremd 104 192144s Trace WMti af adtli ia fWad af workers acfentral rat leas ef polyckloriaated biphenyls. Hols, Nora, lk Bthhalew indaetrial W|d. Adtmsfcs-Dvmcwxkx, HalmRse,znicek, Jan (Krajsk* Hyg Sun., Usti mid Lebem, Czech ), fine Tmja-n-ifci. Barbara, Rornek, Stanklaw; Bala, Taoeusx; KowakrLyekk. 1984, 37(10), 388-91 (Czech) Exposure to polychlorinated Lucyim KoatUx, Graiyna iZakL Farmakoi Kim,, Wojak ALad biphenyb (PCB) in s pUnt where gravel was coated with hot asphalt MciL. Ludx, Pol). Bromatol Chem Tokeykot 1964, 16(4), 246-50 caused increased levels of aberrant celk in peripheral lymphocytes. (Pol). Trace amU- of Cu, Zn. Mu, Fa, Cd. and Pb waa deld in a In s group of PCB-expoeed workers, 2 87% had aDove-norm*) ms. of group of workers employed in the Belchalow Industrial Region. aberrant cells, at compared to 2.04% in s control group: in Poland, before startup of the eke power station and the results were severely-exposed workers, this value was 3 14%. The levels of tempered with Una* obtained from another cd aubfecta-inhebtuntt omcoHuc aeid [49-41-7], chole*trrr>l [47-44-41, and ^'lipoproteins of Lodi. All aobjecU under investasHoe wr re comperabl* in reapect in blood serum were correlated with the levels tit PCB in the Blood of of afe and arx, and were not yet occupationally exposed to metals exposed workers.. TW mean concna of Wood Cd and serum Cu m workers employed in 104. !92l72t Determiaatio* af mercapturates la urine. Medio, tW Bekbatow industrial Reftort were s*">>l*r to those measured m Zdenek; Simova, Maria; Kubiskuva, Botena, Svobodova, Pavla mhabttanu of Lodz- Serum Za coacn. was hifher than those in (Krajsks Hyg Stan., KUNZ. Czech.), Pne Lek 1944, 37(9), urban population, and serum Mn and Fe concns, ewre lower This 329-32 (Czech). Occupational exposure to vinyl chloride [74-91-4] discrepancy might depend on different living and environmental increased the eonen. of mercapturates in urine of 101 factory workers condrlsoaa, as well as on the extent tit ak. consumption among the to 38-55 4 Mmole SH/mmoie creatinine (max. allowable concn. 36.8 subjects under iaveat^auon. Raauhs obtained constitute the initial fimole SH). The anal, method for the detn. of mercapturatee data for the proepectivr appraisal of the environmental influence of involved removal of amphoteric disulfides by ion exchange, removal Bekbatow Industrial Region on Wood trace levels of metals in of other interfering sulfidet by redft with NaBH4 (with cor for subjects employed in this region. produced thiols), color reaction with EUmen * reagent, and spectro ICM: 192144c Aeeseennt tit tW eccopatioaal risk amoeg workers photometry at 412 nm. Model expts. with S-2-h\droxyethyl-S-- agafif la tW pradwetWa af dJriiyl-etyreae rubber, Stamova. oeetylesttetn* (I) 114999-24-1] showed that 87-87.6% of the added N4 Spesovskj. M ; Mukhtarova, M . Khhsteva, V,, Gincheva, N.; I was aetd with 4^o.3% relative dewstioo- Ivanova, S,, Kirkov. V., Pernov, K.; Panova, Z , Khmkova, L. 104 I92l74u Tea-yssr study af mortality af workers expand (Buk ). Probi Kkig 1944, 9, 94-106 (Russ) The working to carbon disulfide. Balesrova, Olgs. Svestka, Bedrich; Svsndovs, coooHsot-- are characterized in a SBR factory. CsH [71-43-2], Evs (Inst. Daki Vzdel. Lek Farm., Czech.) Pne Lek 1944, 37(7), eryrene JI99-42-I], and burodiene [194-99-4] are the moat 256-61 (Czech). The mortality rate in a group of 251 workerz weighted detrimental factors in this factory. The health condition of exposed to CSi in a rayon factory was 5.2% w 1.6% in a control the warken is given ns well as recomiDenaitioni for improvement of group of 124 persons, but all the deceased were above the death the working conditions, expectancy age for Czechoslovakia. More cases of myocardial infarct, 104. I92le4 laflwewce ef earnslet* aacWaare ea liquid pool changes in ECG. chronic bronchitis, and vascular problems were Area, Talem, P. A., Williams, F. W., Ndubixu. C. C.. Rsmaker, D encountered in the exposed group than in the non-exposed group. E, (Combust Fuels Branch, Nav Res Lab., Washington, DC USA) 104. 192l74v Vasospastic teadeacy sad RayasimTs pheasmaaap Combust Sri Technoi 1994, 45(3-4), 145-98 (Eng). This work la smelter workers expand t* ereemk. Lagerkvisi, Birgitta; advances the area of zone modeling by the development of a 5-ione Linderholm, Haakan; Nordberg, Gunnar F (Dep Clin. Physiol, theor. mode! with time-incrementing capabilities to predict the Univ Umet, S-901 87 Umea, Swod ). fnitron Res 1999. 39(2), reeufta of bq pool MeOH [47-44-11 flraa in a gas-tight enclosure. 485-74 (Eng). The eystolk blood pressure was measured in the TW model cons--ts of a bq. pool fuel bed. a developed flame above finger after local cooling in 47 workerz from a Cu smelter who were tW fuel bsd, s plums oe top at the flame, the enclosure walk, and an habitually exposed to moderate amta, of As dust The controls were ambient gastoui medium between the enclosure walls and tW 44 workers not exposed to As. The concn of moeg As including its fume boundariea It asinm-- a temp -dependent chem. equil metabolites in unne was detd A difference was found between the combuetkoo products and evapd. ft--I in the flam# It At-exposed workers and the controb in the finger systolic pressure at atm the energy feedback within each defined zone and skin temps at 10* and/or 15* expressed es a percentage of tbs 1 team*, (ammetit gas, flame, and plume), the maas tvapn. pressure at 30* (FSP%) and prevalence of Raynaud s phenomenon. rate of the fuoC the total pressure, and the 0 concn within the A low FSP% was taken to indicate vasospastic tendency. There waa ndoatara. 11- early effects of 0 coocn. on a confined MeOH Are are a covariation between the duration or exposure to As and the wag aKzhttzWd ia this work through a companaoe with an open decrease in finger systolic pressure between the measurements at 30 IdeOH Art modal Initially. tW rising ambient gas temp, cause* the and 10*. The uptake of Ax it the time of the study probably did not maas reap*, fate of tW fool to inmill. Event*--ily, the dropping 0 exceed 200 sf/dey. This was confirmed by aata. of the urinary wifi, rwduem tW mass evapn. rate through Ks influence oa the excretion. The av. total As uptake was atid. to be '-f g over 23 yr, mass air entrainment rate and tW flame Wight. There is no which Is lass than the total uptake of 90 g ef A* by subjects who evidence m the regkm of the mai burning rate for the influence cd developed black foot Hiassit Increased vasospastic reactivity bt the ,,T*'.,trhK^r,'r.r corcNjtK>n fthr* n and Revnaudi phenomenon in smettrf workers seems to be ASI 00004790 4 1 '*4 * **' Hi V.4 im hi WI mf, . <i imJ Bktb lN\ **m1 Jrv>4V Bl* 4lta-.*yi > i. t*r* alt.lt |j( Ik* *v*Wa*ul** w*Wtd l*> Mletwl NmKI ui Ik* . Mftin iM U4)MluA l`*4 !4AiU> UfctLftiwa *titi Md> -- r*U 9%p**m u muiiiH MwkWiif f*t It! I** k P k*li\ h r w tinmki P Ik . TttftkteJ***. H J *4'*nr Kn IWi I W}> E | Ik kl 4 \|HiUk Akd <`u , Ilk . \rt*fk t*! i*`M l \V T***`i-4 Appt 4%+fma* *4 IM, A.'k|i, k> i Eivg` H*u **t u lk U ktdh^M* k#ukk~U k> iwhaUth* si ftr*^4 itifttiu tW u, 0 \ l u, Jui 10 *4 m U* ti fc <!' ' dsv* aft (4 - it TWtr w#h *> aWawm*) ilm tsgiu.. kl> at , hatfttfv* *4 tkiVH fferftabl) U M tftlSWPd gtyVifft No fv*ih.i ck*t^n lAhrf tte* ft kukt rhian* w*f uted al U l Mg Ik' Ai 1 0 iuft m (hr hwrid**** u4 wiki rfcmit* awd tracheitis ** 4aa,rrM-d The liiito hk<*tt,i BAkf dv^l laden hoffi^A^f tduM *rli' rr# t* aith via hi Tvp* llpn**uw*-\'U kvprfpU*ift in ah*tli ad^'vnt ( thr ai\w4*< dvU TW puim*u4r> tnpiu^ it the 1 U mg is ^afk'fit-d i kt hw.J rniAnft fur mmaftrr dvt At to mg m \ rtf*pviiw'i.#v*/\ pa/tutr drptwmu* urtumd in the lfafh*uktfu*rhiai hmpn ihiW liver. And Hiktk wilh*Mj( nit) Mato* it(MW An ifc reaped irwiderwr *4 rhuuiM. tr** WlU*. and dust cell respuof kith T\pf I! pnfruOHK\te hvperpUi* btufttchsuiaftfaMufi. (may <kkt itII *fumul*imi, nhwular pnHeimwi*, chnfcalertd graftukiMML and Kval pkurwv b^ tk, Thr pul^uttkry fcpMoftft drv*k)0*d *n thr fthn.4*f dwi rtg^kt hrrr du*t rrlk hftd AC-ruBviiftlrd And ted pr>Ai,4rd 1'hMHK iHw tvtpmt In iddn-, (nr mvUdiffrrMtiitld, r\>tic krtfttinijtng v4}uit.ki tkfctfktew **r drvrhiprd from aK'auIi hh%wfting bn** hft>Uri4*ih*i with iqmiinw mrtaplmft ui tht aKwuUt dmi r*fn>n \i> lanuf mn !! tv fouftd k othrt arfkiUL Thr tang tutDikt- rtr uni^j* is'pr of rtptl inducftd tumur ted htd out hrm ftM-n iteutiK in m+n or numh Ttortfotv. thr rrk^tee* to but <>4 th*> upr 4 lung tumrw highi\ qur*tionfthk. h>4 ttliJi* PrrdM-i^w *f hteftkk 'lwMr *l! chw*rtelUrhy w4mc thr ftirtrr rhrriteTfd rnkuir um>. Drrn, Urtuu* F; KhkIjiII Laura K., Marion, Uwnirt J . Toiilcm. Philip J. (Srh. Mrd . I n<v I'ftltfiirmft. Ste Frr(-ft(v. CA 94143 I'SAi (nctr Re DM, 4*^` 4, Pi li 1W1*402 i Fngi Thr utrt chromaltd rirtunct iSTF* im\ ws u*rd to prrdirt thr chmmnrriwtmty to l,3-bi\2- - . h i>>ry>rtH \ i i i Bir^iwronn [IS4'M'A] of various oropUfttic rrl) vukpiip<jlftOtnv m ^ crU Uort drnvrd from human bram tumor. Hr^ftiar thr >C'hl any i ha*rd on anal of u>div>dual crlk. data obtained can be plotted a* Irequrno' htto^v^ of SCE, chromoaomr. and the range uf chrmoarnaitivitiaa of cell auhpupulationft can hr ldmtifird eail\ The SCE ftaaay has pfrdictivr value a> a cliQ away fur drug> for which ft iircma rorrrUtKw between ceU kill end induriMwi of SCE ha* been rfttabiiahMl. I*i4 143314a Mare tkaa addHWe taiiclty af the combiaatlte ( l-methy i-1 -altr--area plw> l^MafZ-cklwrw^kyh-l-aHrwaauraa ia tW rat. Zeller. W J . Berger. M H Henoe. T. Weber. E. In.vt Totirol Chemother. German Cancer Rea. Cent.. D-6900 Hodrlhrit Fed Rep GerJ. Cancer Rea ItM, 46^4, Pt lh 1714- If lEngi TW oantanauan touevrv index of l-mrth\l-l-rutiwum (4k4>93>S) plu l.J-hil2-f(i/omrt(iv/i' I -nitrxteoufra [lU-U-%] detd in the rat wm 0.32 TTu* overaddiuve combination toxicity appears marnl\ to be due to tevefe dam^e of the intestinal mucosa a* diagiKMed b> hatol examn and to damage of plunpotent tem celh in the bunc marrow at iiifiird by the spleen colooi technique. The molar ratio tif J-methvl-l-nitmaourea to l,3-bi*<2-chott)elhyl!- = 1-mtruftourea muhing in max mortality was 6- Concixnttantly measured UNA interxtrand crcwrlinking in bone marrow ctlli reseaied a dight mcreaae in DNA intemrand croaftiinking following both drugs compared lo l^-btfti2-chlofoethy!l-] -nitmeourea alone 104 143313b Owceweak reepease #f etraia A/J mice U ia haled cWmleala. Adkins. Bernard. Jr.; Van Slee. Elhard W'.; Simmons, Jane Ellen. Euitis. Scot L. (Northrop Ser\., Inc., Research Triangle vfc. Park. NC 27709 L'SAi J Toncoi Envtron Health 1944, 17(2-31, 311-22 (Engl Strain A, J mke were exposed by mhalatroo for 6 h da\, 5 day wh, for 6 ido to CS^ (7&--IS--#1. U-dtbromoeth&ne [lM'93-4]. ethsUne ondr J7HN4], naphthalene [91-34*3]. N'Oj. or tmW chUnd* [73-41-4]. Significant increase* in pulmonary adenoma formation were obad following exposure to 300 ppm CSi; 20 and 5o ppm 1.2-dihromoelhane; 70 and 200 ppm ethylene oxide; 10 ppm NO., and .Vi, 200, and 500 ppm vinyl chloride compared to Jf'Acontrol amtnah Expowure of mice to 30 ppm naphthalene did not licit adenoma Hiatopathol. examn. of lungs from is these tudic repealed multiple alveolar adenoma* Time result* provide hfuJrTUppwrne'fdiinctfoinrgmoanticoongefonirc the validation of this in vivo model potential following chetn. exposure as a tool T-y .^, 143514c Effects af benzidine on acme phwpbohydrelaaee tissues. Kochhar. Rachhmi, Sharmft, Rajaahwar; Dani, H. M. Oiha, S (Dep Biochem.. Pan)ab I'niv., Chandigarh, 160014 India! Re* Ball Punjab L'rui . Sci 1995, 36(3-4). 295-7 (Ena). Benzidine [92-87-5] <120 me kg i p ) affected the activities of alk pht/Mphatasc [9441-74-9] ana acid phoaphata*e [9441-77-4] in rat intestine, kidney, and liver. The activities of glueoae-6-phoapheta*e f94!-39-2] and fnjctnae-I,S-dipho*phatate [9441-42-9] were below normal in the liver. The resuH* indicated a gross disturbance in phosphate metab and fioconaagenests. These changes occurred early (1 and 10 days) after the benzidine administration. The relation of the changes to benzidine carcinogenicity alt discussed. 104 1135174 Extended eerreUtlea ef bend reactivity index wHh carclBogrekhy *ed metabolism ef pelycyetk bydreearbeem a make pier erbRaf t beery. Mohammed, S Nour (Dep Pbys. Meteofol., Indian Inal. Technvl., Kharagpur, 721 392 India). Indian J Btochem Biophyt 19*4, 23(1), 45-51 (Eng) Based on rmuha obtained from a reactivity index E(X.Y). atumpu have been made lu predul relative iar<tikgr(i*m anU mriaUJn < (*.*ii.*n M,-iU^,< w^uftiwr ot itewial depend* on Ihr drgre*- < ui>io 4 p^r.phefftl and tbw wyientt w en< efluin* unir* (h* (tmipd rihdot^ bj*M upliflSuftM utirih*w sIwtrupbiiKiU < s(M>n mn predated >ei th* has** uf I.1UO charge dwirihuUm* *ft*+ eel) nh rt->uiu (/m km regioa IkeKy and fftna eftpi* Hirdui#-d dttri)Mjn.*n *f metabi4ile and feUtu* carcinigeoa H \ r sU-* m lira- eith data fur thr quaetitis* 11>4 14351 be Wetaltegi1 iraeafer af reeditmised et banal aversion frsm elfaetlea ta UgasUsa depead* e Ibe uaceedktieard atimtslqa, hefWatka. Joseph. Molma. Juan ( . Niiear. N>*rman E ll mv ('ant Hingkamuxi, lilalr l on \t N<rk Minghamptrn. N\ l.Mul ISA) Behai Staral H*oi 1944, 4VI,. 57 To ihng, WeanUag i21 day *4d) rats were ripoved to KM)H [44 )7-4] i*ir paired with an interoceptive iap<imt>rphint indmed illnes*) or extenw'eptise tfooUhock induced at*ir*w*t rrmforipf Tw^ntx four hour* later. E(0H preference* were mtitured in a k^ation*! olfartuf) tewt (ElOH w Irmon odor) or an im;i'*o.,n twi i /6'l ElOH vs- 0.251 w4-,mJ citric acid **Jn i Ueanlmg rat* txpreMrd substantial olfactory aversion*, independent of the reinforrer empkned in runditMtfitng During the drinking U*f btfwever. t*o)i rat* that had experienced the r.tOH <* paired wiih interns! showed a significant redn. in the intake of the Ei()H 4n when compared u> unpaired control* Furthermore, rai> that had experienced the EtOH i^or paired with external dutres* drank significantly more of the EtOn soln than their control* These result* provide further evidence that olfactory experiences with EtOH can lead to charges in EtOH inge*te*n. and indicate that the nature uf the unconditioned stimulus u ml in establishing the ingesiive effect. 104. I43519f Acetaldehyde may mediate rrlaforcement aad averslaa preduced by ethane!. An examinatiea using a caadiliaaad taste-aversian pai^digm. Aragon, (' M G; AKiil*>l. Muriel, Amit. Z (Cent. Stud Behav. Neurobil, r<*io>rdia l m\ , Montreal, PQ Can. H3G lMbi. SeurupharmaeiAugs I9H4, 2f>Mi, 79-83 (Eng) Water-deprived rau were exp<iMKJ to ArH [75-07-4). EtOH [44-17-5] or vehiclr control. On the conditn^ning da\, the ammaU were first presented with a *>ln of sacihann after which the animals that were exposed AcH received EtOH and tho*e expend to EtOH received AcH. Saccharin wa* again presented <>n t more occasions (testing da>s) wiih<Hit infection of drug l\mg the percentage change in saccharin cunsumed from the fir*t prrsenuti(>r aa measure of version, it vsi found that exposure to ArH blocked the taale ftvenioo conditioned b> EtOH Animal* exposed to EtOH showed no aversion to the saccharin which *** paired with a small duse of AcH. indicating a tym relation between EtOH and AcH at this dose. However, exposure with ElOH did not block the i\er*n.n produced by conditioning with larger doses of AcH These result* suggest that the mechanism underlying the smaller dot* of the late aversion conditioned with AcH may he central while the mechanism underlying the larger dose is probabh peripheral 104. 143524x HydreryUtiaa sf acetone by ethanol- aad ace- Itfte-lifxdkk cytacbrome P 4S4 ia liver microaomes aad rvcoastituiod rnembmaea. Johansson, Inger. Rlia&v>n, Enk, Norsten. Carina; Ingelman-Sundberg, Magnus (Dep Physiol Chem., Karolmska Inal., -104 01 Stockholm, Swed ) FEHS Lett 1984, 196(1), 59-64 (Eng). Me/?0 [67-44-1] oxidn in rat liver micraeomes waa induced 5- or 8-fold by the treatment of the animals w'lth EtOH [44-17-5] or Me.-TO, resp The apparent Km uf the reaction wax 0.9 ruM. a value lower than the omen, reported for plasma MtX?0 under starv-atum condition* The ma>or Me/'O metabolite wax aeetol [114-44-4] MesCO oxidn in fmerf^eome^ was inhibited b\ typical cytochrome p 4$(t [9035-51-21 inhibitor- as sell as by compos (eg. untdaiolel known p> interact with tne EtOH mdur^^tle P 450 form Antibodies against this P 450 uozvme were inhibitory for the reaction in rabbit liver microtomes and this enzyme wa* the only one that showed MeiCO hydroxytation activity in reconstituted membranes Imidazole inhibited the conversion of p^TIMe.ro into low-mo] wt compda, (*,g, f/ucfe [54-94-7]) in vivo. The EtOH and Me^CO-inducible P 450 makes use of MeX'O a* an end'^erKHi* subatrate in the utilization of the compd for. e^ glutu* prudn under conditiooa of starvation and diabetic ketoacidosis. 104 143521a Theeffeet ef U -dithkblx{l-eth>ltetra>U]*a cyUpLaaak aldehyde dehydrageaase and its implkalkaa far eephaloapoHa-alcwba! raaetkaa. Kitson. Trevor M (Dtp ('hem Biochem . Massey LTniv., Palmerston North, N Z) Ahuhul Chn Exp Res. 1494, 10(1), 27-32 (Eng). Cephatokpitrm [11111-12.4] antibiotic* with a l-fDelhyltetrazoiyl-5-thio side chain have the ability to cause an unpleasant flushing reaction if they are taken aome time before EtOH- [44-17-5] con.umptiun ll I- prupnvd th,l tb, tipUnitiun lot thii u that the ndf chain breumn liberated in vivo and oiidimd u>5J -dithiol>u[l-mtth\ltrireititrl l|| {47471-54-,] or to a tniird diaulfidr anala, which then inactivatn a/dchtd.1 dthyiintnott [M24-44--4]- Support for thi- propoaal u. 4tvan by thr interact ton in vitro between the dimlfide- and aheep liver rytoplaamk aldehyde dehydro^naae, I ha> a rapid and pronounced inactive affect, very rintilar in many trip (though not idrnticali u> that of diaulfiram. to which it haa a atructural vinnlartty - 5 mrth\Ithiotrlraiolr [45704-44-5] rwhich i, a aimple Rndel of the antibiotic) and l-mtth}ltttnrolf-S-thiol (l,l55-7*-4] have no efTect on the tniyme in vitro, but meth\l 5 II mrth\llrlroto/\l) dimlfidr (141444-44-7) it a potent inactivator, thiv ah.. HippoCa the propoaed pathway, 104 145427b KfTeet af etbaaal aa faaaaaa-atBiaabatyrie acid ia the rat: iaUracttaa with caraltlae. Corbett, R_, teonard B E. (Pharmacoiaiy Dep., I'niv, Coll Galway. Galway. Ire 1 Hint ASI 00004791 l