Document Emv9455ZyEdNgmqR8KVGwQ2gb

Chemicals & Polymers ADDITIONAL NOTE TO CERTAIN RECIPIENTS WITH aslAcm REGISTER, REVIEW DATE 1 JANUARY 1989 R. W. FRASH Your ref 0urref BB/BGS ICI Chemicals & Polymers Limited Occupational Health PO Box 4 Hillhouse Site Thornton Cleveleys Blackpool FY5 4QD Tel (0253)861444 (0253) 861632 Direct Line (0253) 861370 Secretary Telex 67483 ICIPLH G Fax(0253)861861 Feb 1989 Dear Colleague I have been asked to make a special request to you, to try and obtain specimens of liver tissue from ASL/VCM cases, and forward them to Professor Tamburro who is looking at research into Oncogenes. His address is : Professor Carlo H Tamburro, M D Department of Community Health School of Medicine, 119A University of Louisville LOUISVILLE Kentucky 40292 USA May I thank you in advance for your help. Yours sincerely L, 1 Lu^ll Dr Brian Bennett 6ENC 008120 ` t MM\ M I ft . i i t I ['HIT zinf-'l TU-lt" + f'L: i +. + + t t f f + i t T i * f+ MM r+i i !_.! i i V1 : i1 M : t1 t i f\|1 *r i rr ; 1 4 ! ! 'l-'i 1 !' 'll ' i ! I * * I t I M* t \ M I t t * ! I i ; !trr f i ; t l t M- I' IL Ib.MllIU nrir ro'tiion riObh i j ! :t i't * hF ill j-.j ii 1 t ' < ' + ( 1 i It H t M t r t * f J t t r i 1 r I i - i t - * lI : 'll -i! i' ,- N l-' ' 1 i :r I * M + } f T T r. GENC 008121 yicsTXTLS traxsktsstok covtt SBxrr t i DALE: XO: FROM; 0f)t\/ 5#&/A/6S'/&<=i _________ `^SoHA/Xortf^01/ _____________________ _____ Ext. 9\j CtnCorp, Inc, 175 Ghent Road Akron, OH 44313-1300 THERE WILL BE A XOTAI. OP PAGES, IHCLUPUNG lfi!$ T?!! Xou RECEIVE ALL v3 PAGES, OR IF THIX ARE HOI LEGIBLE, PLEASE CALL IL^ 10 NOT I _ 3Y,OPERATOR INDICATED BELOW imEDlAXILT Al (XlSl 369 / ^4vf/e e/ acsinile -Oppeerator OUR,NACHTNE IS A RICOH - SAPICOM 120,. GROUTS l/Il/III - AUTOMATIC; ANSWER TEE NUMBER IS CRISI 869-4211 TKANX XOU-' ' GENC 008122 ) GenCorp May 8, 1989 Dr. Brian Bennett ICI Chemicals & Polymers Limited Occupational Health P. O. Box 4 Hlllhouse Site Thornton Clevelays Blackpool FY5 4QP Lancashire, England 176 Ghent Ro*s Fair!awn, Ohio 44313-3300 UbI: 216*889-4200 Fax; 218-660-4211 Dear Dr. Bennett: I have just been informed that a person who previously worked at our PVC Resin plant in Ashtabula, Ohio, recently passed away and the diagnosis on the death certificate was "Angiosarcoma." An autopsy has confirmed the cause of death was Angiosarcoma. Based on this information, it would seem that this individual should be added no the World Register of Cases of Angiosarcoma of the Liver. I will give you the information, as I have it, in the numbered sequence across the top of the log sheet: 1. Country and Reference u.s. No. 36. 2. The individual's name is Joseph R. Succi. 3. His date of birth was September 8, 1921. 4. The name of the company is GenCorp (formerly The General Tire & Rubber Company). 5. The factory was located at Ashtabula, Ohio. 6. Mr. Succi's first exposure was April 14, 1955, 7. The date of the diagnosis was November 26, 1988. 8. Mr. Succi was age 67 at the time of the diagnosis. 9. Had approximately 33 years of exposure to diagnosis. 10. The plant terminated operations December 31, 1983, making his years of exposure approximately 28 years. GENC 008123 Dr. B. Bennett ICI Chemicals & Polymers Limited Blackpool FY5 4QD Lancashire, England May 8, 1989 11. The date of death was January 10, 1989. 12. The histological confirmation is in the form of an autopsy. 13. I have no real way of knowing what his estimated exposure level would be. 14. Mr. Succi started as a maintenance labor trainee, and was a janitor laborer for a short period of time. In December of 1956, he became a shift mechanic, and from February 1959, through his retirement date, he worked basically as an electrician in the plant. 15. other career highlights - Mr. Succi!s official retirement date was January 1, 1384. If any additional confirming information becomes available, I will forward it to you as soon as possible. If I can be of any further help, please let me hear from you. Sincerely, RNJ;np cc: R. W. Frase R. L. Malcolm Roy N. Johnson, Director Corporate safety, Health & Environmental Affairs -2&ENC 008124 CONFIDENTIAL World Register of Cases of ANGIOSARCOMA OF THE LIVER (ASL) due to VCM REVIEW DATE 1st JANUARY 1989 ********* Collated by: Or Brian Bennett Occupational Health ICI Chemicals and Polymers Ltd Hillhouse Site PO Box 4 Thornton-Cleveleys Blackpool FY5 4QD (Telephone (Telex England (Facsimile 0253 B61632 ) 67483 ICJPLHGJ 0253 861861 ) GENC 008125 LIVER ANGIOSARCOMA CASES CIRCULATION OF REGISTER CONFIDENTIAL FEBRUARY 1989 APPLETON B BAGSHAW Dr I M M BAND Dr P R BARON Dr C BARRAT Dr G BAXTER Dr Peter BAYLAC Dr BELLEC Dr BENECH Dr M BENNETT Dr B BERTAZZI Dr P BERTUZZI M BEYNON D W S BISHOP Dr C BORRELLI F E BRAUN Dr C L J BREWER Dr M D BRYSON Dr D D BYREN Dr David CARTER Dr J T CATANZARITI A CELLA C CHANCE M CLARKE Dr E A CLAYTON H CONTASSOT Dr J C DAVIES J G DE JONG Dr G DELORME Dr F DEPLAN Dr F DIETZ Dr H W DOLL Prof Sir Richard DOMBROWSKI S L S DRUMWRIGHT Dr J R DUPONT G EMMINGER H ERNST Dr W EVANS Dr A E J FALK, Dr H FAVRE Dr FIELDING Miss C FtLLINGER J FINCHAM Ms Shirley FOA Prof V FORMAN Dr D FRASE R W FREIESLEBEN Dr W FRIEDEL Dr H P GAFFEY Dr W GOTTESMAN R T GROISMAN D ' HILLMAN Dr D W HOWARD Dr J K HUMPHRY Dr N F ICI Runcorn, UK Hydro Polymers Ltd, Newton Aycliffe, UK Cancer Control Agency of British Columbia, Vancouver, Canada ICI Runcorn, UK AECRP, Commentry, France University of Cambridge, UK Atochem, Chauny, France Rhone Poulenc, Aubervillers, France Naphtachimie, Lavera, France ICI Hillhouse, UK Inst of Occupational Health, Milan University, Italy EVC, Brussels, Belgium ICI Runcorn, UK EMAS,1 Cardiff, UK Georgia Gulf, Delaware City, USA Akzo, Arnhem, The Netherlands Imperial Oil, Sarnia, Ontario, Canada ICI Wilton, UK Nobel Industrier, Sundsvall, Sweden EMAS, London, UK F.VC, Brussels, Belgium EVC, Brussels, Belgium ICI Runcorn, UK Ontario Cancer Foundation, Toronto, Canada Norsk Hydro, Newton Aycliffe, UK Atochem, Saint-Fons, France EVC, Brussels, Belgium Shell, An Den Haag, Holland Quebec, Canada Atochem, Jarrie, France B F Goodrich, Akron, Ohio, USA Imperial Cancer Research Fund, Oxford University, UK Dow Chemical, Midland, Michigan, USA Vista Chemical, Houston, Texas, USA APME, Brussels, Belgium VKE, Frankfurt, Germany Berufsgenossenschaft der Chemischen Industries, Nurnberg, Germany Lever Bros, Warrington, UK Centres for Disease Control, Atlanta, Georgia, USA Atochem, Montluel, France ICI Millbank., London, UK Solvay, Brussels, Belgium Alberta Cancer Board, Edmonton, Canada Inst Industrial Medicine, Milan, Italy Imperial Cancer Research Fund, Oxford University, UK DiversiTech General, Akron, Ohio, USA ECVM, Brussels, Belgium Berufsgenossenschaft der Chemischen Industries, Heidelberg, Germany Monsanto Co, St Louis, Missouri, USA The Vinyl Institute, Wayne, NJ, USA Electrochemical Industries, Acre, Israel Diamond Shamrock Corp, Dallas, Texas, USA University of Otago School of Medicine, Wellington, New Zealand ICI Australia, Melbourne, Australia WPX/ASL - ASL_ADDRESS,1 GENC 008126 JOHNSON Dr C A JOHNSON Roy N KAIPERT Dr J H KLEIN Dr H LAGAST Dr H LANHAM Dr John LANOUZIERE Dr Claudine LAWRENCE-JONES Sir C LEE Dr F I LEL8ACH Prof Dr WK LEVEQUE Dr G LEVISON Prof Dr D A LEWIS Dr P LIGO Dr R N LO MARTIRE Prof N LUSS R D LUSSATO Dr Josette MALTONI Prof C MATTIUSSI Dr R MELTON B MIDDLETON D MOKKA Mr MONTESANO Dr R MOTTI Dr A A MUNOZ MOUTON Dr M MacSWEEN Prof RNM NAKAMURA Dr S OSMAN Dr J PADDLE Dr G M PAGLIALUNGA Dr S PAQUET Dr Christiane PATERSON Dr J C PIRASTU Dr Roberta POSSBERG Dr J PUECH Dr A M PURDHAM Dr J RAMBAUD Dr J RICHARD Dr A ROBSON Mrs D RODRIGUES Dr MJF RUTY Dr J SALG Dr Joyce A SCHIPPER Dr H SCHUCKMANN Dr F SERONNE Dr D SHAH Dr Has SIGRIST Dr J SIMONATO Dr L SMITH Prof Allan H SMITH J S SMITH Dr P M SPIRTAS Dr R STAFFORD Dr J STAHNECKER Dr E SULAIMAN Dr 2- - Goodyear Tire & Rubber, Akron, Ohio, USA GenCorp, Fairlawn, Ohio, USA Dow Chemical Europe, Horgen, Switzerland Dynamit Nobel, Troisdorf, Germany Solvay, Brussels, Belgium Dow Chemical, Midland, Michigan, USA Solvay, Tavaux, France Chief Medical Officer, ICI, London, UK Victoria Hospital, Blackpool, Lancs, UK University of Bonn, West Germany CDF Chimie, AZF, Buily-les-Mines, France Guy's Hospital, London, UK Chemical Industries Association, London, UK Dupont, Wilmington, Delaware, USA EniChem, Milan, Italy Occidental Chemical, Pottstown, Pennsylvania, USA Atochem, Port de Bouc, France Institute di Oncologia, Bologna, Italy Montedison, Milan, Italy Formosa Plastics, Delaware City, USA Hydro Polymers Ltd, Newton Aycliffe, UK Neste Oy, Espoo, Finland IARC, Lyon, France Duperial SAIC, Buenos Aires, Argentina Rio Rodano, Madrid, Spain Western Infirmary, Glasgow, Scotland Japanese PVC Association, Tokyo Health f Safety Executive, Bootle, UK ICI Central Medical Group, Alderley Park, UK Montedison, Novara, Italy Atochem, Serquigny, France ICI Runcorn, UK Istituto Superiore di Sanita, Rome, Italy Wacker-Chemie, Munich, Germany Atochem, Brignoud, France University of Toronto, Ontario, Canada RP Recherches, Antony, France Rhone Poulenc, Roussillon, France Saskatchewan Cancer Foundation, Regina, Canada ICI, Sao Paulo, Brazil Atochem, St Auban, France NIOSH, Cincinnati, Ohio, USA University of Manitoba, Winnipeg, Canada Hoechst, Frankfurt, Germany Diamond Shamrock, Dallas, USA CMA, Washington DC, USA Shell Chimie, Berre L'Etang, France IARC, Lyon, France University of California, Berkeley, USA ICI Hillhouse, UK Llandough Hospital, Penarth, UK NCI/NIH, Bethesda, Maryland, USA Somerset, UK BASF, Ludwigshafen, Germany Arabian Petrochemical Co, Saudi Arabia WPX/ASL - ASL ADDRESS,2 GENC 00312? -3- TACHECI Dr H TAMBURRO Prof CH ten BERGE Dr W F TENKHOFF Dr N TEPPER Dr L B TERWIESCH Dr B THERIAULT Dr GiUes THIIS-EVENSEN Dr E THOMSON Dr D H TONER H P VAN DER MERWE Dr H J WALLACE J R WALTEMATE H WEJDLING S 0 WILLIAMS Dr DMJ WILSON Prof R YORK J YOUNG A E ZOBER Dr M A Hoechst AG, Frankfurt, Germany University of Louisville, Kentucky, USA DSM, Geleen, The Netherlands Huls AG, Marl, Germany Air Products, Allentown, Pennsylvania, USA Huls AG, Marl, Germany McGill University, Montreal, Canada Norsk Hydro, Porsgrunn, Norway Cancer Treatment & Research Foundation, Halifax, NS, Canada Society of the Plastics Industry, Washington DC, USA AEC1, Sasolburg, South Africa Esso, Sarnia, Ontario, Canada BF Goodrich, Cleveland, Ohio, USA Norsk Hydro, Stenungsund, Sweden BP Chemicals International, Barry, UK Harvard University, Cambridge, Massachusetts, USA EVC, Brussels, Belgium EVC, Brussels, Belgium BASF, Ludwigshafen, Germany From: Dr B Bennett, Occupational Health Department, ICI Chemicals & Polymers Hillhouse Site, PO Box 4, Thornton-Cleveleys, Blackpool FY5 4QD, England > I I l I i i [ WPX/ASL - ASL_ADDRESS,3 GEbiC 00 8 22 3 CONFIDENTIAL REGISTER OF CASES OF ANGIOSARCOMA OF THE LIVER DUE TO EXPOSURE TO VINYL CHLORIDE - REVIEW DATE 1 JANUARY 1989 PREFACE : ACKNOWLEDGMENTS, SIGNIFICANT CHANGES, COMMENTS AND REQUESTS 1 The 7 new cases in the Register are the following: Canada 13; France 23, 24 and 25; Italy 07; UK 15 and 16. 2 There are amendments from the previous Register against the following cases: Canada 11 and 12, UK 14 and US 4l. 3 I would like to thank the following for information about new cases: Dr Dietz, Dr Contassot, Dr Lagast, Dr Benetta, Dr Williams, Dr Smith, Dr Lee. 4 For additional information about other cases I thank also Dr Delorme, Monsieur Bibeau, Dr C A Johnson, Mr Roy N Johnson and Professor Lelbach. 5 So far as I know the following people are still alive: cases France 15, 22, 23 and 24; Germany 31 and 32; US 33 and 36. Is this correct? This is important information for the industry world-wide and I would appreciate news, especially regarding the cases in Germany, please. 6 Tables 4g and 4h have been enlarged by the addition of the factories at Tavaux (France) and Hillhouse (UK), as each of these has now had 4 cases. 7 I should be glad if all recipients of this Register would continue to keep me fully informed of any new cases, or give the name and address of someone who can send me the necessary details. I have again attached a blank sheet at the back of the Register so that information can be supplied under the appropriate headings, so far as possible. Please also send any other relevant information about earlier cases, or about factory changes. 8 RESEARCH: (a) May I again ask that all individuals involved in relevant research keep me informed and if possible send me reports. Perhaps recipients of this Register would pass on my request. (b) Co-factors - I have recently met Professor Carlo Tamburro at the University of Louisville, USA, to assess the data which many of you kindly sent in response to my questionnaire about possible co-factors with Vinyl Chloride. We found there was no correlation within Europe, but among the North American cases there was a suggestion of a co-factor effect on latency. In plants where Di-Ethyl Maleate had been used, the latency period seemed to have been shortened. 9 There was an excellent response to the circular I sent in June 1988 about the Register mailing list. Thank you. Please continue to keep me up to date with news of retirements, movements and changes of address. FROM: Dr Brian Bennett, Occupational Health, ICI Chemicals & Polymers Limited Hillhouse Site, P 0 Box 4, Thornton-Cleveleys, Blackpool, FY5 4QD, England February 1989 BB/BGS 003129 Index Table Sequence Belgium Canada Czechoslovakia France Germany Italy Japan Norway Sweden UK USA Yugoslavia Incidence of Cases per annum (Table 1) Distribution of Cases by Country (Table 2) Pattern of Cases by Factory (Table 3) Latency Periods (Table 4A) Distribution of Latency Periods (Tables 4B-4H) Annual Geographical Incidence (Table 3) ICI CHEMICALS & POLYMERS LIVER ANGIOSARCOMA CASES (REVIEW DATE - 1 JANUARY 1989) 1 Page 1 1 WPX/ASO - LANGIOCASES,4 Page 1 2-3 4 1 ASL Case Numbers by year of Death 1 (Table 6) 1 1 ASL Case Numbers by year of first exposure [ (Table 7) 46 47 5-9 1 Western Europe PVC Producers - Start-up Dates vs ASL Cases 48-49 1 (Table 8) 10-15 1 1 USA PVC Producers - Start-up Dates vs ASL Cases 16-17 I (Table 9) 50-51 1 18 1 Canadian PVC Producers - Start-up Dates vs ASL Cases 1 19 1 (Table 10) 52 1 East European PVC Producers - Start-up Dates vs ASL Cases 53 20 1 (Table 11) 21-24 1 Japanese PVC Producers - Start-up Dates vs ASL Cases 2,5-32 1 I (Table 12) 1 South & Central American PVC Producers - Start-Up Dates 33 1 (Table 13) 54 55 34 1 Australasian PVC Producers - Start-up Dates 1 (Table 14) f 35 Middle Eastern PVC Producers - Start-up Dates 1 (Table 15) 56 57 36 1 Blank form for notifying new cases i 1 37 1 38-44 1 1 1 1 45 1 1 1 A WuNC Page l BELC[UK 1 NO BELGIUM 01 02 ICI CHEM 1 CALS 6 POLYMERS LIVER Angiosarcoma Cases - (Review Date : I January 1989) WPX/ASL - LANCIOCASES,6 2 3 4 |5 NAME Ok INITIALS DATE OF BIRTH COMPANY j FACTORY 12*01,13 Solvay | Jemeppe ss 29 09 AO Solvay 1 Jemeppe 1 1 ' 6 FIRST VC EXPOSURE 00.07.58 20 08 62 7 DATE OF DIAGNOSIS 00.05.76 00.10.79 8 ACE AT DIAGNOSIS 63 39 9 t 10 YEARS OP | YEARS OF EXPOSURE TO t EXPOSURE DIAGNOSIS 18 1 L ? 17 1 9 1 1 12 , DATE OP DEATH HISTOLOCICAL CONFIRMATION 29.06.76 Yes 23 10 83 Yes _ ________ _ ,, 11 13 | 14 1 15 1 J6 11 1 ESTIMATED | 1 1 OTHER \ OTHER EXPOSURE | OCCUPATION 1 CAREER |' COMMENTS LEVEL | f H1CHLIGHTS 11 11 1t 1 High | Au toe 1 ea ne r (Driller In a |Kepat1c tests |14 yrs Ifoundry |in Oct 1974 1958-1968 | 1(2 yrs) 1 we re nurma]. exposed to| Poly worke r IFarmer (Retired 200 ppa |3 yrs 1(15 yrs) [Feb 1975 for 8 hra | J Work In glass |Hoepltalised per day ( |ind. 4 chemi- (May 1976 and l leal Industry certainly under 500 ppa In 6 to 9.3 ] | | | | 1 i 1 1 1 (Complete |Clin1ca1 and \career detalls [are given In a j pape r by autoclaves) 1 [Hublet et al 1968-1972 | 1 I 1n Arch, be 1g. exposed to| 1 [Med. Soc . * 50-200 ppa| 6 hrs per | day in | 23 1 t 1 l 1 [Hyg. Med. (Tra v. Med. ILeg. 11 97 7 pages. aut oc1av es | 19)2-1974 | 1 1 1603-622 exposed to| 1 50-200 ppn 1 In auto- [ clave roonl 1974-100 | l t l 1 PP 1 1975- 50 | 1 1 PP" RETIRED 1 | 1 1 3 Feb 19751 1 11 11 08.62-03. lAntocleaner IFireman since list sign July 6 J 01.67 |b yrs 5 mths f10 71. | 79 : Thordt J r -J 0.?l (Operator I [pain 07.74. 200 ppm i3 yrs 9at bs. 1 8h/da y | t 04.63-12. | 1 I Hi-jut Jr (tsi s I a 1tered J 0.79. 1 Posit 1ve 66 * 200 ppm | | 1 1 1 1 1 1 1 1 1 1 lechograpliy I l 1.79. IfejM1 Leciony 02.S(l. | Chemo t lit- r ii |i y . 1 In! litCHrkI 1 .Hi IkIvhui n. 11 | J el in 1 i riuy 1 _J J P I 1984 \ rum In | 1 k Mnn.il. tc 0OS 131 Fage 2 CAN ADA Sheet 1 lC[ CHEMICALS 6 POLYMERS LIVER Angiosarcoma Cases - (Review Date: 1 Jan 1969) DAY - MONTH - YEAR All dates use UK system WPX/ASL - LANCIOCAStS,7 1 COUNTRY AND REFERENCE NO CANADA 11 2 |31 11 11 NAME OR \ DATE OF 1 INITIALS | BIRTH 1 i1 1( \i f1 1 4 15| 6 1 COMPANY 1 1 FIRST VC FACTORY ( EXPOSURE t1 l SHAWINIGAN { I * 1l 7 161 9 11 DATE OF DIAGNOSIS ( ( 1 * ACE AT 1 DIAGNOSIS 1 1 YEARS OF EXPOSURE TO DIAGNOSIS f 1 1 10 t 11 YEARS OF I DATE OF EXP0SURE 1 DEATH 12 HISTOLOC1 CAL CONFIRMATION 1 13 J 14 1 1 1 ESTIMATED j EXPOSURE | OCCUPATION | LEVEL | 1 | 15 OTHER CAREER HIGHLIGHTS ( J l f f J 1 1 1 16 OTHER COMMENTS 01 |13,12.13 i 1 1 1944 1 1955 ( 41 11 11 102.09.55 Yes 1l !1 ( \l t1 ! Ii 11 i 1 Q2 |0b.03.14 1 1 1 1943 1 1957 1 43 14 14 121.12.57 Yes l1 J1 ! 11 11 1 1 11 ii 1 1 !1 ii 1 1 03 126.08.19 1 i i 1941 1 1962 1 42 21 20 1 23.03.62 Yes 11 Ii 1 1 It (1 1 1 11 11 1 1I 11 1 1 04 *03.04.19 1 1 1 1945 1 1967 1 48 22 22 I 21.01.68 Yes 1J Ii 1 11 11 1 1 11 ii 1 J 11 1l 1 1 11 1! 1 ( 03 107.05.11 1 1 1 1944 1968 1 57 24 1 05 105.07.68 Yes 11 11 f ( I1 11 1 l1 11 1 11 11 1 J 00 115.12.19 l 1 1 1947 1971 ( 51 24 1 23 110.04.71 Yes 1l 11 ( (1 11 1 1l 11 I 11 11 1 1 07 |09.11.19 1 1 1 1946 1972 1 53 26 25 l 24. 12,72 Yes 11 11 1 J 1l 11 11 11 1 i 11 11 ( i OH ) 11.03.20 l 1 1 (961 1 (97 J ( 53 12 ( 05 ( 12.06.73 Yea l1 11 1 1 1 11 11 1 1 1 11 11 1 1 1 09 119.07.21 f 1 1 1946 1 1974 I 53 28 f 26 104.09.74 Yes 11 11 ( 1 1 11 11 j i 1 1f 1 | Reactor | cleaner | Operator |Smoke r |polyaerlsation| f 1 * Ha Inc enance ,(Operator |11Iwrighc, (pipefitter | Worked lovert Itne fSmoker 1 lOperator, I foreman ( \ |Reactor leleaner 1 \ |Wo r ked lovert line |Non-smoker f Ope rat or t |foreman, |vater cooling 1 1 (Worked lovert tme | Smoker j unit \ ( (Reactor (cleaner 1 t t fReactor leleaner | |Water | unit cooling 1 |Worked lovert lae | Smoker (Maintenance, |11lwrlght (Worked [overt ie |Smoke r * ( fReactor |c Leaner 1 1 IKcartor | clea ne r 1 (Machine shop (operator and Ipoly unit (Worked (over tI me |Smoke r fKrifntenanre Imachlne shop 1 1 ill plant |25 yrs! Smoke 1 fFurnace op. I pipel f[er J ma 1 rite name i | Worked Invert 1 me | Sraok i' [ l'apot by Hr F DH-OHMK In Amules :i' Ani loin I pu I ho 1 ng h] lh? Paris, I97H Vo \ 2 3 No 2 pp 11) 5 - l J 4 cl.il ins [hiH < .isi- hud bc>E h a hepatoma and ASL s IhujIi <iiiuoiibJy, Page 3 CANAHA Sheet 2 NO CANADA 12 n Cl CHEMICALS 6 POLYMERS LIVER Angiosarcoma Cases - {Review Dace: I Jan 1989) DAY - MONTH - YEAR All daces use UK. system WPX/ASL - LANG10CASES,0 1 2 13 11 ll t DATE OF INITIALS | BIRTH 11 11 11 11 4 COMPANY 11 1 5\ 6 i 7j 0 11 11 1 I FIRST VC | FACTORY l EXPOSURE f 1 DATE OF | AGE AT DIAGNOSIS \ DIAGNOSIS 1t 11 11 f1 \ 1 f 1 1 9 YEARS OF EXPOSURE TO DIAGNOSIS 1 l 1 i LC 116.05.15 f 1 I 1 13.10.25 Culf l1 11 11 11 IShawinlgan I1 11 || 1953 1943 1976 Nov 85 | i 1 L I | 1 1 61 60 23 42 i BC 1i 1 114.09.20 Culf l4 li IShawinlgan 11 1] 11 i( 1945 Mar 62 i 1 | 1 1 l 1 61 37 11 1 lI 1 SS | t 1 1 1 ! 1 1 f 10.06.26 BFC 1 | | 1 1 (| 11 1 11 1 J1 1 1 11 1 I l1 i 1 t1 i 1 1 Niagara ( 1957 1987 ! 60 1 Welland | i 1 11 1 11 11 i 1 1 11 1 I1 1 1 1 30 1 || 1 ! 1 11 1 |1 11 1 1 1 | |1 1 1 1 11 1 i| 1 1 1 11 ) |1 1 1 1 11 111 III 1 1 1 11 1 1 1 11 1 1| 1 1 1 11 11(11111 , || | 1 1 11 1 to | 11 1 1 YEARS OF t DATE OF EXPOSURE ! DEATH l 1 1 l 12 HISTOLOGICAL CONFIRMATION 13 1 14 1 15 ESTIMATED f EXPOSURE | OCCUPATION ] LEVEL | OTHER CAREER H1CHLICKTS 4 f 00.04. 77 1 1 J 1 5 )05.04.06 1 1 1 1i i 27 I3L.03.B2 i I l 1 1 1 1 Yee Yea Yea | Reactor J c1ea ne r | Furnace op. (maintenance. (packaging High L1943-47 (Operator 4 tSupervisor |VC Plane |Retired 1972 !(Age U) High Low 11945-55 |Autoe lave |Operator, |PVC Resins |Retired 1972 1(Age 52) 11955-65 tve (Manufacture 1 1 1 j 1 23 |26.1.87 1 1 1 1 11! III III III III III III 111 III III III Yes Mediu 1957-70 High t1965-72 | Au t oclave (Operator, JPVC Resins l (Poly CleanerlRet 1 red I960 (6 Operator |(Age 54) 1970-00 Low |Supervisor 1I 11 II II II 11 II II II II II 1 1 1 1 1 1 1 1 1 1 1 l 16 i OTHER | COMMENTS 1 E jt-smoke r \Let t e rs f rom t Dr Fernand | Delorme > | Pa t bolog1st 6 \ Btbeaii, BFC iLetters from (Dr Fernand | Delorme, (Pathologist 6 |H 61 beau, BhC ( Informat Ion 1 f rom | Dr H U Dietz, |BFC, 1988 1 1 1 1 1 1 1 1 1 1 I Pag e 4 CZECHOSLOVAKIA ICI CHEMICALS 6 POLYMERS LIVER Anglosarcons Cases - {Review Date: 1 Jan 89) WPX/ASL - LANC1 OCASt, 5 , 9 l 2 3 4 15 6 COUNTRY AND REFERENCE NO 1 CZECHOSLOVAX IA 1 I OJ J I I 1 1 1 1 02 1 1 1 1 f 1 1 1 1 1 1 1 1 1 1 1 1 \ [ 1 NAME OR INITIALS DATE OF BIRTH COMPANY 28,06.28 State Co 06.07,27 State Co I9 I1 II II II | FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS j Novaky I 1 01,07.57 2*.12.73 1 ________ o o ; | Novaky 27.1J.64 I t 1 I J t r II I1 II II 9f I_________ I 8 ACE AT DIAGNOSIS 45 1 9 1 10 1 1 YEARS Of 1 j YEARS Of | DATE OF EXPOSURE TO | EXPOSURE 1 DEATH DIAGNOSIS 1 1 \ 1 1 1 16 16 |24.12.73 37 14 15 126.11.64 1 1 1 1 1 I I I I I I I I I I 1 HISTOLOGICAL CONFIRMATION Yes Yea 13 | 1 14 1 1 ESTIMATED 1 1 EXPOSURE f OCCUPATION | LEVEL | 15 OTHER CAREER HICHLICHTS 1 | 1 1 | | { \ Autoclave |Cleaner 1r 1 \IARC letter 1 j |of 1-4-62 | Iglvlng detal1s| |f roo Prof | |A David of | I Cent re 1nd | (Hygiene and | |0cc diseases, j |Autoclave |Cleaner 11 f1 11 ARC letter of 11-4-82 gave | {sonewhat f lettered dates j | for this case . 1 |I have | |accepted t he | Ichanges since | |the dates cooej jfroa Prof | |A David of the| (Centre of 1 |Indus trial \ [Hygiene and | J Occu pat 1ona1 [ {Diseases. My j | d at es come | |o rlglnaily | (from NI0SH. j 11 i t> OTHER COMMENTS J 008134 Page 5 FRANCE Sheet 1 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH 15.04.24 03.06.11 03 27.01.27 29.01.38 1CL CHEMICALS 4 POLYMERS LIVER Ang1oearcoma Cases - (Review Date: 1 Jan 89) UPX/ASL - LANCIOCASES,JO Rouss illon Brignoud Brlgnoud Brignoud FIRST VC EXPOSURE DATE OF DIAGNOSIS 18.02.67 06.07.59 00.00.46 15.01.75 18.01.65 ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH 29.06.75 04.01.76 J 3.05.76 HISTOLOGICAL CONFIRMATION Yea IN10SH no ent) 13 J ESTIMATED | EXPOSURE | OCCUPATION LEVEL f I f I OTHER \ | OTHER CAREER \ COMMENTS HICKLICHTS I ____________ I____________ f I High High High J Au t ocLave Jworker and |c leaner f 19 yre I I____ I |2 yrs on |monomer |JO yrs on | polyaer\lsatIon I I )Polyworker |10 yrs as Jautoc Lave jcleaner j Compounding (3 yrs \Ref. Rav1er et | a I Arch. Ha 1 . |Prof . 1 30 n' |3 Nov 1 5 IP 171-677 Italian l Ref . origin |C Bonneton et fal "Nouvel1e 1presae |edlea 1e" f 5 Nov 1977 IP 735 J___________ I VCM producCJonfRef. Rety et 16 yrs|al Arch. Mai. Italian PQW |Prof. I 37 n' Shepherd, j6 June 7* Sawyer, Mason |p 551-555 I High High I IMonomer | product Ion fworker |8 yrs J PVC If lit rat Ion jI 8 yrs I j Ho J y wo rker It J yrs 6 )Thoracotomy I I | Ref . f Coucl re th Feb 1976 |et a! "Semdine ost al |des luisp j t jux ngiosarcoma JI0 Septembre )SclntIgraphy 1 1976 Ound ASI. |Previously had )Haemorrhage J bone rum ASL )RIght p.*t e c t omy j dng 1 osa r i imui |A I so |I Mi liow.Jt | i | iH I I it N.miv,- | | fPrevse Med 11 ,i 1 |7th July 19/9 IP.ige *4H'i 61^008135 Page TRANCE Sheet 2 ICl CHEMICALS 6 POLYMERS LIVER Angiosarcona Cases - (Review Date 1 Jan 1989) WPX/ASL - LANCIOCAStS,I I 1 1* 1 1 COUNTRY AND f REFERENCE I NO | ( FRANCE 1 j 21 1 NAME OR I INITIALS | 3 DATE OF BIRTH 06 |Pa 1 1 1 t 1 1 f 1 1 ( ( 07 |Clft 1 t i 1 1 i 08 i a i 1 1 1 1 i 14.04,34 1 (26.04.27 1 1 1 1 1 1 JOi.04.34 1 i l l l I 4 COMPANY 1 1 5 16 1 1 | FIRST VC | FACTORY | EXPOSURE 1 1 t t 1 7 1 8t 9 DATE OF DIAGNOSIS AGE *T ( YEARS OF DIAGNOSIS | EXPOSURE TO DIAGNOSIS 1 io ( ii 1 i 1 1( YEARS OF ( DATE OF | EXPOSURE ) DEATH 1 \1 11 \1 1\ 9 12 i 1 HISTOLOGICAL | CONFIRMATION | ] 1 1 1 13 1 14 ESTIMATED EXPOSURE | OCCUPATION LEVEL 15 OTHER CAREER HIGHLIGHTS ( 1 1 1 ( ( 1 16 OTHER COMMENTS 1 PCUfc RP So Way |Brlgnoud 101.03,58 12.OS.76 1 1 t 1 1 1 1 1 1 1 11 > (Sc Auban i 01.07.50 { After I( 1J 1\ 1( { death ( NIOSH 1 says 1 00.07.76 11 1 1 |T avaux 11 1 23,05.5? | 03.12.75 11 ) 11 1 11 1 1t i 1 11 1 _L I | { ( I | 1 1 j 1 1 1 i 1 42 49 42 1 18 L 26 19 13 1)1.09.76 I IfNIOSH | l**ye | 1 12.09. 76)1 t1 ti 11 11 ii 11 Yes | Moderate 1 1 1 1 1 1 1 1 l |( 1 958-1960) 12 yrs 1flIt ration |10-J1 yra I polyworker (and works (lab? (This man had |A0L prior to j AS. Ann. d e |Mal, Prof. (July ;? Ip 645 & 6. |AOL was found (in 1971 five ]yra before IASL 11 1 1 1 11 1 22 102.07.76 I Yes 1 High 1i (Plant fore- |J972-6 adaln (Died of 1 1 1 (NIOSH no |an in (section In J eep t Icaernt a 1 1 1 consent) 1 polymer- |St Auban JSaall liver t 11 (laation (lesion found 1 11 1 (after autopsy 1 l( 1 1 1 11 1 19 130.01.77 1 Yea 1I ( Mode rate (6 yra packer( lU..d br.-T, 1 11 |k autoclave (tunnel worker 1 11 |c lnr (previously 1 11 | 9 4 yrs l J )1 |autoclave | 1 I1 |worker 1 1 1> 25.12.77 J Very High Polyner- 10 yrs in J I (Operated 4.; b 1948-1966 1 set ion sulphuric | for rernov a l etf Lesser operator, acid factory, |tuour fr Exposure autocleaner,, storekeeper & (liver and 1966-1976 autoclave general (died afte a 1nt ena nee services (second (surgical loperacIon |b! Mq | b ronclt f a 9 If1stnla (Paper by |Dr Rety t a! (in Archt v f s de (Maiddes (Proles*! (Vol 4 0 h 9 1979 (lag 9 7 4 | - 1. j MC 003136 Page 8 ICI CHEMICALS 6 POLYMERS VPX/ASL - LANGIOCASES,l3 FRANCE Sheet 4 LIVER Anglos arcooa Cases - (Review Date: 1 Jan 1989) 1 1 \ 1 COUNTRY AND | REFERENCE | NO 1 1 France 1 1 1 2 |1 1 1 NAME OR 1 DATE OF INITIALS | BIRTH 1 1 1 1 15 1 DEP 1 1 l l 1 1 1 lb 1C1M 1 1 f 1 3 |03.0I. 37 J I 1 1 1 1 111.07.22 f 1 1 1 1 4 COMPANY 1 1 5{6 7 1i f1 1 1 1 FIRST VC DATE OF | FACTORY I EXPOSURE DIAGNOSIS 1l 1 _L 1i 1[ 11 1 8 1 9 1 10 1 M 1 12 1 13 1 14 1 11 1 f ACE AT 1 11 1 f | YEARS OF 1 YEARS OF| DATE OF t HISTOLOC1CAL j ESTIMATED | DIAGNOSIS 3 EXPOSURE TO|EXPOSURE] DEATH CONFIRMATION | EXPOSURE j OCCUPATION ] | DIAGNOSIS i 1 | LEVEL 1 1 1 11 1 i I3 1 1 11 15 OTHER CAREER HIGHLIGHTS [ 1 16 1 1 | OTHER | COMMENTS 1 1 | Left HepatecL otny 1 1931 Chloe I St Fona Chiale J ( foraerly 1 RP) 1 1 1 1 Chloe 1 | S t Fons Chiale 1 (Fo naerly 1 RP) 1 1 1 1 07.07.55 28.09.82 17.10.41 Q5.01.B1 1 1 1 1 1 i 45 61 1 21 | | 1 | 1 [ J 1 41 3 1 1 I 1 2? |Alive !1 1I 11 f1 1t 1J 3! | 18 101.04.81 11 11 11 11 11 Yea Yes | High-20 yr |Mode rate 1 7 yrs 1 1 | Autoclave [c leaner | 1955-1962 | autoclave [operator | 1962-1982 1 |High-31 yrs |Polyaerlsat |Moderate- lion Process |Low - 5 yrs|Man | Maintenance | Worker |J C Contassot [Letters of 15 10 1933 and [29 7 88. | 1 [ | Ret I red [Jan 1979. |J C Contassot [Letters of |5 10 1983 and |25 7 84. 1 1 1 1 17 | KAR 1 1 1 1 1 1 1 1 1 1 13 [R 1 1 1 J 1 1 1 1 1 1 1 1 [ \ 1 1 t f 1 122.02.21 1 1 1 1 1 1 l 1 1 1 ) 14.07.42 l ! 1 1 1 1 1 f 1 1 1 1 I 1 1 Chloe 1 1 r l | St Fons Chiale (Foraerly RP) l i i i i 3 3 Solvsy 1 1 1 |Tava ux 1 1 1 1 I 1 1 1 1 1 1 1 1 1 1 17.06.43 - 03.04.81 09.09.63 21.03.84 1 1 1 1 1 1 f f 1 i l i i i i i i 60 42 3 i 1 34 ! 1 1 3 1 1 1 2J [ 1 [ 1 J i 1 1 1 1 1 1 1 f 11 1I 11 11 | 28 101.04.81 11 11 11 31 !1 11 11 11 11 ff 1 21 |27.[2.84 11 11 11 11 11 11 1 [1 f1 f1 13 11 1 11 11 1f |Health 4 |5afety Agentj 1 1 * Yes (High - [Autoclave | 21 yrs |Cleaner [1948-1971 ti 1 3 1 1 21.03.84 1 f1 |High-12 yrs|Autoclave |Low - 9 yrs|Cleaner 11 | 1 1 t 1 3 i \ 1 1 1 f |0ther sectors |of St Fons |Factory ]97J 11978 J f Ret I red J0i.0l.79 |J C Contassot | Letter of 15 10 1983 f 1 1 1 1 I 109.01.84 IKlglit |Hepa t ect omy [05.05.843 24.09.34 | c henot he r ,i|s y | f ni lung- |met as L aw 1s |partlal |remission. |08.84 - 3 lv< r | ret iirreiici'. J 10.34 - lung | e vo 1 i.i l 11 mi i; f | t he disense 1 'IC 008138 FRANCE Sheet 5 I CltbHICALS & I'ULYMEKS LIVER Angiosarcoma Cases - (Review Date: l Jan 1969) J5 I COUNTRY AND REFERENCE NO FRANCE 19 20 1 1 1 1 1 [ 1 \ 1 1 [ l t r 21 NAME OR INITIALS DATE OF | BIRTH f COMPANY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS MA2 BR Pa 1 1 1 j 15.12.32 t 1 1 1 J02.03.23 1 1 1 1 1 1 1 1 J 101.10.40 1 At ochem Atochem RP 11 1 11 1 11 1 [Brignoud | 07.04.59 | 11 1 11 1 _JL 11 ! Brignoud J J95I J J 1 11 1 Jf 1 11 [ 11 4 1J 1 1J 1 11 1 f1 i [ | SEP FJ | 1959 | JHootluconl 1 1 28.10.84 1 1 f 1 f 27.12.85 f l 1 1 4 i J 1 1 1 1 _! 03.06.86 1 1 52 63 45 1 1 1 ! F r \ 13.08.28 | Atochea \ St Auban | 01.09.58 | 05.J1.87 I 07.02.27 | Atochea jSt Pone 1988 59 08.!2.28 | Atochero Brignoud 1943 1988 |02.03.30 I Solve* i 3 982 56 YEARS OF EXPOSURE TO DIAGNOSIS f \ 1 25 1 J 1 i 1 34 1 l l 1 f 1 J f 1 1 27 1 1 YEARS OF EXPOSURE DATE OF DEATH JJ 1\ 11 25 (06.11.85 | i4 14 11 11 22 126.12.05 | 11 11 E1 ri ii if ii ir ji 4 12B.06.86 I 1J 35 23 I07.05.B8 HISTOLOGICAL ESTIMATED | f OTHER | OTHER CONFIRMATION EXPOSURE } OCCUPATION J CAREER | COMMENTS LEVEL | | H1CHLICHTS I 4 11 1 | Myo ca rd 1 a E f |Autoclave | " | inf arc tion 1 loperator and| Yea 1 High Jcleaner | |3 980.Coronary Jbypass ]96 t. 11 f |Let ter f rom 11 1 |Dr Con t as s ot JF 1 15.4.86 14 |Portal Yes 1 High J Autoclave |[n other partsJfibrusis from 1 loperator and|of factory 126.04.74. The 1 | c1eaner lalnce 1946 |i1 1 nes s wa s 1J |d 1 agnosed as 11 | p res Lima b l y t1 fwork related 11 Jon 2(3.04.74. f1 |Le11 er f rom 1t JDr Conrassot 1f [05.04.86 Yes 1 High |Autocleaner | Ka1nt e nanc e J Hepatic test 1 |4 years 4 worker J Hay 84 norma 1. | HepatIc test |Hay 86 showed |a bnorraalitios. | Le 11 e r f rom | Dr Ba r ra t High 12 years | 16.07.66. | Let t e r s from 1958-70 Aut oclave | Dr Com ,-issut worker. Low | At ochem [2.32.87 and 1970-84 High 14 years In Control Room Autoclave 129 7 86. I___________ | Liver Cleaner A | E. ransp Jam all PVC JHay 1986. >roductIon | fnformation t rom |oba |Dr J C Co n l a s so t High PVC ProdnrtIon | At n c h em , 1 9 H H JPrirt 1*1 2 years J llt'fia t et l innr1 , Ap / 1CV [>et ec t ion | 68 , Ch emol I it* r o py 3 years | Inf orm.i lion ( i om PVC Prortut t I on | Dr Conlj'.sol , mat ritenance f At ochem, [4HH |- 30___________ ] I years) 'olyc leaner J____ IPrlmary liver High) - 5 years | Tumor Me t a ( ,t s 'ri J y H oi r | I u11g . I? r .i 1 n f> ye it r s Coil L rol Room ] 1 ye. It..... . | kidnev, I | I Ilf I I J JTl,i L lull [ ( | Dr 11 [ dg a a L j | SoJ way, J Nij vl-n-Pi i I VHH 00813? AA A Fage [(j GERMANY Sheet 1 [Cl CHEMICALS 4 PLU.YHL RS LIVER Angiosarcoma Cases - (Review Dale: ] Jan ]9BS) WHX/ASL - LAND IIK'ASES , I ' COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH COMPANY | FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIACNOSLS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL | ESTIMATED I I CONFIRMATION | EXPOSURE I OCCUPATION f LEVEL | I OTHER CAREER HIGHLIGHTS J | | OTHER COMMENTS 100.00.30 tOO.00.31 100.00.30 100.00.30 01,10.56 1 19.09.68 14.10.57 * 25.09,70 09.06.52 j 00.03.73 36 13 16.04.57 t 26.11.74 125.01.69 lYes (NIOSH) 1 Polyworker 114.12.71 |Yes (NIOSH) 1 110.10.71 |Yes (NIOSH) | 25.11 .74 |Yes (NIOSH) | Polywrker | FI Hing pesticide | aerosol cartel fvlth VC 1 1 1 1 1 1 1 1 1 200-500 ppa| Polyworker 4 | 1958 was but high (temporary [autocleaner during i yr|autocleaner |for 1 yr autoclearte r [ i \ 1 | Reported unde 1 non po1ymer11 sat Ion (workers In | NIOSH 1 1st of 1)1.3.77. (This of court. | Is strictly Icorrect. Illnuever [ |wonder (whether this. jaan had high (exposure to |VCH in his j can filling to pe ra tlon 7 1 | C11 n i r a l IdetalIs in \ pa per by (Cokel et a 3 1 Vi rchowb At i-li |A Path 1916 |172 p [95-20j -\C 008140 Page I Cl CHEMICALS A POLYMERS WPX/ASI, - 1,AN0 LUCASES . l b GERMANY Sheet 2 LIVER Angiosarcoma Cases - (Review Date: 1 Jan 1989) 1 11 1 ! COUNTRY AND ( REFERENCE | NO ( 1 GERMANY 1 | 11 2 |3t l1 1I NAME OR i DATE OF I INITIALS | BIRTH t 11 11 i1 i1 4 COMPANY l1 !5 6 ! 11 1 FIRST VC l FACTORY EXPOSURE 1 1 1 ! 05 I 1 (HIOSH glvesl ae Case 06) 1 1 1 l 1 1 S 1 1 l 1 1 1 1 I 1 1 06 ( 1 (KIOSH gtves| as Case 05) J 1 1 07 | 1 l ] 1 1 1 l 1 1 1 1 08 | 1 1 1 l 100,00.36 1! 11 11 11 l1 1l 11 l! 11 11 11 11 11 1l 11 11 11 1) 11 100.00.32 1 1l 11 11 1! 11 100.00.26 1 1l l1 s1 11 11 11 11 1( 11 11 1 (00.00.17 ( IJ (1 1! t1 11 B 4 11 1 1 1 02.04.60 1 '7 1 1 1 1 16.12.62 a 15.04.54 1 4 19.07.54 l 11 7 8 I 9 j 10 1 11 12 DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF | YEARS OF t DATE OF 1 HISTOLOGICAL EXPOSURE TO | EXPOSURE | DEATH CONFIRMATION DIAGNOSIS 10.12.73 36 1 1 ! 1 13 1 05 [16.12.74 Yes (NIOSH) 1 1 1 l 1 00.00.75 1 1 1 43 1 J 1 1 1 1 13 ! 1 12,11.75 1 49 1 21 1 11 1 11 1 1 1 11 11 1f 11 06.04.75 1 58 1 20 !1 1( 11 11 1 12 109.01.75 1 21 |13.M.75 ((NIOSH | says (2) 1 21) | 25.12.75 Yes Yes Yes 1 13 ( 1 14 | 11 11 ESTIMATED t t EXPOSURE | OCCUPATION | LEVEL 1 1 l 1 1( 1t 15 OTHER CAREER HIGHLIGHTS 1 1 16 [ | ' OTHER ( COMMENTS 1 1 (Confirmed 1 BC Chemle | |aaya { ("chealat ry [ |laboratorlan| |In the | (Techno- 1 tlogical | (Research | | Department" ( ((NIOSH says | (assistant | (factory } Icheaist I (which may bej |wrong 1 11 ranalatIon)| 1k 1 1 1 | PVC - Kami- 1 1 1 1 1 facture | | Shi ft Leaderl 11 11 1 |PVC Kanu- 1 ( Ifacture and | ( a L1 work | |incl auto- 1 |c leaning ( 11 2 yrs ( 1{1934-66) [ ( Foreman Tectil (Dev 8 yrs I 1(1967-1975) | 1t 11 ( Pn 1 yworker [ 11 1I 1I 11 > (Reported under Inon-polymerf Isatlon [workers In 1NIOSH list of | 31.3. 7 7 and 1 1.78. I don't {think thle Is |a correct | c lass Ificatloi |by NIOSH. Thi |aan may have [been involved (In VCM j polymer!satloi 11 n pilot plan1: [or in main |plant. 1 ( [ 1 1 1 1 1 1 1 1 J [ 1 1 1 ( [ ( 1 1 1 \h v>. StNC 0* lAl - tv. ICt CHEMICALS f. POLYMERS i* UPX/ASL - LANG [OCASES I 7 GERMANY Sheet 3 LIVER Aug 1 on rj r c nms t.iscH - (Krvlrw Itoir, 1 Fan ]9H9) 1 11 L 1 COUNTRY AND J REFERENCE | NO 1 i GERMANY 1 ( 2 NAME OR INITIALS 1 )I DATE OF BlRTK t 1 l l 1 l 1 1 i, COMPANY 15 | FACTORY 09 l l 1 1 1 1 1 l 1 l 1 10 I (NIOSH gives! aa Caee l1 | \ 1 1 1 1 1 i ii (NIOSH gives| as Case 10)1 \ 1 1 1 1 12 | 1 i t 1 ( 1 1 1 1 1 ! 1 1 00.00.34 2 1 2 I 1 1 1 1 l 1 1 1 9 00.QO.36 | 2 1 2 1 1 1 1 1 1 1 1f 1 00.00.29 | 8 te 1 9 1 1 1 I 1 00.00.38 | 4 ( 4 1 1 1 1 1 i 9 1 1 ( 1 I I ft FIRST VC EXPOSURE 20.02.61 01.01.61 10.tO.55 00.00.61 DATE OK DIAGNOSIS t6.06.76 00,01.77 28.06.77 00.10.77 a ACE AT DIAGNOSIS 61 40 47 39 9 YEARS OF EXPOSURE TO DIAGNOSIS 15 16 21 16 i [0 i u j______________ 1 YEARS OF DATE OF EXPOSURE DEATH 12 HISTOUX.TCAL CONFIRMATION 1i n 1 14 | 11 1t ESTIMATED 1 1 EXPOSURE | OCCUPAJION | LEVEL t 1 (1 11 11 15 OTHER CAREER HIGHLIGHTS 1 i 1 | \ 1 1 9 1 16 O'tllFK COKMENIS 13 24.03.78 10 07.03.77 22 28.06.77 6 07.10.77 Yes Yea Yes Yes High peaks j J 2 yrs poly-j | worker lncl | | 17% auto- | jelave |cleaning J | (Control rooa| 1 1 yr 1 11 11 High peaks 1t 11 110 yra poly-| Jworker lncl l |17% auto- | (clave 1 Icieanlng \ High l1 11 [1 11 (i |3 yra auto- | (clave |c leaner |19 yes 1 [ | IfUter (operator | | 11 l1 > |PVC Hanu- | (facture ) (Autoclave | (worker tor J |6 yrs ( 1| 11 11 1j 11 91 1t 11 11 I 10/78 |Conf1rraed |Average (exposure first (9 yra 150 pfxn (occ (000 [pm jNext 3 yrs av |75 ppffl Last Jyr av 35 ppm 9 t 1Ave rage (exposure f1rs | 9 yrs J 50 pptn |occ 1000 p(u (Last yr av (75 ppm. CUH 1 let ter of (21.04.78 1 1 1 9 l ( [ 1 I 1 | l ! 9 1 1 1 1 ( ( 1 1 f \ tCrWj&Ubjfat 1C 008142 Page 34 GERMANY Short 5 Id CHEMICALS 4 POLYMERS LEVER AngJ osa rcosna Cases - (Review Dait J JAII J "07} WPX/ASL - LANCtOCAStS.19 IS COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT D1ACN0S IS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCU RATION OTHER CAREER HICKLICHTS OTHER COMMENTS GERMANY 17 (NIOSH gives a? Case 15) 01,11.61 I4.0fl.78 00.00.11 00.00.25 00,00.15 00.00.55 25.12,79 18.10.54 00,08.79_ 66 54 14.02.61 00.04.80 65 23 1 1 1 1 i I 22 1 100.00.13 1 4 l 4 1 01.01.62 | 00.09,79 I 66 11 11 |pronounced | 13 11 ] c linical | 11 11 11lver ( J1 11 | a ymp t onus ) | 11 11 1 1 J 00.00.21 1 4 1 4 1 15.10.63 | 28.08.80 I 59 24 257)2.79 High Autoclave worker Autoclave Worker I I 1 Ang 1 os a rtorna Iconf i rraed. |Annua 1 report |uf the Nortli | Rhine | Uestphal la [Medleal I Inspectorate (for 1978 Ipages 147-377 Iglves full (details. Vinyl Ichlorlde (disease Id lagnoaed 102-02-73. | Oesophageal [varices. I Sadlologlea I Iy (confirmed aero (osteolysis. "TF 22.02.60 Yea High Autoclave \ Dr Besche Metaataslng Worker [letter of ASL [13-04-82 to (Dr V C F Adams l 13 19.10.80 Yes High Autoclave | Dr Besche Haemangio Worker [letter of Endothelloaa | 11-04-82 To of liver with | Dr W U F Ad dint> Metaetaaea I 18 1 13 |19.06.60 1 Yes | High | Autoclave I 1 \ IHaenanglo [ [Worker and 1 J 1 | Endotheliona l Iworked In 1 i t |of liver with | Idrying shop 1 1 1 IHetastasea | 1 1 | Dr Hear lie 11ette r of | l 3-04-82 to | Dr W G F Adams 1 11 11 1 19 1 1 l |06.12.81 1 Yes | High |Autorlave |Chargehand, | Dr Besche Hetastas tng subsequently | letter of ASL Foreman | 3 M14-82 (u [Dr W C F Aii dins P.lgO I 'j GERMANY Sheet 6 I Cl CHEMICALS 6 POLYMERS LIVER Ang I osarcoma Cases ( Rev Date: i Jan 1989) Wrx/ASI. - l.ANOHH'AM-s, 20 12 I 3 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE Of FIRST VC BIRTH COMPANY JFACTORY EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTO LOGICAL CONFIRM-1 AT I ON ESTIMATED EXPOSUftE LEVEL OCCUPATION OTHER CAREER H ICHLICHTS OTHER COMMENTS CERMANY 100.00.27 26.03.79 52 1969 t 11.10.82 "54 29.09.81 28,05.83 High Cheal at ry (*300 pp) Worker High Autoclave (*300 ppm) Cleaner Primary hepatocellar card noaa; proliferation of the slmislodai celts with sinusoidal ectasia. Friedel letter 23.12.86. ^rof Eder ^Munich) letter 22.08.83. Friedel letter I9.04.B5. 100,00.23 100.00.22 8 t I960 28.09.01 50 13 High Polyclave Uorker and Autoclave Cleaner 22 22 22.11.82 Yea High | Polyworker Prof Selmalr (Munich) letter 22,08.83. Friedel letter 19.04.85 Chronic hepatitis, angiomatosis, sinusoidal ectasia. Friedel letter 23, 12.86. 27 28 I | I J l l 1 1 1 l \ 1 l 100.00.20 1955 55 | 2 1 11.23 | IS 11 11 11 !1 \1 \1 11 11 11 1I 11 100.00.22 ~r ~~7~ | 01.10 60 1 11 11 1 1l 1 11 l1 11 11 11 1i 11 11.08.85 l 1 1 i I i t i i i i i I 61 High Autoclave Cleaner till 1972 25 1 25 125 00.85 | Yes 1 High |Process | 1 111 |worker 1947-| i 111 1 11 1 184 <01.10.601 1-31.03.84 | 1 11 1 11 1 i 11 l 111 |PVC product-1 lion, t Jagltator \ \ area). | i 1l1 1 1 i 1l1 ! 1 i 111 r i l l11 i i 1 1f1 i i High Lei bach. Friedel letter 19.04.85 |Annual VCM screening |24,04.85: no complaint, |no abnormality detected. |1970 two-thirds (gastrectomy for ulcers. (1971 Coronary thrombosis |1983 Femora 1 1 1 rap 1 antat ion JI984 Pulmonary embolism Jand pleuropneumonia. (Landers letters 18.09.8*^ land 04.02.87, 1 Friedel letter 23.12.8b. 100.00.17 07,01.80 25 25.05.83 High Polyworker |Sh1ft leader HaeroangE osarkoma. Friedel letter 23.l2.rtb. 6 J]953 30.06.85 |An toe I avc |c]eaner Haemang(osarkuma. friedel letter 2 3.J2.Hti. 00.00.30 30 jAlive? | Po I yworker | An tiK'1 ave :]eaner J Itaema ng I us ,i rkoina. |friedel letter 2 ).I2.Hb. 0OSH5 Page HM Y I (i J C t t.HKM 1l A3.S t. I'Ol.YMt KS L. 1VKK Anglos at < oma t-K.es - (Review Slate: \ Jan 1969} Wl'X/ASl. - l ANi.HH-ASI-S 1 COUNTRY AND REFERENCE NO TTALY 02 (On NIOSH supple mentary list) NAME OR INITIALS DATE OF BIRTH 15.06.34 COMPANY PANSAC HI ra Venice JO FIRST VC EXPOSURE DATE OF DIAGNOSIS 19.04,71 ACE AT DIACNOS IS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH 16.04,71 HISTOLOGICAL CONFIRMATION ESTIMATED I EXPOSURE t OCCUPATION LEVEL \ J _____ ___ I J jPVC Bag (extruder OTHER CAREER HIGHLIGHTS OTHER COMMENTS Primary tumour may have been pericardium. Not homo geneous with other cases. 13.11.29 Mooted Ison Porto [Hsrghera J 3.J2.72 43 14.03.20 Soivay 10.07.75 10.07.75 20.07.37 C Dane sin 19.03.37 PANSAC 1 Ravenna 1J 11 11 11 1 00.04.59 | 00.01,61 lt 11 11 11 1i l1 1f 11 11 r1 1 1 1 1 1 1 1 1 1 l 1 1 1 1 1 | Hi ra [Venice 11 11 11 lt 11 I 00.00,67 [ 07.03.83 J1 11 11 l1 1 1 1 1 1 1 1 1 1 1 43 46 1 11 1 [1 1i 1 iI 21 1 21 1 30.03.01 J 1 II 1 1I ( 1j 1E 1 1i 1 1i 1i 1 1i 1 1I 1 1s [ 1i \ 1i J 1i 1 1i ! 1i 16 t 0 106.04,03 i 1 1i 1 1i l \i 1 1i See Maltoni Med dl Lavoro 65 p445, 1974, .Further details in letter from Dr Montebdno ** Also ha1 Million! and Riuul l lie M a in Aria Oncologic a Vo l I I9H0 pages 35 - 49. lARC on A|ri l 1st 1982. Yes Yes 1 j Polyworker J I I High |Autoe leaner 1972-5 did [8 yrs (1953- a variety of |6l) Autoclav jobs 1 Joperator [ Including S l |12 yrs (1961 PVC packing 1 172) 1 1 | I2 yrs - II yr1 Very High I Monomer E (operator I 5 yrs - t |Never cleaned |autoclaves. (See paper by JCHIAPPJNO et 1 1 1 1 A* |Non-smoker. | Medium [20 yrs - |a 1 Med Lavoro |Consumed 1 | 4 yra - 1 Autoclave (operator & IVol 6 ( 1982) Jpp 555-563 E1 it t Je |alcohol. No 4 Low lot her duties | AOL. I | 1n suspensJ | Ion polymer- 1 1 1 | lsation. 1 1 1 1 1 1 J Med iuni-1 IHigh 1 l 1 [Area Foreman |ln same Dept |si nee E 97 5. ( 1 1 Bag ext ruder j 1967-1975 (Commercial (Dept 19 761 196) 1 1 1 1 1 J S Pag]ta!ungn | te lex of [2 Aug t9Hl 1 1 Page 11 ITALY M....... l ELI CHi-Kf L iW,'> 4 FlfLYHhK'j LIVER AnglosarLoma Cates - (Review Date: 1 Jan 1989) Wl'X/AM AN(. UK A'iI . 13 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH FIRST VC EXPOSURE DATE OF DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OP DEATH HISTOLOGICAL ESTIMATED CONFIRMATION EXPOSURE OCCUPATION LEVEL i OTHER CAREER HIGHLIGHTS OTHER COMMENTS ITALY 06 2 k.06 - 36 Hon ted Ison Porto 01.10.60 Marghera, Venice 06.12.85 49 25 09.02.25 Hoplef an 1950 21.01.86 22 05.04.86 High 1960-7 J Medlua 1971-74 Low 1975-85 PVC aanufacture N years aa Autoclave cleaner 1960-71. 14 years In Control Roob J971-85 _L J 9 58-7 4 High 1974-80 Me dim Maintained VC Machinery (not operating or cleaning autoclaves) VC levela reduced froa 1973/74 Letters fro* Dr Chlozzini, Venice, 22.09.87 and 11.01.68 tnforaat ion froTM La aedJcina del lavoro, Italy, Vol 79 No.I Jan-Feb 88t and Dr Benetta, EnlChea. Edge JAPAN Jti Cl CHEMICALS & I'UI.YKERS LIVER Angiosarcoma Cases - (Review Date: I Jan 1989) WPX/ASL - LANClOCASES.? 1 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH ToaoJ1 Nor l 01.08.22 Mi tsul Toatsu Nagoya 02.08.39 Xanegafuchi Osaka Cheat cal 01.09.30 Hi tsul Toatsu Nagoya FIRST VC EXPOSURE 00.04.53 00.11.58 00.07.65 DATE OF DIAGNOSIS 24.10.75 10.08.76 26.06.85 ACE AT DIAGNOSIS 53 YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH 24,10.75 13 10.08.76 14.09.85 HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION PVC Assoc 13 yrs au says not c lave known, c leane r * Japan 1964 - Times assigned to 1ndicated d l f ferent on 25.10.75 work since exposures had 111 often at health 3000 ppm up to 1974 In polymer isation work Including autoclave c leaning High 5 years Autoclave c leaner OTHER CAREER HIGHLIGHTS I I I | j 1 OTHER COMMENTS ______________ 1 I |Japan Tiroes 125.10.75 & (Japanese PVi 1 Assoc lettei lot 31.03. 7R. 130.11.87 I I 1 \ (Japanese PV< j Associ at Ion (letters of 131.03,78 & |30.11.87 I_________ (Letter from j Dr Nakamu r d | Japanese PW |As hoc 1 at kon | JO.11.87 I_ NC 008148 Page 19 NORWAY ICI CM EH ICAI.S A POLYMERS LIVER Anglosarcotaa Cases - (Review Date: 3 Jan 1989) WPX/ASL - LANC[OCAbE5,24 I COUNTRY AND | REFERENCE | NO f NAME OR INITIALS DATE OF BIRTH j COMPANY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH I HISTOLOC1CAL | CONFIRMATION | | ____________________ 1 ESTIMATED EXPOSURE LEVEL J | OCCUPATION | i I I OTHER CAREER HIGHLIGHTS | j | | OTHER COMMENTS | AH 23.12.15 f NorBk Heroya 00,03.50 21.12.71 Hydro 04.01.72 High Foreaan & Autoclave supervisor | | | I | I I | I t i | 1 I 1 | Con f 1 nued by |Dr ThiialEvansen of NH. AC APHE Mtg of |9 June 1978 [Hr P Rangnes Fatated Chat AH |had been a jeeaber of a Istart-up teao. | VCM & PVC were I nade In same Ibullding. The |VCM was made Ifroon acetylene 008149 t Page SWEDEN 20 ' ICI CHEMICALS 6 POLYMERS LIVER Angiosarcoma Cases - (Review Date: I Jan 1989) WPX7ASL - LAMGfOCASES,2 5 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION I I ESTIMATED | EXPOSURE | OCCUPATION LEVEL | _______________ 1 f OTHER CAREER HIGHLIGHTS | 1 OTHER COMMENTS 23.06.27 14.08,51 20.10.70 00.01,45 00.08.72 61 00.05,4? 18.03.76 65 20.10.70 l | Polyworke r High | VCM |produc tIon High t )Polyworker I |Mr SJoelin'b | lect er of 1 28 March 197b [confirms BL | wa s a monorne r [worker who was | heavily [exposed, Iprobably even |more so t ban [a nnrnai | reactor |c leaner J___ ___ 1 04 | AL 1 1 1 ! 1 1 1 1 l 1 1 fJ M6.11 14 | Xetsanord 11 f1 11 11 11 11 f1 11 11 ff 1( 11 tt |Sundsvall[ (1 t1 11 11 J1 11 11 1\ tf !t 1I 1 00.00 46 | 1 1 J 1 1 f 1 f 1 1 1 1 1 J2.05.77 ( 1 1 f 1 1 1 1 t 1 f 1 f \ 1 Sundsv all 1l.05.64 62 1 1 1 1 1 3] 1 11 1 31 112.05 77 t J 11 1 l1 1 J1 1 11 l ) I 1J 1 J1 1 11 \ 11 I 11 1 fl 11 1\ Yea 1 l High \ i l 1 1 1 1 1 1 1 1 1 1| 11946-1958 | [polymer- | jisation | (worker (12 1 lyrsj 6 1958-J 11977 foreaan| 1(19 yra) | [| 1| )| 1| 1[ High 6 Years Low 10 Years, [ 1964-1970 k ent r(fuge [operator I 1970-E980 [drier Inperator I 1 1 n f 1 rs t 12 lyrs of [employment had [been heaviJ y lexposed. In 1 1 974 T liver [abnorma ] 1 t y J a nd tiec rcii lb [d lagnobed. [Data ronf1rmed | E n f> r D H y r e i s Metier I 8 . H . 7 7 [to CEP 1C 1 I [letter til | 2nd Hov J 4 | 1 S rom I Dr Ibiv I ,i Kyi , 1 J n Ills kuei of J s t April I9H2, Or of IARC says (n Sweden's National Boanl of trS Health gives 20-02-70 .iw d-ile of <11 .ignot, I j, for f.r.e hi amj jj'O'j ti [or Crise 02. 008150 2Cl CHEMICALS & POLYMERS i I WPX/ASL - LANGIOCASES ,2o UK Sheet ! LIVER Ang l onjim ijibji t ihch - (Kcvlt'w PuM-: l Ian L9H9) l1 COUNTRY AND REFERENCE HO \ 1 3 UK 1 lI ( l NAME OR | INITIALS 1 J 1 1 i 3 DATE OF BIRTH 4 COMPANY 11 1 5|6 11 11 1 ) FUST VC | FACTORY | EXPOSURE f/ 11 11 11 DATE OF DIAGNOSIS 8 ACE AT DIAGNOSIS 9 10 1 k 1 YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF l DATE OF EXPOSURE | DEATH 1 12 1 1 1 HISTOLOGICAL 1 CONFIRMATION | / 1 1 1 1 13 1 l ESTIMATED k EXPOSURE k LEVEL ) 1 I (4 OCCUPATION 1 I 1 ) 15 OTHER CAREER HIGHLIGHTS 1 ( [ 16 OTHER COMMENJS 01 |^j 02 03 | BJ W 04 t JSR |2Q.04.01 1 1 1 i l 1 1 1 1 1 1 1 1 102.06.37 1 1 l 1 123.06.20 1 1 l 1 1 1 1 1 J 1 1 1 ( \ 11 1 1 1 1 1 1 1 1 ICI BP ICI IHlllhouse| 04.04.44 1 i i 1 t 1 1 1 1 1 1 1 1 t Barry 1 i i 1 1 1 1 t 1 k 1 k 1 | 00.02.66 11 t1 11 11 1HliIhouaeJ 26.04.54 11 11 1l 11 1k 1! 03.12.72 (Pox 4 Collier pajver says 21.12.J2) 00.12.74 00,06.79 it t1 ii 11 11 k1 11 k1 1l 11 11 i1 1t 1f 11 71 37 59 20 22 103.12.72 Yes | 500 ppa 11944-7 VCH |Lee and Harry 1(Fox & 1 |1947-8 Drier| (Lancet |Collier Spaper laaya 1 11948-61 i |Autoclave 1 loperator (29-06-74 (pages 13(6-8 123.12.72)1 t 1J961-66 1 1 Drier tt 1 1I |Dub Lous 11 ]f abr LeatIon 11 lease 1 ! 09 3.5 124.12,74 Yes | High kAutoclave 1 Exposure 1 |cleaner 11imited to (1 12.66 - 9.69 11 lk 25 18 112.10.79 Yes I Medium- 154-5 |Pre-war fish 1 high (Bagging 1 packer I 1 Plant |1939-45 army 1 155-6 Ivehicle 1 IDrler Plant (maintenance 1 156-58 1 1945-54 l !Autoclave | fish packer 1 (worker ; 158-61 i | Chargehand t (Drier i 1 Pi ant s 161-72 i | Fo reman k |C 2/3 Plant It l1 I1 1f i1 if i1 if ii Page ZZ UK. Sheet 2 COUNTRY AND REFERENCE NO UK OS NAME OR INITIALS DATE OR BIRTH 30.03.14 1931 2^ .04.20 08.05.24 Barry Barry Barry Barry 1CI CHEMICALS A POLYMERS ,11WPX/ASL - LANCIOCASfc'S LIVER A.igloaarccnaa Cases - (Review Date: 1 Jan 1989) 7 i s i 5 i nr 15 FIRST VC EXPOSURE 1962 1965 DATE OF DIAGNOSIS 00,10,79 09,01.80 00.00.80" ACE AT D1ACNOS IS 65 48/9 60 YEARS OF EXPOSURE TO DIAGNOSIS 28 nr YEARS OF EXPOSURE DATE OF DEATH 21 19.J1.79 12 09.01.80 5,66.66 HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE l OCCUFAITON LEVEL | 1951-52 J Polycleaner t1952-55 (Latex |1955-60 IPolyfloor |1960-64 I Poly JChargehand 11964-70 | Charging | ope rat or 11970-72 |Drier loperator (Tyrs |Poly Floor (Operator 15 yra (Greaser on fPoiy Floor J Poiycleaner 11963-5 f Recovery |1965-1971 OTHER CAREER HICHLICHTS DlllER COMMbNIs 27.11.81 tr TT 25.12.81 1$50-1958 500 ppm 1968-1974 200 ppa I _____________ 1 1950-51 |Autoclave loperator | 1951-1957 iChargeaan lautoclave Ibulldlng 11957-1974 |Shifc |supervisor 1938-1948 Motor Mechanic 1948-1950 Operator on Acetylene ProductIon Plant lautoc Lave Ibulldlng (Never (cleaned j autoclaves | but \aupe rvisor *s | Job enralled (entering Jautoclaveb (to Inspect (then I _____________ fan* UK Shet`1 1 COUNTRY AND REFERENCE NO UK 09 NAME OR initials E1CF DATE OF BIRTH 07,05.25 COMPANY Barry 04.04,47 Barry 1 n i CLP i i I i i 1 i i i ( 1 1 1 11 |08 05.28 I BP t1 11 11 11 t} 1i 1i 11 1f Ii 1l 11 11 24.01.37 IC1 1 j Barry 1 1 1 1 1 i 1 1 ( 1 l 1 1 I Cl 1,`HEHI CALS A POLYMERS WPX/ASL - LANCIOCASES,IS LIVER Angiosarcoma Cases - (Review Date: 1 Jan 1989) FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIACNOS1S YEARS OF EXPOSURE TO DIAGNOSIS iO YEARS OF EXPOSURE DATE OF | HISTOLOGICAL DEATH j CONFIRMATION I1 ESTIMATED EXPOSURE LEVEL I | OCCUPATION | | 15 OTHER CAREER HIGHLIGHTS 15.02.50 02.03.63 5b 33 29 24.02.83 Had In Polywurker 12 yearn on I Acrylonlrri le |Resln Plant. fAlao prior to J1950. 4 years J RAF (maintenance. | 3 years riot or |car palntshop. |2 years In |Cravtng Dock. OTHER COMMENTS 27.04.66 OJ 05 84 37 4.2 16.05.84 High - 11 I Polycleaner jHeavy goods tenths (500 1966-67. |vehlcie drlv ppo). Low- Spray-drier |uatil final 18 months (50 pp). bagger 1967--|lllnes. 68. | Medina - Blow-down 1 21 months stripper | (200 ppa) operator ( 1968-70. 1 Inforteat 1 u given In letter 16.06.84 f Dr D M J Williams *5 f 1 f 19. 12.65 1 02.06.85 l 57 1 <9 11 1 1 11 1 1 11 1 1 11 1 l 11 1 11 1 ! 11 l 1 iJ 1 1 1t 1 1 1t 1 1 {1 l l 11 1 1 11 1 1 16.09.57 03.06.85 1 11 | 16 102,06 85 | 1 i1 1 t1 i 11 1 11 1 11 i 1i t1 t 1t l 11 I 11 i il l 11 I 11 06.12,85 Yes ) IHigh 11965 -69 |Ked 69-79 ILov 79-82 1 1 1 1 1 1 1 l 1 1 I 11 IPolycleaner f- 11965-68. | |Service | loperator | 168-69. I 1 Poly (Operator | \ 169-79. 1 | Leading Hand| 179-82. I 11 11 1f 11 Low 1957-59 Spare nan, High 59-74 bagging Low 74-85 floor 1957-59. Autoc Lave Operator 1959-85 1 |Letter of 104,06.85 (Dr Paul Smttt (and letter ot (04.06,85 (Dr D H D Evai |Oesophageal |haemorrhage |due to [oesophagea1 Ivarices due t [Angiosarcoma lof liver ( Let ter 26.06.85 Dr F I Let* TI * SENC 008153 lJ.K'* 74 uk Sheet 4 ICI CHEMICALS & POLYMERS LIVER Angiosarcoma Cases - (Review Date : I January 1959) WpX/ASU I.AN(. HH ASJ s , H \i 1 11l 11 1f i 1 12 | 1 1 4 1 5 16 | 1 I a 19 1 10 | 1 t 12 in i 14 1 IS 1 | 1 1 COUNTRY AND (NAME 11 1i OR ( DATE OF * l1\ 11 ii i * i* 1 YEARS OF i 1 |RISTO- i \ 1 (FIRST VC 1 DATE OF |ACE AT JEXPOSURE |YEARS OF J DATE OF jLOGICAL |ESTIMATED) OTHER 1 1 | REFERENCE |INIT1ALS| BIRTH 1 COMPANY [ FACTORY I EXPOSURE |DIAGNOSIS |DIAGNOSIS j TO |EXPOSURE! DEATH |CONFIRH-|EXPOSURE | OCCUPATION CAREER | NO \ | 1 11i |DIAGNOSIS | i I ATION |LEVEL t HIGHLIGHTS | 1\ l 11i !1 11 1 1 11> OTHER COMMENTS UK n 14 15 16 1 HJ i \ i 1 1 1 1 1 ! |CS t 1 J i 1 | | 1 1 1 | BCP | | I l ( 1 t | RT | 102,03.48 |BP 11 i1 11 11 11 11 11 11 i1 1 15.06.42 |BP 1i 11 |I lI I1 II J| 1 1 1 123.08.21 I I 1 1 1 | BP I I !1 |I 1 1 1 l 25.05.22 1 1 1 1 ICI | |I l 11 1 11 1 lit III Ill III III 1i 1 | Barry | I960 | Jan 86 1 i i1 i 11 t 11 1 11 1 11 11 1 i1 1 1 (Barry 107.07.66 i 1 127.08.87 1 i i 1 ii 1 1i \ 11 1 11 1 i1 1 i1 1 11 1 1 1 |Barry | 1956 1 1 1 | 1988 1 1 1 1 1 1 1 J 1 1 1 (HIllhouse ( 1963 I i 1 1 1 1 1 1 | 1988 1 1 1 1 1 1 1 1 l 1 I 11 1 11 I 1I | 1I 1 li 1 1i [ 1 11 | 11 1 1 11 1 | 11 1 | | |1 1111 37 45 66 66 i 1 i 1 1 l 1 1 1 18 3 1 ) 1 1 1 1 21 11 i 1 1 1 i 1 ) 1 1 1 32 1 16 1 1 1 1 l ! 1 25 1 12 1 1 1 J 1 1 1 1 1 1 I 1 1 (02.06.86 f 11 11 11 11 11 11 I1 i1 J1 101.12.88 | ii 11 l1 Ii ii ii ii Il Ii lI i oi.05.set ii ii ii ii 1E 1E 11 1 12.1 l .881 11 J1 11 ii j1 11 f1 11 11 11 11 11 11 Yea Yea Yea Yea 1 High 1Polycleaner t 1 1968-69 | Low I Cent ral 1 | Depot 1 11969-70 1 High I Polyfloor 1 |1970-1971 t 1 |Moved to |Remained well, working |AcryLonltrile jactlvely, until Jan 1986 |Plant until (left BP 1983. |Manager of |1C 6 SS Ltd at |Cardiff Airport| |1963-86 110 months IPolycleaner IHlgh |1966-67 |10 years 1 Poly floor Iconstant 1 worker at tlmes| (Medium |between |but on |inter- | 1968-1982 Imittent 1 Jobs 1 1 19 years 1 High |5 years | Medium |2 years 1 Low |Poly cleaner 6 1 Operator ^Exposure |Blow 6 Recovery ^periods jOperator M nteralt tent lUtlllty |Operator 1 \ \ i year ) 1 Packer t Low ) |9 years) 1 High ) \2 years) !Autoclave 1 Operator 1 Lo ) 1 1 1! 1 11 1i 1 1 11 ! 11 1 11 1 |Letters from Dr DKD Evans, |Pathologist, Penarth, Wales land Dr DHJ Wll llama, BP, Barr t (Information from |Dr D H J Vltllans, 8P, and |Dr Paul Smith, Pathologist (9 IHepatlc fibrosis 1974 |0esophageal varices |Porta-caval shunt 1975 (Information from Dr B Bennett |ICI, and Dr F [ Lee, Blackpoo IVictorla Hospital 1968. 1 ! 1 1 1 1 SENC 008154 USA Mi.'rt I n ICI CHEMICALS & POLYMERS , [ VHK Ajih i aw ;i r r (Hr view jj.it c: 1 -Jan 1989) UK jjyiili'i* if <Li(1h DAY - MUNI II - YKAH I3 UPX/ASL - LANC1GCASES,29 COUNTRY AND REFERENCE NO NAME OH INITIALS DATE OF BIRTH Earl Pa rks 17.10.23 19.08.33 1 03 | Edwa rd |25.05.15 BFC |Dinwiddle 1 1 1 04 1 1 \ J15.01.24 1 BFG l1 1 05 1 1 125.01.12 BPC 11 11 1 06 (Ray 1 123.11.28 BFG Aust in Jones? 07 Charles 03.05.22 T Smart FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE At DIAGNOSIS YEARS OK EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OK DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS Louis ville 09.J2.48 03.03,73 Louis ville IS.11.55 00.05.70 37 1 |Louls| ville 1 1 1 |Louis| ville 1 1 | Louis| ville 1 1 |Louis- 1 1 28.11.45 l 1 1 1 | 06.07.52 1 1 1 | 19.06.44 J 1 1 1 17,01.62 19.12.73 19.08.67 09.04.64 00.02,74 1 | 1 1 * l | 1 1 1 1 1 1 1 | 58 43 52 45 S Charle ston 27.08.44 00.00,68 03.03.73 27.09.71 (NIOSH says 28.09.71) 1 ii 1 28 | 28 119.12.73 | Yes | 1 11 1 1 1I 1 1 11 1 1 l1 1 15 1 15 107.01.68 f Yes | 1 t1 1 1 J1 1 1 l1 1 20 t 20 f09.04.64 | Yes | 1 11 1 1 \1 1 l f1 1 12 \ 12 j 24.07.75 J Yes | 23.03,68 Pot Cleaner (Block Jana 1974) p S3 I History given |Rolling Stour In Annals NY |Art ACAD SCIENCES |Ref 1 NY Acad Vol 329 (1979) |of Sc Sytap page 190 in |1974 Paper by |Also Block B R Cot tine of|Jama 1.7.74 OSKA |p 53 ________ I Pot Cleaner (Cf Block) \ f Pot Cleaner |Loulsv 11le J(Cf Block) {Courier 1 | Journal 1 102-09-80 1 IPot Cleaner 1 (Cf Block) l i 1 Pot Cleaner ucf Block) 1 11 IUS Air Forcej Pot Cleaner (Cf Block) JRef 1 (Also Block jJAMA 1.7.74 ip 53 f | Ref } Also Bl ock 1 |Ref | Also Block r j Ref | Also Block +| Ref 1 | Loulsv lilt? |Tines 23.7.7C IRetlred April 11974 |Also Block I I Ref 1 06.05.20 Goodyear Niagara 07.10.46 | Ref 3 GENC 008155 Kige ih USA ...... } 1 l i 11 I M J < ftl s'. t'ui.rnf n:i LIVER Angj im.it cornu Cases - (Kcvii;w Date; l Jan 1989) UK system ol drileti DAY - MONTH - YEAR WPX/ASl,_2 - LANClOCASt S, l COUNTRY AND REFERENCE NO NAME OK INITIALS DATE OK BIRTH Raynond GettleKi nger? 08.11.31 Louis ville FIRST VC EXPOSURE DATE OF DIAGNOSIS AGE AT DIAGNOSIS YEARS OK EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER I f OTHER CAREER | COMMENTS HIGHLIGHTS ,| ___________________ I__________________ I 26.05.45 01.03.74 29 24 11,03.75 2000 ppn t |Ref 1 has |wrong figures |re first lexposure. |Loufsvi1ie |Tines |29. 10.74 , 112.3.75, i10.3.76 16.08.13 Goodyear Niagara 12.06.51 00.05.66 27,05.09 Goodyear Niagara 14.10.46 00.03.70 55 17 10.05.68 16,03.70 | Re f 1 I________ 1 j Ref 12 Francl9 A 17.11.18 Bachman Pottstown 13.07.49 Pa 50 Rlcha rd Edua rd Clendenln S Charle ston 11.12.42 00,05.74 52 19 02.05.69 26 07.04.74 High 10 yrs 10 yrs as reactor op. (not cleaner - separate crew cleaned autoclaves) Utility 6 Service op. Bagger Dryer op. Stripping op. 3 yrs prior service In tyre plant (Ref I + let t e |of 26 April ( 1978 f ruin |Russel 1 A Par \t o J T Sea we l |of MCA I I _________ 2000 ppm (Charleston | Da My Ma i 1 121.7.75 I |Neve r dlag |nosed as ang(losarcooiri of (liver. Iniorm j at loti given [ | let ter 2 2 May | 1964 f run |J A Salg. J |Account ant ; |ASL - No evi dence of V(.M |e xpos u re. GENC 008156 TV Pafre USA Sheet 4 28 ICC CHbPt 1t Al b f> POLYMERS LIVER Angiosarcoma Casts - (Review Date: Jan 1909) UK system of dales DAY - MONTH - YEAR WPX/ASL 2 - LANG E0CA5E5, S 23 COUNTRY AND REFERENCE NO USA NAME OR 1 DATE OF INITIALS BIRTH 4 15 6 COMPANY FIRST VC | FACTORY i EXPOSURE i i 7 l8 DATE OF DIAGNOSIS AGE AT DIAGNOSIS 9 YEARS OF EXPOSURE TO DIAGNOSIS 10 YEARS OF EXPOSURE 11 DATE OF DEATH 1 12 HISTOLOCICAL 1 l 1 | CONFIRMATION | 1 ( 1 13 ESTIMATED EXPOSURE LEVEL 14 | OCCUPATION l 1 t { 1 1 9 15 OTHER CAREER HIGHLIGHTS 16 OTHER COMMENTS 22 |02.10.23 BFC l Louie- 11.07.47 00*01.76 52 29 23 24 (25) | Charles | Edwa rd 1Hoore 1 9 ) | t I i 1 I I 1 1 | l | 1 1 } 1 00.00.23 Great American Chemical Fitchburg 08.09.58 Hass. 06.04,73 15 tl7 05.17 1 UCC 11 11 1l 11 11 1| |1 |1 11 1 11 11 11 11 || 1( || 11 11 1 Remova1 from IS Charle-| 1539 1 27.05.77 | 60~ 1 aeon | 1 1 1 11 1 1 11 1 9 1t 1 1 11 1 1 *1 1 I 11 1 I 11 1 I 11 1 1 11 1 1 11 I 1 11 1 1 11 1 1 11 1 1 11 l 1 11 1 1 19 9 1 1! | 1 11 [ i t1 1 1 reg Ester confirmed in K KamInski letter of 5 Novemher 38 I9bi) 28 04.12.76 Yes f 14 06.04,73 -ouisvil le Tines 26.1.7b said he was the 10th AS victim at Bells Lane of whoa 8 had died by 26.1.76 In his letter of 16,09.81 Dr H N Johnsot conflnu this Is the case describe! by Dannaher Tamburro 6 Yn in Teh 1980 An J Med ic ine Vol 70 p280 i 74? KNTGSH Isays 26) 1 1 ) 1 i 1 9 i 1 t 1 1 1 1 i 1 ] 1 1 127.05.?? /Cholanglo1 |sarcoma t 1(8 Kaminski 1 1 26/2/79) 1I 11 t! 11 11 1t 11 11 1f 11 i1 1i )1 11 !1 1l 1i 1i 1Medium to (high for |24 yre 1 1 1 1 9 1 1 1 1 1 i 1 i 1 1 1 t l f 11941-65 non -|1937-39 was / N H Wheeler |solvent |off and on /letter of /vinyl resin |labourer | i8.fi.77 to /unit and 1 1939-41 may |J Stafford /dispersion (have been /gives detait ^ |vlnyl res ins/exposed as /Rose Kaminski (unit first /reactor | letter of |as fitter /cleaner 1 26/2/79 /helper, then|1943 became |R Kaminski /shift /shift fitter 1(5 Nov i980) |uti11ty man |1946 became /suggests thai 1 /shift utility | NIOSti wl 11 1 | man /retain on 1 126.04.65 Iregister s i n< 1 /employment was (this neoplasr 1 |terminated [may be assoc 1( fated wltt) AS' 11 |R N Wheeler 19 |let te r of 1 1' /20/ 2/ 79 a ml 11 iRose Kamin.sk 11 Itetter:. ot 26/2/ 79 SENG 008158 Si \ 1/00 Page 29 {;tbrM .t Cl CHEMICALS 6 POLYMERS I.IVER Aiigh>H.m odji Canes - (Review \)M t': I Jan I 98 9) UK system of dales NAY - MONTI! YEAH UPX/ASL_2 - LANGlOCASE S t 4 1 I2 13 COUNTRY AND 1 NAME OR | DATE OF REFERENCE f INITIALS | BIRTH NO USA 4 COMPANY 1 3| 6 7 11 i i FIRST VC | FACTORY | EXPOSURE DATE OF DIAGNOSIS 11 ii t 26 IJobn Berry 107.07,23 BFG 1 i 1 |Louis|vi1le i 1 1 1 1 | 03.10.47 | i 1 1 1 1 00,00.77 (up to 2 years after death) 1 l i i 27 |J L | 11.03,16 UCC |Forrest 11 11 \1 ii ii ii 11 ii i |S Charle-J 01.07.4[ 30.11.78 | eton | 11 ii ii i ii I1 ii 28 111.04.17 UCC |S Charle-| 00.08.44 03.11.78 ( ston | it 29 |12,10.07 i UCC |S Charle-| 00.05.42 00.03.B0 | ston | jt 30 1 VVN ii |22.07.22 1 Tenneco |Flea!ngton 11.06.64 Chest cals 1 l 30.12.80 ii 1f ii ii 1J 3) 108.11.23 UCC |S Charle-l 12.05.46 01.08.81 | ston | ii 11 11 1 JJ ii 1j 11 11 !1 t 'I t1 j 11 i 1! 8 ACE AT DIAGNOSIS 1 9 1 10 b J 1 YEARS OF | YEARS OF i DATE OF EXPOSURE TO j EXPOSURE | DEATH DIAGNOSIS 1 1 11 12 1 13 i 14 1 it HISTOLOGICAL { ESTIMATED | ( CONFIRMATION | EXPOSURE | OCCUPATION | | LEVEL | | 11 15 OTHER CAREER HICHLICHTS 1 1 1 | J I i 16 OTHER C0HHENT5 52 28 1 18 | 11.02.75 Yea (Exposed In |Various Jobsf JR Kaminski (death) (death) 1 |soae degree|In PVC f lletter of ! | to 22 Iplants from | 126/2/79 and 1 Ichemi cals (cold rocm to| |Prof. Tautbu 1 |but main Ipaste [ lletter of 1 (exposure Irecovery to | |9/ 1/79 11 |was to VCK |PVC charging f ( 11 11 11 |probably |high | opera tor to | Ipaste I Icharglng. | ( I 1 1i Jill August | 1 i1 11965. | | JJ |Ternlnated | | t (employment | | i 62 * 37 1 f 20 | (N10SH |25.11.78 (Jan 1966 \ 1 Yea ( High (Operator to (Exposure in |R H Wheeler 110.10.76 {bulk and | 11 r of U J.ii Isays 27 J (dispersion PVCj1979 and land C | (manufacture |Charleston |Dally Halil 11 (Dally Mai 1 125) 11 | 30. 1 1.78 an. 1 11 \ R Kamlnsk l 1 61 34 1 33 (03.11.78 Yes 1j 11 I 26/2/79 LR Kaminski 1 11 (letter of 11 1 16/4/79 72 1 36 1 1 1 58 1 1 1 18 101.03.80 1 1 ii 1 13 1 30.12.80 1 Yes 1 1 1 1 Yes 16 - Unknown (Maintenance f9 - Mlninal |Mechanic (R Kaminski [Letters of j 1 9t h June 11 | 5th Nov ! 1 1 JJ j 6 y rs lElsewhere I 1 1i 1 1) yrs | 1 11 IBoiler housel I 11 (Operator 1 i 57 i 35 1 1 13 102.04.82 |9 yrs 1 Yes | High (But iChenlcal |Frona 1959 to |Dr Dacey l1 (not as high lOperator in ( 1976 A1 lphattc\letter l1 !1 11 las reactor (charge jcleaner Ireactor (wool d | (Chemicals (16.10.81 and (operator and J R N Whee1er (from July I976|letter of 1 1\ J1 11 11 11 Jexperience)1 |Worked as | |labourer \ 1f rom | |June 1941 l |to date |Foreman lAliphatic Chenlca L |Opera cion |9.11.8 L. |Also Dr Dace lletter of 107.03.83 re (date of deal 1 J1 11 | to May 1946 1 land nay 1 1 1 f1 11 | have |c1eanud 1 1 1 1t ,i | realtors In E \ r 00815? Page a:,a Sheet h 30 1U I, t VKM Angli t CALS 6 POLYMERS f k.M (Lite: I Ian I VH4> UK RyMem of dales DAY - MON Ml - YEAR WPX/ASL i - UNtlOCASKS.i COUNTRY AND REFERENCE NO 32 33 34 33 36 1 Ii |3 l i | NAME OR | DATE OF | INITIALS | BIRTH 1 1 1 |C u Giroux |22-02-08 I | | | 1 1 1 l 1 I 1 1 1 1 1 1 I 1 1 |S Ferguson 108-10-27 I Jnr 1 I | 1 1 |Hr Byrum 129-01-34 | 1 | I 1 1 1 1 109-03-12 i 1 1 1 127-08-32 | 1 1 I | 1 1 1 i 1 ll 1 4 1516 t 1 1 | COMPANY ;| FIRST VC | FACTORY | EX POStfRE 1 1 1 | Monsanto i l l i i l l l i l i l i i l l l ! 1 j BFC ;| ii Sprlngfleld | Hass I | | I| I| 15-10-51 it 11 I1 ii || 11 11 ii j1 |1 jj || || I1 |Louisvl1le 09-09-54 i l 1 1 1 1 ( BFC 11 l| 1| 11 (Loul6vilie 1955 1 i1 1 l1 1 1j i 11 \ l 1 I ucc l l l JS Charle-| 23-07-44 Jston 1 t I IThe Ceneral |Ashtabula! 11-06-56 (Tire and |Robber Co 1 | 1 1 1 11 1 1 1 |7 1 1 | DATE OF j DIAGNOSIS t t 1 | 00-07-79 1 1 1 1 i 1 1 1 1 1 1 1 1 1 i 1 1 1 1 | 11-05-02 1 1 1 ! 1 ! ! 03-11-82 1 1 1 1 1 1 1 1 18-07-83 1 1 1 1 1 121-08-83 1 1 1 1 1 J 1 1 1 i i 1 1 1 1 1 1 1 I l 1 1 1 1 H ACE AT DIAGNOSIS 71 i 54 48 71 50 l1 9 1 10 1 l ( 12 | 11 1 E4 J 15 1 16 J1 1 1 YEARS OF 11 | YEARS OF | DATE OF EXPOSURE TO | EXPOSURE | DEATH 1 H1STQLOGICAL I ESTIMATED CONFIRMATION | EXPOSURE | OCCUPATION OTHER CAREER 1 | OTHER ( COMMENTS DIAGNOSIS i 1 1 ! | LEVEL 1 HIGHLIGHTS 1 1 11 1 28 i u | 17-05-80 An autopsy jThe death | 1940-1951 Kin PVC 1 was done and |cert Iflcate{Various Jobs |sutoclave 1 Immediate Igave |in polymer \ a rea} i cause of |Mr Giroux' |Manufacture i1 death given |usual 1BUTVAR 1 1 ae (occupation |LUSTREX 1 1 "Angiosarcoma"l as "kettle|1951-1964 11 loperator" IVarious Jobs 11 | In |In and 11 | "cheat cals {around PVC 11 | lndust ry". ^autoclaves 11 1 |1964-1973 11 1 |Various 11 1 |c lerlcal 1i 1 |jobs In PVC t1 1 |polynerlsat Ion 11 1 Ifacllity/ I1 1 |Ret 1 red II I 101-03-73. T | Information (given In lletter of 24 |February 198 |froo Dr |Ua)ter C | Ba rnes of (Monsanto | SprlngfieId l Dr A Munn of (Monsanto |Europe. 1 \ 1 1 ! 1 I E1 28 1 28 | A1 lve Yea 1 j |Hultiple t (Prof Tarabum 11 1! 11 1\ 1\ 1 11 27 1 10 J04.08.83 1 Yes l1 11 11 1 l1 11 11 39 E 14 118-07-83 Yes 11 11 11 11 1i 27 1 27 j Alive Yes 11 11 11 11 11 i1 i1 i1 it i( I 1 J obs E l includIng 1 \ Poly ( (Operator + 1 (Polycleaner. J | | Poly ( (Operator + 1 |Autoclave 1 |Cleaner t 1 1955-65. 1 1 1 |High from |1944 to |1955. J Medium from j 1955-1950 1 IModerate 1 1 1 1 1 1 1 1 1 1 1 1956-56 | labourer 11956-57 (prod helper J 1957-70 (operator 11970-75 |e lect r l <_ tan 119 75-present |operat or (letter of I 12 Aug L 99 2 | Dr M N Johns. lletter of 128 Feb 1983. 1 J 965 left BFC (Dr M N Johnsi to become a (letter of Clergyman. | 3 Nov 1982, (28 Feb 1983 land 9 Aug 11984. 1 1 |Dr Dacey lletter of |5 Sept 1983. 1 1 t |R W Lauiulrte lletter of 11 2 Sept 1 9tJ3 Ispotted at |medical |Ha y 1983. (Tes t tng |comae need |Ma y 1983 1 1 GENC 008160 Page 31 USA S k h i> i I ill CHEMICALS 6 POLYMERS ` LIVER Ajig I ojj j rc (mo tldaeb - (Review Date' I January 1989) WPX/ASL2 - LANClOCA^LS.b UK bystem of iluU'.s DAY - MONTH - YEAR 1 ii 1 1k 11 1 1 1 L f 2 1 3j 4 t8 1 1 1 H t9 1 J" 1 i 1 1 1 1 1 14 1 k5 1 ih COUNTRY AND REFERENCE 1t 11 (NAME OR [ 1 INITIALS! 1 DATE OF| BIRTH | i11! _J____________ J J____ EJ |YEARS OF 1 IHISTO- | i [FIRST VC IDATE OF j ACE AT 1 EXPOSURE | YEARS on DATt OF |LOGICAL [ESTIMATED! (OTHER COMPANY | FACTORY | EXPOSURE |DIAGNOSIS!DIAGNOSIS (TO EEXPOSUREI DEATH ICONFIRM-IEXPOSURE |OCCUPATION f CAREER 1 i 1 | OTHER COMMENTS NO 1 1 t 1 t [DIAGNOSIS! 1 IAT10N t LEVEL (HICHLICHTSE \it 1 t 1 \ \ 11 1 E1 USA 37 38 39 1 | Mr J | Payton ii |29.08.291 BEG || 1 | Ixiu 1b- |vi 1 le 11 1 11 1 11 1 1 i1 1 1 11 t 1 E1 t 11 j 1k 1 1 [JWB 1 1 J 1 128.06.22|Air | (Products 1 1 1 [Calvert IClty 1 l J1 \i 1 1 1k 1 1 11 11 1j l 1 1 1 1 11 1 1 1;; E 1 1 1 |J Hemice 127.06.J81Pantasote |Passaic |f 1 11 !k i |f 1 [1 1t 1 1 1 |1 1 \ |1 1 [j ! Ii j f 1 |1 1 |1 1 E | 1 1 11 I1 1 [\ 1 11 111 1 j | 1953 I I 1 | | | I k j 100.02.63 1 1 l I | 1 | | | ! 1 1 E E | 1 I960 I | 1 f J i \ i 1 j j i [ E E 1 1 i j 1 1 1 106.08.84 1 1 1 1 1 1 1 1 1 1 |19.01.84 1 1 1 1 1 ! 1 1 1 1 1 1 1 1 1 | March 11984 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 j 1 1 1 1 | | | 1 | | | J | 1 | | t 1 l | | | | | | | 1 1 1 1 | 1 1 1 1 1 1 1 1 1 1 1 I 1 1 1 1 1 1 \ 1 1 54 61 65 11 II 1 31 | 22 J06.08.84 | Yes 1 High |Worked 1 [Information given In letter 09. OB,B4 t1 | regularly 1 [from Dr M N Johnson 11 jin FVC areal 1 1i Jin the I | 11 learly days ! 1 11 | was a | I 11 | reactor | | 11 Icleaner | | 11 1 11953-75. ] f 11 i 11 1 IThrombo cytopenla and leukopenia since | 20 1 20 |28.10.63 | Yes 1 High |Normal | Islnce 1978. Cold treatment for arthritis t 1 1 |I963-I982fprogreeslor11 11976. Under Dr's care about 6 months 1 i1 1 I frtn helper! Ibefore death, had passed standard physical 1 11 |to Benior I (examination 3 months earlier. J Barr 11 loperator, J [letters of 22.10,84 and 23.01.85. 11 |cleaned | [ 1 11 Ireactors, 1 i 1 11 1 1st ripping 1 1 11 1 land 1 1 11 E Irecovery 1 1 11 1 late as as E 1 11 1 |we11 as f 1 J1 E [charging ! 1 11 E [operator. 1l 1f 11 | (Never in hospital for any chronic or J 24 | 23 E 29.06,84 | Yes j Lou 129.09.60 - | Worked lacute medical problems. Death certificate k1 | Hay 66 |bef ore (states cause of death cardlo-pulmonary 11 |Vinyl 11960 larrest secondary to angiosarcoma of 11 E | Fabrl cat ionj wi th US |1iver. 11 \ |Plant |Air ILetter of 15.07,86 from John E Ertel 1 f 1 High | Hay 66 - [Force, |of Pantasote with letter of 24.02.H6 1E |Aug 70 [United (from Dr Auerbach, Pathologist. 11 E lUtlllty |Wool 1 1 11 |Resin | Dyers 1 1 1i (Operator land 1 1 1 1 Jflnc Jul 66|Okanlte 1 E Ei |- Sep 67 J k 1 11 IReactor 1 1 1 \1 [Ope rater) | f [ 1 1 | Low I Sep 70-82 | J 1 11 |Monomer | ( 1 11 {Operator 1 ! 1 i 1 | Low 1 19 82-83 1 1 1 1 (1 | Ml J1 1 1 1 1 f [ (Operator, J 1 [ 1 t 1 |Calendar 1 1 t 1 f 1 | Shop , unt111 1 t 1 1 1 j ret It euicni 1 < 11 1 GENC 008161 USA Sliroi H tCl Ciifc-M[CALS & POLYMERS LIVER Auk*"Harr* -n - (Review Date: J January I989> WPX/ASU LANG lOLAHl- S ,, i UK t.ystL'ui of dates DAY - MONTH - VhAK 11 1 12 1 l1 1| COUNTRY AND (MAKE OR j REFERENCE | INITIALS! \ 31 ( 1 DATE OF| BIRTH | 4 COMPANY NO 11 1 USA 40 1 i 1P P |Gilmer 1 f !} ti 126.10.(41 |1 II \1 BFC 1 || 11 1 1I 1 1 11 41 |R Buckley 2.02.LSI Goodyear ! t| L 1\ ( 1f I| I| | Ii || | || 1 11 1 11 1 1 |5 1 1 \ | FACTORY 1 1 i (Louis'|vllie 1 I I 1 1 1 INlagara |Falls 1 J 1 I 1 ( \ 1 \ I \6 i 1 |FIRST VC 1 EXPOSURE 1 1 i 122.05.42 1 1 1 1 1 1 ! 1 1949 1 1 ! 1 ! 1 1 \ ( i f 111 1 7 t 0 j9 (10 I i ( 1 |DATE OF |ACE AT 1 1) IYEARS of t 1 |EXPOSURE IYEARS OF| DATE OF | DIAGNOSIS (DIAGNOSIS (TO |EXPOSLfRE| DEATH 1 IDIACNGSISI ( ! 1 11 i i i1 I 1987 1 72 | 45 j 34 I03.0J.B7 1 1 11 1 I 11 1 1 11 ( 1 11 i 1i \ J (1 t 1 1 11 1 1987 1 72 l 38 1 27 (20.08.87 1 1 11 1 1 11 1 1 i1 1 l l1 J 1 l1 1 1 11 t 1 11 1 l \J 1 t1 1 1 1l 1 (t 1 1 13 J4 1 35 I 1l fHISTO- t ( 1 i |LOCICAL J ESTIMATED) (OTHER |CONFIRH-]EXPOSURE IOCCUPATION |CAREER | IATION |LEVEL |HIGHLIGHTS) (6 OTHER COMMENTS 1 1 j Yes 1 1 1 1 \ 1 1 | Yes 1 1 j 1 1 ! I J 1 1 1 ii | High |Chenleal 1 1942-1974J Worker 1 |1942-45 J Low )1975-19761 Foreman | 11945-76 i i i f 1 1 1 1I 1 | High M949-65 | Retired t (Chemical Op/ 1977 1 (Shift Sup/ 1 (Age 62) ( (Foreman, t | |PVC Resin 1 J (Production 1 [ MedluB (1965-77 ( | |NF Plant 1 ||Left PVC area for 6 months | In 1965) 1 1 1 1 |Letter froa Dr Dietz, BEG, (10,3.87 t ILettere f roa Prof Tatnburro (University of Louisville, 1967 (and Dr C A Johnson, Goodyear, 1988 WPX/ASL2 LANG LUGAbta , XU GENC 008162 J*d*e M YUGOS LAV IA 1C I CHEMICALS f, POLYMERS LIVtK Angl oearetnsa Cases - {Review Date; 1 Jan 1989) WPX/ASL - LANClOCASES,33 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH COMPANY (3 15 YEARS OF FIRST VC DATE OP AGE AT EXPOSURE YEARS OF EXPOSURE DIAGNOSIS DIAGNOSIS TO EXPOSIIRE DIAGNOSIS DATE OF DEATH HISTO LOGICAL CONFIRM ATION ESTIMATED EXPOSURE OCCUPATION LEVEL OTHER CAREER HIGHLIGHTS OTHER COMMENTS YUGOSLAVIA Jugo Vinil Split 00.00*53 08.04.73 59 20 08 .04.73 SAR1C et al paper Env Health Perspective Vol pp 189-192 1976 17. 02 15.1l.31 Jugo Split 00.00.50 12.07.73 42 Vinil 18 12.07.73 VCH Production Mn his letter of 3 Oct 1978, Dr Splrtae of NIOSH changed the status of Case 02 to VCM production employee. Dr Sptrtas also notified a new Case 03 also a VCH productloi worker. 03 l 1 1 1 04 1 1 |21. L2.3M Jugo 1 |Vinil 11 11 |11.06,301Jugo J (Vinil tSpllt | t 1 ISplit ( 104.06.541 1 1.01.76 1 11 l 11 1 11 1 115.12.58103.09.7B 1 11 1 45 l 1 1 1 48 1 1 22 20 22 ( II.01.76 1 Yes* 1 11 1 11 1 I i1 IS 103.09,78 | Yea \ 1 11 | VCH |Production 1 i i i 1 1 1 1 1 1 1 1 1 1 | Rose Kaminski letter of 19 June (t ARC letter of I April 1982 i960 and 1 11 Page 34 Incidence of ASL Cases Per Annum TABLE 1 (Review Date - 1 Jan 1989) By date of death 1955 ................................................................................................ 1 6 ..............0 7 ................................................................................................ 1 8 ......................................................................... ...................... 0 90 1960 ................................................................................................ 0 11 2 ........................................................... I 3 ................................................................................................. 0 4 ................................................................................................ 2 5 ................................................................................................. 0 6 ................................................................................................ 0 7 ................................................................................................ 1 8 ................................................................................................ 5 9 ................................................................................................ 3 1970 ................................................................................................ 2 1 ................................................................................................ 3 2 .................................................................................. 5 3 ................................................................................................ 8 4 ................................................................................................ 5 5 ...................................... 11 6 ..................................................................................................11 7 ................................................................................................. 9 8 ..................................................................................................10 95 1980 ..................................................................................................10 1 ................................................................................................ 5 2 ............................... 3 3 .................................. .............. ,............................................10 4 ................................................................................................ 7 5 ................................................................................................ 6 6 ................................................................................................ 5 7 ................................................................................................ 3 8 ................................................................................................ 4 Total 137 N.B. 1 Does not include Italian 01 but does include German 03. 2 The 1977 total includes US case 24 which is a Cholangiosarcoma. 3 Does not include Lhe following who are still alive, so far as known: I* r I *>, 22, 21 4 24, G31 4 32, U,333 & 36. Page 35 Distribution of ASL Cases by Country tTaAIbJflj.l-i: 2 (Review Date - l Jan 1989) USA W Germany France UK Canada Sweden Italy Yugoslavia Japan Czechoslovakia Belgium Norway 38 *** 31 ** *** 25 *** 15 13 5 kkkk 6* "kkk'kk 3 2 2 l Total 145 * Omit ItOl - atypical case of PVC bag extrader. ** Includes G03 aerosol can filler. *** Includes case US 24 which was diagnosed as Cholangiosarcoma; & Frl5, 22, 23 & 24, G31 & 32, US33 & 36, who are still alive, so far as known. **** Includes one monomer worker. ***** Includes two monomer workers. i.e Western Europe North America Rest of World 85 51 9 Total 145 WPX/ASL2 - LANGIOCASES,10 REUr. 003165 Page 36 Pattern of ASL Cases by Factory TABLE 3 (Review Date - 1 Jan 1y89) (a) W Europe Of the 85 cases in W Europe, 73 have occurred in clusters at 12 factories. Of the 3i German cases, 28 have-occurred in clusters at 4 factories. ASL Cases Dynamit, Troisdorf, Germany BP, Barry, UK Wacker, Burghausen, Germany Atochem (formerly Chloe Chimie, formerly RP), St Fons, France Atochem (formerly PCUK) Brignoud, France Kemanord, Sundsvall, Sweden CWH, Marl, Germany ICI, Hillhouse, UK Solvay, Tavaux, France Lonza, Waldshut, Germany Solvay, Jemeppe, Belgium Atochem, St Auban, France 12 1l 9 9 8 5 4 4 4 3 2 _2 73 NB: There are 32 pre 1962 PVC plants in W Europe; 19 of these have had ASL cases (Ref Table 8) (b) N America Of the 51 cases in N America, 42 have occurred at four factories out of a total of 55 factories. In N America 42 plants have not had ASL cases. ASL Cases BFG, Louisville, US BFG, Shawinigan, Canada UCC, S Charleston, US Goodyear, Niagara Falls, US 15 12 10 _5 42 NB: There are 29 pre 1962 PVC plants in N America; 13 of these have had ASL cases (Ref Tables 9 & (c) Rest of World The 9 ASL cases are believed to be in one cluster of 4 and two clusters of 2 cases. WPX/ASL2 - LANGIOCASES.il I'age 3/ TABLE 4A (Kuv i uw Date - I Jan 1989) Latency Periods (Years from first Exposure to Diagnosis) Count ry No of Cases Total Years Average W Europe Belgium 2 35 17.5 France 25 689 27.56 * Germany 31 632 20.38 * Italy 6 127 21.16 Norway 1 22 22 Sweden 5 122 24.5 N America UK US 15 350 23.33 * 85 1977 23.25 38 993 26.13 * Rest of World Canada Czechoslovakia 13 M 2 314 1307 30 24.15 * 25.62 15.0 Japan 3 59 19.66 Summary Yugoslavia W Europe 4 9 85 85 174 1977 21.2 19.33 23.25 N America 51 1307 25.62 Rest of World 9 145 174 3458 19.33 23.84 * * Of the countries with 10 cases, France, USA & Canada have an average latency period above world average; Germany & UK below world average. rmv/inn t GiEENC^ 00Si 61 DISTRIBUTION OF LATENCY PERIODS TABLE 411 (Review Date - 1 Jan 1989) i1 1 1 1 1 1 11 1 1 1 1 I 0-9 yrs 1 10-14 yrs | 15-19 yrs [ 20-24 yrs | 25-29 yrs ] 30-34 yrs I1 1 1 1 1 11 1 1 1 1 11 1 1 1 1 ( Belgium 1 | Canada 1 1 1 1 Czechoslovakia 1 1 | France 1 1 1 21 1 1 11 1 31 ! 51 2 1 1 !i 1 1 1 [ ii 1! 1 1 i1 1 1 1 1 i i 41 31 91 3 | Germany 1 1 1 1 11 1 5I 9[ 10* | 3I 2 | Italy | Japan | Norway I Sweden | UK I | USA | Yugoslavia | TOTAL 11 11 11 11 1 l 11 11 11 | 11 11 11 11 i1 I1 11 |11 1t i i i i \ 1 i i i i i 21 1 1 1 1 12 | 1 i 21 1 1| 1 \ 1 21 1 51 1 7| 1 1 1 ! 33 I 1 1 21 1 2! L l1 1 1 1 1| 1 91 1 41 1 1 37 | 1 i 21 1 1 1 1 21 1 51 [ 81 1 1 1 1 33 | t I 3 5 15 * Includes G 03 aerosol can filler 1 1 11 1 1 1 1 1 Average | 35+ yrs 1 1 Total 1 1 Latency | 11 1 1 Period 1 1 1 1 1 (Table 4A) | !1 1 1 11 2 11 17.5 | u 11 2 11 13 1 1 24.15 | 11 1 1 f1 2 11 15.0 | 11 1 1 5 11 25 1 1 27.56 ] 11 11 11 31 1 1 20.38 | 11 1 1 1 11 6 11 21.16 j 11 1 1 11 3 11 19.66 i I1 1] 111 1 1 22 | [1 1 1 1 ii 5 11 24.5 | 11 1 1 i 1 15 i 1 23.33 | 11 1 1 7 i 1 38 1 1 26.13 1 11 1 1 1 11 4 11 21.2 | i1 11 f11 1 1 14 11 145 1 1 23.84 I i1 11 1 WPX/ASL2 - LANGIOCASES,13 GENC 008168 TABLE 4C Page 39 (Review date 1 January 1989) LATENCY PERIOD OF A5L CASES TABULATED BY YEAR OF FIRST EXPOSURE | MAX POSSIBLE I YEAR OF ] 1 LATENCY PERIOD I FIRST EXPOSURE ) 1 11 LATENCY PERIOD (NO OF YEARS) 1 ARITHMETIC MEAN 1 1 OF LATENCY PERIODS 1 1 1 49 I 1939 | 38* 1 1 48 1 47 1 46 1 45 1 i i 1 1940 I1 12 13 14 1 15 16 1 I 37,21,37,41 1 1 I 32,38,45 1 1 38,14,32,42,45*** 1 | 28,11,24,20,24,34,39 > 1 j 44*** 1 1 27,22,28,29,37 1 I 21,29,31,26,28,15,23 289 = 8 886 31 36.12 28.58 1 I 1 | I 1 i 1 1 30,35 i 41 1 7 1 29,24,29,28 i 40 i 8 1 28,24,34 1 1 1 1 1 1 i 1 9 I 30,26,20,38 1 559 25.41 | i 1 1950 I 26,22,31,19,23,14,33 1 22 1 i I 1 1 19,28,17,28,34,29 1 i 36 1 2 I 21**,15 1 i 35 1 3 I 25,22,23,22,20,31,22 1 1 1 i 1 | 32*** 1 1 i 1 4 | 21,21,25,25,21,28*** 1 1 i 1 I 22 1 849 22.94 ! i ( 5 I 22,23,24,14,19,21,27 1 37 1 i 1 | 27*** 24,28,30*** 1 1 i 1 6 1 21,12,27***,32 1 i 31 1 7 I 19,17,15,13,16,28,30 1 I 1 t 30 1 8 I 18,18,15,17,20,29***28 1 i 1 9 I 16,21,25,27 1 598 19.29 I i 1 1960 I 13,18,21,25,24,25 I 31 1 i 1 1 | 15,16,16,16,19,19,12 1 1 i 26 1 2 1 13,18,17,12,18,21,26 I i 25 1 3 I 16,17,20,21,25 1 1 1 i 1 4 1 16,17 1 246 17.57 1 i 1 5 1 11,19,20 1 14 1 i 1 6 1 9,18,21 1 1 i 21 1 7 1 16 1 1 i 20 1 8 1 18 1 1 i 1 9 ! 13 1 1 1970 1 \ 1 1 31 12 1 15.5 1 1 VIOLA 1 i 16 1 2 1 !1 i 15 1 3 1 i 1 MALTONI 1 41 i 1 GOODRICH i I TOTAL | 145 CASES i 3458 = 23.84 1 i11 i 145 1 ! * Cholangiosarcoma L- ** Aerosol can filler i*** The following are still alive, so far as known, Frl5, 22 , 23 & 24, G31 and 32, US33 and 36 PPX/ASL2 - LANGIOCASES,14 GENC 00816? TABLE 4D Page 40 (Review dace 1 January 1989) LATENCY PERIODS OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL "" LOCATION ~ "------- MAX POSSIBLE I YEAR OF 1 LATENCY PERIOD 1 FIRST EXPOSURE | LATENCY PERIODS IN WESTERN EUROPE 1 NORTH AMERICA 1 49 1 1939 ! 1 I 38* 48 I 1940 1 47 1 1 1 37,41 1 21,37 46 1 45 1 21 3 I 38,45*** 1 32,38,45 1 14,32,42 1 4 1 28,44*** I 11,24,20,24,34,39 1 5 I 27 I 22,28,29,37 1 41 1 6 1 21,29,31,33 7 I 29 I 26,28,15,23,30,35 1 24,29,28 40 1 8 I 28,34 1 24 ' 1 9 1 30,26 1 20,38 1 1950 1 26,22,31 I 19 1 1 1 19,28,34,29, I 17,28 36 1 2 I 21** 1 15 35 1 3 1 25,22,22,32*** I 23,31 I 4 I 21,21,25,25 | 21,28*** 1 5 I 22,23,24,27***24,28 1 14,19,21,27 1 | 30*** 1 6 I 21,12,32 1 27*** 31 1 7 1 19,17,15,13,28 1 30 30 1 8 1 18,18,29***28 1 15 1 9 | 16,21,25,27, 1 I960 1 13,18,21,25,25 1 24 1 1 I 15,16,16,16,19,19 1 12 26 I 25 1 2 1 13,18,17,18,21,26 1 12 3 I 16,17,21,25 I 20 1 4 1 16 1 17 1 5 1 11,19 1 6 1 9,18,21 21 1 7 I 16 20 1 8 1 18 1 9 1 13 1 VIOLA 1970 1 2 1 MALTONI 3 1 TOTAL CASES I ] 1 1 85 | 1 51 1 ROW | 1 | | | | 1 1 1 1 1 1 1 1 23,14 | 1 1 I1 22,20 1 22 I 1 1 1 1 16 | I 17,20 I 1 1 1 1 1 1 1 20 1 I 1 1 1 1 1 1 1 19 1 * Cholangiosarcoma ** Aerosol can filler *** The following are still alive, so far as known Frl5 22, 23 & 24, G31 and 32, US33 and 36 WPX/ASL2 - LANGIOCASES,15 TABLE 4E Page 41 (Review date I January 1989) PLANT LOUISVILLE USA TROISDORF W GERMANY SHAWINIGAN CANADA BARRY UK USA I START I UP I DATE I LATENCY PERIODS OF ASL CASES IN SPECIFIC PLANTS (10 OR MORE CASES) NO OF | AVERAGE CASES | LATENCY PERIOD i i 1940? | 1 J 1954 i 1 1 1943 | (1941?)| 1948 1) | 1 1 1939? | i 12,14,15,19,19,20,24,27,28,28,28,29,29 31,45 12,13,16,16,18,19,19,21,23,25,28,29 11,12,14,21,22,23,24,24,26,28,42,37 9,17,18,28,31,33,18,19,18,21,32 24,30,32,32,34,35,37,38,38,39, l 1 1 1 1 1 1 1 1 1 1 1 1 1 15 12 12 11 10 1 1 1 1 | | 1 I 1 1 1 | 1 | 24.53 years 19.91 23,66 22.18 33.99 pX/ASL2 - LANGIOCASES,16 GENC 00317 Page 4 2 TABLE 4F (Review date 1 January 1989) LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPECIFIC PLANT (LO OR MORE CASES) YEAR OF FIRST | LOUISVILLEI EXPOSURE 1 USA 1 1939 1 1 1940 1 1 TROISDORF W GERMANY | SHAWINIGAN | | CANADA | 11 11 BARRY UK 11 1 1 21 1 21 1 31 1 4 I 20 1 5 . 1 28,29,27 1 1 1 14,42 1 11,24 1 22,37 1 1 1 1 6 7 8 9 1950 1 1 ! 29,28 I 24 1 1 19 1 1 1 1 1 1 1 29 1 26,28 ' 1 24 ! 1 1 | 1 1 ! 1 1 31,33 I 28 2 1 15 1 3 1 31 1 4 1 28 1 21,25 5 1 14,19 1 23,28 61 I 12 71 I 13 81 1 1 1 23 ! | | I 1 1 1 1 1 I 32 1 1 9 1960 1 1 1 1 11 I1 1 16,16,19,19, I 12 1 1 1 2 1 12 31 41 1 18 1 1 | 1 1 1 18 1 17 1 51 61 71 1 1 1 1 1 19 1 1 9,18,21 11 8 9 1970 1 1 1 1 1 1 1 1 1 1 1 18 11 1I 11 21 1 11 | S CHARLESTON | USA | 38 1 1 37 I 32,38 1 32 1 24,34,39 1 1 30,35 I 1 1 1 1 1 1 1 1 1 1 1 1 I 1 1 1 1 1 1 1 1 1 1 1 1 WPX/ASL2 - LANGIOCASES,17 GENC 003172 Page 43 (Review date l January 1989) TABLE 4G PLANT START-UP DATE LATENCY PERIOD OF ASL CASES | NO OF IN SPECIFIC PLANTS(4-9 CASES)| CASES AVERAGE PERIOD BURGHAUSEN W GERMANY ST FONS FRANCE BRIGNOUD FRANCE SUNDSVALL SWEDEN | I 11 | | | 1 | | | 1 I | I NIAGARA FALLS USA | 1 1 SPLIT | YUGOSLAVIA! 1 MARL | W GERMANY | TAVAUX FRANCE HILLHOUSE UK 1 | | 1 1 | | 1933 1939 1950 1945 1947 1950 1948 1953 1940 1 17,21,22,25,24,13,21,32,30 1 9 1 22.77 years 1 11 1 11 1 21,28,29,37,38,27,41,34,44 1 9 1 33.22 I 11 1 11 I 11,16,18,26,30,25,34,45 1 I 8 I 25.62 11 1 11 1 16,19,27,29,31 1 1 5 I 24.4 11 1 11 I 15,17,21,23,38 ! 1 1 20,20,22,23 1 51 1 22.8 I1 11 1 4 I 21.25 11 1 11 1 15,16,22,21 1 4 1 18.5 1 11 I 1 19,16,21,26 11 1 4 I 20.5 1 11 1 11 I 28,25,28,25 1 1 4 1 26.5 11 WPX/ASL2 - LANGIOCASES,18 008^73 GENE Page 44 TABLE 4H (Review date 1 January 1989) LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPECIFIC PLANT (4-9 CASES) YEAR OF iBURGHAUSENi FIRST EXPOSUREl W GERMANY! 1! 1939 1 I 1940 1 1 1 1 ! 2 1 1 31 1 41 1 51 I 6 1 1 71 1 8 1 1 91 1 1950 1 1 1 1 ! 2 1 i 3 125 ,32 | 4 121 | 5 [22,24,30 [ 6 1 7 1 17 1 I 8 9 1960 1 1 121 1 1 [ 1 1 2 1 31 4i 51 6 1 71 8I 9 1 13 1 I 1 1 1 1 1 1 I 1970 1 I 1 1 2 1 1 1 ST FONS FRANCE 37,41 38 44 29 28,34 27 21 1 *Monoiner worker 1 BRIGNOUDl FRANCE 1 ! 1 1 1 1 45 I 1 1 1 1 26,30 34 1 1 1 1 1 1 1 1 18 16,25 1 1 1 1 f 1 1 1 1 11 I 1 i 1 1 1 1 1 1 sundsvall! SWEDEN 1 1 i 1 1 1 27* 31 29 ! 1 1 1 1 1 1 1 19 1 i 1 1 1 1 1 1 1 1 ! 1 [ 16 [ 1 1 1 1 1 1 1 1 1 NIAGARA! SPLIT | fiARL 1 FALLS i YUGO-lw GERMANYl USA | SLAVIA| j TAVAUX FRANCE 15,23 38 17 21 1 1 1 1 1 1 1 1 i 1 1 1 23* 1 1 ! 20 *12 2 1 1 1 1 20 1 1 [ 1 i 1 1 1 1 1 1 1 1 1 1 1 | 1 1 1 22 I 1 1 1 | 1 1 [15,16 121 1 1 ! 1 1 1 1 1 I 1 i 1 i i i i i i i 19 i i i i i 26 116 ,21 11 11 11 11 11 1 1 1 1 1 11 [1 11 11 1I 1 1 1 I i 1 HILLHOUSE [ UK ! I 1 [ i 1 1 28 1 1 1 f 1 1 1 1 I 1 25 1 1 1 28 1 1 1 1 I 1 25 I [ i 1 [ 1 1 1 1 1 GENC 008174 CD Page 45 TABLE 5 (Review Date - 1 Jan 1989) Annual Incidence of ASL Cases (Date of Death) by Geographical Area 1955 7 1961 2 4 7 8 9 1970 1 2 3 4 5 6 7 8 9 1980 1 2 1983 1984 1985 1986 1987 1988 TOTAL 1f | Western Europe | 11 11 1 11 11 1 |1 1 |1 |1 ]1 14 I1 13 16 16 16 |7 I5 1 1 1 1 1 1 1 1 1 1 1 1 1 1 16 |5 1 1 |1 1 17 1 I5 ! 15 1 14 1 I[ 14 1 1 79* ** f i North America I 1 11 1[ 11 I1 11 1 51 21 11 21 11 41 21 41 31 31 21 -! 41 01 21 31 21 1 3 49** [ 1 1 1 l 1 Res t of World | 1 1 \ 1 1 1| 1 t 1 1 f 1 3] | 1| 21 1 1[ | | I 1 t 1 11 1 t 1 91 Annual Total 1 1 1 1 2 1 5 3 2 3 5 8 5 11 11 9 10 5 10 5 3 10 7 6 5 3 4 137 I Cumulative | 1 Total | Key Events 1 11 12 13 14 16 I7 1 12 1 15 1 17 | 20 I 25 1 33 I 38 I 49 I 60 1 ' 69 1 79 1 84 I 94 1 99 t 102 1 112 [ 119 1 125 I 130 I 133 I 137 1 1 1 1 1 1 1 1 1 1 | Viola 1 1 I Maltoni I Goodrich 1 1 ! 1 1 1 1 1 1 1 i 1 ! 1 1 * Includes GO3 aerosol can filler but omits It 01 bag ext ruder ** Does not include the following who are still alive, so far as known: Fr15 22, 23 & 24, G31 & 32, US33 & 36 1 1 Page 46 (Review date I January 1989) TABLE 6 ASL CASE NUMBERS BY YEAR OF DEATH AND GEOGRAPHICAL LOCATIONS (EXCLUDING It.01) 1 KEY | 1 EVENTS | | WESTERN EUROPE i 1 NORTH AMERICA 1 1 REST OF WORLD 11 1I 11 1 1 1955 6 11 1 17 8 11 1 19 1 1 1960 1 11 2 11 3 1 1 Cl 1 | C2 1 1 1 I US8 I C3 1 1 1 I 1 1 1 1 1 1 1 11 11 11 11 11 1 |Viola 1 | 11 11 IMaltoni | 1 Goodrich [ 4 6 7 8 9 1970 1 2 3 4 1 FI 1 G1 | Swl I G2 I N1,Sw2,UK1,112 I G3** I G4.G5.UK3 I US5 1 1 1 | C4,C5,US4,US7,US10 | US12,US16 i usi i | C6,US2 1 C7 | C8.US1,US3,US23 | C9.US13 1 Cz2 i 1 I 1 1 1 1 1 1 Y1 , Y 2 , Cz 1 1 1 1 5 t F2 ,F3 ,G6 ,G7 ,G8 , T.t3 | US6 ,US9,US18,US26 1 Jap 1 1 1 6 1 B1 ,F4,F5,F6,F7,Sw3 | USI9,US20,US22, 1 Jap2,Y3 1 1 7 | F8,F9,G10,G11,G12,Sw4 | C10,US21,US24* 1 1 1 8 1 F10.F11 ,G9.G13.G15 | US27 ,US28 1 Y4 1 1 1 G16,G17 1 1 1 1 9 I FI2,FI 3,UK4,UK5,G18 1 1 1 1 1980 I UK6, UK7,G19,Sw5,G20,G2lUS | US17, US29, US30,US32| 1 1 1 I It4,F14,UK8,G22,G23 1 1 1 1 2 I G26 | US31,Cl2 1 1 1 3 I UK09,It5,F17,B2,G24,G25,G30| US35, US34, US38 1 1 1 4 I UK10, F16, F18, G27.G29 | US37 ,US39 1 1 1 5 I UK11, UK12,F19,F20,G28 1 1 Jap3 1 1 6 I F21,UK13.It6,It7 I Cll 1 1 17 | US40 ,US41,Cl 3 I 1 1 8 I F25,UK14,UK15,UK16 1 1 Total 1 79*** 1 49*** ' 1 19 11 11 * Cholangiosarcoma ** Aerosol can filler *** Does not include the following who are still alive, so far as known: Frl5, 22, 23 & 24, G31 & 32, US33 & 36 WPX/ASL2 - LANG10CASES,21 GENC 00817 Page 47 TABLE 7 (Review date 1 January 1989) ASL CASE NUMBERS BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL LOCATION (EXCLUDING It.01) " KEY | EVENTS I 1 1 WESTERN EUROPE 1 1 11 1 11 1 1 1939 1 1 40 1 I 1 1 1 |Fr11,Fr16 I 1 21 | 1 3 |Frl4,Fr24*** I 1 4 |UKl,Fr23*** | 1 5 1 Sw2 | 1 6 |Fr 1 ,Fr3,Sw4 I 1 7 | Sw3 | 1 8 IFr9, Frl7 1 1 9 1Fr12 ,Fr4 I 1 50 I Fr7,N1,UK8,UK9 1 1 1 1Swl,UK5,Fr20,G30 1 1 2 | G3** I 1 3 1G15,It3,G26,G31*** | 1 4 |G7,G8,UK4,G19 1 1 5 I Gil,G16,G18, Frl5*** 1 1 (G23,G28,G32*** 1 1 6 IFR10.G1,UK15 1 1 7 |Fr8,G4,It2,G2,UK12 1 1 8 |Fr6,Bl,Fr22***,It7 I 1 9 |Fr2,It4,Frl9,Fr21 1 1 60 lG5,G13,G25,G28,It6 1 1 1 |G9,G10,G12,G17,G20,G22| 1 2 |G6,UK6,G21,B2,G29,Fr25| 1 3 1FrI3, UK7,Frl8,UK16 I 1 4 1 Sw5 I 1 5 |Fr5,UK11 1 1 6 IUK3, UK10.UK14 1 7 1 its 1 8 1 UK13 1 9 1 G24 Viola | 70 1 1 1 1 1 1 till l!2| Maltoni | 31 1 1 1 11 1 1 Total 1 85 1 11 1 NORTH AMERICA I 1 REST OF WORLD 1 US24* 1 1 C3,US27 I 1 US 13, US29 , !JS40 1 C2,US19,C11 1 Cl.C5.US5.US7,US28,US35 1 C4.US3.US9.C12 1 C7.C9.US8.US11,US21,US31 1 C6.US22.US26 1 US! 1 US12.US41 I US16 IY2, Cz2 US10, US3 2 1 IJS4 1 CIO, US37 USJ8.US33*** 1Japl,Y1 1 Y3 US2,US17,US20,US34 1 1 US36*** Cl 3 US2 3 1 I Cz 1 1Jap2,Y4 1 US39 C8 US6 U S3 8 US30 1 1 1 1 1 1 Jap3 1 1 1 1 1 1 1 1 1 51 19 ! * Cholangiosarcoma (US24) ** Aerosol can filler (G3) *** Frl5, 22, 23 & 24, G31 & 32, US33 & 36 are still alive, so far as known WPX/ASL2 - LANGIOCASES,22 6EMC 008177 Page 48 WPX/ASL2 - LANGIOCASES.23 (Review date 1 January 1989) TABLE 8 WESTERN EUROPE PVC PROttlCERS - START-UP DATES vs ASL CASES (OMITTING 003 & It.01) START-UP| COUNTRY NAME | COMPANY NAME I LOCATION I ASL CASE MM5ER | YEAR OF YEAR 1 1 1 I 1st Exposure 1931 |West Germany IRASF lUriwigshafen 1 1933 (West Germany |Wacker | Burgjrausen 104,07.11,15,23,24157,54,55,53,55,69,60,531 11 1 125,31,32 |55 | 1938 I Italy | Montecat ini |Acna 1 1939 I France (Rhone-Poulenc/ I Sc Fons 103,09,10,11,14 146,48,56,41,43, 1 |Chloe/Atochai'i 1 115,16,17,23 155,41,48,44 1940 1United Kingdom|ICI/EVC IRunoom (Closed 1948) 1 lUnited Kingdom|ICT/EVC !Hillhouse 101,04,12,16 144,54,57,63 1945 |&eden IKananord/Nobel | Sundsvall( Stockvik.) 10 L ,02,03,04,05 151,45,47,46,64 1946 |France |Rhone-Poulenc I Roussillon 101 |46 1948 lUnited Kingdom|BP Chem/ICI/EVC|Barry 103,05,06,07,08,09166,51,62,63,50,50 11 1 110,11,13,14,15 166,65,68,66,56 |West Germany |CWl/Huls |Nfarl 109,10,26,29 161,61,53,62 1949 IBelgium |Solvay I Jemeppe 101,02 158,62 1950 |France | PCUK/Atochan IBrignoud 102,04,05,06,12 19159,49,65,58,49,59, 11 1 120,24 151,43 |France |Rhone-Poulenc/ |St Auban 107,22 150,58 1 | Chi oe/Atochan 1 1 I Holland |Shell I Ftemis, Rotterdam 1 |Norway | Norsk IHeroya, Porsgrunn 101 150 1951 1 Switzerland 1952 I Italy ILonza/ICI/EVC I Sins (Montedison/ ITemi 107 I 158 1 |Moplefan 1 1 I Italy |Montedison/EVC I Porto Marghera 102,06 157,60 1953 I Austria I Hal vic/SoIvay (Hallein 1 I France ISolvay ITavaux 108,13,18,25 157,63,63,62 I Italy ISolvay I Ferrara 103 153 I Spain |Rio Rodano IHemanl 1 lUnited KingdcmlBXiyBIP/NORSK 1 Aycliffe 1 IWest Getmany IHoechst 1954 |West Germany IDynamit I Gerxlorf ITroisdorf 118 155 101,02,08,12,16,17156,57,54,61,55,61, 11 1 119,20,21,22,27, 30154,61,62,61,55,51 1955 I Spain I Monsanto Iberia IMonzon 1 1956 I Spain ICaiqsa |Sablnanigo 1 1 |Hispavic/Solvaj |Torrelavega 1 1958 IWest Germany |Solvay |Rheinberg 1 1960 I Italy |S C Raverma/EVC!Ravenna 104 159 (West Germany ILonza/ICI/EVC |Waldshut 106,13,28 162,60,60 1961 I Italy IMontedison/EVC |Brindisi 1 1962 1 Portugal ICires I Oporto 1 1965 |France | Rhore-Poulenc |Montlucon 121 159 I Italy IPozzi |Ferrandina 1 1 Italy | Bensac |Mira, Venice |05 167 IWest Germany IWacker |Cologne 1 1966 lifest Germany IHoechst | Khapsack(Frankfurt) 105* 160 1967 |France lAtochem |Balan 1 (Spain |Rio Rodano iMiranda de Ebro 1 I Greece |Esso Pappas IDiavata Salonika 1 1968 IBelgium IBadiphil |Antwerp 1 1969 (United KingdomlVinatex/Norsk IStaveley 1 I Italy IRumanica/EVC I Cagliari Sardina 1 Continued G&HC 008378 Page 49 Table 8 - Continued WESTERN EUROPE PVC PRODUCERS - START UP DATES vs ASL CASES (OMITTING G03 & It.01) |START-UP| COUNTRY NAME | COMPANY NAME I LOCATION | YEAR 1 1 1 | 1970 |Italy (SIR |Porto Torres Sar |United Kingdom|ICI/EVC |Runcorn | 1971 |Spain | Hispavic/ Solvay | MartoreU I Sweden | Karanord/Norsk |Stenungsund |United Kingdom!BP Chan |Raglan Bay | 1972 |Finland IPeksna ISvartback |Hoiland | DSM IBeek Limburg I 1976 I France |Soc Art D'vinylIMazirgarbe 1 1(CDF) | 1 1977 I Spain |Monsanto Iberia!Tarragona | 1982 |West Germany | TCI/EVC IVoslapp 11 | Wi lhelmshaven 1 ASL CASE NUMBER | 11 11 11 11 11 11 11 11 11 11 11 11 11 YEAR OF 1st Exposure * Laboratory worker in Research Department 1 WPX/ASL2 - LANSIOCASES,24 6EHC 00817 Page 50 (Review date 1 January 1959) TABLE 9 USA PVC PRODUCERS - START-UP DATES vs ASL CASES START-UP I COMPANY NAME LOCATION | ASL CASE YEAR OF YEAR 1 NUMBER 1st EXPOSURE 1939? |*UCC S Charleston 107,13,19,21,24, I 44 ,42,43,46,39, |27,28,29,31,35 141,44,42,46,44 | Dow Midland (made | Saran copolymer) | 1940? | *BFG Louisville 101,02,03,04,05, I 48 ,55,45,52,44, 106,09,16,17,22, 162 ,45,50,55,47, 126,33,34,37,40 1 47 ,54,55,53,42 1946 |*UCC/Dow Texas City (Partially closed 1977) 1947 I Goodyear Niagara Falls 108,10,11,20,41 146,51,46,55;49 1948 I Firestone/ Potts town I 12 I 49 I Occidental 1 | Uniroyal Painesville I (closed 1975) I 1950 I Monsanto Springfield I 32 151 (Closed 1975 1 1952 | Dow Midland (No PVC since c 1975) | BFG Avon Lake |18 154 1953 | Diamond/BFG Deer Park | 1954 | General Tire/ ** Ashtabula |36 156 1 DiversiTech (Closed 1984. Reopened 1986 by Vygen) 1956 I Air Products Pensacola (Pace) I | Atlantic Refining Brooklyn(Closed late 1960s) I Borden Leominster (Closed 1984) | Conoco Hebronville (Closed 1975) | BFG Niagara I | Great American Fitchburg 123 1 58 | Plastics (Closed 1983) I I Hooker Hicksville (Closed 1980-81) | Pantasote Passaic(Closed 1984) 39 |60 1957 I Atlantic Tubing Cranston (Closed 1967~5 | Tenneco/ Flemington NJ I 30 1 59 | Occidental (Closed 1985) I 1958 | Keysor Century | Air Products Saugus, Cal 1 Calvert City(Paducah) 38 1 63 (Closed March 1982 Re-opened October 1983) 1960 I BFG Long Beach, Cal (No PVC now. Formerly shown as Watson) | Borden Illiopolis Iv 1962 1 Tenneco/Occidental Burlington NJ I 1963 I Conoco/Vista Aberdeen, Miss I | Stauffer Long Beach, Cal (Closed 1982) 1965 I Conoco/Olin Assonet, Mass (Closed by Olin 1975) | Ethyl Baton Rouge (Closed 1984) 1966 I Diamond/Georgia Delaware City I I Gulf 1 |Gen Tire/Pantasote Mt Pleasant W Va |(Closed 1982) | BFG | Stauffer/Formosa Henry, 111 | Delaware City (Sold to Formosa 198 0 1967 | Allied/Robintech/ Painesville, 0. (No PVC made by Robintech. | Georgia Pacific GP converted to polystyrene) | Hooker/Occidental Burlington NJ I 1968 IFirestone/Occidental Perryville (Closed 1982) WPX/ASL2 - LANGIOCASES,25 Continued GEHC 008180 Page. 51 TABLE 9 (Continued) USA PVC PRODUCERS - START-UP DATES vs ASL CASES I START-UP| 1 YEAR I 1 1969 | 11 1 1971 | I 1972 | I 1973 | 1 1974 | 11 11 1 1975 | 11 11 11 1 1979 | 1! I 1983 | I 1986 | COMPANY NAME | 1 BFG | Goodyear/BFG | Conoco/Vista Nat Starch Borden Atlantic Tubing/ Tallyrand | | | | | Shintech Certain-teed Georgia Pacific/ Georgia Gulf I I I | Tenneco/Occidental 1 Firestone/ 1 Occidental 1 Formosa Vygen | ** 1 LOCATION | 1 Pedricktown NJ Plaquemine | | Oklahoma City Meredosia, 111 [ | Springfield | Cranston RI (Closed 1 Freeport, Tex Lake Charles ! | Plaquemine, La I ASL CASE NUMBER 1982) Pasadena, Tex | Addis (formerly shown as Plaquemine) | Point Comfort, Tex I Ashtabula, Ohio | I YEAR OF I 1st EXPOSURE 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 * My databank has no information on UCC before 1946 or BFG before 1950 ** Refer to same plant at Ashtabula, bought by Vygen from DiversiTech. NB Some of the plants in this list were closed down, some have changed ownership over the years, some have changed their product. WPX/ASL2 - LANGIOCASES,26 GENC 00S1S1 TABLE 10 (Review daCe 1 January 1989) CANADIAN PVC PRODUCERS - START-UP DATES vs ASL CASES |START-UP | YEAR I 1943 1(1941?) | 1951 | 1957 I 1966 1 1979 COMPANY NAME | LOCATION 1 | ASL CASE 1 NUMBER I YEAR OF 1 1st EXPOSURE 1 Goodrich | Shawinigan (Formerly Gulf) 1 (Formerly Shawinigan Chemicals) (Formerly Canadian Resins & Chemicals) 1 101,02,03,04,05 106,07,08,09,10 111,12 1 1 144,43,41,45,^4, 147,46,61,46,53 143,45 1 11 Monsanto I1 | La Salle (Closed 1975) 1 1 1 11 1 11 Goodrich | Welland (Niagara) 1 13 157 1 11 1 11 Esso (Imperial Oil) | Sarnia 1 1 1 11 1 11 Diamond Shamrock Alb/ | Fort Saskatchewan 1 BF Goodrich 1 1 1 1 WPX/ASL2 - LANGIOCASES,27 Page 53 (Review date 1 January 1989) TABLE 11 EASTERN BLOC PVC FACTORIES - START-UP DATES vs ASl CASES |START-UP | COUNTRY NAME | COMPANY NAME | YEAR |Pre 1939 |East Germany |State Company | 1941 |Russia (State Comps | 1950 |Yugoslavia IJugo Vinil 1 1951 1 Czechoslovakia |State Comps | 1955 |East Germany I State Comps 1 1956 |Rumania |State Comps | 1957 |Poland |State Comps I Rumania I State Comps | 1958 |Rumania |State Comps I 1959 I Hungary I State Comps I 1961 |Rumania |State Comps | 1963 |Yugoslavia | Ohis | 1965 |Bulgaria |State Comps 1 1967 |Poland |State Comps | 1969 |Russia |State Comps | 1970 1 Rumania |State Comps |Russia |State Comps 1 1972 I Yugoslavia IVinilplastika I 1975 |Czechoslovakia | State Comps |Russia |State Comps 1 1976 |Yugoslavia I Hip 1 1977 I Rumania | State Comps | LOCATION 1 ISchopau (Vladimir et al |Split |Novaky ,|Bitterfeldt |Icechim lOsweicim (Dwory) |Tirnaveni |Turda |Risnov |Berente Borsod |Borzesti 1 Skopje |Varna |Tarnow I Dj erj insk IRimnicu Vilcea |Volgograd |Zadar |Neratovice IKalush Area |Pancevo |Rimnicu Vilcea 1 ASL CASE 1 NUMBER 1 1 101,02,03,04 101,02 1 1 1 1 1 1 1 I 1 1 1 1 1 1 1 1 1 1 1 1 YEAR of ] Is t Exposure 1 1 153,50 > 5A,58 157,50 1 1 i 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 WPX/ASL2 - LANGIOCASES,28 GENC 0081 S3 Page 54 (Review date 1 January 1989 TABLE 12 JAPANESE PVC PRODUCERS - START--UP DATES vs ASL CASES START-UP 1 COMPANY NAME YEAR 1950 | Chisso Corp | Kanegafuchi Rag | Tekkosha 1951 | Mitsui Toatsu 1952 | Mitsubishi Mon | Sumitomo Kag 1951 | Denki Kagaku | Nippon Zeon | Toa Gosei 1955 1 Ryo-Nichi 1956 | Nippon Zeon | Nisshin Kagaku 1957 | Kureha Kasei | Shinetsu Kag 1960 1 Denki Kagaku | Kanegafuchi Kag 1964 | Chisso Corp 1966 | Tokuyama Seksui 1967 | San Arrow Kagak 1 Sumitomo Kag 1968 | Ryo-Nichi | Shinetsu Kag 1970 | Chisso Corp | Denki Kagaku | Kanegafuchi Kag | Kawasaki Yuki I Mitsui Toatsu | Nissan Kagaku | Shinetsu Kag 1971 1 Tekkosha 1973 | Asahi Glass 1974 I Toyo Soda 1975 1977 | Central Kagaku | Toyo Soda | Unknown 1 LOCATION 1 | Minamata | Osaka | Sakata I Nagoya | Yokkaichi | Kikumoto 1 Shibukawa | Kambara | Tckushima 1 Uozu | Takoaka | Takeo | Nishiki | Naoetsu | Ohmi | Takasago | Chiba | Tokuyama | Tokuyama 1 Chiba | Mizushima | Tokuyama | Mizushima | Goi (Chiba) | Kashima | Kawasaki | Sakai 1 Chiba | Kashima | Yokkaichi | Hayatsuki | Sakata 1 Yokkaishi | Kawasaki | Yokkaichi I Kashima 1 ASL CASE 1 NUMBER 1 1 02 1 1 01, 03 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 \ 1 1 1 1 YEAR OF 1 1st EXPOSURE 1 1 58 1 1 53, 65 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 I 1 1 1 1 1 1 WPX/ASL2 - LANGIOCASES,29 GENC (Review dace 1 January 1989) TABLE 13 SOUTH AND CENTRAL AMERICAN PVC PRODUCERS START-UP 1 YEAR | 1953 | 1954 1 1955 | 1956 | 1960 | 1 1961 1965 1966 1967 | | | | 1 1968 | 1970 1 1 1971 1975 1976 1977 | | | | 1978 | 1 1 1979 | COMPANY NAME Monsanto Mexica Policyd Geon Do Brazil Elchlor/Solvay Eleccrochlor Viplastic Indupa PET Columbiana Carburo De Col Plasticos Omega SOC Paramonga Primex Policasa Petro Dow Polimeros Mex Rico Chemicals Petroplas Indust Resistoc Huls Brasil Polychem Policyd PET Camacari ! LOCATION | 1 | Lecheria (Mexico) 1 | | Mexico City (Mexico) | | Sao Paulo (Brazil) | | Sao Caetano (Brazil) | ICapitan Bermudez(Argentina) | | Mendoz (Argentina) | | Cinco Saltos (Argentina) | | Cartagena (Colombia) | | Medellin (Colombia) | | Mexico | I Paramonga (Peru) | | Puebla (Mexico) | I Managua (Nicaragua) | | Conception (Chile) | | St Martin Puebla (Mexico) | 1 Guyanilla (Puerto Rico) | | EL Tablazo (Venezuela) | | Tlazcala (Mexico) | | Cubato (Brazil) I | El Salvador I I Coatzacoalcos (Mexico) I 1 Camacari Bahia (Brazil) | ASL CASE NUMBER | YEAR OF I 1st EXPOSURE 1 1 1 1 1 I 1 1 1 1 1 I 1 1 1 1 1 I 1 1 1 1 WPX/ASL2 - LANGIOCASES,30 Pago 56 (Review date 1 January 1989) TABLE 14 AUSTRALASIAN PVC PRODUCERS START-UP DATES START-UP YEAR Mid 1950s I COMPANY NAME 1 1 | 1CI Australia 1960s | i Late 1970s 1 1 1 B F Goodrich ICI Australia | LOCATION 1 11 1 .1 I Botany, Sydney 1 11 | Melbourne 1 i | Laverton | Melbourne 1 1 1 11 ASL CASE NUMBER 1 YEAR OF 1 1st EXPOSURE 1 1 1 1 1 1 1 1 WPX/ASL2 - LANGIOCASES,31 60C Page 57 (Review date 1 January 1989) TABLE 15 MIDDLE EASTERN PVC PRODUCERS START-UP DATES I START-UP 1 COUNTRY NAME 1 DATE 1 Sept 1986 I Saudi Arabia 11 11 11 1 COMPANY NAME 1 1 1 LOCATION | National Plastic | Company I (Ibn Hayan) ! |Arabian Petrochemical |Madiant lAl-Jubail lAl-Sinahyah Companv WPX/ASL2 - LANGIOCASES,32 gehc 008