Document EmmKvd5djEb7YX8Y5nV84Ogyb

FILE NAME: Hercules Chemical (HERC) DATE: 1960 DOC#: HERC039 DOCUMENT DESCRIPTION: Proceedings of 13th International Congress Occupational Health - Funders, Attendees & Presentations I Proceedings THIRTEENTH INTERNATIONAL C O N G R E S S ON OCCUPATIONAL HEALTH The following corporations, governmental agencies, labor unions, professional societies, and individuals contributed to the financial support of the Congress: AFL/CIO The Alcoa Foundation AMF Foundation Addressograph-Multigraph Corporation Allegheny Ludlum Steel Corporation AAmllise-rCichaalFmoerersLMoyaanltuyfaGctruoruipng Company American Brake Shoe Company American Can Company AAmmeerriiccaann CCaysatnIarmonidPCipome pCaonmypany Am(NeroirctahnerInndCuasltirfoiarlniHa ySgeicetnioen)Association AAmmeerriiccaann MMeetdailcaCl lAimssaoxciFatoiuonndation, Inc. AAmmeerriiccaann MPruestiudaelnItnLsuinreasncLetdA.lliance American Telephone and Telegraph Company American Viscose Corporation Armco Steel Corporation AArtlmanotuirc aRnedfinCionmg pCaonmy pany J. T. Baker Chemical Company Bausch and Lomb Optical Company Baxter Laboratories, Inc. Bayuk Cigars, Inc. BBeotehinlegheAmirpSltaeneel CCoommppaannyy BBruidstdol-CMomyeprsanCyompany Burlington Industries, Inc. Burroughs Wellcome and Company California Texas Oil Corporation Campbell Soup Company The Carrier Foundation, Inc. CCaartesorpn,illPairriTe,raScctootrt aCnodmCpaonmypany CCehlaamnepsieonCoPrappoerratainodn FofibAremeCroicmapany Chance Vought Aircraft, Inc. TChhaeseChMemanshtraatntadnCBoarnpkoration Chesapeake Corporation of Virginia CChitrieyssleSrerCviocrepoCroamtiopnany Clevite Corporation Colgate-Palmolive Company Columbian Carbon Company Consolidated Edison Company of New York, Inc. Continental Can Company, Inc. CCoornntinPernotdaulcOtsilRCefoinmipnagnCy ompany CCroorunsine-gHGinldasssCWomorpkasny Crown Zellerbach Foundation CCuurmtims iPnus bElinshgiinneg CCoommppaannyy DDeeetrroeitanEddiCsoonmpCaonmypany Dodge Manufacturing Corporation DDoowuglCasheAmiriccraal ftCComompapnayny E. I. Dupont de Nemours and Company Dupont, Mr. Irenee EEaassttmOahnioKGodaaskCComompapnayny Electric Storage Battery Company Endicott Johnson Corporation Equitable Life Assurance Society of U.S. Esso Standard Esso Research and Engineering Ethyl Corporation FFaawirccehtitl-dDeCaarminegraPrainndtinIgnsCtroummpeanntyCompany FFeeddeerraall-MPaopgeurl-BBooawredr CBoemarpinagnsy,, IInncc.. Federated Department Stores, Inc. FFoiroedsto&nDe rTuigreRaensedarRcuhbLbearboCroamtopriaens,y Inc. Ford Motor Company TGheneerGaalrrAemt CeroircpaonraTtiroannsportation Company GGeenneerraall ADnynilainmeicasnCdoFriplmoraCtioornporation GGeenneerraall EFoleocdtsricCoCropmorpaatnioyn GGeenneerraall MMioltlos,rsInCco. rporation GGelonbeer-aUl nTiiorne, aInndcoRrpuobrbaetredCompany Goldman, Sachs and Company The B. F. Goodrich Company TGhuelf GOoilodCyoeraproTrairtieonand Rubber Company Gulf Research and Development Company Harnischfeger Corporation Hazleton Laboratories, Inc. Helm, Mr. Harold D. H. Hercules Powder Company, Inc. HHeinyed,enC.NHe.w, pMor.Dt .Chemical Corporation Hinman, Mr. John H. The Hoover Company HHoofpfme aNna-tLuaraRl oGcahse,CoInmcpoarpnoyrated GHeuog.hAes. AHiorrcmraeflt aCnodmCpaonmypany Humble Oil and Refining Company IInnldaunsdtriSatleeMl eCdoicmapl aAnsysociation IInntteerrnnaattiioonnaall BHuasrivneesstserMCacohminpeasnyCorporation IntCeorrnpaotiroantiaolnMinerals and Chemicals IInntteerrnnaattiioonnaall TReelseipsthaonncee CanodmpTaenleygraph Corporation Iranian Oil Consortium Johns-Manville Corporation Johnson and Johnson S. C. Johnson & Son, Inc. Jones & Laughlin Steel Corporation KKaeinsnerecIontdt uCsotrpipeserCCoroprpooraratitoionn KKoimppbeerrslyC-ColmarpkanCyo,rIpnocroartpioonrated LaSalle Steel Company Legge, R. T., M.D. LLeevTeoruBrnroeas.u-CWomesptianngyhouse Company LLiibfeerEtyxteMnusitounalEIxnasmurinaenrcse Company TElhioLmilalsy Ja.nLdipCtoomn,pIanncyorporated The Magnavox Company The Mead Corporation MMeeidgisc,aJl .SWoc.i,etMy .oDf. the State of New York Metropolitan Life Insurance Company MMiinlees SLaafbetoyraAtoprpielisa,nIcnecs. Company Monsanto Chemical Company National Biscuit Company National Dairy Products Corporation National Institutes of Health, Public Health Service, Department of Health, Education and Welfare NNaewtionOarlleLaneasdPuCbolmicpaSneryvice, Inc. Newport News Shipbuilding fc Drydock Co. NNeeww YYoorrkk LSitfaeteInNsuartuanracle GCaosmCpaonrpyoration TNhewe NYeowrkYSotarkteTSiomcieesty of Industrial Medicine TNhorethNeAwms,erNiceawn AYovriaktion, Inc. Norton Company OOhliino MOialthCieosmonpanCyhemical Corporation OOwtisenEs-lCevoartnoirngCompany Owens-Illinois Glass Company Pan-American World Airways, Inc. Paramount Pictures Corporation Pennsylvania Railroad The Peoples Natural Gas Company Pepsi-Cola Company Pittsburgh Steel Company PPrroocvtiedrenatndLifGeaSmc AblceciCdeonmtpIannsyurance Co. RRaaydtihoeoCnorCpoomraptiaonny of America RReevpluobnlicFoSutenedl aCtioornp, oIrnactioornporated RR.eyJn. oRldesynMoledtsalTsoCboamccpoanCyompany Richfield Oil Corporation John A. Roeblings & Sons Corporation Joseph E. Seagram 8c Sons, Inc. SSihmelplleOxilWCiroemapnadnyCable Company ASi.nOcla. iSrmRitehfinCinorgpCoroamtipoanny SSoocnooncyo MProobdiulcOtsiCl oCmompapnayny SSptaenrrdyarGdyOroislcCopoempCaonmypa(Cnyalifornia) Standard Oil Company (Indiana) i - i i a -i v y i' A J w iN is K a iUUO Standard Oil Company (New Jersey) and affiliates Standard Oil Company (Ohio) Standard Railway Equipment Company Foundation Standard-Vacuum Oil Company Stauffer Corporation Studebaker Packard Corporation SSuungaOr iBleCetomPrpoadnuycts Company SSuwnifsttraanndd CCoomrppoarnaytion Sylvania Electric Products, Inc. Tampax, Incorporated Tennessee Corporation Texas Company TTiedxeaws aItnesrtrOumil eCnotsm, pInacn.y TTrhaensMWichoareldl TAoirdwdayEsstate The Travelers Union Carbide Corporation Union Oil Company of California United Artists Corporation United States Atomic Energy Commission United States Rubber Company United States Steel Corporation United Steel Workers of America UUnpijvoehrnsaCl oOmilpaPnryoducts Company VAW--International Executive Board Washington Steel Corporation Weirton Steel Company Western Electric Company, Inc. Westinghouse Electric Corporation WWiillssoonn, &MTr.ooCmhaerrleFseErt.ilizer Company Wiremold Company WWmoo.dWarrdigRleeys,eaJrrc. hCoCmorppaonryation Union Bag-Camp Paper Company Zenith Radio Corporation THIRTEENTH C O N G R E S S ON July 25-29, i960 Copyright 1961 by the U. S. Executive Committee of the Thirteenth International Congress on Occupational Health ALL RIGHTS RESERVED Library of Congress Catalog Caid Numbei: 58-32683 I Public Health GIFT DESIGNED BY HARVEY SATENSTEIN MANUFACTURED IN THE UNITED STATES OF AMERICA BY BOOK CRAFTSMEN ASSOCIATES, INC., NEW YORK RC ^^3 A I Z< o5T /<? 3 V 3irulebcv! /iHr ts Lb ra.ry EXECUTIVE COMMITTEE Chairman Vice-Chairmen . L. W ade, M.D. L. G reenburg, M.D. Secretary-General Treasurer Executive Secretary S. E. M iller , M.D. R. E. E ckardt, M.D. H. E. T ebrock, M.D. J. W . M uckell E. R . A ston, D.D.S. C. U. D e r n eh l , M.D. T. E ly, M.D. B. S. Fox J. L auer, M.D. H. L. M agnuson, M.D. H. B. N a c h tig a ll, M.D. N . N elson, P h .D. M. N . N ew quist, M.D. L. T. R obertson, M.D. I. R. T abersh aw , M.D. S. P. W agner, R.N. 940 10 REPORTS OF ORGANIZING COMMITTEES In addition, many others visited points of interest to them either before or after the Congress. When the debris had been cleared away and the hubbub had subsided by Saturday, July 30, the paid registrations figures for the Congress were as shown in the following tabulation. NUMBER OF REGISTRANTS -- BY COUNTRIES Country Afghanistan .. Algeria .......... Argentina ... Australia . . . . Austria .......... Bahrein ........ Belgium ........ Bolivia .......... Brazil ............ British Guiana Canada .......... C h ile.............. Colombia .... Cuba .............. Czechoslovakia Denmark .... Finland ........ France .......... Germany . . . . Greece .......... In d ia .............. Indonesia . ... Iran .............. Ireland .......... Israel ............ Italy .............. Total Country in Total m th 1 Japan ................................................... 20 th th 1 Luxembourg ...................................... 3 19 3 Mexico ................................................ 6 Morocco .............................................. 1 pi 8 Netherlands ........................................ 16 lit ci 1 Netherlands-Antilles ........................ 2 Northern Rhodesia .......................... 1 to 2 1 Norway ............................................... 13 5 Pakistan ............................................... 1 at P1 2 54 Peru ..................................................... 4 Philippines ........................................ 5 ac w 4 9 5 Portugal ............................................... 5 Romania ............................................ 1 I p Spain ................................................... 5 I oi 1 4 Sweden ................................................ 29 Switzerland ........................................ 6 ol sc w 62 39 Thailand ............................................ 1 Trinidad ............................................ 2 b d 36 1 Union of South Africa .................... 9 United Kingdom .............................. 94 ic 5 1 United States ..................................... 1040 Uruguay ............................................ 2 tl 2 U.S.S.R................................................... 1 b 1 Venezuela ........................................... 7 Yugoslavia .......................................... 4 a ii 2 21 Total ............................................1568 tl b o One hundred and ten people paid and registered but were unable, for one reason or another, to attend. Thus the total actually present, exclusive of wives or guests, was 1458. It is the impression of the Organizing Committee that the Congress was an overwhelming success. Certainly the number and quality of the scientific papers delivered was outstanding. Dr. Irving Tabershaw and his whole Program Committee deserve a special note of thanks for iV the hard work entailed in bringing such an excellent program to the Congress. It is the hope of the Organizing Committee that all those who attended, especially those from foreign lands, not only learned much from their attendance at the Congress but found our land and our I people friendly and hospitable. W e hope that new friendships were made, new understand ings reached, and that the memories of the Thirteenth International Congress on Occupa 7 tional Health will linger long. Speaking for all members of the Organizing Committee, it was a pleasure and privilege for us to plan the Congress and welcome all who attended. J KIVILUOTO 311 amsl ionf Athpepbeunfdfiexr d1e.scNriobremdailnlyAfpoprebnldoioxd1,spaencdimceonnstinthuee foifnatlhrwicaeshasinfgormuursint ebespepceirmfoernms.ed four times, instead APPENDIX 3-- COPROPORPHYRIN ESTIMATION tubTeo a5ddm0l.2frmeslhly3 pveoridecdenturhinyedroingena psteorpopxeidreedsotelust gtieonnt,ly,1 rmelleagsleacpiraelssaucreet,icanadcidplaacned in3 amlligehthtperro.oSfhbaokxe voivoelrentiglhigt.htO, basnedrvegrtahdee rethde flsupoerceismceennce0-u-|n--d(--er|--upltrbay degree of fluorescence. APPENDIX 4-- HEMOGLOBIN DETERMINATION wiTthake0 40.0p5emr lcbelnotoda,mamndonmiuamke huypdrtoox9idem. isMveoalusumree a(EbEsoLrp4ti0o4n), oannda ccoonlovreirmt etthere, ruesaidnignga tsotanhdeamrodglfoilbtienr ppaerrceedntcaagleibrtaotiotnhegrnaepahr.est even number from a pre APPENDIX 5-- PUNCTATE BASOPHIL COUNTS thiMckankeess,a ftixhinforblaoboodutsmoneaermoinnuatesliindemoefth0yl8-1al0comhoml, a(1llogwmteothdyrlyeneanbdluset,ai6ngfsoord3iu0msebciocnadrsboinnatSeelilnars10s0taminl daesieoanigzeredenwactoelro)r.. Wash in tap water until the slide is eyeUpsiiencge saet dtoarak 6-gmromunsdquacroen,dceonusnert tahned(puannctaEtehrcliecllhs ipnuntcetnatecocnesllescaurteiveclafsiseilfdise.d (aAs llathrgoeu,gmh eidniucmo,usnmtianlgl,, vtehrye cfienlelu, loarr psotrlyucchturorem,e,thaicscodridfifnegrentotiathtieonsizies offotrhefuirntthrear rtoeftearlenccoeunotn iasngiinvdeinv.)iduCalolsceasteh,eanedyenpoiercmealtloy oanl2y-mthme sbqoutharec,ouanntds fcioveunttimthese oRn.Bd.Cif.feirnentthpisartssquoafret.heRespliedaet, Rto.Bg.Civ.e caoupnut nocftatfeivecosumnatllofon5e0s. laCrgaelcufliaetledspaunndctaatne per 1000 R.B.C. NONOCCUPATIONAL ASBESTOSIS R aimo Kiyiluoto Roentgen Department of the Central Hospital of Northern Karelia Introduction InPtlheueraaldvraenaccteidoncaissesveoryf tohfitsenpnoebusmervoecdoniinosiassbpelsetousriasl. fciobrrroesliastiohnas bbeteweneenalmploesutraallwcahyasngfeosunadn,d atnhde saevcelreitayr oinfvtehsetigpautolmrso. nOabrysefrivbartoiosinsshoans tbheeenococbusrerrevnecde boyf psleevuerraall ocaflcpifliecuartiaoln cianlcaisfbiceasttioosnis hasavea arlosoenbtgeeennomloagdice. Rsigenporotsr cboymtphleicaGtieornmaonf aasubthesotrossis(1)h.avIne aesdpdeictiioalnly tobeaednvamnacedde wcahseicshofplaesubreasltosciasl,csifpieccaitaiolncahsaess hbaeveen bteheen cphrieesfenfitneddining (b2e)e.nEoxbcseeprtveidn aamsboensgtoswiso,rkpelresureaxlpocsaeldciftiocattaiolcnahnadsmailcsoa a(Ss,b4e)stoosr (t5o).various dusts including a short exposure to onThocecudpiaagtinoonsaisl oexf pponseuurme otcoondiuossti.s Oisnlpyrimvearryilyfewbasreed pmoaryts boef pfnoeuunmdoicnontihoseeslitweirtahtouuret o(c6c,u7p,8a)t.ioInnal Nexoprtohseurrne Kbeaerneliaat,traFcitneldanbdy, tdhuerhiniggh fienwcidpeanscte yoefacrsaseisntoefrepslteuhraasl croaelcnitfgiceantoiolongsihcowpiicntgurae,ravthereyr csiumriiolaurs atondthchataraocbtseerrivsteidc ainmponnegumthoecorneisoisdeesn.tsThoef caasceesrhtaaivne abreeean, manadinliyn fothuensde cpalseeusranlodipsreeavseioucsouhldistobery eloifcitaedde.qTuahtee opcuclumpoantiaornys oorf tohfe tphaetiepnattsiesnhtsowheaddnonouncilfionrimcailty,syamndptothmes moafinpnpeaurt mreovceoanleidositsh.atAthsetuydwy eoref gthroeupareedalroduinstdribtwuotioannthoofpchaysel-s leixtet-earsnbaelstofsactmorinesso.uAghstb.estEovsenconfrsotimtutead stohleelycomromenotn- gbeenenolocgoincsipdoeriendt othfevmiewos,t apsrboebstaobsleduestitolionghya.lation had tubPelrecuurlaolsisc,alocrifiecmatipoynemraesuusltuianlgly forcocmurshuenmiloattheorarallxy, manadrkiesd siptuleauteradl otnhictkheenivnisgcearanld pdleisuprala.ceInmemntosot fcatshees sinutlrtainthgofrraocmic dourgstanisnhiaslaotbiosenrvuesdu.aTllyheocccaulrcsifibcialtaitoenralrley aadnvdaniscemd osctasoefstencalsciituumateddeopnositthse apraerieftoaulnpdleuinra.thIne Tlahteeraclalpcaiurtms odfeptohseitschteaskte, bvaasraiolluys afnodrmms--edlaiarsgteinaclolyn. fluent plaques, bizarre figures, or roundish spots. The Roentgenologic and Clinical Picture of Cases Observed in Northern Karelia bilIantertahlely aidnvatnhceedcecnatsreasl pcaalrctisumof dtheepodsiitaspharraegmfo;unodn achnedstown atlhlse, mesepdeciaiasltliynaalnstuerrfoalcaetse.raIlnlythbeutinaclsipoiednotrscaalslyes, ltahteercaallccihuemst dwepalols,itmtoarkeesofptleanceoeniththeer loenft,thoer ainntetrhoe ocenntrthale parirgtshto. f Ptheericdairadpiharlagcmal,ciafpicpaatiroenntlyis msoomreetoifmteens preTsheent.calcium deposits are located on the parietal pdleepuorsai.tsIwn eare soebriseesrvoefd.15T0hecapseasrientoalinlotecraltoiobnarhcaaslcbieuemn dtieomnso,nasntrdatietdhabsyalsdoiabgeneonstnicotepdneinumsoomtheoraauxtopesxieadmiannad spuarrgieictaall lcoacseast.ioUn soinfgsoalittaarnygepnltaiqaul ersoemnatgyenbeboeabmse,rvtehde, tchheesset wpalallqourestohwaavridngthethdeiiarphbraasgems .toInwaarddvanthceed icnanseers the lack of soft tissue mass between the calcium deposit 312 MEDICAL PRACTICES aanpdpariennnte,ranchdesdtiawgnaollstidcuael ptoneuthmeotphaorrieatxalexloamcaitnioantioins pasublemstoonsarmyinfeisb.rosis among residents around the two is Tsehldeommanjoereidtyed.of cases of pleural calcification de attSriobmuetiningvetshtiegactoalrcsifhicaavteionpoitnoteidnhoaulattitohne ddiaffmicaugltey ionf sscerriiebsedofa1b5o0vecasheasvtehebeoerdnincalrinyiccahlelyst sroymenpttgoemnleesxsa. mIninaa ovbieswervoefditsinpatrhieetalul nlgocaotrionth,efevwi,sciefraalnyp,lechuarange(2s,5b)e.inIgt ftiiobrnosbisy, Pc-oArraenspdonladtienrgal tporotjheectiaonntseprreivmeaalreyd oprulpmriomnaarryy slueenmgs apnodssivbilsecetrhalatptlheueraasbinestoreslaftiiboenrs tmo otvhee wpiathrietthael scteangte. Eovfenputlhmeonmaaryin apsabretstoosfisthienseocnalsyesabhoadut n1o4 spuebr ponlelyu,ra,asthpursevicoauussliyngprceaspeinlltaerdy bhyemtohrerhaaguetshoor.n Tthhies jective respiratory symptoms. The series mentioned above has been selected solely hlaegmenoorruhsagpelacqouaeguwlahteicshansldowolrygacnailzceisfi,esf.orTmhinisg tahecooryl atoccootrhdeinr gfatcotortsh.eTrhoeenctognencendtiraagtnioonsisofwtihtehocuatsesreaferroeunncde cinohualdlateixopnlaoifn stmheallcoquurasentiotfietsheofprfoibcreosussremsuinlteirnagl fdruosmt. tcwomo masubneesstohsasmainseysetinbeKenuuthsjerovnilyanwdayittso nceoingfhirbmoritnhge seeTmhse toclinbiecaslligsihgtn,iftihceancmeaojofritthye opflecuasreasl schaolcwifiincgationno roouetsnitdgeenthidsiaagrneoasihsa. dTphreevimouasjloyritlyiveodf th2e5rec.aAsecscolrivdiinngg colninitchaisl proesinptiraatroeryneesdyemdp. toms. Further investigations ftoicutlhtestoe fcarcetdsi,t anIny ovethryerfeewtiocloagseys wa opurledviboeusveorcycudpiaf pleFuroraml craolceinfitcgaetnioonlogisicofpsooimnte soifgnvifiiecwan, cet.hiTs heenrdoeemnitc wtiohnicahl leexnpdossusrleightto suaspbpeostrotstodutshte hraosenbtgeeenn doibasgenrovseids., dgiefnficduilatg. nEosairslyis pinleutyraplicaclhacnasgeesseaosny bthuet inansteormoelactearsaesl Tmheethoddiasg. nIonsitshehasspuastuymet onfo2t0bceaesnesconnofiarsmbeedstobsybootdhieesr cphlaeqstuews'alml amyaycasuimseuldaitfeficiunlftiyltriantioinnste, rapnrdetalatirogne coaflcipfiueld wameroeunftouonfd,anatnhdophasyblleistteosasfbibesetrosinwaosnefoucnasde. inSmthalel mvooltnaagrey cthecanhgneiqsubey chaidninhgeirnefbiyltrabtieoness.pTechiaellhyighreckoilmo- lfuronmg othfeavnicainuittoyposifedthecaassebeasntods imninteh.e lung of a cow masebnesdteods. mIninecsheisnt Nrooernthtgeernn eKxaarmeliinaaatinodnsofofOwutoorkkuemrspouf Discussion Cbeopppaeridmitnoesthloecatfeadct inthtahte seavmene aerexatenastitvenetiobnilamteurastl pleural calcification does not have to be a sign of va1 aroTuhned ttohteal twnuomabsebrestoofs cmasiensesofampoleuunrtasl tocalocvifeicra8ti0o0n, sdeuvsetreexppuolsmuroen.ary changes resulting from occupational <4$ acsaspesrewvaiosufsolyunrdepionrtaedmabsys tshuerveayutohfora.bTouhtis10n,u00m0baedruoltf REFERENCES ipnahtiaobniatalnetsxpaonsdurme atyo inascbluesdteoscadsuesst.wiItnh pthreevihoiustsoroyccouf the main part of cases examined at the Central Hos 1. JKaocmobp,liGka.,tioanndenBodhelrig,LHu.n:geDniaesbresnttogseen.oloFgoirstcschhern. Rntgenstr., 83:515, 1955. ppoitsaulreof hNaos,rthheorwnevKearr,elbiaeetnhe alpacpkaroefnto. ccSuopmaetionoafl tehxe patients have not had any idea how the dust inhalation 2. DMiuelleSrt,auHb.l:unUgbeenrerskcrhawnekruengFeonr,meBnandder3,AsWbeisstsoesne. schaft!. Forschungsberichte 66. Dietrich Steinkopfl cthoautldthheavdeustharpispinegneodn; tthhee rsoaamdes mcaisgehst hbaeveresppreosnusmibeled 3. VSieerglaalg,,WD.a;rSmmstiathd,t,A1.9R58.;. and Greenburg, L.: Study of talc miners and millers. Indust. Bull., 22:434, pInavNemoretnhte.rnWKitharoeulita mthinerroalaodgsie(heigxhawmaiynsa)tiodnosniott ihs,avoef 4. S19m43it.h, A. R.: Pleural calcification resulting from caoreurrsee,suimltipnogssfirbolme toindheaclaidtieown hoefthaenrthtohepsheylclaitlec-iafiscbaetisotonss e6x7:p3o7s5u,re195t2o. certain dusts. Am. J. Roentgenol, dfaucset doerpigoisnitastinogf oftrhoemr ftihberoaussbedsutossts,msiuncehs oasr tfrreommolsiuter- 5. iFnefhorlge,e Wb.e:rufbliecrhedropSptealusebietiignewiPrkleuunrgavener.kaFlkorutnscghern. aKsabreesltioas., Twhheichfirisst aalvteerrynactoivmemsoenemms intoerable inmoNreorpthreorbn 6. ERisnetngbeunds,tr.M, 8.;3:W16a, n1t9a5,6.R. C.; Dustan, C.; Stead abIlen. occupational pneumoconiosis some authors have omcacnu,paLt.ioTn.a;l Hbaerrriysl,lioWsi.s.B.;Aamn.d JW. olIfn, dBu.stS..: HNyogn.-, 77:282, 1949. cbaelslieddesatthteentpiroonmitonenthteapapbeseanracneceofopf uthlmeopnlaeruyraflibcraolsciis 7. pGoopyuall,atRio.nK.:ofPnReuamjaoscthoannio.siJs.inInthdieannonM-iendd.usAtrsisa.l, fhiacsatiboenen(2o,5b)s;ervoend thbeetwoethener thheansde,vearitcyleaorf pcourlmreolantaioryn 8. 3K0i:v7i9lu, o1t9o5,8.R.: Pleural calcification as a roent faisbbreosstiossiasnidt pisleauprpaal rceanlct iftihcaattioexnte(9n)s.ivIen cnaclnciofciccautpioantiomnaayl gpehnyolllioteg-iacsbsiegsntosoifs.noAnc-toaccruapdiaotilo.,nasul pepnld.em19i4c, a1n9t6h0o.- mococnuarrywiftihbrooustis.anItysereomenstgpeonsosilbolgeictahllayt edveetnecvtaebryle smpualll 9. Btoosehlidge,rHL.u; nJgaecno.b,GGe.o;rganTdhiMemuleleVr,eHrla.:g,DSietuAttsgbaerst, atimonosu.nts of asbestos fibers may cause pleural calcifica 10. V19o6r0w. ald, A. J.; Durkan, T. M.; and Pratt, P. C,: Experimental studies of asbestosis. Arch. Indust. InAanntihmoaplhytellsittse bisritmtleoremsintieffratlhafinbesresrpheanvteinneotascbaeustsoesd. pulmonary fibrosis (10), but fibrosis has been observed 11. HNyogro.,, 3:L1.,: 19O5n1. the histology of asbestosis. Acta Pathol, et microbiol. Scand., 23:53, 1946. i1n2).woFrukretrhserexpstousdeidestoaraenthnoepedheydlliteto-asrbeevsetaols dthuest p(a1r1t, 12. Wasbeegsetloisuiss, oCb.s:eCrvheadnginesFiinnlathned.luAncgtas irnad1to26l.,c2a8se:1s3o9f, & possibly played by asbestos as an tiologie factor in 1947. ?. 326 MEDICAL PRACTICES A REVIEW OF RECENT DEVELOPMENTS IN OCCUPATIONAL PULMONARY DISEASES OTHER THAN SILICOSIS L e o N o r o , M.D. Finland tioAntalthHeeaTlwthelfhtehldInitnernHaetlisoinnakli Cthornegeresyseaorsn aOgoc,cutphae is Oaulrreakdnyowflaeidrglye ocfommapnleytef:actIorsaminfltuheinnckiinngg thoenllyungosf Fsurbenjeccht mPreonfteisosnoerdMinarcthheantditlep,reaselanrtgeed aandrevcioemwporefhethne iansjbuersiteoss,is;sutchhoseasmcahnlyor choerminciatlrsoucsaufsuinmges;acuatned lutnhge sTivhee bOibrgliaongizrainpghyCobmeimngittaetetahcahsedat tothihsistimpreesaesnkteadtiomne. odiusreaksnesowclaeudsgeed isbystibllacvteerryia,ressptroincgteeds,, aonrdvitrhueseisnteOrpftreen stoevperraelseynetaras. rIetvimewustofatthoencseambee ssauibdjetchtaftrothme tchoemlpaislt ttahtiisoniss tirnuemoafnyallienrdgiivcidduisaelasceasseasnadrechdrioffnicicultbrtooncmhaikties,, ienagsy otfassku.chMoarebitbhlaiongreavpehricberfeovriee,wrehsaesarcnhot wboerekn haans alunndg escpaencciearl,lyemofphthyesermoale, oafndnonfipbrroosfeisssioonnatlhaendwhporloe, pbreoebnlefmocuhseads obneeonccduispcautsiosendal aptulnmatoionanrayl dainsdeasienst.eTrnhae hfeasvseio, nwalithensvpiercoinaml eanptpsreicniatitohneirtooGccruerartenBceri.taYine'st ewxe taigoonailn mMeeiltainng. sF, rtohme ltahset ltiimtereatbueriengwohniclhy htwaso bmeoennthast pceolslaelnt ovfitatlhestarteislatitciso,nsimhipporbtaentwt eeevnideonccceupaattioonur adnisd mreycednitspyoesaarsl, dIeahlaivneg fwoiutnhdthailsmsousbtje3c1t6, aanrtdiclyeest fIrocmannthoet ceArtaftienr puthlims ongaernyeradlisesauservs,eys,ucnhowas clhertonuisc bstruodnychittihse. hliasvheedhaind athcceesws otrolda.llI thshealalrtficolleloswf,rowmiththissomfieeldexpcuebp dcoetnanielsc.tioSnin, cIeshsaillilcobseigsinwwilrlithbeasbdeisstcoussiss.ed in another tioTnsh,erMe airschreaansdo'sn ctloasssitfaitceatiaotn.the onset that the con Asbestosis sbteacnotmiendmusotrriealiaznindg misorceauspionlgluttehde. aiGrrewaet bmreaasstehse otof asbTehsteosmisajiosrcpoanrttaionfedourinprtehseenetxkcneollwenletdGgeercmonancerbnoinokg cpoeuonptlrei,ese,veanrethechpaenogpilnegs otfhethire bsorecaatlhleindglesasi-rdetvherlooupgehd LthuantgeanppbeyareBdohsloigm-eJacmobo-nMthuslleargo,ThDisie bAosobkesctoosnetaidnesr, tIhaemir mheorveemtheinntkifnrogmspaegcriifcicualltluyraalbotoutintdhuesthriuagleceinndteurss. ipnracatdicdaitlliyon thtoe 7e0n0tiroef wthoerilrd olwitneractausrees, irnefetrheinscesfietlod atrniadlizCahtiinoan. Bpruotcemssanr'isgbhrteantohwingtaokrginagns,plaancde eisnpeIcniadlilya a(sboomuet 6th5e0 preaftehroegnecnese)s.isT, hcelirneic,ispnroogthnionsgis,baasnidcalplyrevneenw hfliusenlucnesgso, ndlyo innotthceomweoirnkincgonetancvtirownimthenhta.zaTrdhoeusmoinst otibotnainoefdthaibsoduitsetahsee. fFreuqrutehnecryinofforcmlinaitcioaln siysm, phtoowmesvears, --coims mraopnidployllutrtiaunmt pohfionugr ablrleaotvheirngthaeir--wotorbldaccwoitshmothkee wfroelml atshreoaenuttgheonros'locgaircefaunldexbarmoninchatoigornapohnicthoebirsemrvaatteiorinasl rdioscintogrssttaankedatrodwoafrnlimvianngk, inind ospf iittes doafngtheer. Tefhfoertasutwoe olufn7g00cacnacseers.isTshteillresltaattiiostnicsahlilpy binedtweteeernmiansebdes.toIsnisspanitde mpoolbluiltee itnhdeusatirry oifs pthreodturacfifnicg rcoaardssi.nWaitrhaptihdetegmropwointgo othfetihrios,wn"assbpeesctiofiscactaionncetro" iet.xists, and the authors give ppoowpuelratiaonnd chenetaetrisn,g,anmd otrheeirpoinllcurteaanstesd eunseteor f tfhueel afiorr. affDecotesas,asfboerstoexsamdupslet, hbaevryellisuimm?ilaTrhinsonisocacuppraotibolenmal 11 ? hBaavceternioast,dvisiraupspeesa, rsepdonegitehse,r.anTdhuost,htehresemnavlilroonrgmaennistmosf nthoantochcauspbaetieonnaelxpopsleedurathlrocuaglchiftihcaetioobnsercvasaetison(sso-ocfal1le2d6 Wmahni,lewtihthe rgefreeraetnceenetmoylunogfs,thies clhuannggs,ingtubcoernctiunlousoiuss,lyis. lnaetiigohnbolirvhionogdacroasuens)d tthwaot hoapdenbeaesnbefsotousndquinarrtihees,ppoupbu gnerawduiamllpyodrtiasnacpepetaorinthge, naeiwr idmispeausreitsieasr.e Carhirsoinngic, gbivroinng lsitsuhdeyd, tbhye tdheetaFilisnnofiswh hDicrh. Kthievialuuothtoo.rAwcicllorpdriensgenttohtihmis cmhuitcihs, amstohrme ai,mempoprhtyasnetmdai,saeansdeslunthgancantcuebreracrueloaslriesadiny stieolfn actastehsisweCreonfgoruenssd, imnotrhee tmhainnut8e00x-praleyuirnavlesctailgcaiftiicoan cliovuinngtrisetsanwdaitrhd,highly developed industry and a high oanfyfaromcceursp,atwioonraklmeenx,poasnudret.heCiarlcwifiivceast,iownhowansevuesruhalaldy enMviraonnmhiemnstelaflsaondretqhueircehaantgteinngtioonf. hAisllreeragcietisonarteo othnee olocccautpedatiionnaplaraisebteasltopsilse.urIan, amsoistt iisnsatlasnocems oistt oocfcteunrreidn^ pinrgobloermga,nfisomr sextahmropuleg.hTthhee draenspgierratoofryallaenrgdendsigaefsfteicvte absiltaintearlalclyalcoifnicathtieoninwnaesr cahlseost owftaelnl. oBbassearlveadn,d ampeudli moregdaincsineasn,dfotohdes, sckoisnmeisticcso, netticn.,uoaureslycominmcroenasianllge;rgnenews. mcaolcniafircyatfioibnrowsiass bneoitnigcedfotuondapopnelayr oslnowalyf.ewThceasseesr.oTenhte- Abrleleartghiicngreaocrtgioannss aarnedimthpeoirrtaonbtvwiohuesn cwonenceocntisoinderwtihthe giceanlolsoygmicpatlolymsn.otiTcheaebsele ochbasenrgveastigoanvse minsaikgenifiitcanevt icdleinnt dthiseeaasiers iomfptuhreitileusn.gsMoacncyurofontlhye acfhterronaiclooncgcuepxaptoiosunrael ttihoant omfetahseureensvmirounstmbeentstaskuernrotuonpdrienvgenthtethfaectaoirriepsoallnud otifmeth. eWsee dairseeagsersaduaamlloyn,ghotwhoesveer,ococbusperavtiionngalthegrsoiugpnss aasrbeemstoostivqautiaornriefso.r TsihmeilraersiunltvsesotifgaDtiro.nKs iivnilouothtoe'rs cwoournk which have been exposed for some length of time. tries to certify these observations. k NORO 327 cOotnhieorsifsi'b'rcoatiucseludnbgydsisieliacsaetsesa,nmd i"xbedenoigrnnponne-usimlicoa cdaursbtosru(Gndlausms ,wocoelm, esnetr,icFiteu,llesril'slimeaanrtihte,, cthalicn,a aannthdrabcoalll, mclaicyas,, Tghroapmhaiste,(bagsyicp)susmla,g, keatco.l)in, limestone, marble, talIcossihsalalndpasgsratphhisitegrluonugp, wwihthichaarberiesftillmoebnjteioctns ooff cdoonutbitneudolyus, trheesedarucshts. Wofitthhisgrgeraotuepnohuavgeh tehxepior saufrfee,ctuinn wthiethocicmurprreonvceedofhyfigbireonseis. tHheosweevteyrp,eist iosf evpiudlemntontahrayt changes will become more and more rare. Pneumopathies due to toxic chemicals and metals deGsmasoedsu, r,F uhmydersocaanrdbonVsa,pooirlss, (kCelr,osNenOe,a,etSc.0) 2, borans, cadMmetiuamls, c(hArloumm,incioubma,lt,afnlutiomr,ong,oldb,ariiruomn,, mbaenrgyallniuesme,, ntiitcakneilu, mo,smvaiunmad,iupmla,tiwnuolmfr,amse, lezniricuomn,iusmu,lfeutrc,.) tungsten, ingThteheamlouungnst oifs tocxoincticnhueomuisclayls garnodwimnge.talVs ainnaflduieunmc, cehsproecmia,llayndinbeSrwyleldiuemn ahnadve inbeeonursuhbjoescttscoouf nrtersye,artchhe, cUreSa.sAin. gT. hIet iims pnoercteasnscaery,ofhvowaneavdeiru,mtoisbeesapreciinallymiinnd othilatcowmitihngthferoemxpvaanrdioinugs upsaertosf oofil thheeatwinogrl,dthceonctrauidnes vacaincadsiuulmfurincovmerpyoduinfdfesreinnt atmheouansths.esThise arlosloe otof thbee rweomueldmbreerfeedr.yoFuortoathdeetpariolecdeedsitnugdsy ofofthbeercyolnlifuemre,nceI hHeeladltha)t; athecomMp.Ir.eTh.enisnive19l5is8t o(Af Mref.Aer.enAcerscho. nInbdeurystl. ilniugms. WisecionntEaiunreodpei,ntoampyubklnicoawtlieodngeo,ndothnesoet hparovecetehde bthige UproSb.Ale. ms with beryllium which seem to exist in allItthies nimewposcshiebmlei,cailns twhiitsh sihrorirttanptreesfefnectat toionn,thteo lnuanmgse. Wteme pitnindgusttoriaelvaplhuyasteicitahnes ahftaevreeffsepcetscioalf adcifuftiecuiltrireistanatts wtoiththerelfuenregnsce(nittorouetsiofluomgiecs,diCffle,reSnOtiza,l etdci.a)g, neosspteiccsialilny chronic bronchitis and emphysema. pPnneeuummoompaytchoiseessdu(eActtoinoormgyacnoiscis,duasstpse, raglillelorsgies,nscoacncdi ddyioeisd,omfeyactohseirss,,cofrlkou(sr,ubegrroasiins,), cgoutmton a(cbaycsisain, oshisa)i,r,druhgasy, b(foasrims),er'slinleunn,g),mohnisitloiapsliass,monsoics,ardjuiotsei,s, lesapthoerortri(cchaonsnias-, sugar cane (bagassosis),-tobacco (tabaccosis), tropical woTohdse, eatgcr.)icultural population has received increased oafttethnetiorenladtiuorninshgipthbeeltawsetefnewwoyrekarasnidn htehaeltihn.v"eFstaigrmateior'ns ltuunreg"haanvde optrhoevredpulsmuropnriasriyngdlyiseacsoems mfoounndupinonagcrliocsuelr ipnovweestrisgatotioinnsv.eUstnigfaotretutnhaetseelyc,osnodfiatirotnhserien htahveecnooutnbtreieens wwohresrte hythgeienaigcrcicounldtuitriaolnsp. oWpeulahtaivoen nwotoreknsouugnhdkenr owthle ethdegeoladboAustiatnhericpeulmmiollns,arfyordeisxeaamsepsleo.f the workers in unTclheear,effaencdt mweechaarneismalsoof imn oast doirfgfiacnuilct dfiuesldts, iws hsetirlel bacteriology and allergology will be of much help in --sevaecruatle,cassuebsa. cWuthe,atchfaroctnoircs; epfrfoetcetinins,dailfcfaelroeindts,ciornridtiatitoinngs imncelcuhdaendic--afarectoqrsu,esttoioxnics, tahlaletrgairce, sbtailcltewriaa,itinthge tosilibcae wanisthwebreydss.inIonsisaidsdsittiiolln,cofnotrradeixcatomryplei,n tdhieffeerexnptercieonucne otrfieEs.ngTlhanedinmtearkeestionnge rethseinakrchthraetsuthltiss odfisDears.eShcahsillninogt ymeyt odwisnapcpoeuanretrdy.as has been contemporary thought in aInncfheycltoiostuosmaonsids, paanrtahsraitxa,ibpilnheaurzmioosips,atbhriuecsell(oAsmis,ebhiyadsias-, etittco.s)is, leptospirosis, ornithosis, tuberculosis, tularaemia, difWficiuthltietsheindiseetaioselosgoicf tdhiiasgngorostuicps:thwerheenareisctohnetininufoeucs qtiuoensttioonbeiscovnersyideirmedpodrutaentt,o fwoorrkexaanmdplwe,hewnitnhot?tuTbehre caunldospisn.eOumf coocuornsieo,sethseisreulnatdieornschoinpstbaenttwseteundyt.uberculosis cLhuronmg actaesn,ceirsodpuroeptyol ocalccuophaotliomn anu(Afarcsteunri,nga,sbneisctkoesl,, radTiohaectSivecerestuabrystaGnecense,raeltco.)f our Congress, Dr. Eckardt, hreanncdeleosf thcaencroerleinofhwisorbkoionkg Icnodnudsittrioianls Cinarctihneogoecnceusirs smuospstecvteadrietdhlyat ainndinwdiuthstrgyoomdancryitioctihsmer. sYuebtstiatnicsestoalbsoe hfiaevlde, ahocwaenvceerr,ogisensetitlilc veefrfyectl.imOituerd,kannodwleadltgheouignh tehxis pineripmraecntitcael cnaencceessrarryesefaacrctsh. hItasisgohnoepefdar,thwate tshtiellwlaecllkewnidllowmeodrecatnhcaenl obregfoanreizactoionncsernandthermesseealvrcehs winistthitutthees ocTcuhpeatiroensualltsasfpreocmts itnhethienveetsiotilgoagtyioonf bcyancUe.rS.. Publit Hmeinaeltrhs aSreerviecxepeccotnecderwniinthg gthreeaht aiznatredrsesot.f Wradhieatthioenr sthtoe cinasetsheofvSercyhnweiedbeesrpgreaandd uJoraancihuimmstmalinwinilgl gisetasuqcuceesstsioorns that will presently be answered. Pneumopathies caused by radiation alrTeahdeyinbfeluenencreefeorfreradditaotiaobnovaes.thOeucrakunseowoflecdagnecearbohuast sthmeallo.thIenr ceofnfencetsctioofn rawdiitahtiothneraopny,thleargluengdsoseasre(1v00er0y2in000thre.) fhoarmve boefepnnfeouumndontiotiscaaunsed cfhiabnrogseiss.inFrtohme luEnagsst Gmeornmiaancyasethoefrea ccohmemesistt,hwe hriecpholretdotfo adecahthro; ntihce pcnaeuuse odfusdteoatvherbaeinpgercioodnsiodfer2e0dytehaers.breathing of radioactive Conclusion daTtioonouforrprtehseentteckhnnoicwalledpgree,vewnetioalnreaodfythheasvee daisefoasuens Wpreevaernetioasn:yewt einknaowweatokoerlpitotlseitiaobnouast twohtyheoinrempeedriscoanl gmeutschthreemseaarcnhd. one does not. This question requires diaWgneoshtaicvse oaflrtehaedpyulrmeaocnhaerdy fdairseiansest,haendroethnetgreenwoleogariec mofakthinegdcioffnicsutaltnietsprtohgerreesisn. Wasetoareseavlesoralawoafreth, ehodwiseevaesre, ggeronuoplosgircefeexraremdintaotioanbowvee. mTuosgtedtheverelowpitohthtehre clrioneicnatl 328 MEDICAL efuxnacmtiionnatidoinagnmoestthicosd.s,Inespitesciamlloyst thaedvpahnycseidolofogircm,luwnge halal,teintothaeppfliyeldit enxoatmoinnalytioinns ltaobotrhaetoreixeasmbiunta,tioabnovoef poApubloavteionallg, rwouepsneeexdpoaslseod itno tdhifisferfeienltd ekxepeonsuirneste. rna ttoioneaxlchcaonllgaeboinraftoiromnattoiosnolsvoe tohuart ceoamchmoonf upsroibnlehmiss oawndn caolruenadtryy pcoosusledss aptoplythein bpertatecrtimceenttheofknoouwr lewdgoerkiwnge population. BIBLIOGRAPHY General 1. Pneumoconiosis Abstracts, Vol. Ill, London, 1959. 2. pSatahnicees spprocfiaelsesiocnoenlsleacsr(Sl ilicol'setudexecedpetsep).neAurmcho, mal. prof., 18:253-354, 1957. 3. Almlbeasharpyo,sCs.: pLoeusr alsethumr erspparroafteisosnio.neAllrecsh:. pmroabl. 4. pArlotsf.h,u7le5r.,41,B63;3,Y1a9r5m7.us, L.; Palmes, E. D.; and Nreeslpsiorna,torNy.: trAacetr.osAo.lMd.Aep. oAsirticohn. Iinndutshte. Hhueamltahn, 5. 7A7n.2d9e3rs,, 19W57.:. Soziale Probleme bei allergischen EOrffk.raGneksud.ngdeinenasmt, 7B9e:4is8p8i,el19d5e8r.Asthma bronchiale, 6. oAfnddeirssaobnil,itWy . iHn .,caonadl Smcihnmerisdt,wWith. F.c:hErovnailcuaptiuoln- ' monary disease. J A.M.A., 777:145, 1959. 7. AInnjetwcteiiolner,voHn.:StaMubasstuzseplelennsiounnedn. AHricshta.mGinewenrabceh8 pBaatahd.,er1,6E:6.0W1,.:19E59in. ige neue Probleme der Gewer bmeopdauthr)o.loBgeiieh.(Lz.unZgbel.neAmrbpehiytssemmed, .,KHademftiu3m. D, aDrmes 9. sBtaerdkt,so1n9,5J6.,: pT. h1e72s.tatistical investigation of smok MingayoanCdlinc.a,n5c4e:r20o6f, 1t9h5e9. lung. Proc. Staff Meet., 10. BLekrlainrt,idnRianggneanr,: 55Y:3r1k5e7s-p3n1e-u7m1,o1k9o5n6i.oser. Svenska 11. BBearldnianrdi,-GAr.:iffAitshtsh,meMpmro. feCs.s;ionCehlapmaprecixo,ntaJc.,t aavnedc dAersch.mmoiasli.sspurroesf.,(a75:p2r7o2p, o1s957d.e 24 observations). 12. fBuhgigyki,eBit.:dBereiLtrugnegez.uMr FurnakgaevddeerlSemta,ub5:r4e9te,n1ti9o5n7.s 13. FCraonuccehlltam, aLn.,DRe .;C.;LBfafaledre, r,WE..; WW.;oCrthho,uxG,.;J. aDned; Zmoernnt,arOy.:oInndcuusrrtreinatl pdrisoebalseemsso.fDtihse. Cchheesstt:, a32c:6o8m3, 14. C19a5r7s.tens, M.: Die asthmatischen Reaktionen der Bergleute. Arch. Gewerbepath., 75:45, 1956. 15. ECmarpstheynsse,mMu.:ndZBurronFcrhaigties ddeerr BKeragulseaultiet. tArvcohn. Gewerbepath., 75:285, 1957. 16. Dhoarusttr,eWba.n: dLe,unLg.;deBpoecskitmioannno,f fHin.;e daunsdt pWaratilckleens. A.M.A. Arch. Indust. Health, 16:119, 1957. 17. pDhayvsiiecsa,lCp.roNc.e:ssD. eIpnosthiteionSyomfpdousisutminotnheInlduunsgtsr:iaal PLuolnmdoonna, r1y96D0,ispe.as4e4s., ed. by King and Fletcher. 18. Dntianlndeiarg, noLs.e: dKelrinLisucnhg-reonnktrgaennokhloegitisecnh.e StDutitfgfearret, 19. D195n8,nepr., 3L62.:. Emphysem bei Staublungenerkran kkuranngkehne--it. EZmblp.hAysrebm. maelds., s7e:l1b3s7t, n1d9i5g7e. Berufs -- PRACTICES 20. kDrannnkeurn,gLen.: PdneeruLmuoncgoen?ioKsernitioscdheer SBtaeutrbalcuhntguenngeern umnedd.,V9o:r1s2c,hl19g5e9.zu ihrer Entschdigung. Zbl. Arb. 21. rFeeirninig,unJ.g, daenrdLuUnlgehelovvon, SVta.:ubLuenbderihdriee BSeesltbimst m19u5n9.g in Tierversuch. Arch. Gewerbepath., 76:630, 22. Fchlertocnhiecr,brCo.ncMhi.t:isDiinsabreilliatytionandto mduosrttaleixtypofsruorme A.M.A. Indust. Health., 78:368, 1958. 23. Fmloectcohneior,sisC..InM.t:heRaSdyimolpoogsiicuaml doinagInnodsuisstorifalpnPeuul dmoonn,ar1y96D0,ispe.as7e2s., ed. by King and Fletcher. Lon 24. GanedrnVezo-iRsiine,uxC,.: CAn; oBfatelgnaiunnerse,coEg.n;izFedoumrnaineirf,esPta., tfiaocntioonf ponfeupmseoucodnoitousmisorianl mfoinremrsa:tioansse.ptiScemliqaumee Jh.oAp..M.AP.a,ri7s6,7:25144:10,08119-5180.89, 1958 (in French). 25. aGuefrsivnegr,scRhi.e: deDniee fSrtahuebnartReneakitmionveenrgdleeirchLenudnegne 26. TGilermvemrseu, cJh.,. aBneditrS. wSeinlisksoosne,forsc: hO.,m42a:1n,dr1a95p6n. euNmoonk-osniliiocsoetricanpnseiluikmoos.coNnoiorsdi.s.MPedro.,c.58X:1I9I73,Co19n5g7r;. 27. IGnodeutzs,t. AH.,eaalnthd, 3T:s1u6n5e, i1s9h5i,7. N.: A Bacteriological IInrrdiutastti.onHeAalnthal,o2g0u:e16f1o,r19A5e9r.osols. A.M.A. Arch. 28. mGoracuobninoesri,s.EP.:raCcolaosnsiifilceaktaiornstvSi,ys7te8m:10o9f, 1th95e8.Pneu 29. mGerodn.eWmsecyherr.,, W85.::30D,as19g5e8w. erbliche Asthma. Dtsch. 30. GParothsos,loPgaicual:l Casuprercetsn.t Jc.oAn.Mce.pAts. 7o7f2p:5n4e6u,m1o9c6o0n.iosis. 31. pGnreoussm, oPcoanuilo: seAs.n Aim.MmAun. olAorgcihc. aIpnpdrouastc.h Htoealtthhe, 27:228, 1959. 32. dGirsotsrsib, uPtaiounl, oafndmSinmeirtahl, Kdu. sWts .:inThsoemteoppongeraupmhoic33. cHoingigoitnics, lIu.nTgs.. TDi;s.CCohchesrta,n5e5, :A14.0L, .1;9G59i.lson, J. C.; raensdpirWatoooryd, Cd.iseHa.s:e.PoApulcaotimonpasritsuodniesooff cmhirnoenrisc, fBoruitn.dJr.ywInodrkuestr.s,Maendd.,o7th6e:2r5s5i-n26S8t,av1e9l5y9,. Derbyshire. 34. nHkoulnstgeeinn,. LEe.ipz(iHge1ra9u58sg(eTbearg)u: ngHianubElurnfugretn, e1r9k5r6a)-. 35. Hofotlht,e PL.uFn.g: CPanuesuemdobcyonDioussist.. LInodnudsotnr,ia1l95D7i.seases 36. gHryadde.,MLeedr.o, y2:6:2D0i8f,fu1s9e59p.ulmonary fibrosis. Post 37. Jbluttnegne,neKr.krWan.,kuanngdenK, lBosatnerdk3t.teDr,arWm.s:taDdti,e 1S9t5a8u. 38. tKhhevaepffile,ctMo.f: iBnidoucshtermiailcadl umstetohnodsthein oragssaensissimng. Higiena Truda, 4(4):28, I960. 39. tKhheupknheruinmao,cEon. iVos.:isMinectihdoednsceu-rsaetde.iHn igthieenastuTdryudoaf 40. 4K(i4n)g:7,, E1.96J0.., and Fletcher, C. M. (eds.): A Sym pPoossitugmradounateInMduedstirciaal lScPhuoloml oonfaLryonDdoisne,as1e9s5.7 Tanhde 1958. Churchill Ltd., London, 1960, (273 pages). 41. lKuinngg, tEo. Jd.u,sat.ndInHathrreisoSny,mCp.osViu.:mReoanctiIonnduosftrtihael Pdounlm, o1n96a0r,ypD. i3se7a. ses, ed. by King & Fletcher, Lon 42. JK.leCinhrfeolndi,c MDi.s,.,a9n:d111G,ie1l9,59C.. P.: Pneumoconiosis. NORO 329 43. cKhluonstgeernkttbeer,r dWas.:ReTiniiegruenxgps'evreimrmengteelnledeUr nLtuenrgsue. Arch. Hyg., 141:258, 1957. 44. pKaogvens)a.tsRkye,viMew.eAd:.:HSiigliiceantaoseTsr.uMdao,sk2v(3a),:6109,5719(5187.9 45. LaearBoseollles,. CII.., aenffdectBsrioengerra,teH.o: fScylneearrgainsctiec ferfofemctsthoef lung. AM.A. Arch. Indust. Health, 20:100, 1959. 46. lLimagitzees, sMur. lPe.:plLaan mmaldaidciaele.asAthrmcha.tiqmuael. eptrosfe.s, 47. L18a:n2e5,5,R1.95E7..: Chronic bronchitis and occupation. Brit. J. Tuberc., 52:11, 1958. 48. pLoalwluthtieorn, Pa.ndJ., luanngd Wcaanlcleerr., RTr.anEs.:. AAstms.oIsnpdheursitc. 49. MLuepdu. ,ONff..,G9h:5.;, V19e5li9c.an, C.; and Olinescu, V.: The aucptoionn tehxeertaedddbymucceortpaoinlyspancecuhmaroidceonicootnictefnatcstoorsf 1p6u:l2m4o4,na1r9y59.macrophages. Brit. J. Indust. M ed, 50. NLobrdlimcha,nnH, .-JM.;.: KoDcihe, RWe.s;orSptfiofgne, eKin. veHrl.;eibatnend Sstteaiunb,esT. aFleki,nkRurntiilg)e. SBteaiutbr.e (SKilaiklkossepfaotr,sSchp.a,te5is0e:n1, 51. L195b7l.ich, H.-J.; Koch, W.; and Nordmann, M : DfniaehmReesvoornptiKoineseelignuvre. rBleeiibtrte. nSthSktoasuebfeosr.schD.,ie50A:1u1, 52. M195a7rc. hand, M.: Pneumopathies professionelles non steerlnraotgioenneasl. ECsosnagi rdeses cloanssifOiccactiuopna.tiPornoacl. XHlelalItnh, H17e0l-s1i9n1k)i., V1i9d5e7:, M1:1a5rc7h(aBndib,liMog.:raLpehsyppnoesutm1o9p5a0t,hpieps. pprnoefuemssoiocnoenliloesse.sAnrochn. smelalr.ogpernoef.s,. 1A8r:c2h60. ,H1i9g5.7R; aLdeas 4IV:4.0L2,ill1e9,531;95H5y(gBiinbelioegtraspechuyriptp.d2u8-T54ra).vail, Fase. 53. Mtoxairckist,y J.o,f adnudstNwagitehlscuhsmeidot,f Gth.:e Sitnudvyitroof tdhee hHyedarlotghe, n2a0s:e383t,ec1h9n59iq. ue. A M.A. Arch. Indust. 54 EMmaypehry,seEm.,a.aJn.dA.MR.aAp.,pa1p6o5:r1t,22I7.,: 19B5r7o.nchitis and 55. MMoorrrkoewn,, DP.. AE..:; AMneEhxrhpoefr,imEe.;ntCalasSatruedt,y Lo.f AJ.e;roasnodl IDnedpuossti.tiHonealitnh, 1H8u:2m92a,n 19S5u8b. jects. A.M.A. Arch. 56. iMn optlneeyu,mHo.coLn.i:osPesu.lmJ.oAn.aMry.A.f,u7n7c2ti:o1n591i,m1p9a6i0rm. ent 57. ANtatgyeglaslcleh,mDid.;t, anGd.; YNoeglasnoant,haEn., MS.;: TKhineg,recEo.veJr.y; oraftsq.uAarMtz Aa.ndArocthh.erInmduinset.raHlseafrlothm, 7th6e:18l8u,ng1s95o7f. 58. Npneesuism, oAc.onJi.o:sisM. eGthigo.dsTroufdax,-r7a:y22,ex1a9m59i.nation in 59. RNeosrodrmptainonn,eiMnv.;erKleoibchte,nWSt.a;ubanesd. SMptdsetar,dieEn.:reDinie eBreitgr.emSiilsikcohsteerforsScth.u,b6e5::21K, i1e9s5e9lg.ur und Quarz. 60. NOereunmsotecionn,ioAsi.s.J.:MeUdlitciimnaas dIenlvesTtirgaabcaiojon,es24s:o1b9r0e, 61. P19e5m9.berton, J.: Chronic bronchitis, emphysema Aannd ebpriodnecmhiioallosgpiacsmstuindyb. itAum.MinAo.usAcrocahl. wIonrdkuesrst.. 62. HPeenadlethrg, r7a5s:s5,2E9,. 1P9.:56T. he Pneumoconiosis Problem wSpitrhingEfimelpdh,a1s1i1s., o1n958t.he Role of the Radiologist. 63. Ptrroidnucic,tiFonra.nAk:.MS.tAa.tuAs rocfh.thIendpunset.umHoecaolnthio,s7es8.:3I6n1, 1958. 64. gRleaisnb,lHse.r, aenidn BLriunnkgmenaenmn,phOy:seBme?komBemreunfskHraonhkl Wheitreznburing, 1d9e5r9.keramischen Industrie, Heft 6. 65. nSiaonsdese--r, cOlin. icAa.l: aCspuercrtesn. tJ.cAo.nMceAp.t,s 7o7f2:1p5n8e7u,m1o9c6o0. 66. oSfanthdeer,pnOe.uAm.o: cNoenwioesresco(nTcheepts19o5f8tRheampaatzhzoingienOersais tion). ]. Occup. Med., 7:7, 1959. 67. cSoannioo,sisT.a, nadndtheOirsapnaatih,ogHe.n: esTisy.peRsepoofrtspnoefumthoe 68. ISnasrtt,orfeolrli,ScEi.e,ncaendofSLcoatbtio, uPr.:(TSotukdyioo), s5p5e:r2im7,en19ta5l9e. ee sdtaetlils'ticeonfsiusellm' aincpidoelmnzoanadreellanberlloancphoitpeoclarzoinoincae (oMpeirlaani o)d,i48u:n70a4,m1i9n5i7e.ra di pirite. Med. Lavoto 69. Sbecrhunfesibdeedr,ingHte.:n EUmntpehrsyusecmhusnguennd dzeurr bFerraugfsebeddeis fnsgktre.ninEdm.pkheyrsaemm.bur.onGclhaist-iIsndd.e,rHGeflat s2b.lWseur.rzBbeurrug-, 1958. 70. ASctmhnuenidgesro,rgHan.e: , Dinie Fb.erKufoleiclshceh: EHrkarnandkbuunchg ddeerr B(Leirtuefrsakturarvnekrhzeeiitcehnn,is2.S.A1u1f0l.9,).Jena, 1959. S. 620 71. SBcahyneernideirn, Hde:n DlieetztSetnaub50lunJgaehnreernk.raSntkauunbg, en20.i1n, 72- S19c6h0r.enk, H. H.: Status of the pneumoconioses, Henevailrtohn,m78e:n3t6a5l, 1f9a5c8t.ors. A.M.A. Arch. Indust. 73. Sflrammmeka,tioJ.nsanodf Strhetekr,esJp.:iraCthorroynitcraicntduasntrdialpuinl 74. mStorencakreyr,eFm.pJh.:ysDemiea.inPtrraapce. rlietoiin.,e7a0le:15G6e,w1e9b5s8t.reakAtiobnwaanudfluSniCgbd-furericehn gLeurinnggeenkQouhalrezsbtaeuimb eunngudngiherne. Beitr. Silikoseforsch., 43:21, 1956. 75. iTnatrrgoadmucatdiozne, Kof. Sd.:usOt n totheaninimtraalcsh.eaGl igm.etThrouddaof, 2:56, 1958 76 Whauosr,th,L.G; ;aDndurbNene,rreHte.rH, .;WE.:llerZsuicrk, FWrag.;e Gvaostn BUrnotnecrthaigaelsbpeatsrmieben. Bebietir. SKiloikholesenfboerrsgcahr.,be4i3t:e1r,n195im6. Asbestosis, fibrotic lung diseases, and "benign pnnoenu-smiloiccaondiuosstiss" caused by silicates, m ixed or 1. dCuosatl. WHeoarlktehr,s1P5(n6e)u, m19o5c7o.niosis. AM A. Arch. In 2. AKdoerulbnadhsrc,hmGe.:lzeLru(nBgeernuvfsekrranndkehruenitgeondebreiSueiicniedm). 3. MAhsclmhra.rkU,nAfa.;llhBkr.u,c6e0,:6T5.,; 1a9n5d7. Nystrm, A.: PneuNmoorkdoinsikosM(etadlikcoins), v59id:287b,ea1r9b5e8t.ning av taljsten 4. mAohclmonairoks,isA.i;nBriurcoen, Tf.o;unandrdieNs.ysPtrromc., AX.:IIPnIenut 5. ACohnlmgra.rkO,ccAu.p; .BHruecael,thT, .H; ealnsidnkNi,ys7t:r36m5,, 1A9.5:7.Pneu5m9o:2k8o9n,io1s95h8o. s kiselgurarbetare. Nordisk Medicin, 6. TAalvlcisoastioss,ofGu. nPus;uPaollnytiraakpisi,dAd.evEe.;loapnmdenTte.rzBirsi,t.BJ.-. 7. IBnodbuislet.vaM, eAd..,X7.2:e4t3,al1.:95X5.he A m ount of D ust in RtheesiCdehniltdiarel nDs iHstreiaclttsh.ofGiAg.sbiesLtanan.,d23i(t9s),E1ff9e5c8t. on 8. BAosbhelisgto,seHd.;erJaLcuonbg, enG..;StaunttdgarMt u(Tllherie, mHe).,: 1D96ie0 (166 pages). 330 MEDICAL PRACTICES 9. SBchowhleigrs,pHat.m: uSlclehrw. ePreroMc.isXchIsItaIunbts.iliCkoonsegrb. eOi cecinuepm. 31. dPeriosplaevrio,raGto.,rianddelBcaersmi,enCt.o:. SRuallses.pnmeeudm. oicnodnuiosts.i, 10. HBreiadlgteh-,DHaveilss,inSk.;i, a.3n:d31N0,a1g9e5ls7c.hmidt, G.: A report 32. R(Taoikrilnino,),N2.6:T16.:, 1M95a7t.erials characterizing the na oinn tphuereabsliemnecsetoonfep, nBeurmit.oc]o.niIonsdisusatm. oMngedw.,or1k3e:r6s, tKuarreagoafnpdnaeuBmasoicno.nGioisgi.s Tinrutdhae, c3o(4a)l:4m8,in1e9r5s9.of the 11. D19j5u6r.icic, I , and Savic, V.: La microhematurie des 33. Sataidoknovosfkathyea, dNu.stI.:faActocrosminpapralatinvtes hpyrgoideuncicinegvadliuf oPurovcr.ierXsIIdaInnst.unCeonmgri.neOcectupu.neHeuaslinthe, dH'aeslbsiensktei,. 3.324, 1957. 34. Sfearnednetr,typOe.s Aof.:ceRmoeenntt.gGenig.RTersuudrvae,y3(1o)f:39C,em19e5n9t. Workers. A.M.A. Arch. Indust. Health, 77:96, 12. EunhdrhPaardtht,olWog.i,eadnedr OHcekideersmtaaunbnl,unWge.:. AZrucrh.KGlienwiee-r rbepath. Gewerbehyg., 37:504, 1959. 35. S19c5h8m. idt, K. G., and Lchtrath, H : Die Wirkung von frischem und gebranntem Kaolin auf die 13. kIuenhgree,n Win.f:olglieebebrerudfloipchpeerlseiStitaguebePinlweuirrkavuenrgkeanl. SLiuhnkgoesefournsdch.,da5s8, B19a5u8c.hfell von Ratten. Beitr. 14. FGoarutsncehrr,. HR.o: nDtgieenRsturs.s,-#L5u:n16g,e 1in956ih. rer Abgrenzung 36. SHe.eleEr.,: AT.alcO.p;neGurmyboocsoknii,osJi.s.SA.;.Ma.nAd. AMrcahc.MIanhdouns,t. Hvoenaldthe,r HAenltshirnakkio, s3e:.35P6r,oc1.9X57I.I Int. Congr. Occup. 37. SHeepaklet,h, 7G9..:392Z, u1r959T. alkumstaublunge. Tuberk 15. mGolcmonmioes,isJ,,(GanradpShwitoensisss,on,KAao.:liNnoosnis-s).ilicPortoicc.pnXeIuI 38. uWloastesaornz,t,A7.4J:2;47B,la1c9k6,0.J.; Doig, A F.; and Nagel 16. lGnrto.ssC, onPg.;r. WOcecsturpic.kH, eMal.thL, .H; eMlsicnNkei,rn3e:y1,66J,. 19M57.;. sMchamkeirdst., BGn:t.P]n.eIunmdoucsot.niMoseids.,in76C:2a7r4b,on19E59lectrode Sefcfhecretsncokf, Hsy.nHth.;etaicndsiSlircsaicte, sR.dePr.i:vTedhefrpoumlmdoinaatorymaceous earth. A.M.A. Arch. Indust. Health, 39. LVuysnkgoecnilf,unJk.t:ionDenynambeiischZeemVeenrtanrbdeeirtuenrngendurdcehr wiederholte Untersuchungen nach 5 Jahren erwie 17. 1H6u:3d1s7o,n,19J5.7.H.: Dust from Cement Works. Med. sen. Pracovnt lk., 8:85, 1956. s!:- 18. HOfufibcnere,r,98O:.3,5a1,nd19M57; lJle.Ar,.MG..A: .,M7in66er:1a3lo5g8i,sc1h9e58u. nd Pneum opathies due to toxic chemicals and metals 1. Beryllium Disease and Its Control. Conference physikalisch-chemische Untersuchungen an einer held at Massachusetts Institute of Technology TAraclkh-.SGtaeuwbelurbnegpeatuh.n,d44a0n, 1T95a7l.k-Hautgranulomen. 7S9e:p9t1.-3206-7O, c1t9.519,. 1958. A.M.A. Arch. Indust. Health, 19. Kthaembmiteurm, Ain.oGus.: cOoaclcumpaintieorn. aAl.Mhe.aAl.thAprcrohb. lIenmdsusotf. 2. Agumindeuar, piMgsaryto Osu.:lfuTrhice arceidspimraitsot.ryA.rMes.pAo.nsAercohf I;tfs$- 20. HKoeeallstchh,, 7F5.::46Z6u, r19F5r7a.ge der "Graphitstaublunge". Zbl. Arb. med., 8:1, 1958. 3. IAnrdcuhsatn.gHeleskaaltjha,, 1L8:.40N7,. 19&58.Borisenkowa, R. V.: Untersuchungen ber die hygienische Bewertung 21. ZKbole.lsAcrhb,.Fm.: eDd.i,e9S:1ta5u3b-1g5e7f,h1r9d5u9.ng durch Flusspat. 22. Kiviluoto, R.: Pleural calcification as a roent vHoyng. IEnpdiuds.trMieisctraoubbiola.uIsmmMuentaolll.-L(ePgraiegruuen)g,e7n:.44J1., 1957. a gpehnyolllioteg-iacsbseigsntosoifs.nAonc-taocRcuapdaiotilo.,naSlupepndl.em19i4c, a1n9t6o0-, 4. MBaeadd.eSr,acEh.veWrs.t:.,L3u2n:1g2e8n,s1c9h56d.en durch Isozyanate. ;sf 23. L(6i7icphatrgaecsh).t, H., and Schmidt, K. G.: Ueber Talkum und Steatit, ihre Beziehungen zum Asbest 5. Bblauandgeern, eErk. rWan.k: uHngaretnm, eBtaalln-dLu3n.geEnd.. Ibny DJietteSntau& Klosterktter, Darmstadt, 1958, p. 531; Zbl. Arb. svoewrsiuechiharen WRaitrtkeunn. gBebietrim. Siilniktroasterfaocrhscteha.,le6n1, T19ie59r. 6. mBaeadd.,er9,:3E3., W19.5:9N. eues ber die wichtigsten Beru 24. NLobrdlimcha,nnH, .-JM.;.: KDocieh, RWes.;orpStifofnge, eiKn.v-eHr.l;eibatnend fskrankheiten. Sichere Arbeit, 7:23, 1960. 7. Barth, G.; Frik, W.; and Scheidemandel, H.: Die S50ta:1u,be1s9.5F7.einkrnige Stube. Beitr. Silikoseforsch., A19l5u6m. iniumlunge. Dtsch. Med. Wschr., #7:1115, 25. HMaassss.iomneed, .RI.n,daunsdt., L(Tuvoorinnio,),R2.:5:S1,ili1c9o5s6i. da Mica? 8. ABe.;ckalnakde,FMre.ckR, .;C.GoCl.d: mTahnen, lHon.gI-.t;erRmae-eBffoecstms aonf, 26. PMreoick.leXjoIhIn,IntA. .:CoCngarr.boOnccuapn.d Hpenaeltuhm, oHcoenlsioinskisi., e7x6:p3o9s8u,re195to7. nitrous fumes. Am. Rev. Tuberc., 3:335, 1957. 27. mMoenssairtey, ]t.a;lcRoseisd,dina, cGli.;nicaanld aKnldeinefenlvdi,roMnm.: ePnutall 9. wBeitnhoisatr,gCon. -Pa,,rcahndweFlrdainntg,. RP.:roMc.edXicIaIl Ienxtp.erCieonncgers. Occup. Health, Helsinki, 3:387, 1957. study. A.M.A. Arch. Indust. Health, 20:408, 1959. 28. Mongelli-Sciannameo, N.: Su la patologia da 10. BHi.s:teZr,urF.G; eKwlaevrbise,toGx.i;koKloghileerv, oHn.;AannstdricWhsistttgofefnesn, auf Zinkchromatbasis. Arch. Gewerbepath., 76:567, p3o50lvceeremednitisctei.mFeonltioa Mrileidevicia,c4li2n:i4c6o9-,ra1d9io59lo. gici su 11. B19l5o8o.m, G., and Swensson, A.: The reaction of the 29. RNeosrodrmptainonn, Mei.n;vKerolecihb,teWn .; SatnaudbeMs.deSrp,tEs.t:adDieine sthiornosmboofcytseusbmtoicrionstcroapviecnoupsalryticliensj.ectAedctasusMpeedn. rKeiienseerlguunr dungdemQiuscahrzte. rBSeittru.bSei:likKoiseesfeolrgsucrh,.,Q6u3a:2rz3,, 12. BScoacncdia.,, 7D6.2::4P23a,to1l9o5g8i.a de la soldadura elctrica. 1959. 30. Pattle, R. E.; Wedd, G. D.; and Burgess, F.: The 13. MBoendn. eTllr,aJb.aAjo.,; 2K3a:1z6a,nt1z9is5,8.G.; and King, E. A.: A Maceudte., t7o6x:i2c16e,ff1e9c5ts9.of black smoke. Brit. J. Indust. fooxlildoew-fuupmes.tuBdryit. oJf. Inmdeunst.eMxpeods.e,d76t:o135c,a1d9m5i9u.m NORO 331 14. pBirctcuhrenero,f Lpn. eu&moMcoanuitonseirs, inB.:weBldreornsc.hPograracpohvniei lekarstvi, 11:233, 1959. 15. NBoedo.t, TAs.chCr..: GVeenregeisfktu.,ng101m:2it12V4,an1a9d57iu.mpentoxyd. 16. Btiorensliinn, bAe.ryJl.l,iuamndfaHcialirtriiess,. WSu.mBm.:arHyeoaflthtenpryoetearcs o1f9:5e9x6,pe1r9i5e9n.ce. A.M.A. Arch. Indust. Health, 17. cBhuieaslse, uHn.d, aasnthdmLoeidrneeBr,roRn.c:hiUtisebinerdAerstchhmema isbcrhoenn 18. ICnadmusptbreiell., ZI.rePnreavRe.n;tivCmasesd, .J(.ZSu.r;icCh)h,ol5a9k,, 1J9.5;6.and MKeahno.e,AR.M. .AA..: AArlcuhm. inIunmdusitn. tHheeaEltnhv, ir7o7n:4m0e4n-4t0o6f, 19. C19e5m7.ber, H.; Watson, J. A.; and Grucci, T. B.: aPcutlimvaotendaryclaeyffepctasrticflreosm. Ar.aMdi.oAa.ctiAvrech.thaInlldiuumst-. 20. HCheoallathk,, 7J5.::4T49h,e19a5n7a.lysis of traces of beryllium. 21. AChMri.sAte.nAsernc,h.FI.ndCu,sta.nHdeaOlltsho,n1, 9E:2.05C,.:19C59a.dmium p19o5is7o. ning. A.M.A. Arch. Indust. Health, 16:8, 22 wCoitthter,edLa.thHa.m: iTl recaatmlcieunmt ofdicsaoddmiuimum. p]oAis.oMn.iAn.g, 166:185, 1958. 23. mCraelpaettti,a Md.a, annadvaGdiasffunreii, Epu:liAtoriprodpi osciatoldadieellaa nafta. Lavoro e. med., 10, 1956. 24 anCdurtiRs,asJm. uKsse;n,BaHue.r, KH.:elePnue;lmLoonoamryansd,ifSfuaslliioen; ccaarpbaocnity msotnudoixeisd.e Ib. reaaths-ihmoplldifiniegd. Atemch. n]iq. ueMeodf. 25. SDeai.l,h2a1m6n:5,3T, .1:9C58h.lorine dioxide toxicity in animal Ienxdpuersitm. eHnetaslthan, d75:i1n0d1u,s1tr9i5a7l. risks. A.M.A. Arch. 26. GD.eiEch.:mAancunt,eWef.feBct;sKoefpnliintrgoe-ro,leMfi.nIs,.;upaonnd Lexanpieerri, m75e:3n1ta2l, 1a9n5i8m. als. A.M.A. Arch. Indust. Health, 27. dDernschSein, teHra:nlZaguernFrasgaearldenrdiSsctahuebrgeEfisherndhungtteinn w19e5r9k.e. Arch. Gewerbepath. Gewerbehyg., 16:666, 28. nDonn-npenre,umL.o, caonndioHticarlduyn,gRle:siPonnesudmuoecotoniointihcalainndg xd-ursaty anadndSO,mfuomrbeisd-farnoamtombuicrnalingstcuodkiee.s.CliAnirccahl,. Gewerbepath. Gewerbehyg., 16:644, 1959. 29. uEnhdrlicahrebre,itHsm., eadnizdinPisibczh,eWM.: aIsnsdnuashtmrieenhygbieeniiscdheer Vscehruwtze,n2d7u6n,g1v9o5n6 I&so7z,ya1n95a7te.n (Desmodur). Arbeits 30. FCiasdchmeiru,mR,.QEu.e:ckGseilwbeerr,blAicrhseenVuenrgdifithurnegeVnerdbuirncdh u1n94g6enb.is U19e5b6e.rsCiclhatusthbael-rZedllieerfeVlde,r1f9fe5n8.tliScchhurnifgteenn Bd.ergGleeusteellsec.Vha.,ftHeDfte6uts(2c0h2erpagMese)t.allhtten- und 31. rFeriineebmel, PHh.t,alasnudreGanrohsysd, riEd: uZnudr RToohxpizriotdtukvteonn aGueswedrebrepiantdhu.,st7r7ie:4l6le5n, 19P5h6t.alsauresynthese. Arch. 32. dFerinebedlu,rcHh., anneduaLrtuigcehtrLaathc,keH.u: nGdesSucnhdahuemitsstsocfhfe. Dtsch. med. Wschr., 57.980, 1956. 33. eFirniefabcehl,e HC.,heamndikaSltieeinn, hAe.r:vZorugrerGuefneneseen dAesstdhumracsh. Vpaetrhsu.,ch7e6:6m20it, 1p9-5P9h.enylendiamin. Arch. Gewerbe 34. Fmriiubmerg,poLis.:onEindga.thaAm.Mil.Ac.alcAirucmh-.diIsnodduiustm. Hineaclatdh, 77:18, 1956. 35. Fmriiubmergi,n Lm.:anDienpocshitrioonnicapnodisodnisitnrgib. uAti.Mon.Ao. fAcrcahd. Indust. Health, 16:21, 1957. 36. AFrricbhe.rgI,ndLu.:st.CHhreoanlitch,c2a0d:m40iu1,m19p5o9i.soning. A.M.A. 37. Gvaapgoeu, r.J.BriCt..;J.TIhnedustto.xMicietdy., 7o6f:1e1p, o1c9h5l9o.rhydrin 38. FG.a:lyP,nPe.u;mRoonciehe,chLro.;niBqouueviienr,teJrs.;titaienldlePdeirfrfiuns,e L. eAvrochlu.timonal.mporortfe.,ll1e8:c3h0e1z, 1u9n57.metalliseur au zinc. 39 fGrolmmmceh,lJor,inaend dLiuoxniddger.enA, .KM.-.DA..: HAeraclht.h hInazdaursdts. Health, 76:169, 1957. 40. UGlntmermsuec,hJu.,nganedn Swbeenrssdoenn, AS.:taTuibereinxpdeerirmAenrbteelilte- sluantmgeonsperhkarraenkuvnognen,FeBraronsdili3z.iuHmewraeurksgen. .JtStteanub& Klosterktter, 1957. 41. aGlulmmtomseis, Ja.,ndandpnSewumenosscoonn,ioAs.i:s Cinasesthoef stiudnegrostseisn, ccuarpb.idHeeatoltohl, iHndelussitnrkyi., P7:r1o6c6.,X1I9I57l.nt. Congr. Oc42 Gbaormiubmos,duBs.t:. PPurlamcoovnnairyLenkoadrsutlvait,io9n:39b9y, i1n9h5a9l.ing 43. rGenracye,, Et.oxLiecBity:, Ohxaizdaersd.ofAn.Mitr.oAg.enA: rcthhe.irInodccuustr. Health, 79:479, 1959. 44. PHraogcl.inXd,ll Ol.n: t.LuCnogngcr.haOngcecsupi.nHeelaecltthri,c Hweelsldinekrsi,. 7:169, 1957. 45. IHsoacmyaa,naGte.s.MA.:.MSyAm.pAtormchs. iInndWusotr.kHeresaEltxhp, o7s6e:d23t2o, 46. H19a5m7.lin, L. E.: Siderosis. J. Occup. Med., 1:19, 47. H19a5m9.lin, L. E.: Siderosis: additional observations colveearnaingperriooodmofeemigplhotyyeeesa.rsJo. nOscixcutyp-.niMneedf.o,u7n:d7r9y, 1959. 48. sHeaasred.yJ,.HC.hLron, .anDdiseSatsoee,c9kl:e1,52J,. 1D95.:9.Beryllium di 49. Hnoassiesgaovfa, cKh.ro(nanicd Tsuelipsihnugrer,dJio.,xdidisecusinsitoonx)i:caDtiioang. P7:r2o7c1., X19I5I7.lnt. Congr. Occup. Health, Helsinki, 50. HGuewsteernb,epKa.:th.H, a7r6t:m72e1ta, ll1-9F5i9b.rose der lunge. Arch. 51. Icaanzinoanceonaec,utAa.,daandanMhiadzreildlae dmiaBleoicscao,inMl.:avIonrtaotsosri-i 52. Jdoehl npsotortnoe., LRa.v.Tu.:mTanoolue(nNea-p2o4l-iD),ii5so:4c0y4a,n1a9te5.6.clin 53. iKcaalrpfoeva,turBes.. IDn.d:usAt.nMgaebde.n, 26z:3u3r, 1to9x57ik.ologischen 2C2h:1a4ra4k:7te4r,is1t9ik57v. on Methylchlorakrylat. Gig. i San. 54. dKearspHareorvs,teAll.uAng.: PvroonblVemulekadneirsaAtirobnesiatskhzyegleieranteorbeeni 55. K(Tlaiuvrisa,mG, .:KaApmtakmso).niGakigv.ertrguifdtuan, g7e:2n4,u1n9d57i.hre Fo Algrecnh. uTnotxeircolB.,e7r7:c1k5s5i,ch1t9ig58u.ng neuer Kasuistik. 56. KUlrasvaicsh,e Gd.;er KThholemr,assHch.;lacaknednpnBeiusmtero,nieF.:unDteier bmeasnognadnehrearltigBeenrcSkcshilcahctkigenubnegstadnedrteiVlea.naAdricnh-. uGned 57. wKeleribnefpealdth, .M, 1.,5:a3n5d5,G6i0e7l,, C19h5.6-P1.9:5C7.linical manifes otaftieoxnpsoosufroez.oAnme .poJi.sMoneidn.g:Scr.e,p2o7r7t:6o3f8,a 1n9e5w6. source 332 MEDICAL 58. kKaoreblisdceh, uFn.d: GHeasrutmndehtaeliltes.schZbdl.enArdbu. rcmhed.M, e9t:a8l3l-, 1959; /. prophyl. Med. Soz.-hyg., 5:1, 1959. 59 KStuanbkileel,, DA..E.M; S;auMnduerrtsh,a,J. EP.; Fa.;ndDWikielmls,usJ,. HH.:; SAormche plnhdarumsta.cHoleoaglitcha,l 1e9f:f3e4ct6s, o1f95d6iborane A.M.A. 60. fKtuuntsgchdeurar,chWD:isEsionusegiagse.nMartiitgt,erosFtaelrlr.eiSnaenr Vveerrwgi., 61 5L7a-c2h2n8i,t,19V56.. Zur Therapie der Reizgasvergiftung. 62. LZbeilchAerrb, . Fm.:ed.Z, u8r:17D7,iff1e9r5e8n.tialdiagnose zwischen ARulunmlgineniusmtrl,uSn7g.e571u,n1d956M. orbus Boeck. Fortschr. 63. DLeisvtmrisbkuatsi,onG. aJn;dPoelxlicsr,eAti.o;nanodfNpoovriacnk,esW. .AJ.M, J.rA.: Arch. Indust. Health, 11.346, 1956. 64 AL.eMwisA, CA.icEh:. TInhdeusbti.olHogeiaclathl ,ef1f9e:c4ts97o,f1v95a9n.adium. 65 iLnisnkdagrseynn,pSunkAte.,r apnad fSrwamensstsollnn,inAg :oYchrkebsemarebdeitt-66. nLiinnggeanv, pMlaasrtieer-.LSovu.isLea,kaanrdtidSnuinngdeenil,, 5C5.2G22:7,L1u9n5g8-. jfeohraanltdigrinlugfatr NlaokrtdtiasgknaMeedfitceirn, i5n8a.n1d97n4in, g195a7v. ol67. (Lboowraen,e)H.inJto,xiacnadtioFnrememmana,n.GA:.MBoAr.onArhcyhd. riIdne 68. dMuasct.haHbeealil,thM, 16E:.5;2G3,dz1e9l5d7z.e, E. G.; and Mgeladze, Tm.anGga.:noCkolinniiocsails. pGicigtu. rTeruadnad, 1w:4o8r,k19c6a0p.acity in 69. lMunagn.n,BrBi.t. TM.,eda.n]d., L2e:9c2u1ti,er1,95E7.. R.: Arc welder's 70. Mtoxarickist,y Jo.f, daunsdt wNiathgelusscehmofidtth,e Gin.: vSittruodydeohfydtrhoe g2e0n:3a8s3e, t1e9c5h9n. ique. A.MA. Arch, lndust. Health, 71. Mbaesrsmdainen,biWolo.:gisEcxhpeerWimireknutenlgle vUonnteVrsauncahduinnvgeern 72. Mbinasdsumnagnenn,. WAr.:chT. ieTroexxipceorli.m, 1e6n:t1e8ll2e, U19n5t6e.rsuchun genen, dibeer bdeiie Stocxhiwkoeilsosgeinschme iWt ikrakluknbgasivsocnheRnauEclhe k19tr5o6d.en entstehen. Arch. Gewerbepath., 14:291, 73. Mbioalsosgmisacnhne, WWirk..ungUdnestePrsoulcyhauernyglennitrils.bZe.rexpdeire. 74. MMeadss.,m7a2n7n:,40W7,.,19a5n6d. Pilgrim, K.: Das Verhalten vdoesn LMuannggeanng-eIwVe-bOexsyndacuhndinCtrhartoramc-hIeIIa-lOerxyIndj.eAktricohn. Gewerbepath., 15:203, 1956. 75. oMpcaLqauueghdluinst,s.AI.n I.theG..SyImropnosiuanmd oonthIenrdursatdriiaol PLuolnmdoonna, rIy96D0,ispe.as1e4s6,. ed. by King and Fletcher. 76. uMseeikolfejcoahlnci,nAed., aalnudmPinoasnienr, cEh.:inTa hbeisecfufeitctpolafcitnhge Monedt.h,e74h:2e2a9lt,h19o5f7.the workman. Brit. J. lndust. 77. zMuellnssikigoevna,KEa.dmAiu: mA-nguanbdenVzaunradBiuemstigmehmaultnegs ddeesr Luft in Industrieraumen. Gig. i san., 21:25, 1957. 78. dMuosztreinatlseavear,osNo.lsVo.f: wHoylgfrieanmic. Gchiga.raicStearni.s,ti2c2(o4f):2in5, 1957. 79. Mtraigndzeunr, CHa.d; mBiruumckvneergr,iftCuhn.g;. aAnrdchS. iGmeown,erJb.:epBatehi. Gewerbehyg., 77:531, 1959. 80. wMoitrckheer.ll,BJr.i:t. PJu.lmlnodnuasrty. Sfiabfreotysi,s7i6n:1a2n3,a1lu95m9.inium PRACTICES 81. oMf itotlzeorn,eS..;AKMingA,.MA.;rcahn.d lBnudruksht.arHdte,aBlt.h: ,To7x5i:1c9it1y, 82. M19o5g7.ilevskaya, O. Ya.: An experimental study of ttohrey eoffregcatnso.f Graigre. imseatna.l,s2o5r:e30d, u1s9t60o.n the respira 83. LMuonsgcehninvsekria,nGde.;ruJnugreisnch,beAi .,SainndteRrheianrl,tmWe.:taDlii-e 84. AMrobleitioterr,n.LA;rcMh.osGinegwere,rbMep.;atBha, r7th6e:6l,97J,.;19H59e.yart, dHe ; alanmd inPoeirrineet,t Gle:uRrecchaepracchiets supratlheosgponues.siLreess spiadgerso)s.es pulmonaires. Luxembourg, 1957 (127 85. LMuonsgcehninvsekria,nGde;ruJnugreisnch,beAi .;SianntderhRaertimnle, taWll.a-rbDeiie86 Ntearnk.anAisrkchi,. SG., eawnedrbNeapmaitkhi,, 7S6::6S97y,m1p9to58m.s in woke1r9s58exposed to isocyanates. Rdkagaku, 57.980, 87. sNuelfbaetl.unAgic, liW. G:eAwekrubteepaVtehr.,gi7ft5u:5n8g1,m1i9t57Dimethyl88. SOtyananngousirsen,BeInLig; nHpandeduamdo, coRn.;iosaisndowMinagasst,o Hin.- ahnadlatieoxnpeorfimtienntadlussttuadnides.fulmnde.usIt.. eMnveidr.o,nm27e.n42ta7l, 89 1P9e5n8alver, R : Diagnosis and treatment of man gAaincehs.elnidnutosxt.icHateiaolnt.h, R16e:p6o4r,t 19o5f7.a case. A.M.A. 90 mPoorntealiar-eComeqsu,elFqu:esLaprreoadcutiitosn idneduls'atrlivelos.le Pproucl. X19I5I7.Int, Congr. Occup. Health, Helsinki, 5.311, 91. ivnohnalPaotisot-nLianvgeno,ljaMearlliee-rLoouljieshea; ltLigunglusfkt.adNoor redfitsekr Median, 59.290, 1958. 92. mPootneyryapeevnat,acGh.loErid:eT. hGeigt.oTxircudpar,op2e:2r2ti,es19o5n8. anti 93. QKuloitlilnig,aPn,; JThJe.;toBxoiccihtye,oRf .ozDon.;e Ffoalrky, oLu.ngHc.;hicaknsd. A.M.A. Arch, lndust. Health, 18:16, 1958. 94. Ostoeftftee?l, AHrc.:h,Geexspuenrd. hPeaittshg.ePfahharrdmunagk.,d2u5r2c:h77K, u19n5s8t. 95. mReaisnscl,hlWac.k:e,UeVbaenraddiiensEchrklarcaknekuungnedn VduarncahdinTvheor b19in58d.ungen und ihre Ursachen. Staub, 18:143, 177, 96 oRxoibdeer.tsoInn, tAhe. JS.:ymPpnoesuiummocoonniosIinsdudsutreialto Ptuiln dmoonn,arI9y60D,ispe.as1e6s8,.ed. by King and Fletcher. Lon 97. tRreoagteerds, wWith. cNor.t:icoCtrhorpohniinc. Lbaenrycellti,u2m75:2p6o7is,o1n9i5n7g. 98. oRxoihdres., AL..MC..A: .MAertcahl-,fulmndeufsetv. eHr efraolmth,in7h6a:4li2n,g1z9i5n7c. 99. RGoifstc.hJt.scHhying,. LEpVid.:. DMaiscrVoabnioald.iIummmaulsnoinl.du(Pstrraigeullee)s, 100. 2R:o4s9c2h,i1n9a5,8.T. A.: An experimental investigation nofestihtoecharcotmiointeorfeftrhaectocrhireosmdoumstagonnetshitee baonddy.mHaigg-. 101. RTrousdmaa,n5it:h2,8,J.1;95V9.olf, J.; and Knpfelmacher, E : Rpheuspriicrataocriyd. Pdrisaecaosveniinlkwarosrtvkie,rs9.4p1r1o,d1u9c5i7n.g sul 102. RBaoSsOmjanpintheu, m].o,caonndiosKisn.oPprfeaicm. aleckh.e,r,9:E14:0,A19c5a7se. of 103. JR.oOuscht,upG. .M, eJrd..:, 7T:4h6e, t1o9x5i9c.ology of the boranes. 104. Rdeotwerem, iVn.edK.,oent ael.x:pTeroixmiceinttyalofapnriompayllse.neA.oMxi.dAe. Arch. lndust. Health, 75:228, 1956. NORO 333 105. pRouriz,quRe.roFs.,n.andThIeribMarerdeinca, lRB. uRll.:etiNneu(mStoapnadtairads 106. ROuilmCyoa.n,tsNe.vJ.,),G2.0T:3.:5,O1n96t0h.e question of barytosis. Gig. i San., 23(4): 17, 1958. 107. Sviaerwais, oSf.,duasntdprUodenuoc,edKi.n: eElelecctrtriconstemelicmroescltoinpgic. P3:r3o2c5., X19I5I7.Int. Congr. Occup. Health, Helsinki, 108. SAc.hBep.;erRs,edGli.n,WA. . HJ..;; SDchumrkiadnt,, JT. .GM.; .;CrDeeedlaohna, nFt,. Tbi.o;loJgaiccoalbsaocnt,ionJ. oWf f.;ibearngdlasB-palialsetyic, dDu.st.A.A: .MT.hAe. Arch. Indust. Health, 18:34, 1958. 109. S7.c1h4n2e,id1e9r5,7.H.: Ueber Siderose. Zbl. Arb. med., 110. Sfucehles?chNteart,. WSa.fetHy.:NeHwos,w77t:o2x8i,c19a5r8e. high energy 111. ISncdhuiislet.r,MPe.d,.,c2t 7:a4l.3:2,S1ta9n5n8.osis. II. clinical study. 112. mScehnutlaelr, aPn.,delmael.d:icMalansgtaundeyseaptoiasonCinhigl.eaEnnvmirionne Indust. Med., 26:167, 1957. 113. Seteraeln.:koS,aAni.taSr.y; Sctoannidsiltaivosnksy,ofY.wMor.k; Kanhdazpane,cuGl.iaLri., Atiegsloomf eprnaetiunmgopcloannitoss.isGmig.wTorrukderas, a2t.1t7h,e1I9r5o8n. ore 114. SSeomri.anhoo,pM., 3:4A:3s2t1h3m,e19e5x8p.erimental par l'acroline. 115. Ssmirao,g VirrMit.a,natsnd oPnattlheu,mRa.nE.:suEbjfefecctst. ofJApoMss.iAbl.e, 165:1908, 1957. 116. aSnjodberpgo,sSs.ibGle.: Vrisaknadoifumemdupshty,scehmroa,nicAbctraoncmhietdis. Scand., 757:381, 1956. 117. lSujfotbveargga,r Sm. .mG.., haonsdsoRtairgeniro,ljKee.ldGni:ngBsaensvlagrgfnrianngar. Nordisk Median, 58:1973, 1957. 118. uSrminitahr,y J.caSd.m, iaunmd Kanednchp,roJteiEn.:exOcbresteirovnatiionnsmoenn Je.xpIonseddustto. Mcaeddm, iu7m4:24o0x,id1e95d7u. st and fume. Brit. 119. SCmheitmh,icaJl. aCnd.; hKisetnocrihc,alJ.poEst.-;maonrtdemSmstiuthd,iesJ.onP:a woxoirdkemfaunmee.xpBorsietd. Jf.orIndmuasnty. Myeeadr.s, 7to4:2c4a6d, m1i9u5m7. 120. tTheebrmocakn,agHem. eEn.t, oafndchrMonaicchlbee,ryWlli.o: si-sA.dPvaroncc.esXiInI lnt. Congr. Occup. Health, Helsinki, 3:167, 1957. 121. VTherogmifatus,ngD.inL.deGr , IannddustSrtiiee.brMis,edK. .:J.VAanuastdriaulmia-, 43:607, 1956. 122. aTnhdomCarsit,chMlo.wD,,,J H: ePnrdorliocnkgse,dRe.xHpo.;suGreunonf, gFu.inDe.a; pHigeas lttoh,s1u7lf:1u0ri,c1a9c58id. aerosol. A.MA. Arch. Indust. 123. iTnimoekmhpinlo, yDm.enI t: Proofblemmasgonfesiinudmu-sttorriiaulmh-ycgoibeaniet catalyzer, Hig. Truda, 2.42, 1958. 124. T19u5r9,. J : Liderosis pulmonum. Med. Pracy., 70:33, 125. AV.aMlle.Ae,. BA.rcLh..: IZnidnucsta.nHdeiatslthb,io1l6og1i4c7a,l 1s9ig57n.ificance 126. Vcaodrmobiujemva,oRxi.dSe : JT.heHyqgu.esEtipoindeomf itohle. tMoxicicroitbyioolf. Immunol. (Prague), 2 244, 1958. 127 Zthaapnpe, Jf.oaAm.: Hplaazsatircds porfodiusocctiyoann.ateAs Min.Ap. olAyrucrhe. Indust. Health, 75:324, 1957. aPnndeupmnoeupmatohmiesycdouseesto organic dusts, allergens 1. CBorihnegnh,urJs.t:, LR.esSp.;iraBtoyrryne, dRis.eaNse., oafndmGusehrsrohoomnworkers, farmer's lung. J.A.M.A., 777:15, 1959. 2. RBeuigsysit,roBh,,staaunbd. MBeoiltnra.r,SiLli.k:oLseufnorgsecnhs.c, h51d:e3n1,d1u9r5c8h. 3. B70u:g2y0i0,, 1B9.5:8.On Conionmycoses. Prac. lekarstvi, 4. Calhvienoalcahr omtii,crNol,,ithiaansdis aTsasnogcicahteadi, wPit.:h tPhuelminohnaalray t1i9o5n7. of snuff in Thailand. Dis. Chest, 32:687, 5. EDxapSeilrviameHnotertlale, J.,KaonrkdstDauebkCoanrvioasleho C(Eanxcpeelrliam, eLn.: telle Suberose). Arch. Gewerbepath., 75:319, 1957. 6. DGetnrneiedre, Lun.:d PSnaeautmeno.koInnioSsteanubdluunrcgheneSrtkaruabnkvuonn gDeanr,mBstaanddt, 139,58e,d.p.b5y41J.otten and Klosterktter. 7. aDnickaiceu,teH.graAn.,uloanmdatoRuasnkininte, rsJt.i:tiaFlarpmneeursmolnuintgis o10c6c9u,rr1in95g8.in agricultural workers. J.A.M.A., 167: 8 cFornanioks,isRd. uCe.: toFaromrgearn'sicludnugs--tsa Afo.r}m. Roofepnntgeeunmolo., 9. 7F2r.o1s8t9, ,J.1,95a8n.d Georg. J.: Taerskerlunge. Ugeskr. 10. LGaroeegt,sc7h7e8l,:1H383, ,an1d95T6.rense, E.: Tod eines Druck NerassszaenrstAusbthemmaitteblnr.oncAiracleh. nGacehwerUbmepgaatnhg., m16i:t 11. G37u5p, t1a9,58A.. S.; Ferris, B. G.; and Rao, M. N.: AO.xMygAe.n Acorcnhsu. mInpdtiuosnt.oHf meaallteh,In2d0i:a9n6,ju1t9e59w.orkers. 12 oKgleunnekseer,deWs .s:ogZeunraFnnrategne Bdearcherti-oulongdieMuunldlerPaastthh- mas. Schweiz, med. Wschr., 87:714, 1957. 13. eKtiyoulnogg,icVal. Afac:toDruosft oofcctuhpeatkiounkaklerpsniteeumshoacleonaiossaisn. 14. LGoigw.ryT,ruTd.a,, a3n:4d4, S1c9h5u9man, L. M.: "Silo-filler's JdiAseMaseA"--, a76s2v:n1d5r3o,m1e95c6a.used by nitrogen dioxide. 15. ME.-urrAany, oRut;brDeiankgwoafll-Fwoeradvyecre's, Ic.o;uagnhd aLssaoncei,atRed. 1w1it1h05ta, m19a5r7in. d seed powder. Brit. J. Indust. Med., 16. ePiensetarlozMzio,dCel.l:scFherebirnielereiGrduuprpcehnerIknrhaanlkautinognenvoinn mwaitsseSrch(iBmemfeeulpchiltzeernfiekboenr)t.amScinhiweeritze.mMBede.feWucshctherr, 89:710, 1959. 17 EPoxlpieakri,mKen;teGlleuthUerntt,erHsu,chaunndgeSnchzaunzrenFbraacghe, dHe.r: Gbeehtryegid, es7t7a:u5b1l9u,ng1e9.59Arch. Gewerbepath. Gewer18. Ranodache,nvSi.roAnm, aenndtalScshtuildliyng,ofR bySs.siFn.o:siAs cinlinitchael L77an1c,as1h96ir0e. cotton industry. Biit. J. Indust. Med., 19. sSics.hiIllningth, eR.SySm. pFo.:siTumhe oenpidInedmuisotlroigayl Pofulbmyosnsianroy Dp.ise1a8s5e.s, ed. by King and Fletcher. London, 1960, 20. Ssics--hilalidnvge,nRtu.reS.aFnd' mThiseadevpeindteumreio. lJo.gyOcocfupb.yMssiendo, 7-33, 1959. 21 Sertso.ttB, rHit..: JP. uInlmduosnta.ryMeddis.,ea7s5e:2a3m, o1n9g58st. sisal work 334 MEDICAL 22. Scemnetrtaantiionn, Nof. tIh.:e Tloheess mduaxstiminal thpeermaiirssoibflecocttoonn spinning plants. Gig. Truda, 3:53, 1959. 23. Traiylloenr, mJ.illR. .:TrAanns.inAvsess.tiIgnadtiuosnt. oMf ebdy.ssOinfof.s,is7:i1n57a, 1958. 24. TMootrtaenn,, TR.. JS..:; FRaerimd,erD's. lHun. gS,.;reDpaovrits,oHf .twDo.;caasneds Jin. Mwehdic.,h 2l5u:n80g3,bi1o9p5s8i.es were performed. Amer. 25 Tuffnell, P. G., and Dingwall-Fordyce, I.: An iBtnorvitleh.setJig.ianIthinoadnluastitin.otnoMoetfdh.e,tama1c4au:r2ti5en0d,res1se9pe5id7ra. tporreyparreaatciotinosn. 26. SW:assReercmhaenrcnh, eMs .; eBxupgeeriamg-eMntiahlaeisl, Gco.;nacnedrnaIonstub"alsa, Pmraolca.diXeIIdeIsntf.ileCuorsngert. Odecscutpis.seHuresaldthe, cHhealusvinrek"i,. 27. W3 3e7g4m, a1n9n5,7.T.; Galletti, P.; and Amrein, H. P.: 8B8a.u43m1w, o1ll9s5t8a.ublunge. Schweiz. Med. Wschr., 28 Z\ anpnroinpio, sDde(aland"FWiavsrseermdeasnnc,erMea,,lesD"isdcuesssitorna)v-: Halleeaulrtsh, dHeselssiinloksi., 7P:r3o8c6., X19I5I7.Int. Congr. Occup. Infectious and parasitai pneumopathies 1. sDisraannkdin,ocDc.upI.a,taionnd. GGeigra.siTmrouvdaa,, M2:.8M, 1.:95B8r.ucello 2. PGirtotsssb,uPrg.;h,WMes.triPc.k,HM.:. EL.x;pMericmNeenrntaely,TJu. bMer.;cualnodp7n9:e3u2m0,oc1o9n5i9o.sis. .M.A. Arch. Indust. Health, 3 1H7a3r:r1i0s9, ,H1.9J6.0:. Treatment of Brucellosis. J.A.M.A., 4. Jbuenitaekrn, . GA.:rchL.epGtoewspeirrbeenpinaftehk.,tio75n:e5n65,be1i95K7.analar 5. AKrcthh.e,GJe.:weDrbieepLaethp.t,os7p7i:r3o1s6e, a1l9s59B. erufskrankheit. 6. mKioncgo,niEo.sisJ..:PRroecc.eXntIIRIenste.arCcohnginr. IOnfceccutpiv. eHPeanlethu, 7. HKienlgsi,nkEi., 7J.:;28Y3,og19a5n7a.than, M.; Harrison, C. V.; aPnndeumMoictocnhiiososins,. DA..MA.A.:. EAxrcphe.rimInednutaslt. inHfeecatlitvhe, 16:380, 1957. 8. mRaemntsaoyf, Jp.neHu.m, oacnodnioPsiinses,coAm.:pliRceasteudltsbyof tturbeeart 9. Scuclhosipsp. eBrtr,it.RM.: edL. uJn.,ge2n.t3u4b5e,rk1u95lo9s.e als Beruf ssckhraanftkhbeeistchbefitigMteentzgPeerrnsonuennd. Zb.eidrizntl. LFaonrdtbwilidrt., 10. 5S2p:i4n1k7,, W19.58.W.: Current status of therapy of b1r9u6c0e. llosis in human beings. J.A.M.A., 172:091, 11. Tmearlziainn, pnAe.umLo.n: itisPsit(tPacOoMsisP--) orvnirauthseossisi--n mmaman, Immammumnaolls. a(nPdragbuired),s.2:J1.29H, y1g9.58E. pid. Microbiol. Lung cancer due to occupation and radiation 1. C19a5u8s.ation of Cancer. British Med. Bull. 14(2), 2. Awsokrk-Uerpsm. Dariks., CE.h:esBt,ro2n7c:4h,ia1l9c5a5r.cinoma in printing 3. fAezrihnbgel,frSo.mI.: tOoxniccapnnceeurmdoiasgclneorsoissesi.n Hpaigti.enTtsrusduaf, 4. 5B:a1r1b,o1r9ik5,9.N. et al.: Carcinoma of the lungs in e7l0e:c4t1r3o,ly1t9ic58.chromium plating. Prac. Lkarstvi, PRACTICES 5. dBiasetrtijberu,tiAo.nMa.n; dDaremteronnti,onC.;oafncdhrBoumdiaucmz, Vin.: mThene a1n95d9.animals. A.M.A. Arch. Indust. Health, 20:136, 6. BBuadetajcezr,, AB.. AM..:; ELfofewcnteoy,f Jc.hrFo.;mSiutemffeeo,nMin.Dci.d;eanncde Ionfdluusnt.g Mtuemd.o, r2s0:i1n24m, i1c9e59a.nd rats. A.M.A. Arch. 7. Bcaindcsetrru. pT,raPn.s. LA.s:s. OIncdcuuspta.tiMoneadl. Ocfafu.,se9s:2,of195l9u.ng 8. LBuonhgliegn,krHe.b,seasndbeJai codbe,utCs.c:heDnie AHsbuefsitgarkbeeititedrnes. P5:r3o0c8., X19I5I7.Int. Congr. Occup. Health, Helsinki, 9. hBerravuonr,geWru.:feKnredbusrcahn HArasuetn.unDdtscinhn. eMreend.OrWgasncehnr,, 83:810, 1958. 10. dBiraotiwonnisn.g,ElEsethveiel:r HMaornmofgurlapehfsfe:ctIsndouf sitorniaislinTgoxriac 11. ACgemenbtse.r,AHm.:steBrrdoanmch, o1g9e5n9i.c carcinoma from radio afecrteivnecepaorntictuhleatePse.acSeefcuolndUseUsnoitfedAtNomatiiconEsneCrogny. 12. CGheniuervcao,, 19G5.8.AP.-apLeravAo/rCoonef.tu1m5/oPr/i9.00A.rchivo di MVieddeicainlsao:MPurtouca.liXstIicIa,In4t:.VoClo. n1g4r,.1O95c9cu(3p7.2Hpeaagletsh),. Helsinki, 147, (Fr.), 139, (Engl.), 1957. 13. rDealavtiieosn, sDh.ipF.b: eAtwereenvieswmookfintgheanevdidleunncge ocannctehre. J. Chron. Dis., 11:519, 1960. 14. Dpooslilu, mR.:onOIcncduupsattriioanlalPululmngoncaarnyceDr.iseIansetsh,eedS.ymby King and Fletcher. London, 1960, p. 208. 15. DBroiltl., JR. .I:ndOusctc.uMpaetdio.,na7l6:1l8u1n,g19c5a9n.cer: a review. 16. D4(v3i)z:k3,ov1,96P0.. P.: Occupational cancer. Gig. Truda, 17. EancdkaLrdotn, dRo.n,E.1:9I5n9d. ustrial Carcinogens. New York 18. Efilellidn,g1e1r1,.,F1.9:57M, epd.ic2a2l4 Rffa. diation Biology. Spring19. Enisopsiinso. sM-Pedr.ezy, sDeg.:. tCraanbcaejor, p5u:5lm, 1o9n5a7r. y neumoco20. iFnidnukeclt,ioMn.iriParmoc.P.:InItn.teCrnoanlf.emPietatecresfualndUsteusmoorf A19to56m,ipc.E1n6e0r.gy, Geneva, 1955, Vol. 11. New York, 21. pGaatlhleiegso,duJ.e tDo.:duPstu.lmProonca.rXy IIleIsniotn. sCoinngrp.nOeuccmuop. Health, Helsinki, 5:378, 1957. 22. BGroiltd. bMlaetdt,. BMu.ll.W, 7.:4:1O3c6c,u1p9a5t8io. nal Carcinogenesis. 23. lGyrmospshe,knoHte.:n uMndiscLhustnaguebniknrdeubrsa.tiFornankdfe. rZ. HPialtuhs.-, 24. 6H7a:2d2d0o,w1,9A56..(ed.): Causation of cancer. Brit. Med. 25. BHualrlr.i,s,14W(2)., B19.;58.Breslin, A. J.; Glauberman, B.; aasnsdociWateedinswteiitnh, Mth.e Sm.: ilElinnvgiroonfmuenratanliumhazaorrdes. A.M.A. Arch. Indust. Health, 20:365, 1959. 26. cHaunecpereirg,enWes.is.CX.: . Ecaxnpceerrimigeennitcalefsfetucdtsieosf icnhrommetiatel ocarevitryoasotf deraptoss.iteAd.Min.Am. uAscrlceh.tisIsnudeuasnt.d Hpleeaulrthal, 18:284, 1958. 27. nIrimscshcehrerP, nGeu.:molineibeernaecihneInnhTaoladteiosfnallvoann alcphhrao- urunndd 2b0etJaashtrraehnl.enDaakstivDeemutsc"hIendGuessturinedshtaeuitbsw" esveonr, 52:1732, 1958. NORWOOD 335 28. JWamaleess, cWoa.l-wR.orLke.:rsPwrimitharpyneluunmgoccoannicoesrisi.nBSriot.ut]h. Indust. Med., 12:87, 1955. 29. eKxeongneanwoauys,faEc.,toarsndinLtihnedsceayu,saAt.ioJn.: oSfolmunegpcoasnsicbelre. Brit. Med. Bull., 14:124, 1958. 30. 5K:o1e2l9s,ch1,61F, .:195D8e. r Arsenkrebs. Zbl. Arbeitsmed., 31. tMhecLSayumgpholisni,umA.on1. IGnd.:usItrroinal aPsulamoCnaarcriynoDgiesena.seIsn, ed. by King and Fletcher. London, 1960, p. 162. 32. PMuecdc.inLia, voCr.:o, L51e:18p,ro1b9l6e0m. a della cancro-silicosi. 33. BReinrcukfs,erHkr.a:nkDuenrg. CMherodimziantiksrcehbes, 3d4e2r, 1L95u6n.ge als 34. SAerpbk.eM, eGd..:, Z7:u1m14,S1c9h5n7e.eberger Lungenkrebs. Zbl. 35. JS.mIinthd,usRt.. MA.e:dL.,u1n6g:31C8a,n1c9e5r9i.n Coal-Miners. Brit. 36. SanudndeKrminacna,id,F. JW. .F; .:DoNninceklelyl , pAo.isJo.n;inWg.estA, .MBo.Ab;. Arch. Indust. Health, 20:26, 1959. 37. JS.u; ndaenrdmaWn,esFt., WBo.;b:KiNncicakide,l Jp. oFis.;onDinogn.neAll.yM, .AA.. Arch. Indust. Health, 76:480, 1957. TREATMENT OF PLUTONIUM DEPOSITION IN HUMANS WITH DTPA -- EFFECTIVENESS OF LONG-TERM ADMINISTRATION AND ORAL ADMINISTRATION* W . D aggett Norw ood, M .D. M anager, Health Operation, H anford Atomic Products Operation, operated by General Electric Company for the Atomic Energy Commission Richland, W ashington solTuhblee repcloumtomnieunmded(Pmuax2im39u)minpetrhmeishsiubmleanambooudnyt oisf 0a.r0e4 nmeciecsrsoacruyriteo--lim0.6it pbgody(1)d.epRoigsiitdioncotnotrothlismeexthteondts. Fbyorainfsatcatnocreo, falmloiwlliaobnlse tchoanncetnhteratcioomnspainrabalier aalrleowloawbeler Tcohnecreentwraitlilonbse ofincmreaansyinogf pooutrenmtioalst ftoorxicexcphoesmuriecaltso. isnucihndisuosttorpye, sdwefietnhceth, eanexdpamneddiincginues.eHoefnscuechitmbaetceormiaelss vmeonsitenitmpmoertthaondt topohsasvibelethfeorsafterseta, tbinegst, tahned imndoisvtidcuoanl wwhhoichhaesxcaececdisdetnhteallmyaaxcimquuimredpearmdeispsoibsilteiolnimoift. Pu 239 boTrerdeatsmmealnlt,quhaenreti,tieosf offivePuem23p9lofyoeressowmheoyehaards ihnadri mcaitneedpetnhtaatacienttircavaecniodusl(yDTaPdmA)iniwstaesredmudciehthythleenemtroias-t eufrfiencatirvyeelaigmeinntatdioisncoovfePreud23to9 d(2a)t.e for increasing the ofTthhee perfefescetnivtesnteusdsyowf aDs TmPaAde into eimlimprionvaetinkgnoPwuled2g39e rviioadthoef umrianney wmheonnthtrse.atImt ewntasisaelsxotenddireedcteodvertoawapred deleitmerimnaitnioinng otfhePueff2e3c9tivveinaestsheofurDinTePAandin feicnecsrewashineng administered orally. Long-Term Administration of DTPA sitAionn eomfplaobyeoeutwh.4o hmaidcroaccucirdieentoafllyPurece2i3v9edsoamdeep3o0 omuoslnyt.hsInpirteiavliloyustlhye wdaasilytreautreidnarwyithouDtpTuPt AofinPtruav2e3n9 wspaesciambeonutof66u5ridniesin(tTegarbalteioIn)s. Ipterwamsincountesidpeerred24a-dhvoiusr paberleiodto cuanuletisosuselvyidceonncteinuoef tkriedantmeyenitrroivtaetrioann eoxrteontdheedr untoward effect appeared during the treatment. This D*Tr.heMuDrrTaPyA Wfeoirnetrh, isCesitguydyPhwaarsmakcienudtliycalssu, pPp.lOie.dBobxy f4u3l0,inYocnokoerrsd,inNaetiwngYsoarmk.pRle. cHo.lleWctiilosnonawndasamssoissttinhgelipn ptheerfoirnmteerdprethtaetiobinoaossfayrsesoufltst.heG.mDan.yBsraomwpnlesa.nd staff wamouoludntseorfvePuth2e39daunadl ipnudripcaotsiengowf heelitmheirnaotrinngotathfearier wovaesr.aancheaxntegnediend epfefreicotidv.eness of this agent when used T able I AEFDFMECINTIISVTEENREESDS DOTFPAINITNRAINVCERNEOAUSSINLGY URINAGRIYVEENXCFROERTIMOANNOYF MPOUN2T3H9 SW HEN TWreeaetkm eonft Doisne--GrDamTPs A Per Week ADvearilayge ExUcrreitnioanry of ExpPruess2e3d9 as D iPseinr teMgirnautitoens EExffpercetsivseednesass E%ffeocftiIvneinteiassl 21 21.6 666150 19020 Nopetrrieoadtmoefnt5 fworeeks 12 1131--1142 21.6 448915 7742 Nopetrrieoadtmoefn5t wfoereks 15 2276 22 449366 7646 4363 22 214960 2397 50 2 125 19 preAcveedriangge adnadilyfoellliomwiinnagtiotnheofabPouve23t9reaftomrenpteriwodass 12 disintegrations per minute in 24 hours. emEpxloceypeet fwoarsmgiivneonr 1chganogfeDs TasPAshoinwtrnaviennoTuasblyle, i1n, tthhee M1 agnuofnactTuhriunrgsdAayreaofMeeadcihcalweCeekntefor,r otnhreMeonsudcacyesasinvde wpeereikosd.sSoufchthpreereiowdesekosf otrfeantomternetatwmeernet.alTtehrinsawteads wcoitnh- 610 SOCIAL AND LEGAL ASPECTS wdeomrke.nt above the loss of wages the longer he was off peTrpheistractaessehiilsludsitsraabteislityhoown aansuibnjdeicvtiidvueabladsiesliibneroartdeelyr to increase the size Casf N o . 3 -- A o3f7-hyiesarm-ooldnettararyinmseattnlemweanst.injured wwhhielne hsitsanadrimngwatosostrculcoksebytoa agraslbowirlyon,mcoavuisnigngtrhaiimn atocsaprinHaeroreucnediveadnda s5t-rcikme vheirstihceaal dlaacgeraaintisotnthacerossidsethoef mmiadindeled oofnhhisis ffoereetheTadh.eTlahceermataionnwwasassrtuepnanierdedbautt trhee pTlhaenrte dwisepreensnaoryo.thXe-rraiynsjuorifestheexcsekputllfowr eareslingehgtatciovne. ttuiosnionwaosf enthtiererlyighnteguatpipveer anardmremNaeiunreodlogsoic theexraemafitnear. cNaotiotnieaftomrenpat iwnasTihnedicpaatetidenotthdeirdthnaont awnaolrgkeshicismneedxit otuusrn naingdhtwahseseheandagaainmtihlde fhoellaodwaicnhge dabyu.tTwheasprneovwi apsaytimenpttomwaastics.eeEnxaamgaininatifoonurwdaasysagaafitnerntehgeatiavcecidTenhte. aTphpeliesdu.turHesiswoernelyremcoomvepdla,inant dwaasdheoscicvaesiobnriadlgefsrownetrael hreetaudrancehde two hwicohrk;waasndrewliehveend qbuyestaisopnieridn.asHteo hwahdy,nhoet gaarmve asnodmeupvpaegruebacckomEpxlaaimntisnaotifonsorweansesasgianinhnisegraitgivhet fthoer ombajenctbiveleiefvienddinhges.coIut ldseeamndedshtooultdhebephwysoirckiianng tbhuatt faoprprsoovmede froearsownorkhadandnowt adsonsoe asod.visHeed. wTahsefopramtiaelnlyt rweoturkrnededfortosevweorarkl hosiuxrsdbayust tahfetnerretphoerteadccoifdfebnetcaaunsde ocof mhpelaadinacinhge. oHf ehewaadsacsheee,n daizgzaininesst,heanfdollsoowreinngessdaoyf, thheealiunpgpewrelbl.acEkxaamndinartiigohnt reasrmul.ts Twheere lanceegraattiivoen owncaes atrgeaaitne.dHseymappptoamreanttilcyaldlyid annodt isneteennd atgoaiwnorokn;ehewweeaks lloawteirn,gatthwishicvhisittimhee hwisasconnodittiosenenwaasgauinnchfaonrgeadn.otFhoelr two weeks. It was then 24 days since the injury. The pwahtiicehnt hehadhadtakreenceihviesd vvaaccaattiioonn ipnayt.heHeinoteffreimre,d fnoor Tcohmepmlaiannts,finaanldly threetuerxnaemd intoatiwonorkwa3s0 adgaayisn anfetegrattihvies. liintjiugraytioanndagreaminastinethde actowmopraknyt,hebreecaafutesre. hHee dienmstaitnudteedd ceoarmnpinegnss,atainodn tahbeocuotmspeavneyn retifmuseesd htoisgraacntut atlhelocslsaimof. perEiaocdh ittimseeemtheisd ptahtaietnthewarseasleleyn bdeulrieinvgedthhee 3c0o-dualdy wicaolrlky aanbdle thaantd hewaasctnuoaltlycownsaindteerdedtoa.sHheavwinags pphoysst- atrpapuemaraetdic tnoeubreossiesv. eWrahl yretahseonnsd. iWd hhielentohtewpoarkti?enTthweraes bdeeinntg, tareacteodmpinanytheredpisrepseennstaartyivsehorretlmyaarfkteedr ththeaatcciit wgroouulpd hbaedggooondeiffohreandidunnuostuamlislesnwgothrko, fsitnimceehwisitwhoourkt atielnotst-atnimdehaisccfidelelnotw. Twhoisrkewrassaisntceorpmrpeatendy binytetrheestpian aRveosiednitnmgenlotstwtaims einrcaittheder atnhdan lethde teompdleolyibee'srawteelfalorest. tbiemcea.usTe hhee hpaadtieanthewaadsinajlusoryewnchoicuhragreeqduitroedmsiusstuwrionrgk Amneontthbery fcaecrttaoirn wphairctihespltaoyeddelibaerpaatertlywpaesrpeentcraotueraugne cnleaciemssaarygailnosstt ttihmee cfoomrptahney pfuorrpoinsecoomfeesgtraebaltiesrhinthgana hisThreisguclaasreeialrlunisntrgastes how management action, work ignrouwporsktangdroaurdpss fionrtelrofsetretimwei,thantdhelitmigeadtiicoanl pmraacntaicgees mdiesanbtiloitfy tlheeadiinnjgurteodexecmepssliovyeemaonndetcarreyatgeaiunn. necessary S um m ary facItnorssumthmatarhya,veI haavneegoautitvlieneindflcueerntcaeinonsoctihoe-edciosnaobmleidc seumcphlofyaecet.orTsheintdeirsfceursesiownithhasthdeealitndwiivtihduwahl'ys arnecdovheorwy fcrloemareranuoncdceursptaatniodninalg inmjuursyt , pwreicthedetheantyhoeufgfohrtt tthoatdoa anything about them. BASIC PRINCIPLES FOR PRECAUTIONARY LABELING Edward J. H ogan Vice-Chairman, Labels and Precautionary Inform ation Committee, M anufacturing Chemists' Association, Inc; ; Packaging C oordinator, Allied Chem ical C orporation, New York, N. Y. asIta isreparnesehnotnaotirveanodf athepriMvilaenguefatcotursipnegakChtoemyiostus,' Aufsascotcuiraitniogn, Crehgemaridsitns'g Aosnseociifatiiotsn acistivaitniesi.nTcohrepoMrataend n18a0tiocnoaml ptarnaidees eonrggaagneizdatiinonthceommpaonseudfacotfuremoarned thsaalne othfanch9e0mpicearls.cenTthoesfethecocmhpemaniiceasl parcocdouucnttionfocrapmacoitrye ofFtrhoemUintsitefdouSntdatiensg. in 1872, the MCA has been gcoronwcetrhneodf wthiteh cthheemmicaanly ipnrdoubsltermy.s Parcocmominpeanntyinamg othnge tchieatsieonhaiss bpereonudthoef pirtosmcootniotrnibuotfiosnafsetyto, athned rtehceorAdssoof cthheembiceaslt minanuaflal ctiunrdeursstriyn. thTishirsegaacrdh,iewvehmicehnits aismothnge omfortheenointadbulsetriyn'svpierwoceosfsetsheanindheprreondtuchtasz.ards in many thaTtheofAsistosciamtieomn'bseirnst'ereemstplionyeseasfetytogoiensclfuadrebetyhoonsde otrbajnescptiovretsinagr,e hparnodmliontge,d ainndaunsiunmgbietrs opfrowdauycst,s.buTtheI swhiathll tdhiesculasbsealitngthoisf cthimemeicoanlslytothiantstrpuhcatsethocosenchearnnedd linIgn othr euesianrgly tdhaeyms ohfowthetoindduostsroy sbaofethly.the chemicals dinistnriubmutbeedr aanndd etahceh thraaddesbeuesninlgontgheemstawbleisrheedli.mCituesd ctoommeprosuwndesre tshoatacscpuesctiofmicedinstotrutchteiounsse soefemtheed euxnisntiencg ienssdaursyt,riaalndchseumchicalws arwnienreg lliambeiltsed astowethree ussterodngoenr HOGAN 611 aodf dcsouarnsed, atlhkeali1e9s2, 7anFdedeexrtarlemCeaupsotiicsoPnso.isTonheArectwaenred, athenseumwbeerre cohfiesftlaytedirpeocitseodn toandthephlaabrmelaincgy oafctsh,oubsuet htoowldardpatchkeagheas.zarIdn omf oinsgt esctaiosens atnhdeyrelwieedresopleoliyntoend the word "POISON" to warn the user. useThoef eitxspapnrsoidounctosf btrhoeuginhdt ursetcryogannitdiontheofbtrhoeadenneeedd fsoterpsmionrethcisomdpirreechteionnsivceamlaebeinlin1g9.34Onaendofcovtheeredeatrhlye purnoifdourcmt gprroeucpasutiuonndaeryr alabseelriinegs ooff vsioxlunptraordyucatgsreoer manednttshebeStwuregeenonthGeenmeraanlufoafcttuhreerUs noitfedthSestaeteps.roTdhuecstes wagerreeemdiesnctosntsienruveedd bay vtheeryUunsietefudl SptautrepsoPseubulinctiHl etahlethy Sduercvtsicewihnich195h2adb,ecianustehespmeceifainctilmabee,lsbefeonr tdheevseeloppreod purnodgerram thweereMcaonnusfiadcetruerdingmorCe heamppisrtosp' riaAtes.sociation's groAusp,cmheumliitciaplliepdroadnudctsg,rewespmecoiraellycominpletxh,e thoergnaeneidc fboyr faurstuhrevreystecposnbdeuccatmede ebvyidethnte. TAhsissocwiaatsioenmpinhas1iz9e3d6 owfhiachprreinsuteltdedbionokdistittrliebduti"oAn tCoointsfidmeenmtiablerReexpeocurttivoens AMdaenquufaatceturLearb."elinTgh--isItsrepImorptorptaenrscueadtoed thme anCyhemcoicmal pparongierasmtsooremtobaerxkpanudpotnhosteheailrreaodwynbewgaurnn.ing label ouWr oinrdldustWrya. rNIoIt gornelaytldyidacecsetalebrlaistehded thcoemgpraonwietsh exof pthaenyd dtheveeirlopperodduicntniounmeorfabwleelln-kenwowonnecsh. emMicaanlys, cbourt pasoractoimonpsletferloymneowthecronsceegrmnse,ntbsegoafn incdhuesmtriyca, l asmawneull ofafctvuireew. Aofndp--remcaousttioimnaproyrtlaanbteloinfga--ll,thforuosmandthseopfoiinnt wdiovrikdeurasl bceogmapnantioes,oplaerrgaeteanpdrocsemssaelsl, uasnidngmcilhlieomniscaolsf Tenhteirenlyeedforfeoirgna tcoomanpyrehoefnsthiveeirpproregvraiomusoefxepdeuriceantcieosn. iinn t1h9e44saMfeChAancdolninsgideorfedchtehmeicparlosbwleams oabtviaousm. eEetairnlyg boefstitsmemtheomdbetro erxeeaccuhtiveths.e Imt awnasindetchiededshotphatustinhge achnedmitchael pforormduactitosnwaosf bay m"LeaabneslsofanindstrPurcetcioanutiloanbealrsy, Information Committee" was accordingly authorized. calTlehde, LmAePt IfoCromthmeittfeires,t astimitehaosnsinMceaybe1e7n, p1o9p44u.laTrloy isnesleucrteedainbcrlouaddedvtihewoseofwitthhe chperombilceaml,, mthedeicmal,emlebgearls, rtehsaetarcdha,tea, dmthiinsisthraastivbee, eannda sacloesntibnauciknggrouanndds. aScitnivcee icnodmumstirtyteea.ndTahdemiwnoisrtkratoofrs LoAf PhIealisth waenldl skanfeotwynproto gGruamidse tFhorroutghhe iPtsreppaurbaltiicoantioonf "WWaarrnniningg LLaabbeelsls foAr HfearrzeadrdtoousasCthheem"iLcaAlsP.I" MTahnisualm,"anisuanlo,wfrienqutheentrleyvierew stitoagne,thwisithyeaar. Fifth Revision scheduled for publica neIetd mfoigrhptrebceauatsisounmareyd ltahbaetl,inhga,vitnhge awgrrietiendg uopfonlabtehles would be simple. All one need do, you would say, is to mark a hazardous product POISON and add the idnov'solvaendd tdhoann'tst.haUt.nfortunately, the problem is more calWs hmaatyabree hthaermmfueal niinngas voafritehtey toefrmwsayuss.eAd? pCrohdeumcit swhhoiuclhd nmoaty bethlraebaetelend ythoeursamlifee assoolenlye tbhyat imngaeystkioilnl balysoabthseorpmtiaotnterthorfoudgehgreteh.e Hsokiwn. sOhafllcowuersed,isttihnegrueishis wbehtiwcheecnautshees cvyaapnoorsiso?rWgahsatwrheiaclhly aisspahy"pxioaitseosn"a?nTdhoenree ibsuttheaccduifrfaicteu.ltyThoefylamnguusatgeb.eSetxatpermesesnetds imnustetrmbes btrhiaetf sotradteinmaeryntswhoreklpmeanvouidndaecrsctiadnendt.s, Nboutt oinflysucmhusotcctuhre, fainrstinatiedrpsrheoteurl.d Innotthbee cdaseelayoefdtrwadheil-enasmomedeocnheemhuicmalss otor pthroeprdieotcatroyr cwohmopomuanyds,bewhaastkeisd otuor trreesaptonpseibrsiolintys injured by them? folAloswainrgesuplrtinocfiptlheessewaenrde madanoyptesdim. ilTahreqsueesptiroinncs,iptlhees aLrAePsIetMfoanrtuhali.n detail in and comprise Part I of the lem1. Eaancdh mchuesmt icbael tprreoadteudct inpdreivseidnutsallay diinstinthcte plrigohbt ohfaziatrsdsowonf achparroacdtuecritsticcasn.noCtonscalfueslyionbse rdergaawrdningeiththeer ifsrofmormtheed porropbyertainesaloogfiesthebasmedateurpiaolns cfhroemmicwalhiscthrucit pturorep.erMtieixstuthreast voafrytwion okrindmoorre dcehgermeeicafrlosmmathyosheavoef mthiextuinredsivisdhuoaulldcobme pboanseendts;onantyhewparronpinegrtielsaboefl tfhoer pfirnoipsheertdiepsroadnudct.shIomupldurintioets bmeayovceornlotroikbeudt.e hazardous bri2e.f,Aallccusrtaatteem, aenndts exopnreswseadrniinngsimlapblee,lseassihlyouuldndebre stood terms. an3d. Ptoretchaeuteioxnteanryt nlaebceeslisnagry.shTohueld labneguusaegde osnhloyulwdhebne pofraactipcraol,dunctotalobnaes,edbutupdoirnecttehde toiwnhaerdrenthte parvoopideartnicees ostforahgaezaradss mreasyultrienagsonfraobmly sbuechanutiscei,pahtaendd. liTngh,e aunsde othfewuasreniontgulnanbeeclesssfaorry rweloartdivselwyilhl adremvleelsosp paroddiusrcetsgarodr ffoairlulraebetlos gainved addeefqeuatatethneoirticpeuropfohseazaarsdss.urely as will gu4a.geOtno lianbdeiclsatoeftdhieffsearmenet hparzoadrudcstsanudnisfaomrmeidtyegirneelsanof uhnazdaerrdstainsdimngostthdroeusigrhablestanindarodridzeartiotno. gain greater sid5e.reTdheforfoilnlocwluisnigonsuobnjecat wmaranttienrg slhaboeull:d (ab)e nacomne hofazaprrdo--duDcAt;NG(bE) Rs!i,gnaWl AwRoNrdINdGe!s,ignaotringCAdeUgTreIeONo!f m(c)eaAsuffriersmactoivveerisntagteamcteinotnsoftohabzeardfosl;lo(wd)edproecraauvtiooindaerdy; a(ed)viIsnasbtlreu.ct(iNonOsTEin: cuansdeeorfsocomnetalcatwosranextipdoostuesreawreherree qtiuoinrsedforwthheenhathnedliwnogrdand"PsOtoIrSaOgeNo"f icsonutsaeidn.e)rsInsshtoruulcd iaslsoinfboermcaotniosinderreedlatifnogr itnoclcuhsaiorancteornistitchse olfabtehl.e Tchonis tainer as well as those of its contents.* sku6l.lTahned icnrcolsussbioonnesofonthae lwaboerld sh"PouOlIdSObeN"limanitdedthtoe those cases where the product is a poison according 612 SOCIAL AND LEGAL ASPECTS ptoresacrdibeefidnitbey tloaxwi.ciWty hsetnanudsaerdd, othriswlheegreendsuschhouulsde bies huPnadrrtesdIIilalnudstrIaItIivoef tlhaebeLlsAPsuIcMh aansuatlhceonotnaien ssheovwernal. innotadtadkietiotnhe toplatchee ootthtehre lwaboerdl swDarAnNinGgsERaIn,dWsAhoRuNld aTmhopslees iinnclPuadretd 1a1reagreenefroarllyinfdoursttrhioalse cphreomdiuccatlss.mEoxst tIhNeGr!e,laatnivde CdeAgUreTeIOofNh!,azwarhdic.fh are designed to show iambprooratdanrtancgoemmoferhcaizaallryd,s.anTdh,easlaabewlshionleP, athrteyIIItakcoevienr sh7o,ulAd nnoontdebsecriupsteivde acsodtehedeosinglnyatiidoenntoifrictartaidoen noafmea sthecetiomnajworaistyadodfedpefsotlilcoidweisngsotlhde ipnaslsaarggee ovfotlhuemeF.edTehraisl hshaozwarnd,outshechleambeilcals.hoIufldthecleacrolmy psletatete ntahmee tyipse nootf ITnhseectliactidteer, rFeuqnugiriecsidea,deaqnudateRowdaernntiicnigdelaAbeclts ifnor19th4i7s. ch8e.mWicaalr--niengg ,st"aCteomrreonstisveshAocuildd",b"eLgeraodupCeodmtpooguenthde"r. ihmavpeortthaentingfroorumpaloafpcphroemvailcaolsf, tahnedUtnhietedMSCtAateslabDeels pinrinatepdroimn ineaesnitlylolecgaitbiolen toynpethwehilcahbeils ainndcoshnotrualsdt bbye pInatretmrperenttatoiofnA1g8r,icRueltvuisreionan1d. are consistent with its tteyrpoognratphhey,lablaeyl.ouTt,heorlacboellorshwouitlhd obethearffipxerdintfeirdmlmy atto exHpeocwteds,utchceessLfuAlPIisptrhinecipLlAesPIhaPvreogthraemb?roAasd msuapypobret anIdn inacacocrodnasnpciecuwouisthpltahcee opnrintchieplceosntjauisnter.stated the o90f MpeCrA cemnetmboefrst,hewhUo,Saspsrotadteudctioenarlioefr, irnedpurestsreinatl "uDsuAalNGwEaRrn!i"n,g"WlaAbeRl NiInNclGud"e,so:r ("aC) AaU"TsIigOnNal""--wtoorgdi--ve achnedmiocaults. oIfn thfaect,Ascshoecmiaitcioanl , mfaunlluyfacstuuprperosr,tedbotthhesine aa gsteanteemralenitndoifcahtiaoznardof otrhehaszeavredrsi--tysuocfh haaszar"dV;ap(ob)r panridnciisplessu.ppTohretedveeryxerftasctathpaetrsusuacsihvea foprrcoegraumponextishtes AExbtsroermbeedly THharozaurgdhouSsk",in"";Ca(uc)sepsreBcuaruntsio,"naoryr "mReaapsuidrelys mlabaenluinfagctuTrhere lwathtoer mknigowhts oththaet,rwsihsoeuldneghleecbt e pcraolpleedr p * --hesautchanads o"pDeon nfoltamber,e"atohre "vAapvooird," c"oKnetaepct awwaityh fsrokimn itnoadceoquuratteblyecaluasbeeleodf pcrlaoidmuecdts, inthjueryopbpyosionnge coofunhseisl ainndcaseeyeosf";acacnidden(td,)a, s w"Ihnerecasaepopfrocporniatatec,t iimnmstreudcitaitoenlys swimouilldar scuormelpyetictiuvee pthroeduwctasr.ning statement used on afltuteshntisoknin."or eyes for 15 minutes; for eyes get medical CoWmimthiitnteemionnth19s44a,fteitrs tchheaiormrgaannizwaatisonasokfedthteo LseArvPeI maUysirnegad:these or sim ilar statem ents, a typical label saesquaednvtilsyorbetcoamtehetheStfaitrest ooff sCevaelirfaolrnstiaat,eswtohicrehgusluabte DANGER! HAZAARNDILOIUNSE LIQUID AND VAPOR RAPIDLY ABSORBED THROUGH BtheesidpesrecCaaultiifoonrnariay, tlhabeeleinnsguinogf yheaazrasrdhoauvse csheeemn icsaimls. ilar regulations or laws adopted by Connecticut, SKIN Oregon, Hawaii, Illinois, Texas, New Jersey, New' DAovonidotbgreeatthiningeyevsa, poonr. skin, on clothing. Yupoorkn SthtaeteMaCnAd NpreiwnciYploersk. City. All have been based IUnsecoansely owf itchonatdaecqt,uaitme mveednitailtaetliyon.remove all contaminated clothing, including shoes, and InsReecftiecriednec,e Fhuansgicaildreea,dyandbeeRnodmenatdiecidteo Athcte, Faneddertaol the lact that LAPI labels comply with the regula lfeluassht 1s5kinmionruteeyse;sgwetithmepdliecnatly aottfenwtaiotenr. fWorasaht clothing before re-use. tioAnst misesueteidngpsuorfsuthaentIntoterint.ational Labor Organization, POISON hareyld laibnelGinegnesvyas,teSmwiwtzaesrlaenndd, otrhseed MaCndA'smpurcehcauoftioints content adopted for ultimate use by ILO on a world \ t*iAonulhhoars's Naovateil:abTlhee Matanitusfacotfufircien,g 1C8h2e5miCstos'nAnesscoticciuat wiAde cboasmism. ittee of the International Association of Avenue, N.W., Washington 9, D.C., at nominal cost, a Governmental Labor Officials, which consists of U.S. ! sthereiepsroopferitnidesivaidnudalessCehnetimalicianlfoSramfeattyionDafotar sSahfeeehtsanodn aisntrdatoCrsa,nahdaisandesvtaetleo,pepdroavin"cSiuagl,geastnedd DferdaefrtalfoardmUnini alinndg Raencdomusmeenodf e7d9Pcrhaecmticiceaslso,nMthaenuuasles aonndShtaannddalirndgs ffoorrmUsReu, leHsananddlinRg,egaunldatioSntosrargeelatoinf gCtoontathineerLsabHeolilndg goefnsepreaclifipcreccoanutatiionnesrs,foarndhaanndloinugtlinaendofstroercaogme moefndceerd iEnmgplSouybesetsa.n"ceTs hHisardmrfauftl taodhtehreesSatfoetyLAanPdI Hpreianlctihpleosf tTahinesecladsasteas wofillcosenrtaveinearssexinceltlheentMgCuiAdesLAinPIthMe adneuvaell. ianndNewwasJetrhseeyfoanudndNateiownYfoorrk tShteatecuarnrdenCt itrye.gulations aonpdmesntotraogfeasptpaltiecmabelnets.phrases for container handling indInusttrhyispahritgichulylarrleyg,ualraetedsubejreac--tewd hteonmaalnl yorfesutsr,ictainvde {Author's Note: The word "POISON" has been used ilcaawlsinadnudstrreyguthlaattiointss--aditeqisuattoe tlhabeelcirnegdiptraocftitchees cbhegeman iinlldidsecfriinmeidn.atFeolyr ilnabtehleinpgasptu, rapnodseists tmheeaMniCngA hMasabneueanl alastiaonvoolfunrteacryentpryoegarrasmhaasndbethenat itnhesulpabpeolritngoflegthise irnegcoesgtnioizne,s ipnohiasloantiinogns, abnyd tharbeseorpmtoiodnes thorfouegnhtrys--kivni--z., industry's principles rather than controverting them. Further evidence of the LAPI Committee's in tbouxticliitmy ithsasusbeeeonf dtheemownostrrdatetod, theoitsheercabsyes hwuhmearne tehxe sfltuaennticaellyis tihdeenftaicctalthawtitdhefitnhiatitonosffoirts"PmOaISnOuaNl" wsuebre pdeerfiineendceliomritlsa.boratory animals tests, to exceed certain swercittitceinde inAtcot tahned rheagvuelatailosnos buenendersubthsetituFteedderianl tIhne KLEIN 613 Ifonrtmeres.tratdeefCinoimtiomnerocfe "CColmasms iBss.ioPnoiRsoengsu."latAiognasin,foLr AthPeI hoafsthbeeewn oridnst"rfulmamemntaabl lei"n boybtIaCinCingandtheothaecrcepptuabnlcice a"ginefnlcaimesmaabsle.l"essItslikreelpyutatotionbe hamsisuexntdeenrdsteododsothfaanr Mthaant ufianctu1r9e5r3s, twhehicAhssiosciMatiCoAn'soBf riBtirsihtishcouCnhteermpiacratl, sthenetLrAePpIrepserongtartaivmesantdo stuhbisseqcuoeunntltyryadsoolpetleyd toonestpuadry allTelhinisg pitr.ogram is receiving additional impetus from oouthserintratdheeirasscoocoiapteiroantsio, nw. hAicsh halarveeadbyeeinndmicoasttedg,entehre cLhAemPIicaolsb.jeWctihviele istheprpinricnicpiapllleys aarime egdeneartalliyndaucscterpiatl adbelteail toforalldigffreoruepnst, stehgemirenatsp.plAicatcioonmmmitatyee voarfy thine Cprheepmariceadl aSpmeocidaelltielsawMfoanrutfhaectulraebreslinAgssoofcihaotiuosnehhoalds padroddituicotns. toDisrmecatlilonhsoufsoerhouslde paraeckuagsueasllayndanmiamy pcoorntvaenyt pinrfeocramutaitoinoanryfosrtatpemroepnetrs. uSsiemiwlahrliyc,h thseupAplmemereicnatsn Pthee ctraoulteiuomnarIynsltaitbuetles rfeocrenptleytropluebulmishepdroadumctasnuaasl doifstpinrcet fprroinmcippleetsr.ochemicals. Both associations support I-API anTdheunciofmormmonlaabimelinofg alolfthtehsee ghroauzaprsdoisusthesuabdsetqanucaetes wfreheichflotwheyofprcoodmumcee.rcUe naifnodrmiimtypoirstaenstsenintialedfuocratitnhge pinegosp. lTe hteo puunbdleicrsmtanudst btheelesdigntoifirceacnocgeniozfe ltahbaetl cwheamrni qcaulirperocdaurcetsinmahya,nodnlinogc,cajsuiostn, abse ehxapzearrideonucse atnedachrees utosolsthaatndcarwe itihn ehleacntdrilcinalg aisndnecmeesscahraynicwalithdeevdicgeesd. cUhnelmikiecaltshe wlailtltera,lwwahyicsh rseeqlduoirme csaormrye wparrencinagutiloanbaelrsy, lmabineelidngb,ybevciasuusael tihnespirecptrioonp.erties can seldom be deter preIncauctoinocnlaursyionla,bIelisnhgouplrdoglirkaem tobaesemdphuapsoizne tthheatprainny cciipalteiosnsectofuolrdth nboyt tbhee McoannsiudfearcetdurienxgpeCrhimemenistat'ls. ATshsoe ctiomnec-epprtovoennwahnicdh ascuccehptaedpriongrsaimmilwaarspbraosgerdamhsasinbeteern ntaaktieonnaolluyt. iWnsiutrhanscuechona tphreogfruatmureyoouf yhoavuer pnrootduocntlsy, fbuuntdaymouenthaalveoblpirgoavtiiodnedtoawnaerncesosfartyheahdejuanltcht hianzarthdes pinrvoodluvcetds. in the use of either new or established I thank you! THE CARDIAC CASE IN WORKMEN'S COMPENSATION I r v in K l e in , M.D. M edical D irector, W orkm en's C om pensation B oard, State of New York thiIrtteiesntmhy Ignrteeartnaptlieoansaulre Ctoongbreesasbleonto Oacdcdurpesastiotnhaisl nHoeanlathti.oIntalisbosiugnndifairciaenst, tahnadt tcoogmemthoenr wperobhalevmessokungohwt r3e0myeedaierss. iInt disiffaeprepnatrecnotunthtraiet sthoifs tihse thweoroldnlyforsoouvnedr mofetahdodditiboynawl hsicighniwficeanccaen tshoalvte wtheesaereprothbulesmasb. leIt tios smeat ttearsgomoady ebxeamdipspleoseodf otfh.e way in which other casTehiisn awfoterrknmoeonn's wcoemapreensattoionc.onTsoidemr ertehley cdaisrmdiiascs itat lewnitthantdhe inwteavnetioonf othfethhisandorgiasniuznawtioonr.thyA osfearthche ianntdo itmhepocratuansets. Tanhdereresiusltsa icnontthinisuianrgeaanisd ngecroewssianryg iinntetrheestcoiunrsethoef ecmarpdliooyvmasecnutl.aRr eecpenistolydegsredaut rainttgentaionnd hcaassesbweehnichpahiadvetocomthee beinfocrreeatshinegwnourkmmbeenr's ocfomthpeesne sNaetiwonYobrokarSdtastefoforr ethvealuyaetairosn19a4n7dtoad19ju57dicthateiofnig. urIens hthaevefirrsitsesnix fmroomnth1s6o7f c1o96m0puenpsatoted150cacsaessestowe5re45c.loFseodr wwiitthhdoruatwaawl aorfdcflaoirmm, aannyd rfeaailsuornes t(ofamilaukree otoutparopsercoupteer, cbaeseen atfhteer ctoriraoln).arTyhaertmeroiesst frreesquulteinngt iinnvoplvoestmocecnltushivaes anIgtinias, nfaoitlunreec, epsusalsrey iarrtegthuilsarittiimese, atondreivnifeawrctitohne. var iiosuist snkeicllesssianrvyoltvoedreviniewthethediangeneodstifcorpprorcoepdeurrehsi,stnooryr and record keeping. We can safely assume that the tthraeisnee. dThpehreysriceimanainiss, tfhuelrleyforaew, aornelyotfhethceonsnideeedratifoonr owfortkheloraedlatainodnshthipe opfrotpheer praethhaobloilgitiactiopnrocoefssthtoe pthae itnientth.eItclisossuurgegeosftead cthoarotntahrey evxeascsetlmaencdhanthices riensvuolltvaendt mmyuostcarbdeiafluritnhfearrctcioonncedaered nthoatt ftuhlely sculnerdoetrisctopordocesIst pbleagyisnsafaliarrlgyeeapralryt iinn atdhueltolcicfeurarenndcethiisn, iunndduosutrbyt.edly, is Iht irheads fboerenhitsheabpilhiitlioessopahloyngthawtiththealwl oorfkinhgis mdaisn ainbciluimtiebse,nwt hueptohner thmeanpihfeyssticoiarn htioddbeen.thIet ifsirstthetorefroerce oogfnitzheis thasis winell.inIdtusatrpyp.eaOrsthetors msheouthldat bneo codgenfeiznasenst caanny bdeegsereteupofonscltehreostihsotuhgehtcltihnaictailn eandgivreensucltasewwouitlhd hthaivse tyopcecuorrfedreainsonaninyg elveeandts. nWowe hmeruesst, rseicnocgenigzeenethraalt itzoatbioenpsrehpaavreed ltiottlteakevaaluneatitnitudtheiswhairceha.apIpt eairss breeast seoanchablceasteo oonrdiintsaryowannalmyseirsitsa.ndRebceogrneiatdioyn tothraetviewwe dporecnloutdheauvse afrofmull derxapwlainngatiaoncoantcltuhsiisonti.me should not proIct esiss iims ptohretandtomtoinaknetep faicntormiwndhenthatthethecarldegiaacl cbaesceominesinidnuvsotlrvyedis idniscauscsaesde. Ttoooaofpteonintthebepyhoynsdicihains mofedanicaaldvsopchaetree.inAtthethpartocpeoeidnitnghsefoarttwaihnischthhee isstantuost trained, for which he is obviously ill prepared and 988 MAXIMUM ALLOWABLE CONCENTRATIONS dinailystawtionrgk wMitAhoCuteiinthteerrv)alspe(rwfohricmhinagre pnhoytscicoanlsidweorerdk w(ohric1h0:1r;eqluoiwreesr avvoeluramgee cmoiunldutebelucnognsvidoeluremdeoonfly12fo:1r etvnatsireelvyidesnetdetnhtaatrya wwoorrkk)m. anFroambsortbhsis3.4caglcu(loartio2.n8 gi)t o85f0trmicghl(o7r0e0thmylge)neofintricehiglohrtacheotiucrsa,cidmoadnidfiesintiot 1in89to7 mgIt(1is41d2ifmficgu)ltoftotrsicayhlohroewthagnreoal.t is the pharmacologic defufeecttooftdhaeilyfacatdmthiantistirtatdiooens onfo3t gococfutrricinhlosruecthhydleonsees, iisntemreeddicpalerpraccatsiece.inIn tchaesespasotfyeaanrsgi1naml pweacstoardismionr nBeeufroarleghiaandn,.throigweemveinr,i,wefocuarn tsiumpepsosea adhayypnmoatixcimefufemc.t emsepdeicairayllypriof dwuecttainkethinetomectoanbsoidliesmratioofntrtihcahtlotrheethyinletenre icshlochrelothryallhenyedractoerreTsphoendass, cearctcaoinrdeidngdatoilythdeosAemoefrictarni MtheACc,utrore4nt3 ghyopfnochtiocradlhoysedraiste 1I-2t isg,waenlldkniot wins tahlsaot kvneroywnrartehaatndchirsonsiicmiilnatroxtoicacthioronniwc itihntocxhilcoartailoniswnitoht tricIthloisreatlhsyolepnoessible to see to the effect of trichlor eetthhyanleonle, wanhdic,hinisouthr eoppirniniocnip, aitl ims pertiamboalriitley orefsptroicnhsilbolre fthoartthpehasrymmacpotolomgsicoflitienrtaotxuirceatdioone.s Onowtinogftetno mtheentfiaocnt Nthaisrcosusibsstiasncaet,tawineecdanbycotmhipsarseubisttawnicthe tarfitberroma edthoasenool.f f3o.5r-m5.s6 1g9ign oaf mtriacnhlworeeitghhainnogl 7d0aiklyg. In our case there thaIt ththinekAtmhaetrictahneseMAcoCnsiisderraatthioenrstoroesuhlitghi.n Ifthiet fwaacst ctoreadteecdlafrreomthaetxpaenriimmaelnstsawreithnoatnismuiatlasb, liet iisn nterciceshslaorry eluthnyglsenaendcahseasvebeecnatuisreelythedyiffhearvene tgwreaayts doefsamtuertaatbioolnizsinbgy triTchhleoredtohsyelenreeq. uired by Swedish authors, 50 mg of otrniclyhlotoractheeticSoavciiedt MinACur--inteh,atcoisr,re9sppopnmds atbhoeourtet5i0cally ereFdromonlyourtripcrhelvoiroaucsetiecxpaecriidmeinnts,smwahlelerre pweercecnotnasgide, o16f tpreicrhlcoernetthwylaesnefouinndaitrha(tupintolowabeoructon40c0entriagtiopnesr alictiedr--inthamtg itso, t7r5ichploprmet)hytlhenee riantiofig oifn tIricIholofraaciertiics ainbgoucto1n:c2e.nTtrhaitsiornatioof wtraischdleocrreetahsyilnegnew. itShevtehrealinocbresaesr voautriornescefnrot mexpprearcimticeentsberaersuwltistnetshsattothtehisratfiaoct.isFrtohme othreatticiatlliys n1o.1t p(oSsosuibleek-tVolagcivhoevm4,orBeaarctocnuiriaetke).dirIectthioinnks pforarcptircaaclticwe,ordkueantdo tthheusgrweaet cdainfficcuolnticelsudoeccuthrraitngthiins ratOion ltihese wbaisthisinofthleitermaetunrteiondeadta vtahluaets aITgreaotr p1a2rt. oaflowngo-rtkimineg wpoerokpalet 5h0avmeg ohrea1l0th0 mdgistoufrbtraincchelosracaeftteicr sapciodn dinw iutrhi n1e00p etro-`l2i0te0r f we ig osfeet ritchhalot reitth ywloenueld incorarier Tofhitsriccholnocreenthtraantioolnininuariinrecorresponds with 100-200 fig vaFluoers tihnethpeurmpoosset iomfposorltvainntginthdeustqruiaelstpioonisoonfs MtheArCe omuagdhet otbosebrveatiaovnasilaibnlepraactgicreea. tItnuismablesor onefcecsasraerfyulltyo imnveteasbtioglaistem,,inanldabeolriamtoinryatieoxnpeorfimtehnetsse, sthuebstaabnscoersp.tiFoonr, amcetudaicllayl tahbisnokribnegd idtosies. aEcxceppetraimbleentsto wciothnsidaenrimtahles daruecesduictahbelmeicoanllysufbosrtanthcees.orientation of newly intro SCIENTIFIC BASIS FOR THE ESTABLISHMENT OF TOLERABLE LIMITS ADOPTED IN THE UNITED STATES FOR THE PRINCIPAL INDUSTRIAL TOXINS Ch a r l e s R. W il l ia m s , P h .D. Assistant Vice President, Liberty M utual Insurance Company, Boston, Massachusetts limInits)theforUinnihteadlatSiotantesa,rehydgeievnelicopestdanfdoarrdtshe(tpoluerrpaobslee etonxciec tmo aatecrcieaplst.abTlehuvsaluwees ffionrd esxupcohsutreersmstoaspo"tMenatixail osufrepsrotvoidtionxgicgmuiadteesriatols bine uinsdeudstfroyr. cTohnetsreollgiunigdeesxpaore mthuembrAoalldoewstabulesagCe;on"cMenatxraimtioanl ,"AcwcehpictahblceerCtaoinnclyenhtraas dmeapteenridaelsntthoenrethaerebalseicveplshiolofsoepxhpyostuhraet wfohricmh ocstansucbhe Stiotann,"darwdhsichAsshoasciabtieoenn Zu3ti7lizeCdombmy itttheee A(1m);eriacnadn ttioolnersatteod thwiisthpohuitloasdovpehryseaereffetcht.osTehwe hpicrihncairpealapexpclieepd "ATmherreischaonld CLonimfeirtencVealuoefs," GwovhiecrhnmiesntaulsedIndbuystrtihael tkonocwanrcionfotgheenipcroacnedssesseonfsitciazricnignomgeantiecriitayls.anSdoselintstliteizais iHmypgliiecnaitsitosn--(2)n.aAmlellyo,f tthheaste ttheersmes vhaaluveesthaeresaamlleowbaabsliec ktinoonwnthactartchineogteenndicenacnydissetnositciozinnsgidemr attehraitalslevsehlosulodf ofirneaclcinepetabbelteweoernthtaotxitchearnedisnoanltiomxiict.wAhsicah mdeantotetersoaf btheenk,epist taos dcelvoeseloptoinzfeorromaatsiopnoswsihbilceh. Tcahne pprorovbidleema, cfaocntn, otthaetiounses.rs Tofhethepsreobtelermms irsareolnyeacocfepstemthaentiimcsp.lieInd vwahliidch bcaasnisbfeortoleesrtaatbeldishiningthelevinedlsusotfriatloxeincvimroantmereianlts. A19n4n9uathl e CCoonmgrmesistteoenonOcCchuepmatiicoanlalAgHenetasltaht t(hUeni9tethd TERMINOLOGY Swtaastesm) urcehcommmoreenddeedsctrhipattivteheoftetrhme "aHctyugailenuictilGizuatidioen" In order to avoid confusion it must be pointed out that there are differences in terminology with refer IonfduthsetrianlumHbyegrsie.neInASsseopcteiamtiboner, be1g95a5n, pthuebliAshminegricaitns WILLIAMS 989 m"HenydgieednicMGaxuiimdeumSerAietsm" osupshinegric thCe ontecremntra"tiRoencom(8 eaxbclyesswoofuldthepraocdcuecpetabinlejurcyo.ncWenhternatiothne plreovbel h"Houyrgsi)e."nicInSta1n9d5a6rdsSmfoyrthDa(i3l)y pInrohpaolasteidon.t"heForusesomoef time the writer (4) has been urging the general accept htiaosnableecnhaensgteabloisrheddiscoonmftohret, biatsiiss olfogaicaful ntco assume that exposure to concentrations not a"nHcyegieonfic thGeuidceo,n"cespint ceofthe"sHeygtieernmics eSxtapnredsasrdm" ucohr gwroeualtdlyneoxtcpeeroddinugcethme aatcecrieapltlaybilnejucroinocuesnterfafeticotsn. Hence it is important to understand the cri mofosruecahcccurirtaetreilay itnhethaectuoaclcuppuartpioonsael ohfetahlteh afpieplldic. ation atebrliea cuopnocnentwrahtiicohn ahnays bsuecehn emsataxbilmisahleda.ccept ORGANIZATIONS ceTnthraotuiognh itshetopumrpinoisme izoef thheealatchcehpatzaabrldes,coints immediate use is for guidance in establishing guIidnestheis Ucnaritreiedd Sotantesbythegroeustpasbliosfhmceonmt poeftenhtygiinendiic viduals operating within existing organizations and eanbgleineceornicnegntpraroticoendsuroefs ttooxipcreovrenntoxoibojuesctimona terials from being present in the air of work iuctailnizinSgtanadvaaridlasbleAstseocchiantiicoanl, inaforpmriavtaioten. oTrghaeniAzamtioern apnlaaclyess.es Cwoimthparthisoosne coofnctehnetrartieosnusltsindoitcataeisr acceptable conditions or otherwise the need, rdeepvreelsoepnmtienngt Aofmsetraicnadnardinsduinstrtyh,e hoacscubpeaentionspaol nhsoerailnthg eSxatmenptl,inganadnd uarngaelnycsyis sohfoucldontbreolcamrreieadsuroeust. Tfiehledsesin"cAem1e9ri4c1a,n chSiteafnlydarthdrso"uginhcluitdse 7.t3h7e Csocmopmeitatened. purpose as well as general physical-chemical and bmyethcoomd pwehteicnht pweirllsopnrnoevlideusaingrelaianblaeccmeepatsaubrlee of exposure. taonxdicspamroppleirntgiesa,n"dMaanxailmytai]caAl cmceeptthaobdles Canodncerenfterraetniocne,s" coAncirenatnraatliyosness ionf csouncjhuncattimonospwhiethricaccceopnttaabmle inants as are encountered in industrial opera Sliisnhceed,thaenidr stthaert C1o9msmucithteestainsdcaordnstinhuaivneg btoeenbepuebx atiomnseasnesrvoef adsiaagnmoseiassuorfe oocfcuepxaptoiosunrael--dnisoetasaes. Ctreommemlyitteaectivoepeirnatetsheisfiseeltd. fTorhthe binasitsheoninwtrhoidcuhcttohriys Dofiaaglnlofsaecstosrhsouinldclubdeinbgasreedsuolnts aofcocnlisniidcearlataionnd sfotalltoewmse:nt provided with all of their standards, as pmheyasnicsalofexaasmseinssaitnigonaamsowuenltls asofofmaiartearniaallysseisn, the body, and a knowledge of toxicologic "CTohneceMntreaatnioinng" o(f1 )M axim al A cceptable effIencts tohfe thaeppmliactaetriioanls ionf qutheestiosnta.ndards, it should be kept in mind that: levIetlsisofgecnoenrcalelnytrarteicoongnoizfedatmthoastphtehreicre coarne (1) Tsthaendaarcdcsepotafbgleoocdonpcraecnttircaet.ions serve as wtaimthionaunt tskntoowwnhicilhl aeffpeecrtssonormdaiyscboemfeoxrpt.oseInd (2) Tsihgenyansdervoepearsatieonngisnheoeurilndgaigmuidaetsm. aDine I vuinecwonotafmtihneateidmpariarctiincambiolistty inodfusmtraiianltaeinnvinirg taacicneipntgablaellmacxoinmcuenmtr.ations below the aobnlmeenctosn, cietntirsatinoencsessoafryattmo oespsthaebrliicsh caocnctaempt (3) Tbyheycosmhopueltdenbt einadpipvliideudalasndwiinthterpareftueldl Tinhaenstes ceonncoceunnttrearteiodnsin inindthuesmtrisaellveospedraotionnost. utinodnesrostfanthdeinignfoorfmtahteionbafsriosmanwdhilcihmitthae rreepprreesseenntt tahesccaolenceonftrarteiloantisveof tocxoinctiatym:intahnetys (4) Isttanisdaarddvihsaesd bteheant dtehveesleopsetda.ndards are ebxeploewrienwcheidchby1a1nyefbfeucttshyapreersuunscliekpetliybletoindbie cinodnusisdtreiraeld hytogiebnee agnudidaesre tnoowtairndtengdoeodd vidTuhaelss.e concentrations are usually based upon data obtained by one or more of the (5) Tasheleglaelverlesquairreemaepnptlsi.cable only to ex posure to a single substance. In the fol(l1o)wLinagboprraotocerydutreesst:s on animals mcaasey obfe einxcproesausreed toor mdeicxrteuarseesd,, tahnedefcfoenct ((32)) ELanbvoirroantomryentteasltsaunsdingmehduimcaaln isnuvbejsetcigtsa striotulsatisohno.uld be based on the specific A ctoiomnms oinn pfelaantutsre of these procedures is that the experimental exposure shall cor triTalheHyAgmieenriisctsanbeCgoannfeirtesnwceorokf iGn otvheernsmtaenndtaarldsIndfiuelsd rsehsopuolnddb.etotakthene innotormcaolnswidoerrkatiopnattaelsron.inTthhies iwnit1h94v7a.luTehse, ywphuicbhlisthheaynncuaalllly"tharleissht oolfd thliemmitsa.t"erTiahlse, atipopnlicvaatliuoens. of maximal acceptable concentra Three criteria have governed the establish vcoalmuemsitwteheichof aqreuagliifvieend reexppreerstesntinthetheconoccecnuspuastioofnaal health field. They are reviewed and brought up to me(1n)t Oofrgtahneisce ocronoctehnetrrattiisosnuse: changes (2) Functional reactions which have no d1a95te9 e(2a)chcoynetaarinsThvealumesosftorrec1e6n9t gpasuebslisahnedd vlaisptordsa:te7d1 dbiustcecrnauibslee iumnptoaiwrmaredntse,ffescutcshonas hiena-cltoh- atoxliicstduosfts,21fumsoe-sc,alalnedd mteinsttsa;tiv1e1 mvainlueersa.l Tduhsets;baansidc ordinations and increased proneness to (3) Dacicscidoemnftsort or adverse sensory effects pphreilcoesdoipnhgyitsoflisthtiinsggorfouvpaluises:set forth in paragraphs haIvne tbheoesne ecsatsaebslisinhedwhoinchthtehebacsoisncoefntorragtiaonnics changes, it is logical to assume that repeated "Threshold Limit Values for 1959" (2) Threshold limits should be used as guides exposure to concentrations significantly in in the control of health hazards and should 990 MAXIMUM ALLOWABLE CONCENTRATIONS annodt dbaengreergoaurdsecdonacsenftirnaetiolnins.esThbeeytwreeepnresseanfet cnoenardliytioanlls wuonrkdeerrs mwahyichbe irtepiesatbeedlliyeveexdpotsheadt, dvaaylueasftleisrteddayr,efewr itthoouttimaedvweresieghteefdfecat.verTahgee caomnocuennttrabtiyonws hifcohr athenseormfigalurewsormk-adyayb.e Tehxe hceeeadltehd dfoerpenshdosrtuppoenriodas nwuimthboeurt oifnjufaryctotros swuhchethears vtehrey hniagthureconocfentthraetioncosnteavmeninafnotr, swhhoerttherpetrhieodesffepctrsodaurececuamcuultaetivpe,oisthoeninfrge, qanudencthyewdiuthratwiohnichofhsiugchh cpoenricoednstr.aAtiollnms uosctcubre, dtaekceisnioninatos tocownshidetehreartioan hainzardaroruivsinsgituaattiona etoxisttsh.e Spaepcpilailcactioonnsidoefrattihoenseshvoaulludesbeingivthene ebvealausastoicoinateodf wthieth heexapltohsuhreazatordscowmhbicinhatimoanys ofTthwroesohroldmolirme itssubasrteanbcaesse.d on the best avail afrbolme inefxopremriamtieonntalfrosmtudiinesd,usatrnida,l ewxhpeenrienpcoes, sviablluee,sfraorme baasceodmobninavtairoinouosfctrhiteeritwa oo.fTthoexsiec esfhfoeuctlsd onrotobne musaerdkeads adicsocmommfoonrt;detnhoums,intahteoyr othfetosxoilceityc,rinteorriosnhoiunldptrhoevyinbge ocrondsiisdperroevdinags diaTghneosseis liomfitssusapreecteindteoncdceudpaftoiornaulsediisneastehse. feimelpdloyoefd inbdyusptreiraslonhsygtireanineedanidn sthhoisuldfielbde. Tfichaetyionarefornoutsei,ntienndtehde feovraluusaet,ioonr ofrorcomnotrdoil onfuiscaonmcems.unity air pollution or air-pollution CoTmhmesiettevealounes TahreresrehvoiledweLdimaintsnufaolrlychbayngtehse, rbeevciosmioenss, aovrailaadbdleit.ioTnsh easCfoumrtmh eitrteienfowremlcaotmioens tthhee sluisgtgeasntidon aolsfosucbosmtamnceensts,torebfeereandcdeesd, otor reports of experience with these materials. IndInustaridadlitiHoyngietone thAessseocitawtioonghroaus,pss,incthee 19A5m5,erbiceaenn phauvbelishbienegn thpeubHliysghieednicfoGrui9d7e Sseurbiessta.nTceos.daItne gmuiadneys orefspSemctysththiins hseisriersepiosrtsimtoilathretoA.tIh.He.Are.cionmAmpenridlat1i9o5n6s. tIhneforrmecaotimonmeinsdpedrovmidaexdimfourmeaacthmomspatheerriiacl rceolantcievnetrtao tthioenss;hsoervt-eerxitpyosoufrethteolheraaznacrde;s (abtmotohsphheearlitch caonndcefnitrrea); tcihoenms iciaml mperodpiaetretliyes.haInzaraddoduistiotno, ulinfed;erphthyesichaeladainndg ogfive"nIndasusttoriarlecHoyggniietinoen,Preavcatliucea,t"ionbrioeff estxapteomsuernests aanrde rheecaodminmgen"dSepdecifcicontPrroolcepdruorcees,d"urebsr.iefAdlseos,criupntidoenrs tahree gmivedenicaolf pfrirosctedauidr,esp. roFpihnyalllayc,tica mliesatsuorefs,reafnerdenscpeesciaisl gthiveehn.eaIdtinigs oaflso"RseicgonmifimcaenntdetdhaMt aixnimeuacmh Actamseo,spuhnedreicr oCfonthceenrtreactoiomnm,"enadasttiaotne.mTenhtisisapmparodaechas retopretsheentbs asbiys fparrobltehme omfoessttabdleissihrianbglehywgaieynicofstadnedaalrindgs. Mwietrhe ltishtes iomf pnourmtabnetrsthleaatveallmuacvhailtaoblbee idnefsoirrmeda.tiIotnisreelxattrievme eltyo the establishment of the standard be included with it. BASES FOR THE ESTABLISHMENT OF HYGIENIC GUIDES inTthhee eUstnaibtelidshSmtaetnest oisf nbuasmedbeprsrimfoarri"ltyoloernabtwleolikminitdss" opferiiennfcoerm. aTthioen;scaiennimtifaicl erexspeearricmhenwtshicahndprhoudumcaens tehxe sbiatiseics, dreasteaaricsh claarbroieradtoorinesb, yanpdrigvoavteerninmdeunsttaryl ,aguennicvieesr. TmhaenyreUsunlittsedofStsautecsh teincvhensitciaglataionnds sacrieentpifuicblijsohuerdnalisn niqInuesoomfe acpaspelsy,inpgartiacnuallaorglyy nwewithchoetmheicralsw, etlhl-ekntoewchn cuhnetmil icvaallliyd sdiamtailahravmeatbeereianlsachcausmsuolmateetdimes been used utiTlihzee aclolmamviatitleaebsleorpuobrlgiashneizdatiaonnds ruenfpeurrbeldishtoedabdoavtae ilnevealsrriwvihnigchatwitlhleiprrojvuiddgemeantbsasaiss tfoor thseafekgiunadrsdinogf employee health. Animal Experiments phTyshioelogtiecchrnesiqpounesesofin eavnaimluaaltsingas atoxmiceoalnosgicof parned adgicetnitnsg, oproossthibelre enefvfiercotsnmoefntatolxciocndmitaiotenrsiaolsn, mphanysihcaasl lfoienldg. bIneeJnspaiteroouftitnheis,tohoolwienvetrh,ethoecrceuphaatsionbaelenheliatlttlhe iantvteemstipgtatmivaedetetcohnpirqouveisdeina sintadnudsatrrdiaizledtoxaipcporloogayc.h Itno mthaenyeffreecstpsecotfs athitosxiisc fmorattuenriaatle,onfora inbiodleoagliicngsywsteitmh cfiosnhseiddercarbitleeriafl.exUibsiuliatlylyisearrelqyuitreesdts inwiallppilnydinicgateestathbe cleotuhrasle doofsesfuarnthderthestuedfyfe.ctsThoen dmifafgenreitnutdeorgoafnsacwuitlel iinmdpicoarttaencteheofsevvaerrioituys orofuttehse oafcuabtesorhpatzioanrd. Caonrdollathrye iannfdorpmoastsiiobnle rseylnaetirvgeistitcoefsfpeecctsiescanvabreiaboiblittayi,nesdexa,t athgeis, ftoimr ef.uAtulrleo, fmthoirse ienxftoernmsiavteiolnonwgi-ltlertmhenstupdroievside a basis is Ingentheeralclyaseaodfopnteewd sbuybstatonxciecso,lotghiestsfirsotr stienpduwshtriicahl luatbiloizraattoiorniesofinscrteheenindgetetersmtsinoantioenxpeorfimtoexnitcailtyaniismathlse aTchuetsee efaferectsurseusaullltyingfofllroowmedsinbgyle dinejteacilteiodn,stiungdeiesstionof, oefrfecitnshoanlatsikoinn aenxdpeeryiemseanrtes. evIanluaateddd.ition, irritating forInan195e6xtaencsiovmeplseetreiescomofpimlaatitoenriaolsf awcauste ptuobxliicsihtieeds u(5n).deTrhethpeurapuospseiceosf tohfisthveoluAmeerowaMsetdoicbarlinLgabtoograettohreyr afovrailasbevleeradlataspoencie"sacuotfe tcooxmicmityonolyf vaursieodus lsaubbosrtaantocreys aisntirmataiolsn,asordeintehramlaitnieodn, boyf ofaratall odrospeas.r"enItnerathl eadinmtrino ddiutciotinosn intoflutehnicsinvgoltuhmee acthuete vtaorxioicuisty sifgonrifiacnaynt gicvoenn cthoempraotuendofwaebrseordpitsicouns,serdo.utTeheosfe adinmcliundisetratthioen,dossiete, eonfviinrojencmtieonnt,, atnedmpoetrhaetur rein,flhueanbcites,anindcltuodleinragncdei,seaestec, Icnhemadicdaitlsiown,illitvawrays wpiothintsepdecioeustofthaantimthaels taonxdicistoymoef Wtimitehsinevtehne wsaitmhedsiftfrearienntthsetrationxsicoitfy thmeaysamdieffesrpewciietsh. age, weight, sex, and general condition of the animals. WILLIAMS 991 Btoecbaeuseceorftaainll tthheaste avllarieaxbpleesrimiteinstsviratruealclyonidmupcotesdsibilne fpirnedcisdeelytaitlheed sdaimsceuswsiaoyn. Ionf faalclt,suocnhly fraacrteolrys dionevsolvoende in Faonlloewxipnegrimaecnctu.mulation of data on acute effects, ilnohngal-atitmioen, cfhereodniincg, eifnfejecctstioanr,e anthdenskisnt-uadbiseodrpttihornouegxh preesruimltsenotsf. eTahrleiernastcurreeenoinfgthteessets.isAdtetaercmoinnfeedrenbcye tohne Tinhe195T9ox(i6c)olVo.giKca.l RBoawsies aonfd ThhisreschoowlodrkLerismpitreVseanluteeds awnhicehxtehnasdivebeesnummmaadrey ovoefr tahepekriinoddsofofmoobresetrhvaatnion20s syuemarms abriyzedsevaenrdal tainbduulastteridalobgsreoruvpasti.onTshoisn dmisocrutassliitoyn, ofogoyd, minitcarkoep,atbhoodloygwy,eihgehmt,atoorlgoagny,wbeliogohdts,urgeraossniptraotgheonl, cchlionliicnaelsteurraisnee. analyses, central nervous system, and paTrtaicbulelsarI-eIfVfecstsumwmeraeriozbinsgervtehde ufrnedqeurenvcayriowuisthciwrchuimch setraanlcebsiogloivgeicananidndibciaotciohnemoicfalthedestiegrnmifiincaatnicoenso. f Tsehve sTiganbilfeiscaIncaendofIIgraonwdththestusdiginesificaanndce cohfoltihneestleivraesreanind kinidTneaybleins IaIlIl aonfdthIeVs.eTshtuediaeusthaorres w(6e)llpodienmt oonusttrathteadt kthinedres iosfinmcreeaassuinregmpernetsssuirne tfhoer mbioorceheamndicamloarendpretocixsie cologic fields as a means of establishing valid threshold leixmcietlsl.enTtheoybjepcotiivnet oauntd, hoonweevtoewr,atrhdatwwhihcihle atlhlisshisoualnd sutsreiveo,f itaviasileasbsleentmialantphoawt eorneanmdakfeuntdhse mtoosotbptarianctitchael mseot stfomrtehaniinngftuhlisinpfoaprmeratiaorne. tThhosee crwitheirciah wahreichmaorset wthiedeflyieldu.seTdhaendbecsterthaoinpley faocrceipntcerdeasbiyngallouwrofrukenrds ionf kconmowelefdrogme dthereivdedeveflroopmmenatniomfalnewexpteercihmneinqtuses maunsdt snteawte:criteria. In summary, the authors of this paper newIn csriptietreiaobfeitnhge dfeavcetlotpheadt atnhderteesaterde tmodaanyy, vthaeludeatoafprceesretnaitned ohferetihne emolpdhearsizcerittehreiah. igIht wthoouseldstsuedeimes ownhliychpreuxdpeernitenctoe hmaaskeshouwsen toof boenlymothstosperocdruitcetriivae.shTohwisindgoeas hniogth mdeeagnreethaotf pefofirctieedncyherieninthsehosuelrdiesbeofusiendv,esbtuigtatcioenrtsainrley itot xsicuoglgoegsitcsalthasttudthyeydesshigonueldd btoe bdaestiecrmtoineanya threshold limit for repeated exposure. anOd nemoorteheratsteetntoiofncriatereria thwohsiech pihsysaitotlroagcitcingstumdoieres wInhicthhecasnymbepomsiaudme omneanntiiomnaelds aasbwoveell, asDro.n JhouhmnanAs.. Zphaypspi,oloJgr.ic (7o)bsedrivscautisosneds stuhceh iams psoyrsttaonlicce anodf duitailsitzoinligc T able I FREQUENCY WITH WLHEIVCEHL AATPWARHTICICHULAANRY EEFFFFEECCTT WWAASS OOBBSSEERRVVEEDD A(6T) THE LOWEST DOSAGE Crietfefreicat of GHreomwatthology CCNlinSical urines Cholinesterase Oral a 641 ((71792) ) 41 ((170)9) 8 (10) Data from 1952-1959 - Vapor % a % 371.3 161 ((3281)) 425 81340.7 01 ((372) ) 03.1 Da2t2a-2f5roymearlsast All routes a % 1525 ((411700)) 372.9 25 ((14431) ) 43..56 8 (10) 80 Number of positive findings (number of observations) T able II FREQUENCY WITDHOWSAHGIECHLEVAELPAARTTIWCUHLICAHR AENFFYECETFFWECATSWTAHSE OSBOSLEERVEEFFDEC(6T) AT THE LOWEST Crietfefreicat of GHeromwatthology CCNlinSical urine Cholinesterase Data from 1952-1959 Oral a % Vapor a % 205 ((17792) ) 105 21 ((2318)) 55 40 ((170) 9) 03.7 01 ((372) ) 03.1 4 (10) 40 Da2t2a-2f5roymearlsast AH routes a % 441 ((411700)) 110.6 05 ((14431) ) 03.5 4 (10) 40 'Number of positive findings (number of observations) WILLIAMS 99B ateprpmliscatoifonthtoe hsuigmnaifnisc.ance of such information in maItnerisaulcsh wahnichexteanrseivesolisltittales tuhsisedthtehreat artehermeaniys Human Experience While animal data provide some basis for judgment nsteagnldigairbdlse pineodpulset.riFalorexsupcehriemncaeteraivaalsilarebllieantcoe aisssipstlacoeudr primarily on animal experiments and the use of abbeouustedthseafpeolyssiinbleinldeuvsetlrsy,ofthteoyxiccamnnaotet rbiaelsexwtrhaicpholamteady to humans with complete confidence. The ultimate anFaloorgythaes gmuoidreescionmsmeottninginldimusittrsial chemicals many years of experience in using them has provided the cvrailtiedriitay omfussut chcomcreiterfiraomis bhausmedanonextpheerieanmcoeuntThoef experience in terms of both numbers of exposed nSeuccehssaerxyperbiaecnkcgeroiusndgenteoralvlyerifoyf aexinsteignagtivsetanndaaturdres. Where it is supported by clinical or physiological data epveaolpulaetioanndoftimthee oefffeecxtspoosufret,heontoxthice mmaettehroiadls oonf people, and on the completeness of the evaluation of cthoerretelant-eydeawr istthudlyevoeflsbouftylexaplcoosuhroel, bays Sitnerntheei acnadse hoisf colleagues (10), the information is most significant. j | oefxptohseusree lleevveellss winiththehuemnvainronemxpenotsuraend Dcaotrarelwatiitohn reference to human effects are obtained from both geSnuercahl mpheydsiiccaall pcroongdriatmiosn aorfe edmepsilgonyeedestaondevatoluiantcelutdhee specific physiologic tests which may be expected to j I I cexopnotrsoulrleesd. experiments and industrial environment In the case of irritants, for example, such factors parreovibdye feaarrlytheevimdeonsctevoatluianbjlueryforStuedstiaebsliosfhitnhgis vtaylpide hygienic standards j aesxpoodsourre dwehteicchtioanr,e sirernistoartiyngretsopoenysees,, skainnd, alnedvelusppoefr respiratory tract have been studied quantitatively in SUMMARY AND CONCLUSIONS hstuumdiaens,s cuonmdberinecdonwtroitlhledexcpoenrideintcioensgaiInnedgewneitrhal,acstuucahl forIninshuamlamtiaorny, iint ctahne boeccsutaptaetdionthaalt hheyagltiehnifciesldtanindarthdes porlancot nufisrem, ipnrgovhiydgeieannic asdteaqnudaatredsbafosirs sfuocrh essutabbsltiasnhciensg. bUensittekdnoSwtantebsioacrheembiacsaeld, toonxicothloegiac,ppplhicyastiioolnogioc,f atnhde hItumisamn uecxhpemrioernecediffofircuslut btsotapncroevsidwehiachsoruenqduirbeasirseloaf epxaptheorileongcice. tIencvhensitqiguaetsiontso araenimcaarlrsiedanodn tboy hpurimvaatne toifveilnyjulroyn.gWpehreiroedass othfetimaceutbeefeoffreectpsrocadnucbinegeevvaildueantecde ienrdnumsetrnyt,alunaigveenrcsiietise.s,Trheeseaarncahlysliasbooraftosruicehs, daantda gaonvd rdeeltaatiivleedly srtaupdiidelsy aonfdcobyntrsoimllepdle gprrooucepdsuroesf, ilnodnug-sttirmiael ibnytesrtparnedtaatridosngirnoutpesrmcsomopfohseydgieonficcosmtapnedteanrdtsscisiendtoisntes wthoerkecrasseareofretqhuoisreed stuobsptaroncveidse wadheicqhuatme aeyvidpernocdeucine rfieepldresTenhteingvaleivdeitryy offactehteseofsttahnedaordccsuipsatdioemnaolnshtreaatlethd chTrohneickiinnjdusryo.f information which are available from bUynittehde Slotawteso.ccVuepraiftiieodnaclasdeisseoafsesuacthtaciknjuraryte airne tthhee itnhdreuestrbiaaslicexcapteergieonricees. wOinthe voafrithoeusse cihselmimiciatelsd ftaol-l cionmto resMulatnyof aepxpproosaucrheessfaarreabboevinegthme aedsetabtolishtheed lpirmoibtsle.m . oprlawinitths masosoreciasetevderegefnoerrmalslyofwaicthutethierristeantisoonryrereascptioonnsse ohfeaelsthtabfliieslhdingIthybgecieanmice sotabnvdioaursdssoinmethetimoeccuapgaotiothnaatl I | aseffceocntdingkinskdino, f edyeast,a orersuulpt pferromrescpliinraictoalryextaramcitnaTtiohne rinesesaormche cpaeseospluetiliinzinvgarvioaurysinpgartteschonfiquthees wAsoraldrewsuelrte, sJ ' otofxeicxoploosgeidc wororpkhmyesnio. lToghiec tshtuirddieiss. tTheo rebseulotfofvahluume ainn ovardlueers offormsaogmnietusduebstIanncaens adtitfefmerptbytoasgemt uscohmeasunani - etsitoanblimshuisntg bheygcioernrieclastetadndwaritdhs saudcehqumateedidcaaltainrfeolramtinag pfircoavtiiodne ina thmeecbhaasnicismapp1r0oacphertmoitthea pmroubclehm barnodadetor % | etoxpothseed.concentrations to which workers have been ehxecahltahngewoorfkeinrsf,ormthaetioPneramndandenatta Ianmteornngatoiocncuapl atCioonmal I j StaInndahridss pfaoprerD"aIilmyprIonvheadlatCioonm"mSumniyctahtio(n3.) Hreyvgieiewneidc mtoisssitoundyonthIinsdupsrtoriballemM.edTichiinse sSeutbucpomamSiuttbeceomhmelditteae ; G2o3v8ervnamluenets-!froInmdutshtreial19H5y6giAenmisetrsiclainst, Ctoogneftehreerncweithof soyfmTpooxsiicumSubosntanMceasxiinmuInmdusAtrllyowinabPleragCuoe,ncCeznetcrahtoisolnos- j! huiasteidnttehreprnetaattuiroen ooffththeesseupvpaolruteins.g Hdeatah--asanailmsoalevanald Svaykmiap,osoinumA, pwrilhic1h4-17a,pp1e9a5r9edThine Tforaunrsascetciotinosns,of dtehael hhuummaann. dAanta ainnadliycsaitsesofthteherofleouorf ksiuncdhs eoxfpesoriuernccees ionf Twhitihs gsteanteermalenatreoafs porfinacgipreleesmiesntanamimonpgorttahnet dfeirlsetgastteesp. eOsftaablitsohtianlgofhy2g3i8envicalusetsanwdahridchs iwneretheanaUlynziteedd hSutmataesn. ipnoretastnatblfiisehldingOinntethrneatbioasnisal ocfotohpiserawtioornk iint itshihsopimed dCatlainiwcaelreEuxtailmiziendatiionn1o0f8*W, doirsktmribenuteWdasas follows: onfot aonlsyertihesat wofe ciannterlonoaktiofnoarwllyardatcocetphteabdleevehloypgmieennict ICnodruresltaritaeld CWoimthplaTihntesirorExOpbosseurrveations 34 swtaitnhdarerdgarvdalutoesgebnuetratlhaptrinacgirpeleems eanntdcaton mbeethoobdtsainanedd LHeusms aQnuaSnetnitsaotriyveDTathaan Clinical Observations 4323 porfoscuecdhuresstanwdhaircdhs.wTillhebepuretisleiznetdSiynmtphoesiuesmta,bwlishhicmhenist Human Toxicologic or Physiologic Data 10 t*h0er/ethwee1r1e91v1aludeuspldicisattreisbuwtehderieninthetheabosavme etabmualtaetrioianl wthiell, seIcohnodpe,uncdryesrtatlhliezeaeuvspenicefsurothf etrhetheSutbhcionmkimngitteoef those in the occupational health field concerned with wapepreeaarecdtuaullnyd1e0r8 tsweoparoartemsuobrestahnecaesdinagnsa;lyztehdu.s there esasfteabilnisdhuinstgriaslouenndvirsotnamndeanrtds.s to be used in assuring 998 EEcckkharadrdt,t,RWob.e, r8t5E0-.,8577-10, 64-65 Elkins, Hervey B., 981-983 Erhardt, J, Th. G., 850-857 Estadella-Botha, S., 663-668 ' Fabre, Ren, 686-692 Felton, J. S., 413-426 Ference, Anne M., 12-14 Ferran, G. H,, 486-503 Fiandaca, S., 353-359 FFiisncuhlelir,,MR..,, 787702--787726 Fisher, R. E. W., 250-256 FFoorlsmomn,eMk,aJr.i,o7n14B-.7, 2712,-88272-876 FFoorrsnsemllsa-nM, aSrvteinn,ez6,8-E7.2,,626537--626588 Fortuin, G. J,, 258-259 Fournier, Et., 694-698 Frad, G., 259-260 Frantik, E., 714-721 Frantikov, D., 872-876 Friberg, Lars, 201-203, 977-980 Friedland, I. G., 692-694 Gabor, Sylvia, 465-466 Gasque, Mac Roy, 260-263 Gaultier, M., 694-698 Georgescu, A. M., 343-345 Ghosh, P. K., 426-427 Gillquist, B., 257-258 Glorig, Aram, 699-700 Goldman, Rose, 314-316 Goldstein, Bernard, 263-266 GGoorldosstpeei,n,ADlfarevdido HA..,, 266366--267309 Gradina, C., 700-702 Grant, Ellsworth S., 118-120 GGrreimenaeld, iK, JaotrhinneVR.,.6C0.7,-361048-316 Grimlund, K., 703-707 Gross, Paul, 707-712 Gucciardi, G., 259-260 Guymer, R. F., 270-275 Guyotjeannin, Ch., 694-698 Gwozdz, B., 795-798 Hamilton, Gilbert L., 656-661 HHaarrgrirse,aEv.esS,.,M2a81rg-2a8r3et S., 275-278 Harris, William B., 466-472 Hatch, T. F., 839-845 Hayes, Wayland J., Jr., 120-122 Hertig, B. A., 839-845 Hinchcliffe, R., 712-714 Hine, C. H,, 281-283 INDEX OF AUTHORS HHiipnpksle,,JLohanwrGe.n,c6e08E-.6,1J0r., 283-288 HHoolgdaenn,, EFd. wRa.,rd28J1.-,268130-613 Holm, A., 257-258 Holmquist, Carl-Eric, 122-126 Holstein, Ernst, 278-281 Holtz, John, 783-785 Horiuchi, Kazuya, 288-289 Horvath, M., 714-721, 872-876 Hueper, W. C., 473-486 Hughes, James P., 879-882 Hyatt, E. C., 486-503 Inoue, Toshi, 289-290 International Labour Office, 721-724 International Symposium on Maximum Allowable C33o-n3c9entrations of Toxic Substances in Industry, Iorga, M., 341-343 Jensen, C. R,, 486-503 Juin, Grard, 942-947 Jullien, Georges, 724-726 Kammer, A. G,, 427-428 Kantor, M., 753-755 Kazantzis, G., 290-298 Keatinge, Gerald F., 298-301 KKeehenoae,n,RRoboebretrtAG.,.,12560-31-2590,6,43738-34-37685 Kesy, Irena, 726-730 Killens, Richard, 783-785 King, E., 301-311 Kingston, James R., 911-917 Kitagawa, Tetsuzo, 506-512 Kiviluoto, Raimo, 311-312 Klein, Irvin, 613-615 Klutas, Edna May, 428-431 Kopp, John, 783-785 Kruger, Daniel H., 615-621 Krger, P. D., 971-973 Kubota, Juko, 313-314 LaBelle, Charles W,, 730-735 Lachnit, V., 947-950 Laham, Souheil, 686-692, 735-738 Lammers, B., 876-878 Landry, A. S., 512-519 Lavergne, Rafael, 214-217 Lehmann, Gunther, 878-879 Leoca-Radu, Mina, 349-351 LLiebtearv,eAt,mAo.uAr.,F4is3c1u-4s,337,3889-714-8092, 983-987 Lieben, Jan, 316-319 Lienhard, Wendell F., 879-882 Lillis, R., 679-681 INDEX OF AUTHORS 999 LLiinndch, ,AA. .RL.,.,88528-08-85785 Liniecki, J., 800-801 Littler, T. S,, 712-714 Lubin, Isador, 621-622 Lund, O.-E., 740-741 Lundervold, Arne, 887-891 Lutier, J., 401-402 Lutz, Earl F., 184-186 McCallum, R. L, 741-745 McClintock, R. S,, 879-882 McKerrow, C. B,, 745-749 McNerney, James M., 707-712 Magnuson, Harold J., 129-131 Malysheva, A. E., 891-892 Manheimer, Robert H., 314-316 Matthews, James, 131-134 Matuoka, Syukiti, 893-902 Maxlield, Mary E., 857-862 Meiklejohn, A., 134-138 MMeetilzan,eIr.,, F67r7a-n6z78N., 316-319 Michon, R., 902-904 Mihaila, I., 904-908 Mikaelian, Michel, 320-322 Mikisha, A., 714-721 Milijic, Bosko, 950-951 Miller, S. E,, 937-939 Milox, M., 908-911 Minard, David, 911-917 Miskolczy, Wilhelm, 322-324 Mitchell, R. N., 486-503 Moise, Gh,, 676-678 Molfino, F., 952 Monaco, Alfred, 749-753 Morris, George E., 324 MMoorscroowvi,ciC, .BS.,.,374513--374535 Moss, N. Henry, 182-184 Motley, Arthur W., 623-624 Mountain, John T., 783-785 Moyer, Burton J., 519-522 Muica, N., 679-681 Murray, Robert, 139-145 Nadudvary, George, 465-466, 755-757 Naie, Thomas W., 625-628 NNaesmtobrae,sTcua,tsBu.j,i,67795-76-87158 Newnham, C. T., 324-325 Niebroj, I., 795-798 Nixon, James, 699-700 Noro, Leo, 326-335 Norviit, Lembit, 952-957 Norwood, W. Daggett, 335-338 Nystrom, A., 257-258, 653-656 Olloqui, Fernando Flores, 628-631 Oyanguren, Hernan, 227-230 Pafnote, Maria, 845-847 Paggi, Edoardo, 758-767 Pancheri, Giovanni, 145-146, 767-768 Parker, H. G., 147-150 Patrascu, M., 465-466 Payne, William W., 473-486 Pendergrass, Eugene P., 768-769 Pendergrass, Henry P., 768-769 Perales y Herrero, Narciso, 631-632 Pernis, B,, 770-772, 817-818 Pesce, Giuseppe, 958-959 Petrescu, Leonid, 661-663 Pettinati, L., 348-349 Petrovic, Lj,, 338-341, 368-371 Phillips, A. M., 553-556 Pietschmann, H., 947-950 Pilt, L,, 341-343, 679-681 Piotrowski, J., 780-782 Piscator, M., 201-203 Plumb, Carl S,, 260-263 Plummer, Norman, 283-288 Poleti, D., 338-341, 368-371 PPoowttelers,, AW. ilLlilaomyd,E.1,5305-11-53553 Pradel, J., 522-531 PPrreindcai,, NFr,,a3n4k3,-433453-436 Puertas, Benito Nogales, 633-634 Quer-Brossa, S., 663-668 Quigley, J. A., 65 Radcliffe, J. C., 65-66 Rdulescu, I. C., 343-345, 679-681 RRaaein, sSfoterwd,arSt.,G7.7,23-4757-6348 Rasetti, L., 348-349, 359-361 RRaeeuvceh,erA,.KLaorul,is3e4, 96-3345-1635 Renker, K., 917-921 Riedesel, M. L., 839-845 Riegrt, A. L., 819-825 Rgner, K. G,, 257-258 Risquez-Iribarren, Rafael, 155-158 Rogan, John, 772-776 Ross, W. Donald, 351-353 RRoossssii,erM, Par.ioH,.,96707-69-67180 Rotta, C., 353-359 Rubino, G. F., 359-361 Rye, W. A., 361-364 Sakai, Yoshimichi, 158-162 Salmowa, J.,^780-782 Sands, Frederick W., 531-532 Santillan, Jose S., 636-639 Sarfeh, R., 436-438 Saruta, Namio, 532-535 1000 INDEX OF AUTHORS Savicevic, M., 338-341 Sawyer, William A., 438-441 Udel, Melvin M., 397-401 Ursoniu, C., 676-678 Scansetti, G., 348-349 Scheel, Lester D., 783-785 ' Schepers, G. W. H., 786-795 Schermerhorn, W., 850-858 Schiller, Hans, 961-962 Vacher, J., 401-402 Schindl, Karl, 364-365 Schmidt, Heinz-Gnther, 365-367 Valentin, H., 810-817 Van der Velden, W., 850-857 Schmidt, Marjorie D., 367-368 Schmidtke, H., 921-923 Van Liew, Hugh D., 911-917 Van Valzah, H. J., 678-679 Schulte, H. F., 486-503 Schunck, Karl-Hans, 377-378 Vigan, C., 965-971 Vigliani, Enrico C., 87, 452-457, 770-772, 817-818 3 Schwartz, Louis, 639-642 Seles, L., 237-238 Viles, Frederick J., Jr., 556-563 Villarroel, Sergio, 227-230 i1 Serati, A., 963-965 Sherrill, S. S., 281-283 Viola, P. Luigi, 818 Voelz, George L., 564-569 Shipman, Thomas L., 642-645 Vosburgh, B. L., 931-933 Shoib, M. O., 85, 162-166 Sick Absence Statistics Committee of the Perma nent Committee and International Association on Occupational Health, 40-55 Silverman, Leslie, 441-448 Wade, Leo, 7, 61, 88 Wald, Neil, 569-572 Simpson, H. Marjorie, 448-452 Simu, George, 755-757 Walker, Mildred I., 167-169 Walsh, Richard F., 645-648 Smith, Paul E., Jr., 857-862 Sodergren, David, 122-126 Warnock, Dorothy M., 402-404 Wassermann, M., 572-580 Sox, Ellis D., 281-283 Spett, K., 795-798 Weaver, Neill K,, 381-387 Wechselberger, F., 191-194 Spiers, F. W., 535-540 Spioch, F. M., 795-798 WWeeslltsr,icRk., LMomaraiaxn, 1L7.0, 707-712 Stankovic, M., 338-341, 368-371 Staskiel, L. J., 753-755 Wetherhold, J. M., 580-585 Wheatley, B. M., 585-587 Steele, Earl C., 371-373 Steele, Margaret L., 66-68 Whipple, G. Hoyt, 171-178 Whitney, L. Holland, 283-288 Steiner, S. D., 373-377 Stokinger, Herbert E., 540-544 Wiecek, E., 801-805 Wieland, H., 740-741 Stopps, Gordon J., 857-862 Stowell, Thomas E. A., 186-191 Williams, Charles R., 988-994 Williams, Katherine, 587-590 Strange, John P., 544-551 Sumner, Philip, 314-316 Williams, May M., 194-197 Williams, N., 819-825 Symanski, H.-J., 798-800 Szpakowa, T., 800-801 Willman, Helvi, 404-405 Winter, Kurt, 405-410 Szymczykiewicz, K., 801-805 Worth, G., 826-827 Wyndham, C., 924-931 1 Tabershaw, Irving R., 11-12 Taylor, Edmund W., Jr., 182-184 Teisinger, J., 987-988 Teso, G. A., 359-361 Thaxter, M. D., 147-150 Thom, W. F. J. M,, 379-381 Thoma, George E., 569-572 Thompson, A. R., 301-311 Thorpe, John J., 381-387 Tompkins, Paul C., 551-553 Tripsa, Rodica, 806-810 Troisi, Fortunato Maria, 387-397 Truhaut, Ren, 33-34, 39, 209-214, 686-692 Tucker, F. E., 553-556 Yingling, Doris B., 457-459 Yoder, John D., 590-592 Yoshimi, S., 827-828 Yount, Hubert W., 649-650 Zahorski, Witold, 828-832 Zanetti, Ennio, 767-768 Zannini, D., 971 Zielinski, John F., 592-600 Zorn, O., 971-973 i--