Document EdXXZxKK7gL32QJzd7MkE3qqn

AR226_ 1113 il fr 15 July 2002 ng Charles M. Auer, Director Chemical Control Division US EPA - OPPTS `Washington, DC 20460 Ref. EPA-SNUR Dear Mr. Auer: 32 5o3 y g&eH SA = 85 5& "Thank you for your letter of 2 July 2002 and the helpful information. FIR1EhSavEeRVbeIeCnEiJnOcIoNntTacMtAwNitAhGNEIMOESNHTanWdElLeLanNedESth--SereFIiTs NaEsStSakIeNhIoAldTeIrVEo.rg"aniIzatsieonnt "THE them selected information from my files and directed them to the EPA web site for more current information on the subject. While I followed-up with several phone calls to Mr. Richard M. sDeunffdyt,hAesmsiastcaonptytoofythoeuGren2eJrually P2r0e0si2delnettt,erI thoamveenboecraeusspeonssuechyeitnfforrommattihoatn sorhgoaunlidzabtieonh.elpfIuwliltlo theirprogram. (ref. Enc. 1) on Ianhyavperaolgsroabmeteon dientceocnttaacntdwpirtehvesnotmesuDcehpuanrntemceenstsaorfyDreifseknsstehaatctimvaityieesf,fbeuctt thhaevesanfoetyr,eshpeoanlsteh. and long term quality (Mil-F-24385F) AFFF of (a life for DOD fire POS compound). fighters and other personnel exposed This Primary Fire Fighting Agent has to Mil Spec been used by the DOD for over 40 years 1 was surprised to learn there are some within the fire fighting community who seem reluctant to welcome medical monitoring that might intrude and/or relate to the habits of their members. So, trying to protect personnel against such unnecessary risksofPFOS compound exposure may be a hard sell. But that should not keep conceraed leaders from making the necessary efforts to protect the safety, health and long term quality of life for the fire fighting community and the Marine Ecosystem. Since I don't have a medical background, I appreciate your corrections and clarification to my interpretationofthe: EPA-TOX/2000 18 Oct 2000/t0 2675; C. HEALTH EFFECTS (Pg. 62326) of EPA-40CFR-721 OPPTS-50639; FRL-6745-5 RIN 2070-AD43 document. (Enc. 2) othe1rcPomEmReFndLUthOe REOPAAYLfLoKr SitsULcoFnOtiNnAuTinEgSinPveEsRtiFgLatUioOnRoOfOfClTuoAriNnOatIedC compounds, including ACID and its SALTS, and the FLUORINATED TELOMERS. Should the investigation lead t0 rules limiting the use of this classofcompounds in fire fighting agents the Industry is well prepared to deal with such an event. areIsheavevrealovCeormm3e0rcyeiaarls-oOffefx-pTehrei-eSnhcelefi(nCtOheTSb)ussionleustsioonfsfifrreopmrottheecItnidounsatnryd tchaant awsosuulrde yeloiumitnhaetree CONTAIN NO CB! I the Environmental, Safety and Occupational Health risks now attributed to AFFF type fire fighting agents. Some of these proven COTS technologies would also providea significant increase in fire fighting extinguishing performance capability that would benefit the general `pumbilsisci,onhroemqeuliraenmdenstesc.urity efforts and the Department of Defense needs to meet the 21* Century Dealing with the ESOH issues regarding this class of compounds provides the industry an opportunity to make a breakthrough increase in fire fighting capability. It would also result in very affordable fire protection platforms/systems for most, if not all, current AFF applications. If you know of any stakeholders that would provide the leadership and resources to promote environmentally sound, improved fire fighting performance standards, I would greatly appreciate knowing of such contacts. 1 would follow-up with those people/organizations to help move the effort forward. 1would like to take this opportunity to thank you for your efforts to be helpful and wish you continued success at EPA. FO Brie-- Very rly yours, 1D. Dunne `The 8N Corporation 223 Carthage St., Suite 2 Sanford, NC 27330 Phone: 919-774-1187 Fax: 919-774-1047 ce: Dr. Kenneth Moritsugu Mr. Richard M. Duffy 2 --- ave-1 fH 2a2 207 = pqpy RicharMd. Duffy DIinsteesmtaotrioOnaHl&ASssociationofFire Fighters, AFL-CIO, CLC D1e7p5a0rNtemewntYoofrkOcAcvuep,atNioWnal Health & Safety WFaaxs:hi2n0g2t.o7n3,7D.8C41280006 Subject: EagPeAntRs)ecommended Medical MonitoringofFire Fighters For Effect of PFOS Exposure (AFFF Gentlemen: 1 was advised that your organization is occupational health and safety risks for fire actively fighters. involved in efforts to eliminate unnecessary Com`pOnoeunodfsth(ethleatemsatjoidrenctoifmipeodnoecnctupoaftiMoinla-lSpheeacltMhIaLndF2s4af3e8t5yF,risakpfroirmfairrey fAiFghFtFersfiisrefxipgohstiunrgeatgoenPtFOfoSr ARFF applications). conEtinnculeodseedffoisrtssetloecptreodteicntftorhmaftirieonfitghhattinwgilclomemnuanbiletyy.ouIntothiasccpeasrtsicmuolrareadpeptlaiiclaetdioinn(foArRmEaFti)onallfporeoypolue iinnftohremaatrieosnarbeeienfgfegcattehd,ereevdebnyatfheerEtPheAffiroer tisheoSutNaUnRdwtihlelcaliesaon-leuapdtcfoforretsgucloatmimoennsfcoe.rotIhteirscloimkeployutnhadtsthien this class (used "The current diantcaomclmeearrcliyaclonfofrimrumlsattihoensn)e.ed for the EPA suggested Medical Monitoring to protect the ongT:atlesrombqeulaileivteytohfel3ifMe fdoerctihseiofniretofitgehrtmeirsn.ate production should provide the impetus for the industry to (nCoOwTSc)onssoilduetriOopnesrtahtatioenliamliRnaetqeuitrheemEennvtisronamsentthael,bSasaifsetytoansdelOecctcupalatteimoantailveHeaclotmmherricsikaslt-oofffi-rethfei-gshhteerlsf aanndd riemsporuorvceesex1t0iandgduriesshsinsguccahpaabiPlietryf.or1maanmcelBooaksiendgafpoprraoanchor.ganTihzeatiSotn/aasctiQvuiotyatphpatrohaacshtwhielllenaodtermseheitp 21*UCnfeonrttuurnyatreelqyu,iIrdeomne'nttsosefeDmOuDchainndd/uosrtrHyo/gmoevlearnndmeSnetcureifftoyr.ts to solve the problem. These stakeholders AsFeFeFm.coBnutte,atthtaot'sSthuodyw twheegoistshueersewiitnhtheemfpihrsatspilsacoen(maantdcihtidnigdn'tthewophryksfiocralhaalnonds)c.hemInicfaalct,pmroopsetrtpieeosploef are surprised to learn that the original Navy report (NRL Report 6057) never recommended AFFF as a fireTehxtaivnegu3i0shyienargsageexnpte.rience within the fire protection industry and a unique OUTREACH NETWORK Sotfanedxapredrsiewnictehdinptrhoefeisnsdiuosntrayl.s wIofrwkeincgantoeveirmpbreovofe hreelapl tolifyeoufrireeffforitgsh,tipnlgeaesxetgiingvueimsheinagcaPlel.rfoWremawniclel `gOicvceuopuartivoenrayl bHeesatltefhfroirstktsofhoerltpheprfoivreidfeigihmtpinrgovceodmmcuanpaibtiyl.ity while eliminating Environmental, Safety and forIafptphriospsruibatjeecctonistancotts.thIe'lrlefsoplolnoswi-buipltayonyflyeoaudryoorugapnriozvaitdieo.n, I would appreciate your recommendations Very%) yours, SOW arinni_-- I"TDh.e D8uNnCnoerporation 2Sa2n3foCradr,thNaCge2S7t3,3S0uite 2 PFhoocne: 991199-7747-4-11014877 3 Enc- | J ~ThWeellnFeisres-SFeirtvniecsesJIoniinttiaLtiavbeor Management : @ 4 Second Edition = 8B, 5% pe 8B cocasio A 7/74 4 7% =) ez WE @ Se r>e ~%e -- HE &) ge 22 = (CmiE | rea = al g Ry ri= :; dR Lwapy Rpernbeyocopdii, XoSpuEof mty be aenom lspd de orn Copyright 17, i by the JperatonadAsodaton of Fire Fighters. All JAFC and the ten cities and local unions oftheTask Force. Thispublication is International Associationof Fire Fighters. Intemational Standard Book Number: 0942920368 HH deveElvoepraynfoivreerdaelplawretlmlennetsisnfictonoepsesrsaytsitoenm twiotmhaiintstalioncaulniIfAoFrFmaefdfilpieartesomnunselt pahgyrseiecmaelnatndtomiennittiaaltecaitpambiliutbese.msuWtRutialle sbuecthweaepnrothgeraadmmminaiystbreatmiaonndaatnodryit,s mmuesmtbbeerpsosrietpirveesaenntdednobtyptuhnietliovceailnduneisoing.n;Arneqyuiprreomgarnadmatoofrpyhpyasritciaclipfaittnieosns abgye,allguennidefro,rmaendd.peprossointnieolnininthtehdeepdaerptamrtemnetnotn;cealilmopwlemfoerntoend-;duatlylo-wtifmoer pdaerptairctimpeatnito;n purtiolviizdiengffoarcilriethiaebsialintdateiqouniapnmdenrtemperdoivaildesduoprpoarrtrafnogretdhboysethien enqeueidt;abcloenttaoianlltrpaairntiincgipaanntds.edTuhceatpironogcroammpomnuesnttsa,ddarneds,sbteherefaoslolnoawbilneg aknedy pois Confidentialityofbehavioral, medical, and fitness evaluations Phryeshaibcilailtatfiivten,eassndannodt pwuenliltnievses programs that are educational and + Performance testing that promotes progressive wellness improvement Cofmimitt/nmweelenlnstessbsyplraobogrraamnd managementto a postive individualized Develop aholistic wellness approach that includes: MeFditincesasl evaluation RBeehhaabviiloirtaatlihoenalth + Trhetireees.progratemrm,sandh,woheruepolssidbleb,beemaldeaovainlabgle - The Fire Service Joint Labor Management Wellness-Fitness Initiative Task Force FactoFriarold A. Schaiterger, IAF Executive Assistant tothe General President International Assocation of Fire Fighters ARlifcrheadrdK.M.WhDiutteyhe,aDdi,rGeecnoerraoflOPcrceuspiadtenitonal Health snd Sety InternatiConhaleAsFsohciea,tonFooef iCrheitChief Austin, TGeaxraysWFairrerDeenpaFirrtemCehntet Sco A Toupin President, ATE Local 575 Calgary, Alberta Fire Department `BWrayyanneNMeoirlroins,, PFrierseiCdheinetf, IAFF Local 255 Charlotte, North Carolina Fire Department : Luther Fincher, Fire Chief Mike Spath, President, IAFF Local 660 Fax CEoduwntayr,dVSitrgoinniea,FiiereanCdhiReefscue Department R. Michael Mohler, President,IAFFLocal 2068 IndianapTLoooluimissHIAna.dniDiaen,saePFlriareneiDdFeeipnratCrIhtAmiFerFntLocal 16 Los AngeRTlPiecishcaCrhoduanGetuyF,rrCeraelm,iafnoP,rrneFisiaindeFeiCnrhtei,DcAekpTaFrmLoecnatl 1014 Miami DRDaodmeD,ionvFiilcdokrPiBodaaurlFbcieorrens,,ReFPsreceuseiCdhDeienpttaIrAtFmFenLtocal 1403 City of NTKeeovwmiYnVoGeraknl,lEaNsgseheewnr,,YForrreeksCiFdoiremenmDtienIpiAaoFrnFtemLreonctal 94 PeterGorman,Freident, IAFF Loca 51 Phount,"Aflamn BsraHniae,Bovge eChrite Billy Shitd, President TAFF Local 493 Settle, Washinglon Fire Department JCaamerseSeHwaelwlk,inFigr,e PCrheiseifdent, IAFF Local 27 - |reTvhiesfioolnloowfitnhgefIonritmieatriTvea:skForceMemberspartduiricngtihedpevealotpmeentadnd (po InternatiRoincahlaArsds"ocSimaotkieony"ofDFyierre,CPhaisetfsPresident RR.icDhaavriddMPaaruilniuscocni,,PPaassttPPrreessiiddeenntt Austin, TReoxbaisnFPiaruelDsegrpoavret,mPeanstt Fire Chief DMiokuegMFaorwklse,r,PaPsatsPtrPerseisdiednetn,t,IIAAFFFFLLooccalal97957.5 Calgary, Alberta Fire Department JMaucrkrRaoyssC,asPtalset,FPiarsetCAhciteifng Fire Chief Fairfax CGoluenntny,GaViinregsi,niPaasFtirFeiraendChRieesfcue Department IndianapoKleiist,hIDn.diSamniathF,irPeasDteFpiarretCmheinetf Los AngeDlaelslaCsoJuonnteys,, PCaalsitPfrorensiiadeFnitre, DIeApFaFrLtomceanlt1014 `Miami DMaidcek,eFyloDroindna,FiPraesRtePsrceusiedDenetp,arItAmFeFnLtocal 1403 CityofNAerwthuYorrPka,rcNineewlloY,oPraksFtiPrreeDseidpeanrtt,mIeAnFtF Local 854 Richard Brower, Past President, IAFF Local 854 Phoenix,PaAtriCzaonntaelFmier,e DPeasptarPrtemseindtent, IAFF Local 493 Seattle, WPaasulhiHnagrtvoeny,FiPraestDePpreasritdmeentn,tIAFF Local 27 MichaelMilam, PastPresiIAdFFeLoncatl2,7 . PR | | o Er"TChe Ihnteiro naationnael AdssaogBceitahnrtionfn FarinrepeFrigeheteirdseanneeddteheenntedrenrat,pioaWndaelhAsva seocgiaattonerodef BE JSH || h1cechtislownesensgoifhteonmoirnogwoufirefsoeruvincedraeqtuiiroesnt--hatthwEeMeSfrkieeserppeoongudhrertu.neMierfeoatrinmnedgd iA | personnel it today. # | excTithienFgicrheaSlelrevnigceeJfoorinaltl LofabueorvMoalnvaegdeminetnhtiWspeolslnietsisv-eFpirtonceessssIfnoirtitahteiivrehsearsvbieceen.anIn ELI\E|d | | tmohriosgmrsamidnocf!uahmvFeaeniitlnaoaebnslldetton phshrycoscuirgdcihasol,u,titmnhecenumtpbarepolncrtaeossng,sdroaaefnmmidtostfrodieotbnierauells--v.reoCqeduoilriewmstoeaphtnpafyoveemcanttdihdeveerreeWnsenwiseleltlteldntne,esdhssses Harpolad As.TSAscFhaetbrrges BBoomrivee micodmmpedialwevsluaition, fess, nr ness medical Bm | | aCphptaiirasctunosonasneducaeeetquutihcpahtm,ecnhqtiusittpohmreainctta.hle, utFhnirfeoffriimegehtsdeerrpsveiarcsenodhnanEseMlkSenhrooewsnppormnodoveirrdeseaerbemoseuprtognetdhneci(yr0 CI REN | TfErI SF| | eometrgeincycincnidaenptscthhoalyroegqiuiorleecxotrmeemesphyTshiecsale oaudvteprusteanodutocftoemnreessoulvteintaedv,erasne Snidcdpaost acmipiscto taddtreshs peerhoseonfvnierleeffingehstlisngRlaanvdweebmeeeernglepnilccyenrmeescnp,osnssuescshayosstefthme. Ls me | rceocemntentrtenadpsptrooauncihleastehraavlelfy aimlpeletmoepnrtodtuimceedu,ntivaesrks-ablalsyedacpceerpftaobrlmeaanncedtperstosd.ucStuicvhe > [Ry B Michael Brown ||| oLvaebrroarillMcwaehnlialcgcaeasmn/ednnIteAWFseFslsllonceyaslsusnFiitotnnespesreIsmnidfeawnitvpsioespiahtttaiivvceehp,rcaeotahniatbnnirgliiibtnhuattthieanegtFoialrndeediSveeedrlusvocipacitteniJgoocniaanntl PIrCeHsIidEeFnSt | | fSooocmumvsi.cneAe pilulnpitatorie ivmecoivappiapnnprtgsooabhvceahayveoemsnecd1on0mntmepgihatyAttsnim eivdceatthfieimmtee nodec,slsvtaessnkds tboawoseveleldnrecpi asoesmrcifironssrgeumeta ashn.ecsehTiashtteeol sgyrtiicehngafinvtreeo BoiEeidseunatlaitziveeds wjeolinltnleysshavneecsosmmpirtotgerdamthbeamsseedlvoens tthoetrheeciommpmleenmdeanttiaotniosninofthains | document || WTeTelhelpinmgeast-seFgidoetlmnooreftstaheselnecohimepiraehtenisoivaeefiFisretiSoeornrvfimcfeplaJroolioonsvtunLreiatfoboohrmrmeMeeadanpuoeavargeselomntnennyeelt | {liiocmimicsoaemroeaneiksrne.orAisitn,ciehpoleoeamclnttpihgvye,edeapnpnradosgracrnaanaepdmtnadmtbisislshaeoowbuiiinlllrlide,trtfyei.aglIehitzeersasninganinidvfaeiEclatManhcSbtrlcroeeststdpasdotaanavitdbiaeancrsgosesoliltsnehtcorantosbiutolgwneh,aooonrurktd ~ comparisons throughout the fire service. ucnrie"oaTtnhiiosnmcaoonmfpaargeenhmeeetnnwstoirrvekleaoptfrioogjneesoc.gtEraoacnphhpishceyalsleicltyceaddffiivrteenressdeseapinarderwtdemleelpnnatewrsmasesinsrsteuspersweisitennhvtoeeldxvbecydethlthele | udfenipiraorcnhtimoefeffnitcaisna'ldstdetcehhtenaiiIclAaeFldFetxhlpeoeicrratlpsh.uynsiAiocsnalppafrriettsinicedispesanntpt,rso,vgiirtrahemsidneavpinatdarttnimeoeendnsst,easnnsddsetLeAddFFtiolontchaele wcrietahtitohneocfoansporrtiaumc.itTeihsecerIavAiFlcFephraosgfraacml,iaanteddctohimsmeiftfoerdttaonsd prhonveidwaekdnrorewsloeuedrgcee | npeheadseesdotfo tchiosWmellpntehlsissepFritotjneeecsts.ITnihteiaItiveCHasIanEorgaFnisSati,on participated san | TET Li | LAeFlTFdhlarosecepaaltrautsnokiffotonhrpiscreensmaiedevteinent.gssdTainhredecttthserdektehfseoecrpcoaen,rctaoetnnsetitoseftctihnhngiecodafolctcuhoemdmeemniptta.trEetaemcmehenedttecpihanirgctsiwaneenrnet cmwoaaorsndaigrneeaptmroeernsset,ndpteeeprdasrootnnnmeetlnh.tephEtyxespciehcrnitiacnaasdl,vbicesohomarmvsiiowtretaerleeheubatyliltihezpxeerdrocftiehssresoiupoghnyhasoliuaotlnotdghieisnptfr,oorcmfeaistnsioevnsy || coasosridstinwaittehdmteheetwionrgkprooctehedeitngass.kfoFricnaelalyn,dttheecLhnAiFcFalHecaolmtmhittaenedsS.afety Department | mphaTynhsuiaeclaF,livfriiedtSeneeors,vsaiacnendddJwoaeitlnltaLncaeobsllsoeprcrtMoiagonrnaapgmreotmpoeaccnoklta.Wgeel.lTnheessdFeivtneelsospIeniptrioagtriavemsicnocmhpulieetse TKthnAeoFwFflileeodcsgaeleravuibncliee.onp'Wesiotpfhulinednfsos,retvsoeinxcommneocenettiivhnesg,,sd,wesevuegplapotoph,retarenedddbtayopgspeartcohhverefoiorfveeadrlelp8aa0srtptaemlceetnnstot'efsdtashnded | cbpourmtomgimrtoatsmte.dAtidmhdpeiomtrsitoeanlnatvlleyls,ytotfhnooorstmeoanlellnyysdceeoprmavmreitstmrteeengdtisotanoanladwdIeoAlplFtniFenosgcsaffluliulnnyeistohtnersetsioontuavlroclIevnceiedanhttaievvree,. padrnodegrtvaheme.IWCleHrIoeoEfcFtoSphg,insmitnozieestauinnpvdpetoa.rptWpletahhueaddtveheveceelffoooprmteonmftebavmonetrdyhiofonuulelrtioinrmvgoptallnveiemzedeatntithoadrntosiu.oghnheoouTftAttThheeE | Initiative throutghehUoniutetd States and Canad' profesional ieservice ancodSmitpneoccnheentnihtcesai.lnTichtoeamlsmedicitsottnerdiebrumetveiimosnbiooefnrtshhitashmviaesnmcuaaonlu,natlthreeIiftlAeonc,atudstdhureesesdIcsCoHmaImcEiFhtSom,fettnhhteTtIao nskekteaFpottrchcies,s | project current. vq erences EWC 2. Pagel60f34 + m2Se0o0tl0eu,rbilwchiuitbtyeedvapplaeupreesrmolwbeey)r,e3M,orbeStsuapliecfntoeindvaetflerydo.mPTTeharebflleuvoarp4,eocrhpe.pm1ri6ecsasolfusrethineanMdtaherwcahter1, vHEenervnyizryo'lnsimkeeLlnaytw.; vaASlcoucuerocsredsis,nugggDeitssotpe3rMt,shiaottne,svtoilFnaagttieliisaznapdtliaEonfnnfeecdftrsaonmd(/wRoaefrt.erun1)dt.oerwaTahiyerseifsornot 3Wtishtsehesesmnmoverinertosnc.moemWnpitltaehltetphrdeaotpaep,rrteisEeePsnA,twdofauattlaed,, betahnedabAltgereanntscopyomractkaenomfoonrlPeyFOSdspeef(ciRunefli.attiev1e).on iennvfiorromnamteinotnalsugtgreansstpsorsttraonndglypatrhtaittioitniinsg bioaccumu re poefrsPiFsOSt,entalathnodugmhaycurrent 2nd bTihoemoAngietnocryi'nsghadaztaard (aRnefa.lys8)i.s well absorbed TfoorxicPoFlOoSgyisstaudrieevsiewshoowf thheaatlthPFOhSazaisrd [(rage 623261) boeralfloyrmeadndasdisatrmiebtuatbeoslitperiomfarioltyherinptehreflusoerriunmataendd not appear to be further metabolized. Elimination sluilvfeor.natPeRsO.S cIatndoaslsso from the body fe slow m2aanmldeeaonc3cuerlcsihmeimvniicaaatliboontwhohrakulerfri-snleihfaaevned (tbfeeec1ne/2s).folSofleorwu1em,d42P8FfOoSdrayl5s1e/v2e(lasypepairrnosxtihamrnadeteelsyurgegt4eisrted Lsyet/aukrdisyl)o.girnaBmnaasle(edkg)aonnwdatshfeemrpaelhpeoarrtmmeoadnc;koekynisno,etsieacxvoddlaiutfamfeeroebonftcaeidsniesdtinrifbtruhoetmiopanha2r8(m-Vadd)caoykoifonrea0tl.1i9c paramEeOtSershaswersehownnotemdo.derate LDSC of 251 mg/kg. A l-hour LaCcSuOteoftox5i.2cimtgy/Lbyinthe oral routs with a rat eryaetss ahnads nbeoenn-irrreipotratteidn.g mutagenicity studies in tPoFOSthewasskifnounodf rtaobbbietsm.ildPlFOyS iwrarsitnateignagtivteo itnhe five strains of salmonella and did not induce mciocnrdouNnucumtceelrdeoiuisn inrraetpasneatia-nnddovpsireviomoamrtoaeluss.etoAxbdoivnceeirtsymearsrtsouidgwniaemsiocfornotnouPxcFOilSceiutshyavaoesbsasbyee.ernved in aarabdtnorhsmetapuladititoeicseesli,lnuclwlaeuridgehhdtypienlroctsrrse,oapshecyso,nviunglasslitiorvnoesri,nteenasznytdmiendsae,latheh.fefpeaTcthtiescs,evahefecfmueaoccltoisiseagwtieicroeanl hgzybepspoeoarrcvtteeiddviaittny,dRohsperseoussstormfaotn2ikoemnyg,/ksgtc/uonddviaueylssainiodnncsal,buodveaedt.raoAnpdohrvyeexroifsae,thseiegmnesssailsio,vfardtyioaxrgirlchaiencsdy,s rdaeenppdolretttheiedonpbaenitcnrweetaehsne, 1ad.mr5ae-rn3ka0el0ds.mdge/cTkhrgee/adsdaeoyss.e iNnroansmgeoernukfmeoyrcshotlsheuesrstveeirveoefldf,ebcetaysnodnwda1sip3iwdeeks Cdioynsnteoosmotlragseuastlmomewonntakseayt4s.51e0xmghm/gik/bgki/gtd/eaddya.yl,owAtorfodoobdseeyscoonnadssu7mlpwotweieokanss, 0i.en7xt5coesmtsgri/ekvaoet/mdeanyt, at vssaaeclruiuvomalticizhoaontl,ieosntlearbaoonldredhleevpberaletsao,tcheilanlngud,ladrehaytphhoy.apcetritvriotpyh,y, astiaxginai,fichaenptatirceductions in Flaotus.dPoosAsettsnatthiaenlotfwdfeosatphhrisignhgeasntdindootashee2sr-goedfneevre1a.l6toipomanenndtrae3l.p2roemdfguf/cektcgit/svdeawyet,roexpiucrpietpsyourrtsvetiduvdayalt in agitentneetrrheabtiifroicnrhstowfhfgiselpnereirnacgtloiso(enFl twpoausp3s0s)3igonaftifttihhceeanhtFillgyhpeudspetscredianosseetdh.ediAe1ld.l6wmifgti/hrkisgnt/daaydaydose 11/8/2000 lo TTT hae or ginrouthpeditewdo wtoipthidonse4 0.4 mg/ks/day, weze gcdraooynustpisna,ufetdeornlibynitrotthhet.hetAwsoseacloonwrdeesstugletndeorsoeeftigtorhnoe.uppsuT:hpe m0om.o1rtaanldity oe0.fb1fseecmrtgv/ekdlge/vaeddlavyer(saLenOdAEeLf0).f4ecftmogr/lketavh/eedlasye(,cNoOnArdEeLs)pgeecnatenirdvaetllioyow,nestbofafsosebpdsreironnvgedre(dsFu2vcetpriuspoesn)s iwnere PfueopTrebdeoavdleysloowpeoimbgeshnettr.avledRneeviuenzrostthioibsxliecsitdtuedylya,yfsolrlaioniwsiirnneggflceeoxxnpcoaesnrudnrsephyatobsoiucPtaROlSt.hdeevpeloorpemteinstt mtdoo/sxkeigcD/ieldvteaeyvlyeolspsatr.nuiddeiSneiatsgbanlosvieneoffftinehecdtersavrteastlwoepraamednemdnaitlnrasialosbbtietrtroe,expdioacrlitttehydouiwgnehreprateenviasdtleainlgthtdleatyveldhooipsgemhseenrtoafl veSaxirtgienaritnfiaiolcnasnatndwedrevecirsecoaebsrseaelsrveaidnn.omfaAelbtianelosr,bmaolddiyetliwaeeysiedghotfoPsRstaOiShnfedidcuslareitnigisnnoginof,figceaatsnnhttedateisiyknoeecnireweceaerssees in dg2ei1vn8ei0lloarprempeodnertstaiegldn.sattAutddyo,sdeossbeustascofoluolw2d.5asnmogt1/kbmegg//dkrgae/ypdeaaanytdedianbionovneea, sraetconpdremssteuadry significens of goresessdtiuafctiticioaontn.isoninwefreetaolb-sbeordvyedweiinghtrababnidtssiagndimfiinciasnttereidncrPeRaOSsesduriinngdelayed oplaecrvcteuslpIsantpiehoorfunmaaPblnFiOlSlbailnoodinondgme(anspnepabrum)apfllaecrstap,unogrpeiuP.nlFgaOtSIienomhnpatslshoeybieeUneensnittheeddeptaeStrcatttseedsp,eirnrmetihcelelntisoenbrluem(nbyopmf)sertuom LPaenmvd,elcswohmiielnrecaiiavnlertyhseousrmgacelenlserahslaavmepploepiunlodafitciacothnei,dldmrseeenarnuymhiaPeFvclOeoSdlelbdeelceeenvtveeledasns fhohrifioggmhh3eb0ria-gs4orde1sp3uoD.ine8.5sks wthiethnSaimtmpeeldainnSgtlaootfveaslsevhoeafsra5lshwpopiwbln.dlwiifdeespsrpeeacdiesdisftrroimbuativoanrieotfyBRoOfS.sitiensraecstroson,ss sanpaelcyiseess,ofPFeOagSlewsa,s also been detected dwienitledtchetbiezdpdpsbi,n ratanhngede pfiipsnbh.trhaenEgnedloigvieenrnsctuhseof pllueanvseemxlasposooeffd bsrerosustescensave u(sfeidshnienalt)o.xicity studies, presumably through a dietary sonces ppeorpsuilAsalttteihnoocnueg,haretthheelowbP,iFoOSathciclsuemvwuelilasdteisdvpeerteeapcodtteedpnrteiisnaelnt,chee,anbdlcoootmhdbeinoferedptrhwoeidtuhgcetntienvreealand eassdnuuvbbvescirthosarnneomcneeienscftf.ectcootnnstiicnoiunteypeotofoplbteeheparncodhdeumwciiecldad,ll,ifreerlaeoiavsseeersd,tciomnaecndersnahscocuulfmdourltaphteoetdecnhetiwnisaetlahle D. Exposure Data ptrhoeviAbdslionoigdndociflceaahtruendeavniisndeUannncdietwio1flV.dCwl.ii,fdeesPptFrhOerSaoduhgahseoxupbtoeseutnrheedetUtoencittteehedd has been in comercial use since the Sattatleonws levels in chemisal. PROS Csiontnagtiranec-atrseespaipasentradsn.toilOctohareterisnigsutsaepnsrtodlueccaotdasitnignognstofoa1neb9rn5iv0pci'assrp,,oenrmpCepranrertopddaeoultmcsit,nrsae,nlatenaldisyneclslieunadtishnoeglrsfwaaenmdd glfiEarereagteesfstitgvhpotolitunemgnetfiooafalnsP.FfOoSrThwpeirdovedasurpcirtoeiuaosdn shauunrmdfaancaereantdbreeelanitvemiverenodtnmufeesnetsparlessoemensxttpisotrasuhrcteseeunttohe shPaeRvvOSee.ralleSdtputodotieenstthieaazledeptuaentcdhtewiraowynasyoftthoaPtdFeOtmSearyinnianchecuomuatnnhteanfrdoorutaentshienaolwfideblexospopodrs.eeavedTheLemxragsocrmriece 11/8/2000 In