Document Ed5brabO25zzOJV3ov0211vag
E. I. du Pont de Nemours and Company Haskell Laboratory for Toxicology and Industrial Medicine
Elkton Road, Newark, Delaware 19711 HASKELL LABORATORY REPORT NO. 324-79
Material Tested*
Haskell. No.
Other Codes
Study Initiated/
Completed___
3/27-3/30/79
Material
'Jaqkaon Labor
EYE IRRITATION TEST IN RABBITS
Proceduret one-tenth milliliter of a 2% and a 0.2% solution of the test material in
into the right conjunctiva! sac of each of 2 albino rabbits. After 20 seconds, 1 tre washed with tap water for 1 minute. The treated eye of the other rabbit was not wash
of the cornea, iris and conjunctiva were made with a hand-slit lamp at 1 and 4 hours, 3 days; Fluor-i-strip stain and a biomicroacope were used at examinations after the
,
Results;
Solution
'
2%
,
;'
i
2%
; 0.2%
[ o.w
Dose
0.1 ml liquid
Treatment Not Washed
Cornea
None
0.1 ml liquid
0.1 ml
liquid
0,1 mi
liq'ad
Washed
Not Washed Washed
None None None
Ocular Effects
Iris
Conju
Very slight injection of
vessels 1-4 hrs.
Redness; Modera
sow..^mn^<t^:^^ None Discharge^ Mild a
at 4 hrs.
None
Redness s Mild 1
Swelling; None
Dischargei Mild 1
None
Rednessi None
Swellingi None
Dischargei None
None
Redness;
Swell ing:
None None
Discharget None
AR226-2880
I ; i. ''
r>A-->mri CinHI-m^ ("tiioc nr>* cnnl'li
fH-12.943^ whea tested aa a 2% solution in water caused a very sli
"and transient moderate conjunctival irritation with no come? 1 effects in |rabbit eye. In the washed eye a 2% solution caused transient mild conjuhctival irrita
)rneal or tri"tJic- a"f-f-e-c'-ts- . Both eyes were normal, within 1 day of treatment. A 0.2% s
in water caused no ocular effects in either treated rabbit eye.
,,
^------lia a moderate |to mild conjunctiva I irritant as a 2% solution 'in
|not an eya-Yrrl.tartt'^as a 0.2% solultion in water* Eye contact should be avoided. Flus
"-sontact should occur.
RLP/aph Report No. 324--/9 >ate Issued; August 24, 1979
Report by;
q^o^ c^O^^ //
Rayanne L. Perer
v
Toxicologist<^
Approved by;
0^^ ^ ^^--rr'-jf
'
,
Geefpcaalld'.t-iC.
Kenne
Chief, Acutfa investigatio
Company Sanitized. Does not con