Document E1ymbLzK1VMo6N7aeXae9bV

1 Alienee of Polychlorinated Biphenyl* In Human Milk and Serum (rom Texas and Human Milk from New Cuinea v fcy Paul C. Dyment, M.D., U. Col., MC ond Leon M. Hebc.tmn, M.D., Coli, MC TAi Miiifrfr 5*rvk*. WiUhm Bttmmeml CUotpifi, El Paae, fee. 79920 Eowarb D. Como And J. S. Wikmaw, PH.D. Cmawniiy /Valsrtfra Study titwiir/ 5n ImmAda Tee. R. W. Homnabiiook, M.D- F.R.A.C.P. , Inittlstp hr Hum** Bieiowy Territory / and /Vh AhM Polychlorinated biphenyl* (PCB'e) ere ohomloale used In induetry a^ plaetlelaere end in the manufacture of eleotrieel ineulatoft, varhletos, point*, lubricant*, heat tranefer ' fluid*, 4nd other produot*. Both PCB'e end DDE *fe apparently the moat abundant of the chlorinated hydrocarbon pollutant* In the cM**! eoceyeten (1). In general, the amount of PCB'e fora) in animal tleeuee tend* to parallel that of DDE, although the DDK/PCB ratio le loveet near Induetrial area*, aa fould be expected (2). Although PCB'e have been identified in fieh, wildliff, and the environment, their preeenoe ojr abeenoe in human tiaeue it virtually* unknown. Rlecbroudh, in a pereonal communication to the Ccevnlcelon on PteUaldee and Their Belationehip to Environmental Health li> 1949, Indicated that both pooled human milk and 9 individual human ad lk eaiqplo* from California were "poeitiva for PCB." (3) The purpoee of the preeent etudy le to investigate the degree of human contamination by PCB'e by .aeeaying human milk and eerun from an irtuetrial- lead eocleiy (Texae) and human milk from a, until recently, atone age culture (New Cuinea nativee). METHODS Seventy-nine lactatlng women were the eubjeot# of thle tudy. Thirty-two were from a variety of native village* In New Guinea', and 47 were from three eitiee in Texae: 24 from El Paio, a city with light induetry in a eemi-arid farming art ranching area; 16 were from McAllen, a email city In an agricultural area 1,000 adlee down the Rio Grande River from'El Paeo; and 7 were frem Koueton, a heavily Induetrialiecd city 300 adlee from McAllen. The El Paeo eaaplee ajeif* fro* U. S. Army eoldlera* wive* who characterietieally nave cone from all parte of the country, Breaet milk empire were, obtained by manual expreeelon into a ohomlcally clean glaee container and than kept froeen until , the time o^ aeeay. Twenty-eight eubjeote frem Texae bad ` Addreee foi1 reprlnte: Dr. Paul 0, Dysent, Cleveland Clinic Foundation,^ Cleveland, Ohio 44106 jf4 -I eeru art worn# repo chip extr to t ehro clca Anal ehro Colu w 10 eo/i eolu lay* act > >?* of r Inc* detet dete< art I othe: to U if tl they milk eucji poll* coot* had 1 Chios polli had detec MONS 064021 eerua eeaplM in* the iim dlnethed, the oilh na obtained, end this Mi, froeeo la glace until the tine of tatty, too tOMn toe hag heth tanai tad adlk eeoftlee ooseyed trt being reported oapmdely fa t study oonocrned with tho nUU hip Mtna) ferun tad allk Imit Of laoeodleldae (<). 2 al. palyles of blood aorga () tad all* (4) sen extracted *ldh hexane. Tha. blood extraod <ta oonocndnted do the da*load roluaa and injeetid lata lw iw-ltquU ' hronbtofraph (QIC); the adlk, hoaarar, oaadad Plorlell eloan-up prior do otaoondredion and Injection Into tba Old. Analyses tart toaoa|illalMd with t U^oroTak 220 (ta ohroaiadagraph, equipped with t tkldiue foil dadoodor. i Coluana uaad Wars l.Jg W-17 tad 1.92)1 QP-1 on Chrcaoaorb 100/120 aaafi H.P., and id SI-10 6d OP-1 on Chroouaorb V 10/100 aaah B.P, Tanpanturaa for tba 010 wtra at followsi saltan tar, 200 0; ialad dawn. 22J Cj dadaodor lap.' * C. Raoulta wtra aonflraad da conjunction with thlnItyar abroaddWapby. Theeo pardodtata of tha 0LC war# tad up to nab ua a oanoldlalty cf -1-ptrd par bllllen-of Id'-nt. Ido adaadard waa wda* aa than la a yarlady of POt'a aadllablo ta thla ootadry, oaoh too tUt Ida coat aaaaldlHjdy on tha OLC. MWft.18 MB , .. Daapldd tha dadaodlon of ahlorlaatad hydrooarben ... lneootloldec In all of tha Taxat oeaploe, no PCB'e won dtdaodod in either tha allk or tha oarun. Neither wan any Jdaotad la the allk froa Naa Outoea nadiras, although GOT and DDK wart dadoodad In all bud ona of than. Tha look of odhar lnaooiloldaa la thaaa laddar staples aaa ba adtrlbudad do dha omlyajlaa uoo of DOT la nalarla-eredloadlon prograad. eoauof PCI'a bra lipid aolubla wa could oaauao that If they worp Jpraoond in dho huaaa body la dodaodablo mounts, dhay aould ba raoovorad froa lipid aoadalnlnt dlaauo auah as odlk or saiun. Thalr dotal abaaooa froa thaaa staples would suggest that although peb'a an wldaapraod lnduatrial pollutants hr our oooayadan. they an nod pad algnlflaaadly aontanlnadlhK bunam. '' waaitOY Saranty-nlna loatortlag wonon froa Now Oulaoa aad Tons had Uioir bfoaod allk assayed far dha prooonoo of polyahlsrlMdad biphenyls (POg'a), a'widespread Induetrial ellutaad of jtho ococyodao. Tbaady-tlgM of those woooa I otrua ooofloo assayed far fOB'r also. Mo PCB'e won dodoodod to ofay of the ooaploo. I 4 MQNS Ar.KMOWLEparons DM authord wish to thank Dr. Reuben D. Wanda, Director Of tho Houston City Hsslth Deportment Laboratories and Dr. Janes W. OoUWs^l of MoAUsn, Texas, for obtaining some of the staples, (This resssroh was supported In part under Oontraot Ho. rn 86-6S-7J by the Pestloldes Coanunlty Studies Division, Pestloldes Offloe, Environmental Protsotlon Agsnoy, through the Texts State Department of Health. BtfflWMeas RISEBRCUOH, R. W., REIOKE, P., PMKWJ.. D. B., HERMN, S. 0., end DKVBI, tl. H., Nature 120,1098 (1968). PMXALL, D. B., and LINCER, J. L., Bio Solsnes 20,958 (iw>). : RISEBROUOH, R. W., In Report of the Secretary's Conmlaslon on Pestloldes and their Relationship to Environmental Health, 2)8, (1969), U. S. Dept, of Health Xduoatlon and Welfare. DOam, P, 6.. HEBERT80N, L. M., DECKER. W. J., OCNES, t. D., end fflSBMN, J. S., to be published. f. MU, W. CURLEY, A., end OUETO, C., Life Solanos 5,<7 (1966). 6. CURLEY, A,,1 and KMBROUOH, R., Aroh. Environ. Kith. 18, 156 (1967). i 0a4023 rtONS ) Tfc dlsldrl convert corraag photodl Isodris mors to the hoe noequit toxiclt of thel to mors hand, t rapid d Th isomers frashws cyclodi sent, t may eee food ch daterat Isomer* onset e related Result* metahol presentj Th purchs# were do animal* to di*t Pish, t suspena wsr# eo than 4 crudtec potrl d SalMaalb