Document Dvzw8dqRJq8r4nxmB5JbaDnOa

FoundM 1914 CHEMICAL SPECIALTIES MANUFACTURERS ASSOCIATION March 26, 1987 TO: FROM: CSMA Membership George G. Misko (y^? Regulatory Counsel ' RE: California Proposition 65: Lists of Covered Chemicals Suite 1120 1001 Connecticut Atf6n'cre,'NW1 Washington, DC 20036 APROu '87 202/872-8110 Pgr Proposition 65, enacted in California by referendum in November, 1986, prohibits the contamination of drinking water with chemicals known to cause cancer or reproductive toxicity, and require warnings prior to exposing any individuals to chemicals known to cause cancer or reproductive toxicity. The law requires the Governor of California to publish a list of those chemicals "known to the State to cause cancer or reproductive toxicity" by March 1, 1987. The chemicals on that list are those to which the drinking water prohibitions and warning requirements apply. On February 27, 1987, Governor Deukmejian published two lists of toxic chemicals. The first list of 29 chemicals are those which have been determined to cause cancer or reproductive toxicity. The second list of approximately 250 chemicals will be reviewed by a Scientific Advisory Panel established by the Governor. The decision to include these chemicals on the list of covered chemicals will be based upon the Scientific Panel's review. Copies of these two lists of chemicals are attached. Following publications of the two lists by the Governor, a number of environmental groups, among others, filed suit against the Governor. The suit generally alleges that the Governor did not include enough chemicals on the first list. CSMA also has available interpretive guidelines and procedures promulgated by the California Department of Health and Welfare. The interpretive guidelines provide definitions to many of the terms used in the Act. The procedures review the steps the Department of Health will take to make safe use determinations. If you desire copies of these documents, please contact Marlene Copeland, (202) 872-8110, at CSMA. ) We will keep you advised of other steps taken to implement Proposition 65. :mc vvv 000009022 CHEMICALS KNOWN TO CAUSE CANCER OR REPRODUCTIVE TOXICITY The Safe Drinking Water and Toxic Enforcement Act of 1986 requires the Governor to publish by March 1, 19S7 a list of those chemicals known to the State to cause cancer or reproductive toxicity. Health and Safety Code Section 25249.8(a). The attached list includes all those chemicals which are known to cause cancer in humans as determined by World Health Organizations International Agency for Research on Cancer (IARC) or the United States Public Health Service's National Toxicology Program (NTP). In addition, the list includes the three chemicals currently regulated by the United States Department of Labor's Occupational Safety and Health Administration (OSHA) as reproductive toxicants. The Safe Drinking Water and Toxic Enforcement Act of 1986 requires that the attached list be revised and republished at least once per year. Therefore, new chemicals may be added to the list based on the recommendations of the Safe Drinking Water and Toxic Enforcement Act Scientific Advisory Panel, changes to determinations of IARC or NTP, or changes to federal OSHA regulations. Questions about the list or requests for copies of the current list should be addressed to the State's lead agency for implementation of the Safe Drinking Water and Toxic Enforcement Act: State of California Health and Welfare Agency 1600 Ninth Street, Room 450 Sacramento, CA 95814 ooooo^o23 LIST OF CANDIDATE CHEMICALS The Safe Drinking Water and Enforcement Act of 1986 (the Act) requires the Governor to publish a list of chemicals known to the State to cause cancer or reproductive toxicity and to revise and republish the list in light of additional knowledge. A primary list of chemicals known to the State to cause cancer or reproductive toxicity has been published as required by the Act. However, it is also necessary to begin the process of considering additions to chis primary list. What follows is a list of candidate chemicals which is being referred to as the Safe Drinking Water and Toxic Enforcement Act Scientific Advisory Panel for its consideration and opinion. This list of candidate chemicals includes chemicals for which there is limited evidence of carcinogenicity in humans or sufficient evidence of carcinogenicity in experimental animals as identified by the World Health Organization's International Agency for Research on Cancer (IARC) or by the United States Public Health Service's National Toxicology Program (NTP). Under the terms of the Act, the Scientific Advisory Panel is responsible for reviewing the available data concerning these chemicals and any other chemicals which are suspected carcinogens or reproductive toxicants and forming an opinion on whether such chemicals have been clearly shown through scientifically valid testing according to generally accepted principles to cause cancer or reproductive toxicity. Any questions about this list of candidate chemicals or suggestions for additional chemicals to be considered by the Scientific Advisory Panel should be addressed to the lead agency for implementation of the Act: State of California Health and Welfare Agency 1600 Ninth Street, Room 450 Sacramento, CA 95814 VVV 000009024 Note: (1) An asterisk (*) indicates that the compound(s) responsible for the carcinogenic effect in humans cannot be specified. (2) The identification number is the Chemical Abstracts Service (CAS) Registry Number. No CAS number is given when several substances are presented as a single listing. CARCINOGENS Chemical CAS Number 4-Aminobiphenyl 92671 Analgesic mixtures containing phenacetin* Arsenic and arsenic compounds* ' - Asbestos 1332214 Azathioprine 446866 "'-'snzene 71432 Benzidine [and its salts] 92875 N,N-Bis (2-chloroethyl) -2-naphthylamine (Chlomapazine) 494031 Bis(chloromethyl)ether 542881 1,4-Butanedio1 dime thanesufonate (Myleran) 55981 Certain combined chemotherapy for lymphomas* Chlorambucil 305033 Chloromethyl methyl ether (technical grade) 107302 Chromium and certain chromium compounds* Coke oven emissions* Conjugated estrogens* VVV 000009025 -- Cyclophosphamide 50180 Diethylstilbestrol 56531 ilphalan 148823 Methoxsalen with ultraviolet A therapy (PUVA) 298817 Mustard Gas 505602 2- - 2-Naphythylamine Soots, tars and mineral oils* (mineral oils may vary in composition, particularly in relation to their content of carcinogenic polycyclic aromatic hydrocarbons) Thorium dioxide Treosulfan Vinyl chloride REPRODUCTIVE TOXICANTS 1,2,Dibromo-3-chloropropane Ethylene oxide Lead 91598 ----- 1314201 299752 75014 96128 75218 7439921 vvy 000009026 Candidate Chemical Carcinogens (Chemicals showing limited evidence for carcinogenicity in people and/or sufficient evidence in animals) Note: The identification number is the Chemical Abstracts Service (CAS) Registry Number. No CAS number is given when several substances are presented as a single listing. CAS Number 2-Acetylaminofluorene 53963 Aerylonitrile 107131 Actinomycins Adriamycin 23214928 AF-2;[2-(2-furyl)-3-(5-nitro-2-furyl]acrylamide 3688537 Aflatoxins -Aminoanthraquinone 117793 ortho-Aminoazotoluene 97563 1-Amino-2 -methylanthraquinone 82280 2 Amino- 5-(5-nitro-2-fury1) -1 # 3,4 -thiadiazole 712685 Amitrole 61825 ortho-Anisidine and ortho-Anisidine hydrochloride 90040 Aramite 140578 Auramine Azaserine 492808 115026 Benz[a]anthracene Benzo(b]fluoranthene Benzo[j J fluoranthene denzo[k]fluoranthene Bento{a]pyrene VVV 000009027 56553 205992 205823 207089 50328 2- - Benzotrichloride Benzyl violet 4B Beryl ore Beryllium Beryllium compounds: Beryllium aluminum alloy Beryllium chloride Beryllium fluoride Beryllium hydroxide Beryllium oxide Beryllium phosphate Beryllium sulfate Zinc beryllium silicate 2-(p-tert-Butylphenoxy) isopropyl-2-chloroethyl sulfite beta-Butyrolactone 98077 1694093 7440417 12770502 7787475 7787497 13327327 1304569 13598157 13510491 15191852 140578 3068880 Cadmium Cadmium compounds: Cadmium chloride Cadmium oxide Cadmium sulfate Cadmium sulfide Carbon tetrachloride Carrageenan (degraded) VVV 000009028 Chlordecone (Kepone) 1-(2-Chloroethyl)- 3-cyclohexyl-1-nitrosourea (CCNU) 7440439 10108642 1306190 10124364 1306236 56235 143500 13010474 \i Chloroform 4-Chloro -ortho-phenylenediaraine Citrus Red No. 2 para-Cresidine Cupferron Cycasin 3- - 67663 95830 6358538 120718 135206 14901087 Dacarbazine Daunoraycin DDT <1,1,l-Trichloro-2,2-bis(p-chlorophenyl)ethane N,N'-Diacetylbenzidine 2,4-Diaminoanisole sulfate 4,4'-Diaminodiphenyl ether 2,4'Diaminotoluene Dibenz[a,h]acridine Dibenz[a,j]acridine Dibenz [a,h]anthracene 7H-Dibenzo(c,gjcarbazole Dibenzo[a,e]pyrene Dibenzo(a,h}pyrene Dibenzo[a,i]pyrene Dibenzo[a,1]pyrene 1,2-Dibromo- 3-chloropropane 3,3'-Dichlorobenzidine (and its salts! 3,3'-Dichloro-4,4'-diaminodiphenyl ether Die poxybutane WV 000009029 4342034 20830813 50293 613354 39156417 101814 95807 226368 224420 53703 194592 192654 189640 189559 191300 96128 91941 28434868 1464535 4- - Di(2-ethylhexyl)phthalate 1,2-Diethylhydrazine Diethyl sulfate Dihydrosafrole Dihydroxymethylfuratrizine (Fanfuran S) 3- 3'-Dimethoxybenzidine (ortho-Dianiasidine) 4- Dimethylarainoazobenzene trans-2- [ (Dimethylamino)methylimino) -5- (2-5-nitro-2-furyl)vinyl] - 1,3,4-oxadiazole 3,3'Dimethylbenzidine (ortho-Tolldine) Dimethylcarbamoyl chloride 1.1 Dimethylhydrazine 1.2 Dimethylhydrazine Dimethyl sulfate 1,4-Dioxane Direct Black 38 (technical grade) Direct Blue 6 (technical grade) 117817 1615801 64675 94586 556127 119904 60117 55738540 119937 79447 57147 540738 77781 123911 1937377 2602462 Epichlorohydrin Estradiol 17B Estrone Ethinylestradiol Ethylene dibromide Ethylene dichloride Ethylene inline Ethylene oxide yVV 00000^ 106898 50282 53167 57636 106934 107062 151564 7521S Ethylene thiourea Ethyl methanesulfonate 5- - Formaldehyde Formylhydrazino) -4- (5-nitro-2-furyl)thiazole Glycialdehyde Gyromitrin (acetaldehyde me thyIformylhydrazone) Hexachlorobenzene Hexame thylphosphoramide drazine and hydrazine sulfate Hydrazobenzene Indeno[1,2,3-cd]pyrene Iron dextran complex Isosafrole Lasiocarpine Lead Lead compounds: Lead acetate Lead phosphate Lead subacetace ) Lindane and other hexachlorocyclohexane isomers 96457 62500 50000 3570750 765344 16568028 118741 680319 302012 122667 193395 9004664 120581 303344 7439921 301042 7446277 1335326 58899 VVV 00000^031 6- - Merphalan Mestranol 5-Methyl chrysene 2-Methylaziridine (ptopyleneimine) Methylazoxymethanol; methylozaoxyraethyl acetate 4,4'-Methylene bis(2-chloroaniline) (MBOCA) 4,4*-Methylene bis(2-methylaniline) 4,4'-Methylenedianiline and its dihydrochloride Methyl iodide Methyl methanesulfonate 2-Methyl-l-nitroanthraquinone (of uncertain purity) N-Methyl-N' -Nitro-N-nicrosoguanidine Methylthiouracil Metronidazole Michler's ketone Mirex Mitomycin C Monocrotaline 5- (Morpholinomethyl)-3-[(5-nitro-furfurylidene)-amino]- 2-oxalolidinone 531760 72333 3697243 75558 592621 101144 838880 101779 74884 66273 129157 70257 56042 443481 90948 2385855 50077 315220 139913 Nafenopin Nickel Nickel compounds: Nickel carbonyl Nickel carbonate 3771195 7440020 VVV 000009032 13463393 3333673 7- - Nickel hydroxide Nickel subsulfide Niridazole Nitrilotriacetic acid 4-Nitrobiphenyl 5-Nitro acenaph chene 5-Nitro-o-anisidine Nicrofert (technical grade) 1-[(5-Nitrofurfurylidene)-amino] -2-iraidazolidinone N- [4- (5-Nitro-2-furyl) -2-thiazolyl]acetamide Nitrogen mustard and its hydrochloride itrogen mustard N-oxide and its hydrochloride 2-Nitropropane N-Nitrosodi-n-butylaraine N- Nitrosodiethanolamine N-Nitrosodiethylamine N-Nitrosodimethylamine p-Nitrosodiphenylamine N-Nitrosodi-n-propylamine N-Nitroso-N-ethylurea N-Nitro s ome thyle thylamine N-Nitroso-N-methylurea N-Nitroso-N-methylurethane N-Nitrosomethylvinylamine > .<-Nitrosomorpholine N-Nitrosonornicotine VVV 000009033 12054487 12035722 61574 139139 92933 602879 99592 1836755 555840 531828 51752 302705 108032 924163 116547 55185 62759 156105 621647 759739 10595956 684935 615532 4549400 59892 16543558 N-Nitrosopiperidine N-Nitrosopyrrolidine N - N i tro s osarcosine 8- - 100754 930552 13256229 Orange Oil SS Oxymetho1one 2646175 434071 Phenacetin Phenazopyridlne and Its hydrochloride Phenoxybenzamine and its hydrochloride Phenytoin and sodium salt of phenytoin Polybrominated biphenyls Polychlorinated biphenyls Ponceau MX Ponceau 3R Procarbazine and its hydrochloride Progesterone 1,3-Propane sultone beta-Propiolactone Propylthiouracil 62442 136403 59861 57410 3761533 3564098 366701 57830 1120714 57578 51525 Reserpine 50555 Saccharin;sodium saccharin Safrole Selenium sulfide VVV OOOOO^G34 81072; 128449 94597 7488564 Sterigraatocystin Streptozotocin Sulfallate -9- Testosterone and its esters 2,3,7,8-Tetrachlorodibenzo-para-dioxin (TCDD) Thioacetamide 4,4'-Thiodianiline Thiourea Toluene diisocyanate ortho-Toluidine and its hydrochloride Joxaphene (polychorinated camphenes) 2,4,6-Trichlorophenol Tris(l-aziridinyl)phosphine sulfide (thiotepa) Tris(2,3 -dib romopropy1)phosphate Trp-P-1 (Tryptophan-P-1) Trp-P-2 (Tryptophan-P-2) Trypan Blue (commercial grade) Uracil mustard Urethane / 10048132 18883664 95067 58220 1746016 62555 139651 62566 584849 636215 8001352 88062 52244 126727 62450060 62450071 72571 66751 51796 VVV 000009035