Document DvmM4xXNzgKM0Og0QNR84DQdn
CONFIDENTIAL REGISTER OF CASES OF ANGIOSARCOMA OF THE LIVER DUE TO EXPOSURE TO VINYL CHLORIDE - REVIEW DATE 1 JANUARY 1988 PREFACE : ACKNOWLEDGMENTS, SIGNIFICANT CHANGES, COMMENTS AND REQUESTS
1 The 8 new cases in the Register are the following: Canada 11 and 12; France 22; Italy 06; Japan 03; UK 14; US *+0 and 4l.
1
2 There are amendments from the previous Register against the following cases: Japan 01 and 02.
3 I would like to thank the following for informing me of new cases: Dr Delorme, Dr Contassot, Dr Chiozzini, Dr Nakamura, Dr Evans, Dr Williams, Dr Dietz, and Professor Tamburro.
4 For the case corrections I thank Dr Nakamura.
5 It will be noted that there are gaps in our knowledge of several cases, notably Canada. 11 and 12 and US 4l. Also, so far as we know the following people are still alive: cases Canada 11, France 15 and 22, Germany 31 and 32, UK 14, US 33, 36, 4l. Is this correct? This is important information for the industry world-wide and we would appreciate news.
6 I should be glad if all recipients of the Register would continue to keep me fully informed of any new cases, or give the name and address of someone who can give me the necessary details. I have again attached a blank sheet at the back of the R gister so that information can be supplied under the appropriate headings, so far as possible.
7 As a result of the request sent with last year's Register, regarding Co-factors, we received a great deal ofinformation about PVC Plants, which has resulted^in many amendments to Tables 8, 9, 10 and 13. Further corrections will be appr dated, bearing in mind that the fables are confined to PVC.
8 RESEARCH: (a) May I again ask that all individuals involved in relevant research keep me informed and if possible send me reports. Perhaps recipients of this Register would pass on my request.
(b) Co-factors: In response to the questionnaire enclosed with the 198? Register, regarding possible co factors with Vinyl Chloride, I received replies from 26 Companies, covering 6l factories. This material is now being analysed by Professor Carlo Tamburro at the University of Louisville, Kentucky, USA, and we shall report on the results as soon as possible. We are extremely grateful to all who took the trouble to give this information. If any Company has not yet completed the Co-factor questionnaire I should be grateful if it could be completed and sent back to me as soon as possible.
9 I would also be glad of help to keep the mailing list correct and up to date, with news of retirements, etc.
FROM: Dr Brian Bennett, Occupational Health Department, ICI Chemicals and Polymers Limited Hillhouse Site, P 0 Box 4, Thornton-Cleveleys, Blackpool, FY5 4QD, England
February 1988
BB/BGS
008450
gemc
Index
Table Sequence
Belgium
Canada
Czechoslovakia
France
Germany
Italy
Japan
Norway
Sweden
UK
USA
Yugoslavia
Incidence of Cases per annum (Table 1)
Distribution of Cases
by Country
(Table 2)
Pattern of Cases by
Factory
(Table 3)
Latency Periods (Table 4A)
Distribution of Latency Periods (Tables 4R-4H)
Annual Geographical Incidence (Table 5)
ICI CHEMICALS & POLYMERS LIVER ANGIOSARCOMA CASES (REVIEW DATE - 1 JANUARY 1988)
WPX/ASO - LANGIOCASES,4
Page 1 2-3 A 5-9 10-15 16-17 18 19 20 21-24 25-32-' 33 34
35
36
ASL Case Numbers by year of Death (Table 6)
ASL Case Numbers by year of first exposure (Table 7)
Western Europe PVC Producers - Start-up Dates vs ASL Cases (Table 8)
USA PVC Producers - Start-up Dates vs ASL Cases (Table 9)
Canadian PVC Producers - Start-up Dates vs ASL Cases (Table 10)
East European PVC Producers - Start-up Dates vs ASL Cases (Table 11)
Japanese PVC Producers - Start-up Dates vs ASL Cases (Table 12)
South & Central American PVC Producers - Start-Up Dates (Table 13)
Australasian PVC Producers - Start-up Dates (Table 14)
Middle Eastern PVC Producers - Start-up Dates (Table 15)
Blank form for notifying new cases
Page 46 47 48-49 50-51 52 53 54 55 56 57
37 38-44
45
GENC 008451
LC.UM
TCI CHEMICALS A POLYMERS LIVER Angiosarcoma Cases - {Review Date : I January 1988)
WPX/ASL - LANC10CASES,6
HJ NTRY AND INFERENCE
NO
NAME OR INITIALS
DATE OF BIRTH
COMPANY
12
FIRST VC EXPOSURE
DATE OF DIAGNOSIS
ACE AT DIAGNOSIS
YEARS OF EXPOSURE TO
DIAGNOSIS
YEARS OF EXPOSURE
DATS OF DEATH
HISTOLOGICAL CONFIRMATION
ESTIMATED EXPOSURE
LEVEL
OCCUPATION
IS
OTHER CAREER HIGHLIGHTS
E6 I r J OTHER [ COW ENTS
________
12.01.13 Solvay
eppe 00.07.58 00.05.76
63
18
02 SR
29 09 40 Solvay
Jemeppe 20 08 62 00.10.79
39
17
29.06.76
23 10 83
Yes
High
Autocleaner
14 yra
1958-1968
exposed to Polyworker
200 ppm
3 yra
for hrs
per day
and
certainly
under
500 ppa
i n 6 to
9a3
autoclaves 1968-1972 exposed to 50-200 ppm 8 hra per day in 2 5TM 3
autoclaves 1972-1974
exposed to 50-200 ppa in autoclave room
1974-100 ppm
1975- 50
PP RETIRED
I Feb 1975
08.62-03. 63 01.67 -10.71 * 200 ppa 8h/day 04.61-12. 66 - 200 ppm
Au toeleaner 5 yra 5 mths Operator
yra 9mtha.
Driller in a foundry (2 yra) Pa mer (15 yra) Work in glass lnd. 6 chemi cal induetry
iHepstlc testa fin Oct 1974 |were normal. |Retired I Feb 1975 f Kospltallaed (May 1976
t fComplete iCllnlcal and Icareer details
|are given in a Ipaper by iHublet et al
tin Arch. Belg. | Med. Soc., iHyg. Med. ITrav, Med.
|L*K|1977 pagea
1601-622
_L
f
'1 reman since list algn July
0 71.
|79: Thoracic
J pain 07.79.
IHepatic tests
Isltered 10.79.
(Positive
lechography
111.79. Hepa-
Itectomy 02.80.
|Oieanr ha rspy.
11 rtf nrma t I on
tg I van In
lletter 12 Nov
11984 fro* Dr |De Sloover.
3 Re 2
ANADA heet 1
LIVER Angiosarcoma Cases - (Review Date: 1 Jan 1988)
DAY - MONTH - YEAH
WPX/ASiL - LAM>luCtlfe.a ,
10
12 13 14
15 1
16
COUNTRY AND REFERENCE NO
NAME OR INITIALS
DATE OF BIRTH
FACTORY SHAWINIGAN
FIRST VC EXPOSURE
DATE OF DIAGNOSIS
ACE AT DIAGNOSIS
TEARS OF EXPOSURE TO
DIAGNOSIS
YEARS OF EXPOSURE
DATE OF DEATH
HISTOLOGICAL CONFIRMATION
i ESTIMATED |
ii
| OTHER
| OTHER
EXPOSURE
|OCCUPATION 1 CAREER
| COMMENTS
LEVEL
|
) HIGHLIGHTS I
J_________________I___________________ !__________________
II
01 1
1
02 1 I l 1 1
03 1 1 1
! i 04 i i i i i i 05 ! I t 1 1 06 1 1 1 1 1 07 1 1 t
! I OB I l I l 09 t I 1 1
1 15.12.13 | 11
11 11 106.03.14 1
ft l1 11 ii 126.08.19 )
t1 11
11 11 105.04.19 (
11 11 11 11 ii 107.05.11 (
11
-
!I ii 1 15.12.19 | f1 11 11 11 109.11.19 1 11 1t 11
m.05.20 I
11 1! ii 119.07.21 1 11 11 11
1
i 1944 i 1955 i 41 1 1 1
1 J 1 102,09.55 |
1i
i
i
1
t 11
! !_ i i !
1 If
II
I1
! 11
i
1 1943
1957 I 43
1
14
1 14 121.12.57 |
i1 I1
11 1
1 r1 i ir
l1
-A
f
1 ij
i1
11
1 ii
i
1 1941
1962
42 1 21
l 20 123.03.62 f
I1
1 1 11
11
11
1 11
I
1
_L_
--I--.
____L-
1
J\
I1
1 11
!
1 1945 i 1967
48
22 1 22 F 2 1.01.68 j
1(
1 ft
1J
1 f1
11
t 11
11
1
! 11
it
l
t i 11
i
I 194^ ! I960
57 i 24
i 05 105.07.68 |
ii
i r 11
iI
1
i i 11
i ______ L_
|
i
iI
i
i
i
i I 1947 i 1971 i 51 i 24
1 1t i 11 i 23 110.04.7] |
tI
i
i
i
i 11
it
i
t
i
i 11
i L_ i
!
! 11
iI
t
1
I
I 11
t
i 1946 i 1972 f 53 i 26
I 25 (24.12.72 |
iI
i
1
I
i 11
It 1 i
t 11
iI
i
--1__
_J____
1
tt
iI
i
\
I
1 11
i
I 1961 t 1971 1 53
I
12
1)5 112.06.73 |
il
t
1
i
11
t1
i
f _J____ 1 1 1
ii 1 1
1 11
I 1946 i 1974 1 51 1 20
26 [04.09.74 [
ti 1 1
t1
(i 1 1
11
ii
1
1
____t___
!l
Yes Yes Yes Yea
Yes Ye. Ye. Yes Y*-k
f
fReactor
|Operator
|Smoker
1
Icleaner
lpolymerisation!
1
\1
r
|
|Maintenance ,|Operator
|Worked
1 lulllwrlght,
lovertlme
1 (pipefitter
|Smoker
11 f | I Operator,
1 |Worked
1
| foreman
i
1!
lovertlme 1 Non-smoker
1i
r
1
j
| React or
1 Ope rat or,
|Worked
1
Icleaner
1 foreman,
|overtlme
1i 1
1 water cooling |Smoker I uni t
1i
I
!1
1
1
1
(Reactor
JWater cooling |Worked
1
|cleaner
(unit
lovertlme
11
|Smoker
i1
1
t
t1
i
|
(Reactor
tMaintenance. (Worked
*
1
Icleaner
|ai llvrlRht
lovertime
1 1 | Smoker
11
1
1
11
1
1
|
1 Reactor
|Machine ahop (Worked
1
I cleaner
(operator and lovertlme
11
(poly unit
(Smoker
11
1
1
11
|
I Reactor
fMaintenance (In plant
1
Icleaner
Imachlne ahop |25 yrsl Smoker
1t
t
1
| iFurnace op.
1 I Worked
1 1 p1pef11 ter
(overtime
l |malntenance t
|Smoker
! ____________!_________________ ___________________ i .
'Ape r hy Dr f DF.I.IWME 1 n Anns led A ' Anatom I e put tiol ng I que Par I a , 1978 Vo 1 23 No 2 pp)05- 114 claim. thin case hatf both a hepatoma and ASL a I mu 11 anemia J y.
GENC 008453
-
age 3
]ANADA ;heet 2
ICI CHEMICALS f, POLYMERS LIVER Angiosarcoma Cases - (Revlev Date: 1 Jan 1988)
DAY - MOUTH - YEAR A]] daces use UK eyetea
VPX/ASL - LANGIOCASES.8
i 2 13
COUNTRY AND REFERENCE NO
NAME OR | DATE OF INITIALS | BIRTH
CANADA
ii
i
4 15| 6 1 7
_!L
L
11
1
1 1 FIRST VC 1 DATE OF
COMPANY | FACTORY | EXPOSURE I DIAGNOSIS
it
1
_JL II
ii
L 1
1
10
1 LG
_L 12 BC
t
116.05.15
125.10.13 Gulf
1
120.09.14 Culf
It II iI
JL 11 f Shawlnlgan
11 11 1\
JL l1 fShawlnlgan
ti 11 11
JL
1953
I 1976
1
1 1
t
1 Dec 85 1
1 1
L
i I Mar 82
i
i
1_L
8 AGE AT DIAGNOSIS
61
72
67
1 9 10 | 1J
1 12 | 13 1 14 (
15
I1
11
1
YEARS OF EXPOSURE TO
YEARS OF | DATE OF | HISTOLOGICAL | ESTIMATED
1
EXPOSURE | DEATH
CONFIRMATION | EXPOSURE J OCCUPATION 1
DIAGNOSIS
1
1 LEVEL
i
t1
1
11
OTHER CAREER HICHLICHTS
fI
1
23
14 100.04.77
Yea |
|Reactor
(Furnace op.
)
lcleaner
Imaintenance,
f1
lp.ck.glng
1 1 |7 Alive
1
1 Yea f
1!
1i
11
i1 1
1
(Mar 82
Yea
f
i1
11
1i
1L
1 1 16
1 1 OTHER f COMMENTS 1 I
f 1 Ex-smoker \ 1 \ i 1 Let ter from |Dr Fernand 1 Delorme, I Pathologist 1 1 (Letter from (Dr Fernand 1 Delorme, (Pathologist \
5
008454
Jage 4 ZE CHOSLOVAK1A
1C1 CHEMICALS 6 POLYMERS LIVES Angiosarcoma Cases - (Review Dale: I Jan S3)
WPX/ASL - LANCIOCASES >9
- 2 3A
COUNTRY AND REFERENCE NO
NAME OR INITIALS
DATE OF BIRTH
COMPANY
CZECHOSLOVAXIA
ni
28.06.18 State Co
02 06,07*27 State Co
57
FACTORY
FIRST VC EXPOSURE
DATE OF DIAGNOSIS
Novaky
01.07*57 24.12*71
Novaky
______________ Oi.U.50 27*11.64
8 AGE AT DIAGNOSIS
AS
37
9 YEARS OF EXPOSURE TO DIAGNOSIS
16
14
i1
i
10 1 n !L
l
12 i
__i
tI
I
YEARS OF 1 DATE OP f HISTOLOGICAL |
EXPOSURE } DEATH | CONFIRMATION 1
ii
|
1L 1f
1 1
11
1
ii
i
11 16 126.12.73 |
Yes
i t
11
i
1I
i
11
i
1t
iL
1!
15 I26.1L.64 |
Yea
i i 1 1
i . 1 14 1
1
1
ESTIMATED 1
(
EXPOSURE f OCCUPATION 1
LEVEL
1
(
15
OTHER CAREER HtCHLtCHTS
|Autoclave jCleaner
(Autoclave Cleaner
|IARC letter lof 1-4-82 Igtvlng detail a | Jfroa Prof (A David of (Centre Jnd (Hygiene and |Occ diseases*
r 1( 1IARC letter of 11-4-82 gave |somewhat faltered dates |for thla case. | have faccepted the Ichangea since |the dates cose Ifros Prof IA David of the ICentre of I Industrial |Hygiene and IOccupations 1
IDlseasea. My Idates cone (originally Ifros NTOSH.
I fI <11
If
*
1
f II
I III III
II If
JI
II
If
II
If II II
f I
|
f
I
f
I I I
16
OTHER COMMENTS
GENC 008455
4* 5
ANCE eet l
)UNTRY AND REFERENCE
NO
NAME OR INITIALS
DATE OF BIRTH
LANCE
15.04.24
SIM 03*06.11
NAV 06.01.20 04 27.01.27 PCUK
29.01.38
ICl CHEMICALS 6 POLYMERS LIVER Angiosarcoma Cases - (Review Date: 1 Jan 88)
WPX/ASL - LAHGI0CASES.I0
10
12 13 14
15
FACTORY
FIRST VC EXPOSURE
DATE OF DIAGNOSIS
ACE AT DIAGNOSIS
YEARS OF EXPOSURE TO
DIAGNOSIS
YEARS OF EXPOSURE
DATE OF DEATH
HISTOLOGICAL CONFIRMATION
ESTIMATED EXPOSURE
LEVEL
OCCUPATION
OTHER CAREER HIGHLIGHTS
16
OTHER COMMENTS
Rouaaillon
00.01*46 18.02.67
43
Brlgnoud 06*07.59 15.01,75
63
16
St Fons
00.00.46 15.01.75
55
29
Brlgnoud 19.10.49 16.01.76
49
26
Irlgnoud 18.01,65 13.05.76
38
19.02.67
12 24.01.75
Yea
(NIOSH no
29,06.75
26 04.01.76
Yea
3.05.76
High High High High
(Autoclave
t |Ref. Ravler ac
(worker and |cleaner
|al Arch. Hal. I Prof. 1 30 n'
119 yra
13 No* 75
IP 171-177
J__________
<2 jrra on
I
(Italian (origin
1
f Ref.
|C Bonne ton et
I 10 yra on
fal "Nowells
I polymerliaatlon
I I
Jpreaae laedlcale* 15 No* 1977 IP 735
j_________ X 1i
i
|Polyworker |VCM production!Ref. Rety et
110 yra aa I 16 yra
|a 1Arch. Kal.
lautoclave |Italian PCW IProf. I 37 n'
icleaner
JShepherd,
|6June 7?
{Compounding (Sawyer, Ha*on |p 551-555
13 pra
f
1
j___________ 1
(Monomer
I production
|worker
|3 yra
(PVC
I f 1 It rat Ion
118 yra
J_ _ _ _ _ _ _ _ _ _ _ _ _
High
|Polyworker 111 yra
GENC 008456
I1)Thoracotoay I Ref. P Coudere 19th Feb 1976 let al "Sewalne
(contal
(dee hoapltaux
Iangloaarcoma 110 Septeabre
|2) ScIntIgraphyl1976
(found ASL ,, |Previously had
I 3)Haemorrhage |bone
|frum ASL
|angloaarcoma"
|4}Rlg(it
|Alao
1 Hepatectony (I Prulllcithiiowakl et
M-La Nouvatle Msrtlrale
uly 1979
|Page 2485
;e 6
^,NCE *et 2
ICl CHEMICALS 6 POLYMERS LIVER Angiosarcoma Cases - (Review Date: l Jan 1938)
WPX/ASL - LANCIOCASES,!!
1 1t
J 1
AJNTRY AND |
IEFERENCE |
NO F
ANCE
1 1 f
21
HAKE OR 1 INITIALS |
3
DATE OF BERTH
i 4 15
_J 1 t
COMPANY |
i
i 1 f
FACTORY
1 6I
7
8
L _L
1
FIRST VC 1 DATE OF
ACE AT
EXPOSURE | DIAGNOSIS | DIAGNOSES
1
L 1
1
9 i
YEARS OF EXPOSURE TO I
DIAGNOSIS
i 10 i ii
i i
12
1L 11 YEARS OF | DATE OF 1 HISTOLOGICAL I
EXPOSURE f DEATH f CONFIRMATION |
11
iL 11 11
13 1 1
14
ESTIMATED EXPOSURE | OCCUPATION
LEVEL
i
t
i
1 1
( 1 I 1
t 15 1
1
OTHER CAREER HIGHLIGHTS
(* | |
r
16
OTHER COHHEKTS
06 [Pa 1 i i 1 I 1 i 1 1 1 1
07 | CIR
i i i 1
J 1
08 1 B l 1 1 1 i
j f
09 | RFX
i i 1 i i i i 1 i t t ! i
i 1 1 1 1 1
1 14.04.34 PCUK
|Brlgnoud 101.03.58 | L 2.08.76
42
18
1 3 Ml.09.76 |
Yea
Moderate 1(1958-1960) 1
11
KNIOSH |
12 <rrt
1
ii
Isays
1
)flltration 1
1i
112.09.76)1
110-11 yra 1
(TTila man had |AOL prior to I AS Ann. de 1 Mai. Prof.
11
11
|polyworker 1
I July *77
1i
11
land works 1
Ip 645 4 6.
1t
11
)lah?
1
JAOL vaa found
tt
11
f!
1 In 1971 flva
ii
11
i1
|yrs before
ii
11
i1
fASL
jL
!L
i1
1
l1
1\
f1
1
126.04.27 RP
(St Auban 01.07.50 | After
49
26
22 102.07.76 |
Yea
Ht|?h
(Plant fore- (1972-6 admin IDled of
i t death
i i (NIOSH no
| man In
(aectlon In
(septicaemia
i i N10SH
t i comment)
I polymer-
(St Auban
|Sm11 liver
1 1 says
11
1laatlon
1
(lesion found
i 00.07.76
1[
_1________________ 1
lafter autopsy
jL
1L
J_ _
I
1t
ii
101.04.34 Solvay
|Tavaux
23.05.57 | 03.L2.75
42
19
19 (30.01.77 |
Yes
Moderate |6 yrs packer!
(Had been
ii
11
autoclave 1
(tunnel worker
i1
11
|c Inr
1
IprevJouely
11
1
11
1 U yra
t
|
11
11
I autoclave (
|
11
1t
I worker
i
i
_L J _L L _L
11
1i
i
1I
11
11
1
(08.10.14 RP
| St Fons
10.01.48 | 26.04.76
63
28
28 125.12.77 |
Yea
Very High I Polymer-
(10 yra In
lOpersted 4.76
i1
it
1948-1966 I laatlon
leulphurlc
(for removal of
1i
ii
Leaser
(operator. lacld factory, 1 tumour from
ti
ti
Exposure (autocleaner (storekeeper & lllver and
ii
ii
1966-1976 |autoclave (Rener.l
Idled efter
i1
ii
| maintenance [services
|second
ii
11
11
Isurglcal
1f
f1
iI
(operation for
T1
ii
1(
Iblllo
i1
ii
i1
(bronchial
ii
ti
11
|fiatula
1t f1
ii ii
i| 11
|Paper by I Dr Ret y et al
11
11
11n Archive# da
1i ii
ii
1F
GENC 008457
'iLf'1'* ona a
ll Hit 6
1i
ii
1 I^ff5 papiaa
11 1 ___ _______ L
__ __ -
!1
1 t 74 1-1.
t'
age 7
RANGE iheet 3
ICI CHEMICALS A POLYMERS LIVER Angiosarcoma Cases (Review Date 1 Jan i 98fl)
VPX/ASL - LAMCIOCASES,I 2
t
12
13
J_____________ J___________ _L 1t
COUNTRY AND | NAME OR | DATE OF REFERENCE | INITIALS | BIRTH
NO
France
i 1
i 1
1 4 t5
1 1 1 COMPANY | FACTORY
1
_! 1 1
LO | VP
124.05.19 RP
|St Pons
1 I I i
i 1 IL
|
1
1 f 1
1 . .. .. 115.02.12
1
RP
i 1 1 1 1 \ St Feme
I
11 !1
i i
tt |J
I1 11
i i 1 1
11
t
i1
t
i1 11 1( i(
i i i i
t1 I1
i 1
1
J_____________ t
12 t
|16*08.14 PCUK
1t
1i
1 1Brtgnoud
i i
ii
j_____________ j__ _ ......
iI
13 i
119.01.11 Solvay
|Tavaux
i1
i
i1
1
11 i1
i i
11
r
11 11 t1
i i i i
j______________ 1
j
14 (MJ
105-04-24 Oi I oe
| St Fn n a
|1 11 Ii
Ch Iml e
1
{ Forme rt y 1
RP) i
1
11 f1
1 i
1______________ t
i
61 7
8
1 t FIRST VC |
DATE OF
______________j
ACE AT
|
EXPOSURE I DIAGNOSIS DIAGNOSIS |
1i
L _i
1! 1
00.12.S6 | 10.0L.7B
! SB
11 t1
i 1
1 ofi.6l.4i i 12.08.Ja
1 !
66 i
1!
1\ i
11
1i 1| 11
1\
1
11 t 1t
11
i
t r' \
1 1
A 1 I1
l
l ... .!
1 09.02.49 1 00.05.79 \
65
i
ii
ti
ii
3.09.63 ! 4.06.79 |
40
11
1t
t1 11
11
11 1F
!1
1943
i
i I D().07.81
!
1
57 1
1i
fI
i\
il
1It
1ii
9 YEARS OF EXPOSURE TO DIAGNOSIS t
21
30 16
3H 1 1 1 1 f
t1
JO t n
12 1 13 1 H J 15 J 16
_____t 1
YEARS OF |
EXPOSURE |
1 DATE OF J
DEATH
J_____________ 1 tJ HISTOLOGICAL | ESTIMATED f
CONFIRMATION | EXPOSURE 1
OCCUPATION
f 1 1 |
OTHER CAREER
i \ | OTHER 1 COMMENTS
1
| LEVEL J
| HIGHLIGHTS
1 _L 1
1 1
\i \
1
1r
1
21 110.OJ.78
i1
Yea
1 High |Autoclave 110 yrs In
| Died of
1
|
|cleaner
Imechanical
I pulmonary
1
11
(engineering |embolism 5
1
\t
|Induetry
Idaya aftar
1
!
[ 1946-1956
1 surgery
! 3 L I13.1I.7S
Yea
High
i j1941-1946
1 1
1
1
'
|polymer-
1
r
1
flsatlon
i
i
1
Igenera)
i
I
1
I purpose
S
i
t
|worker
i
i
J t1946-1972 1
1
f VCH
1
i
1
|ayathesla i
t
1
I(HC1 A
1
i
1
I Acetylene) t
\
\
J Foreman
i
i
)
K.genc
i
i
\
(de malt rise) |
i
1
11972
1
i
1
(retired
1
1 JJ
1 27 123.06.79
Yea
High
i JMonomer
1 1
i j
1
1product Ion i
1
1
(and polymer i
i
1
n! I 22.08.79
Yea
|1satlon
i
i
(operator
i
I Autocleaner (2 yrs aa cycle|Cigarette
1
II rr.
(mechanic.
Jemoker until
1
IAuto-
1 to yr. ..
11974. Ill .11
1
loperator
|ename tier In (of L977 due to
t
1
19 yr,
leanltery were (Oesophageal
1 1 |Copolymere (manufacture Ivarlcea.
1
1
19 yr
t
|Surgical
1
t1
1
(1nterventIon
1J
1|
i
125.05.79
1 i 1{right
1 36 f 29,07.fl]
i1
t
|hepatectoy)
Yea
j Very Nigh 11943-1975 11975-1979
1
F1
J I943-J975 IA 31 types oflmalntenance 1
1
I and
|)obn on
(work
I
1
i Jnt ermlft- Jmanufact ure |
\
1I F
I r nt t y
|6 maintenance
| 1975-1979 |tn VCM Poly
A
1
_j_____________ ---------------------l_i-
3458|Process
____
rfmTWo
Pa^e
6
FRANCE Sheet 4
TCI CHEMICALS & POLYMERS LIVER Angl osar coma Cases - (Review Date: 1 Jan 1988)
VPX/A9L - LAMClOCASES,13
to
12 13 [A
IS
16
COUNTRY AND REFERENCE NO
NAME OR INITIALS
DATE OF BIRTH
FACTORY
FIRST VC EXPOSURE
DATE OF DIAGNOSIS
ACE AT DIAGNOSIS
YEARS OF YEARS 0 EXPOSURE TO EXPOSUR
DIAGNOSIS
DATE OF DEATH
HISTOLOGICAL CONFIRMATION
ESTIMATED | EXPOSURE ( OCCUPATION
OTHER CAREER HIGHLIGHTS
.OTHER COMMENTS
France
1 1
15 |DEP
1 i !
i
1
_1 1
16 (GIN
i
1
11 11
i1 I1
1 1
103.01.37 1 Chloe
J St Pona
i
t Chlmle
|
i 1 (formerly f
i
1 RP>
1
i1
1
i1
__j i 113-07.22
Chloe
I 1 JSt Fons
1
1 Chlale
|
1 (Formerly |
1 RJ>) f
1 07,07.55 f28.09.62
ii 1
i! i1 l
|! 1I 1 17.10.41 | 05.01.83
ti ii 11
i t 1 1 j 1
| i i i i 1
45 6)
1
11
1
t
11
1
1 27
1 27 |Alive
1
(
if
1
1
i1
1
t
1i
1
1
f1
I
1
11
1
i
____ L_
1
1
i
ii
1
i 41
i 38 103.04 83 |
ti
1
i
i1
1
i
i1
1
Yes Ye
17 22.02.23 Chloe 17.06.48 03.04.83
Chlmle
(Formerly
RP)
34 26 03.04.63
1t
f
(Left Hepatectomy
1 1 |HIgh-2Q yr
(Moderate
1 f (Autoclave
(cleaner
t I |
f
11983
1J C Contasaot (Letter of
n yra F 1
|1955-1862 lautoclave (operator
I | |
15 10 1983
f 1
1 11962-1962 F
I1
1
11
1
|Hlgh-33 yrafPotymerlaat-I
\Moderate- Hon Process |
I Low - 5 yrs|Man
j
i 1 (Retired IJ.n 1979, |J C Contasaot
i
High 23 yre
ii
(Maintenance
I Worker
I
|Health &
(Safety Agent
J__________ I
tAutoclave
Other sectors
ICleaner
of St Fons
11948-1971
Factory 1971-
1976
(Letters of
rs io 1963 and
125 7 84.
r
t
I
fRetlred 101.01.79 |J C Contasaot I Letter of
IS 10 1983
14.07.42 SoLvay
Tavaux
09.09.63 21.03.84
42
21
21 27,12.84
21.03.84 Kigh-12 yra|Autoclave
i 109.03.84
Low - 9 yrsjClesner
IRlRht
IHepatectomy
(05.05.64-
124.09.84
Ichemotherapy
|for lung-
|ietastss(e -
I partial
f remission.
108.64 - Liver
I recurrence,
GENC 003459
lungi la^^Bon of | ttv^^ffseasa
j_____________
Page 9
FRANCE Sheet 5
1CI CHEMICALS 6 POLYMERS
LIVER Angiosarcoma Cases - {Review Date:
1
l Jan 1986)
VPX/ASL - LAHCIOCASESJ4
COUNTRY AND REFERENCE NO
FRANCE
19
20
22
NAME OR INITIALS
DATE OF BIRTH
COMPANY
FACTORY
FIRST VC EXPOSURE
DATE OF DIAGNOSIS
15.12.32
8rig noud 07.04.59 I 26.10,84
02.03.23 Atochem
Brlgnoud
1951
27.12.85
01.10.40
SEP Hontlucon
1959
03.06.86
AL
13.06.28 Atochea
St Auban 01.09.56 I 05.11.87
I
AGE AT DIAGNOSIS
10
XI 1
YEARS OF
| YEARS OF | OATS OF
EXPOSURE TO | EXPOSURE | DEATH
DIAGNOSIS
|
|
____________1__________ 1______ I
52 25 25 f06,11.85
1
63 34 22 126.J 2.85
45 27
128.06.86
59 29 26
HISTOLOGICAL CONFIRMATION
13 15 16
ESTIMATED EXPOSURE
LEVEL High
High
High
OCCUPATION
OTHER CAREER
OTHER COMMENTS
HIGHLIGHTS
Autoclave operator an< c leaner
X
(Hyocardlsl
11nfarctlon
Il980.Coronary (bypass 1981.
I Letter from
|Dr Contaeaot
Autoclave operator ant cleaner
15.4.86
J____________
In other parti 11 Portal
of factory
(fibrosis fro*
since 1946
126.04.74. The
llllneaa was
|diagnosed aa
(preswably
Iwork related
Ion 20.04.74.
1Letter from
IDr Contaaaoc
105.04,86
Autocleaner Maintenance
4 years
worker
J____________ t (Hepatic taat (Hay 84 normal.
IHepatlc teat
|Hay 86 showed
labnoraallelea.
(Letter from
|Dr Barrat
I 18.07.86.
J
High 1958-70
Low J 970-84
2 years Autoclave worker.
4 years In lontrot Rooa
(Letter from JDr Contaeaot, |Atochea 12.12.67
GEh 8460
age 10
GERMANY .heet L
1CI CHEMICALS 6 POLYMERS LIVER Angiosarcoma Cases - (Review Date: I Jan 1968)
VPX/ASL - LANCIOCASES 115
COUNTRY AND REFERENCE NO
NAME OR INITIALS
DATE OP BIRTH
COMPANY
10 12
14
FACTORY
FIRST VC EXPOSURE
DATE OF DIAGNOSIS
ACE AT DIAGNOSIS
YEARS OF EXPOSURE TO
DIAGNOSIS
YEARS OF EXPOSURE
DATE OF DEATH
HISTOLOGICAL CONFIRMATION
ESTIMATED EXPOSURE
LEVEL
OCCUPATION
15
OTHER CAREER HIGHLIGHTS
_L
i |
f
(
OTHER COMMENTS
01 00.00*30
00.00.31
03
00.00.30
12
04 00.00.30
OJ.10.56 19.09.66
38
23.OJ.69 Yea (NIOSH)
Pol/worker
14.10.57 25.09.70 09.06.52 00.03.73
39 43
13 21
J4.12.71 Yea (NIOSH) JO.10.73 Yea (NIOSH)
Polyworker
Filling pesticide aeroeol can with VC
_L
J (Reported under Inon polyner|latIon |workers In |NIOSH Hat of 01.3.77. IThla of courae |ls strictly (correct. |However 1 (wonder Ivhether this lean had high
Jexposure to 1VCH In his Jean filling foperetlonT
J_____________
16.04.57 26.11.74
17
17
25,11.74 Yes (NIOSH)
200-500 ppoi Polyworker 6 958 was
I Clinical
but high
temporary
autoelesner Idetalls in
uring l yr autocleaner for 5 yr
(paper by
autocleaner
ICokel et al
(Virchows Arch
1A Path 1976
(372 p 195-203
1
NC 008461
ERMANY heet 2
11
ICI CHEMICALS 6 POLYMERS LIVER Angiosarcoma Cases - (Review Date: l Jan 1988)
WPK/ASL - LAHCIOCASES,16
COUNTRY AND REFERENCE NO
NAME OR INITIALS
DATE OF BIRTH
05
Ai I OSH gives ia Case 06)
00.00.36
COMPANY
FACTORY
FIRST VC EXPOSURE
02*04.60
DATE OF DIAGNOSIS
10.12.73
ACE AT DIAGNOSIS
3B
YEARS OF EXPOSURE TO
DIAGNOSIS
10
YEARS OF EXPOSURE
DATE OF DEATH
12 13 14
_L
HISTOLOGICAL CONFIRMATION
ESTIMATED ] EXPOSURE | OCCUPATION
LEVEL |
______________ I________________
15 16
_L
OTHER
*1
CAREER
(
HIGHLIGHTS |
____________ L
OTHER COMMENTS
05 16.12.74 Yes (NIOSH)
I J6G Cheate | says |"chealstry 11aboratoria |ln the fTechno| logical |Research I Department" I(NIOSH says (assistant I factory (cheml at |which nay be Iwrong I translation!
t
|Conflrrned
I |Reported under inon-polymerIlaatIon Ivorkera In tNIOSH Hat of 131.3,77 and M . 78. E don't (think this ia |a correct Jclasalficatlon |by NIOSH. The lain may have Jbeen Involved tin VCM fpolymerisation |ln pilot plane |or In main Iplant.
06 NIOSH gives 9 Case 05)
07
00.00.32 00.00.26
00.00.17
16.12.62 00.00.75
43
15.04.54 12.11.75
13 09.01.75
21 (NIOSH
aaya 12)
11.11.75
19.07.54 06.04.75
58
20
20 25.12.75
Yes
(PVC - Manu facture IShlft Leader
J___________
| PVC Hami|facture and lall work find autofc leaning M2 yra 1(1954-66) I Foreman Tech (Dev 8 yrs 10967-1975)
J_____________
1 I Polyworker
08462
age
ERMANY hee t 3
12
:OUKTRY AND REFERENCE NO
NAME OR INITIALS
DATE OF BIRTH
09 00.00.34
10
NlOSH Rives as Case 11}
00.00.36
IIOSH gives ia Case LO)
12
00.00.29 00.00.38
ICt CHEMICALS 4 POLYMERS LIVER Anglosarcona Cases - {Review Date: 1 Jan 1908)
WPX/ASL - LANG IOCASE5
FACTORY
FIRST VC EXPOSURE
DATE OF DIAGNOSIS
20.02.61 16.06.76
01.01.61 00.01.77 10.10.55 28.06.77 00.00.61 00.10.77
ACE AT DIAGNOSIS
40 47 39
YEARS OF EXPOSURE TO
DIAGNOSIS
15
16
21
16
YEARS OF EXPOSURE
DATE OF DEATH
24.03.78
10 07.03.77 22 28.06.77
07.10.77
13
I
14
15
16
HISTOLOGICAL CONFIRMATION
ESTIMATED f EXPOSURE OCCUPATION
LEVEL |
__________ 1___________
I
OTHER CAREER HIGHLIGHTS
OTHER COMMENTS
High peaka 1 12 jrr. poljp-r |worker loci f
J1IX auto- |
(clave
)
(cleaning
|
(Control rooe|
1 l jrr 1
1 1
1|
t1 1| (10 yra poljr-|
{worker incl |
|171 auto(clave |cleaning
| t |
1r 1|
ii
High
ii
ii
(3 yrs auto- )
| clave
|
(cleaner
(
119 yr | filter
1 f
|operator
|
J________________ 1
Yea JPVC Menu-
(facture 1toe lave Iwocker for |6 yrs
110/78 I Confirmed (Average lexpoaure first |9 yrm 150 ppa. tocc 1000 ppa. (Next 3 yra ar, (75 ppw. Last. lyr tv 35 pp. t i (Average lexpoaure flret 19 yrt 150 pp.. |occ 1000 ppa. (Last yr av 17 5 ppw. CVH lletter of I21.0A.78 1
t T 1 i l
i
GEN^PS463
--
'#
13
GERMANY Sheet A
COUNTRY AND REFERENCE NO
NAME OR INITIALS
DATE 0? BIRTH
00.00.14
14
15
NIOSH gives his ns :ase 13)
00.00.29 00.00.23
ICI CHEMICALS f, POLYMERS LIVER Angiosarcoma Cases - (Review Date; 1 Jan 1988)
WTX/ASL - LANG IOCASKS,I 8
FACTORY
FIRST VC EXPOSURE
II
DATE OF DIAGNOSIS
ACE AT DIAGNOSIS
YEARS OP EXPOSURE TO
DIAGNOSIS
00.00.60 06.04.78
63
19.10.53 09.10.78
49
25
10.01.55
07,08,78 (Lelhach suspected ASL at Feb 1975 I aparotomy)
55
23
10 I 11
12 tr U
YEARS OF | DATE OF | HISTOLOGICAL EXPOSURE | DEATH | CONFIRMATION
II
Estimated
exposure
LEVEL
1 I
OCCUPATION
OTHER CAREER HIGHLIGHTS
OTHER COMMENTS
I 19.05.78 |
|Not an
|Angiosarcoma
I In his letter
Iof 21 12 81
|Mr Friedel
|said this vas
|a "Plattenepi-
|thelkarxinom
I Der
|Speiserohre"
l(a carcinoma
jof the
I oesophagus)
|not attribut-
lable to VCK 6
loot recognisei
fas an indust
rial disease
J_____________
25 123.10.78 |
Yes
If
1
20 107.00.78
Yea
I 1ASL and
I Hepatocellular
I Carcinoma
I I
Autoclave cleaner and vorker. Drier operator, ^ater shift
eader
High
Autoclave vorker til! 1964. Leader and master
GENC 008464
|F W Beat fletter of |30th June 1980 |enclosing data | f rom (Mr H P Frieda! |of BC Chemia__ \P V Beat I letter of |30th June 1980 feneloetng data I from 1H P Friedel of I BC Chemle |vlthdraving |thls case
I Angt onarooms |confIrmed 109/79. Some Idetall of this |A also cases |9, 13, 15, 16 |6 17 given In INRW Report for 11978 |Angiosarcoma Iconf1rmed, Ifull details Iof illness Itince March 11973 given In INRW Med Inap I Rep for 1978. |D1fferent {details given
#tn "VC oclated ease4* by barb and | Ms rat slier i / loan ,, i
14
:rmany leet 5
TCI CHEMICALS 6 POLYMERS LIVER Angiosarcoma Cases - (Review Dace: 1 Jen 1988)
WPX/ASL - LANCtOCASES,I 9
'.OUNTRY AND REFERENCE
NO
NAME OR INITIALS
DATE OF BIRTH
ERMANY
17 NIOSH gives s Case 15)
00.00.37
16
15"
20
2I
22
oo.oo.n
00.00.25 00.00.15
00.00.13
00.00.21
COMPANY
10
J 2 13 14
15
FACTORY
FIRST VC EXPOSURE
DATE OF DIAGNOSIS
AGE AT DIAGNOSIS
YEARS OF EXPOSURE TO
DIAGNOSIS
YEARS OF EXPOSURE
DATE OF | HISTOLOCICAL DEATH 1 CONFIRMATION
ESTIMATED EXPOSURE
LEVEL
OCCUPATION
OTHER CAREER HIGHLIGHTS
t |
| f
OTHER COMMENTS
01.11.61 14.08.76
41
<Jo.o6.t4 25.li.79
18.10.54 00.08.79
TT 5V
14.02.61 00.04.80
65
01.01.62
00.09.79 >rnnou need c 11 nlcfl I I ver s ymt oris)
I 5.10.61 2H.na.Ro
66 59
I 11 28.08.78 }
IT"
KTrrrr
25 18 22.02.80 I Yea |Metastaelng 1ASL 1
19 18
19 1
9.10.80 f
Yee
|Haenanglo
ISndothelloma
(of liver with
IHetaataaes
___________ I_____ _____________
9.06.80 I
Yea
| Ha ema ngl n
fRndntheIloma
lof 1tver with
| Met as trines
____________ 1__________
11 I06.12.B1 I
Yes
1
008465
| Met flat sh 1 ng IASI.
I__________
I
High
High High High lIlKh
Autoclave worker
Autoclave Worker
|Angiosarcoma |conf1 need. (Annual report |of the North |RhIne
|Westphalla
|Medical |Inspectorate I for 1978 (pages 347-377 Iglves full |detal Is. Vinyl (chloride |dlaesse Jdlagnosed 102-02-73.
| Oesophageal fvarices. |Radlologics11y (confirmed aero losteolyals.
lutoclave Worker
Autoclave Worker
iutoc lave Worker and worked In
rylng shop
| Dr Besche (letter of 113-04-82 to (Dr W C F Ada
_L I Dr Besche (letter of 113-04-82 to (Dr V C F Ada
l
J-
|Dr Beache 11et ter of 113-04-82 to I Dr W G F Ada
1
utoclave Worker
Chargehand, uhaequentIy foreman
*I Dr Beache nr -82 to 0 T Ads
ic 15
VtANY >et 6
ICt CHEMICALS 6 POLYMERS LIVER Angiosarcoma Cases ( Rev Date: 1 Jan 1988)
WPX/ASL - LANC10CASES.20
HJNTRY AND REFERENCE
NO SRHAHY
23
24 25
28
29 30
TT
NAME OR INITIALS
DATE OF
FIRST VC
BIRTH COMPANY FACTORY EXPOSURE
DATE OF DIAGNOSIS
00*00,27
1955
26.03.79
00.00.28 00.00.23 00.00.22 00.00.24 21.11.21
1969
1^60
11.10.82 2fl.09.~flT
1953
TOOT
nrrr
16.0K&]
01.10.60 LI.08.85
00.00.22 00,00,17 >0.00.23
Ao.nft. V)
1962 1951
953
TO-
I 5.02,83 07.01.80 10.06.85
00.n*.85
ACE AT DIAGNOSES
54
Sfl TT 55
62
TT
YEARS OF EXPOSURE TO
DIAGNOSIS
13 21
22
TfT
25
29 T?
Tfi"
10
YEARS OF EXPOSURE
DATE OF DEATH
29.09.SI
12 2fl.05.83 14.01.83
22 22.L1.82 02.03.8*
25 25.0fl.S5
5.02.84 25 5,05.83
70
I I VP
12 15 16
HISTO- 1
|
LOGICAL | ESTIMATED |
CONFIRW-I EXPOSURE | OCCUPATION
ATION | LEVEL |
J___________!__________ f
Yea |
High |Chemistry
IC*300 ppm) IWorker
E High |Autoclave
(<*300 ppn) ICleaner
fI
_L
I High |Polyclave
I |Worker end
J lAutoclave
| ICleaner
J__________ L
Yea |
High I Polyworker
High
-L I Autoclave 1 Cleaner till 11972
OTHER CAREER HIGHLIGHTS
OTHER COMMENTS
I Primary hepatocellar Icarctnoma; (proliferation of the (elnuaiodal cell* with (sinusoidal ectaala, \Friedel letter 23*12.86.
_L
{Prof Eder (Munich) (letter 22.08.03. fFHedel letter 19.04.85.
I
IProf Sel.,lr (Hunlch) Matter 22.OS.S3. I Friedel letter 19.0*.Si
_L |Chronic hepatitis, langlomatoais, sinusoidal (ectaala. Friedel letter (23.12.86.
JL
Lelbeeh. Friedel letter 19.04.65
High
I Process |worker 1947[84 <01.10.60 l-3l.03.fl4
IPVC productlion, [agitator (area).
GENC 008466
High
I
|Chemistry
|worker
_______ I_________
High |PolyworVer
I Shif t Ieader
(Annual VCH screening 124.04.85: no complaint. |no abnormality detected, f1970 two-thlrda Igastrectomy for ulcers. 11971 Coronary thrombosis |I983 Femoral |tmplantation |!9A4 Pulmonary embolism land pleuropneumonia. lLanders letters IS.09.65 land 04.02.87. J_________________________________ |Haemsnglosarkoma. IFrledeJ letter 23.12.86.
[Kaemanglosarkoma. |Friedel letter 21.12.86.
| Auf ni' [avr fr leaner
I [Pnlyworker |Autor1sve |c leaner
|Haemanglosarkoma, [Friedel Iet^^.21. I 7,06.
| llasmsng I nsa [Friedel letter 23.12.86,
Jaj?e
'TALY iheet 1
16
1CT CHEMICALS 6 POLYMERS LIVER Angloaarcona Cases - (Review Date: 1 Jan 1983)
VPX/ASL - LAHGIOCASES,2l
i
1
12
1
J__________ 1 11
OUNTRY AND | NAME OR | REFERENCE J INITIALS 1
NO 1
fALY
r i
3
DATE OF BIRTH
4 COMPANY
56
7
______________ _____________
FACTORY
FIRST VC EXPOSURE
DATE OF DIAGNOSIS
_____________
81
9
10 _________
li
AGE AT | DIAGNOSIS |
|
J
YEARS OF EXPOSURE TO
DIAGNOSIS
YEARS OF EXPOSURE
_________
DATE OF DEATH
_____________
Oi )n NtOSH stipplerentary lat)
) LG
02 1SE 03 | VC
04 | FB
f15,06,34 1
PANSAC
Mira Venice
00.00*65 19.04,71
36 | 06
1 I
1 1
1
( 1 113.lt *29
i
______________ ______________
Moncediaor Porto Hargheca
00.00.57
13.12.72
43 1 15
i 1 IJ 4.03,20
Solve?
Ferrara
______________ 00.01.53 10.07.75
55 | 22
i
1
1
1 A-
_j 1 120,07 * 3 7
ANIC
Ravenna
00.04,59 00.01.81
43 | 21
\\ 1
1
1
1T (
\\ f
1
03 16.04.71
_________ 06
_________ 21
_____________ 27.12.72
_____________ L0.07.75
21 10.03.81
|
ti
1
1
_J
11
n5
| G Darien In | 19,03* 17 PANSAC
Ml ra
_______
00.00.*7 07.03.S3
1 Venlce
1
1
1
_J_______ L
_______ L_______
46 1
16
_______ fl 06.04.83
__________
Si>< Mrt Itoiil ^ M Lavoro 63 f>w, 1974 Further letalIs In ftter from Or Hnntesano of 1ARC <
1 l lat 1982.
i1
(
1
12 1 13 1 14 1 i 5 1 16
! -1
1f HISTOLOGICAL ) ESTIMATED f
1 I
CONFIRMATION | EXPOSURE t OCCUPATION I
| LEVEL
1
J "1-----------------------------
OTHER
| OTHER
CAREER
1 COMMENTS
HIGHLIGHTS
7 Yea
1 1 1 1 r i i i
i
t l 1 |PVC Bag (extruder
1 1 ( t 1
1 {
f 1 | | 1 | t
1 f
iPrlaary tuaour Inay have been (perlcardlm. | No t botaoIgeneoua with lother caaea. [* **
Yee Yes
l i i
i i 1 High
t i
1i
1
1 Polyworker f
!
1 t
i1
1 Autocleaner l
18 yr ( 1953- I
161) Autoclave
1*
(
t
1972-5 did 1
a variety off
Jobs
|
* **
1
(operator
l Including t
i 112 yrs (1961 - PVC packing . |
i
(72)
i
i
1 11 Yea | L2 yrs - 11 yr - (Never cleaned f
1 Vry High IMonoaer
lautoclavea.
i 1 5 yrs ! Medina
loperetor 1 120 yra -
(See paper by i
**
ICHIAPPINO et |Non-aaoker.
|1 Med Lavoro f Co named
1 1 4 yra | Low r i i
i
IAutoclave IVol 6 (1982)
loperator & Ipp 555-563
lother dutleal
(In suapena- |
Jlon polywer- 1
llsatlon.
i
|Area Foreman
(little lalcohol. IA0L. 1 1
i 1
No
i |ln Bane Dept i lalnce (975*
1 i.
11
I
Yes I Medium-? 1 Bag extruderl
IHifth
11967-1975
1 |Conmercla]
1 |0ept 19761 1198}
1i
r
f t f
IS Psgll. (Lungs telex of
12 Aiift 1981 t 1
3 008467
A 1 H L> H `u Kftltmi Knd Rondlnella In Art a Onenlogir a Vnl
|9Hf natfOB 35 - 49
Page 17
ITALY Sheet 2
IC1 CHEMICALS & POLYMERS LIVER Angioaarcona Cases - (Review Date: I Jan 1988)
WPX/ASL - LAJ*C10CASE$,22
1
12
|
ii |\
COUNTRY AND 1 NAME OR |
REFERENCE | INITIALS)
NO i i
ITALY
JL
3
DATE OF BIRTH
1
* |
k COMPANY
1 s 16
7 1 8 t9
4 10 | 1 l
|
12 t 13 ! 14
1 >5 1
|
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|YEARS OF 1
4
i
ii
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|OTHER
|
i FACTORY 1 EXPOSURE DIAGNOSIS) DIAGNOSTSJTO
| EXPOSURE! DEATH |CONFIRMATION!EXPOSURE lOCCUPATION (CAREER
{
i1
r
|DlACNOSIS|
|
|
f LEVEL
|
|HIGHLIGHTS!
i J ! 1 ... . _J!L
1 11
11
J6 OTHER COMMENTS
Montedison |Porto
(01.10,60 |06.12*85 !
IKarghera,| 1 1
fVenlce | J 1
1111
| ! I1
14f1
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1 t 1 1
| PVC
f
|aanufacture|
1 11 years as)
|Autoclave |
(cLeaner
|
11960-71. f
J14 years Inj
IControt
|
|Room
f
11971-85
)
| Letters from Dr Chlotrlnl 1 22*09.87 and 1t.01.88
1 1 1 1 1 1 )
Venice,
1 }-
008^88
',e 18 JAN
ICI CHEMICALS 6 POLYMERS LIVER Anglosarcowa Cases - (Review Date: I Jan 1988)
VPX/ASL - LANCIOCASES.23
10
n 14
16
HJNTRY AND INFERENCE
HO
NAME OR INITIALS
DATE OF BIRTH
COMPANY
TosoJ1 Mori
01.08*22 Mitsui Toatau
FACTORY Nagoya
FIRST VC EXPOSURE
00.04.53
DATE OF DIAGNOSIS
24.10.75
AGE AT DIAGNOSIS
53
YEARS OF EXPOSURE TO
DIAGNOSIS
22
YEARS OF EXPOSURE
DATE OF DEATH
II HISTOLOGICAL | ESTIMATED I CONFIRMATION 1 EXPOSURE ( OCCUPATION
I LEVEL |
___________________!________________l________________
OTHER
I |
CAREER
|
HIGHLIGHTS I
___________ L
OTHER COMMENTS
13 24.10.75
I
I PVC Aaaoc M3 yra auto-
says not Iclave
known.
|cleaner
I * Japan
I 1964 -
f Tines
(assigned to
* 1ndlceted Id 1fferent
Ion 25. 10.751 work since
(exposures (had ill
(often at |health
| 3000 ppn up|
Ito 1974
|
| Japan Tines |25.10.75 i |Japanese PVC (Aaaoc letters (of 3L.03.7B 4 (30.11*87
(
1 02 |SC
1 1 1 t _i
03
?1
i
102.08.39 1Kanegafuchi|Osaka
1 |Chenleal |
1i
i
ii
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it
i
i J!
01.09.30 Mitsui Toatau
Nagoya
11 } 00.11.56 1
ri 11 11 1i
_____________ j
1 10.08.76 1
i 1 1 i
j___
37
i 1 i
_j____
17
00.07.65 26.06.85
54
20
1 1i 1 13 r io 08.76 | 1 ir 1 i1 i il t i1 i |1
14.09.85
t1
1
Yes |Not known |In polyner- |
1 llsstion work(
1 |Including (
1 jautoclave (
1
(cleaning
|
_J11--
High
|5 yeara |Autoclave (cleaner
I
(Japaneae PVC 1Asaoclatlon llettera of 131.03.78 t 130.11.87 1
(Letter Iron |Dr Nakaawra* IJapaneae PVC fAsaoclatlon I30.LL.87
In his letter of 1st April 1982, Dr Montesano of [ARC aays Japanese Ministry of Labour give
Date of diagnosis - 21-08-74 Age of diagnosis - 52 Years of exposure - 22
6ENC 00846
Re 19 RWAY
1CI CHEMICALS & POLYMERS LIVER Angiosarcoma Cases - (Review Date: l Jan I960)
VPX/ASL - LANCIOCASES.24
OUNTRY AND REFERENCE
NO
NAME OR INITIALS
DATE OF BIRTH
COMPANY
10 12 13 14
FACTORY
FIRST VC EXPOSURE
DATE OF DIAGNOSIS
AGE AT DIAGNOSIS
YEARS OP EXPOSURE TO
DIAGNOSIS
YEARS OF EXPOSURE
DATE OF DEATH
HISTOLOGICAL CONFIRMATION
ESTIMATED EXPOSURE
LEVEL
OCCUPATION
15
OTHER CAREER HIGHLIGHTS
_L l
|
| f
OTHER COWENTS
3RWAY Ot
i i
| AH 1 i 1 f 1 1 1 f 1 1 l t 1 1
f
it ii
123.12 15 | Norsk i 1 Hydro ii It 11 11 1t 11 i1 i1 1I 11 1i 11 11 ! ____ L
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22
i \1 i 11 1 11 1 21 104.01 .72 |
it 1 i1 i ii 1 11 i ii 1 i! i 11 i 11 i i1 i J1 i 11 f 11 1 t( 1 11
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fi
i
I
1i
i
1 | High
1 I Foreman 4
i |
f |Confirmed by
(Autoclave f
J Dr Thiis-
i (supervisor |
(Evansen of NH.
ii
i
|AC APHE Mtg of
ii
i
J9 June 1978
ii
i
(Hr P Rsngne*
i(
i
l.t.ted that AH
fi
i
] had been a
ii
i
(ember of s
ii
i
(starc-up Casa.
ii
|VCH 4 PVC were
ii
i
(made In same
t1
1
(building. The
fi
i
f VCH was made
ii
i
(from acetylene
i _JL__________________ i____________________
1
1 I
fI ri ri
ji
j
J
I
I
\
I
i f i
GENC 008470
,ge JEDEN
20
ICI CHEMICALS 6 POLYMERS LIVER Angiosarcoma Cases - (Revfew Date: l Jan 1988)
WPX/ASL - LAHGIDCASES,25
12
1! 13
4
1 I3| 6
i i
\ 7| 8
9
1 OUNTRY AND | REFERENCE |
1 1 MAKE OR |
INITIALS |
DATE OF BIRTH
NO i
WE.DEN
j_________
i i i
01 |NU
123.06.27
_____________ _JL i ii
i t i FIRST VC ( COMPANY | FACTORY | EXPOSURE
L
l
1 DATE OF
| DIAGNOSIS
1 1 | |
i
ii
i
i
_____________ i i
i i
L i
r1
ii
i
1
i 1 Kemsnord |SandavalI| 14.08.51 | 20.10.70 1
_L
ACE AT DIAGNOSIS
YEARS OF EXPOSURE TO
DIAGNOSIS
43 19
| i
02 |SL
i i IZ7.1I.11
_____________ _!L
1
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61
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i 110.06.10
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Kemsnord J Sundavall| 00.05.47
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r
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1 1 27 H6.08.72
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CONFIRMATION 1 EXPOSURE 1 OCCUPATION |
f LEVEL 1
I
ir i\
ii
15
OTHER CAREER HIGHLIGHTS
1 1 1
| 1 J
i i
L6
OTHER COWENTS
Yea Yea
Yea Yea
Yea
1 High
1
1 High 1 High
1 High | 6 Years
l Low -
| 10 Years
(Polyvorker |
t 1 1VCM
1 f |
production |
11 ii ri ii ir ii ii ii ii
ti ii
l
*
1Polywork.r
1
1
|1946-1958
i i
| 1
f
|
Jpolyaer-
|
llaatlon
|
lnork.r (12 |
1 yr) i 1958-1
|1977 foreaanf
1(19 yr) 1
|
|
11
11
11
Jl t|
t 1
f1964-1970
Icentrlfuge (operator 11970-1980 Idrter loperatnr
1
f
| | | | | | |
t
1 ]
|Hr SJoelln's fleeter of 128 March 1978 I confirms BL fwaa a khomt Ivorker who vat (heavily (exposed. (probably even |aore eo then (a normal (reactor (cleaner
1
r i
f
(In fIrat 12 lyr. of (employment had |been heavily lexpoeed. In 11974. liver Jabnoreality (and necrosis |d lagnosed. (Dsta confirmed |1n Dr D Byren (letter 18.8.77 1 to CEFIC 1
(Letter of 12nd Nov L961 (from |Dr David Byren
| f
GENC 008471
n hi* letter of 1st April 1982, Dr Monteaano of IAH.C says In Sweden's National fV>iirtl of US Health givea 20*02-70 as date of rllngnosls for Case 01 and 15-05-72 for Case 02
2
ee t
IC1 CHEMICALS 6 POLYMERS LIVER Angioaarcooa Cases - (Review Dace: I Jan 1968)
V7PX/ASL - LANGIOCASES ,26
'
1 HJNTRY AND j (EFERENCE |
NO | 1
i 2 13
L 1 NAME OR | DATE OF INITIALS ! BIRTH
1 1
OE |WJ 1 1 ! J 1 \
1 J 1 02 i ! t 1 03 | BJW
i i i 1 04 | JSR
i 1 I 1 1 1 1 i i 1 1 1 i 1 1
1 1 1 1 1 i J 1
120.04.01 1 1 1 1 1 1
1 1 1 1 1 1 1 (02.06.37
1 1
1 1 123.06.20 1 1 I 1 1 1 1 i 1 1 ( i i 1 (
1 1 1 1 1
1 1
t
iI
I
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i 5I 6
(
7
_L I
I COMPANY I FACTORY
L I I FIRST VC | EXPOSURE
L 1 | DATE OF
| DIAGNOSIS
l1
1
IL1
i 8|
9
ACE AT DIAGNOSIS
L 1 F YEARS OF | EXPOSURE TO
1 DIAGNOSIS 1
1 10 | 11
YEARS OF EXPOSURE
L l | DATE OF
| DEATH
*
L
12 13
HISTOLOGICAL CONFIRMATION
ESTIMATED EXPOSURE
LEVEL
___________________1________________ 1
t H1
1 1 1 OCCUPATION |
1 1
15
OTHER CAREER HIGHLIGHTS
It
OTHER COHHEKTS
ICI
BP ICI
|HILlhousel 04.04.44
11 t1 11
1f
11 t1
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fI II
11
!L i (Barry
i t 00.02.66
11
11
1 1 _______
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ii
11 ii (i i( ii I1
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03.12.72 ( Fox & Collier
| | 1
paper aaya|
23.12.72) |
1
1
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00,12,74
f
L
i |
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00.06.79
(
r 1 1 1 1 1 1 t 1 1 1 1 1 ( 1 1 1 1 1 i i i F
7
37 59
Ir
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28
| 22 (03.12.72 1
Yea
( 500 ppa | 1944-7 VCH |
1 I (Fox 4 |
t |1947-6 Drier|
1 (Collier |
11948-61
|
|Lee and Harry |Lancet (29-06074
1
1 paper
I
1 lAutoclave |
Ipagea 1316-8
r
Isays
|
i 123.(2.72)|
Joperator
1
i
$ 1961-66
|
1 I
i 11
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|
J lL__________________ i______________ ji
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124,12.74 |
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1 ii
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1 ii
i
1 (2.66 - 9.69
f ii
ii
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1 ii
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1
1(939-45 ary i
1 11
|
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i
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|
156-58
1 1945-54
1
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|
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|
156-61
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J
GENC 808472
te 22
ICI CHEMICALS & POLYMERS
VPX/ASL - LANCIOCASES.27
?et 2
LIVER AngioaarccMa Cases - (Review Deter ] Jan f988)
! 12 _i
!1 3 J ---------- 5-- 1 s
1t
1
8
1 ---------- 1-- --------- 5-------- ---------------- 5--------- t
10 i u
L _L i
i i
12 i n 1 14 1 __ i 1
UNTRY AND | NAME OR [ DATE OF |
1
FIRST VC ) DATE OF
ACE AT
YEARS OP 1 YEARS OF | DATE OF | HISTOLOGICAL | ESTIlttffll 1
EFERENCE | INITIALS | BIRTH | COMPANY 1 FACTORY J EXPOSURE 1 DIAGNOSIS | DIAGNOSIS EXPOSURE TO ) EXPOSURE | DEATH | CONFIRMATION | EXPOSURE I OCCUPATION 1
HO _j 1
i i _j
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1
ii 11
1 LEVEL 1 1
05 | JK
130.03.14 | BP
JBarry
08.01.51 1 00.10.79
65
2& * 2) 119.11.79 1
1 (1951-52
15 --f------------- rs-------------
OTHER CAREER
i | OTHER 1 COMMENT*
HIGHLIGHTS 1
1 i
1 ri 1 1! 1 11 1 11 1 11 1 1|
\ f)
1 1! f ir 1 it
1 ii I ii 1 i\
1 1 1 1 l r i t 1 1 1 f 1
1 11 1 11 1 11 I f1 1 11 1 ii 1 11 f t1 1 ii I ii i ii 1 ii
ii
1 1Polycleaner J 1 11952-55 1 f Latex ! 11955-60 1 j Polyfloor i 11960-64 1 IFoly f | Chargeh and 1 11964-70 t 1 Charging f foperator 1 |1970-72 t t Drier
i 1 1 1 1 1 F l 1 i i l 1
f ti
i
ii
1 loperator
1
! . .. 06 (CEP
I 1 1331
i | BP
_! 1 Barry
1962 I 09.01.80
48/9
________________ | 18 i
--.i
i
12 109.01.80 (
11 1 iTT^
1
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1 1|
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11
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1
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11
t (Operator
1
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f
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1f 126.6*.20 | BP
1 |8*rry
rws
j- 00.00.80
66
17
8.2
i, i ni.06.so i
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i IPoly Floor i (Polycteaner
i 1 1
i ii i 11
1 1
ii i t1
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f 1
i 1t
1
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1 11965-1971
f
i
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I
108.6s.24 1 BP ir
1 1 1 Barry
1
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19.63.50 I 2?.11.81
57
! ti
1 _i
i
31 i 24 125.12.81 |
i 11
1
11950-1956 1500 ppn
1
1 ii550-5i
JAutoclave
1 1
l Motor Mechanic!
l {i i ii / ii ) it l ii I ii t ij j tt
I 1!
i 41
1 1 I 1 1 1 1 1 J 1
1 11 i 11 I !1 t ii 1 it * ii 1 ii t ii 1 ii ( ii
J1968-1974 1200 ppa
i i 1 t t i i i
foperator 11951-1957 (CTtargeiaan (autoclave |bulldlng 11957-1974 JSMft (supervisor lautoclave (building -
1948-1950 Operator on Acetylene Production Plant
i i i i i i i i i i
1 1S I 11
1 1
1 11 1 ii
i INever i |cLeaned
i 1
f ii i i i ii
1 1 1
1 1I J 1I 1 ri
1 lautoc Laves 1 but
1 |aupervlor's
1 1 t
i if
1
l ii
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i
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f t)
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1 1F
1 Ithe*
_______ _________________ 1
i_______________ L.
l
j_________________
GENC 008473
23 ICT CHEMICALS 6 POLYMERS WPX/ASL - LAHCI0CA5ESj26
aet 3
LIVER Anglos&rcoata Cases - (Review bate: 1 Jan 1988)
1 12 131 A 1s
6I
7
8
9
t 10 i n
i
12 1 13 1 H 1
15
1
16
XINTRY AND | NAME --OR |1--DATME-- Ox P -i|
_] 1
JFIRST Vt
DATE OP
ACE AT
YEARS OP
i !1
J_____
1___
i YEARS OF | DATE OP 1 HISTOLOGICAL 1 ESTIMATED 1
1 1 OTHER
1 | OTHER
tEFERENCE | INITIALS I RIRTK | COMP AMY t FACTORY | EXPOSURE t DIAGNOSIS | DIAGNOSIS | EXPOSURE TO | EXPOSURE 1 DEATH f CONFIRMATION | EXPOSURE f OCCUPATION 1
CAREER
| COWENTS
NO
ii
_i
_L DIAGNOSIS X i i
| LEVEL i
| HIGHLIGHTS i *
11
i
i it
1
Ji
09 | EICP
107.05.25 I BP
1 Barry
15.02.50 | 02.03.83
58
33
i 29 124.02.83 1
Yes
| Med 1 ua I Polyworker (2 years on
ii
1
i )1
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11 11
1 1 *
i 11 1 11 1 11
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ll
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|
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10 1CJT
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27.04.66 J 01 05 8A
37
t 11
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i
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11
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1 1 Information
11
i
i 1j
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(vehicle drlver|glven In
11
i
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11etter
ri
i
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116,06*84 fro.
ii ii
1 i
11 ii
|(50 ppa). 168.
| Med 1 lib - |B1ow-down
I |
|Dr D J lUliliSM
ii ii
i i
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t |
1 1
if
i
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1
11968-70.
i
1
i\
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i
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1L 11 108.05.28 l BP
jX
X1
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19.12.65 | 02.06.85
57
19
i ii ii
1 16 102.06.85 1
Yes
(High
1i i
fPolycleaner
1 ILetter of
ii jt ii
1 1 1
1 11
i t1
1 1!
11965 -69 IMed 69-79 1 Low 79-82
11965-68. 1 Service (operator
i i 1
104.06.85 (Dr Paul Sal(h land letter of
ii 11 11 11 ii
1
1
1
1
l
i 11
1 11
i 11 i 11
i 11
I 168-69.
1 IPoly
1 (Operator
t 169-79.
1 1 Leading Hand)
104,06*85
}Dr D H D Evans
lOesophagesl
Jhae.orrhage
(due to
ii 11 ii t1
1
1
1
1
1 11
t 1f i !1 t 1f
1 179-82.
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12 1 JT
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11 124*01.37 1
11
11
f1 it
ii
ir
ii
ICl
J 11 |HI 1Ihouse{
1 11 t 1 i 1f I
16,09.57
L
1 03.06*85
1 48 28
i t1 1 11 1 28 106. 2*85 I I 1F 1 F1 1 ii i ii 1 ii 1 ii 1 it
Yes
i .... i
L t
I Low 1957-591Spare man.
I High 59-74
|Low 74-85 |
i
1 bagging
|floor 11957-59.
fAutoclave
I Operator
J 11959-85
1
| |
1 1
ILetter 126.06.85 (Or P I Lee
| |
GENC 003474
L______ _JL_
J
_JL_
J_ _ _ _ _ _ _ _ _ _ t
age 24
K beet 4
1C! CHEMICALS 6 POLYMERS LIVER Anglosarcoaa Cases - (Review Date r I January 198-0}
WPX/ASL2 - LANCtOCASES,0
'
COUNTRY AND REFERENCE
fQ
i 21 3
L
I
NAME OR I DATE OF INITIALS! BIRTH
1 L
i
4 i5 i t
6
ii 7 | 8 19
it | 10 I 11
1 1 12
!1
1 11 1 14
1 1 1L1 1 1
1
1 YEARS OP J
t
JHISTO- |
J
i i 15 l
i
i
1 1
1
t FIRST VC DATE OF | AGE AT 1 EXPOSURE | YEARS OF| DATE OF |LOGICAL JESTIMATED|
1 OTHER f
COMPANY i FACTORY EXPOSURE OlACNOSISIDIAGNOSISITO
| EXPOSUREI DEATH
i
1
1 DIAGNOSIS)
t
JCONFIRM-I EXPOSURE | OCCUPATION
IATION fLEVEL
(
1
i
CAREER
|
HIGHLIGHTS J
_L 1 r t L J1L
i!
16
OTHER COMMENTS
UK IMJ 102.03.48 (BP
|Barry
1 1968 1 Jan 86
37 1
18 1 3
102.06. 86 | Yea 1 High I Polycleaner
1 Moved to
)Remained well, working
n1
1
1
111
1
11
F1
11968-69
|Acrylonltrtle (actively, until Jan 1986
11 1
111
1
1F
1
| Low |Central
(Plant until
|
\1
1
l 1i
1 1 1 1 1 j Depot
Heft BP 1983. I
11
1
111
1
11
F1
11969-70
|Manager of
f
11
1
111
1
1F
1
F High 1 Polyfloor
|IC & SS Ltd at |
11
1
1 1f
t1
11
f1970-1971
|Cardiff Airport|
11
1
111
11
I1
11963-86
{
1 !1
11
1
14 IGS 113.06.42 IBP
i _J!
111
| Barry
107.07.66 127.08.87
!!
1 ___________
1
i !l 1i r
1
45 i 21 1 11 | Alive 1 Yea 110 aontha|Polycleaner 1
r I (Letters f row Or DMO Evsns,
ii
i
i11
i
1i
i
1 High
I 1966-67
1
|Pathologist, Penarth, Wales
1i
i
iii
i
ii
i
110 years 1 Polyfloor
1
land Dr U Ktlliw, BP, Barry
1i
i
i ii
i t i i Iconstant 1 worker at tiaea|
|
ii i 1 1i
i i
*
i i i ii 1ii
i 1 i 1 |Hed1m Ibetween 1
i
ii
i
fbut on t1968-1982
1
i 1 1 1 |inter-
1
i 1 i i Jaittent
1
1 1 1 i
1i
i
1ii
i
ii.
... 1
_ji
i i 1 i ijoba
... i
_! -J_____ ____ i
_j
1 --I1
1
GENC 008475
age
SA heet I
25
ICI CHEMICALS 6 POLYMERS LIVER Angiosarcoma Cases - (Review Date: 1 Jen 1988)
UK ayste* of dates DAY - MONTH - YEAR
WPX/ASL - LANCIOCASES.29
HJNTRY AND REFERENCE
NO
NAME OR INITIALS
DATE OF BIRTH
COMPANY
01 Earl
17.10.23 BFC
Parks
Louiaville
i 02 i
t
ii
1 19.08.33 1 BFC
!1
1 |Louia-
{ vllle
i 11 t 11
1 1
i 11
1 1\
03
|Edward
125.05.15 \ BFC
[Dinwiddle r
1
11
1
1
(Louis| vllle
1
1 )
04 i
JJ
1i
115.01.24 I BFC
_j
1
|Louis-
i 11
| vllle
i i 05 i i
J1
i1 12S.01.12 1 6FG
11
_! 1 |Louis-
I vllle
_j
i 06 |BY
|Austin
|Jones?
JJ
11 123. It, 28 1
11
11
BFC
_! l f Louis* 1 vllle
1
1 11 1 11
l 11
1
(
1
1 fJ
{ 11
07 |Charles t03.05.22 I ucc
|T Snart 1
i
_J
1
IS Charle-
| ston
r 1l
1
i
OH t
1l
I
[06.05.20 | Goodyear |HI agars
10 U
FIRST VC EXPOSURE
DATE OF DIAGNOSIS
AGE AT DIAGNOSIS
YEARS OF EXPOSURE TO
DIAGNOSIS
YEARS OF EXPOSURE
DATE OF DEATH
09.12.46 03.03.73
49
24
03.03.73
i1
15.11,55 t 00.05,70 I
37
1
14
i1
f
i
26.11.45 1 19.12.73
1 i i
s i
38
2fl
06.07.52 1
_1__ i
19.08.67 i
i
43
i
i
t
15
ii
it
19.06,49 [ 09.04.64 i
52
i
20
ii
_L_ i
i 1
17.01.62 1 00.02.74 i
45
1
12
i1
i1
i1
i1
i1
i1
tf
27.Ofl.44 f 00.00,68 1
45
1
24
11
11
07.10.46 r 00.OR,61
1 1
4
1
1 15
1 t1
{ 13 127.09.71 t
1 I(NIOSH }
1
{says
1
f 126.09.71)|
1 t . .1 1 11
1 28 | 19.12.73 | l {1 t 11
1 JI
J ii
1 15 107.01.68 |
l 11
1 11 1 11 1 20 109.04.64 | ( 11
1 tt
( 11 1 12 124,07.75 f
1 f1
1 11
l !1
t 11
1 ft
1 ii
it l E 7 S23.03.6fl 1
1l
f1
1l 15 129.08.61 I
12 n 14
15
16
HISTOLOGICAL CONFIRMATION
ESTIMATED EXPOSURE
LEVEL
_L
II | | OTHER
1 OCCUPATION 1
CAREER
I 1 HIGHLIGHTS
I I f | |
OTHER COMMENTS
_______________I__________________ !____________________ 1________________
fI
|
I {History Riven (Rolling Stone
1 |In AnneIs NY |Art
I Pot Cleaner (ACAD SCIENCES [Ref I NY Acad
I(Block Jams |Vol 329 (1979)[of Sc Syp
t 1974) p 53 }page 190 In |1974
I
|Paper by
{Also Block
f f B R Cot tine of|Jw* 1.7.74
I
|OSHA
|p 53
Yea Yes Yes Yea Yea
Yes Yen
ii
I
i
1 IPot Cleaner i
!<Cf Block) i
11
t
11
i
1!
t
1i
1
| IPot Cleaner |Louisville
1 l(Ct Block) I Courier
1 |Journal
1I
[02-09-80
11
i
| 1 Pot Cleaner
1 l(Cf Block) i
11
i
1t
i
| IPot Cleaner i
1 l(cf Block) i
1 ____________ L
i
IJ
i
[ JUS Air Force
11
i
J IPot Cleaner
1 f(Cf Block) i
1i
1
I
! |1
j i
f
1
iI
|1
i
JRef 1
|Also Bloc.
IJAHA 1.7.74
IP 53 1 i {Ref 1 |Aleo Block
J 1 [Ref 1 |Also Block 1 i lief 1 1 Also Block
1 1
(Ref 1 +
(Louisville
I Time* 23.7.75 [Ret 1 red Apr!1 | 1974
|Also Block t
1 Ref 1
1 1
| Ref 1
GENC 008476
26 et 2
ICC CHEMICALS 6 POLYMERS
LIVER Angiosarcoma Cases - (Review Date:
Jan I98fi)
UK system of dates DAY - MONTH - YEAR
VPX/ASL 2 - LANCIOCASE5J
10 12
14 15
16
IJNTRY AND EFERENCE
NO
NAME OR INITIALS
DATE OF BIRTH
COMPANY
FACTORY
FIRST VC EXPOSURE
DATE OF DIAGNOSIS
ACE AT DIAGNOSIS
YEARS OF EXPOSURE TO
DIAGNOSIS
YEARS OF EXPOSURE
DATE OF DEATH
HISTOLOGICAL CONFIRMATION
ESTIMATED EXPOSURE
LEVEL
OCCUPATION
09
Raymond
06.11,31
Gettle-
FI nge r?
Loulavllle
28.05.45 01.03.74
43
29
24 11.03.75
2000 ppm
in
16.08.13 Goodyear Niagara
12.06.51 00.05.68
55
17
17 10.05.66
27.05.09 Goodyear Niagara
14.10.46 00.03.70
61
23
23 16.03.70
OTHER
.1 OTHER
CAREER
| COMMENTS
HIGHLIGHTS I
J_________________
1
1
1 | Ref l has
|wrong flgura
|re first
lexpoaurt.
j Louisville
|Times
129.10.74 r
I 12.3,75.
I JO.3.76
J___________
I
f Ref 1
J_____
t
I Ref 1
1 i1
1*
i
1
)
12
|Francis a tn 11.18 ) Plreatone |Pottfttovn| 13,07 49 ! 02.0S.69 1
50
i
20
| Bachman i
t
1 Pa
|
t
l
i ti
ti
1i
1i
ii
1
1
i
i it
ii
1
1
i
1 i1
it
1
1
t
1 ii
ii
t
1
i
i ti
ii
1
1
i l. i ji 1 -J___
13
Richard
01.12.21 UCC
Edward
Clendentn
_L
$ Charle ston
II.12.42
00.05.74
52
32
14
11
11 1 1
15 1
11
!1 1 1
l !i
11 t 1
f 1!
i1 1 1
-1
\1
1i
i
1
1
1 11
1i
i
1
1
Ii 1 19 102 05.69 | 11 11
1 i1 1 it
t1 1 i1 1 i1 1 i1
26 07.04.74
Yes
11 I 1f 1 i1 1 f1 i 11 i 11
t 1 High
1 1 1 ! 1 1 1 t
1 I'O yr.MO yrs a.
1 (Utility 6
IRef 1 + letter
[reactor op. [Service op. lof 26 April
Knot cleaner!Bagger
11978 fro.
separate )Dryer op.
I Russel 1 A Park
Icrew cleaned|St ripping op. Ito J T Seaweti
fautoclevea) |3 yr* prior lof MCA
1
laervlce In
i
1
[tyre plant
i
!1
j____________________
2000 ppm
11
1
1
1 GENC 00847?
1
i
i , _J_________
ICharleston I Dally Mall 121.7.75
J__________ I {Never dlagInosed as angflosarcoma of lllver. Informlet Ion given In |1etter 22 Hay I 1964 from |J A SaIg.
I
|Accountant;
IASI, - No eviIdenra of VCH lexposur*.
__________
-c 3
ICI CHEMICALS 6 POLYMERS LIVER Angiosarcoma Cases - (Review Date: I Jan 1968)
UK System of dates DAY - MONTH - YEAR
WPX/ASL 2 - LAHCIOCASES.2
JNTRY AND "FERENCE
NO
NAME OR INITIALS
DATE OP BIRTH
COMPANY
10 12 13 2*
FACTORY
FIRST VC EXPOSURE
DATE OF DIAGNOSIS
ACE AT DIAGNOSIS
YEARS OP EXPOSURE TO
DIAGNOSIS
YEARS OF EXPOSURE
DATE OF DEATH
HISTOLOGICAL CONFIRMATION
ESTIMATED EXPOSURE
LEVEL
OCCUPATION
IS 16
OTHER CAREER HIGHLIGHTS
I r | |
OTHER COMMENTS
16 James 04.11.27 BFG Howard
Louis ville
08.05.50
41 J 9 04 27.03.69
1951-4 VCM polymer
From 1954 onwards In
(Table 4 In I Wagoner
isation
Army and other|Teetlmony to
service.
fUS Senate
46-50 Army
(Confirmed In
|M N Johnson
(Ur 07.08.78
17 Peerenbooa 06.05.31 BFC
Louis ville
23.06.55 11.10.74
43
19
16.10.80
Yes on I2.LO.74 but no post-mortem 26.10.80
____________ L
2 |Dr M N Johnson
lletter of 124.2.01 con
firmed death
f6 years after
(diagnosis
Chsrl le Arthur
22.04.28
Avon Lake 15.09.54 00.00.75
46
13 02.2 1.75
13 yrs
Navy
autocleaner
3 yrs on
Estol
Tyre Store
plasticiser
6 Carboset
ope rat ton
( |Confirmed In |H N Johnson Jler 07.08.78 (Also Rolling |Stone mag. 125.02.76
19
vi rgll
00.00.15 UCC
S Charle- 00.00.43 19.06.75
60
32
32 06.04.76
Christian
aton
20
31.08.17 Goodyear Niagara
00.00.55 30.01.76
58
21
IB 30.01.76
2000 ppm
J____________ I IWi11 lameport I Sun Cacette
(21 June 1975 |Charleston (Dally Hall
121.7.75
J___________
I INIOSH letter (of 25.10.79
j__________________
Chester
02,09.09 UCC
S Charle- 00.j 2,46 Marly 77
67
30
22 02.01.7 7
Yes
tinkle
H t Oil
|26 yrs with |UCC it SC |Ret 1 red |News release 123.2.77
GENC 008473
29 t5
IC1 CHEMICALS 6 POLYMERS
LIVER Anglosarcoaa Cases - (Review Date:
Jan 1988)
UK ays ten of date* DAY - MONTH - YEAR
WPX/A5L 2 - LANCIOCASES,4
t
L
12
|3
_] t NTRY AND | NAME OR | DATE OF
FERENCE | INITIALS | BIRTH
NO i i
i i
ii 26 tJohn Berry|07.07.23
1 (
1
1
1
t
i
1
1
1
1 f
i
27 |J L
111.05.16
|Forrest 1
1
1
i
i
i
26 i n.od.n
j__________ 25 112.t6.67
1
1
30 | WVN
|22.0}.i2
1 1 1 1 1 1
31 I0fl.ll.23 l 1 1 1 1 1 1
f
1 1 1 t 1
4 COMPANY BFG
UCC
UCC UCC
i
31
6
1 1 FIRST VC FACTORY | EXPOSURE
i
i
Loulavlile
i | 03.10.*7
|
i i i
i i 1
i 1
i
1
1
1
i
S Charle-| 01.07.4l ston |
1 1
i
i t
i S Charle-( 00.08.44
ston |
1 S Charle-| 00.05.42
ston f
i
7
DATE OF DIAGNOSIS
8
ACE AT DIAGNOSIS
00.00.77 (up to 2 years after death)
52 (death)
30.11.78
62
03.11.78
61
___________
00.03.80
72
Tenneco Chemicals
UCC
Flealngton 11.06.64 30.12.80 i i i 1 i i i _-r-rr
S Charle-| 12.05.46 01.08.81 ston |
i i 1 I ! 1
f
i 1
i
1 (
58 if
1 9 1 JO 1 U
YEARS OF
_J1 1 YEARS OF | DATE OP
EXPOSURE TO | EXPOSURE | DEATH
DIAGNOSIS i
1
1
t
28 f 18 111.02.75
(death)
1
1
1
t
t
1
1
1
1
1
1 1
1
f
if I 20 125.11.78
|(NIOSH
1
|aays 27 1
land C
f
|Dally Hall|
125)
1
t1
1 34 1 33 103.11.78
1
1 38 f 16 101.03.80
1 1
1 ' i? 1 1 15 (36.12.80
1
1
1 1
1
1
i 1 .x a 1 13 102.04.82
i
i
I
I
t
I
i
f
i
l i t
i
ii
i
12 t 13 1 14 | 15 1 16
I1 HISTOLOCICAL | ESTIMATEE J
1 f OTHER
1 1 OTHER
CONFIRMATION J EXPOSURE I OCCUPATION |
CAME*
( COMMENTS
1 LEVEL f
1 HIGHLIGHTS i
11
1
1i
r
Yes |Exposed In (Various JobsJ
i
i 1* gaalnakl
Iscee degree|ln PVC
J
Ito 22
[plants from |
(letter of (26/2/79 and
Ichealcats |cold rooa to|
|but aaln |paste
|
^exposure |recovery to |
|vaa to VCH ,|PVC charglngl
|(probably (operator to
thigh
Ipaste
|
I Prof. Teaburro lletter of 19/1/79
1 1 |
| {charging. 1
|
| (111 August |
|
|
11965.
1
1 (Terminated |
1 leaployaent |
1
| Jan 1966
|
|
J
1
1
Yes
1 High (Operator to (Exposure In (R N Wheeler
|
|L0.10.76
|bulk and
111 r of 4 Jan
||
Idlsperalon PVC(1979 and
||
laanufacture (Charleston
f1
1
|Dally Hall
|I 1t
J i
(30.11.78 and | R IUa inski
1 Yes
i 1
i 1
126/2/79 |R Kaalnakl
t1
1
11etter of
Yea
1 1 |
J
1 i (
t
1 i 1
i
J____
i .... ____i
Yes |6 - Uoknovn(Halntenance |
16/4/79 |R Kaalnekl fLettere of |19th June 1980 |4 5th Nov 1980
1
|9 - Mlnlsial(Mechanic i 16 yra 1 (Elsewhere
f I 1
1
i |
|
m yra
1
i |Boiler house!
i i
{Operator
I
i
i
\9 yra
|
i
Yes
{High (But (Chemical
|Froa (959 to |Dr Dacey
(not as MghJOperator In (1976 A! lphatlc) letter
|s reactor (charge
(Chealcala
)16.10.81 and
|c leaner
|reactor
loperator and (R N Wheeler
jwou)d
I
|fro July I976|letter of
(experience)l
Ito date
|9.lt.8U
|Worked as (
fForeaan
(Also Dr Dacey
|1abourer
j f FOfS
| |
lAllphattc |Chemical
lletter of 107.03.83 re
|June 1941 f
(Operation
Idate of death.
|tu Kay )946|
|
land may 1 have (c 1 eaned
I 1 i
1 1 i
GENC 0084?
et 6
30
ICI CHEMI CALS 4 POLYMERS LIVER Angiosarcoma Cases - (Review Date: l Jan 1988)
UK system of dates DAY - MONTH - YEAR
WPX/ASL 2 - LANCIOCASES,5
1 12
3 4 151 6
_____________
UNTRY AND | NAME OR EFERENCE | INITIALS
NO
DATS OF BIRTH
FIRST VC COMPANY | FACTORY 1 EXPOSURE
JL
US 32
|C W Giroux 22-02-08
Monsanto Springfield 13-10-51
1 Naas
|
7 DATE OF DIAGNOSIS
00-07-79`
i
t
JS 33
|S Fecgueon 08-10-27 1 Jnr
BFG
I Louisville 09-09-54
l1-05-82 S ''
tS 34
(Hr Byrvsi 29-01-34 RFC
JLouisville 1955
03-11-82
S 35 S 36
09-03-12 tree
|S Charle-I 23-07-44
(ston
|
ia-07-aa
27-08-32
The General Ashtab
'ire and
ULa
Rubber Co
1-06-56
J-08-83
i
8 ACE AT DIAGNOSIS
71
54 48 71 50
i 9 1 10 t u
YEARS OF
-J i !1
| TEARS OF | DATE OF
EXPOSURE TO ( EXPOSURE | DEATH
DIAGNOSIS
_________ j___________
28 1 14
i
i
i
117-05-80
1 (In PVC 1 (autoclave (
|area)
1
1
I
1
1
1
1
1
1
i
1
1
\
1
t
ji (
2& 1 28 1 Alive
i
t
i
i
ji i
27 1 to 104.08.83
1
(
1
1
1
J
1
39 1 14 118-07-83
1
J
1
J
27 Alive
ii
i
12 1 13 ( n i
( 15 1
16
1i
i
11
HISTOLOGICAL I estimated |
f
CONFIRMATION 1 EXPOSURE J OCCUPATION (
1 LEVEL i
i
1i
i
An autopay was done and Immediate
1i
i
|The death 11940-1951 1
(certificate!Various Jobs!
Ig.ve
Jin polymer (
cause of
|Hr Giroux' (manufacture (
death given (usual
1BUTVAR
|
aa loccupatlon ILUSTReX *Angiosarcoma | s "kettle)1951-1964
| I
(operator* (Various jobsf
1 In
|in and
|
j"cheatcal* |around PVC |
{Industcy". |autoclaves f
1 f1964-1973 |
|
I Various
J
|
(clerical
f
I (jobs In PVC |
> 1 polymerisation
I Ifacllity/ |
i
I Retired
|
OTHER CAREER H1CHL1CHTS
J ( OTHER ( COMMENTS f 1
I Information (given In (letter of 24 |February 1982 (fro. Dr 1 Wetter C | Barnet of |Moneento (Springfield to |Dr A Munn of IMonsanto J Eu rope. i f
1 | | |
Yea Yee
i 1
I 1 i i | i i 1 j 1 i t
101-03-73. 1
1 JMultiple 1 Jobs Itncludtng
| ) | |
1 Poly
1
I Operator \
1 Polycleaner.1
i 1 Poly (Operator + (Autoclere (Cleaner
i |1965 left 6PC (to become a IClergyuen. |
11955-65.
|
11
t 1 (Prof Tamburro (letter of M2 Aug 1982 + |Dr M N Johnson (letter of 128 Feb 1983.
1 |Dr M N Johneon (letter of 13 Mot 1982,
|2S Feb 1983 (and 9 Aug | (984.
!1
11
Yes (High fron 1
11944 to
1
11955.
t
I Medium trim
1 f | 1 1
r i (Dr Decey lletter of (5 Sept 1983. |
GENC
|1955-1958 !Moderate
008431
11 f 11956-56 I labourer 11956-57 fpTod helper IJ 957-70 (operator 11970-75 |e tect Helen |1975-present (operator
i I |R W Laundrie (letter of H2 Sept 1983: |spotted at (medical 1 May 19B3. (Teej |co^
r
u
at ?
ICI CHEMICALS 6 POLYMERS LIVER Angiosarcoma Casea * (Review Date; 1 January 1968}
WPX/A5L2 - LANGI0CASE5,6
UK system of dates DAY - MONTH - YEAR
INTRY AND NAME OR DATE OP
ERENCE
INITIALS BIRTH
COMPANY
37 Me J 29.08.29 8FG Payton
Louis ville
10
nM
15
IS
FIRST VC EXPOSURE
1953
YEARS OF
DATS OF ACE AT
EXPOSURE
DIAGNOSIS DIAGNOSIS TO
DIAGNOSI
06.08.84
54
31
YEARS OF DATE OF EXPOSURE DEATH
22 06.08.84
HISTO LOGICAL CONFIRM ATION
I ESTIMATED|
1 1OTHER
EXPOSURE 1 OCCUPATION |CAREER
LEVEL
(
|HIGHLIGHTS
J1L
t1
High |Worked
|
{regularly (
|in PVC area}
| In the
{early days
| waa a
f reactor
| cleaner
{1953-75.
OTHER COMMENTS
Information given In letter 09.08.84 From Dr N N Johnson
1 38 | JWB
jt f28.08.22|Mr
1 111 I Calvert 100.02.63 1 19.01 84 |
61
1
{
l Product# ICity
1
1
t
1 ii
1 1t1
1 ii
1 I1 1
t E1
111t
i ii
1 1)1
i ti
1t1 1
1 ii
t1 11
i ii
1 111
1 11 i
1 t 1 y--'* 1 1 11
111
1 11 1
1 ii
11 11
!ii
l 1 1t
1 ji
J J_______ J_____ !
iii
111t
39 |J Memlcel27.06.181Pantsaote IPaaaatc 1 I960 {March I 65
r ii
i
1
11984
1
1 l1 1
ii
i 20 | 20 1 28 10.83 | Yea | High (Normal
|
1 1 1 1 11963-J962{progreaalonj
( (1 1
{from helper)
1 11 1
(to aenlor I
! 11 1
loperator, |
1 1f 1
(cleaned
|
1 11 1
(reactors, {
t 11 f
(stripping |
1 1) 1
I and
|
1 11 1
(recovery (
1 11 1
(areas aa (
l 1t 1
Ivell ..
|
1 )1 1
|ch.rglnR |
1 11 t
loperator. (
(
t 1 24
( J__ I
.i
i.
i
11
i
ti
| 23 (29 06.64 | Yea { Low |29.09.60 - (Worked
1 l1 i
(May 66
|before
IThrombo cytopenia and leukopenia elnce
lattice 1978. Cold treatment for arthritis 11976. Under Dr*a care about 6 months Ibefore death, had paaaed standard physical (examination 3 months earlier, J Barr 1 letter, of 22.10.84 and 23.01.83. 1 1 1 1 1 1 1 1 1
1 (Never in hospital for any chronic or (acute medical problems. Death certificate latstea cause of death csrdlo-pulmonary
High
| Pabrlcatlon|with US
|Plant
| A1 r
| Ha y 66 - (Force,
|Aug 70
(United'
(Utility
f Wool
arreat secondary to angiosarcoma of : lver. Latter of 15.07.66 from John E Ertel of Pantaaote with letter of 24.02.66 from Or Auerbach, Pathologist.
| Ren 1 n
|Oyern
{Operator land
|(lnc Jul 66fCfcanite
{- Sep 67 (
I Reactor
J
{Operator) | Low |Sep /0-H7 (
{Monomer
|
|Operator |
Low j1962-83
|
| Ml I l
|
(Operntnr, |
iCaleiutnr ) |Shop, unt111
GENC 008482
1 retirement f
32
et e
1CI CHEMICALS 6 POLYMERS LIVER Anglosarcoaa Cases - (Review Date: I January 1988)
WPX/ASL2 - LANCIOCASES,7
UK. system of date* DAY - MONTH - YEAR
l1
! il
1
12 |
31
4 1 5 16
1 7 1 8 |9
i 10 1 11
I 13
| ]4
11 1 13 1
16
JL 11
UMTRY AMD |NAME OR 1 DATE OF)
FERENCE \1NITIALSI BIRTH |
11
J 1
1 COMPANY |
i
JJ
1i
)FIRST VC f DATE OF
|AGE AT
1 |YEARS OF
1 EXPOSURE
FACTORY |EXPOSURE |DIAGNOSIS!DIAGNOSIS!TO
ii
|DIAGNOSIS
1
YEARS OF| EXPOSURE!
DATE OF DEATH
1 |HISTO-
1
|LOGICAL | ESTIMATED!
|CONFIRM- (EXPOSURE fOCCUPATION
|ATION )LEVEL
|
11
it
|OTHER
1
(CAREER
1
[HICHLICHTSI
OTHER COMMENTS
A 40
JL 1f
L
|P P
| 26.10.L 41 BFG
(Gilmer |
i ij
1I1
1
|Louis* | 22*05.42 l 1987 1 72 1 45
(villa
1
i
1
34 I03.01.B7 | Yes 1
il
(l | High IChenlcal |I942-1974|Worker
1!
...
(1
1 1 Letter froa Dr Diets, BFG,
1 110*3.87
t1
it\
i
1
1 1942-45
i
i
11
t 1i
t
1 Low |
11
ii
i ii
i
1
1 1975-19761 Fomin
(
)
11
1 ii
1
1
fl945-76
1
1
JL
II
J ij
1 11
j 1 j i____________!________________ 1
1 1j
1
t 1
4 1 |R Buckley ? 1915 | Goodyear IN1agars IT late | 1987 1 72 | 7 40+ ) 7 30 I Alive | 7 Yes
it
i 1 1940'. !
.pprox |
i
t
1 1 Letter fro* Prof Ta*burro i lUnlverslty of Louisville
ii ii
t11 / 1t
ii
I
t
fi
i1
i1
it
i ) 1 t ii1
i1
JL_______ L
j____________ J
J
1
j
1 j___________ _____________i__________ J________ i
,e 33 OSLAVIA
ICI CHRHICALS & POLYMERS LIVER Angiosarcoma Cases (Review Date: I Jan 1968)
WPX/ASL - LAfHJIOCASES,]]
J
jntry and
-'EftENCE
2f
3i
1 __L
11
NAME OR | DATE GF(
INITIALSI BIRTH i
1i
L __L
4 COMPANY
1 5f 6 ( 7 1 8 19
J 10 t
1 1L 1 1 1 1
l 1t
1
JYEARS OF |
1
3 (FIRST VC| DATE OF | AGE AT |EXPOSURE ? YEARS OF|
| FACTORY|EXPOSURE J DIAGNOSIS|DIAGNOSES!TO
| EXPOSURE|
i ii
t (DIAGNOSIS!
Li
i i.
1
1
i i
1]
DATE OP DEATH
1 17
tn
i
U
11 |HISTO-
l
(LOGICAL (ESTIMATED!
|CONFIRM-| EXPOSURE f OCCUPATION
|ATION (LEVEL
|
t
| 15 1
OTHER | CAREER
HIGHLIGHT ______________1
'SLAV1A
16 COMMENTS
05.04*14 Jugo Vinil
Spilt
00.00.53 08,04.73
59
20
20 06.04.73
Yes
/ ISAR1C at al paper (Env Health Perspective Vol 7. Ipp 189-192 1976
15.11,31 Jugo Vinil
Split
00.00.50 12.07.73
42
12.07.73
VCM Production
*ln his letter of 3 Oct 1970. Or Splrtaa of NIOSH changed the status of Case 02 to VCM production eaplojree. Or Splrtaa also notified a new Case .03 also a VCM production worker.
11.06.30 Jugo Vinil
Split
15.12.58 03.09.78
48
Rosa Kanlnaki latter of 19 June I960 and IARC letter of 1 April 1962
i 1
G1 003484
Page
34
TABLE
1
(Review Date - 1 Jan 1988)
Incidence of ASL Cases Per Annum
By date of death
1955 .................................................................................
1
60
7 .......................................................................................... 1
8 ......................................................................................... 0
90
1960 .............................................................................................0
1 ......................................... ............................................... 1
2 ........................................................... 1
3 ..................................................
0
4 .......................................................................................... 2
5 .......................................................................................... 0
6......................................................................................... 0
7 ..........................................
1
8 .......................................................................................... 5
9 .......................................................................................... 3
1970 .......................................................................................... 2
1 .......................................................................................... 3 2 .......................................................................................... 5
3 .......................................................................................... 8
4 .......................................................................................... 5
5 ....................................................................................................................
,H
6 .....................................................................................11
7 ................................................
9
8 ........................................................................................ 10
95
1980 ...................
10
1 ......................................................................................... 5
2 .........................................................................
3
3 .......................................................................................... 10 4 ......................................................................................... 7
5 ......................................................................................... 6
6 ......................................................................................... 3
7 ........................................................................................._1_
Total
129
N. B-. ' 1 Does not include Italian 01 but does include German 03.
2 The 1977 total includes US case 24 which is a Cholangiosarcoma. 3 not include the following who are still alive, 6o^ as known:
Canll, Frl 5 & 7 2. OH s. ***> uvj/,
GENC 008435 non 'i C t
Page
35
Distribution of ASL Cases by Country
TABLE
2
(Review Date - 1 Jan 1988)
USA W Germany France UK Canada Sweden Italy Yugoslavia Japan Czechoslovakia Belgium Norway
Total
38 *** 31 ** *** 22 *** 13 *** 12 ***
5 **** 5* 4 ***** .3 2 2 1
138
* Omit ItOl - atypical case of PVC bag extruder. ** Includes G03 aerosol can filler.
*** Includes case US 24 which was diagnosed as Cholangiosarcoma; & Canl!, Frl5 & 22, G31 & 32, UK14, US33, 36 & 41 who are still alive, so far as known.
**** Includes one monomer worker. ***** Includes two monomer workers.
i.e Western Europe . . North America Rest of World
79 50
9
Total 138
'X/ASL2 LATJnTOCASES.lO
008486
i'age 36 Pattern of ASL Cases by Factory
TABLE 3
(Review Date - 1 Jan 1988)
(a) W Europe
Of the 79 cases in W Europe, 68 have occurred in clusters at 12 factories. Of the 31 German cases, 28 have occurred in clusters at 4 factories.
ASL Cases
Dynamit, Troisdorf, Germany BP, Barry, UK Wacker, Burghausen, Germany Atochem (formerly Chloe Chimie, formerly RP), St Fons, France PCUK, Brignoud, France Kemanord, Sundsvall, Sweden CWH, Marl, Germany ICI, Hillhouse, UK Solvay, Tavaux, France Lonza, Waldshut, Germany Solvay, Jemeppe, Belgium Atochem, St Auban, France
12 10
9
8
7 5 4 3 3 3 2 2 68
NB: There are 32 pre 1962 PVC plants in W Europe; 18 of these have had ASL cases (Ref Table 8)
(b) N America
Of the 50 cases in N America, 42 have occurred at four factories out of a total of 55 factories. In N America 43 plants have not had ASL cases.
ASL Cases
BFG, Louisville, US BFG, Shawinigan, Canada UCC, S Charleston, US Goodyear, Niagara Falls,
US
15
12
10 _5 42
NB: There are 29 pre 1962 PVC plants in N America; 12 of these have had ASL cases (Ref Tables 9 & 10)
(c) Rest of World
.The 9 ASL cases are believed to be in one cluster of 4 and two clusters of 2 cases. WPX/ASL2 - ^blOCASES,!!
6ENC O084S7
'age 37
TABLE AA
(Review Date - 1 Jan 1988)
Latency Periods (Years from first Exposure to Diagnosis)
W Europe America
Country Belgium France Germany Italy Norway Sweden UK
No of Cases
2 22
31 5
1
5 13 79
Total Years 35
57A 632
99
22 122
293 1777
Average 17.5 26.09 * 20.38 * 19.8
22
24.5 22.53 * 22.49
?st of World
US Canada
37 955 25.81 *
10 205 20.5 * 47 1160 24.68 N America Average
mma EL
Czechoslovakia Japan Yugoslavia
W Europe N America
2
3 A 9
79 A7
30 59 85 174
1777 1160
15.0
19.66
21.2
19.33
Rest of World Average
22.49 24.68
Rest of World
9 135
174 3111
19.33 23.04 *
GENC 008483
^ countries with > io cases, France, and USA have an average latency period above world average; Germany, UK and Cj
he low worMlj^fcyerage.
Does no
lude Canll or 12, or US41: details not known.
m
da
DISTRIBUTION OF LATENCY PERIODS TABLE 4B
(Review Date - 1 Jan 1988)
Belgium
1 1 1 1 1 1 1
Canada **
i
Czechoslovakia
France
Germany Italy Japan Norway Sweden UK USA ** Yugoslavia
TOTAL **
1 1
1 1 11 1
1I
1 1 1 1 1
1 1
1 1 1
1
1
1
0-9 yrs |
1
1
1
1 11 1
!
1
1 1
1 1 11
i
1
i
11
i
1
i
1
1|
1 1
i i i i ii i
i i 10-14 yrs 1
1
1
1
1
1F 3I
\ 1|
r 1(
1
5| 1l i il i ll
1
l
i I
1
1
2t
i i i i 12 I
1
15-19 yrs |
21
1| 4I 91
21
1|
21
5| 7|
33 |
1
1
20-24 yrs |
1
1
1
i
11
5|
1 1
1
3I I
10* | i1
2I 1I
21
If 1|
f
1
1 11
F 91
i 4I
1
1
37 |
1
25-29 yrs
1 1 1 1 1 1
!
2
8
5
1
11
F
1 1P
1
l
21
r 4I
1
8I i i i i
30 i i
30-34 yrs
1 1 1 1 1 1 1
3
2
1
1 1 1
t
11 1
2l
1
51
1 1 1 1
13 1
1
1
! 35+ yrs |
1 1 1 1
\1
1 1
1 1 1 1
|I
1
\
1 11
I |
1 1 1 F 1
i i i i 9I
Total
2 10
2 22
31 5 3
1
5 13 37
4
135
11
I Average |
| Latency | I Period | KTable 4A)|
11
1 17.5 | P1
1 20.5 |
ff 1 15.0 | \1 1 26.09 |
1l 1 20.38 | t1
1 19.8 | 1|
1 19.66 |
ii ir
1 22 1
| |
1 24.5 |
FF 1 22,53 1
FF
1 25.81 |
11
1 21.2 |
11
1) 1 23.04 |
11
* Includes G 03 aerosol can filler
<* Does' not include Canll or 12, or USA1: details not known
GENC 008489
'X/ASL2' - LANtIOCASES,t3
TABLE AC
Page 39 (Review date 1 January 1988)
LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE
MAX POSSIBLE 1
YEAR OF
1
LATENCY PERIOD | FIRST EXPOSURE 1
LATENCY PERIOD (NO OF YEARS)
| ARITHMETIC MEAN
1
1 OF LATENCY PERIODS I
11
A8
I 1939
1 38*
47
| 1940
1
46 | 1 1 37,21,37,41
45 1 2 t 32,38,45
44 1 3 1 38,14,32
11
|1
1
289 = 36.12
1
|8
|
|1
lI
1
4
1 28,11,24,20,24,34,39 |
718
26.59 |
I 5 I 27,22,28,29
1 27
1
1 6 1 21,29,31,26,28,15,23,1
1
1 30,35
|
40 | 7 I 29,24,29,28
I
39 1 8 1 28,24,34
|
1
I
1 1
1 9 1 30,26,20
| 521 = 24.80 1
1 1950
1 26,22,31,19,23,14,33 1
21
1
I
1
1 19,28,17,28,34,29
|
1
35 1 2 1 21**,15
|
34 1 3 1 25,22,23,22,20,31,22,1
1
I
1
1 32***
|
1
1 4 1 21,21,25,25,21,28***,|
1
1 1 22
| 787
22.48 1
1
5
1 22,23,24,14,19,21,27 |
"35
1
1
1 27*** 24,28,30***
|
I
1 6 1 21,12,27***
|
1
30
I
7
1 19,17,15,13,16,28
|
29 1 8 I 18,18,15,17,20,29*** |
1 1
19 I 1960
1 16,21,25,27 1 13,18,21,25,24,25
| |
544 = 18.75 1 29 1
1 1 1 15,16,16,16,19,19,12 I
1
25
1
2
1 13,18,17,12,18,21
|
24 1 3 1 16,17,20,21
|
1 1
1 4 1 16,17
|
221
= 17.0
1
1 5 1 11,19,20
| 13
1
1 6 1 9,18,21*** v |
|
20 I 7 1 16
V
1
1
19 I 8 1 18
i
1
1 9 1 13
1 1970 ti
1 1
15 1 2 1 14 1 3 1
1 41
I TOTAL
1 135 CASES
|
31 = 15.5
1
12
1 VIOLA
11
11
1 1 MALTONI
1 1 GOODRICH | 3111 = 23.04 1
11
1 135
1
* Cholangiosarcoma ** Aerosol can filler
*** The following are still alive, so far as known Frl5 and 22, G31 and 32, UK1A, US33 and 36
NB: Does not include Canl1 or 12, US41: details not known
GENC 0QS49Q
TABLE AD
Page 40 (Review date 1 January 1988)
latency periods of asl cases tabulated by year of first exposure AND GEOGRAPHTCAT
LOCATION
' ---------------------- -
MAX POSSIBLE 1
YEAR OF
1
LATENCY PERIOD I FIRST EXPOSURE I
LATENCY PERIODS IN
WESTERN EUROPE 1
NORTH AMERICA
1
48 1 47 1 46 1
45 1 44 1
1939 1940
1 2
3
1 1 1
1 37,41
1
1 38
! 1 38*
1
| 21,37
1 32,38,45 | 14,32
1 4 1 28 1 5 1 27
| 11,24,20,24,34,39 | 22,28,29
I 40 1
39 1
6 1 21,29,31,33 7 1 29 8 1 28,34
| 26,28,15,23,30,35 | 24,29,28 | 24
1 9 1 30,26
| 20
1
1950
1 26,22,31
l 19
1
35 1 34 1
1 1 19,28,34,29, 2 1 21** 3 1 25,22,22,32***
| 17,28 | 15
1 23,31
1
4 1 21,21,25,25
1 21,28***
I 5 1 22,23,24,27***24,281 14,19,21,27
1
| 30***
|
1
30 1 29 1
I
6 1 21,12
7 1 19,17,15,13,28 8 1 18,18,29*** 9 1 16,21,25,27,
l 27***
1
| 15 |
1
1960
1 13,18,21,25,25
1 24
1
25 1 24 1
1 1 15,16,16,16,19,19 | 12
2 1 13,18,17,18,21
| 12
3 1 16,17,21
| 20
1 4 1 16
| 17
1 5 1 11,19
|
1
6 1 9,18,21***
I
20 1
19 1
7 1 16 8 1 18
| |
1
9 1 13
vl
1 VIOLA 1970
11
12
1 MALTONI 3 1 TOTAL CASES
1 1
.1
1 79
1
|
1
| 47
* Cholangiosarcoma ** Aerosol can filler
*** The following are still alive, so far as known Frl5 and 22, G31 and 32 UK14, US33 and 36
| ROW
1
|
1
| | I
1 1
I
1
| | 1 23,14 |
1
1 22,20
! 22 |
1
1
1 16 1 17,20 | | I
1
| |
1 20
|
1
I |
1
1 1
1
19
NB: Does not include Canll or 12, or US41: details not known
WPX/ASL2 - LANGIOCASES, 15
6ENC 008491
TABLE 4E
Page 41 (Review date 1 January 1988)
PLANT
START UP DATE
LATENCY PERIODS OF ASL CASES IN SPECIFIC PLANTS (10 OR MORE CASES)
NO OF |
AVERAGE
CASES | LATENCY PERIOI
LOUISVILLE USA
TROISDORF W GERMANY
SHAWINIGAN CANADA
S CHARLESTON USA
BARRY UK
| 1940? |
1
1
I 1954
1
1
|
11
I1 I 1943 | I (1941?) |
11
I 1939? |
1
l! | 1948
1
i
1
|
11
12,14,15,19,19,20,24 ,27,28,28,28,29,29 31,45 12,13,16,16,18,19,19 ,21,23,25,28,29
11,12,14,21,22,23,24 ,24,26,28
24,30,32,32,34,35,37 ,38,38,39,
9,17,18,28,31,33,18, 19,18,21
1 1 1 1 1 1 1 1 1 1 1 1 1
15 1
1 1
12 |
1 1
10 |
1 1
10 |
1 1
10 |
24.53 ye* 19.91 20.5 33.99
21.20
NB: Does not include cases Canl1 and 12 at Shawinigan: details not known
WPX/ASL2 - LANGIOCASES,16
SEWC 008492
Page 42
TABLE 4F
(Review date l January 1988)
LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPECIFIC PLANT (IQ OR MORE CASES)
YEAR OF FIRST |
EXPOSURE
|
1939 1940
1 1
11
21
31 4|
5I
61
71
8
9 1950
1 I 1
11
2I 31 4|
51
61
71
81
9 1960
1 1
11
21
31 41 51
61
71
81
9
1970
1
11
21
LOUISVILLE|
USA
|
1 1 1
20
28,29,27
29,28 24
19
15 31 28 14,19
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
1 1 12 1 1 1 1 1 1 1 1 1 1 1
TROISDORF W GERMANY
29 21,25 23,28
12
13
16,16,19,19, 18
I SHAWINIGAN 1
1 CANADA
1
11
11
1 21
I 1 14 1 11,24 I 22 1 26,28 1 24
1
1
1
1 1
I
1 1 1
| |
11
11
1
1 23
1 1
11
11
11
11
1| ||
II
1 12
1
1I
11
1|
11
11
1!
11
II
|
1V 1
11
S CHARLESTON I
USA
1
38 |
37 32,38 32 24,34,39
|
1 1 1
I
30,35
1 1
BARRY UK
1
I
|
1 31,33 1 28
1
| | | |
1 1
| | I
1 18 1 17
1
1 19 1 9,18,21
1
1 18 I
|
1
1
NB: Does not include cases Canll and 12 at Shawinigan: details not known
WPX/ASL2 - LANGIOCASES,17
GENC 008493
Page 43
TABLE 4G
(Review date 1 January 1988)
BURGHAUSEN | W GERMANY |
ST FONS FRANCE
BRIGNOUD FRANCE
1
|
| i
1
|
|
SUNDSVALL SWEDEN
1
| |
NIAGARA USA
1
| |
SPLIT
1
|
YUGOSLAVIA!
1
MARL
|
W GERMANY |
START-UP DATE LATENCY PERIOD OF ASL CASES IN SPECIFIC PLANTS!4-9 CASES)
1933 1939 1950 1945 1947 1950 1948
1 17,21,22,25,24,13,21,32,30
1 1
1 21,28,29,37,38,27,41,34
1 1
1 11,16,18,26,30,25,34
1 1
1 16,19,27,29,31
1 1
1 15,17,21,23
1 1
1 20,20,22,23
1 1
1 15,16,22,21
1
l
1 1
1
I
1 1 1
!
1 1
I
1 1 1 1 1 1 1 1
i
NO OF CASES
AVERAGE PERIOD
1
9 1 22,77 years
1
1
8 1 31.88
1
1
7 1 22.85
1
1
5 1 24.4
1
1
4 1 19
1
1
4 1 21.25
1
1
4 1 18.5
1
NB: Does not include US41 (Niagara): details not known
WPX/ASL2 - LANGIOCASES,18
GENC 008494
!
Page 44
TABLE 4H
(Review date 1 January 1988)
LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPECIFIC PLANT
(4-9 CASES)
' "-----------------
YEAR OF
IburghausenI ST FONS brignoud! SUNDSVALLl Niagara! SPLIT | marl
1
FIRST EXPOSURE 1 W GERMANY 1 FRANCE
FRANCE 1 SWEDEN 1 Usa 1 YUGO-lw GERMANY1
11
1
1 1 slaviai
|
1939
1 1
I
1
1
1 11
|
1
| I|
I
1940
1
1
1
| |I
|
I1
1 37,41
1
| |I
|
21
1
1 I|
31 41
51
1 38
1 1
1
1
1 27*
| | |
11
1) 1|
i | |
6
7
8
9 1950
1
1 1 1 1 1 1
1 29
1
1 28,34
1 1 1
26,30 34
1 31 1 29
1
|
1
| 19
1 15,23 |
1
1
1
| 17
1
I | | 1 23* |
I
1
|
1
| |
|
I | | j
|
21
1
3 125,32 |
4 I 21
|
5 122,24,30 I 27
I
1 11
1
1
1
1 20
| 22
|
1
1
1 22*
|
|
1
1 21
|
|
|
61
1 21
1
I ||
|
7 1 17
|
1
1 11
!
81
1
18 |
1
1 20
|
|
*
91
1
16,25 |
1 ||
|
1960
121
|
1
1 11
|
11
1
1
1
1
115,16
|
21
31
1 1
1 1 1 121 |
1
| |I
1
4I
I
1 16
|
I|
|
51
1
11 1
I ||
|
61
1
|
| I1
1
7
8
9 1970
1 1
113
1
1 1
|
1
1 1 11
1 1 1| 1V | | | 1 | II
I | | I
11
1
||
||
21
1
1
1 I1
1
11
1
1 11
1
* Monomer worker
NB: Does not include US41 (Niagara): details not known
WPX/ASL2 - LANGIOCASES, 19
GENC 008495
GENC 0 0 3 4 9 6
age 4 5
TABLE 5
(Review Date - 1 Jan 1988)
Annual Incidence of ASL Cases (Date of Death) by Geographical Area
r55 7
1961
2
4 7
8
9 1970
1
2
3 4 5
6
7
8
9 1980
1
2
1983 1984 1985 1986 1987 TOTAL
1f | Western Europe | North America
1I
1 11
1 11 1 11 1 11
1 !1
11 1 11 11 11
14
11
13
16 16 16
1
15
12
11
12
|1 14 |2 |4 |1 |3
17 15
16
15
12
I|4 |0
I1 17 15 13 i3
12
|3 |2 [ |
1 11
|
74* **
|
46**
Rest of World | Annual Total
|1 I1 i1 |1
1 12
|1 I5 13
12
13 I5 318 -|5
1 1 11 2 1 11
19 1 1 io -I5 - 1 10 -|5
13
1 10
17 1 I6
t3 |1 9 I 129
* Includes G03 aerosol can filler but omits It 01 bag extruder
| Cumulative 1
| Total
I
Key Events
1
I1
12
13 1 -'4 I6 17 I 12 1 15 1 17 I 20 1 25 ! 33 | 38
I 49 I 60 1 69 1 79 I 84 | 94 I 99 I 102 ! 112 I 119 I 125 I 128 1 129
I
1 1 1 1 1 1 1 1 1
1 Viola
1 1
| Maltoni | Goodrich
1 1 1 1
!
1 1 1 1 1 1 1 1
** Does not Include the following who are still alive, so far as known: Canll, Frl5 and 22, G31 & 32, UK.14, US33, 36 & 41
TABLE 6
(Review date 1 January 1988)
ASL CASE NUMBERS BY YEAR OF DEATH AND GEOGRAPHICAL LOCATIONS (EXCLUDING It.01)
I KEY 1 | EVENTS 1
I WESTERN EUROPE
1
1 NORTH AMERICA
1| 1 REST OF WORLD I
1 1 11
1
1 1955
16
17
18
19 1 1960 I1
12
13 14
1
1 Cl
1
| C2
1
1
1
1 US8 1 C3
1
1 US5
t
1 1 1 1 1 1 1 1 1
1 Cz2
| I I I
1
1
1
1
I I |
D ! 11
|Viola I Maltoni
6
17
18
19 1 1970
11
12
I3
1 FI
1 G1 | Swl | G2 | Nl,Sw2,UKl,It2 | G3** *
1
i | C4,C5,US4,US7,US10 | US12,US1 6 I US11 | C6,US2
1 C7 I C8.US1,US3,US23
1 1 1 1 1 1 1
| Yl,Y2,Czl
1 1 1 1 1 1 1
|
1 Goodrich I I
4 | G4,G5,UK3 5 | F2,F3,G6,G7,G8,It3
I C9.US13 | US6,US9,US18,US26
1
1 Japl
1
|
16
17
18
1
19 1 1980
| Bl,F4,F5,F6,F7,Sw3
| US19.US20.US22,
| Jap2,Y3
I F8,F9,G10,Gll,Gl2,Sw4
| C10.US21,US24*
1
I F10,F11,G9,G13,G15
I US27.US28
1 Y4
| G16.G17
1
1
1 FI 2,FI 3,UK4,UK5,G18
1
1
1 UK6, UK7,G19,Sw5,G20,G21US | US17, US29, US30.US321
|
1
|
1
I |
I 1 1 It4,Fl4,UK8,G22,G23
1
1 2 1 G26
I US31.C12
1 3 1 UK09,It5,F17,B2,G24,G25,G30| US35, US34, US38
I 4 i UK10, F16, F18, G27,G29 1 US37.US39
1 5 1 UKU, UK12,F19,F20,G28 1 6 1 F21,UK13,It6
1V
1
17 1 Total | 74***
| US40 1 46***
1 1 1 1
1 Jap3
1 1
19
I
1 1
1
|
1 1
|
1 1 11
* Cholangiosatcoma ** Aerosol can filler *** Does not include the following who are still alive,
FrL5 & 22, G31 & 32, UK14, US33, 36 & 41
so far as
known:
Canll,
WPX/ASL2 - LANGIOCASES.21
GENC 00849?
Page 47
(Review date 1 January 1988) TABLE 7
ASL CASE NUMBERS BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL LOCATION (EXCLUDING It.01)
KEY | EVENTS |
1
| WESTERN EUROPE
1
| NORTH AMERICA
1 REST OF WORLD!
11
1
11
1
1 1939 1
| US24*
1 40 1
1
1 1 IFrl1,Fr16
| C3.US27
1 21
1 US13, US29,US40
1 3 1 Frl 4
1 C2.US19
4 IUK1
1 Cl ,C5 ,US5 ,US7 ,US28 ,US35
1 5 1 Sw2
| C4,US3,US9
I 6 1Frl,Fr3,Sw4
| C7,C9,US8,US11,US21,US31
1 7 1 Sw3
| C6.US22.US26
1 8 1 Fr9 , Frl 7
| US1
1 9 1Frl2,Fr4
| US12
1 50 1Fr7,N1,UK8,UK9
I US1 6
|Y2, Cz2
1 1 1Swl,UK5,Fr20,G30
I US10, US32
1 2 I G3**
| US4
1 3 |G15,It3,G26,G31*** | CIO, US37
IJapl.Yl
1 4 IG7,G8,UK4,G19
1 US18.US33***
IY3
1 5 1 Gil,G16,G18, Frl5*** I US2,US17,US20,US34
1 1G23,G28,G32***
1
1 6 IFR10.G1
! US36***
1
7 |Fr8,G4,It2,G2,UK12
1
| Cz 1
1 8 !Fr6,B1 ,Fr22***
| US2 3
|Jap2,Y4
1 9 |Fr2,It4,Frl9,Fr21
1
1 60 |G5,G13,G25,G28,It6
I US39
1 1 |G9,G10,G12,G17,G20,G22| C8
|
I |
| |
Viola
1 1 1 1 1 1 1 1
1
2 |G6,UK6,G21,B2,G29 3 |Frl3, UK7,Fr18 4 I Sw5 5 I Fr5,UK11 6 |UK3, UK10.UK14*** 7 1 It5 8 IUK13 9 1G24 70 1
| US6 | US38 I US30
1 1
I
1 1
1
IJap3
I
1
2
Maltoni |
3!
1I
1 Total|79
1
1
1 47****
1!
11
19 |
11
1
11
* Cholangiosarcoma (US24) ** Aerosol can filler (G3)
*** Frl5 & 22, G31 & 32, UK14, US33 & 36 are still alive, so far as known
**** Does not include Canll or 12, or US41: details not known
6ENC 008498
WPX/ASL2 - LANGIOCASES,22
Page 48
- LA.NGIOCASES.23
(Review date 1 January 1988)
TABLE 8 WESTERN EUROPE FVC PRODUCERS - START-UP DATES vs ASL CASES (PUTTING 003 & It.01)
| START-UPI COUNTRY NAME | COMPANY NAME I
LOCATION
I ASL CASE NLMBER |
YEAR OF
YEAR 1
1
1
I | 1st Exposure
1931 |West Germany |BASF 1933 |Wtest Germany |Wacker
ILudwigshafen |Burghausen
11 104.07,11,15,23,24157,54,55,53,55,69,60,531
11
1
125,31,32
155
1938 I Italy 1939 |France
iMontecatini |Acna | Kione-Poulenc/ I St Fans
11 103,09,10,11,14 146,48,56,41,43,
1 |Chloe/Atocher 1
115,16,17
155,41,48
1940 I United Kingdar |ICI/EVC
| Runcorn (Closed 1948)
|
IlMted Kingdar |ICI/EVC
|HiIlhouse
101,04,12
144,54,57
1945 I Sweden
|Kerarcrd/Nobel |Sundsvall(Stockvik' 101,02,03,04,05 151,45,47,46,64
1946 |France
| Rhone-Poulenc |Roussillon
|01
146
1948 lUnited KingdcmlBP Chen/TCI/EVC|Barry
103,05,06,07,08,09166,51,62,63,50,50
11
1
110,11,13,14
166,65,68,66
|West Germany ICWH/Huls
|Marl
109,10,26,29
161,61,53,62
1949 | Belgian
ISolvay
| Janeppe
101,02
|58,62
1950 | Frame
|PCUK/Atochan (Brignoud
102,04,05,06,12,19159,49,65,58,49,59,51
11
1
120
|
|France
|Rhone-Poulenc/ I St Auban
107,22
150,58
1
|Holland |Norway
iChloe/Atochen |Shell |Norsk
1
IPemis, Rotterdan IHeroya, Porsgrunn
1 1 101
1 1 150
1951 I Switzerland 1952 |Italy
I Italy
ILonza/ ICI/EVC ISins
| Montedison
ITtemi
| Montedison/EVC |Porto Marghera
1
1
102,06
1 1 |57,60
1953 |Austria | Frame
lHalvic/Solvay IHalleln
ISolvay
ITavatK
1
108,13,18
1 157,63,63
|Italy
|Solvay
1 Ferrara
103
|53
|Spain
|Rio Rodano
IHemani
lUnited Kingdom|WjBIP/NCKSK lAycllffe
|West Germany IHoechst
IGendorf
1
1
118
1 1 155
1954 |West Germany IDynamit
|Troisdorf
101,02,08,12,16,17156,57,54,61,55,61,
1955 1956
1958 1960
1
|Spain | Spain
1
|West Germany I Italy
1 J\ (Monsanto Iberia |Monzon
ICaiqsa
[Sabinanlgo
| Hispavic/Solvay | Torrelavega
ISolvay
IRheinberg
|S C Ravenna/EVC|Ravenna
119,20,21,22,27,30154,61,62,61,55,51
11 11 11 11 |04 |59
IVfest Germany ILonza/ICI/EVC IWaldshut
106,13,28
162,60,60
1961 1962 1965
1Italy IPortugal I France
| Montedison/EVC I Brindisi
ICires
ICporto
iKhone-Poulenc IMontlucon
1
1
121
1
1 |59
I Italy |Italy
|Pozzi iPensac
IFerrandina IMLra, Venice
1
105
1 |67
I West Germany IVfacker 1966 |West Germany IHoechst
|Cologne
1
1Knapsack/Frankfurt)I05*
1 160
1967
1968 1969
|France
lAtochem
|Spain
|Rlo Rodano
I Greece
|Esso Pappas
| Belgian
IBadlphil
lUnited Kingdom|Vinatex/Norsk
IBalan (Miranda de Ebro IDiavata Salonika |Antwerp I Staveley
1 1 1
1 1 1i
ficur nnAAQC
IItaly
|Runanica/EVC 1 Cagliari Sardina i
i
i
Continued
Page 49
Table 8 - Continued WESTERN EUROPE FVC PRODUCERS - START UP DATES vs ASL CASES (OUTTPC GQ3 & It.01)
| START-UPI COUNTRY NAME | COMPANY NAME |
LOCATION
I TEAR 1 | 1970 I Italy
1
|SIR
1
| Porto Torres Sar
1 United Kingdom| ICI/EVC
| Runcorn
| 1971 |Spain
IHispavic/Solvay|Martorell
|Sweden
IKananord/Norsk |Sterungsund
|United Kingdom|BP Chen
IBaglan Bay
| 1972 I Finland
|Feksna
|Svartback
|Holland
|D9i
|Beek Limburg
1 1976 |France
|Soc Art D'vinyl|Mazingarbe
1
l(CDF)
|
1 1977 |Spain
|Monsanto Iberlal Tarragona
| 1982 IVfest Germany 1ICI/EVC
|Voslapp
1|
IWiLhelmehaven
1 ASL CASE HJMBER |
11 11 11 11 11 11 11 11 11 11 11 11
!1
YEAR OF 1st Exposure
* Laboratory worker in Research Department
WPX/ASL2 - LAN3IOCASES.24
GENC 008500
(Review date 1 January 1985)
TABLE 9
USA PVC PRODUCERS - START-UP DATES vs ASL CASES
1 START-UP 1 COMPANY NAME
LOCATION
1 ASL CASE I YEAR OF
YEAR
1 NUMBER
1 1st EXPOSURE
1939? |*UCC
S Charleston
107,13,19,21,24, 149,42,43,46,39,
| Dow
Midland (made
127,28,29,31.35 141,44,42,46.44 |1
1940? I *BFG
Saran copolymer) 1
1
Louisville
101,02,03,04,05, 148,55,45,52,44,
106,09,16,17,22, 162,45,50,55,47,
1946 1*UCC/Dow 1947 | Goodyear
126,33,34,37,40 147,54,55,53,42
Texas City (Partially closed 1977) 1
Niagara Falls
108,10,11,20,41 146,51,46,55,?
1948 | Firestone/
Pottstown
I 12
149
I Occidental | Uniroyal
Painesville
1
I
1 1
1950 1 Monsanto
(closed 1975) Springfield
1 132
1
151
1952 | Dow | BFG
(Closed 1975
|
Midland (No PVC since c 1975)
Avon Lake
118
1
1
154
1953 | Diamond/BFG 1954 | General Tire/ **
Deer Park Ashtabula
| |36
1
156
| DiversiTech
(Closed 1984. Reopened 1986 by Vygen)
1956
1 Air Products | Atlantic Refining | Borden | Conoco | BFG | Great American
Pensacola (Pace) |
Brooklyn(Closed late 1960s)
Leominster (Closed 1984)
Hebronville (Closed 1975)
Niagara
I
Fitchburg
123
1 1 1 1 1
158
| Plastics | Hooker | Pantasote
(Closed 1983)
|
Hicksville (Closed 1980-81)
Passaic(Closed 1984) 39
1
1
|60
1957 | Atlantic Tubing | Tenneco/
Cranston (Closed 1967)
Flemington NJ
130
1
159
| Occidental
(Closed 1985)
|
1
1958 | Keysor Century | Air Products
Saugus, Cal \ | Calvert City(Paducah)
38
1
163
(Closed March 1982 Re-opened October 1983)
1960
1962 1963
| BFG
| Borden 1 Tenneco/Occidental | Conoco/Vista
Long Beach, Cal (No PVC now.
Formerly shown as Watson)
Illiopolis
I
Burlington NJ
|
Aberdeen, Miss
|
1 1
I
1 1
1 Stauffer 1965 1 Conoco/Olin
Long Beach, Cal (Closed 1982)
1
Assonet, Mass (Closed by Olin 1975)
| Ethyl
Baton Rouge (Closed 1984)
1
1966 1 Diamond/Georgia
Delaware City
|
1
1 Gulf |Gen Tire/Pantasote
1
Mt Pleasant W Va |(Closed 1982)
1 1
| BFG 1 Stauffer/Formosa
Henry, 111
|
1
Delaware City (Sold to Formosa 1981)
1967 | Allied/Robintech/ Painesville, 0. (No PVC made by Robintech.
1968
| Georgia Pacific
GP converted to polystyrene)
| Hooker/Occidental Burlington NJ
|
1 Firestone/Occidental Perryville (Closed 1982)
1 1
1 GENC 008501
WPX/ASL2 - LANGIOCASES,25
CrTtnM nnprl
TABLE 9 (Continued)
USA PVC PRODUCERS - START-UP DATES vs ASL CASES
!START-UP 1 1 YEAR 1 I 1969 1
1
1 1971 1 1 1972 1 1 1973 1 I 1974 I
1
1
1 1975 1
1
1
1
| 1979 1
1
| 1983 1 1 1986 1
COMPANY NAME
I
1
BFG I
Goodyear/BFG
I
Conoco/Vista
|
Nat Starch
|
Borden
I
Atlantic Tubing/ 1
Tallyrand
Shintech
I
Certain-teed
I
Georgia Pacific/ I
Georgia Gulf
1
Tenneco/Occidental I
Firestone/ Occidental Formosa Vygen
I I I ** I
LOCATION
|
Pedricktown NJ
1
|
Plaquemine
|
Oklahoma City
|
Meredosia, 111
|
Springfield
|
Cranston RI (Closed
ASL CASE NUMBER
1982)
Freeport, Tex Lake Charles Plaquemine, La
| | |
Pasadena, Tex
1
|
Addis (formerly shown as
Plaquemine)
|
Point Comfort, Tex|
Ashtabula, Ohio 1
i YEAR OF
|
1 1st EXPOSURE 1
1
1
1
1
1
1
1
1
!
1
1
1
1
1
1
1
* My databank has no information on UCC before 1946 or BFG before 1950 ** Refer to same plant at Ashtabula, bought by Vygen from DiversiTech.
NB Some of the plants in this list were closed down, some have changed ownership over the years, some have changed their product.
WPX/ASL2 - LANGIOCASES,26
GENC 008502
Page 52
(Review date 1 January 1988)
TABLE 10
CANADIAN PVC PRODUCERS - START-UP DATES vs ASL CASES
START-UP| YEAR |
1
1943 1 (1941?) 1
1951 1957
1 1 1 1 1 1
1966 1979
1 1 1 1 1 1
1
COMPANY NAME
Goodrich (Formerly Gulf)
Monsanto
|
1
1 1
|
1 1
|
Goodrich
1
|
Esso (Imperial Oil)
1
I |
1
1
Diamond Shamrock Alb/|
BF Goodrich
|
LOCATION
I ASL CASE I NUMBER
1 YEAR OF 1 1st EXPOSURE
Shawinigan
11
101,02,03,04,05 144,43,41,45,44,
106,07,08,09,10 ,147,46,61,46,53
111,12
1?,?
1
La Salle (Closed 1975)
1 1
11
1
Welland (? Niagara)
1 1
11
Sarnia
1 1
1 1
11
1
Fort Saskatchewan 1
1 1
11
WPX/ASL2 - LANGIOCASES,27
GENC 008503
Page 53
(Review date 1 January 1988)
TABLE 11
EASTERN BLOC PVC FACTORIES - START-UP DATES vs ASL CASES
|START-UP I COUNTRY NAME | COMPANY NAME
| YEAR 1
1
IPre 19391 East Germany |State Company
1 1941 |Russia
|State Comps
I 1950 I Yugoslavia
IJugo Vinil
I 1951 1 Czechoslovakia |State Comps
I 1955 |East Germany |State Comps
1 1956 I Rumania
|State Comps
I 1957 |Poland
|State Comps
I Rumania
|State Comps
11
I 1958 |Rumania
|State Comps
1 1959 1 Hungary
(State Comps
1 1961 I Rumania
|State Comps
1 1963 I Yugoslavia
| Ohis
I 1965 |Bulgaria
|State Comps
1 1967 |Poland
|State Comps
l 1969 |Russia
(State Comps
| 1970 I Rumania
(State Comps
1 Russia
iState Comps
| 1972 |Yugoslavia
|Vinilplastika
| 1975 (Czechoslovakia!State Comps
|Russia
IState Comps
| 1976 |Yugoslavia
1 Hip
1 1977 I Rumania
(State Comps
| LOCATION
I ISchopau |Vladimir et al I Split (Novaky |Bitterfeldt |Icechim lOsweicim (Dwory) |Tirnaveni |Turda |Risnov IBerente Borsod IBorzesti ISkopj e |Varna ITarnow | D.ieriinsk |Rimnicu Vilcea (Volgograd |Zadar |Neratovice IKalush Area |Pancevo |Rimnicu Vilcea
| ASL CASE | NUMBER
1
1
101,02,03,04
101,02
1 1
1 1
1
1 1
I
1
1
i
i i i i i i i i
1 YEAR OF ( 1st Exposur'
1 1
153,50,54,48 157,50
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
i
1 1
WPX/ASL2 - LANGIOCASES.28
eENC 0SS04
Page 54
(Review date 1 January 1988)
TABLE 12
JAPANESE PVC PRODUCERS - START-UP DATES vs ASL CASES
I START-UP 1
COMPANY NAME
YEAR 1950
1951
1
1 Chisso Corp 1 Kanegafuchi Kag 1 Tekkosha 1 Mitsui Toatsu
1952 1951
1955 1956 1957 1960 1964 1966 1967 1968 1970
1971 1973 1974
1 Mitsubishi Mon 1 Sumitomo Kag 1 Denki Kagaku
! Nippon Zeon 1 Toa Gosei 1 Ryo-Nichi 1 Nippon Zeon 1 Nisshin Kagaku 1 Kureha Kasei 1 Shinetsu Kag I Denki Kagaku 1 Kanegafuchi Kag 1 Chisso Corp 1 Tokuyama Seksul i San Arrow Kagak I Sumitomo Kag 1 Ryo-Nichi 1 Shinetsu Kag 1 Chisso Corp 1 Denki Kagaku 1 Kanegafuchi Kag 1 Kawasaki Yuki 1 Mitsui Toatsu 1 Nissan Kagaku 1 Shinetsu Kag 1 Tekkosha
1 Asahi Glass 1 Toyo Soda
1975 1977
1
1 Central Kagaku 1 Toyo Soda 1 Unknown
| LOCATION
I | Minamata | Osaka | Sakata | Nagoya | Yokkaichi | Kikumoto I Shibukawa 1 Kambara | Tckushima | Uozu | Takoaka | Takeo | Nishiki | Naoetsu I Ohmi | Takasago | Chiba I Tokuyama | Tokuyama | Chiba | Mizushima | Tokuyama | Mizushima 1 Goi (Chiba) | Kashima | Kawasaki | Sakai | Chiba I Kashima | Yokkaichi | Hayatsuki | Sakata | Yokkaishi I Kawasaki | Yokkaichi | Kashima
| ASL CASE | NUMBER
1
| 02
1
1 01, 03
1 1
!
1 1 1 1 1 1 1
I
1
!
1 1 1 1 1
i
1 1 1 1
V| vI
1 1 1 1
1 1 1
1 YEAR OF 1 1st EXPOSURE
1
1 58
1
1 53, 65
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
I
1
GENC 008505
Page 55
(Review date 1 January 1988)
TABLE 13
SOUTH AND CENTRAL AMERICAN PVC PRODUCERS
I START-UP 1 I YEAR 1 I 1953 1 I 1954 1 I 1955 1 1 1956 1 I 1960 1
1
I 1961 ! 1 1965 1 I 1966 1 I 1967 1
1
1 1968 1 1 1970 1
1
1 1971 1 I 1975 1 1 1976 1 1 1977 1 1 1978 1
1
1
1 1979 I
COMPANY NAME
Monsanto Mexica Policyd Geon Do Brazil Elchlor/Solvay Electrochlor Viplastic Indupa PET Columbiana Carburo De Col Plasticos Omega SOC Paramonga Primex Policasa Petro Dow Politneros Mex Rico Chemicals Petroplas Indust Resistoc Huls Brasil Polychem Policyd PET Camacari
I LOCATION
1
I1
I Lecheria (Mexico)
1
I Mexico City (Mexico)
1
| Sao Paulo (Brazil)
1
| Sao Caetano (Brazil)
I
ICapitan Bermudez( Argentina) 1
| Mend'oz (Argentina)
1
| Cinco Saltos (Argentina) 1
| Cartagena (Colombia)
1
| Medellin (Colombia)
I
| Mexico
1
I Paramonga (Peru)
1
| Puebla (Mexico)
1
| Managua (Nicaragua)
1
I Conception (Chile)
1
| St Martin Puebla (Mexico) !
| Guyanilla (Puerto Rico) 1
| EL Tablazo (Venezuela)
1
| Tlazcala (Mexico)
1
! Cubato (Brazil)
1
| El Salvador
1
I Coatzacoalcos (Mexico)
1
| Camacari Bahia (Brazil) 1
ASL CASE NUMBER
1 YEAR OF I 1st EXPOSURE I!
i i i i
i i i i i i i i i i i i i i i i
V
WPX/ASL2 - LANGIOCASES, 30
GENC 008506
Page 56
fA.-. (Review date 1 January 1988)
TABLE 14 AUSTRALASIAN PVC PRODUCERS
START-UP DATES
START-UP YEAR
COMPANY NAME
Mid 1950s ICI Australia
1960s B F Goodrich
Late 1970s ICI Australia
| LOCATION |
| Botany, Sydney |
| Melbourne
|
| Laverton | Melbourne
| |
ASL CASE NUMBER
1 YEAR OF 1 1st EXPOSURE
1 1
1 1 1 1 1 1
WPX/ASL2 - LANGIOCASES, 31
GENC 00850?
(Review date 1 January 1988)
TABLE 15 MIDDLE EASTERN PVC PRODUCERS
START-UP DATES
START-UP 1 COUNTRY NAME
DATE
1
1
Sept 1986 1 Saudi Arabia
1
1
!
1
1
1
* COMPANY NAME *
LOCATION
11
11
I National Plastic |Arabian Petrochemical Company
| Company
|Madiant
I (Ibn Hayan)
1Al-Jubail
1 |Al-Sinahyah
1I
11
11
WPX/ASL2 - LANGIOCASES,32
GENC 008508
try:
ICI CHEMICALS 4 POLYMERS LIVER Angiosarcoma Cases - (Review Date: J Jan 19*.)
WPX/ASL - LAMGIOCASES t32
GENC 008
