Document DvV1a6oZv535pzkdVk8w4z5mM

3 h l General Offices 3lLI Center St. Paul, &IN 5 5 1 ~ - 1 0 0 0 612 733 1I10 BACK TO MAIN Document Processing Center (7407) ATTN: Section 8(e) Coordinator Office of Pollution, Prevention and Toxics US Environmental Protection Agency 401 M Street, SW Washington, D.C. 20460 Re: TSCA S(e) Supplemental notice for Sulfonate-based and Carboxylic-basedFluorochemicals-Docket numbers SEHQ-1180-373; 8EHQ-1180-374; 8EHQ-038 1-0394; 8EHQ-0598-373 Dear Docket Coordinator: 3M recently completed analyses of several fluorochemical compounds in individual, stored human sera. We have previously reported results of perfluorooctane sulfonate for human sera from pooled samples.'" In the current analyses, individual samples were measured for sulfonate-basedand carboxylic-based compounds. Table 1 represents samples of 599 individuals from 23 different states in the U.S. in the age span 2-12. These samples were drawn in 1995.Table 2 represents over 600 individuals from six blood banks across the United States, focusing in the age span 20-69. These samples were drawn in 2000. 3M will send a final report on these analyses to the EPA in the near future. Compound Average PFOS C8FI7SO1- 43.5 ppb(aJ I PFHS C6FiJC02- PFOSM C.SFI~SO~N(C~HI)- 15.0 ppb 4.4 PPb CHiCOz' M570 CsFI~SO- ~N. (C-H, ,)CHICOY 3.4 ppb PFOSA <LLOQ CaF17SO?N- MS 56 3.0 ppb CpF17SOzNH- CHzCOz- PFOA C7F15COY 5.6 ppb iMedian 36.7 ppb 3.5 ppb 3.7 ppb 1.8 ppb <LLOQ 2.5 ppb 5.1 ppb 9 S h percentile 90.2 ppb 71.3 ppb 10.4 ppb 12.5 ppb <LLOQ 7.3 ppb 10.2 ppb Range 6.7-5 15 ppb <LLOQ(b)-712 ppb CLLOQ-23.8 ppb <LLOQ-48.0 ppb <LLOQ <LLOQ-19.1 ppb <LLOQ-56.1 ppb Compound [ Average PFOS CsF,7S03- 1 43.7ppb PFHS CbFljC02- 1 29ppb Median 35.8 ppb 1.6 ppb I 9sthpercentile Range 1 90.5 ppb j <LLOQ-I656ppb 1 I 1 9.6 ppb <LLOQ-66.3ppb BACK TO MAIN Section 8(e) Coordinator May 15,2001 Page 2 Please contact me at 651-733-5181 for additional questions relative to the above analyses. gp?g?jg Sincerely, PIcD Larry R. Zobel, MD MPH Staff Vice President & Medical Director 3M Medical Department (1) Letter to TSCA 8(e) Co-ordinator, May 15, 1998 (2) Perfluorooctane Sulfonate: Current Summary of Human Sera and Toxicology, January 2 1, I999