Document Dv4m4g3mzr168zvGEp0JNV2Ya

CONTENTS Bibliographic information............................................... ii Ordering reports.............................................................. Hi Prices of reports............................................................... iii Sample citation.......................................... in About NTIS.....................................................................iv About NTISearches.......................................................... v Citations............................................................................ 1 ucc 042725 aw^j.1-- BIBLIOGRAPHIC INFORMATION ,.f _;NTIsrPS-79/04l9 mt ** PJTt^ J,f, Toxicity of Vinyl Chloride CA Bibliography with Abstracts). May 79 -' Elizabeth A. Harrison. National Technical Information Service U.S. Department of Commerce Springfield, Va. 22161 ? ^C V** ` * ` Report period, covered: "Hept. for 1,969-May 79 .,tSupersefesSHtIS/PS-78/0442, JNTIS/PS-7J/0365, and NTIS/PS-76/0197* '' Research is cited on the health' hazards from exposure to vinyl chloride and vinyl chloride resins. Studies are included on the'epidemiology ot Industrial and public exposures to the compound and its degradation and combustion products. (This updated bibliography contains 82 abstracts, 3 of hlohA.r^w .ntrU5tto the previous edition.). ->v w `t. PRICE CODE: J>C M01/MF M01 ' ,-k -W 4 J^5lrwnlng % *,TIWtaa if Mt pakanlH Mtag * Mpynpi w i mppvm. __________i Copyright *t4ana TochnicolWonwHon Sfrico 17. jjndor tho pwiWw of fee UbIwmI Copyright Convention. United 7m copyright It nM Mood under fee United Statee Copyright Law.. ^ 17. United StMoCodo. SS&Hfcxf&i, '. ..*&- X, = > 7*?^ i>r Vi ' f" T?fc i. ' 0.1 i *1'j fc ' 1 .7 svitfe'.?- * ucc 042726 USER INFORMATION Ordering Reports Most documents cited in this Published Search are available directly from NTIS. When NTIS does not sell a document, the abstract will note the source from which the document may be obtained. An NTIS order form (see last page) is included for your convenience in ordering documents. Prices of Reports Please refer to the price schedule inserted in this Published Search to obtain the correct paper copy and microfiche prices of the reports you order. Printed prices in the abstracts have been susperseded in most cases. Sample Gtatioe from the NTIS Data Base Mitre Corn.. McLean. VA. 'Environmental Protection Agency, of Toxic Substances. (402-364) Final rent. AUTHOR: Roberts, Elizabeth. Spewak, R., Stryker, S,, Tracey, S. CS945F4 FLD: 06T 06F 57Y*. 57H. 68*' USGRDR7606 Sep 75 I65p* - -- REFT NO: MITRE-7S.52-VoU CONTRACT: EPA-6WI 2933 MONITOR: EPA/560/7.73/001-1 Paper copy alio available in ret of 3 reports ai PB-24S 649-SET. PCS36.00 NTIS Subject Categories Pages in Report Report Date ABSTRACT: In June 1974, toxic substances data in the U.S. were collected and analyzed in 10 key sutes This report describes that effort and discusses the amount, type and usefulness of the data and toxic substances monitorial capabilities of the state agencies contracted. 'DESCRIPTORS: 'EnvenomemaJ surveys. States (United States), Monitors, Toxicology, Arsenic. Beryllium. Cadmium. Cyanides, Lead (Metal). Mercury (Metal). Chlorine aromatic compounds. Data acquisuoa. Data processing. Water pollution. Air pollution. Chemical compounds IDENTIFIERS: Toxic agents. Biphenyl/chloro, State agencies. 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Abstract: Contents: Analytical protocols--(scanning electron microscopy and energy dispersive x-ray analysis; total bromine and chlorine by neutron activation analysis: analysis for ethylene in ambient air; sampling and direct analysis for methyl chloride and methyl bromide in ambient air; sampling and analysis for methyl chloride, methyl bromide, vinyl chloride and vinyl bromide in ambient air; sampling and analysis for chlorinated and brominated hydrocarbons and other chemicals in ambient air; chlorine/bromine sampling and analysis in ambient air: determination of inorganic fluoride in ambient air; acid mist sampling in ambient air; sampling and analysis of volatile halogenated hydrocarbons in soil, sediment, water, vegetation and milk; sampling and analysis of semi-volatile halogenated hydrocarbons in air, soil, sediment, water and biota; ozone measurements); Atmospheric dispersion modeling; Meteorological data; Hourly ozone concentrations in El Dorado, Arkansas. Descriptors: *Environmental surveys, Chemical analysis, Bromine organic compounds, Bromine inorganic compounds. Halogen organic compounds, Veutron activation analysis. Concentration(Composition), Monitoring, Atmospheric diffusion. Industrial wastes. Air pollution. Sites, Ozone, Arkansas, Water pollution. Soil analysis. Sediments, Sampling, Laboratory equipment. Food analysis. Fluorides, Vinyl chloride, Chloromethanes, Ethylene, Electron microscopy, X ray analysis. Chlorine, Bromine Identifiers: Methane/bromo, NTISEPAOTS El Dorado (Arkansas), Ethylene/bromo, PB-286 483/3ST NTTS Prices: PC A08/MF A01 k $ ucc 042730 Investigation of Standards, Performance Characteristics and Evaluation Criteria for Thermoplastic Piping in Residential Plumbing Systems National Engineering Lab. (NBS) , Washington, D.C. ^Department of Housing and Urban Development, Washington, D.C. assistant Secretary for Policy Development and Research. Building Science Series (Final) ATT? HOF.! Wyly, P. s.; Parker, w. J.; Pierce, E. T.; Rorrer, D. ; Shaver, J- P-. E2245J3 Fid: 13B, 13K, 89F*, R9G, 94 GSAI7821 Hay 78 153p* Rept No: NBS-B5S-111 Project: NBS-4624190 Monitor: 18 Library of Congress Catalog Card no. 78-600037. Sponsored in part bv Department of Housing and Urban Development, Washington, D.C. Assistant Secretary for Policy Development and Pesearch. Abstract: The application of the performance concept to ,the evaluation of piping systems of innovative materials is explored. user needs are considered and several material-related physical parameters are studied that might be used as measures of satisfaction of the user needs. Information was reviewed on usage, performance characteristics and standards for thermoplastic pipe and fittings, and special laboratory tests were made to study selected characteristics and test methods. A number of performance statements and evaluation methods are recommended or discussed that relate to characteristics associated with polyvinyl chloride (PVC) , acrvlonitrila-butadiene-styrene (ABB) and chlorinated polyvinyl chloride (Cpvc). This approach was taken to illustrate the application of performance evaluation methodology to plumbing materials. Descriptors: *Plastic pipes, Plumbing, Residential buildings. Performance evaluation. Thermoplastic resins. Polyvinyl chloride, ABS resins. Piping systems. Acoustic properties. Fire safety. Toxicity, Shock resistance. Dimensional stability. Utilization, standards Identifiers: NTISCOMNBS PB-282 495/1ST NTIS Prices: FC A08/HF A01 ucc 042731 Hazard Evaluation and Technical Assistance ceport no- TA 77-58, King Soopers, Inc., Colorado Springs, Colorado national Inst, for Occupational Safety and Health, Cincinnati, Hazard Evaluations and Technical Assistance Branch. AOTHO?: Gunter, Bobby J. E135532 Fid: 6J, 6T, 570, 57Y, 94D, 68G 1EAI7814 Aug 77 9p Rept No*. NIOSH/TF/TA-77/58 Monitor: 18 Ohio. Abstract: A Hazard Evaluation and Technical Assistance survey was conducted by NIOSH on June 23, 1977, at the King Soopers Inc., Denver, Colorado. The survey was prompted by a request from the management regarding the concern of 6 'affected' employees about possible overexposure during the burning of polyvinyl chloride wrap. Based on the results of air sampling which failed to reveal the presence of detectable levels of polyvinyl chloride decomposition products in the breathing zone of the 4 workers present during the survey, it appears that a toxic situation did not exist at the time of evaluation. Three of the 6 employees did complain of upper respiratory irritation caused by fumes coming from the hot wire used to cut the polyvinyl chloride film. One worker was on workmen's compensation due to overexposure to fumes from the plastic wrap. Recommendations are made for improving working conditions and preventing potential exposure. Descriptors: ^Hazardous materials, *Industrial medicine, *Eood industry, *Polyvinyl chloride, *vinyl chloride resins. Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene, Concentration(Coisposition), Medical examination. Environmental engineering. Environmental surveys. Food packagirig, Packaging material , Air pollution. Respiratory system, Colorado Identifiers: *Toxic substances, *Dccupational safety and health. Threshold limit values. Maximum permissible exposure level, King Soopers Incorporated, Air sampling, Colorado Springs(Colorado), NTISHEHOSH RB-278 964/2 ST NTTS Prices: PC A02/MF A01 UCC 042732 B VI organic Chemicals in Occupaticnal and Experimental Carcinogenesis (Excluding Best Pclycyclic Hydrocarbons Nitrcso Compounds) National Cancer Inst., Eethesda, Md. International Cancer Research ta-a Eank. special listing. ECUOUA2 Fid: 61, 6J, 510*, 25 Ncv 77 uip* Sept he: HCI/ICECE/SL-T6/57 Boriter: 18 57U G? AI7805 Abstract: The Special Listing of Current Cancer Research Projects is a service of the International cancer Research Data Each (IC3E3) progra cf the Rational cancer Institute, ^ach listing contains description of ongoing projects in ere selected cancer research area. This listing includes research areas in: Cancer risk associated with cccupaticnal exposure to specific organic chemicals; carcinogenic effects and metabolism cf axe dyes, arylamines and other isccyclic aromatic hydrocarbon derivatives in animal mcdels; carcincgenicity and metabolism cf aliphatic hydrocarbon derivatives in animal models; carcinogenicity testing of ethylene halides and other saturated aliphatic halchydiccarbon derivatives: carcinogenicity and metabolism of heterocyclic compounds in animal mcdsls; and broad programs, and other studies cn chemical carcinogenesis in animal models. ^Descriptors; -Malignant neoplasms, -Research projects, -Industrial medicine, -Organic compounds. Carcinogens, Metabolism, vinyl chloride, Chlorchydrocarbcrs, Aromatic hydrocarbons, Azo, dyes, Arylamines, Aliphatic hydrocarbons. Halides, Etbylenes, Halchydrocarbons, Heterocyclic compounds Iden-ifiars: -Listings, -Cancer, -Hedical research, -carcinogenesis. Health risks, Ether/Chlorcmethy1, NtlSHiHICS NTISUB/C/296-0C 4 NTIS Prices: PC A0 3/MP AC 1 4 yee 042733 A Cress-Secticr.al Epidemicloaic Survey cf Vinyl chloride workers National Inst, for Occupational Safety and Health, Cincinnati, chio. Civ. cf Surveillance, Hazard Evaluation and Field Studies.**Bureau of Epidemiclcqy, Atlanta, Ga. Cancer and Birth Defecrs Eiv,*North Carolina Oniv. at chapel Hill, N.c. Occupational Health Studies Group. **cntef icre Hospital# Pittsburgh, Pa. Dept, of Redicir.e. AUTHCF: Watveiler, Richard J Falk, Henry; r.cHichael, Anthony; Mallcv, Joseph s.; Grivas, A. Scctt BC32UK2 Fid: 6j, 57D, S4D, 66G GFAI78C4 Jur. 77 EOp Mor.itcr: DHES/PTJE/NICSH-77/177 Prepared in cooperation with Eureau of Epideaiolcgy, Atlanta, Ga. cancer and Firth Defects Div., North Carolina Oniv. at Chapel Hill, N.C. occupational Health Studies Group, and Montefiore Hospital, Pittsburgh, Pa. Dept, cf Hedicire. Abstract; The extent to which vinyl chloride -monomer induces clinical detectable abnormalities among workers occupationally exposed was investigated during a cross-secticr,a 1 medical survey at a chemical plant which had a polyvinyl chloride polymerization operation, a polyvinyl chloride fabrication operation, and a rubber tire production operation. The survey of 433 predominantly white male employees, divided into four vinyl chloride exposure groups (never, light, heavy, former), determined the prevalence of illnesses and abnormalities based on data gathered by interview, medical examination, blood and pulmonary function tests, liver scans, and hand and chest x-rays. Age-ad-justed analyses indicated that hepatomegaly, central nervous system symptoms, diastclic hypertension and spouses' fetal wastage (the latter two statistically significant) were mere prevalent among past cr present vinyl chloride exposed workers thhn among controls. Ther was r.c excess of respiratory system problems, acroosteolysis, Raynaud's phenomenon, and chromosome aberrations as compared with industrial worker controls. Descriptors: ^occupational diseases, ^Industrial medicine, *vinyl chloride, ^Chemical industry, *Rubber industry, Pclyvinvl chloride. Epidemiology, Liver diseases. Nervous system disorders, fcy perter.sior, Pregnancy complications, Aborticr, Toxicity, Chlorchydrocarbons Identifiers: Health surveys, Cccupaticnal safety and health. Environmental health, NTISHEWCSB PE-274 193/2ST NTTS Frices: PC A0 3/KF AC 1 5 ucc 042734 Heal*h Hazard Evaluat ic r./Tcxicity De terminate on Feport 76-65-348, Sheller-Globe Corporation, Union City, Indiana. Hardy Division National Ins'*-, for Occupational Safety (390 766) AUTHCF; Salisbury, Stanley A, EC252EU Fid: 6J, 6T, 570, 577, 9UD, Doc 76 9p Eept No: NIOSH-TF-HHE-76-65-348 Monitor: 18 and Health, Cincinnati, 68G, 68A GBAI7833 Ohio. Abstract: A health hazard evaluation determination performed by nicsh on July 12 and 13, 1976, at the Hardy Division of the Sheller Globe Corporation in Union City, Indiana revealed that employees working with or near the polyvinyl chloride injection molding process are not exposed to detectable levels of vinyl chloride vapors. The determination was based cn direct measurements and collected air samples taken during both normal and purging operations of an injecting mcldir.a machine. Hydrogen chloride, a thermal decomposition product of polyvinyl chlorida, was also not detected during the injection melding operation. Descriptors: Thermoplastic resins, *Hazardcus materials, industrial medicine, Environmental surveys, *Vir.yl chloride, Hydrogen chloride, Polyvinyl chloride, Plastics industry. Toxicity, industrial hygiene. Toxicology, Evaluation, Inspection, Air pollution, Heccmmendations, criteria, Tapers, Holding techniques, Interviews, Chlcrchydrocarbons, rinyl resins Identifiers: *Er.vironmental health. Air sampling. Toxic substances, occupational safety and health, *Air pollution ef fects (Humans) , Sheller-Globe Corporation, Union city(Indiana) , NTISHEHOSH PF-273 S25/8ST 'TIS Prices: PC AC2/MF AC 1 6 ucc Thermal Stability and Tcxicity cf Fclymers: Polyphosphazenes Pittsburgh nniv Fa Eept of Metallurgical and Materials Engineering 402241) ( Master's thesis AOTHCF: Sebata, K.; Maaill, J. E.; EC22 - E4 Fid: 111, 6T, 710, 57Y U Kcv 77 46p Rept No: SETFC-MKE-77-109 , TP-1 Contract: N00C1U-77-C-C31C Mcnitcr: 18 Alarie, Y. GBAI78C3 Abstract: The tcxicity of thermal decomposition products (in air) of polyaryloxyphcsphazece and pclyflucrcalkcxyphosphazene was evaluated in terms cf their sensory irritation stress index (S,I.S.I.) using nice to ascertain certain adverse physiological effects. The results are compared with some other polymeric materials (cf commercial interest) that have already been investigated elsewhere. A comparison of all these data shows that the hazard rating for the thermal decomposition products of PTFE, PVC-A (PVC resin; 45.5%, ph+halate plasticiser; 32%, filler (CA.CC3); 41 V 5% , FVC-C (PVC resin: 92%, fill-r: 2%), polyflucrcalkcxyphcsphazene, pclaryloxyphospfeazene based on the S.3.S. I. was found to be PTFE greater than PVC(A), pvc-c, greater than polyfluoralkcxyphcsphazene greater than pciyaryloxyphosp- hazene. Thermogravimetric and differential thermogravimetric analysis were made cn these two polyphcsphazene resins in a nitrogen atmosphere at different heating rates. The polyflucrcalkoxyphosphazene decomposed with a single activation energy of 39.8 kcal/mole leaving no residue whereas the polyalkoxypfcosphazene exhibited twc processes wit activation energies of 37.7 kcal/mole and 23.7 kcal/mcle respectively. The latter alsc left a substantial residue which can be associated with its improved behavior over the flucrc-material. (Author) Descriptors: P hcsrbazer.e, Decomposition, pht h.alatas, Nitrogen Plastics, Thermal degradation, *Toxic hazards. Senses (Fhysiology), Irritation, Mice, Polymers, Thermal stability. Flammability, Polyvinyl chloride. Plasticizers, Fillers, Thermogravimetric analysis, identifiers: vpoly (aryloxyphosphazene) , Fcly (flucroalko xyphosphazene) , NTISCCDXA AC-AC46 776/7ST NTTS Prices: FC A03/MF AC 1 St 11fir 042736 J Health Hazard I valuation/Toxicity Determination Report 76-28-332, welch Plastics ar.d Manufacturing Company, Columbus, Ohio Naticral Inst, for Occupational Safety (390 766) ADTHOP: Geissert, J. 0.; Herbert, J. D3161A4 Fid: 6J, 6T, 570, 57y, 9D, Sen 76 25p Kept Ko: 3ICEH-TF-75-28-332 Monitor: 18 and Health, Cincinnati, 68G GRAI7720 Ohio. Abstract: Exposures cf employees tc chemical agents at a molding operation cf the Welch plastics and Manufacturing Company in Columbus, Ohio, were net feund tc be toxic under the conditions observed by the national Institute for Occupational Safety and Health (NXOSH) hazard evaluation personnel. Worker exposures to benzene, bis-chlorcmethyl ether, 2,6-ditert-butyl-p-cresol, carton monoxide, formaldehyde, hydrogen chloride, hydrogen cyanide, particulates, phthalates, styrene and vinyl chloride were determined ty personal and area air sampling, "he workers experienced upper respiratory and eye irritation associated with the use of a regreund polyvinyl chloride and acrvlcnitrile-butadiene-pclys+yrane material. The use of this material has been discontinued. descriptors: ^Hazardous xaterials, industrial medicine. Particles, Hydrcgar cyanide. Toxicity, Criteria, inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres. Exposure, Respiratory system. Eye (Anatomy), Fsspiratcry in fee*ions, Personnel, Benzene, Cresols, carbcn monoxide. Formaldehyde, Hydrogen chloride, Phthalates, Styrene, vinyl chloride Identifiers: Plastics industry, ^occupational safety and Health Act of 1970, *?oxic substances, Columbus (Ohio), Air sampling. Threshold limit values. Maximum permissible exposure leval, Ether/chloromethyl, TTIS EIWOSE PR-265 11 1/1 ST FTIS Prices: PC A02/MF AC 1 8 ucc 042737 Toxicity of Plastic Combustion Products. Toxicological Hethodologies to Assess the Relative Hazards of Thermal Decomposition Products from Polymeric Materials Pittsburgh Dniv. , Pe. Graduate School of Public Health.*Hational Bureau of Standards, Hasbing+on, D.C. (284 15C) Special rapt. AUTHOR: Alarie, Y.; Barrow, S, D2790I4 Fid: 61, 577, 68G Feb 77 313p Grant: HBS-5-90 05 Bonitcr: NES-GCB-77-85 C. GEAI7716 Abstract: Sensory and pulmonary irritation effects of thermal degradation products from natural and synthetic materials were studied using mice. Bice were used to develop a sensory irritation stress index based cr. changes in respiratory rat=.- in addition, acute lethality was obtained, Dcse-respcnse curves were generated for decomposition products from Douglas Fir, pvc, flexible polyurethane, teflon, and fiberglas reinforced polyester. Similar data ' were obtained for cc, CC2, low C2, acrolein, FC1 and C12. Preliminary studies on *he pulmonary effects of combustion products using rabbits are also reported. Descriptors: ^Plastics, *Toxicity, ^Hazardous materials, Combustion products. Inhalation, Chlorine, Hydrogen chloride. Toxicology, Hethcdclcgy, Bice, Laboratory animals. Experimental data, Eyrolysis, Exposure, Tables (Cata) , Polymers, lethal dosage. Bioassay, Rabbits, Polyvinyl chloride. Polyurethane resins, Tetrafluorcethylene resins. Fiberglass reinforced plastics, Folyester resins, Carton monoxide, Carbcn dioxide, Cxygen, Acroleins, Douglas fir wood Identifiers: Toxic substances. Animal models, NTISCCHKES PS-267 233/5ST NTIS Frices: PC A14/KF A01 9 ucc 042738 Registry of Toxic Effects of Chemical Substances. 1976 Edition Tracer Jitcc, Inc., Rockville, Md.* National Inst. for Occupational Safety and Health, Rockville, Hd. (u-C8 825) Annual rapt. AUTHCf: Christensen, Herbert I.; Eenior.a S.; Lewis, Richard J, Sr E2659A3 Eld: 6T, 6J, 57Y*, 579, Gun 76 1358p* Contract: EF.EB-21C-75-CC3`i teniter: NICSH-76/191 Snpersedas PE-296 57. Fairchild, Edward J.; Carroll, 68G*, UUG, 9D* GEA177 15 Abstract: The 1976 edition of the Fegistry of Toxic Effects of Chemical Substances, fcrxerlv referred to as the Toxic Substances List, is prepared annually by the National Institute for Occupational Safety and Health (NIOSH) in compliance with the occupa tior.al Safety and Health Act cf 1970. The 1976 FEGISTRY contains some 82,908 listings cf chemical substances; 5,228 acre than the 1975 edition. Its purpose is tc previae basic informatict on the known toxic and biological effects of chemical substances for us cf employers, eployees, physicians, industrial hygienists, toxicologists, researchers, and in general, all concerned with safe handling of chemicals. The absence of a substance frem the REGISTRY does not indicate that it is not toxic. Drugs cr therapeutic chemicals in the REGISTRY have been included if they have been reported tc produce a noxicus affect. Descriptors: *Toxicologv, *Chemical compounds, ^Hazardous materials, indexes(Documentaticn) , Public health. Desags, Toxicity, Industrial hygiene. Standards, Chemical properties. Exposure, Asbestos, Pesticides, carcinogens, vinyl chloride. Aquatic biology. Regulations Identifiers: *Tcxic substances, ^occupational safety and health. Maximum permissible exposure level. Occupational Safety and Health Act Cf 1979, NTI5HEWCSH PE-266 295/5ST NTTS Prices: PC A99/HF AC 1 10 ucc 042739 Health Hazard Evaluation/Toxicity Determination Report Hum fcer 75-16G-3C9, Water Well Drillira Companies, western Tennessee National Inst, for Occupational Safety (390 766) AUTHCF: Gilles, D.; Hatch, L. D2C82K2 Fid: 6J, 6T, 570, 57Y, 94D, J 01 76 10p Pept No: NIOSE- TR-75- 1 6- 30 9 tcnircr: 18 and Health, Cincinnati, 68G, "4G GRAI7711 Chio. Abstract: On the tasis cf medical and environmental data collected at the Bater Well Drillers in Western Tennessee, the use cf polyvinyl chloride (PVC) cement is not found to constitute a health hazard under existing conditions of use. Environmental samples show only low levels of tetrahydrofuran and no detectable levels cf cyclohexanone. Responses tc medical questionnaires indicate no symptoms associated with exposure tc the chemicals. Descriptors: *Pclyvinyl chloride, medicine. Wells, Drilling, cements. hygiene. Environmental surveys, Cyclohexanones, Toxicology *Razardcus materials, Industrial Industrial atmospheres. Industrial samplinq, Chlorohydrocartons. Identifiers: *Toxic substances, occupational Safety and Health Act of 1970, N115HERCSH PE-263 e59/1ST HTIS Prices: PC A 02/MP A01 11 ucc 042740 Research Ercaram cn Hazard Priority Banking of Manufactured Chemicals (Chemicals 21-4C) Stanford Research Inst., Menlo Park, calif.^National Science Foundation, Washington, D.c. Research Applied to National Needs. ( 332 5C0) Final rept. on Phase 2 AUTHOR: Brcwn, S. L.; Chan, F. Y.; Jones, J. L.: Liu, D. K D1655I2 Fid: 7A, 6T, 6EH*, 66, 99B*, S7Y* GRAT77C8 Apr 75 195p* Project: SRI-F.CO-3386 Monitor: ^SF/PA/F-190B See also EE-263 161 and PE-263 163. E. ; McCaleb, Ahstrac*: In Phase II of this two-phase effort, 8C chemicals having * he oreatest potential for environmental ef*ects were studied. Information was collected on the extent of the axposure of the environment te these chemicals (during manufacture and use) and on the possible environmental effects cf this exposure (chemical, physical, and biological properties, persistence, and toxicity). The chemicals studied in this vcluae are as follows: Benzene (chemical uses). Silicone fluids, Nitrobetzere, Tcluenadiisocyanate (TDI), xylenes - mixad tctal, Aniline, Dimethyl terephthalate, Trichlcroflucrcmethane, p-Dichlorcbenzene, ritfcicbis (benzctbiazcle), c-Cichlorobenzer.e, fcetrabrcaoethane, Methylene (bis)-2-chloroanilir.s, polyhalogenated piphenyls (Aroclor 1254), Tricresyl phosphate. Fluorescent brightening agents (no. 28), Folyviryl chlcride. Methylene chloride, Diehlcropropena, Dichlcropropane mixture, and , Ethyl chloride. (Portions of this document are net fully legible.)'" Descriptors: *Hazardous materials, ^Chemical industry, *Environmental impacts, *Organic compounds. Manufacturing, Utilization, Chemical properties. Physical properties. Toxicology, 3ioassay, Public health. Tables (Data), Releasing, Air pollution, water pollution, Chemical analysis. Soil analysis, Benzene, Silicones, Mitrobenzenes, Xylenes, Aniline, Eiphen.yl, Polyvinyl chloride, Chloroetfcan.es, Fluorescence, Optical brighteners. Industrial wastes, Ealoqsr. organic compounds Identifiers: Met hana/tricfcloro-fluoro, BsnzeDe/dichlcrc, Hthane/tet.ra- breme, Arcclcr 1254 , Prcpane/dichloro, Methylan.e/chlorc, Isccyanic acid/(Methylphenylene-ester) , Terephtbalic acid/ (Dimethyl-ester), Eenzcthiazole tfcicls, Aniline/N-N-bis (Chlcromethyl), Phosphate/tricre- syl, FT IS NSFFA, NTISSRI PE-263 162/CST NTIS Prices: PC AC9/MF AC 1 '1 2 ucc 042741 Research Program cn Hazard Priority Ranking of Manufactured Chemicals (Chemicals 1-20) Stanford Research Inst., Menlo Park, Calif.^Rational Science Foundation, Washington, D.C, Eesearch Applied to national Seeds. ( 332 SCO) Final rept. cn Phase 2 AUTHCF: Brown, S. I.; Chan, F. Y.; Jones, J. L. ; liu, D. K. I. 1165511 Fid: 71, 6T, 68H*, 66, 99B*, 57Y* GRAI77C8 Apr 75 196p* Project: SSI-ECU-3386 Monitor: NSF/RA/E-75/19CA See also EB-263 162. E. ; McCalefc, Abstract: in Fhase II of this twc-phass effort, 8C chemicals having the areatest potential for environmental effects were studied. Information was collected on the extent of the exposure of the environment to these chemicals (during manufacture and use) and on the possible environmental effects of this exposure (chemical, physical, ar.d biological properties, persistence, and toxicity). A questionnaire survey of industry was conducted to determine the amount and types of losses in the manufacturing plaits. Information from this survey is tabulated. Ihe following summary reports are submitted for each of the 8C chemicals: (11 A flow diagram shewing industrial data on the amounts used for various applications; (2) A one-page assessment cf the data gathered cn toxicology and environmental persistence; (3) A computer printout of a tubular summary cf the important data gathered; and (4) Copies cf the 25 most pertinent abstracts found in the area cf tcxicclcgy. The report is divided into five volumes; included in this volume are chemicals 1-20. (Portions cf this document are not fully leqible.) Descriptors: *Hazardous materials, *chemical industry, ^Environmental impacts, *crganic compounds. Manufacturing, Utilization, Chemical properties, physical properties. Toxicology, Bioassay, Public health. Air pcllutior. Tables (Data), Releasing, Finyl chlcride, crescls. Ethyl benzene, Vinylidene chloride. Toluene, Carbon tetrachloride. Water pollution. Soil analysis. Chemical analysis, Dichlorcdiflucrcmethane, Tetraethyl lead. Chlorine aliphatic compounds, industrial wastes. Phenols, Halogen compounds Identifiers: Nonanals, Benzopyrenes, Benzene/hexachloro, Ethylene/trichlorc, Ethane/trichlcro, Ethylsne/chloro, Phosphor.ium c hloride/tetzakis(Hydroxymethyl), But adiene/hexachloro, Ethylene/dibr- omo, Ethylene/diefclorc, Phcsphate/tris (Dibromoprcpyl) , NTISNSFFA, NTISSF.I FB-263 161/2ST NTIS Prices: PC A09/ME A01 13 ucc 042742 r search Program on Hazard Priority Ranking of Manufactured Chemicals (Chemicals 21-40) Stanford Research Inst., Menlo Park, Calif.*National Science Foundation, Washington, D.C. Research Acplied to National Needs. ( 332 50C) Final rept. on Phasa 2 3rown, S. X*., Chan, F Y., Cones, J. I, i.iu, D. H., McCalso, K. i. D1655I2 Fid: 7A, 6T, 68H*, 68, 99B*, 57Y* GSAI77C8 Apr 75 195p* Project: SRI-ECU-3386 Monitor: NSF/3A/E-190B See also PB-263 161 and PB-263 163. Abstract: In Phase II of this two-phase effort, 80 chemicals having the greatest potential for environmental effects were studied. Information was collected on the extent of the exposure of the environment to these chemicals (during manufacture and use) and on the possible environmental effects of this exposure (chemical, physical, and biological properties, persistence, and toxicity). Che chemicals studied in this volume are as follows: 3enzene (chemical uses), silicone fluids. Nitrobenzene, Toluenediisocyanate (TDI), Xylenes - mixed total. Aniline, Dimethyl terephthalate, Trichlorofiuoromethane, p-Dichlorobenzene, Dithiobis (benzothiazola) , o-Dichlorobenzer. s, Tetrabromoethane, Methylene (bis)-2-chloroaniline, Polyhalogeaated' biphenyls (Aroclor 1254), Tricresyl phosphate. Fluorescent bngntsning agents (no. 28), Polyvinyl chloride. Methylene chloride, Dichloropropene, Dichloropropane mixture, and Ethyl chloride. (Portions of this document are not fully legible.) Descriptors: *Hazardous materials, *Chemical industry, Environmental impacts, ^organic compounds. Manufacturing, Utilization, Chemical properties. Physical properties. Toxicology, Bioassay, Public health. Tables (Data) , Releasing, Air pollution, water pollution. Chemical analysis. Soil analysis. Benzene, Silicones, Nitrofcenzenas, Xylenes, Aniline, Biphenyl, Polyvinyl chloride, Chloroethanes, Fluorescence, Optical brighteners. Industrial wastes. Halogen organic compounds Identifiers: Methane/t.richloro-fluoro, Benzene/dichloro, Zthane/tetra- bromo, Aroclor 1254, Propane/dichloro, Methylene/chloro, Isocyanic acid/(Methylphenylene-ester), Terephthalic acid/(Dimethyl-ester), Benzothiazole thiols, Aniline/N-N-bis (Chloromethyl) , Phosphate/tncr e- syl, NTISNSFHA, NTISSRI PB-263 162/OST NTIS Prices: PC AQ9/MF A01 14 UCC <*2743 Research Program on Hazard Priority Ranking of Manufactured Chemicals (Chemicals 1-20) Stanford Research Inst*, Menlo Park, Calif.*National science Foundation, Washington, D.C. Research Applied to National Needs. ( 332 5C0) Final rept. on Phase 2 Brown, S. 1*, Chan, F. Y. , Jones, 0. X.., liu, D. H., McCaleb, K. E D165511 Fid: 7A, 6T, 68H*, 68, 99B*, 57Y* GRAI7708 Apr 75 196p* Project: SRI-ECU-3386 Monitor: NSF/RA/E-75/190a See also PB-263 162. Abstract: In Phase II of this two-phase effort, 80 chemicals having the greatest potential for environmental effects were studied. Information was collected on the extent of the exposure of the environment to these chemicals (during manufacture and use) and on the possible environmental effects of this exposure (chemical, physical, and biological properties, persistence, and toxicity). A questionnaire survey of industry was conducted to determine the amount and types of losses in the manufacturing plants* Information from this survey is tabulated. The following summary reports are submitted for each of tne 30 chemicals: (1) A flow diagram showing industrial data on the amounts used for various applications; (2) A one-page assessment of the data gathered on toxicology and environmental persistence; (3) A computer printout of a tubular summary of the important data gathered; and (4) Copies of the 25 most pertinent abstracts found m the area of toxicology. The report is divided into five volumes; included in this volume are chemicals 1-20. (Portions of this document are not fully legible.) Descriptors: *Hazardous materials, 'Chemical industry, Environmental impacts, *Organic compounds. Manufacturing, utilization. Chemical properties, physical properties. Toxicology, Bioassay, Public haaltn. Air pollution. Tables(Data) , Releasing, vinyl chloride, cresols, Ethyl benzene, vinylidene chloride. Toluene, carbon tetrachloride, water pollution. Soil analysis. Chemical analysis, Dichlorodifluoromethane. Tetraethyl lead. Chlorine aliphatic compounds, industrial wastes. Phenols, Halogen compounds Identifiers: Nonanals, Benzopyrenes, Benzene/hexachloro, Ethylene/trichloro, Ethane/trichloro, Ethylene/chloro, Phosphonium chloride/tetrakis(Hydroxymethyl), Butadiene/hexachloro, Ethylene/dibr- omo, Ethylene/dichloro, Phosphate/tris (Dibromopropyl) , NT IS NS FR A, NTISSRI PB-263 161/2ST NTIS Prices: PC A09/MF A01 35 * Toxicology of Plastics Having Contact with Blood. Report of Program prograss Travenol tabs., Inc., Morton Grove, 111.*National Heart,, Lung, ana Blood Inst., Bethesda, Md. Annual rept. Josephson, A. M. D1503C4 Fid: 6T, 6L, 57Y, 95C GRAI7707 May 75 22p Contract: MO1-HB-2-2990, PHS-72-2990 Monitor: NIH-NO1-HB-2-2990 Abstract: Di-2-ethylhexyl phthalate (DEHP) was extracted from polyvinyl chloride (PVC). This material was diluted in sterile rat plasma and used to inject, IV, groups or rats with a 3.7 mg/kg/injection, which is equivalent to the DEHP dose that a patient would receive from a total exchange transfusion of blood. Growth rates, gross reactions following injections, hematology and serum chemistry parameters, gross organ pathology, absolute and relative organ weights, histopathology# and residual DEHP levels m plasma and tissues were similar for all groups, including plasma control groups. No toxicology significant changes were observed. rt i+ Descriptors: ^Toxicology, *piasticizers, Polyvinyl chloride, Toxici , Plastics, Medical supplies. Medical equipment. Blood, 3ioassay, Ea , Laboratory animals Identifiers: *Phthalic acid/bis(Ethylhexyl-ester) , *3lood compatible materials. Biomaterials, NTISNIHHLI PB-262 260/3ST NTIS Prices: PC A02/MF A01 I6 UCC 042745 Special Listing of Current Cancer Research on Carcinogenic Substances in Food and Drugs (Along with Related Epidemiology) Smithsonian Science Information Exchange, Inc., Washington, D.C. Current Cancer Research Project Analysis Center.^National Cancer Inst., Bethesda, Md. International Cancer Research Data Bank. D1492F3 Fid: 6H, 60, 6E, 98H*, 57Q*, 57E, 68G* GRAI7707 24 Nov 76 28p* Monitor: NCI/ICHDB/SL-76/25 See also PB-261 670. Abstract: ;Contents: Aflatoxins and other organic naturally occurring carcinogens; Oncogenic food additives, residues, and environmental contaminants; Epidemiology cf cancer in relation to diet; Influence of dietary factors on susceptibility to chemical carcinogens in experimental animals; Oncogenic side-effects of drugs. Descriptors: ^Malignant neoplasms, ^Carcinogens, *Foods, *Drugs, Etiology, Diet, Food additives. Pollution, Environments, Nitroso compounds. Amines, Vinyl chloride. Esophageal carcinomas. Breast neoplasms. Chemical compounds. Tolerances (Physiology), Epidemiology, Antineoplastic agents, Reserpine Identifiers: Aflatoxins, Mycotoxins, Biotoxins, Nitrosoamines, *Cancer , Environmental health, NTISNIHNCI PB-261 671/2ST NTI5 Prices: PC A03/HF A01 V7. ucc 0*42746 Problems of occupational Hygiene and the state of Health of Workers Employed in Manufacturing Latex Polyvinyl Chloride (Voprosy Gigieny Truda i Sostoyanie Zdorovya Rabochikh, Zanyatykh na Proizvedstve Lateksnoyo Noliviailkhlorida) Environmental Protection Agency, Research Triangle Park, N.c. Translation Services Section. Filatova, 7. S., Gronsberg, E. Sh., Smirnova, N. A., Stulova, E. A., Oreshkevich, I. V. D1345G3 Fid: 6J, 6T d7706 1965 10p Rept No: EPA-TR-76-366 Monitor: 18 Trans, of Gigiena Truda i professionalnye Zabolevamya (USSR) v9 r.8 p9-14 1965. Abstract: Pollution of the air with vinyl chloride and resin dust is possible during the manufacture of latex polyvinyl chloride. Such pollution is caused by disruption of the seal of equipment and by carrying out certain operations manually. During the study of the state of health of the workers, some of them were found to have changes characteristic for the initial forms of chronic vinyl chloride intoxication: slightly pronounced disorders of the vegetative-vascular regulation, symptoms of vegetative polyneuritis and thermoregulatory disorders. An improvement in the conditions of labor of workers employed in manufacturing latex polyvinyl chloride can be attained by m ans of sealing the equipment, improving technological operations and improving the function of ventilation. Descriptors: ^Polyvinyl chloride, industrial hygiene, ^Toxicity, ^Hazardous materials. Health status. Toxic diseases. Manufacturing, Industrial medicine. Translations, USS3, 'Toxicology, Industrial atmospheres. Recommendations, Pathology Identifiers: Occupational safety and health. Toxic substances, *Air pollution effects (Humans), NTISEPAISD PB-261 764-T/ST NTIS Prices: PC A02/MF A01 18- UCC 042747 Occupational Vinyl Chloride Intoksixatsii Vinilkhloridom) Intoxication (0 Profes ionalnoi environmental Protaction Agency, Research Triangle Park, :i.C. Translation Services Section. Antonyuzhenko, V. A. D1345G2 Fid: 6J, 6T d7706 1968 6 p Rept No: EPA-TR-76-365 Monitor: 18 Trans, of Gigiena Truda i Professionalnye Zabolevamya (USSR) v12 n3 p50-52 1968. Abstract: Cases of acute vinyl, chloride intoxication in workers are extremely rare and are usually due to massive exposure to the substance during work in closed areas and during accidents. Under the indicated conditions even short-term breathing of vinyl chloride car. cause sudden loss of consciousness and a state of narcosis. In those cases when the patient is not immediately removed from the gas-filled room, a coma may develop that is lethal as the result of respiratory arrest. Hith timely rendering of first aid, patients soon emerge from the comatose condition, but consciousness may remain clouded for a short time. Over the next few days, headache, dizziness, general weakness and an inclination to bradycardia and arterial hypotony are observed. The patient practically recovers in 5-7 days. Descriptors: *vinyl chloride, *lndustrial hygiene, *Toxicity, Hazardous materials, *Toxic diseases. Chemical compounds. Translations, Chlorine organic compounds. Industrial medicine. Industrial atmospheres, USSR, Respiration, Gases, Toxicology Identifiers: occupational safety and health, effects(Humans), Toxic substances, NTISEPAISD *Air pollution PB-261 763-T/ST NTIS Prices: PC A02/SF A01 39 UCC 042748 Currant Awareness Service for Toxic Substances (CATS). Cumulative Report Number 2. Part II Little (Arthur D.), Inc., Cambridge, Mass.^Environmental Protection Agancy, Washington, D.C. Office of Toxic Substances. (208 850) Annual rept. D1241B2 Fid: 13B, 6?, 68*, 57Y* GRAI7705 Nov 76 364p* Rapt No: ADL-C-77355-Pt-2 Contract: EPA-68-01-2694 Monitor: EPA/560/7-76/002a Sea also report dated Dec 75, PS-250 075 and Part 1, P3-26G 360. Abstract; The scanning topics included in this two part series are the chemicals and subject areas as follows: Acetonitrile, acrylonitrile, arsenic, aryl phosphates (phenyl, cresyl, mixed phenyl-cresyl), asbestos, benzidine, and salts (hydrochloride, sulfate), boron, brominated biphenyls, dichicrobenzidine, dioxane, ethylsneimine, flame retardants, fluorocarbons, haloethers, hexachlorobenzene, hexachlorobutadiene, hydrazine, derivatives, and salts (sym and unsym - dimethyl, monomethyl), isocyanates (organic), liquefaction and gasification of coal, methylsnebis (chloroaniline), model ecosystems (environmental fate testing, microecosystems), aaphthylaminss (alpna, beta, N-phenyl derivatives) , nitrilotriacetic acid, optical brighteners (fluorescent whitening agents, fluorescent dyes), perchloroethylane, phthalates (dioctyl, di-2-ethylhexyi), polyurethanes, propiolactone, trichloroethylene, shale oil extraction and refining, vinyl chloride, vinylidene chloride, ethylene dibromide, and nitrosamines. Descriptors: *Toxicity, *Chemical elements,' *Pollution, Vinylidene chloride resins. Acetonitrile, Acrylonitriles, Arsenic, Phosphates, Cresols, Phenols, Asbestos, Nitrosamines, Lactones, Benzidine, Boron, Biphenyl, Dioxanes, Aziridines, 'Fire resistant materials, Fluorohydrocarbons, Ethers, Halogenorganie compounds. Coal gasification. Hydrazines, Isocyanates, Ecosystems, Amines, Optical brighteners, Phthalates, Polyurethane resins, Naphthalenes, Shale oil. Extraction, 3efining, Vinyl chloride Identifiers: Biphanyl/broao, Benzidine/dichloro, Coal liquefaction, Benzene/hexachloro, Buta diene/hexachloro, Anilins/N-N-bis(Chlorometh y1), Naphthylaminas, Acatric acid/nitrilo-tri, Ethylene/chloro, Ethylene/trichloro, Ethylene/dibromo, NTISEPAOTS PB-26D 361/1 ST NTIS Prices: PC A16/MF A01 20 ucc 042749 Current Awareness Service for Toxic Substances (CATS). Cumulative Report Number 2. Part I Little (Arthur D.), Inc., Cambridge, Hass.*Environmental Protection Agency, Washington, D.C. Office of Toxic Substances. (208 850) Annual rept. D1241B1 Fid: 133, 6T, 68*, Nov 76 4Q7p* Rept No: ADL-C-77355-Pt-1 Contract: 3PA-68-01-2694 Monitor: EPA/560/7-76/002 See also Part 2, PB-260 361 . 57Y* GRAI7705 Abstract: This cumulative report contains 26 current awareness documents prepared biweekly from 25 August 1975 through 9 August 1976 during the second year of a two year project. The purpose of this project was to provide the Office of Toxic Substances (OTS), U.S. Environmental Protection Agency with information on new uses of existing chemical products and with information of obvious potential environmental concern for both new and existing chemical products. For each biweekly document a core list of approximately 8C journals was scanned for information of interest to OTS on more than 30 topics (compounds, classes of compounds, and subject areas, e.g., model ecosystems) . Abstracts were prepared for all items selected and these abstracts ware presented biweekly under the assigned topics, in addition, a 'General Information' section was added to accommodate abstracts for topics not included in the original list of scanning topics. Biweekly subject indexes were cumulated for this annual compilation, and an author index was added. Descriptors: *Toxicity, *Pollution, Vinylidene chloride resins. Acetonitrile, Acrylonitriles, Arsenic, Phosphates, Cresols, Phenols, Asbestos, Nitrosamines, Lactones, Benzidine, Boron, Biphenyl, Dioxanes , Aziridines, Fire resistant materials, Fluorohydrocaroons, Ethers, Halogenorganic compounds. Coal gasification. Hydrazines, Isocyanates, Ecosystems, Amines, Optical brighteners, Phthalates, Polyurethane resins. Naphthalenes, Shale oil. Extraction, Refining, vinyl chloride Identifiers: Biphenyl/bromo, Benzidine/dichloro, Ccal liquefaction, Benzsne/hexachloro, Butadiene/hexachloro, Aniline/N-N-bis (Chloromethy1), Naphthylaminas, Acetric acid/nitrilo-tri, Ethylene/chloro, Ethylene/trichloro, Ethylene/dibromo, NTISEPAOTS PB-260 360/3ST NTIS Prices: PC A18/HF A01 Tag So-Called vinyl vinylchlorid-Krankheit) Chloride Disease (Ueber die Sogenannte 3 tm nvironmental Protection Agency, Research Triangle ranslation Services Section. Juehe, S., Lange, C. -E., Stein, G., Veltman, G. D0345B1 Fid: 6J, 6T, 570, 57Y, 68g GSAI7702 1975 15p Kept No: EPA-TR-75-6 Monitor: 18 Trans, of Deutsche Medizinische wochenschrift (West p2334-2037 n.d. Parle, N.c, Germany) v98 Abstract: Since the first reports on impairments of health of workers in the vinyl chloride (VC) industry appeared in 1958, and of workers in the polyvinyl chloride (PVC) industry in 1963, attention has been repeatedly directed at this branch of the chemical industry by further reports. A syndrome was observed which was similar in its skin and bone changes to scleroderma, while its etiology and pathogenesis remained unresolved. Its principal symptom was the Raynaud syndrome -- nodose or surface hard skin changes and band-shaped osteolyses of the finger end-phalanges. The first observations of this disease pattern was reported in Germany in 1972. The authors have recently made an exhaustive report on the results obtained through the end of 1972, which reveal new aspects in the assessment of the disease. The most important features are summarized. Descriptors: 'occupational diseases, 'Vinyl chloride, industrial medicine, Integumentary diseases, Toxicology, Dermatology, Chemical industry. Skin diseases. Signs and symptoms. Gases, Pathology, pathophysiology. Histology, Best Germany, Translations Identifiers: Air pollution effects (Humans), Environmental health. Occupational safety and health, NTISEPAISD PB-258 838-T/ST NTIS Prices: PC A02/HF A01 Standard Support and Environmental Impact Statement, Volume 2. Promulgated Emission Standard for Vinyl Chloride Environmental Protection Agency, Research Triangle Park, N.C. Office of Air Quality Planning and Standards, D0344L3 Fid: 13B, 6J, 6F, 7A, 68H, 68, 68A, 57U, 57H GEAI77G2 Sap 76 135p Hept No: EPA/450/2-75/009b Monitor: 18 See also PB-249 703. Abstract: A national emission standard for vinyl chloride emitted from ethylene dichloride-vinyl chloride and polyvinyl chloride plants is being promulgated under the authority of section 112 of the Clean Air Act. vinyl chloride has been implicated as the causal agent of angiosarcoma and other serious disorders, both carcinogenic and noncarcinogenic, in people with occupational exposure and in animals with experimental exposure to vinyl chloride. Reasonable extrapolations from these findings cause'concern that vinyl chloride may causa or contribute to the same or similar disorders at present ambient air levels. The purpose of the standard is to minimize vinyl chloride emissions from all known process and fugitive emission sources in ethylene dichloride-vinyl chloride and polyvinyl chloride plants to the level attainable with best available control technology. This would have the effect of furthering the protection of public health by minimizing the health risks to the people living in the vicinity of these plants and to any additional people who are exposed as a result of new construction. This is estimated to have the effect of reducing emissions from a typical ethylene dichloride-vir. yi chloride plant by approximately 94 percent and from a typical polyvinyl chloride plant by approximately 95. percent. This document contains a summary of the public comments on the proposed standard and EPA's responses to the comments. It also contains updated information concerning the environmental and inflationary impacts of the standard. Descriptors: *Air pollution control, ^Environmental impact statements, vinyl chloride, ^Hazardous materials, chemical plants. Cost analysis. Economics, Public health. Industrial wastes. Combustion products. Law enforcement. Standards, Industrial hygiene. Particles, waste water, Water pollution. Pesticides, Aerosols, Testing, Toxicity Identifiers: Fugitive emissions. Air quality, NTISEPAAWK P3-258 827/5ST NTIS Prices: PC A07/MF A01 23 ucc 042752 Evaluation of Vinyl Chloride Emissions in the Long 3each Area, California National C7694A3 May 74 Bept No: Monitor: Field Investigations Fid: 138, 68A, 68D 47p EPA/330/2-74/002 18 center, Denver, GBAI7625 Colo. Abstract: A survey of vinyl chloride emissions from the American Chemical Corporation and B.F. Goodrich Chemical Company showed that vinyl chloride monomer was leaving the plants via water, sludge, and air as well as in the final product, polyvinyl chloride, it is estimated that about 2.3 icg (5 lb)/day of PVC leave the 3.F. Goodrich plant, and 10 kg (22 lb)/day lBave the American Chemical plant in tne wastewater effluents. Smaller quantities were found in the sludge. The raport presents a plant evaluation and a sampling program. Descriptors: ^Pollution, 'Vinyl chloride, vpolyvinyl chloride. Surveys , Water pollution. Sludge, Air pollution. Infrared spectrometers, Evaluation, Industrial plants. Toxicity, Environmental impacts. Safety , Public health. Assessments, Sampling, California Idsntifiars: Long 3each(California), NTISEPAO P3-257 642/9ST NTIS Prices: PCS4.00/MF$3.00 -24 in :r 042753 Toxicity of the Pyrolysis Products of Spacecraft Materials Tennessee Univ., Senphis. Annual Report, 1 Aug. 1974 - 31 Jan. Lawrence, w. H. C6915C3 Fid: 06T, 22B, 57Y, 84A 29 Mar 76 79 Rept Ho: NASA-CE-147563, A8-2 Contract: NAS9-13617 Monitor: 18 1976. STAH1413 Abstract: Data is presented which provides guides to (1) approximate temperature necessary to initiate thermodegradation of the polymeric materials tested, (2) the relative toxicity of thermodegradatior products from the various materials, (3) the relative importance of carbon monoxide as the primary cause of death (as contrasted to cyanide or other toxic gases), and (4) whether or not the hazards of the fumes are confined to the time of exposure, or whether post-exposure death is likely. Two different experimental methods were employed. (Author) Descriptors: ^Combustion products, `"Pyrolysis, Spacecraft construction materials, ^Toxicology, Carbon monoxide, Carboxyhemoglobin, Nylon (Trademark), Polyimides, Polyvinyl chloride. Eats, Thermogravimetry, Urethanes Identifiers: NTISNASA N76-22887/3ST NTIS Prices; PCS5.00/MFS2.25 25 ucc 042754 mo ampling and Analysis of Selected Toxic Substances. Task III. Vinyl hloride, Secondary Sources Midwest Research Inst., Kansas City, Mo.*Ervironmental Projection Ag ncy, Washington, D.C. Office of Toxic Substances. (230 350) Final rept. 1 hot-31 Dec 75 Going, John E. C6824L2 Fid: 06T, 06?, 13B, 57Y, 573, 68A, Apr 76 30p Contract: EPA-68-01-2646 Monitor: EPA/560/6-76/002 See also report dated Sep 75, PB-246 213. 68G, 99A GRAI7616 Abstract: A sampling and analysis program was conducted to determine whether and to what extent vinyl chloride was present in ambient air due to the presence of polyvinyl chloride products. Sampling environments were chosen to represent real life, but nonwork situations where a significant exposure to'polyvinyl chloride products might occur. A sampling and analysis protocol was developed with a recovery efficiency of greater than 90* and a detection limit of 1L ppb (v/v). The two general categories of environments sampled were vehicles and commercial products. The interior ambient air was sampled from new and used domestic automobiles, foreign automobiles and domestic mobile homes. Mo evidence of vinyl chloride was found. The following commercial vinyl products, when sampled in their normal environment, did not produce a measurable quantity of vinyl chloride in the ambient air: vinyl wall covering; vinyl swimming pool liners; and vinyl nursery products. A room being painted with a heavily pigmented red paint was found to contain a very low level of vinyl chloride. Descriptors: *Toxicology, *Carcinogens, *Vinyl chloride. Air pollution , Automotive industry. Sampling, Exhaust emissions. Combustion products. Public health. Vehicles, Paints, Fabrics, Gas chromatography , Gas analysis, charcoal. Adsorbents, Sites, Sources Identifiers: *Air pollution sampling. Cancer, Environmental health. Secondary sources, NTISEPAOTS PB-252 966/7ST NTIS Prices: PC$4.00/MFS2.25 26 uccry a A*irr Toxicity of components of Plastic Having Contact with Blood Travenol Labs., Inc., Horton Grove, 111.National Heart and Lung Inst., Bethesda, Hd. Div. of Blood Diseases and Resources. Final technical progress rept. Jun 72-Har 75 Hiripol, J. E., Garvin, P. J., Stern, I. J., Wallin, R. F. C6573C3 Fid: 061, 06L, 571, 95C, 95A GHAI7613 Sep 75 340p Contract: N01-HB-22990 Monitor: NIH-NO1-HB-22990 Abstract: Method of solubilization, dosage form and route cf administration are factors which are critical in the distribution and excretion of di-(2-ethylhexyl) phthalate (DEHP), one of the most widely used components employed in the formulation of flexible polyvinyl chloride (PVC). Changes in the apparent volume of distribution of DEHP observed when aqueous suspensions were used for injection of the plasticizer indicated' that differences in the systemic disposition and distribution of DEHP were dependant on the physical state of the dosage form. Valid studies of the biological effects of parenterally administered DEHP must be performed with a dosage form of the plasticizer which is like that encountered in clinical situations. Whole body autoradiographic studies performed on mice infused with serum containing 14C-DEHP showed rapid accumulation of labeled carbon in the kidney and liver with rapid excretion into urine, bile and intestine. Essentially all the labeled compound was excreted within 24 hours. Rats infused twice weekly for b0 days with rat plasma containing DEHP extracted from PVC exhibited no toxicologically significant changes when compared to controls. Tissue residue studies in man revealed no relationship between transfusion history and tissue content of DEHP. Copyright National Technical i Information Service 1976. Descriptors: Plastics, ^Toxicology, polyvinyl chloride. Blood, Phthalates, Medical supplies. Plasticizers, Toxicity, Toxic tolerances , Dosage, Bioassay, Rats, Mice, Laboratory animals. Absorption(Biology), Excretion Identifiers: *Blood compatible materials, Biomatarials, *Phtha`lic acid/bis(ethylhexyl-ester), NTISNIHHLI PB-251 742/3ST NTIS Prices: PC$10.00/MFS2.25 I 2*7 ucc 042756 Toxicology of Plastic Devices Having Contact with Blood Utah Univ., Salt Lake City. Dept, of applied Pharmaceutical Sciences.*National Heart and Lung Inst., Bethesda, Md. Final rept. 24 Aug 72-23 Aug 75 Petersen, Robert V., Lyman, Donald J., Roll, David 3., A. C6282K3 Fid: 06T, 06L, 571, 95A, 95C GHAI7610 23 Aug 75 248p Contract: PHS-73-2908 Honitor: JJIH/NHLI-72-6-F See also report dated 1 May 75, PB-244 753. Swinyard, Ewart Abstract: The project was primarily concerned with toxicological evaluation of polyvinyl chloride and, more specifically, the commonly used plasticizer, di(2-ethylhexyl) phthalate (DEHP) . Evaluations are primarily concerned with long range, subtle toxicity potential, although many basic acute and subacute studies were also conducted. The project is divided into twelve tasks including an organizational phase, plastic composition studies, acute toxicity studies, tissue culture studies, subacute toxicity studies, metabolite identification, teratogenic studies, neurologic studies, larger animal studies, analyses of human blood exposed to plastics during hospital procedures, and possible statistical analysis of human patients following extensive exposure of blood to plastics. Descriptors: *Polyvinyl chloride, ^Plastics, ^Plasticizers, ^Toxicology, Patients, Tissue culture. Bioassay, Laboratory animals. Pathology, Rats, Heart, Phtbalates, Body fluids. Neurology, Mice, Reproduction(Biology), Medical supplies. Mechanical organs. Humans, Blood Identifiers: *Blood compatible materials, Bioma tenals, Phthalic acid/bis(ethylhexyl-ester), Metabolites, NTISNIHHLI PB-250 102/1 ST NTIS Prices: PCS8.00/MFS2.25 23 ucc 042757 standard Support and Environmental Impact Statement: Emission Standard for Vinyl Chloride Environmental Protection Agency, Research Triangle Parte, K.C. of Air Quality Planning and Standards. C6195K4 Fid: 13B, 06J, 06F, 68A*, 68, 57U, 57H GKAI7609 Oct 75 536p* Sept No: EPA/45C/2-75/009 Monitor: 18 Office Abstract: A national emission standard for vinyl chloride emitted from ethylene dichloride-vinyl chloride and polyvinyl chloride plants is being proposed under the authority of section 112 of the Clean Air Act. Vinyl chloride has been implicated as the causal agent of angiosarcoma and other serious disorders, both carcinogenic and noncarcinoganic, in people with occupational exposure and in animals with experimental exposure to vinyl chloride. Reasonable extrapolations from these findings cause concern that vinyl chloride may cause or contribute to the same or similar disorders at present ambient air levels. The purpose of the proposed standard is to minimize vinyl chloride emissions from all known process and fugitive emission sources in ethylene dichloride-vinyl chloride and polyvinyl chloride plants to the level attainable with best available control technology. This would have the effect of furthering the protection of public health by minimizing the health risks to the people living m the vicinity of these plants and to any additional people who are exposed as a result of new construction. This is estimated to hava the effect of reducing emissions from a typical ethylene dichloride-vinyl chloride plant by approximately 94 percent and from a typical polyvinyl chloride plant by approximately 95 percent. Environmental Impact and Inflation Impact Statements quantifying the impacts of the proposed standard and alternative control levels are included in the document. Descriptors: *Air pollution control, ^Hazardous materials, *Vinyl chloride, *Environmental impact statements. Cost analysis. Public health. Combustion products. Law enforcement. Standards, Polymerization, Industrial hygiene. Particles, Filters, Incinerators, Absorbers(Materials), waste water. Water pollution. Solid waste treatment. Noise reduction. Thermal pollution. Pesticides, Aerosols, Chemical industry. Combustion products. Emission Identifiers: Air NTISEPAORD quality. Fabric filters. Fugitive emissions, PB-249 703/OST NTIS Prices: PC$13.00/HFS2.25 23 i 'CC 042758 Scientific and Technical Assessment Report on Vinyl Chloride and Polyvinyl Chloride Environmental Protection Agency, Research Triangle Parle, N.c. Final rept, C6105G3 Fid: 06T, 06J, Dec 75 125p* Rapt No: ZPA/600/6-75/00h Monitor: 18 Sea also PB-246 820. 13B, 57Y*, 57U, 68G*, 68A, 68D GRAI7608 Abstract: Vinyl chloride (VC) is a chemical of widespread industrial and commercial use. Occupational experience and experimental evidence strongly indicate that it is a carcinogen. Additionally, there is experimental evidence that indicates that it may be a teratogen and mutagen. An increased incidence of liver angiosarcoma, excessive liver damage, and acroosteolysis has been reported among VC workers, and the frequency and severity of the liver pathology is related to the length of exposure. The principal route of exposure is thought to be air inhalation. Sources of increased importance for the general population include food and water. Tumors at multiple and diverse sites have been observed in all species of experimental animals tested for carcinogenicity by inhalation and ingestion of VC. In addition to the health effects of VC, this document also considers the sources, distribution, and control technology. Descriptors: Polyvinyl chloride, Vinyl chloride, *Toxicology, Industrial medicine. Air pollution. Public health, liver. Malignant neoplasms. Carcinogens, Mutagens, Slater pollution. Food chains, Humar.s , Laboratory animals, Experimental data, Chemipai compounds. Chemical industry Identifiers: *Air pollution effects(Humacs), *Environmentai health. Teratogens, Air pollution control. Slater pollution effects (Humans) , NTISEPAORD PB-2U9 U61/55T NTIS Prices: PC$5.50/MFS2.25 3-0 Ucr 042759 Health Hazard Evaluation/Toxicity Determination Report h.h.e. 74-94-253, Armstrong Cork Company, Jackson, Mississippi National Inst, for Occupational Safety and Health, Cincinnati, Ohio. (390 766) Final rept. Dec 74-Jul 75 Flesch, Jerome P., Rostand, Robert A. C6104L3 Fid: 06J, 06T, 57U, 94D, 68G Dec 75 16p Rept No: NIQSH-T3-HHE-74-94-253 Monitor: 18 See also PB-249 432. GSAI7608 Abstract: An environmental-medical evaluation was conducted by niosh at a plant manufacturing vinyl asbestos floor tiles. Environmental air samples were obtained, medical records were reviewed, and noa-directed madical interviews were administered. It was determined that exposure to airborne chrysotile asbestos was in'excass of the proposed 05HA standard and that there was a potential for exposure to trace concentrations of airborne vinyl chloride monomer. Worker exposures to other toxic materials were below levels believed to be potentially toxic. Reviaw of medical records revealed no findings suggestive of lung cancer (noting that malignant manifestations of asbestos exposure may take 10-40 years to develop after the exposure has ceased. Descriptors: *Hazardous materials, industrial medicine, ^ Vinyl chloride, *Asbestos, *Silicon dioxide, ^Limestone, Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres. Exposure, Barium, Lead (Metal), Chromium, Zinc, Titanium, Carcinogens, Interviews Identifiers: ^Occupational Safety and Health Act of 1970, *Toxic hazards. Air sampling, Ethane/trichloro, NTISHEWOSH PS-249 433/4ST NTIS Prices: PC$3.50/MFS2.25 Health Hazard Evaluation/Toxicity Determination Report H.H.2. 75-81-252, Artex Manufacturing Company, Inc,, Overland Parle, Kansas National Inst, for Occupational Safety and Health, Cincinnati, Ohio. (390 766) Pinal rept. Nay-Jun 75 Hervin, Raymond L. C6104L2 Fid: 06J, 06T, 57U, 94D, Dec 75 11 p Sept No: NI0S3--TR-HHE-75--81-252 Monitor: 18 See also PB-249 431. 68G GRAI7608 Abstract: A health hazard evaluation was conducted by NIOSH at a plant involved in the silk screen dyeing of decals onto various textile garments. It mas determined that employees in the two main production areas were not exposed to toxic concentrations of vinyl chloride and organic solvents, including 1,1,1-trichioroethane, toluene, xylene, and petroleum naphtha. It was further determined that the clean room operator was exposed to potentially toxic concentrations of organic solvents from cleaning silk screens with an organic solvent containing primarily naphtha. Descriptors: Hazardous materials, Industrial medicine, Vinyl chloride, *Toluene, Iylenes, Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres , Fumes, Organic solvents. Exposure, Chloroform, Naphthas, Textile industry Identifiers: *Occupational Safety and Health' Act of 1970, ^Toxic hazards, NTISH2WOSH PB-249 432/6ST NTIS Prices: PC$3.50/MFS2.25 32 ucc 042761 Health Hazard Evaluation/Toxicity Determination Report H.H.s. 74-24,92,95-246, Uncle Bill's Pick-N-Pay Market, No. 1C, Middlsburg Heights, Ohio, Madsen's Valu Center, Mankato, Minnesota, and Kroger Company, Logan, West Virginia National Inst, for Occupational Safety and Health, Cincinnati, Ohio. (390 766) Final rept. Vandervort, Robert, Brooks, Stuart M. C6104J4 Fid: 06J, 06T, 57U, 94D, 68G GRAI7608 Dec 75 31p Rapt No: NIOSH-TR-HHE-74--24-246, NIOSH-TR-HHE-74-92-246 Monitor: 18 Also available as report no. NIOSH-TB-HHE-74-95-246. See 925. also PB-249 Abstract: At the request of employees from several supermarkets, NIOSH conducted health hazard surveys to evaluate exposures to substances emitted by hot-wire cutting of polyvinyl chloride meat-wrapping films and thermal activation of meat package price labels. Meat department employees ware interviewed and given physical examinations and pulmonary function tests. Blood samples were also obtained. Environmental air sampling was also conducted. Based upon these madical and environmental data and upon other information regarding meat wrapping and labeling operations, it was determined that hot wire cutting of PVC meat wrapping films and thermal activation of price labels can release irritant substances into the work environment. No health hazard exists from vinyl chloride monomer however. Descriptors: *Hazardous materials, ^Industrial medicine, *vinyl chloride, *Hydrogea chloride, "Polyvinyl chloride. Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres. Exposure, Composite wrapping. Identifiers: "Occupational Safety and Health Act of 1970, "Toxic hazards. Air sampling, Phthalic anhydrides, NTISHEWOSH PB-249 426/8ST NTIS Prices: PC$4.00/MFS2.25 f* 33 uoo 042762 Health Hazard Evaluation/Toxicity Determination Report H.H.E. 73-173-244, Borden Chemical company, Leominister, Massachusetts National Inst. for occupational Safety and Health, Cincinnati, Ohio. (390 766) Final rept. Polakoff, Phillip Lee C6104J2 Fid: 06J, 06T, 57U, 94D, Dec 75 14p Sept No: NIOSH-TR-HHE-73-173-244 Monitor: 18 68G GRAI7608 Abstract: NIQSH investigated an alleged health hazard from trypsin, a proteolytic enzyme, and NeJcal B-78, a surfactant, in a plant manufacturing polyvinyl chloride resins. Employees were administered non-directed medical questionnaires, shin tests and pulmonary function tests. It was determined that a number of employees had developed allergic sensitization to trypsin, resulting in respiratory impairment. Some employees who have not been sensitized have still developed mild upper respiratory tract irritation. It was also determined that several employees who handled the surfactant Ns*al 3-78 had periodically experienced upper airway irritation, gagging, and shortness of breath. This problem was judged to be the result of poor work practices and no serious health consequences from this exposure were observed or anticipated. Descriptors: Hazardous materials, *lndustrial medicine, Polyvinyl chloride, Trypsin, *surfactants. Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres , Exposure, Respiratory system, Chemical industry, Allergic diseases Identifiers: Occupational Safety and Health Act of 1970, *Toxic hazards, NTISHEHOSH PB-249 424/35T NTIS Prices: PC$3.50/MFS2,25 34 Health Hazard Evaluation/Toxicity Determination Report H.H.E. 75-90-236, Russell Corporation Alexander City, Alabama National Inst, for Occupational Safety and Health, Cincinnati, Ohio. (390 766) Final rept. Seissert, Jack o. C6104H2 Fid: 06J, 06T, 57U, 94D, Nov 75 12p Rapt No: HIOSH--TR-HHE-75-90-236 Monitor: 18 See also PB-249 415. 68G GRAI7608 vn Abstract: Air sampling for vinyl chloride and medical interviews we conducted by NIOSH to determine if a health hazard existed from t use of polyvinyl chloride-based inks in the screen-printing of garments. Tha potential health hazard of mineral spirits used in cleaning the screens was also evaluated based upon environmental data and information collected during confidential employee interviews. No health hazard was found to exist from vinyl chloride,,however, mineral spirits was found to cause skin problems following worker contact. Descriptors: *Hazardous materials, ^Industrial medicine, *Vinyl chloride, ^Polyvinyl chloride, *lnks, ^Printing inks. Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres. Textile industry. Interviews, Solvents, Skin diseases Identifiers: *occupational Safety and Health Act of 1970, *Toxic hazards. Air sampling, *Hineral spirits, NTISHENOSH PB-249 416/9ST NTIS Prices: PC$3.50/HFS2.25 35 ucc 042764 Tiaalth Hazard Svaluation/Toxicity Determination 74-61-232, Gates Rubber company, Denver, Colorado Report H.H National Inst, for Occupational Safety and Health, Cincinnati, Ohio. (390 766) Final rept. Jun 74-Bay 75 Gunter, Bobby J., Lucas, James B. C6104G2 Fid: 06J, 06T, 570, 94D, Sot 75 16d Rept No: NIOSH-TR-HH2-74-61-232 Monitor: 18 See also PB-249 413. 68G GRAI76C8 Abstract: A plant manufacturing extruded hose, principally from the extrusion of polyvinyl chloride, was investigated by NIOSH to evaluate employee exposures to cyclohexanone, TDI, trichloroethylene, Estane thermoplastic polyurethane, methylene chlpride, Nigrosine, Di-2-ethyl hexyl phthalate (DOP oil), dust, and vinyl chloride. It was determined that a potential health hazard may exist from exposure to cyclohexanone, and that several cases of primary irritant dermatitis had occurred following repeated exposure to solvents. Although only one of 38 vinyl chloride samples was found to exceed the Federal Standard action level, it was recommended that airborne concentrations be reduced to levels not detected by the recommended analytical technigues. Descriptors: *Hazardous materials, Industrial medicine, Vinyl chloride resins, Cyclohexanones, ^Solvents, Organic solvents. Polyvinyl chloride. Isocyanates, Polyurethane resins, Plastics, Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres, Chloromethanes, Hoses, Manufacturing, Dermatitis, Carcinogens Identifiers: *0ccupational Safety and Health Act of 197C, Toxic hazards. Air sampling, NTISHEWOSH PB-249 4 12/8ST NTIS Prices: PCS3.5Q/MFS2.2 5 36 uec Health Hazard Evaluation/Toxicity Determination Report H.H.E. 75-120-22C, storm Products Company, palo Alto, California National Inst. for Occupational Safety and Health, Cincinnati, Ohio. (390 766) Final rept. Okawa, dalvin T. C6104D2 Fid: 06J, 06T, 570, 94D, Sep 75 5p Rept No: NIOSH-TR-HHE-75-120-220 Monitor: 18 See also PB-249 401. 68G GHAI7608 Abstract: NIOSH conducted a health hazard survey at a plant producing finished cables. A small extruder is used to coat wire with PVC plastic or other coating materials. Environmental air samples were collected for vinyl chloride analysis and no detectable amounts ware found on any of the samples. It was concluded that a potential health hazard from vinyl chloride gas does not exist under conditions found during this evaluation. Descriptors: ^Hazardous materials, ^Industrial medicine, ^Polyvinyl chloride, *vinyl chloride resins. Plastic coatings. Gases, carcinogens , Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene, industrial atmospheres Identifiers: ^Occupational Safety and Health Act of 1970, *Toxic hazards, Air sampling, NTISHEWOSH PB-249 4C0/3ST NTIS Prices: PC$3.50/MF$2.25 37 UCC 042766 Health Hazard Evaluation/Toxicity Determination Report H.H.E. 75-94-219, proto Production Plastics, Inc., Boulder, Colorado National Inst, for Occupational Safety and Health, Cincinnati, Ohio. (390 766) Final rept. Ruhe, Raymond L. C6104D1 Fid: 06J, 06T, 570, 94D, Sep 75 6p Rept No: NIOSH-TR-HHE-75-94-219 Monitor: 18 See also PB-249 400. 68G GRAI7608 Abstract: A plant manufacturing polyvinyl chloride telephone switchbox covers by means of an injection molding process was investigated by NI05H to evaluate exposure of employees to vinyl chloride. Air samples were obtained for vinyl chloride analysis and there were no detectable amounts of vinyl chloride found. Non-diracted medical questionnaires were also administered and on the basis of medical and environmental data, it was determined that a health hazard did not exist at the time of this evaluation. Descriptors: ^Hazardous materials, ^Industrial medicins, *Polyvmyl chloride. Vinyl chloride resins. Plastics industry. Carcinogens, Gases , Exposure, Toxicity, Criteria, Inspection, Standards, Recommendations , industrial hygiene, industrial atmospheres Identifiers: *Occupational Safety and Health Act of 1970, *Toxic hazards. Air sampling, NTISHEWOSH P3-249 399/7ST NTIS Prices: PC$3.50/MFS2.25 '* 33 ucc 04276? Health Hazard Svaluation/Toxicity Determination 3-sport H.H.E. 74-118-218, General Tire and Rubber company, Marion, Indiana National Inst. for Occupational Safety and Health, Cincinnati, Ohio. (390 766) Final rept. Dec 74-jan 75 Soper, C. Paul, Cormer, John . Jr C6104C4 Fid: 06J, 06T, 570, 94D, Aug 75 20p Rept No: NIOSH-TE-HHE-74-118-218 Monitor: 18 See also PB-249 399. 68G GRAI7608 Abstract: A plant which manufactured molded urethane cushions for automobile seats and bulk urethane foam for a variety of commercial purposes was investigated by NXOSH to evaluate employee exposure to toluene 2,4-diisocyanate, polyvinly chloride resins, and mold release wax. Environmental measurements were performed, medical interviews and pulmonary function tests were administered, and work practices were observed. It was determined that airborne concentrations of toluene 2,4-diisocyanate are potentially toxic to employees at the foam line in the Slab Department but not in the Molded Foam Department. Particles of mold release wax were found to cause temporary irritant symptoms in some workers. Exposure to polyvinyl chloride resins was not believed to pose any health hazard under conditions observed during this evaluation. Descriptors: Hazardous materials, *lndustrial medicine, Polyvinyl chloride, *Mold release agents. Plastics industry. Isocyanates, Urethanes, waxes. Exposure, Molding materials. Gases, Toxicity, criteria. Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres. Carcinogens, Vinyl chloride resins Identifiers: occupational Safety and Health Act of 1970, Toxic hazards, Isocyanic acid/(methylphenylene-ester)di. Air sampling, HTISHSBOSH PB-249 398/9ST NTIS Prices: PC$3.50/MFS2.25 UCC 042763 wm Health Hazard Evaluation/Toxicity Determination Report H.H.E. 74-59-217, Goodyear Tire and Rubber Company, St. aarys, Ohio National Inst, for Occupational Safety and Health, Cincinnati, Ohio. 1390 766) Final rept. Jul 74-Mar 75 Vandervort, Robert C6104C3 Fid: 06J, 06T, 570, 94D, Aug 75 6p Rept No: NIOSH-TR-HHE--74-59-217 Monitor: 18 See also P3-249 398. 68G GRAI76C8 Abstract: NIOSH evaluated employee exposures to vinyl chloride monomer in the mixing and film casting processes during the manufacture of clear plastic films by the solvent casting method. Air samples were obtained and no detectable levels of vinyl chloride were found. It was determined that a health hazard did not exist at the time of this evaluation. Descriptors: ""Hazardous materials, ""Industrial medicine, "Vinyl chloride, "Polyvinyl chloride, plastics industry. Carcinogens, Toxicity, Criteria, Inspection, Standards, Recommendations, industrial hygiene. Industrial atmospheres Identifiers: "Occupational Safety and Health Act of 1970, "Toxic hazards. Air sampling, N'TISHEWOSH PB-249 397/1 ST NTIS Prices: PC$3.50/MFS2.25 40, ucc 042769 Health Hazard Evaluation/Toxicity Determination 74-125-215, Monaghan company, Denver, Colorado Report H. H. S. national Inst, for occupational Safety and Health, Cincinnati, Ohio. (390 766) Final rept. Dec 74-May 75 Gunter, Bobby J., Butler, George, Lucas, C6104C1 Fid: G6J, 06T, 57U, 94D, 68G Jul 75 8p aept No: NIOSH--TR-HHE--74--12 5-215 Monitor: 18 See also PB-249 396. James B. GRAI76C8 Abstract: A health hazard survey was conducted by NIOSH to evaluate worker exposure to vinyl chloride in a plant utilizing powdered, pelletized, and film, PVC. Based on the results of environmental measurements, employee interviews, limited physical examinations, observation of work practices, and a review of literature pertaining to the toxicity of vinyl chloride, it was determined that a health hazard did not exist at the time of this investigation. Descriptors: ^Hazardous materials, Industrial medicine, vinyl chloride resins, Polyvinyl chloride. Plastics industry. Carcinogens, Gases, Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres Identifiers: Occupational safety and Health Act of 1970, Toxic hazards. Air sampling, NTISHEWOSH PB-249 3 95/5ST NTIS Prices: PC$3.50/MFS2.25 . 4 I. uco 042770 Health Hazard Evaluation/Toxicity Determination Report, H.H.E. 75-20-209, Bichdel Corporation, Carson City, Nevada National Inst, for Occupational Safety and Health, Cincinnati, Ohio. (390 766) Final rept, Mar-Apr 75 Okava, Melvin T. C6104A3 Fid: 06J, 06T, 570, 94D, Jul 75 8p Sept No: NIOSH-TH-HHE-75-20-209 Monitor: 18 Sea also PB-249 390. 68G GBAI7608 Abstract: A regrinding operation in a plant manufacturing molded plastic valves was studied by NIOSH. Based upon environmental air sampling measurements, analysis of work practices, and on available information regarding the toxicity of vinyl chloride, it was determined that a potential health hazard does exist. Descriptors: *Hazardous materials, *Industrial medicine, *vinyl chloride, *Carcinogens, Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres. Plastics, Valves, Moldings Identifiers: ^Occupational Safety and Health Act of 1970, *Toxic hazards. Air sampling, NTISHEWOSH PB-249 389/8ST NTIS Prices: PCS3.50/MFS2.25 } .42 ucc 042771 Health Hazard Svaluation/Toxicity Determination Report h.h.e. 75-1-19U National Inst. for Occupational Safety and Health, Cincinnati, Ohio. (390 766) Final rept. Ottawa, Melvin T. C6103I4 Fid: 06j, 061, 570, 94D, May 75 6p Rept No: NIOSH-TK-HHE-75-1- 194 Monitor: 18 See also pb-249 375. 68G G3AI7608 Abstract: An extrusion operation for wire cable was studied by NIOSH to evaluate employee exposure to vinyl chloride. It was determined that vinyl chloride gas may be potentially toxic at the concentrations measured during the NIOSH evaluation. This determination was based on exposure times, work practices, and the carcinogenic potential of vinyl chlorida. Descriptors: ^Hazardous materials, ^Industrial medicine, *Vinyl chloride, *Carcinogens, *Cables(Ropes), Toxicity, criteria, inspection , standards. Recommendations, Industrial hygiene, industrial atmospheres. Plastics, Wire, Extrusions, Exposure Identifiers: ^occupational Safety and Health Act of 1970, *Toxic hazards, NTISHEWOSH PB-249 374/OST N7IS Prices: PCS3.50/MFS2.25 43 i irr 042772 Health Hazard Svaluation/Toxicity Determination 74-134-193, PHC Industries, Inc., Camden, New Jersey Report H.H.E. National Inst, for Occupational Safety and Health, Cincinnati, Ohio. (390 766) Final rept. Gilles, Dawn C6103I3 Pld: 06J, 06T, 570, 94D, Hay 75 6p Rept No: NIOSH-TR--HHE-74-13U-193 Monitor: 18 See also PB-249 374. 68G GBAI7608 Abstract: NIOSH conducted a health hazard evaluation at a plant which manufactured handles from pvc resins. On the basis cf environmental sampling conducted at the molding and extrusion processes, it was determined that a health hazard from exposure tc vinyl chloride monomer did not exist at the time of this evaluation. Descriptors: ^Hazardous materials, *Industrial medicine, *Viryl chloride, *Polyvinyl chloride, ^Carcinogens, Toxiciry, Criteria, Inspection, Standards, Recommendations, Industrial hygiene, Industrial atmospheres, Extrusion, Exposure, Holdings, Polymers Identifiers: ^Occupational Safety and Health Act of 1970, *Tcxic hazards. Air sampling, NTISHEWOSH PB-249 373/2ST NTIS Prices: PCS3.50/MFJ2.25 VC-PVC Crisis: A Systematic Approach to Toxicological Problems California Bniv., Berkeley Kland, .1, J. A7265F3 Fid: C6T, 57? Aug 75 34p Rept No: CONF-750673-3 Contract: w-7405-ENG-48 Monitor: 18 Laurence ERA01G4 Berkeley Lab. (1112800) Abstract: For abstract, see ERA 01 04, number 05829. Descriptors: (*PVC, ^Health hazards), (*Vinyl monomers. Health hazards ) , (^carcinogens, Health hazards), (*Organic chlorine compounds. Health hazards). Biological effects. Carcinomas, Human populations. Neoplasms, Reviews, Toxicity Identifiers: SRDA/560306, NTISERDA LBL-3275 NTIS Prices: PC$4.00/MFS2.25 r'O AVA!!_A=1JZ Epidemiology Studies. Task III. Vinyl Chloride American Public Health Association, Washington, D.C.*Environmental protection Agency, Washington, D.C. Office of Toxic Substances. Final rept. AUTHOR: Landau, Emanuel, Brinkman, Charles P., C5875H1 FLD: 06J, 57U, 68G* 0SGBDB7605 Nov 75 106p* CONTRACT: EPA--68-01-2490 MONITOR: EPA/560/6-75/00 2 Hanos, Nicholas E. ABSTRACT: Osing data from the 1970 Census of Population estimates of the number of people living within a 5 mile radius of industrial plants producing vinyl chloride and vinyl chloride resins was prepared. Findings are reported. The sex, and age characteristics are provided. DESCRIPTORS: ^Epidemiology, Vinyl chloride, Industrial medicine, Public health. Vinyl chloride resins. Industrial plants. Exposure, Populations, Demography, Tables(Data), Environments IDENTIFIERS: NTISEPA0T5 PB-248 426/9ST NTIS Prices: PC$5.50/HFJ2.25 46 UCC 0-42775 Health Hazard jvaluation/Toxicity Determination Beport 74-151-181 Western Forge Crrporation, Colorado Springs, Colorado National Inst, for Occupational Safety and Health, Cincinnati, Ohio. (390 766} Final rept. AUTHOH: Butler, George J. C5793I1 FLD: 06J, 06T, 57D, 94D, Apr 75 7p SEPT NO: NIOSH-TR-HHE-74-151-181 MONITOR: 18 68G 0SGRDR7604 ABSTRACT: NIOSH conducted an enTironmental survey of a forge manufacturing hand tools. Employees sere exposed to vinyl chloride gas in the assembly and packing area arising from the vinyl chloride coating applied to packing containers. It vas determined that employees sere exposed to potentially toxic levels of vinyl chloride at the tine of this evaluation. Recommendations sere made regarding reduction of airborne concentrations and the use of respiratory protective equipment. DESCRIPTORS: ^Hazardous materials, ^Industrial medicine, *Vinyl chloride, *Polyvinyl chloride. Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres , Protectors, Exposure, Forging, Thresholds (Perception), Toxic tolerances. Films, Packaging materials. Respirators IDENTIFIERS; *Occupational Safety and Health Act of 1970, *Toxic hazards, Metalworking industry, Haximum permissible exposure. Air sampling, NTISHEWOSH PB-246 497/2ST NTIS Prices: PC$3.50/HFS2.25 47 ucc 042776 Health Hazard Evaluaticn/Toxicity Determination Report 74-149-180, protecto Wrap Company, D nver, Colorado National Inst, for occupational Safety and Health, Cincinnati, Ohio. (390 766) Final rept. AUTHOR: Butler, George J. C5793H4 FLD: 06J, 06T, 570, 94D, Apr 75 7p REPT NO: NIOSH-TR-HHS-74-149--180 aONITOS: 18 68G OSGBDS7604 ABSTRACT: The environmental survey of a plant manufacturing a polyvinyl chloride backed material by NIOSH investigators revealed potentially hazardous levels of vinyl chloride gas. It was recommended that airborne concentrations of vinyl chloride be reduced to non-detectable levels and that respirators be worn by exposed employees until control measures are effective. DESCRIPTORS: "Hazardous materials, "Industrial medicine, "Vinyl chloride, "Polyvinyl chloride. Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres , Exposure, Evaluation, Plastics industry. Respirators, Gases, Surveys IDENTIFIERS: "Occupational Safety and Health Act of 1970, "Toxic hazards. Air sampling, NTISHEHOSH PB-246 496/4ST NTIS Prices: PCS3.50/MFS2.25 48 ucc 042777 Health Hazard Evaluation/Toxicity Determination Report 74-96-173, Hichdel Corporation, Carson City, Nevada National Inst, for Occupational Safety and Health, Cincinnati, Ohio. (390 766) Final rept. AUTHOR: Okawa, Melvin T. C5793H2 FLD: 06J, 06T, 570, 94D, Feb 75 8p REPT NO: NIOSH-TR--HHE-74-96--173 MONITOR: 18 68G 0SGRDB7604 ABSTRACT: A plant involved in injection molding of polyvinyl chloride was studied by NIOSH to evaluate employee exposures to vinyl chloride and trichloroethylene, which is used as a degreaser. It was determined that a potential health hazard from exposure to vinyl chloride did exist in the Regrind Room, and a potential hazard may also exist in the injection molding areas. Trichloroethylene was judged to be not toxic at the concentrations measured at the degreasing operation. DESCRIPTORS: *lnjection molding, Hazardous materials, ^Industrial medicine, Vinyl chloride, *Polyviayl chloride, *Chlorohydrocarbons, Degreasing, Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres. Respirators, Exposure, Protectors, plastics industry. Evaluation, Toxic tolerances, Thresholds(Perception), Surveys, Gases IDENTIFIERS: Occupational Safety and Health hazards, Ethylene/trichloro, Air sampling. exposure, NTTSHEWOSH Act of 1970, *Toxic Maximum permissible PS-246 494/9ST NTIS Prices: PC$3.50/MFS2.25 49 WHTT ucc 042778 Health Hazard Evaluation/Toxicity Determination a port 74-89-189, Hew Tort Telephone and Telegraph company. New Tori, N.T National Inst, for Occupational Safety and Health, Cincinnati, Ohio. (390 766) Final rept. AUTHOR: Straub, Wesley E. C5793H1 FX.D: 06J, 06T, 570, 94D, Apr 75 7p BEPT NO: NIOSH-TH--HHE--74-89-1 89 HONITOB: 18 68G OSGRDB7604 ABSTBACT: NIOSH conducted an environmental survey to determine employee exposure to vinyl chloride, styrene, benzene, and hydrogen chloride during the application of heat shrinkable tape to telephone cables. It was determined that air concentration levels were b low detectable levels for all substances tested and therefore were judged to be not toxic under the conditions noted during this evaluation. DESCRIPTORS: ^Hazardous materials, Industrial medicine, *Styrene, Benzene, Hydrogen chloride, Vinyl chloride. Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres. Evaluation, Exposure, Coatings, Polyvinyl chloride, Thresholds(Perception), Toxic tolerances IDENTIFIERS: Occupational Safety and Health Act of 1970, Toxic hazards. Air sampling, Maximum permissible exposure, NTISHEWOSH PB-246 493/1 ST NTIS Prices: PCS3.50/HF$2.25 !JCC *2775 Health Hazard Evaluation/Toxicity Determination Report 74-85-185, H. H. Gall Company, Lancaster, Pennsylvania National Inst, for Occnpational Safety and Health, Cincinnati, Ohio. (390 766) Final rept. AUTHOR: Straub, Wesley E. CS793G4 FLD: 06J, 06T, 570, 94D, Apr 75 lOp REPT NO: NIOSH-TR-HHE-74-85-185 MONITOR: 18 68G 0SGBDR7604 ABSTRACT: A health hazard survey was conducted by NIOSH to investigate a potential health hazard at a company performing lamination of printed material on a job basis. The laminate is a polyvinyl chloride based product which is layered with the printed material, then the layers are heated for curing. It was determined that a potential health hazard exists at the lamination press from vinyl chloride gas, based on environmental measurements, observation of work practices and a review of past medical reports* DESCRIPTORS: *Hazardous materials, *lndustrial medicine, *Vinyl chloride, *Polyvinyl chloride. Toxicity, Criteria, inspection. Standards, Recommendations, Industrial hygiene. Industrial atmospheres , Exposure, Evaluation, Gases, Laminates, Carcinogens, Liver, Thresholds(Perception), Toxic tolerances, ventilation. Surveys IDENTIFIERS: *Occupational Safety and Health Act of 1970, *Toxic hazards. Lamination, Air sampling. Cancer, Maximum permissible exposure, NTISHEWOSH PB-246 492/3ST NTIS Prices: PCS3.50/MFS2.25 5I I. ICC 042780 Health Hazard Evaluation/Toxicity D termination R port 74-71-142, Delco Remy Division, Anaheim, California National Inst, for Occuoational Safety and Health, Cincinnati, Ohio. (390 766) Final rept. AUTHOR: OXawa, Melvin T. C5793G1 FLD: 06J, 06T, 57U, 94D, Sep 74 5p REPT NO: NIOSH-TR-HHE--74-71-142 MONITOR: 18 68G OSGRDR7604 ABSTRACT: An operation in which polyvinyl chloride was being used to manufacture the separators used in automobile batteries was studied by NIOSH investigators. It was determined that vinyl chloride vapors were not toxic at the concentrations measured during normal operating conditions. This determination was based upon the environmental levels of chloride, the conditions of use of polyvinyl chloride, and current information available on the toxicity of vinyl chloride. DESCRIPTORS: ^Hazardous materials, ^Industrial nedicine, *vinyl chloride, *Battery separators. Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres , Vapors, Exposure, Evaluation, Electric batteries IDENTIFIERS: voccupational Safety and Health Act of 1970, *Toxic hazards. Battery industry. Air sampling, NTISHEWOSH PB-246 489/9ST NTIS Prices: PC$3.50/HFS2.25 52 Ucc 042781 Health Hazard Evaluation/Toricity Determination Heport 74-29-161, Ethyl Visgueen Division of Ethyl Corp., Terre Haute, Indiana National Inst, for Occupational Safety and Health, Cincinnati, Ohio. (390 766) Final rept. AOTHOR: Butler, George J., Bodner, Arnold H, C5793E2 FLD: 06J, 06T, 570, 94D, 68G USGBDE7604 Nov 74 lOp EEPT NO: NIOSH-TR-HHZ-74-29-161 MONITOR: 18 ABSTBACT: A manufacturer of polyvinyl chloride pipe was investigated by NIOSH to evaluate worker exposures to polyvinyl chloride. Crystals of polyvinyl chloride resin are mixed with other materials and then extruded into pipe. Air samples were collected, workers were given medical interviews, and blood samples were taken to be analyzed for serum glutamic-oxaloacetic transaminase. ,It was determined that a health hazard from vinyl chloride monomer did not exist at the time of the survey but that a potential carcinogenic hazard did exist in th blending room areas of the plant. DESCRIPTORS: ^Hazardous materials, *lndustrial medicine, *Polyvinyl chloride, *vinyl chloride. Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres. Evaluation, Surveys, interviews. Blood analysis. Pipes(Tubes), Carcinogens, Plastics industry. Dust, Statistical data. Chemical ind ustry IDENTIFIERS: *0ccupational Safety and Health Act of 1970, vToxic hazards. Air sampling, NTISHESOSH PB-246 482/4ST NTIS Prices: PCS3.50/HFS2.25 53 1 ICC 042782 Toxicology of Plastic Devices Having Contact with Blood Children's Hospital Medical Center, Boston, Mass.* National Heart and Lung Inst., Bethesda, Md. (082 790) Comprehensive rept. Sep 72-Sep 75 AUTHOR: Kevy, Sherwin v., Button, Lawrence N., C5751F1 FLD: 06T, 131, 06L, 57T*, 710, 95c Oct 75 112 p* CONTRACT: PHS-72-2968 MONITOR: NIH/NHLI-72-2969-CR See also PB-244 753. Jacobson, May USGBDR7603 S. ABSTRACT: The objectives of this research were twofold: (1) the utilization of an animal model to evaluate the functional effect of Di-2-ethylhexylphthalate (DEHP) accumulation, and (2) the development of an in vitro testing procedure that could be correlated with the animal studies. The rate of extraction of DEBP from polyvinyl chloride (PVC) is dependent upon both the temperature during storage and the lipid content of the medium. DEHP so obtained is in true solution, with particle sizes less than 0.22 micron. Tissue culture studies demonstrate that solubilized DEHP in varying concentrations inhibits the growth and ultimately kills human diploid fibroblasts. PVC and siliconized glass transfused rhesus had abnormalities in liver histopathology and liver functions for up to 14 months following cessation of transfusions. DEHP or silicon persisted in the tissues for up to 14 months post-transfusion. Both the control rhesus and those transfused with platelets processed in polyethylene containers were normal. DESCRIPTORS: ^Plastics, ^Toxicology, *Polyvinyl chloride. Blood, In vitro analysis. In vivo analysis. Tissue culture. Body fluids. Blood plasma. Blood serum. Blood cells. Plasticizers, Polymers, Blood transfusion. Liver, Spleen, Tissues(Biology) , Histology, Pathology, Monkeys, Experimental data. Accumulation IDENTIFIERS: *Biomaterials, *Blo<* compatible materials. Animal models , *Phthalic acid/bis(ethylhsxyl-ester), Histopathology, Bioaccumulation, NTISNIHHLI PB-247 168/8ST NTIS Prices: PCS5.50/HFS2.25 54: 11 or 042783 Recommended standard for Occupational Exposure to Vinyl Chloride National Inst, for Occupational Safety and Health, Rockville, 407 192) C5674J3 FLD: 06J, 06T, 570, 94D, 68G OSGRDR7602 1975 10p MONITOR: 13 See also PB-246 692. ad. ( ABSTRACT: The report includes: Background (events and toxicological finds) of the standard; scope and application; definitions of terns; requirements for regulated areas; routine operations; reactor and vessel entry; maintenance and decontanination; hygiene measures; signs; information and training; environmental monitoring and record keeping; reports; medical surveillance. Despite the fact that animal experiments have shown no liver tumors at atmospheric concentrations of 50 ppm, the concept of an allowable working level is rejected. Since there is measurable concentrations of vinyl chloride personnel should wear an air-supplied respirator .because chemical cartridge respirators do not afford adequate protection against vinyl chloride vapors. DESCRIPTORS: *Ha2ardous materials, *Industrial medicine, *vinyl chloride. Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Industrial atmospheres, chloronydrocarbons. Chlorine alaphatic compounds. Protection, Safety, Requirements, Evaluation, Carcinogens IDENTIFIERS: ^Occupational Safety and Health Act of 1970, *Toxic hazards. Air sampling, NTISHEHOSH PB-246 691/0ST NTIS Prices: PCS3.50/HFS2.25 55 iVirr'w- Registry of Toxic Effects of Chemical Substances. 1975 Edition National Inst, for occupational Safety and Health, Rockville, AUTHOR: Christensen, H. E., Luginbyhl, T. T., Carroll, B C5673A3 FID: 06T, 06J, 577*, 57U, 68G* USGRDR76Q2 Jun 75 1399p* REPT NO: NIOSH-TSL-75 CONTRACT: PHS-CDC-99-74-92 MONITOR: 18 Md. ABSTRACT: The 1975 Edition of the Registry of Toxic Effects of Chemical Substances, formerly known as the NIOSH Toxic Substances List, is the fifth Edition prepared in compliance with the requirements of the Occupational Safety and Health Act of 1970 (PL-91-596). This Registry contains toxicity information on approximately 17,000 unique chemical substances along with about 48,000 synonyms. Information is given on route of entry, toxic dose and toxic effects including an indication of existing evidence of the substance may be carcinogen, mutagen, teratogen, etc. DESCRIPTORS: *Toxicity, *Chemical compounds, *Hazardous materials. Indexes(Documentation), Public health. Dosage, Industrial medicine. Standards, Chemical properties. Exposure, Asbestos, Pesticides, Carcinogens, Vinyl chloride. Mutagens, Aquatic animals. Toxicology IDENTIFIERS: Occupational safety and Health Act of 1970, Maximum permissible exposure. Teratogens, *Occupational safety and health, NTISHEWOSH PB-246 557/3ST NTIS Prices: PCS41.75/HFS2.25 56' ucc 042785 The Physiological and Toxicological Aspects of Smoke Produced During the Combustion of polymeric Hat rials Utah Oniv., Salt Lake City. Flammability Research Center.*National Science Foundation/ Washington, D.C. Research Applied to Rational Needs. Annual rept. 1972-73 AUTHOR: Einhorn, I. N., Birky, N. H., Grunnet, H. L., Packham, S. C.f Petajan, J. H. C5384L3 FLD: 06T, 06P, 57T, 57S, 71 USGHDB7524 24 Sep 73 160p SEPT NO: FRC/UU-12, UTEC-73-161 GRANT: NSF-GI--33650 MONITOR: NSF/RA/E-73-196 I ABSTRACT: A study was undertaken at the Flaamability Research Center of the University of Utah to determine the physiological and toxicological effects of saoke. Four classes of materials were selected for study: cellulosics, urethanes, polyvinyl chlorides, and Douglas fir. Smoke chambers and animal exposure chambers were developed for the analysis of saoke and its components and the observation of effects of combustion products on animals. The effects of combustion products on survival response in rats were measured, and toxicological studies of rats under exposure to saoke were made. The effects of combustion on the eyes of the animals are the subject of continuing experimentation. Small-scale laboratory fire experiments are being correlated with full-scale fire tests conducted at the National Bureau of Standards. Selected case histories of fire injuries are being studied to determine the medical history of victims until recovery. DESCRIPTORS: *Toxicology, ^Combustion products. Flammability, Materials, Saoke, Fumes, Physiological effects. Responses, Experimental data. Laboratory animals. Hats, Polyvinyl chloride, Chemical analysis. Urethanes, Injuries, Cellulose, Fir wood IDENTIFIERS: NTISNSFRA PB-244 876/9ST NTIS Prices: PC $ 6.2 5/HF $2.25 57 UCC 'l<f27p,F; Toxicology of Plastic Devices Having Contact with Blood Utah univ., Salt Lake City. Dept, of Applied Pharmaceutical Sciences,National Heart and Lung Inst., Bethesda, Md, Annual rept. 1 May 74-30 Apr 75 AUTHOR: Petersen, Robert v., Lyman, Donald J., Roll, Swinyard, Ewart A. C5332D3 FLD: 06T, 06L, 57Y*, 95A, 95C USGRDR7523 1 May 75 116p CONTRACT: PHS-73-2908 MONITOR: NIH/NHLI-72-6 See also PB-233 701. David B., ABSTRACT: The project is concerned with toxicological evaluation of polyvinyl chloride (PVC) and, more specifically, the commonly used plasticizer, di-(2-ethylhexyl) phthalate (DEHP). Selected findings indicate that (1) the acute and subacute LD5Q of a metabolite of DEHP (mono-(2-ethylhexyl) phthalate) given intravenously or intraperitoneally in mice or rats is highly toxic and irritant. (2) Analysis of particle size distribution of DEHP dispersed in fetal calf serum by sonication indicates that the vast majority of particles are less than 2 microns diameter. (3) DEHP appears to have some effect on chromosomes in human leukocytes and human fetal lung cells in tissue culture. (4) DEHP prolongs hexobarbital sleep. Phthalate-contaminated sheets caused greater adhesion and aggregation of platelets than methanol-cleansed PVC when exposed to sheep blood in ex-vivo experiments. DESCRIPTORS: *Polyvinyl Toxicology, Lethal dosage. animals. Tissue culture. supplies. Mechanical organs chloride, Pathology, Bioassay, Plastics, Plasticizers, Body fluids. Blood, Laboratory Humans,. phthalates. Medical IDENTIFIERS: Blood compatible materials. Biomaterials, Phthalic acid/bis(ethylhexyl-ester), NTISNIHHLI PB-244 753/0ST NTIS Prices: PC$5.25/MF$2.25 58 jJCC 042787 Three Week Intravenous Administration in the Dog DI (2 - Ethylhexyl) Phthalate Hazleton Labs. America, Inc., Vienna, Va.`National Heart and Lung Inst., Bethesda, Md. Final rept. 9 Jul 74-28 Feb 75 AUTHOR: Rutter, Henry A. Jr C5254F1 FLD: 06Tr 57Y USGSDR7522 9 Apr 75 55p CONTRACT: NO1-HB-2-2991 MONITOR: 18 Sponsored in part by National Heart and Lung Inst,, Bethesda, Md. See also PB-224 376. ABSTRACT: A repeated dose of approximately 0.50, 0.75, and 1.4 mg/kg/day of di(2-ethylhexyl) phthalate in canine plasma was administered to beagles for 21 days. No consistent compound-related alterations were observed in animal behavior or hematological and clinical chemical parameters. Terminal body weights, organ weights, and organ/body weight ratios were acceptable normal limits and comparable to control values. Compound-related histomorphologic alterations were not observed in dogs receiving various concentrations of di(2-ethylhexyl) phthalate leached from PVC blood bags during storage. DESCRIPTORS: `Toxicity, `Phthalates, `Plasticizers, Dogs, Bioassay, Laboratory animals. Dosage, Medical equipment. Medical supplies. Tables (Data), Experimental data. Animal behavior. Histology, Morphology, Polyvinyl chloride. Pathology IDENTIFIERS: Biomaterials, NTISNIHH1I PB-244 262/2ST NTIS Prices: PCS4.2S/MFS2.25 59 uec 042788 Ambient Air Measurements of Vinyl Chloride in the Niagara Palls Area National Environmental Research Center, Research Triangle Part, N.C. chemistry and Physics Lab, Environmental monitoring series AUTHOR: Gay, Bruce , Jr, Noonan, Richard C. C5175A3 ?LD: 13B, 07A, 06F, 68A, 99B, 57U May 75 19p REPT NO: EPA/650/4-75/020 PROJECT: EPA-80AP-21AKC MONITOR: 18 USGRDR7521 ABSTRACT: A 6-day survey was conducted in the Niagara Falls area to determine the concentration of vinyl chloride in the atmosphere. Samples vere obtained in a residential area adjacent to the chemical plants where vinyl chloride emissions were suspected, in areas around the plants, and in other areas of Niagara Falls, The highest concentration of vinyl chloride measured was 40 ppb for a 5-hour integrated sample observed at a residential area two blocks east of a vinyl chloride polymerization plant. Grab samples taken downwind of chemical plants exhibited a high of 28 ppb. samples taken from downtown Niagara Falls and upwind north of the chemical plants contained no detectable vinyl chloride. The areas surrounding the chemical plants, including the adjacent residential areas, are also affected by emissions into the atmosphere of chlorine and other halogenated compounds as exhibited by the deterioration of metal surfaces, particularly aluminum windows and doors. DESCRIPTORS: *Air pollution, *Vinyl chloride, Chemical plants. New York, Angiosarcomas, Chlorine organic compounds, Halohydrocarbons, Aluminum, Buildings, Corrosion, Sampling, Public, health IDENTIFIERS: Air quality, Niagara ?alls(New York), *Air pollution sampling. Air pollution effects (Materials), Air pollution effects(Humans) , NTISEPAORD PB-243 695/4ST NTIS Prices: PC$3,25/MFJ2.25 60 uec 042789 A Framework for the control of Toxic Substances (A Compilation of Speeches) Environmental Protection Substances. AUTHOR: Schweitzer, Glenn C5104A1 FLD: 06T, 06J, Apr 75 57p REPT NO: EPA/560/4-75-004 MONITOR: 18 Agency, E. 68G, 68A, Washington, D.C. 68D, 57T, 57U, 99 Office of Toxic USG2DR7520 ABSTRACT: This collection of speeches in large measure reflects the evolution of the interests, policies, and programs of the Office of Toxic Substances from April 1973 to March 1975. The speeches deal with questions that are of broad national concern: the identification of chemical hazards, the need for development of toxicological and other data on chemicals, the pending Toxic Substances Control Act, and need for regulation to control toxic chemicals. DESCRIPTORS: ^Public health, ^Toxicology, *Environmental impacts, ^Industrial medicine. Environmental surveys. Government policies. National government, legislation. Economic impacts. Inorganic compounds, organic compounds. Vinyl chloride. Regulations, Decision making. Hazards IDENTIFIERS: *Hazardous materials. Toxic Substances control Act, NTISEPAOTS PB-243 459/5ST NTIS Prices: PC$4.25/HFS2.25 6T ucc 042790 Evaluation of Vinyl Chloride Associated with Heat Sealing PVC Products Environmental Health Lab Mcclellan APB Calif (407609) Final rept. AUTHOR: Smith, Billy S,, Burnett, Ronald D., Diamond, Philip, Greathouse, Jack E. C4745P3 FLD: 6J, 570 0SGRDR7515 Dec 74 70p REPT NO: SHL-74M-17 PROJECT: HAF-351 MONITOR: 18 ABSTRACT: potential vinyl chloride (VC) exposures were evaluated during neat packaging and during welding operations using heat to join polyvinyl chloride (PVC) sheets or film. The potential for VC exposure was evaluated by analyzing the PVC materials for entrained or encapsulated VC and by analyzing air samples collected during the meat wrapping and welding operations for VC. The results of all analyses are shown. The potential for exposure to vinyl chloride monomer at the 0.1 ppm level was not found to exist in either of the two operations studied. No vinyl chloride monomer was detected in the PVC materials. DESCRIPTORS: ^Industrial hygiene, Exposure (Physiology), Polyvinyl chloride. processing *packaging, *Helding, Gas analysis. Heat, Food IDENTIFIERS: *Vinyl chloride. Indoor air pollution. Gas sampling, Air pollution standards, NTISDODAF AD-A009 997/8ST NTIS Prices: PC$4.25/HFJ2.25 62 uce 042791 preliminary Assessment of the Environmental Problems Associated with Vinyl Chloride and Polyvinyl Chloride Environmental protection Agency, Washington, D.C. Office of Toxic Substances. Interim rept. C4385E4 PLD: 13B, 68G* Sep 74 106p* REPT NO: EPA/560/4-74-001 HONITOR: 18 Report on the Activities Force. OSGHDH7509 and Findings of the vinyl Chloride Task ABSTRACT: The report summarizes the activities and findings of a task force to assess the character and extent of the problems associated with the production, distribution, use, and disposal of vinyl chloride and polyvinyl chloride. The first Section discusses the nature and magnitude of problems. The second discusses previous and planned activities within the Federal Government of particular significance and the role of industry. The report concludes with some specific recommendations. DESCRIPTORS: *Air pollution, *Water pollution, *Toxicity, *Vinyl chloride, *Polyvinyl chloride. Surveys, Problem solving. Health, Ecology, Tests, Industrial relations IDENTIFIERS: Air pollution abatement, NTISEPAOTS PB-239 1 10/0ST NTIS Prices: PCS5.2S/HFS2.25 63' ucc 042792 Experime.tal Data Serving as a Basis for Separat Concentrations of Dibutylphthalate permissible National Institutes of Health, Bethesda, fld. Translation Unit.* Environmental Protection Agency, Research Triangle Park, N.C. Translation Services Section, AUTHOR: Spasovski, Hincho C4045C2 FLD: 06J, 06T USGSDS7504 Jul 73 8p EEPT NO: NIH-73-370C MONITOR: EPA-TR-29-74 Trans, of Khigiena, Spidemiologiya i flikrobiologiya (Bulgaria) v7 P38-44 1964. ABSTRACT: Based on experiments using aniaals subjected to single and multiple inhalatory, oral and skincoating dosages, and which ar supported by mathematical and analogical methods, the separate permissible standard for concentrations of industrial dibutylphthalate heated above 140C is 0.001 milligrams per liter of atmosphere. The toxicity of dibutylphthalate depends upon the modality of its introduction to the organism. Most toxic are its fumes heated above 140C which penetrate and consume the lungs. The substance is weakly toxic in oral application. It does not possess skin absorptive capability. Dibutylphthalate possesses a highly cumulative effect in inhalation and ingestion. The cumulative coefficient falls just short of one, which explains the hypersensitivity associated with it. DESCRIPTORS: *Phthallates, *Toxicology, ^Plastics, ^Industrial medicine. Industrial atmospheres. Polyvinyl chloride, Bulgaria, Translations, Lung, Laboratory aniaals. Experimental data. Exposure, Permissible dosage. Fumes IDENTIFIERS: Phthallic acid/ (dibutyl-ester), Indoor air pollution, NTISEPAISD, NTISNIH PB-237 886-T/S7 NTIS Prices: PC$3,25/MFS2.25 64 LJCC 042793 I I Accumulation of DI-2-Ethylhexyl Phthalate (DEHP) in Whole Blood, Platelet Concentrates, and Platelet-Poor Plasma Naval Blood Research Lab Chelsea Mass (387481) AUTHOR: Contreras, T. J., Sheibley, R. H. , Valeri, C. R. C3611I1 FLD: 6L 0SGBDR7424 4 Sep 73 15p PROJECT: MR041.02 TASK: MR041.02.01 MONITOR: 18 Revision of report dated 30 Mar 73, See also AD-766 554, Availability: Pub. in Transfusion, v14 nl p34-46 Jan/Feb 74. ABSTRACT: The concentration of the plasticizer, di-2-ethylhexyl phthalate (DEHP), in the plasma was measured after storage of the whole blood in polyvinyl chloride plastic bags at 4C for up to 38 days in either ACD or CPD. The plasma from ACD-stored whole blood contained more DEHP than that from CPD-stored whole blood. The continuous-flow centrifugation washing procedures removed about 98 per cent of the DEHP from ACD whole blood stored for 33 days at 4C. DEHP was assayed in the platelet-rich plasma, platelet-poor plasma, supernatant of the platelet concentrate, washed platelets, and washed red blood cells prepared from CPD whole blood. Very little DEHP was found in the washed red blood cells and platelets, a small amount was found in the platelet-poor plasma, and a large amount in the supernatant of the platelet concentrate. A greater amount of DEHP accumulated in the platelet concentrates that were stored at 22C than in those stored at 4C. when platelet concentrates from CPD whole blood were stored at 22C for 72 hours, the amount of DEHP was about four times that observed after 4C storage for the same length of time. (Author) DESCRIPTORS: *Blood, `Phthalates, *Plasticizers; `Polyvinyl chloride. Plastics, Bags, Blood plasma. Blood platelets. Accumulation, Blood banks. Storage, Blood transfusion. Toxicity IDENTIFIERS: Phthalic acid/fcis(ethylhexyl-ester), NTISDODN AD-786 253/5SL NTIS Price: Reprint 66 i sor: 042*794 The Effect of Dibutyl- and Dioctylphthalates on Rats with Oral Feeding during Prolonged Testing. Part 1. application and Toxicological Properties of Dibutyl- and Dioctyl-Phthlates National Institutes of Health, Bethesda, Md. Translation Unit.*Environmental Protection Agency, Research Triangle Park, N.C. Translation Services Section. AUTHOR: Piekac2, Hanna C3994L4 FLD: 06T VSG8DB7503 1974 lOp REPT NO: NIH-73-374C flONITOR: EPA-TR-2 8-74 Trans, of Roczniki Panstwowego Zaklada Higieny (Poland) v22 p55-61 1971. ABSTRACT: The use of dibutyl- and dioctyl-phthalates is discussed a propos of legislation in various countries, as well as their toxicological properties. This study serves as an introduction to research on hyperacute and extended toxicity of both phthalates. DESCRIPTORS: vphthalates, ^Toxicology, Chemicals, Polyvinyl chloride. Manufacturing, Poland, Translations IDENTIFIERS: Phthalic acid/ (dioctyl-ester), Phthalic acid/(dibutyl-ester), NTISEPAISD, NTISNIH PB-237 885-T/ST NTIS Price: PC$3.25/HFS2.25 65- i UOr; 042795 Toxicology of Plastic Devices Having Contact with Blood Children's Hospital Medical Center, Boston, Mass* Annual rept. Sep 73-18 Jun 74 AUTHOR: Kevy, Shervin 7., Button, C3284H1 FLD: 6T, 6L, 57Y, 95A, 21 Jun 74 52p* MONITOR: NIH/HH1I-72-2969 Lawrence H., Jacobson, 95C USGRDH7419 May S. ABSTRACT: Continued studies are presented that evaluate the possible toxicological effect of Dl-2-ethylhexyl phthalate (DEHP) extracted from poly-vinyl chloride (PVC) plastic by blood and biologic fluids. Specific studies are outlined in four areas: The preparation of an antibody to phthalate in rabbits for use in inmuno-fluorescent studies and a radioimmunoassay for detection of phthalate; bi-weekly platelet transfusions after storage for 48 hours at 4 and 22C in PYC, polyethylene and siliconized glass is a natural and clinically oriented method of phthalate administration; evaluation of these animals for hepatic, splenic and pulmonary functions by means of nuclear medicine techniques, liver function tests and compartmental BSP analysis; tissue analysis of tranfused and non-transfused patients for DEHP; and quantitative analysis of liver tissue for DEHP of multi-transfused Rhesus monkeys. DESCRIPTORS: *Plastics, ^Toxicology, * Plasticizers, * Polyvinyl chloride. Blood, Tissue culture. Medical supplies. Mechanical organs. Experimental data. Antibodies, Phthlates, Bioassay, Humans, Laboratory animals. Blood transfusion IDENTIFIERS: *Blood compatible materials, acid/bis (ethylhexyl-ester) , Biomaterials, NTISHESHLI *Phthalic PB-233 857/2 NTIS Prices: PCJ5.75/HF51.45 67 ucc 042796 Toxicology of Plastic Devices Having contact with Blood Utah Univ.f Salt Lake City. Coll, of Pharaacy. Interim rept. 24 Aug 72-1 May 74 AUTHOR: Lyman, Donald J., Boll, David B., C3283I1 FLD: 6T, 6L, 57Y*, 95A*, 95C May 74 206p* GRANT: PHS-73-2908 MONITOH: NIH/NHLI-73-2908-B Swinvard, Ewart A. USGBDB7419 ABSTRACT: The project is primarily concerned with toxicological evaluation of polyvinyl chloride and, more specifically, the conaonly used plasticizer, di (2-ethylhexyl) phthalate (DEHP). Evaluations are concentrated on long range, subtle toxicity potential, although basic acute and subacute studies are also utilized* Plastic composition studies, acute toxicity studies, tissue culture studies, subacute toxicity studies, metabolite identification, teratogenic studies, neurologic studies, larger aniaal studies, analyses of human blood exposed to plastics during hospital procedures, and possible statistical analysis of human patients following extensive exposure of blood to plastics are includad. Selected findings indicate that: Plastic components which contain DEHP as a plasticizer are toxic to L-929 cells in tissue culture; DEHP appears to prevent implantation of fertilized ova in rats and mice; DEHP affects rate and amplitude of contractions in isolated rat hearts; DEHP is hydrolyzed in vitro by liver microsomes and mitochondria but not by cytosol. DESCRIPTORS: *Polyvinyl chloride, Plasticizers, Blood, Medical supplies. organs. Experimental data, Phthalates, Bioassay, Neurology Plastics, ^Toxicology, Tissue culture. Mechanical Laboratory animals. Humans, IDENTIFIERS: Blood compatible materials, acid/bis (ethylhexyl-ester), Biomaterials, NTISHEHHLI Pathalic PB-233 701/2 NTIS Prices: PCJ5.75/MFS1.45 68 ucc 042797 Dynamics of Hygenic working conditions and occnpational Disease Incidence among workers in Saspension Polyvinyl Chloride Production over a Number of Tears National Institutes of Health, Bethesda, Hd. Translation AUTHOR: Filatova, 7. S., Antonyuzhenko, V, A. C321UA2 FLD: 6J, 6T USGRDR7418 Jul 74 7p SEPT NO: NIH-74-352C MONITOR: 18 Trans, of Gigiena Truda i Professionalnye zabolevaniya p32-34 1971. Unit. (USSR) v15 n4 ABSTRACT: The occupational disease incidence in workers resulting from vinyl chloride air pollution was studied over a period of 17 years (1953-1969). Although industrial conditions have improved, there still occurs new cases of chronic occupational poisoning. Various clinical manifestations of chronic vinyl chloride poisoning, as a function of environmental air pollution have been established* A series of measures designed to improve air quality in work areas is suggested. DESCRIPTORS: ^Industrial hygiene, ^Occupational diseases, *Industrial atmospheres, vpolyvinyl chloride. Air pollution. Toxicity, Toxic diseases, USSR, Translations IDENTIFIERS: Air quality, NTI5NIH, NTISHEWIHL PB-233 614-T NTIS Prices: PC$4.00/HFJ1.45 69 ucc 042788 Health Hazard Evaluation/Toxicity Determination. John Morrell Company/ Sioux Falls, South Dakota National Inst, for Occupational Safety and Health, Cincinnati, Ohio. (390 766) Final rept. Oct 72-Jan 73 AUTHOR: Polakoff, Phillip L., Vandervort, Robert C3084E2 FLD: 6J, 6T, 570, 94D, 68G USGBDR7416 Oct 73 15p REPT NO: NIOSH-TR-089-74, HHE-71-29-89 MONITOR: 18 ABSTRACT: In response to a request received from a representative of employees, the National Institute for Occupational Safety and Health (NIOSH) conducted a health hazard survey to evaluate exposure to thermal decomposition products of polyvinyl chloride meat packaging film at John Morrell Company, Sioux Falls, South Dakota. Based on medical evidence compiled during a limited study of neat wrapping employees it was determined that air contaminants generated by the thermal cutting of polyvinyl chloride packaging films in conjunction with the wrapping of meat are potentially toxic to some meat wrapping employees. Symptoms range from mild eye, nose and throat irritation to more serious respiratory problems for meat wrappers who have an underlying predisposition to respiratory difficulties. Recommendations have been suggested to management regarding preemployment examinations and work practices. DESCRIPTORS: ^Hazardous materials, ^Industrial medicine, *Polyvinyl chloride. Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Packaging, Pyrolysis, Respiratory infections IDENTIFIERS: *Occupational Safety and Health Act of 1970, Packaging materials, *Meat packing industry, *Toxic hazards. Air pollution effects(Humans), NTISNIOSH PB--232 578/5 NTIS Prices: PC$4.00/MFS1.45 70 ucc 042799 Health Hazard Evaluation/Toxicity Determination. Seattle, Washington National Inst, for Occupational Safety and Health, Cincinnati, Ohio. (390 766) Final rapt. Aug 72-Jan 73 AUTHOR: Polakoff, Phillip L., Vandervort, Hobert C2705I4 FLD: 6J, 570, 57T, 94D, 68G 0SGHDH7411 Sep 73 23p SEPT NO: NIOSH-TR-Q70-74, HHE-72-53-70 HONITOS: 18 Also includes Sept, nos, HHE-72-54-71 thru HHE-72-58-75. ABSTBACT: In rsponse to a received from a representative of employees the National Institute for Occupational Safety and Health (NIOSH) conducted a health hazard survey to evaluate exposure to thermal decomposition products a polyvinyl chloride (PTC) meat packaging film at six retail grocery companies in the Seattle, Washington area. Based on medical evidence compiled during this limited study of meat wrapping employees it was determined that air contaminants generated by the thermal cutting of polyvinyl chloride packaging films in conjunction with the wrapping of meat are potentially toxic to meat wrapping employees. Symptoms range from mild eye, nose and throat irritation to more serious respiratory problems for meat wrappers who have an underlying predisposition to respiratory difficulties. Recommendations have been suggested to management regarding pre-employment examinations and work practices. DESCRIPTORS: ^Hazardous materials, ^Industrial medicine, 'Polyvinyl chloride. Toxicity, Criteria, Inspection, Standards, Recommendations, Industrial hygiene. Pyrolysis, Packaging, Hazards, Respiratory diseases. Air pollution IDENTIFIERS: 'Occupational Safety and Health Act of 1970, NIOSH PB-229 709/1 NTIS Prices: PC44,25/BFJ1.45 N 7'H ' uco 042800 Coal nine combustion Products: Identification and Analysis Ultrasysteas, Inc., Irvine, Calif. (407 617) Annual rept, FY 1972-73 AUTHOR: Paciorek, K. L., Kratzer, R. H., Kaufaan, J., Nakahara, J. H. C2314G2 FLD; 7D, 21B, 81, 111, 11L, 48A, 710, 99F, 81A, 71R USGRDR7406 Aug 73 160p REPT NO: SN-8220/A1 CONTRACT: HOI 33004 HONITOR: Euflines-OFR-8-74 ABSTRACT: The toxic products formed during theraal oxidative degradation of neoprene and polyvinyl chloride coapositions, urethane foams and various untreated and treated woods were determined quantitatively on a g/g basis. Quiescent and dynaaic decomposition conditions were employed. Analyses were performed using high vacuum separations, gas chromatography, aass , spectrometry, infrared spectroscopy, and wet chemical methods. The main toxic species found were among others CO, HC1, BCN, S02, anhydride, aniline, and furfural. Thermograviaetric analyses were performed on all the coapositions, and the data were correlated to available formulating inforaation and product formation. DESCRIPTORS: ^Combustion products, *Plastics, *Wood, *Coal mining, Nining equipment, Chloroprene resins. Polyvinyl chloride. Polyurethane resins. Carbon monoxide. Decomposition reactions. Hydrogen chloride. Sulfur dioxide. Hydrogen cyanide. Anhydrides, Anilines, Furfurals, Toxicity, Theraal analysis. Gas chromatography, Hass spectroscopy. Chemical analysis. Oxidation, Safety, Organic coapounds IDENTIFIERS: BH PB-226 944/7 NTIS Prices: PC$11.00/HFS1.45 72 ucc 042801 A Toxicological Evaluation of Certain Heparin-Quaternary Ammonium Complexes Battelle Columbus Labs., Ohio. (407 080) Annual rept. 1 Oct 72-30 Nov 73 AUTHOR: Grode, G. A., Crowley, J. P., Falb, B. D., Leininger, B. I. C2313K1 FLD: 6T, 6L, 7C, 57Y*, 95A*, 99C 0SGRDB74Q6 26 Dec 74 33p* CONTRACT: PHS-73-2918 MONITOR: 18 ABSTRACT: physical and chemical characterizations show that the heparin-quaternary ammonium salt complexes can be reproducibly prepared from a given lot of a quaternary ammonium salt. Local toxicity studies also indicate that both the tridodecyl methyl ammonium chloride-heparin and tricapryl methyl ammonium chloride-heparin complexes elicit qualitatively similar responses, while quantitatively, the TCM AC-he par in .complex produced a locally more severe response. Single-dose toxicity studies of the heparin complexes, carried out in mice, show that the TDBAD-heparin complex is the more toxic with an LD50 value of 3.3 mg/kg, as compared to an LD50 of 195 mg/kg for the TDMAC-heparin complex. This toxicity gradient is perhaps the reflection of increasing solubility of the complexes in the biological medium with the (C9) capryl-based heparin complex (TCMAC-heparin) being the most soluble. Experimental evidence indicates that the toxicity of TDMAC-heparin treated poly (vinyl chloride) devices is very low. DESCRIPTORS: *Heparin, ^Mechanical organs, ^Mechanical hearts. Surface properties. Toxicology, Blood plasma. Plastic coatings. Ammonium compounds, polyvinyl chloride. In vitro analysis. Anticoagulants, Surface chemistry IDENTIFIERS: *Quaternary ammonium salts, Blood compatible materials, Ammonium/methyl-tridodecyl, Ammonium/methyl-tridecanoyl, NHLI PB-226 886/0 NTIS Prices: PC$3.25/MFS1.45 73' % * uce 042302 i Toxicology of Plastic Devices Having Contact With Blood Utah Oniv., Salt Lake City. (326 900) Interin rept. for 24 Aug 72-15 Sep 73 ADTHOR: Petersen, aobert v. , Lyman, David J., Roll. David B., Swinard, A* C1901C4 FLD: 6T, 6L, 571*. 95A*, 95C USGHDB7324 Sep 73 117p* CONTRACT: NIH-NHLI-73-2908-B MONITOR: NIH/NHLI-7 2-6 ABSTRACT: The project is primarily concerned with toxicological evaluation of polyvinyl chloride and, more specifically, the commonly used plasticizer, di (2-ethylhexyl) phthalate (DEHP). The project is divided into twelve tasks including an organizational phase. Plastic composition studies, acute toxicity studies, tissue culture studies, subacute toxicity studies, metabolite identification, teratogenic studies, neurologic studies, larger animal .studies, analyses of human blood exposed to plastics during hospital procedures, and possible statistical analysis of human patients following extensive exposure of blood to plastics. Selected findings indicate that: DEHP is poorly absorbed . from i,p. = intraperitoneal administration of massive doses; the 30-day subacute i.v. = intravenous LD50 of DEHP in mouse serum is 355 mg/kg in mice; DEHP accumulates in lungs of dogs for at least 2 weeks during daily i.v. = intravenous administration; an efficient method for analyzing DEHP by gas chromatography utilizing an internal standard has been developed; and some components of renal dialysis and cardiac bypass units are toxic to L929 cells by tissue culture methods, portions of this document are not fully legible. DESCRIPTORS: (*plastics, *Blood), (^Toxicology, Plastics), ( Plasticizers, Toxicology) , Medical supplies, polyvinyl chloride. Addition resins. Elastomers, Thermoplastic resins. Tissue culture, nedical equipment. Mechanical organs. Experimental data, Phthalates, Bioassay, Humans, Laboratory animals IDENTIFIERS: Phthalic acidbis(ethylhexyl-ester), materials, *Blood compatible materials, NHL! Biocoapatible PB-224 558/7 NTIS Prices: PC$4.25/HFS1.45 74' I.JCO 042803 Incineration of Plastics Pound in Municipal Wastes Syracuse Oniv. Research Corp., N.Y. (339 750) Final rept. AUTHOR: Heimburg, R. W., Colella, A. R., Jones, D., Bausch, J. H., Macrina, H, C1725L1 FLD: 13B, 68C*, 68A USGRDS7322 Sep 73 246p* GRANT: EP-00304 MONITOR: 3PA--670/2-73-087 ABSTRACT: The purpose of this project was to determine the combustion efficiency of plastics when burned in several types of laboratory incinerators. These laboratory units were designed to simulate the primary flame zones of municipal incinerators. The parameters of efficiency considered were: Percent of material consumed, the chemical cleanliness* of the gaseous effluent, the rate of production of flyash, and the more obvious environmental effects of the gaseous effluent, flyash, and residue-ash. Several pure resins were burned individually in several laboratory incinerators. Also, several mixtures of plastics and a garbage recipe were burned. Results are presented here from analyses of the effluent along with the effects of each effluent on rats and plants for 1- to 8-hour exposures. DESCRIPTORS: {^Plastics, ^combustion), (*Solid waste disposal. Plastics), (*Incinerators, Plastics), Garbage, Fly ash, Air pollution, combustion products. Polyethylene, Polystyrene, polyvinyl chloride. Acrylonitrile copolymers. Polypropylene, polycarbonate resins. Polyurethane resins. Urea formaldehyde resins, Helamines, Toxicology, Rats, Plants (Botany) IDENTIFIERS: NERC PB-223 651/1 NTIS Prices: PC$5.75/MFS1.45 75 i ir.C 042804 i nil Combustion Products from the Incineration of Plastics Michigan. Univ., Ann Arbor. School of public Health. Final rapt, AUTHOR: Boettner, E. A., Ball. G. L., Weise, B. C1501 A3 FLD: 13B, 7C, 68C*, 68A. 59H 0SGBDR7319 1973 154p CONTRACT: EP-00386 MONITOR: EPA-670/2-73-049 ABSTRACT: Analysis of the combustion products of plastics was undertaken to provide scientists and engineers with information needed to design incinerators in order to maximize their efficiency while minimizing maintainance and pollution, to identify products of incomplete combustion potentially recoverable for their fuel or crude chemical value; and to identify products of incomplete combustion which would be acutely toxic in an accidental fire. Plastics studied were polyvinyl chloride, polysulfone, polyurethanes, polyimide. Lopac. Barex. phenol formaldehyde, urea formaldehyde, polyethylene, polypropylene, polystyrene, polycarbonate, polyphenylene oxide, polyester, synthetic fabrics (Dacron, Orion, nylon), and natural products (wood and wool). (Modified author abstract) DESCRIPTORS: (*Plastics, *Combustion products), (*Air pollution. Combustion products), (*Incinerators, Air pollution), (*Solid waste disposal, plastics), Decomposition reactions. Incinerators, Chemical analysis. Gas chromatography. Infrared spectroscopy. Mass spectrometers. Data, Polyvinyl chloride, Thermogravimetric analysis, polyurethane resins, Polyimide resins, area formaldehyde resins. Polyethylene, Polypropylene, Polystyrene, polycarbonate resins. Polyester resins IDENTIFIERS: NERC PB-222 001/0 NTI5 Prices: PC58.00/HFS1.45 76 ucc 042805 t Coal Nine Combustion Products, Identification and Analysis Ultrasystems, Inc., Irvine, Calif. (407 617) Final rapt. 8 Jul 71-7 jul 72 AUTHOR: Paciorek, K. L., Kratzer, C0345E2 FLD: 111, 7C, 81, 710, Jul 72 165p* CONTRACT: H0122009 HONITOR: BuHines-OFR-1-73 R. H., Kaufman, 71H, 57H, 641 J. USGSDH7305 ABSTRACT: Little data is available on oxidative degrative behavior of materials used in coal mines under truly dynamic conditions approximating the mine environment. However, because of the possible danger involved with the formation of toxic gases, the authors studied the decomposition of various materials. Tests were performed on: Polyvinyl chloride-containing materials; Neoprene compositions; Rigid foams (urethanes, isocyanates); Hiscellaneous materials (including jute, fiber glass and polyethylene) using a stagnation burner arrangement. It was found that the chlorine-containing materials evolved hydrogen chloride very readily, its rate of evolution being strongly temperature dependent. The fluorocarbon propellant and C02 were the main products found on decomposition of the foams, whereas among other products jute compositions liberated methyl chloride* The analyses were performed using mass spectrometry and infrared spectroscopy. A review of the combustion products of various polymers is also included. DESCRIPTORS: (combustion products, Polymers), (Coal mines, Fire safety), (Polyvinyl chloride. Combustion products), (*Chloroprene resins, combustion products), (*Cellular plastics. Combustion products ), (*Jute, Combustion products), (Polyurethane,/Combustion products). Glass fibers. Polyethylene, Smoke, Gas analysis. Hazardous materials. Infrared spectroscopy, Hass spectroscopy. Decomposition, Reviews, Cellulose, polyamide resins. Polyester resins. Epoxy resins. Toxicology, Corrosive gases IDENTIFIERS: Hine safety PB-214 124/0 NTIS Prices: PC$6.00/HFS0.95 77 fjnr; 042806 Mi chemical and phys'.cal Properties and Thermal Decomposition Products of Certain Natural F.'oducts and Synthetic Haterials Environmental Health Lab Kelly AFB Tex (300925) Technical rept. AUTHOR: Helvin, Halter w* Jr C0072I2 FLD: 111, 11E, 1 3L, Hay 72 170p* HEPT NO: EHL(K)-7 2-14 PROJECT: EHL-70-7 HONITOR: 18 710, 71H, 711, 83C USGHDR7302 ABSTRACT: A limited review of the literature including the early history and currant data on deaths, injuries and costs due to the combustion and pyrolysis of resins, plastics and natural materials is provided. There is a limited discussion of the chemistry and physical properties of plastics. Applications of these materials in wearing apparel, construction trades, the aircraft industry, and others are discussed. Experimental data on the pyrolysis products of five synthetic and natural fiber carpets are presented. An extensive collection of tables from a number of sources give da-ta on the trade name, type of plastic and manufacturer, physical and chemical properties, decomposition products, and other information. (Author) DESCRIPTORS: (plastics, *Combustion), (Textiles, Combustion), ( Floor coverings. Combustion) , Reviews, Burning rate. Toxicity, clothing. Nylon, Corrosive gases. Fire resistant materials. Pyrolysis, Thermal properties, (Joolen textiles, Polyvinyl chloride. Plasticizers, Carbon monoxide IDENTIFIERS: Fire safety, Carpets, Flammability testing. Smoke, Hydrogen chloride. Hydrogen cyanide AD-751 899 NTIS Prices: PCS3.0Q/HFS0.95 78 I mf; 042807 Materials Based on Polyvinylchloride for Packaging Food Products (Materialy na Osnove Polivinilkhlorida dlya Upakovki Pishcherykh Produktuv)' Army Foreign Science and Technology Center Charlottesville Va 038300) AUTHOR: Chantseva, A. 3., Chernovskaya, H. Ovchinnikov, Tu. V, A2752E3 FID: 111, 13D, 52D, 710 USGRDB7119 14 Jul 71 lOp REPT NO: FSTC-HT-23-886-71 Trans, from Plasticheskie Sassy (USSR) n6 1970. ( ABSTRACT: The physical, mechanical and toxic properties of various types of polyvinyl chloride films suitable for use as food wrapping materials are presented. (Author) DESCRIPTORS: (*Polyvinyl chloride, ^Packing materials), (*Food, Packing materials). Films, Mechanical properties. Toxicity, Additives, Thermal stability, viscosity. Tensile properties, 0SSE IDENTIFIERS: *Food packaging, *Polymeric films. Translations AD-728 150 NTIS Prices: PCS3.00 MFSG.95 7 -I A * l1 79 ucc 042808 m ON THE QUESTION OF IMPROVING SOME POLYVINYL CHLORIDE POLYMERS AND A METHOD OF IMPROVING THEIR TOXICITY Air Force Systems Command, Hright- Patterson AFB, Ohio, Technology Div. AUTHOR: Gorban, G. M. 6011 FI FLD: 11G STAR0709 Apr 68 13p REPT NO: AD-680924, FTD-HT-23-1464-67 Tran- Transl. Into English From Kosmich, Biol. Med. (USSR), 2, 1967 P 47-51 Foreign v. 1, No. DESCRIPTORS: ^Electrical properties, *Plastic tapes, ^Polyvinyl chloride, *Ureas, Degassing, Electrical insalation. Nitrogen compounds N69-20342 CFSTI Prices: PCS3.00 HFS0.95 ABSTRACT: A method is developed for improving the polyvinyl chloride tapes for the purpose of decreasing their gas emanation. The overall gas emission of organic substances from the improved specimens of polyvinyl chloride tapes as a result of the treatment with 50% urea solution is reduced by a factor of 2-1 /2. The improved polyvinyl chloride tapes give off volatile chemical substances in small concentrations, which with long duration of their action on the organism cause only a weak biilogical effect. Asa result of the treatment with a solution of urea there is an improvement in the electrical insulation properties of the polyvinyl chloride tapes serving the purpose for which the materials are intended without change in their strength characteristics. 80 B ucc 042809 THE EFFECTS OF STORAGE CONDITIONS OF PLASTIC BLOOD CONTAINERS OS THE ANTICOAGULANT (ACD) AND THE PRESERVATION OF WHOLE BLOOD AND ITS DERIVATIVES Texas Univ,, Austin. Drag Plastic Research and Toxicology Lab. Terminal rept. AUTHOR: Guess, Wallace L. 584212 FLD: 6L, 6T, 13D 1968 4 1 p* CONTRACT: PH-43-68-97 USGHDR6909 ABSTRACT: On the basis of this study, it was concluded that there is clear evidence of a toxicity potential fro* some PVC blood bags currently available. There is insufficient evidence at the present time to evaluate the effects of storage conditions beyond a one year period, but the study indicated no drastic alterations due to the one year storage period at temperatures up to 50 degrees C. (Author) DESCRIPTORS: (*Blood, storage), (*Bags (Containers) , Blood), ( Polyvinyl chloride. Toxicity), Plastics, Bags (Containers), Anticoagulants, Preservation, Nice, Rabbits, Chromatographic analysis. Temperature, Pathology PB-182 732 CFSTI Prices: PCS6.00 HFS0.95 ucc 042810 ON THE QUESTION OF IMPROVING SOME POLYVINYL CHLORIDE POLYMERS AND A METHOD OF IMPROVING THEIR TOXICITY Foreign Technology Div wright-Patterson AFB Ohio AUTHOR: Gorban, G. M., Yablochkin, V. D. 5603E1 FLD: 111, 22A USGRDR6906 15 Apr 68 12p REPT NO: FTD-HT-23-1464-67 Unedited rough draft trans. of Kosmicheskaya (USSF.) v 1 n2 p47-51 1967, by E. Harter, (141600) Biologiya i Meditsina ABSTRACT: A method is developed for 'improving* the polyvinyl chloride tapes for the purpose of decreasing their gas emanation. The overall gas emission of organic substances from the 'improved* specimens of polyvinyl chloride tapes as a result of the treatment vith 501 urea solution is reduced by a factor of 2 1/2. The 'improved' polyvinyl chloride tapes give off volatile chemical substances in small concentrations, which with long duration of their action on the organism cause only a weak biological effect. As a result of the treatment vith a solution of urea there is an improvement in the electrical insulation properties of the polyvinyl chloride tapes serving the purpose for which the materials are intended without change in their strength characteristics. (Author) DESCRIPTORS: ("Polyvinyl chloride. Processing), Tapes, Gases, Urea, Spacecraft cabins. Carbon dioxide. Aldehydes, Carbon monoxide. Hydrocarbons, Toxicity, Degasification, USSR IDENTIFIERS: Translations AD-680 924 CFSTI Prices: PCS3.00 HFS0.95 82 ucc 042811