Document Dv4LrDwXvR2Zvymj9RNVLpZvQ

i data search on vca for craig elgut Order ntmber 901119-133245-WIZ -001-001 page 74 set 3 with 363 of 363 items DESCRIPTORS REVIEW YEAR UNIFORM IN THE 3 C0N1UNITIES AND APPEARED MOST PROMINENT IN PAINESVILLE. ******* VCM)PVC(BIRTH DEFECTS)HUMAN)EFFECTS(EPIDEMIOLOGY) 1992 Item 229 ACCESSION NUTOER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS REVIEW YEAR 1747 GEN REPORT NIOSH STUDIES WHERE INDUSTRY AND/OR OCCUPATIONAL GROUPS ARE INVESTIGATED NONE,NONE NATIONAL INSTITUTE OF OCCUPATIONAL SAFETY AND HEALTH 1984 THESE ARE ONE PAGE SUMMARIES OF EPIDEMIOLOGY STUOIES. THEY HAVE BEEN USEO BY RALPH NADER TO SHOW CONGRESS EXAMPLES OF INSTANCES WHERE INDUSTRY HAS CONDUCTED RESEARCH BUT HAS NOT NOTIFIED THE WORKERS, VINYL CHLORIDE MONOMER)EPIDEMIOLOGY(HUMANS)EFFECTS(NATIONAL INSTITUTE OF OCCUPATIONAL SAFETY AND HEALTH) 1990 Item 230 ACCESSION NUTOER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** HELD TERMS REVIEH YEAR 1719 GEN PAPER WORKING CONDITIONS AND MEASURES FOR THEIR SANITATION IN THE PRODUCTION AND UTILIZATION OF VINYL CHLORIDE PLASTICS TRIBUKH SL,NONE)TIKHOMIROVA NP,NONE(LEVIN SV,NONE) KOZLOV,NONE) ARG SANIT,VOL 10 PP.38-45} 1949 THIS DOCUMENT IS OFTEN QUOTED BY LAWYERS AS EARLY EVIDENCE OF VCM CAUSING LIVER DAMAGE. HOHEVER, OTHER THINGS SUCH AS PCB'S COULD ACCOUNT FOR ILLNESS OBSERVED. VINYL CHLORIDE MONOMER(CANCER(HUMANS)EFFECTS)LIVER) ACADEMY OF MEOICAL SCIENCES (USSR)) 1998 Item 231 ACCESSION NUTOER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS 1716 GEN PUBLICATION OCCUPATIONAL HAZARDS OF VINYL CHLORIDE AND STYRENE NICHOLSON MJiCITY UNXV OF NEH YORK)HEFMEBERGER PKtSAME) SEIDMAN HSAME)TARR D.SATO) NONE,VOL 141 PP.65-78 155-176 263-278) 1964 ARTICLES PUBLISHED DISCUSS "TRENDS IN CANCER MORTALITY AMONG WORKERS IN THE SYNTHETIC POLYMERS INOUSTRY (PP.65-78) )"OCCUPATIONAL HAZARDS IN THE VC-PVC INDUSTRY lPP.155-176(OCCUPATIONAL HAZARDS IN PRODUCTION OF PROCESSING OF STYRENE POLYMERS--EPIDEMIOLOGIC FINDINGS (PP.263-278)." VINYL CHLORIDE MONOMER(STYRENE(CANCER(HUMANS(EFFECTS(EPIDEMIOLOGY) PROGRESS IN CLINICAL AND BIOLOGICAL RESEARCH) 20867075 BFG51994 dais search on vca for craig elgut Order reenbar 901119-I33246-HIZ -001-001 page 75 eat 3 with 363 of 363 itaas COMMENTS REVIEH YEAR tU<aS) QUESTIONS THE CLAIM THAT VCM CUASES LONG CANCER. 1990 Itea 232 ACCESSION NUFBER 1711 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT GENETIC SUSCEPTIBILITY TO SCLERODERMA-LIKE SYNDROME INDUCED BY VINYL CHLORIDE AUTHOR/AFFI LIATION BLACK CMN0NElHALKER AE,N0NE)CATDGGIO LJ,NONEtHELSH KX,N0NE> BERNSTEIN RM>NONE)MCGREGOR AR,) JONES JKLNQNE) ORIGIN NONE > PPS3-SS> DATE 1903 ABSTRACT VINYL CHL0RI0E IVC) MONOMER CAN INDUCE A SCLERODERMA-LIKE SYNDROME IN A PROPORTION OF WORKERS EXPOSED TO IT OURING PRODUCTION OF POLYVINYL CHLORIDE. AS PART OF A 5-YEAR FOLLOW-UP STUDY HLAA A, B AND DR ANTIGENS AND ANTI-CENTROMERE AND ANTI-SCLERODERMA-70 ANTIBODIES HERE DETERMINED IN 44 SUCH WORKERS. 21 OF THESE HAD SEVERE AND 23 MILD FORKS OF VINYL-CHLORIDE DISEASE. 50 PATIENTS WITH 'CLASSICAL'* SCLERODERMA AND 14B HEALTHY HOSPITAL WORKERS ACTED AS CONTROLS. 11 OF THE 21 PATIENTS CLASSIFIED AS HAVING SEVERE VC DISEASE HERE DR3 POSITIVE,AND 8 OF THESE HAD BOTH B8 AND DR3 ANTIGENS. NONE OF THE 23 PATIENTS KITH HILO OISEASE CARRIED EITHER ANTIGEN. THE HLA-ANTIGEN FREQUENCIES IN VC DISEASE MIRRORED THOSE FOUNO IN SCLERODERMA (RAISED 0R5 FREQUENCY AND INCREASED LINKAGE DISEQUILIBRIUM BETWEEN BB AND DR3). THERE WERE,HOWEVER,SIGNIFICANT DIFFERENCES IN THE FREQUENCY OF AUTOANTIBODIES IN THE TWO CONDITIONS. DESCRIPTORS hhimm SCLERODERMA)VINYL CHLORIDE MONOMER) HUMANS) EFFECTS) HELD TERHS THE LANCET)GLfY `S HOSPITAL! LONDON))HAMiERSMITH HOSPITAL! LONDON)) REVIEH YEAR 1990 Item 233 ACCESSION NUT-BER 1703 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT HEPATIC ANGIOSARCOMA FROM VINYL CHLORIDE. REPORT OF A NEW ITALIAN CASE AUTHOR/AFFILIATION CHIAPPINO GNQNE)BERTAZZI PAN0NE)BARONI M,NONE)MASINI TN0NE) ORIGIN NONE,VOL 6 PP.555-563) DATE 19B2 ABSTRACT THE FOURTH CASE OF ANGIOSARCOMA OF THE LIVER AMONG WORKERS EXPOSED TO VINYL CHLORIDE IN ITALY IS REPORTED. THE CASE NAS A 43 YEARS OLD MAN WHO WORKED FROM 1959 TO 1980 IN A VCM/PVC PRODUCTION PLANT, MOSTLY IN THE POLYMERIZATION AREA. HE OIED IN MARCH 1981, FOUR MONTHS AFTER DIAGNOSIS,FOR A MASSIVE HAEMOPERITONEUM. POST MORTEM EXAMINATION HAS PERFORMED. ACCORDING TO FOUR INDEPENDENT PATHOLOGISTS THE HISTOLOGIC APPEARANCE HAS TYPICAL OF A HIGHLY DEVIATING ANGIOSARCOMA. THE TUMOR DEVELOPED AFTER A SCLEROTIC LIVER LESIONS MAS ALREADY PRESENT. THE ANGIOSARCOMA HAS PROBABLY POLYCENTRIC, HAD A HIGH DEGREE OF MALIGNANCY AND A RAPID LOCAL EVOLUTION WHILE,IN CONTRAST, NO HETASTASES WERE DETECTED. DESCRIPTORS *** ANGIOSARCOMA)VINYL CHLORIDE MONOMERHUMANS)EFFECTS) HELD TERMS MED LAVORO) REVIEW YEAR 1990 Itea 234 2086707S BFG51995 data caarch on vcm for craig alspjt Ordar nuiter 901119-133245-MIZ -001-001 paga 76 sat 3 with 363 of 363 itata* ACCESSION NUTCER 1701 FILE LOCATION DOCUMENT TYPE GEN PUBLICATION TITLE OR SUBJECT ORUG-INOUCED VASCULAR LESIONS OF THE LIVER AUTHOR/AFFILIATION ZAFRANI ES,NONE}PINAUDEAU Y,N0NE)DHUMEAUX DyNONE} ORIGIN NONE>VOL 143 PP.495-502} DATE ABSTRACT 1963v MARCH THE VASCULAR LESIONS OF THE LIVER DESCRIBED IN ASSOCIATION HITH DRUG AND TOXIC SUBSTANCE EXPOSURE ARE REV1ENED HITH SPECIAL REFERENCE TO THE ABNORMALITIES OF THE FOLLOWING:fl) THE HEPATIC VENOUS EFFERENT SYSTEM (IE,LARGE ANO SMALL HEPATIC VEIN OBSTRUCTION I}(2) THE SINUSOIDS (IE,SINUSOIDAL DILATATION, PELXOSIS.PERISINUSOIDAl FIBROSIS)} (3) THE PORTAL VEIN ANO ITS BRANCHES} NO (4) THE HEPAITC ARTERIAL TREE. DRUG-INDUCED VASCULAR TUMORS OF THE LIVER AND VASCULAR CHANGES OBSERVED HITHIN NONVASCULAR TUMORS OF THE LIVER ARE ALSO ENVISAGED. FINALLY, THE PATHOPHYSIOLOCIG MECHANISMS OF ALL THESE LESIONS ARE CONSIDERED. THE AWARENESS OF THIS TYPE OF HEPATOTOXICITY AND THE KNOWLEDGE OF ITS EPIDEMIOLOGY SEEM TO BE ESSENTIAL FOR DOTH ITS EARLY DETECTION AND PREVENTION. DESCRIPTORS wuxx VINYL CHLORXOE MONOMER)LIVER}EFFECTS}ANGIOSARCOMA} HELO TERMS BUDD-CHIARI SYNDROME>VENQ-OCCLUSIYE DISEASE}PELIOSIS HEPATIS) ARCH INTERN MED} REVIEW YEAR 1990 Iten 235 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELP TERMS REVIEW YEAR 1700 GEN PUBLICATION VINYL CHL0RI0E-IMHJCED HEPATIC LESIONS IN MAN AND RODENTS. A COMPARISON POPPER HyNONE}MALT0NI CNONE}SELIKOFF IJ.CITY UNIV OF NEW YORK} NONE,VOL 1 PP.7-20} 1901 HISTOLOGIC SEQUENCES IN THE LIVER OF RODENTS EXPOSEO BY INHALATION TO GASEOUS VINYL CHLORIDE WERE COMPARED TO THE LESIONS IN MAN EXPOSED TO THE SAME AGENT, MAINLY IN VINYL CHLORIDE POLYMERIZATION PLANTS. AN IDENTICAL SEQUENCE.STARTING WITH CIRCUMSCRIBEO PROLIFERATION OF HEPATOCYTES,SOON FOLLOWED BY PROLIFERATION OF A VARIETY OF SINUSOIDAL CELLS ANO FREQUENTLY ASSOCIATED NITH SINUSOIDAL DILATATION,PROGRESSES TO INTRALOBULAR ANO MORE FREQUENTLY TO TRABECULAR ANGIOSARCOMA. PREDOMINANTLY IN YOUNG ANIMALS ANO RARELY IN MAN, HEPATOCECCULAR CARCINOMA DEVELOPS, BUT NEVER CIRRHOSIS. THE SEQUENCE REPRESENTS A DYNAMIC PROCESS OF COMPETITION BETWEEN PROLIFERATING HEPATOCYTES ANO SINUSOIDAL CELLS, OF HEPATOCYTES HITH FIBROPLASIA,BETWEEN PERISINUSOIDAL FIBROSIS AND SINUSOIDAL DILATATION,ANO OF PROLIFERATION OF VARIOUS SINUSOIDAL CELLS VERSUS ANGIOSARCOMA. THE GREAT SIMILARITY IN THE EVOLUTION IN MAN AM) RODENTS,RARELY ENCOUNTERED IN OTHER EXPERIMENTAL MODELS, SUPPORTS THE PREDICTION OF HUMAN CANCER FROM ANIMAL EXPERIMENTS. THE PRECURSOR NODULES DIFFER FROM THE NODULES CGtflONLY OBSERVED IN HEPATOCARCINOGENESIS BY CO-PROLIFERATION OF SINUSOIDAL CELLS. THE DIFFERENCES IN THE REACTIONS BETWEEN MAN ANO RODENTS BESPEAK A STRONG FIBROBLASTIC REACTIVITY IN MAN. MOST IMPORTANT, THE PRECURSOR LESION OF MIXED HEPATOCELLULAR ANO SINUSOIOAL CELL PROLIFERATION MAY BE OF DIAGNOSTIC VALUE, BEING SUPERIOR TO CONVENTIONAL HEPATIC TESTS IN DETECTION OF SOME INITIAL ENVIRONMENTAL LESIONS. VINYL CHLORIOE MONOMER}LIVER)EFFECTS)HUMANS}RAT}PATHOLOGYI MICE} LIVER PUBLICATION}INSTITUTE OF ONCOLOGY (ITALY)}STRATTON LAB} RODENTS} 1990 20867077 9661 data search on vcm for craig el(pjt Order nu^ar 901119-133245-HIZ -001-001 page 77 set 3 with 363 of 363 item 20867078 05V#1 Item 236 ACCESSION NUMBER 1699 FILE LOCATION GEN DOCUMENT TYPE TITLE OR SUBJECT JOURNAL THE TOXICITY OF VINYL CHLORIDE AS DETERMINED BY REPEATED EXPOSURE OF LABORATORY ANIMALS AUTHOR/AFFXLIATION TORKELSON TR.DOH CHEMICAL COlOYEN F,SAME,ROHE VKSAME, ORIGIN AMERICAN INDUSTRIAL HYGIENE ASSOCIATION,VOL 22 NO.5 PP.354-36M DATE 1961, OCTOBER ABSTRACT GROUPS OF LABORATORY ANIHALS HERE EXPOSED REPEATEOLY FOR UP TO SIX MONTHS TO EITHER 500,200,100 OR 50 PPM VINYL CHLORIDE IN AIR. OETECTADLE CHANGES OCCURRED AT ALL OUT THE LOHEST CONCENTRATION THE RESULTS ARE DISCUSSED AND HANDLING PRECAUTIONS SUGGESTED. DESCRIPTORS mmmmmmh VINYL CHLORIDE MONOMER(EFFECTS,RAT * RABBITJGUXWA PIG,SUBACUTE ( REVIEH YEAR 1990 Item 237 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATXON ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEH YEAR 1696 GEN JOURNAL PROGRESSION OF VINYL CHLORIDE INDUCED HEPATIC FIBROSIS TO ANGIOSARCOMA OF THE LIVER JONES DB,NONE,SMITH PM,NONE, NONE,VOL 39 PP.306-307, 1982 THO VINYL CHLORIDE MONOMER <VCMI HORKERS, HHO DEVELOPED NON- CIRRHOTIC PORTAL FIBROSIS ANO PORTAL HYPERTENSION,DIED FROM ANGIOSARCOMA OF THE LIVER FIVE AND TEN YEARS LATER RESPECTIVELY, DESPITE HITHDRAHAL FROM OCCUPATIONAL EXPOSURE. NE SUGGEST THAT NON-CIRRHOTIC PORTAL FIBROSIS CAUSED BY EXPOSURE TO VCM IS POTENTIALLY PREMALIGNANT AND THAT THOSE HORKERS HHO ALREADY HAVE THE CONDITION SHOULD BE CAREFULLY MONITORED. HUMANS,EFFECTS,VINYL CHLORIDE MONOMER,LIVER,ANGIOSARCOMA, BRITISH J OF INDUSTRIAL MEDICINE,LLANDOUGH HOSPITAL IUK)( 1990 Item 238 ACCESSION NUMBER FILE LOCATION 1691 GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN OATE CARCINOGENICITY AND EPIDEMIOLOGICAL PROFILE ANALYSIS OF VINYL CHLORIDE ANO POLYVINYL CHLORIDE KALMAZ EE,UNIVERSITY OF TEXAS,KALMAZ GO,NONE, NONE>VOL 4 PP.13-27, 1984 ABSTRACT THIS IS A VERY BAD REVIEH OF THE CARCINOGENICITY/EPIDEMIOLOGY DATA ON VCM/PVC. CONSIDERATION HAS GIVEN TO HAVING PATRICIA BUFFLER AND MARCUS KEY 00 A CRITIQUE,BUT THEIR TRIP TO CHINA PUT THIS ON HOLD IN DEFINITELY. DESCRIPTORS * POLYVINYL CHLORZDE,VINYL CHLORIOE MONOMER,CANCER,HUMANS,EFFECTS,EPIOEMXOLOGY, HELD TERMS REVIEH YEAR REGULATORY TOXICOLOGY A PHARMACOLOGY, UNIV OF TEMESSEE, 1990 data aaarch on vcn for craig elpjt Order nunfcer 901119-133245-HIZ >001-001 page 78 set 3 with 363 of 363 itens Item 239 ACCESSION NUMBER 1690 FILE LOCATION GEN DOCUMENT TYPE TITLE OR SUBJECT PAPER VINYL CHLORIDE EXPOSURE AND ANGIOSARCOMA OF THE LIVER-- A REPORT OF TIIE ICI REGISTER OF CASES AUTHOR/AFFILIATION DOLL SIR RICHARD,NONE) ORIGIN NONE,NONE) OATE ABSTRACT 1984 THE AUTHORS PREDICT ANOTHER 150-200 DEATHS FROM VCM RELATED ANGIOSARCOMA. THIS PROJECT IS BEING SUPPORTED BY SPI. DESCRIPTORS muHHtnw VINYL CHLORIDE MONOMER(ANGIOSARCOMA(HUMANS(EFFECTS(EPIDEMIOLOGY( COMMENTS RICH) 85 J DRAFT OF AN ARTICLE TO BE PUBLISHED REVIEW YEAR 1987 Item 240 ACCESSION NUTOER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS * REVIEW YEAR 1689 GEN PUBLICATION VINYL CHLORIDE: A CANCER CASE STUOY PURCHASE IFH,NONE (STAFFORD J,NON (PADDLE Gf1,NONE) NONE,NONE) 1984 VINYL CHLORIDE MONOMER (CANCER (ANGIOSARCOMA) HUMANS (EFFECTS)RXSK ASSESSMENT (EPIDEMIOLOGY ( 1987 Itea 261 ACCESSION NUTOER 1686 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT INCIDENCE OF CANCER AMONG VINYL CHLORIDE AND POLYVINYL CHLORIDE WORKERS AUTHOR/AFFILIATION HELDAAS SSNONE(LANGARD SL,NONE(ANDERSEN A,NONE) ORIGIN NONE,VOL 41 PP.25-30) DATE 1984 ABSTRACT THE RESULTS OF A FOLLOW UP STUDY OF THE INCIDENCE OF CANCER AND THE MORTALITY IN A COHORT OF 454 MALE WORKERS PRODUCING VINYL CHLORIDE AND POLYVINYL CHLORIDE ARE PRESENTED. THE STUDY POPULATION WAS REESTRICTED TO EMPLOYEES WITH MORE THAN ONE YEAR'S WORK EXPERIENCE IN THE STUDY PLANT BETWEEN 1950 AND 1969 ANO THE COHORT WAS FOLLOHED UP FROM 1953 TO THE END OF 1979. TWENTY THREE NEW CASES OF CANCER WERE OBSERVED COMPARED WITH 20-2 EXPECTED(ONE CASE OF LIVER ANGIOSARCOMA WAS FOUNO. FIVE CASES OF LUNG CANCER HERE FOUND (2.8 EXPECTED) AND FOUR CASES OF MALIGNANT MELANOMA OF THE SKIN WERE OBSERVED (0-8 EXPECTED). THE POSSIBILITY OF A CAUSAL RELATIONSHIP BETWEEN EXPOSURE TO VINYL CHLORIDE AND THE DEVELOPMENT OF MALIGNANT MELANOMAS IS DISCUSSED. DESCRIPTORS (immhw VINYL CHLORIDE MONOMER (POLYVINYL CHLORIDE (HUMANS (EFFECTS)ERIDEMIOLOGY) CANCER) HELD TERMS BRITISH J OF INDUSTRIAL MEDICINE) MELANOMAS REVIEW YEAR 1990 20867079 BFG51998 data search on vcm for craig el^it Order rxW>er 901119-133Z45-HIZ -001-001 page 79 set 3 with 363 of 363 item* 20867080 Item 262 ACCESSION WJTOER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS HELD TERMS REVIEH YEAR 1687 GEN JOURNAL VINYL CHLORIOEt THE EVIDENCE FOR HUMAN CARCINOGENICITY IN DIFFERENT TARGET ORGANS SALMON AG.NONE} NONE,VOL 42NO.2PP.73-74( 1985, FEBRUARY VINYL CHLORIDE MONOMER(POLYVINYL CHLORIDE|ETHYLENE DICHLORIDE}CANCER(EFFECTS}HUMAMS|EPIQEHI0L06Y} BRITISH J OF INDUSTRIAL MEDICINE I 1995 Itee 243 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ****** HELD TERMS KHIC INDEX NUTfiER REVIEH YEAR 1645 GEN TECHNICAL REPORT VCM FROM PVC DURING THERMAL DECOMPOSITION NONE,NONE* UNION CARBIDE 1975 VCM| PVC} F RAGHENTOGRAPHY 00713REPO 1990 It* 244 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEH YEAR 1374 GEN EPA REPORT ASSOCIATION BETWEEN BIRTH DEFECTS AND EXPOSURE TO AMBIENT VINYL CHLORIDE THERIAULT GP.NONEtZTURRA H,NONE(GINGRAS S,NON} EPA,REPORT NO. EPA 600/1-01-057* 1961, AUGUST SHAHINIGAN HAD AN EXCESS OF BIRTH DEFECTS WHICH FLUCTUATED SEASONALLY IN A NAY THAT COULD CORRESPOND TO CHANGES IN VCM CONCENTRATION IN THE ENVIRONMENT. MOTHERS MHO GAVE BIRTH TO MALFORMED CHILDREN HERE YOUNGER ON AVERAGE IN SHAHINIGAN THAN IN THE COMPARISON COtttJNITIES. HOMEVER, THERE HAS NO EXCESS OF STILLBIRTHS IN SHAHINIGAN, THE EXCESS OF BIRTH DEFECTS INVOLVED MOST SYSTEMS, AND VARIATION IN BIRTH-DEFECT RATES AMONG SCHOOL DISTRICTS COULD NOT BE ACCOUNTED FOR BY ESTIMATES OF VCM IN THE ATMOSPHERE. THE OCCUPATIONAL AND RESIDENTIAL HISTORIES OF PARENTS MHO GAVE BIRTH TO MALFORMED INFANTS MERE COMPAREO HITH THOSE OF PARENTS OF NORMAL INFANTS. THE THO GROUPS OID NOT DIFFER IN OCCUPATIONAL EXPOSURE OR CLOSENESS OF RESIDENCE TO THE VINYL CHLORIDE POLYMERIZATION PLANT. VCM(BIRTH OEFECTSHUMAN*EP1DEHIOLOGY(EFFECTS* LAVAL UN1V( 1991 ,p G 5 l9 9 9 CH data search on van for craig tlgit Order nurfMr 901119-133245-NIZ -001-001 page 60 set 3 with 363 of 363 item* Item 245 ACCESSION NUMBER 1370 FILE LOCATION GEN DOCUMENT TYPE TITLE OR SUBJECT PUBLICATION PRENATAL SUSCEPTIBILITY TO CARCINOGENESIS BY XENOBIOTIC SUBSTANCES INCLUDING VINYL CHLORIDE AUTII0R/AFFILIATI0N RICE JM,NCI ORIGIN ENVIRONMENTAL HEALTH PERSPECTIVESVOL 41 PP.179-166) 0ATE ABSTRACT 1981, OCTOBER THE CARCINOGENICITY OF VINYL CHLORIDE FOR EXPERIMENTAL ANIMALS WHEN ADMINISTERED TRANSPLACEWTALLY IS REVIEWED IN COMPARISON WITH KNOT** TRANSPLACENTAL CARCINOGENS, INCLUDING THOSE THAT, LIKE VINYL CHLORIDE, ARE DEPENDENT ON ENZYME-MEDIATED METABOLIC CONVERSION TO A REACTIVE INTERMEDIATE IN MATERNAL OR FETAL TISSUES. VINYL CHLORIDE IS CONVERTED 6Y MIXED-FUNCTION OXIDASES TO THE REEACTZVE METABOLITE CHLOROQXIRANE,THE CARCINOGENICITY OF WHICH IS ALSO REVIEWED. VINYL CHLORIDE IS UNEQUIVOCALLY A TRANSPLACENTAL CARCINOGEN FOR THE RAT. NO EVIDENCE EXISTS, H9CVER, TO SUPPORT THE HYPOTHESIS THAT EXPOSURE OF MALE RATS TO VINYL CHLORIDE OR ANY OTHER CARCINOGEN CONFERS AN INCREASED RISK OF TUMOR DEVELOPMENT ON THEIR PROGENY. MANY STRUCTURAL ANALOGS OF VINYL CHLORIDE, I.E., SUBSTITUTED ETHYLENES, ARE ALSO CARCINOGENIC FOR ADULT ANIMALS, AND CAN WITH CONFIDENCE LIKEWISE BE PREDICTED TO BE EFFECTIVE TRANSPLACENTAL CARCINOGENS. ALSO REFER TO AN*3664 (PAPER/KHIC 04569). DESCRIPTORS HKMUKini TRANSPLACENTAL CARCINOGEN)VCM)FETAL TOXICITY)RAT) CARCINOGENICITY) REVIEW YEAR 1991 Item 246 ACCESSION NUTOER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT Al/THOR/AFFILIATION ORIGIN DATE DESCRIPTORS mkmmkkm REVIEW YEAR 1367 GEN PUBLICATION SCIENTIFIC AND TECHNICAL ASSESSMENT REPORT ON VINYL CHLORIDE AND POLYVINYL CHLORIDE NONE,NONE) EPA ,600/6-75-004) 1975, JUNE PVC)VCH)HUMAN)EFFECTS)ANALYSIS)RISK ASSESSMENTEMISSIONS) 1990 Item 247 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT Al/THOR/AFFILIATION ORIGIN DATE ABSTRACT 1366 GEN PUBLICATION INFLUENCE OF EXPOSURE MODE ON VINYL CHLORIDE ACTION JEDRYCHOHSKI RA,N0NE)S0KAL JANONE)CHHIELNICKA J,N0NE> ARCH TOXICOL,VOL 55 PP.195-196) 1984 RATS HERE SUBJECTED TO 4 HOURS CONTINUOUS OR INTERMITTENT EXPOSURE TO VINYL CHLORIDE (VC) AT DIFFERENT TIME-WEIGHTED AVERAGE CONCENTRATIONS (15,50,150,500 AND 15,000 MG/H3). AT AVERAGE CONCENTRATIONS OF 50 MG/M3 AND 150 MG/M3, THE URINARY EXCRETION OF TDGA UNDER CONTINUOUS EXPOSURE DID NOT DIFFER FROM THAT UNOER INTERMITTENT EXPOSURE,WHEREAS AT VC CONCENTRATIONS OF 500 MG/M3 AND 15,000 MG/M3 IT WAS HIGHER FOLLOWING CONTINUOUS EXPOSURE. 20867081 B FG 52000 data search on vcm for creig elj^jt Order nunfcer 901119-133245-MIZ -001-001 page fll set 3 with 363 of 363 items 20867082 DESCRIPTORS **** VCM(RATS(INHALATION>MCTABOLISM*EFFECTS> HELD TERMS MEDICAL ACADEMY (POLAND)* REVIEH YEAR 1991 BFG5200l Item 248 ACCESSION NUMBER 1365 FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT GEN PUBLICATION EXPERIMENTAL CONTRIBUTIONS IN IDENTIFYING BRAIN POTENTIAL CARCINOGENS IN THE PETROCHEMICAL INDUSTRY AUTHOR/AFFILIATION MALTONI C,NONE(CILIBERTI A,NONEjCARRETTI D,N0NE* ORIGIN ANNALS OF THE NEH YORK ACADEMY OF SCIENCES,PP.216-299* DATE 1982 DESCRIPTORS ihhhhhw CARCINOGENICITY (BRAIN(TUMORS(EFFECTS*VCH(ACRYLONITRILE(BIS-CHLORQMETHYL ETHERIHYDRAZINEiTRIAZINE* HELD TERMS AROMATIC HYDROCARBONS (NITROSOUREAS(INSTITUTE OF ONCOLOGY (ITALY)* REVIEW YEAR 1991 Item 269 ACCESSION NUF6ER 1366 FILE LOCATION GEN DOCUMENT TYPE REPORT TITLE OR SUBJECT THE 1955-1959 U.S. MORTALITY TABLES FOR AGE 65 AND OVER AUTHOR/AFFILIATION ARMSTRONG B,NONE(GREWURG DN0NE* ORIGIN NONE DATE 1978, JUNE ABSTRACT MORTALITY TABLES FOR U.S. POPULATION. USED FOR RISK ASSESSMENT OF VCM FOR THE CALIFORNIA AMBIENT AIR STANDARD. DESCRIPTORS * VCM*RISK ASSESSMENT (MORTALITY) HELD TERMS U.S.BUREAU OF VITAL STATISTICS* STATISTICS* REVIEH YEAR 1990 Item 250 ACCESSION NUTOER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 1363 GEN PUBLICATION THE EFFETS OF ORGANIC COMPOUNDS USED IN THE MANUFACTURE OF PLASTICS ON THE RESPONSIVITY OF MURINE AND HUMAN LYMPHOCYTES THURMAN GB,UNIV OF TEXASiSIfWS BG,SAME(GOLDSTEIN AL,SAHE*KILIAN 0J,SAME TOX AM)APPLIED,VOL 64 PP.617-641* 1978 THE EFFECTS OF ACUTE EXPOSURE TO A NUMBER OF INDUSTRIALLY IMPORTANT ORGANIC COMPOUNDS ON THE imUNDLOGICAL RESPONSES OF HUMAN AND MURINE LYMPHOCYTES HERE STUDIED. THE COMPOUNDS HERE BENZENE, 1-4-D10XANE, TOLUENE DIISOCYANATE (TDI),VINYL CHLORIDE ,ETHYLENIMINE, AND EPICHLOROHYDR1N. CONTROL COMPOUNDS KNOHN TO HAVE IMMUNOLOGICAL EFFECTS HERE AZOTHIOPRINE, HYDROCORTISONE ACETATE, AND TRIETHYLENE MELAMINE (TEN). THE UPTAKE OF TR1TIATED THYMIDINE ((SH )TDR) OF LYMPHOCYTES HAS USED TO MEASURE THEIR ABILITY TO RESPONO TO MITOGENIC AGENTS, ALLOGENEIC LYMPHOCYTES, OR THE ANTIGENIC NATURE OF THE COMPOUNDS THEMSELVES. MOST OF THE COMPOUNDS HERE FOUND TO BE CYTOTOXIC TO data search on vcm for craig el^it Order number 901119-133265-WIZ -001-001 page 02 set 3 with 365 of 363 items DESCRIPTORS HELD TERMS REVIEW YEAR LYMPHOCYTES AT HIGH CONCENTRATIONS. DIOXANE AND TOI SHOWED EVIDENCE OF SPECIFIC ACTIONS ON THE IMMUNOLOGICAL SYSTEM. DIOXANE SUPPRESSED T-CELL RESPONSES WHILE AUGMENTING B-CELL RESPONSES. TDI EXHIBITED STIMULATORY EFFECTS AT SEVERAL CONCENTRATIONS TO BOTH HIMAN AND WJRINE LYMPHOCYTES. THESE FINDINGS INDICATE THAT OF THE CHEMICALS STUDIED, BOTH OIOXANE AND TDI HAVE PROPERTIES WHICH MAKE THEM CAPABLE OF AFFECTING LYMPHOCYTES IN WAYS OTHER THAN NONSPECIFIC CYTOXICITY. THESE PROPERTIES MAKE TDI AND OIOXANE ESPECIALLY INTERESTING WHEN MONITORING IMFAMOLOGICAL SYSTEMS OF INDUSTRIAL WORKERS WHO HAVE BEEN ACCIDENTALLY EXPOSED TO THESE COMPOUNDS AT HIGH CONCENTRATIONS OR WHO ARE ROUTINELY EXPOSED TO MINIMAL LEVELS OF THESE COMPOUNDS. BENZENE >TDI |VCM)VDC)1,<-0I0XANE )EPI )IN VITRO)LYMPHOCYTESJEFFECTS) ETHYLENININE>ItNJNOLOGIC EFFECT) CYTOTOXICITY) 1990 Item 251 ACCESSION NUIBER 1362 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT MITOCHONDRIAL CHANGES IN HEPATOCYTES OF RATS CHRONICALLY EXPOSED TO VINYL CHLORIDE AND ETHANOL AUTHOR/AFFILIATION MILLER HL.UNIV OF CINCIFMATI)RADIKE MJ>SAME)ANORINGA ASAME)BINGHAH E, SAME) ORIGIN ENVIROMENTAL RESEARCH,VOL 29 PP.272-279) DATE 1982 ABSTRACT CHRONIC EXPOSURE OF HALE RATS TO 600 PPM VINYL CHLORIDE (VC) OR VC AND SZ ETHANOL IETOH) IN DRIVING HATER INDUCED ULTRASTRUCTURAL CHANGES IN THE HITOCHONORIA OF HEPATOCYTES. AFTER 6 MONTHS OF VC/ETOH TREATMENT, HEPATOCYTE MITOCHONDRIA OFTEN CONTAINED RIGID TUBULAR PARALLEL CRISTAE AND DILATED CRISTAE WITH DENSE INCLUSIONSiETHANOL INGESTION ALONE 010 NOT INDUCE THESE MORPHOLOGICAL CHANGES. IN ANIMALS RECEIVING VC ALONE, LARGE FLOCCULAR DENSITIES IN THE MXTOCHONORIAL MATRZX WERE SEEN OCCASIONALLY AFTER 6 MONTHS OF VC INHALATION. THE NUTSERS AND SEVERITY OF CHANGES IN MITOCHONDRIA INCREASED WITH DURATION OF EXPOSURE AND AGE. THE GREATEST RESPONSES OBSERVED IN MITOCHONDRIA OCCURRED NITH THE COMBINED TREATMENT OF VC/ETOH. DESCRIPTORS mmimn VCM)LIVER)RATS(ALCOHOL)DRIM(ING HATER)EFFECTS)CHRONIC) REVIEW YEAR 1990 Item 252 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ****** REVIEW YEAR 1361 GEN PUBLICATION EFFECTS OF INDUCERS ON THE IN VIVO COVALENT BINDING OF A VINYL CHLORIDE METABOLITE TO LIVER FRACTIONS PESSAYRE D,NONE)HANDSCHEER JC,NONE)DESCATOIRE V,NONE)DOLDER A,NONE) BENHAMOU JP,NONE BIOCHEMICAL PHARMACOLOGY,VOL 28 PP.3667-3668) 1979 VCM)METABOLISH)COVALENT BINDINGlIN VXVO)RATS)EFFECTS) 1990 Item 253 ACCESSION NUTCER FILE LOCATION DOCUMENT TYPE 1360 GEN CORR 20867083 BFG52002 data search on vcm for craig algut Order mmbar 901119-133245-HIZ -001-001 page 03 sat 5 with 363 of 363 items TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR mhhhm PROCEDURES FOR THE DETERMINATION OF VCH IN PACIFIERS O'HARA ttf,BFG} BFG-CHEMICAL ,TO VINYLINSTITUTE } 1985, JANUARY 28 TWO DIFFERENT LABORATORIES l*RE ASKED TO DEVELOP AM) CONDUCT EXTRACTION TESTS TO DETERMINE THE AMOUNT OF VCH THAT MIGRATE FROM PVC PACIFIERS. NINE OF TEN TESTS SHOWED THAT NO VCH I LESS THAN 50 PPT) MIGRATES INTO A SALIVA SIMULANT, WHILE THE TENTH SHOWED 120 PPT. BASED ON SAMPLE WEIGHT AND SALIVA SIMULANT NEIGHT, THE 120 PPT VALUE IN THE SALIVA IS EQUIVALENT TO 0.0033 UG, WHICH IS BELOW THE FDA ACCEPTABLE OAILY INTAKE OF 0.011 UG. VCm PVC (MIGRATION (EXTRACTION l PACIFIERS} 1992 Item 254 ACCESSION NUTOER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ihhhhh HELO TERMS REVIEW YEAR 1359 GEN PUBLICATION RISK ASSESSMENT OF EXPOSURE TO VINYL CHLORIDE STOTT NT,DON CHEMICAL COMATANABE PG,SAME( NONE,VOL 53 PP.593-595} 1961 VCM(RISK ASSESSNENT}HUMAN}EFFECTS(CARCINOGENICITY} PURE A APPL CHEM} 1991 Item 255 ACCESSION NUFBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELO TERMS REVIEW YEAR Item 256 1357 GEN PUBLICATION EPIDEMIOLOGIC CONSIDERATIONS IN THE DESIGN OF TOXICOLOGIC STUDIES: AN APPROACH TO RISK ASSESSMENT IN HUMANS HOODS JS.NIH) NONE,VOL 38 NO.5 PP.1892-1696} 1979, APRIL THIS PAPER DESCRIBES A SIX-STEP PROCEDURE FOR INCLUDING EPIOEMIOLOGIC CONSIDERATIONS IN BOTH THE DESIGN AND ANALYSIS OF LABORATORY TOXICITY STUDIES CONDUCTED TO ESTIMATE RISK OF TOXICITY IN HIMANS DURING LOH-LEVEL EXPOSURE TO CHEMICALS IN THE ENVIRONiENT. RISK ASSESSMENT (EPIDEMIOLOGY }VCN}HUMAN}EFFECTS}CARCINOGENICITY( FEDERATION PROCEEDINGS} 1991 ACCESSION NUMBER FILE LOCATION OOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION 1356 6EN PUBLICATION ONCOGENIC AND NJTAGENIC RISKS IN COttHJNITIES WITH POLYVINYL CHLORIDE PRODUCTION FACILITIES INFANTE PF,NONE( 20867084 BFG52003 data search on vcn for craig elgut Order nuttier 901119-133245-HIZ -001-001 page 84 set 3 with 363 of 363 item* ORIGIN 0ATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 1976 AN EXCESS NUMBER OF BIRTH OEFECTS WAS REPORTED FOR COMMUNITIES WITH PVC PRODUCTION FACILITIES. THIS WORK HAS BEEN CRITIZED AS "EPIDEMIOLOGIC GERRYMANDERING". SEE THE REVIEW (KHIC 03646) BY BRIAN MAC MAHON .HARVARD. ALSO REFER TO ANR220KKHIC 01433) INFANTE'S PAPER. VCMlPVC (BIRTH DEFECTS(HUMAN(EFFECTSEPIDEHI010GY( OHIO OEPT OF HEALTH1 1991 Itan 257 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS whhhh REVIEW YEAR 1346 GEN REPORT CALCULATIONS OF THE AMOUNT OF VCM METABOLIZED AT VARIOUS CONCENTRATIONS HINDERER RK,BFG( BFG 1978 VCM(METABOLISMI 1990 Iten 256 ACCESSION NUTOER 1344 FILE LOCATION SEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT BIOCHEMICAL ALTERATIONS IN LIVERS OF RATS EXPOSED TO VINYL CHLORIDE AUTHOR/AFFILIATION OU JT.UNIV OF LOUISVILLE(SANDOZ JP,SAME(TSENG MT,SAHE(TAMBURRO CH.SAME) ORIGIN J OF TOXICOLOGY AND ENVIRONMENTAL HEALTH*VOL 5 PP.1119-1132( DATE 1979 ABSTRACT SPRAGUE-DANLEY RATS HERE EXPOSED TO VINYL CHLORIDE TO DETERMINE THE EARLIEST SEQUENTIAL BIOCHEMICAL CHANGES OCCURRING NITH LIVER INJURY BEFORE ANGIOSARCOMA DEVELOPMENT.THERE HERE NO CHANGES IN SEVEN CONVENTIONAL CLINICAL BIOCHEMICAL LIVER TESTS OR IN FOUR OTHER MARKERS OF LIVER MITOCHONDRIAL, CYTOSOL, AND MICROSOMAL FUNCITON. NO SIGNIFICANT HISTOLOGICAL CHANGES HERE FOUND ON LIGHT MICROSCOPIC EXAMINATION DURING THIS EXPOSURE PERIOD. HOWEVER, WITH ELECTRON MICROSCOPY* DILATION OF ROUGH ENDOPLASMIC RETICULUM HAS SEEN IN THE ANIMALS EXPOSED FOR MORE THAN 137 HRS. DESCRIPTORS mum< VCM(LIVERRATS(ANGIOSARCOMA( REVIEW YEAR 1990 Item 259 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 1343 GEN PUBLICATION NEOPLASTIC RISK AMONG HORKERS EXPOSED TO VINYL CHLORIDE HAXHEILER RJ,NIOSH(STRINGER W,SAME(WAGONER JK,SAME IJONES JSAME( FALK H*CDC(CARTER C,SAME( AhMALS OF THENEW YORKACADEMY OFSCIENCES*PP.40-46t 1976 IN THE PRESENTSTUDY OF HORKERSEXPOSEO TO VINYL CHLORIDE, AN EXCESSIVE NUTDER OF DEATHS DUE TO CANCER OF THE SAME FOUR SITES HAS FOUND, VIZ THE LIVER,LUNG,AND THE LYMPHATIC AND CENTRAL NERVOUS 20867085 BFG52004 data search on vcn tor craig elgut Order mmfcer 901119-133295-HIZ -001-001 page 65 set 3 with 363 of 363 items DESCRIPTORS REVIEH YEAR SYSTEM. THE EVIDENCE, BOTH EPIDEMIOLOGICALLY AND HISTOPATHOLOGICALLY> POINTS TO VINYL CHLORIDE AS THE CAUSAL AGENT IN THE ETIOLOGY OF SUCH EXCESSIVE CANCER RISK. THE OBSERVATION OF THE CARCINOGENICITY OF VINYL CHLORIDE. FIRST IN ANIMALS AND SUBSEQUENTLY IN MAN, STRONGLY SUPPORTS THE NEED FOR CONDUCTING ANIMAL BIOASSAY PRIOR TO INTRODUCTION OF CHEMICAL AND OTHER AGENTS INTO THE INDUSTRIAL OR COMMUNITY ENVIRONS.SEE ALSO KHIC04625 (PAPER). * VCM)HUMAN)EFFECTSCARCINOGENICITY)EPIDEMIOLOGY} 1991 Item 260 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEN YEAR ihhhhh 1311 GEN REPORT EPIDEMIOLOGICAL STUDY OF VINYL CHLORIDE WORKERS :FINAL REPORT. NONE,NONE I NONE 1976, JANUARY EPIDEMIOLOGY STUDY OF U.S. VCM/PVC WORKERS SHOWS INCREASE IN CARDIOVASCULAR AND RENAL DISEASE. THIS STUDY SUPPORTS THE HYPOTHESIS THAT VCM CAUSES LIVER,LUNG AND DRAIN CANCER. VCM)PVC)HUMANEFFECTS)EPIDEhIOLOGY} EQUITABLE ENVIRONMENTAL HEALTH INC) 1990 Item 261 ACCESSION NUTOER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS HELO TERMS REVIEW YEAR 1310 GEN REPORT EPIDEMIOLOGIC STUDY OF VINYL CHLORIDE WORKERS EMPLOYED BY UNION CARBIDE CORPORATION,SOUTH CHARLESTON PLANT NONE,N0NE > NONE,FOR UNION CARBIDE CORP) 1976, DECEMBER VCM)HUNAN)EFFECTS)EPIOEMIOLOGY > EQUITABLE ENVIRONMENTAL HEALTH INC} 1990 Item 262 ACCESSION NUFBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS * REVIEH YEAR 1309 GEN PUBLICATION RESULTS OF PROSPECTIVE MORTALITY STUDY ON HUMANS EXPOSED TO YC/PVC FRENTZEL-BEYHE VR,N0NE1SCHMITZ TNONE}THIESS AM,NONE} NONE,NONE} 1976, OCTOBER PVC)VCM)HUMAN)EFFECTS)EPIDEMIOLOGY) 1991 20867086 BFG52005 data search on vca for craig el(pjt Order rxafcer 901119-133245-WIZ -001-001 page 86 sat 3 with 363 of 363 item 20867087 BFG52006 I tea 263 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT HELD TERMS REVIEH YEAR Itea 264 ACCESSION NUTOER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS REVIEH YEAR I tea 265 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 1300 GEN PUBLICATION CONTEMPORARY PEST CONTROL PRACTICES AND PROSPECTS - VOL 1: CARCINOGENESIS IN MAN AND LABORATORY ANIMALS NONE,NONE I NONE 1975 STATEMENT MADE WITH REFERENCE TO VCH THAT ANIMALS OVERESTIMATE RISK OF CANCER. RODENTS) NATIONAL ACADEMY OF SClENCESlNASt 1991 1304 GEN PAPER AN EPIDEMIOLOGIC INVESTIGATION OF LUNG CANCER IN A HJLTIXENOBIOTIC OCCUPATIONAL ENV1ROMCNT HAXHEILER RJ,UNIV OF NORTH CAROLINA) UNIV OF NORTH CAROLINA 1978 AN EXCESS LUNG CANCER RISK (39 OBSERVED AND 27 EXPECTED) HAS OBSERVED AMONG A COHORT OF 4806 MALES EMPLOYED AT A SYNTHETIC CHEMICAL PLANT SINCE IT 0PENE0 IN 1942. UPON REVIEH OF THE PATHOLOGIC MATERIAL* THE EXCESS HAS FOUND TO BE LIMITED TO ADENOCARCINOMA AND LARGE CELL UNDIFFERENTIATED LUNG CANCER. MANY OF THE WORKERS HERE EXPOSED TO VINYL CHLORIDE* BUT OTHER EXPOSURES INCLUDING CHLORINATED SOLVENTS* POLYVINYL CHLORIDE <PVC> DUST* ACRYLATES* AND ACRYLONITRILE EXISTED. THUS, DETAILED WORK HISTORIES OF EACH COHORT MEf-CER ALONG MITH EXPOSURE RATINGS OF EACH JOB FOR EACH CALENDAR YEAR SINCE 1942 FOR EACH OF NINETEEN DIFFERENT CHEMICALS (OR CHEMICAL GROUPS) HERE OBTAINED. A SERIALLY ADDITIVE EXPECTED DOSE MODEL HAS CONSTRUCTED WHICH COMPARED THE DOSES OF THE CHEMICALS OBSERVED FOR THE LUNG CANCER CASES TO THE DOSES EXPECTED BASED ON SUBCOHORTS INDIVIDUALLY HATCHED TO THE CASES. PVC DUST APPEARED TO BE THE MOST LIKELY ETIOLOGIC AGENT. OBSERVED AND EXPECTED DOSES HERE THEN ANALYZED BY YEAR BEFORE DEATH TO UNCOVER THE RELEVANT LATENT PERIOD. PVC DUSTVCM)LUNG)CARCINOGENICITY{EPIDEMIOLOGY)HUMAN{EFFECTS* 1991 1293 GEN REPORT THE MEDICAL COFWISSION ON THE PRODUCTION OF PVC. NONE,NONE) NONE,NONE) 1974* DECEMBER HE CONSIDER IT AN ESTABLISHED FACT THAT VINYL CHLORIDE CAN CAUSE CANCER IN HUMANS. NO HUMAN data arch on vein for craig elgut Order nutter 901119-133245-HXZ -001-001 page 67 set 3 with 363 of 363 items 20867088 DESCRIPTORS HELD TERNS REVIEH YEAR ACTIVITY* J06 OR HABIT IS HITH0UT SOME RISK* AND HE SHOULD AVOID SETTING UP RULES OR OPINIONS WHICH MOULD ONLY SERVE TO EXCHANGE ONE KIND OF HAZARD FOR ANOTHER OF POSSIBLY GREATER DIMENSION. VCM)CANCER)HUMANlEFFECTS) NORSK HYDRO (NORWAY) 1990 BFG52007 Item 266 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** HELD TERNS REVIEH YEAR 1292 GEN REPORT PRELIMINARY REPORT ON THE MEDICAL EXAMINATION OF 266 EMPLOYEES AT THE PVC PLANT* NORSK HYDRO A.S* PORSGRUM FABRIKKER HILLESTAD L*NONE) NONE*NONE) 1975* JANUARY 31 CHROMOSOMAL ABERRATIONS SEEN IN VCK/PVC WORKERS. VCM PVC(CHROMOSOMAL ABERRATION ^CARCINOGENICITYlHUMAN)EFFECTS) MUTAGENICITY) NORSK HYORO (NORWAY) 1990 Item 267 ACCESSION NUFBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** REVIEH YEAR 1291 GEN PUBLICATION OCCUPATIONAL ACROOSTEOLYSIS III. A CLINICAL STUDY DODSON VN*NONE)Dir*IAN BD*NQNE)HHITEHOUSE N1*N0NE)NASR AHM*NONE) HAGNUSON HJ*NONE) ARCH ENVIRON HEALTH*VOL 22) 1971* JANUARY ACROOSTEOLYSIS)VCM)HUMAN)EFFECTS) 1990 Item 268 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS **** REVIEH YEAR 1290 GEN PUBLICATION OCCUPATIONAL ACROOSTEOLYSIS II. AN INDUSTRIAL HYGIENE STUDY COOK HA*NONE)GIEVER PM,N0NE)DI)t1AN BD>NONE)MAGNUSQN HJ.NONE) ARCH ENVIRON HEALTH*VOL 22) 1971* JANUARY ACROOSTEOLYSIS)HUMAN)EFFECTS)VCM) 1990 Item 269 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE 1269 GEN PUBLICATION data search on vca for craig elgut Order mmtoer 901119-133245-HIZ -001-001 page 80 set 3 with 363 of 363 items TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS mnumiw REV1EH YEAR OCCUPATIONAL ACROOSTEOLYSIS: I. AN EPIDEMIOLOGICAL STUDY DIM1AN BO>NONE)COOK HA,NONEiNHITEHOUSE MlNONE)KAGNUSCW HJ,N0NEt DITCHECK T,N0NE ARCH ENVIRON HEALTH,VOL 22 1971, JANUARY ACROOSTEOLYSISiVCMlEPIDEMIOLOGY1 HUMAN (EFFECTS 1 1990 Item 270 ACCESSION NUTBER 1287 FILE LOCATION GEN DOCUMENT TYPE PAPER TITLE OR SUBJECT AUTHOR/AFFILIATION VINYL CHLORIDE CONTENT OF SUBCUTANEOUS ADIPOSE TISSUE FROM VINYL CHLORIDE POLYMERIZATION HORKERS KNITTLE JL.CITY UNIV OF NEH YORK)FONTAKARES P,SAME>OAUM S>SAMEtSELIKOFF IJ, SAMEi ORIGIN NONE DATE 1974, DECEMBER ABSTRACT SIGNIFICANT LEVELS OF VINYL CHLORIDE M0N0HER HERE FOUND IN SUBCUTANEOUS FAT DEPOTS OF H0RKERS EXPOSED TO THE GAS DURING THE MANUFACTURE OF POLYVINYL CHLORIDE. THE COMPOUND HAS NOT DETECTED IN A CONTROL GROUP OF UNEXPOSED WORKERS. DESCRIPTORS kmmkmmii VCME FFECTS* HUMANFAT REVIEW YEAR 1990 Item 271 ACCESSION NUTBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS luuuunm REVIEW YEAR 1278 GEN GUIDELINES VINYL CHLORIOE :COOE OF PRACTICE FOR HEALTH PRECAUTIONS NONE,NONEl HEALTH AND SAFETY EXECUTIVE,PP.1-41} 1975, FEBRUARY VCM( 1990 Item 272 ACCESSION NUTBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS *** REVIEW YEAR 1277 GEN BIBLIOGRAPHY HEALTH EFFECTS OF VINYL CHLORIDE MONOMER: AN ATMOTATED LITERATURE COLLECTION WARREN H,OAK RIDGE NATIONAL LABtHUFF JE,SAME| ENVIROM1ENTAL HEALTH PERSPECTIVES,VOL 11 PP.251-252) 1975, JUNE VCM(EFFECTS(HUMAN( 1990 Item 273 ACCESSION NUIBER FILE LOCATION 1242 GEN 20867089 BFG52008 data search on von for craig elgut Order mmfcer 90U19-133Z45-HIZ -001-001 page 89 set 3 with 363 of 363 itees DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS HELD TERMS REVIEW YEAR PUBLICATION ACR0PATHY OF THE EXTREMITIES ASSOCIATED WITH VC POLYMERIZATION--A NEM OCCUPATIONAL DISEASE KOVAC A,NONE(KURAJICA LN0NE}JURIC-RUZIC D,NONE}PARAC B,N0NE| NONE,VOL 91 NO.5 PP.5-17} 1969 VCM}POLYMERIZATION}ACROOSTEOLYSIS ACROPATHYLIJ.VJES1 1990 Itee 274 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS HELO TERMS REVIEH YEAR 1231 GEN GOVERM1ENT CORR BFG'S SUBMISSION OF HISTORICAL DATA AND ANALYTICAL TEST PROCEDURES TO FDA ON RVCM OF PVC RESINS AND COMPOUNDS OSBORNE EB,BFG-CHEMICAL} BFG-CHEHICAL,TO FDA} 1975, AUGUST 13 VCM >PVCJFDA(POTABLE HATER>ANALYSIS> RVCM* 1990 Item 27 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS mmxmtJt REVIEW YEAR 1228 GEN STANDARDS VINYL CHLORIDE AS AN INGREDIENT OF DRUG AND COSMETIC AEROSOL PRODUCTS!FINAL RULE). NONE,NONE FEDERAL REGISTER,VOL 39 NO.166 PP.30830} 1974, AUGUST 26 VCM}FDA (AEROSOL} 1990 Item 276 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATI0N ORIGIN DATE DESCRIPTORS hhiik HELD TERMS REVIEW YEAR 1227 GEN GOVERNMENT CORR VINYL CHLORIDE FROM FOOO PACKAGING (CITIZEN PETITION) KAMPELMAN J,NONE JJOHNSON A,NONE(WOLFE SM,N0NE> NONE,TO FDA HEARING CLERK} 1975, JULY 1 FDA}VCM}PVC} PUBLIC CITIZEN'S HEALTH RESEARCH GROUP} 1990 Item 277 20867090 BFG52009 dai search on voa for craig algut Order wsfcir 901119-133245-WIZ -001-001 page 90 set 3 with 363 of 363 item ACCESSION NUttER FILE LOCATION Docuecr type TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS WWWWW REVIEW YEAR 1226 GEN STANDARDS PRIOR-SANCTIONED POLYVINYL CHLORIDE RESIN 1 TERMINATION OF NOTICE OF PROPOSED RULEMAKING) NONE,NONE) FEDERAL REGISTERVOL 40 NO.171 PP.40529) 1973* SEPTEWER 3 PVC)VCM)FOA) 1990 It 278 ACCESSION NUTSER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS mhhhhhi REVIEW YEAR 1225 GEN PAPER VINYL CHLORIDE POLYMERS IN CONTACT WITH FOOD (NOTICE OF PROPOSED RULE MAKING) NCNENOC) F0A.CFR1Z1 DOCKET NO.75N-0190) 1975 VCW)PVC)FDA) 1990 Itsi 279 ACCESSION MASER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS wwwi KNIC INDEX NLBBER REVIEW YEAR 1196 GEN JOURNAL ANGIOSARCOMA OF THE LIVER IN VINYL CHLORIDE/ POLYVINYL CHLORIDE WORKERS NONE,NONE) J OF OCCUPATIONAL HEOICINE ,VOL 16 NO.12) 1974 ANGIOSARCOMA) LIVER) VCW) PVC) 00I77PISL 1990 Itan 280 ACCESSION MINER 1187 FILE LOCATION GEN DOCUMENT TYPE PAPER TITLE OR SUBJECT CYTOGENETIC STUDIES OF BONE HARROW CELLS FROM RATS EXPOSED TO VINYL CHLORIDE AUTHOR/AFFILIATION JOHNSTON RVDOH CHEMICAL CO)HENSIK OJ SAHE )PIMCERTON Mi*SAME) MfORTON EB.UNIV OF TEXAS) ORIGIN DOM CHEMICAL CO*FOR MCA DATE 1975 ABSTRACT STUDIES BY THE BIOMEDICAL ANO COMPARATIVE TOXICOLOGY RESEARCH LABORATORY OF THE DOM CHEMICAL COMPANY)FREPORT* TEXAS* SHOW THAT THERE HAS NO SIGNIFICANT INCREASE IN THE CHROMOSOMAL ABERRATION RATES OF BONE HARROW CELLS OF RATS EXPOSED TO VARYING DOSES OF VINYL CHLORIDE FOR ONE YEAR AT INDUSTRIAL BIO-TEST LABORATORIES* DECATUR* ILLINOIS. J DESCRIPTORS MUTAGENICITY) VINYL CHLORIDE MONOMER) BONE HARROW) CHROMOSOMAL ABERRATION >IWALATION )RATS) HELD TERMS CYTOGENETIC EFFECTS) CHROMOSOMAL ABNORMALITIES 20867091 BFG52010 data search on vcm for craig algpjt Order nunber 901119-133245-MIZ -001-001 page 91 sat 3 with 363 of 363 items KNIC INDEX NUMBER REVIEW YEAR 00367PAPE 1990 Item 281 ACCESSION NUMBER 1182 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT CARCINOGENICITY BIOASSAYS OF VINYL CHLORIDE:1.RESEARCH PLAN AND EARLY RESULTS AUTHOR/AFFILIATION LEFEM1NE G.NONE) MALTONI C,N0NE> ORIGIN ENV1RCM1ENTAL RESEARCH>VOL 7 PP.387-4D5) DATE 1974 ABSTRACT THESE INVESTIGATIONS ARE CONCERNED WITH DETERMINING THE ONCOGENIC POTENTIALITIES OF VINYL CHLORIDE I VC) IN EXPERIMENTAL ANIMALS. THE EFFECT OF THIS COMPOUND IS BEING STUOIE0 IN RELATION TO VARIOUS EXPERIMENTAL FACTORS, SUCH AS ROUTE OF ADMINISTRATION, DOSE LEVEL,LENGTH OF TREATMENT SPECIES, STRAIN, AND AGE OF THE ANIMALS. PRELIMINARY RESULTS ME PRESENTED. HHEN GIVEN BY INHALATION, VC INDUCES IN RATS, ZYttAL GLAND CARCINOMAS, NEPHROBLASTOMAS, AND ANGIOSARCOMAS OF THE LIVER AND OF OTHER ANATOMICAL SITES) AND IN MICE, PULMONARY ADENOMAS, HAFV1ARY CARCINOMAS AND LIVER ANGIOSARCOMAS. A DIRECT RELATIONSHIP HAS BEEN FOUND BETNEEN DOSE AND LENGTH OF TREATMENT AND NEOPLASTIC RESPONSE. DESCRIPTORS unwim VINYL CHLORIDE) CARCINOGENICITY) INHALATION) MICE) RATS) KMIC INDEX NUMBER 00362PUBL REVIEW YEAR 1990 Item 282 ACCESSION NUtBER 1181 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT VINYL CHLORIOE INDUCED LIVER DISEASE AUTHOR/AFFILIATICN THOMAS LBNCI)POPPER H,NOME)BERK PD,NONE)SELIKOFF I,NONE) FALK H,NOE) ORIGIN NOME,VOL 292 NO.l) DATE 1975, ABSTRACT HISTOLOGIC EXAMINATION OF LIVER TISSUE (EIGHT AUTOPSY AND 18 BIOPSY SPECIMENS) AND FIVE SPLEENS FROM 20 WORKERS NITH VINYL CHLORIDE POLYMERIZATION SHOWED HEPATIC ANGIOSARCOMAS IN 15. IN ADDITION, A PECULIAR PATTERN OF PROGRESSIVE PORTAL-TRACT,INCONSPICUOUS INTRALOBULAR AND CONSPICUOUS CAPSULAR FIBROSIS WAS OBSERVEO IN THE FIVE WORKERS WITHOUT ANGIOSARCOMA, IN ALL THE SEVEN PATIENTS WITH ANGIOSARCOMA FROM WHOM TUMOR-FREE PORTIONS OF THE LIVER HERE AVAILABLE, 1 AND IN TWO TUMOR-FREE BIOPSIES FROM PATIENTS SUBSEQUENTLY FOUND TO HAVE ANGIOSARCOMA. THE FIBROSIS HAS ACCOMPANIED BY SPLENOMEGALY. HYPERTROPHY AND HYPERPLASIA OF BOTH HEPATOCYTES AND HEPATIC AND SPLENIC MESENCHYMAL CELLS HERE ALSO SEEN. THE HISTOLOGIC SIMILARITY TO CHRONIC INORGANIC ARSENICAL POISONING, IN WHICH ANGIOSARCOMAS ALSO OCCUR, AND TO 1010- PATHIC PORTAL HYPERTENSION (BANTI'S SYNDROME) SUGGESTS THAT THE LATTER SYNDROME AT TIMES RESULTS FROM UNKOHN TOXIC, POSSIBLY ENVIRONMENTAL, CHEMICALS. DESCRIPTORS mmmum ANGIOSARCOMA) VCM) HUMAN) EFFECTS) CHRONIC) ARSENIC) HELD TERMS HEPATOTOXICITY) SPLENOMEGALY) NEW ENGLAND J OF MEDICINE) KHIC INDEX NUMBER 00361PUBL REVIEW YEAR 1991 20867092 BFG52011 data search on vcm -for craig elgut Order nuitwr 901U9-133245-MIZ -001-001 page 92 set 3 with 363 of 363 item 20867093 lfG 520 Item 283 ACCESSION NUMBER 1174 FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION GEN TOXICITY STUDY EXPERIMENTS ON THE CHRONIC TOXICITY OF A COPOLYMER OF VINYL AND VINYLIDINE CHLORIDE SEELER AO,HARVARD UNIV)CLINTON H,SAME)BOGGS J,SAME) DRIVER P,SAME> ORIGIN HARVARD UNIV DATE 1947 ABSTRACT RATS FED A OIET CONTAINING SX VINYL AND VINYLIDINE CHLORIOE COPOLYMER FOR TMO YEARS SHOWED NO TOXIC EFFECTS. TMO DOGS WERE FED A DIET CONTAINING 5/ VINYL AND VINYLIDINE CHLORIDE COPOLYTBR FOR TMO YEARS WITHOUT EVIDENCE OF TOXIC EFFECTS. DESCRIPTORS * PVC) VCM) CHRONIC) CARCINOGENICITY) RATS) DOGS) ORAL) HELD TERMS DIET)VINYLIDINE CHLORIDE) KHIC INDEX NUTBER 0D353T0XS REVIEW YEAR 1995 Item 284 ACCESSION NUTBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS * HELD TERMS KHIC INDEX NUMBER REVIEN YEAR 1138 GEN JOURNAL INDUSTRY'S LATEST CANCER SCARE NONE,NONE) NONE 1974, FEBRUARY LIVER) ANGIOSARCOMA) PVC) VINYL CHLORIOE) VINYLIDENE CHLORIDE) BUSINESS WEEK) 00315PUBL 1990 Itew 285 ACCESSION NUTBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS hhiwhii HELD TERMS KHIC INDEX NUTBER REVIEN YEAR 1137 GEN JOURNAL PROPERTIES AND ESSENTIAL INFORMATION FOR SAFE HANDLING AM) USE OF VINYL CHLORIDE NONE,NONE) NONE 1972 VINYL CHLORIDE) TOXICITY OATA) LIVER) MCA) 00314PUBL 1990 Iten 286 ACCESSION NUTBER FILE LOCATION 1121 GEN data search on vcm for craig aljpjt Order nurfar 901119-133245-HIZ -001-001 paga 93 *t 3 with 363 of 363 item* DOCUMENT TYPE TOXICITY STUDY TITLE OR SUBJECT AlfTHQR/AF FILIATION A STUDY OF THE TOXICITY OF GECN 202 RESIN SEELER AO,HARVARD UNIVCLINTQN HSAME*BOGGS J,SAME* DRIVER P,SAME} ORIGIN HARVARO UNIV,FOR BFGl DATE ABSTRACT 1997 DIETARY ADMINISTRATION OF GEON 202 RESIN AT 5X FOR TNO YEARS DID NOT PRODUCE ANY COMPOIMO RELATED EFFECTS IN RATS OR DOGS. DESCRIPTORS ******* VCM}VDC}PVC)EFFECTSDIT>RATS>DOGS}CHRONICl HELD TERMS GEON 202} KWIC INDEX NUMBER OO290TOXS REVIEH YEAR 1992 Item 2S7 ACCESSION NUFCER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ! HELO TERMS KNIC INDEX NUTOER REVIEH YEAR 931 GEN JOURNAL ONCOGENIC RESPONSE OF RAT SKIN LUNGS AND BONES TO VINYL CHLORIDE CAPUTO A>N0NEjBIGOTTI A,SAME)VIOLA PL,SAME* CANCER RESEARCH>VOL 31 PP.16-522} 1971, MAY RATS (AR/IRE HISTAR STRAIN) EXPOSED FOR 12 MONTHS TO VAPORS OF VCHI30,OOOPPM) DEVELOPED TUMORS OF THE SKIN,LUNGS ANO BONES. THE CUTANEOUS TUMORS, WHICH ALWAYS APPEARED IN THE AREA IN WHICH SUBMAXILLARY AND PAROTID GLANDS ARE LOCATED, HAVE BEEN HISTOLOGICALLY RECOGNIZED AS EPIDERMOID CARCINOMAS , PAPILLOMAS, AND MUCOEPIOERMOIO CARCINOMAS. THE MORPHOLOGICAL CHARACTERISTICS OF LUNG TUMORS, WHICH OCCURED IN A LOWER PERCENTAGE, WERE MAINLY OF THE ADENOCARCINOMA TYPE, WITH THE EXCEPTION OF A SINGLE EPIDERMOID TUMOR ORIGINATING FROM THE EPITHEHAL COVERING CELLS. IN A MINOR NUMBER OF RATS, A LARGE PROLIFERATION OF CARTILAGINOUS TISSUE DIAGNOSED AS OSTEOCHONDROMA DEVELOPED IN THE METACARPAL AND METATARSAL REGIONS OF THE FOUR LIMDS. VCHi INHALATION} RATS} CARCINOGENICITY} EFFECTS} CHRONIC} REGINA ELENA INSTITUTE FOR CANCER (ITALY)} 00Q97PUDL 1990 Item 260 ACCESSION NUMBER 689 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT AUTHOR/AFFILIATIGN THE CORRELATION OF CLINICAL AM) ENVIRONMENTAL MEASUREMENTS FOR WORKERS EXPOSED TO VINYL CHLORIDE KRAMER CG,D0H CHEMICAL COtMJTCHLER JE,SAME> ORIGIN AIHA,VOL 33 NO.l PP.19-30} DATE 1972, JANUARY ABSTRACT A METHOD IS DESCRIBED FOR THE STATISTICAL CONSOLIDATION AND CORRELATION OF ENVIRONMENTAL MEASUREMENTS AM) CLINICAL FINDINGS USING AS AN EXAMPLE A GROUP OF HEALTHY MALE WORKERS EXPOSED ROUTINELY TO VINYL CHLORIDE FOR PERIODS UP TO 25 YEARS. RETROSPECTIVE IN NATURE THE STUDY REVEALS SEVERAL STATISICALLY SIGNIFICANT EFFECTS FROM CHRONIC EXPOSURES TO VINYL CHLORIOE ANO TRACES OF VINYLIDENE CHLORIDE. DESCRIPTORS hwhw VINYL CHLORIDE}HORKERS}EXPOSURE> VINYLIDENE CHLORIDE}CHR0NIC} EFFECTS} REVIEH YEAR 1990 Z08670H BFU52013 data saarch on vcm for craig alpjt Order rumfear 901119-133245-HIZ -001-001 page 94 set 3 with 363 of 363 items Item 289 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT ALTTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ****. HELD TERMS KHIC INDEX HUBER REVIEN YEAR 686 GEN PUBLICATION LIFESPAN ORAL TOXICITY STUDY OF VINYL CHL0RI0E IN RATS FERON VJN0NEjHENORIKSEN CEM.NONE>SPEEK AJ.NONEiTIl HP.NONE) SPIT BJ.NONE) NONE,VOL 19 PP.317-333) 1981, JUNE THE PRESENT STUDY SHOWED THAT ORALLY ADMINISTERED VCH IS A CARCINOGEN IN RATS, AND THAT THE "NO-OBSERVED-ADVERSE-EFFECT LEVEL" IN RATS HAS LOWER THAN 1.7 MG/KG BODY HEIGHT/DAY UNDER THE RIGOROUS COtBITIONS OF CONTINUOUS ORAL VCM EXPOSURE RESULTING FROM THE RELEASE OF VCM FROM PVC POWDER PRESENT IN THE GASTRO- INTESTINAL TRACT. ORAL)PVC}VCM t RATS ^CARCINOGEN)DIET FOOD AND COSMETICS TOXICOLOGY 04335 1990 Itan 290 ACCESSION NUMBER 887 FILE LOCATION GEN DOCUMENT TYPE REPORT TITLE OR SUBJECT LIFESPAN ORAL CARCINOGENICITY STUDY OF VINYL CHLORIDE IN RATS (FINAL REPORT) AUTHOR/AFFILIATION TIL HP.NONE)IMHEL HR,NONEiFERON VJ,NONEt ORIGIN NOtC,REPORT NO.V83.265/291099 DATE 1983, SEPTEMBER ABSTRACT IT HAS CONCLUDED THAT UNDER THE CONDITIONS OF THE PRESENT EXPERIMENT: VCH AT A LEVEL OF 1.3 MG/KG BODY HEIGHT/DAY INDUCES NEOPLASTIC AND NON-NEOPLASTIC CHANGES IN THE LIVER OF RATS) VCM AT A LEVEL OF 0.13 MG/KG BODY MEIGHT/DAY MAY LEAD TO MORE FEMALE RATS BEARING FOCI OF CELLULAR ALTERATION IN THE LIVER) VCM AT LEVELS OF 0.014 OR 0.13 MG/XG BOOY WEIGHT/DAY MAY RESULT IN AN INCREASED INCIOENCE OF BASOPHILIC FOCI OF CELLULAR ALTERATION IN THE LIVER OF FEMALE RATSlO.lSMG VCM/KG BODY WIGHT/ DAY IS A "NO-OBSERVED-ADVERSE-EFFECT-LEVEL" WITH RESPECT TO THE INDUCTION OF TUMOURS IN RATS. DESCRIPTORS ******* PVC)VCHjORALiFEEDING STUDY>RATS)CANCER|CHRONICJEFFECTS)DIET) HELD TERMS DIETARY ADMINISTRATION>CIVO INSTITUTES TNO) REVIEW YEAR 1990 Itam 291 ACCESSION NUTBER 725 FILE LOCATION DOCUMENT TYPE GEN PAPER TITLE OR SLBJECT AUTHOR/AFFILIATION WORKING CONDITIONS AND MEASURES FOR THEIR SANITATION IN THE PRODUCTION AND UTILIZATION OF VINYL CHLORIDE PLASTICS TRIBUKH SL.NONE)TIKH0MIR0VA NP.NONE)LEVIN SV,NONE)KOZLOV LA,NONE) ORIGIN DATE DESCRIPTORS NONE,VOL 10 PP.38-45) 1949 ******* VCH)TOXICITY)PVC)PCB'S) 20867095 ,fG 5 2 0 ^ data search on vcm tor craig elgut Order nud>r 901U9-133245-HIZ -001-001 page 95 set 5 mith 363 of 363 item* HELD TERMS REV1EM YEAR HEPATITXStARG SANIT) 1990 208670SS BFG52015 Item 292 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATIQN ORIGIN DATE DESCRIPTORS JHHHHH REVIEH YEAR 723 GEN JOURNAL THE EFFECT OF REPEATED VINYL CHLORIDE EXPOSURE ON RAT HEPATIC METABOLIZING ENZYMES DU JT,NONE*TSENG NT,NONE*TAMBURRO CH.UNIV OF LOUISVILLE* TOX AND APPLIEDjVOL 62 PP.1-10* 1962 VCM(METABOLISM 1990 Item 293 ACCESSION NUTCER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEH YEAR 721 GEN PUBLICATION TEN CANADIAN CASES OF ANGIOSARCOMA OF THE LIVER IN VINYL CHLORIDE WORKERS DELORME F NONE* NONE,VOL 23 NO.2PP.97-103* 1978 TEN CASES OF ANGIOSARCOMA OF THE LIVER AMONG VINYL CHLORIDE NORKERS FROM A PLANT IN SHAMXNIGAN, QUEBEC, ARE REPORTED. THE AUTHOR INSIST MOSTLY ON THE OCCUPATIONAL HISTORY OF THESE WORKERS AND ON THE MORPHOLOGIC DESCRIPTION OF THE LESIONS. A PATHOGENIC HYPOTHESIS IS SUBMITTED. VCM * ANGIOSARCOMA *HUMAN * EFFECTS * LIVER ANNALES D'ANATOMIE PATHOLOGIQUE * 1990 Item 294 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEH YEAR 712 GEN PAPER VINYL CHLORIDE CONTENT OF SUBCUTANEOUS ADIPOSE TISSUE FROM VINYL CHLORIDE POLYMERIZATION WORKERS KNITTLE JL,NEH YORK UNIV*FONTANARES P,SAHE*DAUM SSAME* SELIKOFF IJ,SAME} NONE,NONE* 1974 SIGNIFICANT LEVELS OF VINYL CHLORIDE MONOMER HERE FOUND IN SUBCUTANEOUS FAT DEPOTS OF NORKERS EXPOSED TO THE GAS DURING THE MANUFACTURE OF POLYVINYL CHLORIDE. THE COMPOUND HAS NOT DETECTED IN A CONTROL GROUP OF UNEXPOSED WORKERS. VCM*ADIPOSEHUMANSEFFECTS BIOACCUMJLATOR (DEPOSITION (CONCENTRATION* 1990 Item 295 ACCESSION NUTOER 711 data search on vca for craig slgil Order nut^ar 901I19-'133245-HIZ -001-001 page 96 set 3 Hith 363 of 363 item FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT Al/THOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR GEN PUBLICATION HEHANGIOSARCOMA AND HEPATOCELLULAR CARCINOMA OF THE LIVER FOLLOWING VINYL CHLORIDE EXPOSURE GOKEL JM,NONELIEBEZEIT ENONE)EDER M,NONE) NONE,VOL 372 NO.3 PP.195-203) 1976 A REPORT IS GIVEN OF THE CLINICAL AND AUTOPSY FINDINGS OF TWO MEN WHO DIED FROM MALIGNANT LIVER NEOPLASM FOLLOWING OCCUPATIONAL EXPOSURE TO VINYL CHLORIDE. THE FIRST PATIENT HAS A 44-YEAR-OLD HAN WITH AN HEHANGIOSARCOMA OF THE LIVER, THE SECOND PATIENT A 67-YEAR-OLD MAN WITH AN HEPATOCELLULAR CARCINOMA. SO FAR AN HEPATOCELLULAR CARCINOMA DUE TO VINYL CHLORIDE HAS NOT YET BEEN OBSERVED IN MAN. ITS OCCURRENCE, HOWEVER, HAS BEEN SUGGESTED FROM THE RESULTS OF ANIMAL EXPERIMENTS. THE CONNECTION OF HEPATOCELLULAR CARCINOMA WITH EXPOSURE TO VINYL CHLORIDE IS DISCUSSED. VCM)ANGIOSARCOMA)LIVER)CANCER)HUMANS(EFFECTS) HEPATOCELLULAR CARCINOMA)VIRCHOH ARCH PATH ANAT) 1990 Item 296 ACCESSION NUTOER 710 FILE LOCATION GEN DOCUHENT TYPE BIBLIOGRAPHY TITLE OR SUBJECT WORLD REGISTER OF CASES OF ANGIOSARCOMA OF THE LIVERIASL) DUE TO VCM AUTHOR/AFFILIATION bemett b,ici) ORIGIN ICI DATE 1990, JANUARY ABSTRACT THIS DOCUMENT IS A REVIEW OF ALL ANGIOSARCOMA DEATHS IN PEOPLE WHO HAVE BEEN EMPLOYED IN A VCM/PVC FACILITY. IT IS UPDATED APPROXIMATELY BI-ANfUALLY. DESCRIPTORS MlHHM VCM) ANGIOSARCOMA) HUMANS )EFFECTS REV1EN YEAR 1992 Item 297 ACCESSION NUtBER 706 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT AUTHOR/AFFILIATION ASSOCIATION OF AN ANGIOSARCOMA OF THE LIVER NITH A HEPATOMA IN A VINYL CHLORIDE WORKER DELORME F,NQNE) ORIGIN NONE,VOL 23 NO.2 PP.105-114) DATE 1978 ABSTRACT THIS REPORT DEALS WITH A 51 YEARS-OLD MAN WHO, FOR 23 YEARS AND 4 MONTHS OF HIS HORKING LIFE, HAD BEEN EXPOSED TO VINYL CHLORIOE VAPORS. AUTOPSY REVEALED A HEPATOMA ASSOCIATED WITH AN ANGIOSARCOMA OF THE LIVER. THE CASE IS THE FIRST EVER TO BE REPORTED IN THE MEDICAL LITERATURE. THIS CASE RAISES DOUBT ABOUT THE THEORY WHICH SUGGESTS THAT THE CARCINOGENIC EFFECT OF VINYL CHLORIDE IN HAN ELICIT A TUMOR OF VASCULAR NATURE. DESCRIPTORS (twmaaa VCM)ANGIOSARCOMA)HUMANS)EFFECTS)LIVER HELD TERMS ANALES D'ANATOMIE PATHOLOGIQUE) REVIEW YEAR 1990 20867037 BFG52016 data search on vcm for craig el$Kt Order nunfcer 901119-133245-HIZ -001-001 page 97 tei 3 with 363 of 363 items 20867098 BFG52017 Item 290 ACCESSION NUTBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS WWI HELD TERMS REVIEW YEAR 704 GEN PUBLICATION SCLERODERMA LIKE SKIN CHANGES,RAYNAUD'S SYNDROME AND ACROOSTEOLYSES IN WORKERS IN THE POLYVINYL CHLORIOE PRODUCING INDUSTRY JUNE S,N0NE(LANGE CE,N0NE| NONE>VOL 97 PP.1922-1923( 1972 VCM(AOL(SYNOROME SCLERODERMAfDTSCK MED NSCHRl 1990 Item 299 ACCESSION NUTBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATIGN ORIGIN DATE DESCRIPTORS **** HELD TERMS REVIEH YEAR 703 GEN PUBLICATION TOXIC TRIGEMINAL DISEASE AND POLYVINYLIDENE CHLORIDE KRIE6ER J,N0NE(HARTER JH,N0NEjHENGUS M,NONE(MEHL J,NONE)ISCH F,NQNE( NONE,VOL 43 PP.64-66) 1971 VCM(AOL(HUMANS|EFFECTS REVUE D`OTO-NEURO-OPHTALMOLOGIE( 1990 Item 300 ACCESSION NUTBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS JHHHHH HELD TERMS REVIEH YEAR 702 GEN PAPER OCCUPATIONAL ACROOSTEOLYSIS (AOL): AN EPIDEMIOLOGIC INVESTIGATION OF A NEH DISEASE AMONG POLYVINYL CHLORIOE SYNTHESIS WORKERS MAGNUSON J,N0NE(DIN1AN BD.NONE(COCK HA,NONE)GIEVER PM,N0NEjNHITEHOUSE lft,N0NE) NONE,PP.621-6221 1969* SEPTEMBER 22-27 VCM{AOL(HUMANS(EFFECTS(EPIDEMIOLOGY INTERNATIONAL CONGRESS ON OCCUPATIONAL HEALTH} 1990 Item 301 ACCESSION NUTBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN 701 GEN PUBLICATION OCCUPATIONALACROOSTEOLYSIS MARKOWITZ SS,N0NE(MC DONALD CJSAME(FETHIERE H,SAME(KER2NER MS,SAME( ARCH DERMATOL,VOL 106 PP.219-223( data search on vcn for craig elgut Order nuober 901119-133245-HIZ -001-001 pegs 90 set 3 with 363 of 363 itens DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 1972* AUGUST OCCUPATIONAL ACROOSTEOLYSIS IS AN UNUSUAL DISEASE IN MUCH AFFECTED PERSONS HAVE SCLEROOERMOID-LIKE LESIONS OF THE SKIN, CONDITIONS SIMILAR TO RAYNAUD'S PHENOMENON, ANO ASYMPTOMATIC, BONY DEFECTS OF THE EXTREMITIES. TO OUR KNOWLEDGE, THE DISEASE IS CONFINED SOLELY TO WORKERS IN THE PLASTICS INDUSTRY, SPECIFICALLY THOSE ENGAGED IN THE PRODUCTION OF POLYVINYL CHLORIDE FROM VINYL CHLORIDE. THE INCIDENCE OF THE DISEASE IS LNtNOHN BUT IS THOUGHT TO OCCUR IN 32 OR LESS OF WORKERS. VCMlACROOSTEOLYSISiSYNDROMEIHUMANSlEFFECTS BR0M4 UNIV>RAYNAUD'S SYNDROME) 1990 Itee 302 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFI LI ATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 697 GEN PUBLICATION OCCUPATIONAL LESIONS OF THE SKIN DUE TO PVC SOTMECK HJ,NONE I NONE,VOL B PP.38-431 1962 TWO CASES OF OCCUPATIONAL LESIONS OF THE SKIN OBSERVED IN THE INDUSTRY MAKING USE OF POLYVINYL CHLORIOES, ARE DEALT WITH. IN THE LIGHT OF TEST RESULTS IT IS SUPPOSED THAT A CQMPLEXE TOXIC ANO ALLERGIC MECHANISM PLAYS A PART, THAT MEANS THAT THE EMULSIFIER WITH ITS STRONG DEGREASING PROPERTIES OR THE SOLVENTS USED MAY CAUSE NOT ONLY AN IRRITATION OF THE SKIN BUT HAY EVEN FURTHER A SENSIBILIZATION TO POLYVINYL CHLORIDE WHICH, GENERALLY, IS NOT CONSIDERED TO BE A SENSITIZER. VCMjSKINlLESIONS WORKERS> HUMAN(EFFECTStSOLVENTS BERUFSOERMATOSEN) 1990 Item 303 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS REVIEW YEAR 694 GEN JOURNAL OCCUPATIONAL ACROOSTEOLYSIS HILSON RH,BFGlMC CORMICK HE,SAMEJTATUM CFNONEiCREECH JLNONE> JAMA,VOL 201 NO.8 PP.S77-58U 1967, AUGUST 21 IN 31 CASES OF ACROOSTEOLYSIS OF THE HANDS OF HORKMEN ASSOCIATED WITH VINYL CHLORIDE (CH2CHCL) POLYMERIZATION PROCESSES, THE OSTEOLYSIS NAS SPECIFIC TO THE DISTAL PHALANGES OF HANDS AND HAS FREQUENTLY ASSOCIATED WITH RAYNAUD'S SYMPTOMS. AFFECTED PERSONNEL RANGED IN AGE FROM 26 TO 47. THE DISORDER IS BELIEVED TO HAVE RESULTEO FROM A COMBINATION OF PHYSICAL INSULT, CHEMICAL INSULT, AND PERSONAL IDIOSYNCRASY. THE SPECIFIC CAUSES ARE UMCN0M4. THE PREVALENCE HAS FOUND TO BE LESS THAN 32 AMONG EMPLOYEES PERFORMING SIMILAR WORK. NO CASES MERE FOUND IN WORKMEN USING OR PROCESSING THE POLYMER OR MANUFACTURING COMMERCIAL RESINS. VCM>AOLHUMAN>EFFECTSNORKERS|EPIOEHIQLOGY 1990 Item 304 20867039 data search on ven for craig algjf Ordar nunfeer 901119-133245-MIZ -001-001 page 99 sat 3 with 363 of 363 itania 20867100 BFG52019 ACCESSION NUMBER 688 FILE LOCATION SEN DOCUMENT TYPE PROCEEDINGS TITLE OR SUBJECT OCCUPATIONAL CARCINOGENESIS AUTHOR/AFFILIATXON MALTONI C ,N0NE ( ORIGIN NONE,VOL 2SERIES NO.322( DATE 1973, APRIL 9-12 ABSTRACT OVERVIEW OF CHEMICAL CARCINOGENESIS AM) ANIMAL STUDIES SHOWING VCM INDUCED CANCER OF THE LIVER (ANGIOSARCOMA) AND ZYMBAL GLANO. DESCRIPTORS miiii VCM} RATS iANGIOSARCOMA iZYFCAL GLAND (TUMORS ( CARCINOGENICITY (INHALATION( CHRONIC {EFFECTS HELD TERMS INTERNATIONAL CONGRESS ON OCCUPATIONAL HEALTH) REVIEW YEAR 1990 Itan 305 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATXON ORIGIN OATE ABSTRACT DESCRIPTORS REVIEW YEAR 686 GEN JOURNAL ACUTE INHALATION TOXICITY OF VINYL CHLORIDE TO LABORATORY ANIMALS MASTROMATTEO E,NONE (FISHERAM,NONE (CHRISTIE H,NONE(OANZIGER H,NONE( J OF AIHAVOL 21 PP.394-398) 1960 IRRITATION AND SYMPTOMS RELATING TO NARCOSIS ANO DEATH MERE OBSERVED OVER CONCENTRATIONS OF 10-402 IN MICE,RATS AND GUINEA PIGS. VCM,INHALATION (MICE (RATS (GUINEA PIGS,NARCOSIS 1990 Itan 306 ACCESSION NUWER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATXON ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERNS REVIEW YEAR Itea 307 685 GEN PUBLICATION CHRONIC ORAL TOXICITY TO RATS OF A VINYL CHLORIOE-VINYL ACETATE COPOLYMER SMYTH HF,NONE(WEIL CS,SAME( TOX AND APPLIED,VOL 9 PP.501-SD4> 1966 STARTING IN 1944, ALBINO RATS OF BOTH SEXES CAGED TOGETHER NERE MAINTAINED FOR TWO YEARS UPON DIETS CONTAINING 1.52 AND 122 OF A VINYL CHLORIDE-VINYL ACETATE COPOLYMER. NO EFFECTS ATTRIBUTABLE TO THE RESIN WAS FOUNO. PVC(VCM(VDC(CARCINOGENICITY ,ORAL,RATS(CHRONIC(EFFECTS DIET( MELLON INSTITUTE) 1990 ACCESSION NUTSER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT 684 GEN PUBLICATION ONE-YEAR TIME SEQUENCE INHALATION TOXICITY STUDY OF VINYL CHLORIDE IN RATS: I. GROWTH, MORTALITY, HAEMATOLOGY, CLINICAL CHEMISTRY AND ORGAN HEIGHTS data search on vcn for craig algut Order nuifcer 90U19-133245-HIZ -001-001 page 100 set 3 with 363 of 363 items 20867101 BFG52020 AUTHOR/AFFILIATI0N ORIGIN DATE ABSTRACT DESCRIPTORS HELO TERMS REVIEW YEAR FERON VJ,NONEKRUYSSE A,N0NE(TIL HP,NONE) NONE,VOL 13 PP.Z5-2B) 1979 HISTAR RATS MERE EXPOSED TO ATMOSPHERES CONTAINING 0 (CONTROL) OR 5000 PPM VINYL CHLORIDE MONOMER (VCM), 7 HR/DAY, 5 DAYS/HEEK, FOR A PERIOD OF 52 WEEKS. AFTER 4,13,26 AM) 52 WEEKS EACH TIME 10 RATS/SEX/GROUP HERE KILLED AND SUBJECTED TO EXTENSIVE EXAMINATIONS. THE PRESENT PAPER DEALS WITH GROWTH, MORTALITY, HAEMATOLOGY, CLINICAL CHEMISTRY AND ORGAN HEIGHTS. THE PRESENT STUDY DID NOT PRODUCE OBVIOUSLY SUITABLE PARAMETERS FOR EARLY DIAGNOSING "VCH-DISEASE" IN MAN. VCM (RATSINHALATION(CHRONIC)DETERMINATION DIAGNOSIS! TOXICOLOGY! 1990 Item 30B ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 663 GEN PUBLICATION ANESTHESIA XXVII: NARCOSIS NITH VINYL CHLORIDE OSTER RH,NONElCARR CJ,NONEiKRANTZ JC,NONEi NONE,VOL 8 PP.359-361! 1947, JULY NARCOSIS AND CARDIAC ARRHYTHMIA OBSERVED IN DOGS EXPOSED TO 7 TO 50X VCM. VCM)CARDIAC ARRHYTHMIA!NARCOSXS(INHALATION (ACUTE )DOGS ANESTHESIA( 1990 Item 309 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 662 GEN PUBLICATION ONE-YEAR TIME-SEQUENCE INHALATION TOXICITY STUDY OF VINYL CHLORIDE IN RATS : II. MORPHOLOGICAL CHANGES IN THE RESPIRATORY TRACT,CERUMINOUS GLANDS, BRAIN,KZDNEYS,HEART AND SPLEEN. FERON VJ,NONE|KROES R,NONE( NONE,VOL 13 PP.131-141! 1979 HISTAR RATS WERE EXP06ED TO ATMOSPHERES CONTAINING 0 (CONTROL) OR 5000 PPM VINYL CHLORIDE MONOMER (VCM), 7 HR/DAY, 5 DAYS/HEEK, FOR A PERIOD OF 52 WEEKS. AFTER 4,13,26 AND 52 MEEKS EACH TIME 10 RATS/ SEX /GROUP MERE KILLEO AND SUBJECTED TO EXTENSIVE EXAMINATIONS. THE PRESENT PAPER OESCRIBES THE MORPHOLOGICAL CHANGES OBSERVED IN THE RESPIRATORY TRACT, CERUMINOUS GLANDS,BRAIN, KIDNEYS,HEART AND SPLEEN. THE VCM-EFFECTS INCLUDED INCREASED DEGREE OF TUBULAR NEPHROSIS, MILO FOCAL DEGENERATION OF THE KYOCARD, AND INCREASED HAEMATOPOIETIC ACTIVITY IN THE SPLEEN. IN ADDITION, PRIMARY TUMOURS HERE FOUNO IN THE BRAIN (EPENDYMOMA),LUNGS (PAPILLARY ADENOMA AND MESENCHYMAL TYPE OF TUMOUR), CERUMINOUS GLANDS (MAINLY KERATINIZED SQUAMOUS CELL CARCINOMAS), ANO NASAL CAVITY (CARCINOMAS OF THE OLFACTORY EPITHELIUM, CARCINO-SARCOMAESTHESIONEUROEPITHLIOKA). VCM!INHALATION(RATS(CHRONIC(CARCINOGENICITY(RESPIRATORY EFFECTS RESPIRATORY TRACT! TOXICOLOGY! 1990 data search on vcm for eraig tlgjf Order nuitar 901119-133245-HIZ -001-001 page 101 sat 3 with 363 of 563 items 20867102 BFG52021 Item 310 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR Item 311 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS REVIEH YEAR Item 312 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 661 GEN PUBLICATION ONE-YEAR TIME-SEQUENCE INHALATION TOXICITY STUDY OF VINYL CHLORIDE IN RATS: III. MORPHOLOGICAL CHANGES IN THE LIVER FERON VJ,NONEfSPIT BJtNQNE (IttCL HR,NONE)KROES R,NONE| NOtC>VOL 13 PP.193-159) 1979 HISTAR RATS MERE EXPOSED TO ATMOSPHERES CONTAINING 0 (CONTROL) OR SOOO PPM VINYL CHLORIDE MONOMER IVCN), 7 HR/DAY, 5 DAYS/WEEK* FOR A PERIOD OF 2 MEEKS. AFTER 9,13,26,52 MEEKS EACH TIME 10 RATS/SEX/ GROUP HERE KILLED AND SUBJECTED TO EXTENSIVE EXAMINATIONS. THE PRESENT PAPER DESCRIBES THE MORPHOLOGICAL CHANGES FOUND IN THE LIVER. THE MAJOR PARENCHYMAL CHANGES COMPRISED SMELLING AND MALFORMATION OF MXTOCHONORIA* AN INCREASEO AMOUNT OF SMOOTH ENDOPLASMIC RETICULUM* NECROSIS,NUCLEAR AND CELLULAR POLYMORPHISM OF KEPATOCYTES, "FOCI OF CELLULAR ALTERATION", NEOPLASTIC NOOULES AND HEPATOCELLULAR CARCINOMAS. A REDUCED GLUCOSE -6-PHOSPHATASE ACTIVITY IN HEPATOCYTES ANO A STRON SINUSOIDAL ACTIVITY OF ALKALINE PHOSPHATASE MERE FOUNO HITHIN "FOCI OF CELLULAR ALTERATION". THE NON-PARENCHYMAL ALTERATIONS INCLUDED FOCAL DILATATION OF SINUSOIDS, FOCAL PROLIFERATION OF ATYPICAL SINUSOIOAL CELLS AND MULTICENTRIC ANGIOSARCOMAS. THE EFFECTS OF VCM ON IDE HEPATIC PARENCHYMA SEEMED TO PRECEDE THOSE ON THE HEPATIC STROMA. VCM^INHALATION}RATStCHRONIC^CARCINOGENICITY)LIVER TOXICOLOGY 1990 660 GEN JOURNAL EFFECTS OF SINGLE AND REPEATEO EXPOSURES OF HUMANS AND RATS TO VINYL CHLORIDE LESTER D,NONE)GREEM)ERG LA,NONE)ADAMS HR,NONE) J OF AIHA,VOL 29 PP.265-275) 1963, MAY-JUNE RATS EXPOSED EIGHT HOURS DAILY TO VINYL CHLORIDE AT CONCENTRATIONS OF 2 VCMRATS) HUIANS) INHALATION )SUBCHRONIC 1990 679 GEN PUBLICATION NOWEOPLASTIC EFFECTS OF VINYL CHLORIDE IN MOUSE LUNG SUZUKI Y,NEH YORK UNIV) ENVIRONMENTAL RESEARCH,VOL 21 PP.235-253) I960 IN A PREVIOUS STUDY, A HIGH INCIDENCE OF PULMONARY TUMORS IALVEOLOGENIC NEOPLASIA IN MOUSE LUNG EXPOSED TO VINYL CHLORIDE AT HEAVY DOSE (2500 AND 6000 PPM) FOR LONG DURATIONS (5 AM) 6 MONTHS) data search on vcn for craig elpjt Order ntanber 90U19-133265-WIZ -001-001 peg* 102 set 3 with 363 of 363 item DESCRIPTORS HELD TERMS REVIEW YEAR HAS REPORTED <Y. SUZUKI, 1978,ENVIRON.RES. 16,285-301). IN THE PRESENT STlY, NOtMEOPLASTIC EFFECTS IN MOUSE LUNG HERE INVESTIGATED BY LIGHT AND ELECTRON MICROSCOPY. VCM)INHALATION)MICE)LUNG)CARCINOGENICITYjCHRONIC>EFFECTS CITY LNIV OF NEH YORK) 1990 Itan 313 ACCESSION NUTOER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELO TERMS REVIEW YEAR 676 GEN PUBLICATION INHALATION PHARMACOKINETICS BASED ON GAS UPTAKE STUDIES BOLT HM,N0NEiFILSER JG.NONEjBUCHTER A,NONE) NONE,VOL 66 PP.213-228) 1981 AFTER COMPARING A 2-HR EXPOSURE TO 5 PPM VCM WITH TWO 50 PPM VCM PEAKS FOR 5 MINUTES EACH IN THE RHESUS HOTKEY, THE AUTHORS CONCLUDED THAT REGAROLESS OF THE EXPOSURE PROFILE THE AMOUNT OF REACTIVE METABOLITES FORMED FROM VCM MOULD SOLELY BE A FUNCTION OF MEAN VCM CONCENTRATION (AIR) OVER TIME. VCM)INHALATION)PHARMACOKINETICS)METABOLISM)MONKEY PEAK CONCENTRATIONS)RHESUS MONKEY) ARCH TOXICOL) 1990 Iten 316 ACCESSIONNUTOER 677 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT PHARMACOKINETICS OF VINYL CHLORIDE IN THE RAT AUTHOR/AFFZLIATION BOLT HM,NQNE)LAIB RJ,NONE)KAPPUS H,NONEiBUCHTER A,NONE) ORIGIN NONE,VOL 7 PP.179-188) DATE 1977 ABSTRACT PHARMACOKINETIC ANALYSIS SHOWS THAT NO SIGNIFICANT CUMULATION OF VINYL CHLORIDE OR ITS MAJOR METABOLITES IS TO BE EXPECTED ON REPEATED ADMINISTRATION OF VINYL CHLORIDES. THIS MAY BE CONSISTENT WITH THE THEORY THAT A REACTIVE,SHORTLY LIVING,METABOLITE WHICH OCCURS IN LOW CONCENTRATION ONLY, MAY BE RESPONSIBLE FOR THE TOXIC EFFECTS OF VINYL CHLORIOE. DESCRIPTORS VCM)PHARMACOKINETICS}tTABOLISM)RAT)INHALATION HELD TERMS TOXICOLOGY)INSTITUTE OF TOXICOLOGY)UNIV OF TUBINGEN)INSTITUTE OF OCCUPATIONAL AND SOCIAL MEOICINE)UNIV OF COLOGNE) REVIEW YEAR 1990 Itee 315 ACCESSION NUWER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE 676 GEN PUBLICATION DISPOSITION OF 11,2-160 VINYL CHLORIOE IN RAT BOLT HM,NONE)KAPPUS H,NOt)BUCHTER ANONE)BOLT H,NONE) NONE,VOL 35 NO.3 PP.153-162) 1976 20867103 BFG52022 data search on van for craig elgut Order nunber 901119-133245-NIZ -001-001 page 103 set 3 with 363 of 363 itees ABSTRACT DESCRIPTORS HELD TERMS REV1EH YEAR IMMEDIATELY AFTER EXPOSURE* HIGHEST RADIOACTIVITY LEVELS MERE OBSERVED IM LIVER AND KIDNEY. THE RADIOACTIVE METABOLITES OF 14C-VINYL CHLORIDE MERE RAPIDLY EXCRETED* LARGELY BY TOE KIDNEYS. EXCRETION OF RADIOACTIVITY IN THE URINE MAS 69.4 PLUS OR MINUS 2.6 HITHIN 24 HR. smshkks VCM*INHALATION |METABOLISM*RAT DISPOSITION* ARCH TOXICOL* 1990 Item 316 ACCESSION NUFBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELO TERMS REVIEM YEAR 67S GEN PUBLICATION PHARMACOKINETICS OF VINYL CHLORIDE IN THE RHESUS HOTKEY BUCHTER A,NONE*FILSER JG*NONE*BOLT HM,N0NE*PETER H,N0NE* NONE*VOL 6 PP.33-36* 1980 THE METABOLIC ELIMINATION OF VINYL CHLORIDE IN RHESUS HOTKEYS IS A OOSE-OEPETOENT .SATURABLE PROCESS* AS IN RATS. BELQH 200-300 PPM OF VINYL CHLORIDE (VC) IN ATMOSPHERE* ELIMINATION OBEYS A FIRST-ORDER LAM* THE CLEARANCE RATE IS MUCH CLOSER TO THAT FOUND IN MAN THAN THE VALUES FOR RATS, MICE AND GERBILS. THE MAXIMAL VELOCITY OF METABOLIC ELIMINATION OF VC AT HIGH CONCENTRATIONS IN RHESUS HOTKEYS IS ONLY ABOUT HALF OF RATS MHEN RELATEO TO KG BODY HEIGHT. IT IS SUGGESTED THAT RHESUS HOTKEYS MIMIC THE QUANTITATIVE ASPECTS OF VC METABOLISM BETTER THAN RATS OR MICE. VCM *INHALATION *MONKEY(PHARMACOKINETICS *METABOLISM RHESUS MOTKE Y * TOXICOLOGY LETTERS* 1990 Item 317 ACCESSION NUtBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILJATI0N ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEM YEAR 674 GEN PUBLICATION STUDIES ON THE METABOLISM OF VINYL CHLORIDE ANTHEILER H>NQNE* NONE>VOL 17 PP.217-219* 1976 VINYL CHLORIDE (VCH) IS NOT CARCINOGENIC BY ITSELF IT IS BIOACTIVATED TO THE HIGHLY REACTIVE ALKYLATING OXIRANE CHLOROETHYLENE OXIDE. FURTHER METABOLISM, APPARENTLY, LEADS VIA AN INTERACTION OF THE PRIMARY ALKYLATING METABOLITES MITH 6LUTATHI0N TO S-(2-CARBOXYMETHYL )-CYSTINE AND THIODIACETIC ACID NHICH ARE ELIMINATED MITH THE URINE. VCM (METABOLISM S-l2-CARBOXYMETHYL)-CYSTEINE(ENVIROWENTAL HEALTH PERSPECTIVES* CHLOROETHYLENE OXIDE* THIODIACETIC ACID* 1990 Item 318 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT 673 GEN JOURNAL RISKS TO THE OFFSPRING FROM PARENTAL OCCUPATIONAL EXPOSURES 208S7104 BFG52023 data search on van for craig elgjt Order nurier 90U19-133245-HIZ -001-001 page 104 set 3 with 363 of 363 item AUTHOR/AFFILIATION ORIGIN OATE ABSTRACT DESCRIPTORS mmmmmmu REVIEN YEAR HAAS JF,N0NEiSCHOTTEHFELD D,N0NE) JOURNAL OF OCCUPATIONAL MEDICINE ,VOL 21 NO.9 PP.607-613* 1979, SEPTEFBER VCM IS DISCUSSED AS ONE OF SEVERAL COMPOUNDS HHICH MAY POSE A REPRODUCTIVE RISK. VCM)REPRODUCTION)TERATOGENICITY )MUTAGENICITY)HUMAN) EFFECTS )CHRQMOSOMAL ABERRATION 1990 Item 319 ACCESSION NUFBER 672 FILE LOCATION GEN DOCUMENT TYPE TITLE OR SUBJECT PUBLICATION THE ROLE OF RESPIRATION IN VINYL CHLORIDE MONOMER EXCRETION IN RATS AUTHOR/AFFILIATION ZUCCATO E,NONE)HARCUCCI F.NONEjMUSSINI E,N0NE) ORIGIN NONE,VOL S PP.213-217* DATE 1980 ABSTRACT 1,5 AND 10 MG/KG VINYL CHLORIDE MONOMER (VCM) IN AQUEOUS SOLUTION HERE INJECTED I.V. INTO HALE RATS NITH CANNULATED TRACHEAS. RESPIRATORY ACTIVITY NAS REGULATED TO PERMIT INVESTIGATION OF THE EFFECT OF MODIFYING PULMONARY VENTILATION ON VCM EXCRETION IN BLOOD AND EXPIRED AIR ASSAYED AT DIFFERENT INTERVALS FOR VCM. VCM EXCRETION RATE HAS FOUND TO BE OIRECTLY PROPORTIONATE TO PULMONARY VENTILATION. HHEN RESPIRATION HAS STOPPED FOR 1 MIN AFTER VCM INJECTION, THERE NAS NO DECREASE IN BLOOD VCM, THE MAIN ROUTE OF ELIMINATION OF I.V. INJECTED VCM THUS BEING PULMONARY. DESCRIPTORS xmimmx VCM)LUNGS)RATS)IV)ELIMXNATION HELO TERMS DISPOSITIONlTOXICOLOGY LETTERS) REVIEW YEAR 1990 Itee 320 ACCESSION NUT-BER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFI LIATION ORIGIN DATE DESCRIPTORS REVIEW YEAR 671 GEN PAPER METABOLISM OF VINYL CHLORIDE HATANABE PG,DOH CHEMICAL CO)HEFNER RESAME)MCGOWAN GR,SAME)GEHRING PJ,SAME) DON CHEMICAL CO,PRESENTED AT COMBINED CLINICAL STAFFS (NIH)) 1974, NOVEMBER 14 VCM(INHALATION )METABOLISM 1990 Itee 321 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 670 GEN PAPER VINYL CHLORIDE INDUCED DEPRESSION OF HEPATIC NON-PROTEIN SULFHYORYl CONTENT AND EFFECTS ON BRGMOSULPHALEIN (BSP) HATANABE PG.DOH CHEMICAL CO)HEFNER RE>SAME)GEHRING PJ,SAME) DOM CHEMICAL CO 1976 RATS HERE EXPOSED TO ATMOSPHERES OF 2000,1000,250,150,50 AND 10 PPM VINYL CHLORIDE (VC) FOR 1-7 HOURS TO DETERMINE THE EFFECT OF VC ON THE HEPATIC NON-PROTEIN SULFHYORYL CONTENT. EXPOSURE TO 20867105 BFG52024 data search on vcm for craig llgit Order number 90U19-133245-HIZ -001-001 page 105 aat 3 nith 363 of 363 items DESCRIPTORS HELO TERMS REVIEW YEAR 2000,1000,250 AND 150 PPM VC CAUSEO A PROGRESSIVE DEPRESSION OF THE HEPATIC NON-PROTEIN SULFHYDRYL CONTENT. FOLLOWING EXPOSURE TO 50 PPH VC FOR 7 HOURS THE DEPRESSION NAS INCONSISTENT, AND NO DEPRESSION HAS OBSERVED AFTER 10 PPH VC FOR 7 HOURS. ALSO, EXPOSURE TO 1000 PPM VC 010 NOT ALTER THE SERUM CLEARANCE OF BROMSULPHALEIN (BSP) ******* VCMIINHALATION t RATS(METABOLISM DISPOSITION(CLEARANCE* 1990 Item 322 ACCESSION NUTBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELO TERMS REVIEH YEAR 669 GEN PUBLICATION HEPATIC KACROHOLECULAR BINDING FOLLOWING EXPOSURE TO VINYL CHLORIDE HATANA0E PG,D0W CHEMICAL COtZEHPEL JA,SAME(PEGG DG,SAMEIGEHRING PJ,SAME> TOX AND APPLIED,VOL 94 PP.571-579( 1978 COVALENT BINDING OF RADIOACTIVITY TO HEPATIC MACROMOLECULES IN RATS EXPOSED TO 1AC-LABELED VINYL CHLORXOE (VC) HAS STUDIED TO DETERMINE IF VC-XNOUCED CARCINOGENESIS MAY BE RELATED TO ELECTROPHILIC ALKYLATION OF MACROMOLECULES IN VIVO. MALE SPRAGUE-DAHLEY RATS HERE EXPOSED TO 1,10, 25,50,100,250,500,1000, OR 5000 PPM OF 14C VC FOR 6 HR. FOLLOWING EXPOSURE,RADIOACTIVITY COVALENTLY BOUND TO HEPATIC MACROMOLECULES AND PURIFIED NUCLEIC ACID (RNA,DNA) WAS DETERMINED. THE TOTAL AMOUW OF 14C VC METABOLIZED AND HEPATIC GLUTATHIONE (GSH) CONTENT HERE ALSO DETERMINED. THE TOTAL AMOUNT OF RADIOACTIVITY BOUND TO MACROMOLECULES IN THE LIVER DIO NOT INCREASE PROPORTIONATELY TO THE INCREASE IN THE EXPOSURE CONCENTRATION OF VC. A DISPROPORTIONATE OECREASE IN HACROMOLECULAR BINOING HAS OBSERVED AS THE CONCENTRATION OF VC INCREASED. THE COVALENT BINOING TO HEPATIC MACROMOLECULES HAS RELATED TO THE AMOUNT OF VC METABOLIZEO. AT EXPOSURES GREATER THAN 50PPM, THE AMOUNT OF 14C BOUND TO MACROMOLECULES IN THE LIVER CORRELATES WITH INDUCTION OF HEPATIC ANGIOSARCOMA. THERE NAS NOT DETECTABLE BINDING OF RADIOACTIVITY TO EITHER DNA OR RNA IN THE LIVER. HEPATIC GLUTATHIOTC CONTENT HAS SIGNIFICANTLY DEPRESSED ONLY AT EXPOSURE CONCENTRATIONS GREATER THAN 100PPM. VCM(METABOLISM(LIVER(INHALATION(RATS MACROMOLECULAR BINDING(COVALENT BINOING 1990 Item 323 ACCESSION NUt-BER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORSnaanauM HELO TERMS REVIEH YEAR 660 GEN PUBLICATION A PROCEDURE FOR PREPARING 14C-LABELEO VINYL CHLORIDE WAGNER Eft,NONEjMUELOER *+i,NONE( NONE,VOL 246PP.152-153} 1975, JANUARY 31 VCM SYNTHESIS)RADIOLABELED (AWALS OF THE NEW YORK ACADEMY OF SCIENCES 1990 Item 324 20867106 BFG52025 data search on vce for craig elfpjt Order meter 901119-133245-NIZ -001-001 page 106 set 3 with 363 of 563 itau ACCESSION NUfSER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATI0N ORIGIN OATE ABSTRACT DESCRIPTORS HELO TERMS REVIEW YEAR 667 GEN PUBLICATION CYTOCHROME P-450 AM) THE METABOLISM OF VINYL CHLORIDE SALMON AG*ICX| NONE*VOL 2 NO-2 PP.109-114) 1976 THE OXIDATION OF VINYL CHLORIDE TO NON-VOLATILE PRODUCTS IS DEPENDENT ON NADPH AND MICROSOMAL ENZYMES. THE ADDITION OF VINYL CHLORIDE TO MICROSOMES CAUSES A TYPE 1 SPECTRAL SHIFT* SIMILAR TO THAT SEEN FOR PHENOBARBETAL!11).WHICH INDICATES THE DIRECT INVOLVEMENT OF A CYTOCHROME P-450 SPECIESjTHIS DIFFERENCE SPECTRUM IS CHARACTERISTIC OF SUBSTRATE BINDING TO THIS TYPE OF ENZYME. A GLUTATHIONE CONJUGATE IS PROBABLY FORMED* PERHAPS VIA A REACTIVE INTERMEDIATE. VCMlMETABOLISMllN VITRO(RATS(LIVER CANCER LETTERl 1990 Itee 325 ACCESSION NUtBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS HELD TERMS REVIEW YEAR ***** Itee 326 666 GEN JOURNAL A GAS-CHROMATOGRAPHIC METHOD FOR THE PREPARATION OF 14C-LABELED VINYL CHLORIDE WAGNER ER*DOH CHEMICAL COlMUELDER Mt*SAME{HATANABE PG,SAME*HEFNER RE *SAME) BRAUN HHSAME(GEHRING PJxSAME( NONE,VOL 11 NO.4 PP.535-542) 1975 VCM SYNTHES1S)RADI0 LABELED) J OF LABELLED COM>OLNDS) 1990 ACCESSION NLfrBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN OATE DESCRIPTORS ***** HELO TERMS REVIEW YEAR Itee 327 665 GEN JOURNAL ACTIVATIN OF VINYL CHLORIDE TO COVALENTLY BOUND METABOLITES: ROLES OF 2-CHLOROETHYLENE OXIDE AND 2-CHLOROACETALDEHYDE GUENGERXCH FP*NONE(CRAWFORD Mi*NONE(HATANABE PG*NONE) NONE,VOL 18 NO.23 PP.5177-5162) 1979 VCM(METABOLISM(IN VITRO(RATS(LZVER COVALENT BINDING)ACTIVATION (2-CHLOROETHYLENE OXIDE(2-CHLOROACETALDEHYDE(BIOCHEMISTRY 1990 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT 664 GEN PAPER TESTIMONY: PHARMACOKINETICS OF VINYL CHLORIDE 20867107 BFG52026 data search on vcm for craig alj^jt Order fembar 901119-133245-MIZ -001-001 page 107 cai 3 with 363 of 363 itans AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** HELD TERMS REVIEW YEAR GEHRING PJ,D0H CHEMICAL C0 DON CHEMICAL CO,FOR HEARING ON ERA'S PROPOSED STANDARD FOR VINYL CHLORIDE I 1976, FEBRUARY 2 USE OF PHARMACOKINETICS IN RISK ASSESSMENT. EXTRAPOLATION OF RODENT DATA TO MAN. VCM AN EXAMPLE. VCMiINHALATIONiCARCINOGENICITY > RATS)HUMANS INCIDENCE)LOW OOSE EXTRAPOLATION 1990 Item 320 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELO TERMS REVIEM YEAR 663 GEN JOURNAL ACRO-OSTEOLYSIS OCCURRING IN HEN ENGAGED IN THE POLYMERIZATION OF VINYL CHLORIDE HARRIS DK,ZCIADAMS HGF,SAME> NONE,VOL 3 PP.712-714) 1967 TWO CASES OF ACRO-OSTEOLYSIS OCCURRING IN MEN ENGAGED IN THE POLYMERIZATION OF VINYL CHLORIDE ARE DESCRIBED. THE BONES AFFECTED HERE THE TERMINAL PHALANGES OF THE FINGERS AND THE SACROILIAC JOINTS, BUT IN ONE CASE THE PATELLA AND IN THE OTHER THE PHALANGES OF THE FEET MERE INVOLVED. THE CONDITION MAS ACCOMPANIED BY RAYNAUD'S PHENOMENON AND SKIN LESIONS. IT MOULD SEEN THAT THIS CONDITION IS PROBABLY A SELF-LIMITING DISEASE. ACROOSTEOLYSIS)VCM)HLMAN)EFFECTS BRITISH MEDICAL JOURNAL 1990 Item 329 ACCESSION NUfBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEM YEAR 647 GEN BOOK PERCUTANEOUS ABSORPTION OF VINYL CHLORIDE HEFNER RE,NONE)NATANABE PG>NONEiGEHRXNG PJ,NONE) TOX AND APPL1ED,V0L 34 PP.529-532) 1975 PERCUTANEOUS ABSORPTION OF 14C-LABELED VINYL CHLORIDE (VC) MAS EXAMINED IN MALE RHESUS MONKEYS. TWO HOTKEYS HERE EXPOSED (WHOLE BODY, EXCLUDING THE HEAD) TO ATMOSPHERES CONTAINING 7000 AND 600 PPM OF VC FOR 2.0 ANO 2.S IIR,RESPECTIVELY. THE AMOUNT OF VC ABSORBED AT 7000 AND BOO PPM HAS 0.023 AND 0.312 OF THE RESPECTIVE TOTAL VC AVAILABLE FOR ABSORPTION. THE MAJORITY OF THE VC ABSORBED NAS ELIMINATED BY THE LUNGS. VCMlABSORPTIONiSKIN ATMOSPHERIC EXPOSURE)PERCUTANEOUS 1995 Itan 330 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT 646 GEN PUBLICATION HEPATIC LESIONS CAUSED BY VINYL CHLORIDE MONOMER IN HUMANS: STUDY OF EI6HT CLINICOPATHOLOGICAL 20867108 BFG52027 data search on vcm -for craig alf^jt Order nuifcer 901119-133245-HIZ -001-001 paga 100 sat 3 with 363 of 363 items BFG52028 CASES AUTHOR/AFFILIATION PIALAT J,NONE)PASUIER BN0NE|PAHN N,NQNE)KOPP N,N0NE) ORIGIN NONE,VOL 27NO.6 PP.361-375) DATE ABSTRACT 1979 SIX HEPATIC ANGIOSARCOMAS ONE HEPATOMA AND ONE HEPATIC FIBROSIS WITH PORTAL HYPERTENSION IN PATIENTS CHRONICALLY EXPOSED TO VINYL CHLORIDE MONOMER (VCM) ARE REPORTED. THE INDUSTRIAL METHODS OF SYNTHESIS AND CURRENT KNOHLEDGE CONCERNING THE CARCINOGENIC ROLE OF VCM ARE REVIENEO. HISTOGENETIC AND PATHOGENETIC CONCETPS OF FIBROSIS AND ANGIOSARCOMAS OF LIVER ARE EXPOSED. DESCRIPTORS ******* VCM)ANGIOSARCOMA>LIVER|CANCER)HUMAN)EFFECTS HELD TERMS ARCH ANATCYTOL PATH REVIEW YEAR 1990 Item 331 ACCESSION NUMBER 619 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT INVESTIGATION OF THE DISEASES PROOUCED BY VINYL CHLORIDE AUTHOR/AFFILIATION SUCIU I,NONE) ORIGIN NONE,VOL 15 PP. 967-76) DATE 1963, AUGUST DESCRIPTORS **** VINYL CHLORIDE)TOXICITY HELD TERMS LIVER DAMAGEiMEDICINA INTERNA (BUCHAREST)) INSTITUTE OF HYGIENE OF CLUJ) COttlENTS rt4J(84) CLASSIC EARLY PAPER ASSOCIATING VCM EXPOSURE HITH BOTH LIVER AND SCLERODERMAL LIKE EFFECTS. REVIEW YEAR 1990 Itan 332 ACCESSION NUTOER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ****** HELD TERMS REVIEW YEAR 616 GEN JOURNAL ANGIOGRAPHIC AND RADIONUCLIDE CHARACTERISTICS OIF HEPATIC ANGIOSARCOMA FOUND IN VINYL CHLORIDE WORKERS WHELAN JG.LNIV OF LOUISVILLE)CREECH JL.NONE)TAMBURRO CH,NONE) NONE,VOL 118 NO.3 PP.549-557) 1976, MARCH VINYL CHLORIDE)ANGIOSARCOMA(LIVER ANGIOGRAPHY)LIVER SCANS)RADIOLOGY 1990 Item 333 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SLAJECT AUTHOR/AFFILIATION ORIGIN DATE 600 GEN JOURNAL THE PATHOLOGY OF 111 CAES OF PRIMARY HEPATIC MALIGNANCY COLLECTED IN THE LIVERPOOL REGION CRUICKSHANt AH,NONE) NONE,VOL 14 PP.120-131) 1961, MARCH data search on vcm for craig el$pjt Order number 901119-133245-NIZ -001-001 page 109 set 3 nith 363 of 363 items ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR the clinical recoros and preserved specimens of hi cases of primary malignant disease of the LIVER HAVE BEEN ANALYSED. ALL MERE DIAGNOSED IN THE MERSEYSIDE AREA> CHIEFLY IN LIVERPOOL AN0 BIRKENHEAD. AM) ALL BUT NINE MERE EUROPEANS. NECROPSY HAS DONE IN 89. THE TUMOURS CONSISTEO OF 108 CARCINOMAS. THO SARCOMAS. AND ONE MIXED TUMOUR. LIVER CELL CARCINOMA HAS NEARLY FOUR TIMES MORE FREQUENT THAN CARCINOMA OF THE INTRAHEPATIC BILE DUCTS. BOTH TYPES HERE COMMONER IN MALES. THE DIFFERENCE BETWEEN THE SEXES BEING GREATER IN THE CASE OF LIVER CELL CARCINOMA. PREOISPOSINS CONDITIONS INCLUDED PORTAL CIRRHOSIS. HAEMOCHROMATOSIS. AND CYSTIC MALFORMATIONS OF BILE DUCTS. THE GROSS ANO MICROSCOPIC APPEARANCES ARE DESCRIBED AND THE PATHOLOGICAL EFFECTS DISCUSSED. LIVER CELL CARCINOMA TENOS TO INVADE AND PERMEATE VEINS HITHIN THE LIVER BUT SEEMS. NEVERTHELESS. TO REMAIN LIMITED TO THE LIVER FOR LONGER THAN CARCINOMA OF THE INTRAHEPATIC BILE DUCTS. LIVER CELL CARCINOMA IS MORE CHARACTERISTIC MICROSCOPICALLY. THE COffUNEST OCCUPATION AMONG THE HALE CASES HAS SEAFARER. kmwmmkm VCM)LIVER)CANCER)HUMAN)EFFECTS J.CLIN.PATH.)UNIV OF LIVERPOOL) 1990 Item 334 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN OATE DESCRIPTORS REVIEN YEAR 599 GEN PUBLICATION OCCUPATIONAL ACROOSTEOLYSXS - A CLINICAL INVESTIGATION OF POLYVINYL CHLORIDE SYNTHESIS HORKERS DINHAN BD.UNIV OF MICHIGAN)DODSON VN.SAME)MAGNUSON HJ.SAME>HHXTEHOUSE HM SAME) UNKNOWN 1969 VCM t AOL)HUMAN)EFFECTS 1990 Item 335 ACCESSION NUWER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ******* HELO TERMS REVIEH YEAR 595 GEN JOURNAL MUTAGENICITY OF VINYL CHLORIDE.VINYLIDENE CHLORIDE AND CKLOROPRENE DftEVON C.NQNE )KURQKI T.SAME) NONE.VOL 67 PP.173-182) 1979 VCM HAS MUTAGENIC BUT VDC AND CHLOROPRENE HERE NOT. VCM)MUTAGENXCITY)IN VITRO)CHLOROPRENE)VDC IARC) MUTATION RESEARCH) 1990 IN V79 CHINESE HAMSTER CELLS Item 336 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT * 594 GEN JOURNAL CARCINOGENICITY OF CHLOROETHYLENE OXIDE.AN ULTIMATE REACTIVE METABOLITE OF VINYL CHLORIDE. AND BIS(CHLOROMETHYL )ETHER AFTER SUBCUTANEOUS ADMINISTRATION ANO IN INITIATION-PROMOTION EXPERIMENTS IN MICE ZOgfiZUG BFG52029 data search on vcm for craig alf^jt Ordar nunbar 901U9-133245-HIZ -C01-0Q1 page 110 sat 3 with 363 of 363 itans AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT ZAJDELA F>NONE>CROISY ASAMJBARBIN A,SAME)KALAVEILLE C,SAHETOMATIS L, SAMElBARTSCH H,SAME CANCER RESEARCH,VOL 40 PP.352-356* 1980> FEBRUARY OUR RESULTS SUPPORT THE HYPOTHESIS THAT EPOXIDATION OF THE ETHYLENIC DOUBLE BOND IN VINYL CHLORIDE YIELDS AN ULTIMATE CARCINOGENIC METABOLITE, CHLOROETHYLENE OXIDE, A HIGHLY REACTIVE COMPOUND WHICH APPEARS ALSO TO BE LARGELY RESPONSIBLE FOR THE KNOW GENETIC CHANGES CAUSED BY THE PARENT COMPOUND. DESCRIPTORS **m***rn VCMlCARCXNOGENICITYyBXS-CHLOROMETHYL ETHERjMETABOLISMjMICE jSUBCUTANEOUS HELD TERMS CHLOROETHYLENE OXIDEi IARCl REVIEW YEAR 1990 Itaa 337 ACCESSION NUMBER 593 FILE LOCATION GEN DOCUMENT TYPE RESEARCH LAB REPORT TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT HEPATIC HACROMOLECULAR BINDING FOLLOWING EXPOSURE TO VINYL CHLORIDE HATANABE PGDON CHEMICAL C0>2EMPEL JA,SAHE*PEGG 0G,SAHE>GEHRING PJ,SAME DON CHEMICAL CO,TOXICOLOGY RESEARCH LAB > 1977, APRIL 5 THE COVALENT BINDING TO HEPATIC HACROMOLECULES HAS RELATED TO THE AMOUNT OF VC METABOLIZED. AT EXPOSURES GREATER THAN 50 PPM, THE AMOUNT OF 14C BOUND TO HACROMOLECULES IN THE LIVER CORRELATES NITH INDUCTION OF HEPATIC ANGIOSARCOMA. THERE HAS NO PREFERENTIAL BINDING OF RADIOACTIVITY TO EITHER DNA OR RNA IN THE LIVER. HEPATIC GLUTATHIOFC CONTENT HAS SIGNIFICANTLY DEPRESSED ONLY AT EXPOSURE CONCENTRATIONS GREATER THAN 100 Pm. DESCRIPTORS **r VCMjDNA HELD TERMS COVALENT BINDINGjALKYLATIONjMACROMOLECULARjRNAj REVIEW YEAR 1990 Item 338 ACCESSION NUTOER 592 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT LACK OF MUTAGENIC EFFECT OF VINYL CHLORIDE MONOMER IN THE HAtflALIAN SPOT TEST AUTHOR/AFFILIATION PETER S,NONElUNGVARY G,N0NE ORIGIN NONE,VOL 77 PP.193-196* DATE 1980 DESCRIPTORS > VCM*IN VIVO J MUTAGENICITY HELD TERMS MAIHALIAN SPOT TEST* MUTATION RESEARCH REVIEN YEAR 1995 Itea 339 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN 591 GEN JOURNAL DNA ALKYLATION BY VINYL CHLORIDE METABOLITES: ETHENO DERIVATIVES OR 7-ALKYLATION OF GUANINE? LAIB RJ,NONE*GHIhMER LM,SAME*BOLTHM,SAME * NONE,VOL 37 PP.219-231* 20867111 Bp&2030 data search on ven for creig alpjt Order nuibar 901119-133245-NIZ -001-001 page 111 set 3 with 363 of 363 itens DATE ABSTRACT DESCRIPTORS HELO TERMS REVIEW YEAR 1901 IT IS CONCLUDED THAT THE COMPOUND DESCRIBED BY THESE AUTHORS, 7-N-( 2-OXOETHYL)GUANINE IS IN FACT THE MAJOR PRODUCT OF BASE ALKYLATION IN DNA AFTER EXPOSURE TO VINYL CHLORIDE. VCMlDNAlINHALATIGN|RATS}LIVER 7-N-( 2-OXOETHYL )QUANINE ALKYLATION I UNIV OF MAINZ (GERMANY) tCHEM. BIOL. INTERACTIONS! 1990 Itea 340 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS *! HELD TERMS REVIEW YEAR 590 GEN JOURNAL ROLES OF 2-HALOETHYLENE OXIDES AND 2-HALDACETALDEHYDES DERIVED FROM VINYL BROMIDE AND VINYL CHLORIDE IN IRREVERSIBLE BINDING TO PROTEIN AND DNA GUENGERICH FP,NONE|MASON PS,SAMEjSTOTT NT,DOW CHEMICAL COJFOX TR, SAMElHATANABE PG,SAME> CANCER RESEARCH,VOL 41 PP.4391-4398! 1981, NOVEMBER VCMlDNA )CHLOROACETALDEHYDE IRREVERSIBLE BINDINGICOVALENT BINOINGiCHLOROETHYLENE OXIDE! BROMOACETALDEHYDE! VANDERBILT UNIV! 1990 Iten 341 ACCESSION NUTBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS mhhhn HELD TERMS REVIEH YEAR 589 GEN JOURNAL MUTAGENICITY IN VITRO AND POTENTIAL CARCINOGENICITY OF CHLORINATED ETHYLENES AS A FUNCTION OF METABOLIC OXIRATC FORMATION GREIH H,NONE)BONSE G.NONE)RADNAN Z.NONEjREICHERT D.NONEjHENSCHLER 0,NONE! NONE,VOL 24 PP.2012-2017! 1975, JULY VCMjTETRACHLOROETHYLENEiTRICHLOROETHYLENE jETHYLENE DICHLORIDEiMUTAGENICITY1 IN VZTROlOXIRANE EPOXIDESjCHLORINATED ETHYLENESlCHLORINATED HYDROCARBONS!BIOCHEHICAL PHARMACOLOGY 1990 Item 342 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS *hhhh HELD TERMS 588 GEN JOURNAL REACTIVE METABOLITES AND CARCINOGENICITY OF HALOGENATED ETHYLENES BOLT HM,N0NE!LA1B RJ.NONEjFILSER JG.NONE! NONE,VOL 31 NO.l PP.1-4! 1982 COVALENT BINDING.METABOLISM AND MUTAGENICITY OF VCM,VINYL FLUORIDE,VINYL IDENE FLUORIDE, VINYLIDENE CHLORIDE,EDC,TRICHLOROETHYLENE, PERCHLOROETHYLENE,VINYL BROMIDE. VCMlVINYLIDENE CHLORIDE!ETHYLEIC DICHLORIDE!TRICHLOROETHYLENE IPERCHLOROETHYLENEiMUTAQENICITY! METABOLISM COVALENT BINDING! VINYL FLUORIDE!VINYLIDENE FLUORIDElEDCiVINYL BROMIDE! TCE(BIOCHEMICAL PHARMACOLOGY! 20867112 BFG 52031 data saarch on vcn -for craig algut Ordar manbar 901U9-133245-MIZ -001-001 paga 112 sot 3 with 363 of 363 itana REVIEH YEAR 1990 Itarn 343 ACCESSION HUNGER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEH YEAR 567 GEN RESEARCH LAB REPORT LIFE-SPAN ORAL TOXICITY STUDY OF VINYL CHLORIDE IN RATS FERON VJ.NONEjHENDRIKSEN CFH,NONE}SPEEK AJ*NONE}TIL HP.NONEiSPIT BJ, NONE} NONE(REPORT NO.R-5786} 1976, OCTOBER THE CARCINOGENICITY OF VCM (IN PVC ANO BY INTUBATION HAS STUDIED. A VARIETY OF NEOPLASTIC AND NON-NEOPLASTIC VCM-RELATED LIVER LESIONS HERE FOUND IN EACH OF THE TEST GROUPS. HEPATIC ANGIOSARCOMAS OCCURRED AT LEVELS OF 5.0 MG/KG AND HIGHER. HEPATOCELLULAR TUMOURS (NEOPLASTIC NODULES AND CARCINOMAS) HERE FOUND IN ALL DOSE-GROUPS. THEIR INCIDENCE HAS HIGH IN BOTH SEXES OF THE 14.1 MG/KG GROUP AND IN FEMALES OF THE 1.7 AND 5.0 MG/KG GROUPS* LON IN MALES OF THE 5.0 MG/KG GROUP* ANO MARGINAL IN MALES OF THE 1.7 MG/KG GROUP. PULMONARY ANGIOSARCOMAS (MAINLY METASTASES) ANO A FEN EXTRAHEPATIC INFRA- ABDOMINAL ANGIOSARCOMAS HERE OBSERVED AT LEVELS OF 5.0 MG/KG AND HIGHER. A FEH ZYIOAL GLAND TUMOURS OCCURREO AT THE 5.0 AND 300 MG/KG LEVELS. THERE HAS SOME INDICATION THAT VCM HAY ENHANCE THE DEVELOPMENT OF BOTH INTRA-ABDOMINAL MESOTHELIOMAS AND ADENOCARCINOMAS OF THE MAMMARY GLANDS. THE TUMOUR RESPONSE OF THE LIVER OF THE RAT TO ORAL INTAKE OF VCM SEEMS TO SHIFT FROM ALMOST EXCLUSIVELY ANGIOSARCOMA AT VERY HIGH LEVELS TO EXCLUSIVELY HEPATOCELLULAR TUMOURS AT LOH LEVELS. VCM(RATS(CHRONIC (CARCINOGENICITY }ANGIOSARCOMA}ADENQMA}ZYttAL GLAND (MAIMARY GLAND (MESOTHELIOMA} TUMORS CENTRAL INSTITUTE FOR NUTRITION AND FOOO RESEARCH} 1995 Itan 344 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEH YEAR 566 GEN JOURNAL VINYL CHLORIDE: AN EXAMPLE FOR EVALUATING MUTAGENIC EFFECTS IN MAIMALS IN VIVO AFTER EXOPSURE TO INHALATION DASLER A>N0NE(ROHRBORN G.NOWE} NONE,VOL 45 PP.1-7} 1960 AS PART OF A PROGRAt-tC OF INVESTIGATIONS ON THE MUTAGENIC EFFECTS IN MAFtlALS IN VIVO AFTER INHALATION OF ENVIRONMENTAL CHEMICALS* THE EFFECTS OF THE INDUSTRIAL COMPOUND VINYL CHLORIDE I VC) HAS ANALYSED. CHINESE HAMSTERS HERE EXPOSED TO 1.252*2.52 OR 52IV/V) VC IN AIR FOR 6*12 OR 24 H. BONE MARROH CHROMOSOMES HERE ANALYSE0 FOR INDUCED CHROMOSOME ABERRATIONS ANO SISTER-CHROMATID-EXCHANGES (SCES) 26 HR AFTER BEGINNING OF EXPOSURE. THE FREQUENCY OF VC- INDUCED CHROMOSOME ABERRATIONS ANO SCES BOTH OEPENO ON DOSE AND LENGTH OF EXPOSURE. THE HIGHEST MEASURED EFFECTS MERE 33.25 SCES/CELL AFTER EXPOSURE TO 2.52 VC FOR 24 H ANO 25.72 METAPHASES HITH ABERRATIONS* MHEN EXPOSED TO 52 VC FOR 24 H. VCM(MUTAGENICITY}BONE HARROW\CHROMOSOMAL ABERRATION(HAMSTERS)INHALATION SCE(SISTER CHROMATID EXCHANGE(ARCH TOXICOL} 1995 2086-7113 BFG52032 data saarch on vc for eraig al(^it Ordar nunfaer 901119-133245-WIZ -001-001 paga 113 sat 3 with 363 of 363 itams Itam 345 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN ATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 584 GEN JOURNAL REACTIONS OF VINYL CHLORIDE WITH RNA ANO DMA OF VARIOUS MOUSE TISSUES IN VIVO BERGMAN K.NQNE} NONE,VOL 49 PP.117-1291 1982 THE AUTHORS REPORT THE IRREVERSIBLE BINDING OF VCM KITH THE RNA AND DNA OF SEVERAL TISSUES. VCM(DNA(M1CE RNA(ALKYLATION}IRREVERSIBLE BINDING}UNIV OF UPPSALA (SWEDEN)} ARCH TOXICOL} 1995 Item 346 ACCESSION NUMBER 583 FILE LOCATION GEN DOCUMENT TYPE TRADE ASSOCIATION REPORT TITLE OR SUBJECT FINAL REPORT OF AUDIT TASK GROUP ON LIFETIME INHALATION STUDY ON VINYL CHLORIDE AT INDUSTRIAL BIO-TEST LABS. INC. AUTHOR/AFFILIATION NONE .NONE I ORIGIN CMA DATE 1978 DESCRIPTORS Hawaii VCM)ItfttALATZON}RATS}MICE(HAMSTERS(CARCINOGENICITY (CHRONIC HELD TERMS AUDIT} REVIEW YEAR 1990 Item 347 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS wwwwaww HELD TERMS REVIEW YEAR 582 GEN RESEARCH LAB REPORT VINYL CHLORIDE PATHOLOGY REPORT NONE .NONE} NONE.FOR MCA} 1979. JANUARY 9 AUDIT PATHOLOGY REPORT OF LONG-TERM INHALATION STUDY OF VCM AT IBT. VCM)INHALATION}RATS(MICE(HAMSTERS(CARCINOGENICITY(CHRONIC PATHOLOGY(EXPERIMENTAL PATHOLOGY LABS} 1990 Item 348 ACCESSION NUTBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT 581 GEN TOXICITY STUDY CHRONIC VAPOR INHALATION TOXICITY STUDY WITH VINYL CHLORIDE (ETHYLENE DERIVED) IN ALBINO RATS, ALBINO MICE ANO GOLDEN HAMSTERS-- 23-MONTH STATUS SUtttARY TO MCA 208S7114 BK552033 data anarch on ve* for craig algut Order maifcar 901119-133245-HIZ -001-001 page 114 sat 3 with 363 of 363 item AUTHOR/AFFILIATION ORIGIN NONE,NONE INDUSTRIAL BIO-TEST LABS.ZBT NO. 663-03222( DATE ABSTRACT 1975, SEPTEMBER 23 THIS 23-MONTH STATUS REPORT (9/10/73-9/10/74) IS THE LAST REPORT RECEIVEO FROM IBT. NO FINAL REPORT NAS EVER PROVIDED. SEE EXPERIMENTAL PATHOLOGY LABS,BOB NEST ASSOCIATES, AND AUOIT GROUP REPORTS. DESCRIPTORS mmim VCM(INHALATION(CARCINOGENICITY (CHRONIC (RATS(MICE(HAMSTERS REVIEN YEAR 1990 Item 349 ACCESSION NUMBER 560 FILE LOCATION GEN DOCUMENT TYPE TOXICITY DATA TITLE OR SUBJECT CHRONIC VAPOR INHALATION TOXICITY STUDY KITH VINYL CHLORIDE AUTHOR/AFFILIATION NONE .NONE ( ORIGIN INDUSTRIAL BIO-TEST LABS,FOR CMA( DATE 1973, FEBRUARY ABSTRACT PROTOCOL FOR LONG-TERM INHALATION STUDY HITH VINYL CHLORIDE SPONSORED BY CMA (MCA) AT INDUSTRIAL BIO-TEST LABS. DESCRIPTORS WMMmtM VCN \ INHALATION (CARCINOGENICITY (CHRONIC (RATS(MICE (HAMSTERS REVIEH YEAR 1990 Itea 350 ACCESSION NUtBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS jhhhhh REVIEH YEAR Item 351 579 GEN CORRESPONDENCE PROTOCOL AMENDMENTS AND COTtlUNICATION FOR THE VCH LONG-TERM INHALATION STUDY NONE.NONE( INDUSTRIAL BIO-TEST LABS,FOR CMA( 1973, TO 1976 PROTOCOL AMENDMENTS AND COPMUNICATIONS REGARDING THE LONG-TERM INHALATION STUOY HITH VINYL CHLORIDE SPONSORED BY CMA(HCA) AND CONDUCTED AT INDUSTRIAL BIO-TEST LABORATORIES. ZNHALATION(CARCINOGENICTY|CHRONIC(RAT5(M2CE (HAMSTERS (VCH 1990 ACCESSION NUFBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** HELD TERMS REVIEH YEAR 578 GEN PUBLICATION VINYL HALIDES CARCINOGENICITY NONE .NONE ( NIOSH,AND OSHA CURRENT INTELLIGENCE BULLETIN N0.28i 1976, SEPTEMBER 21 VINYL CHLORIDE(VINYLIDENE CHLORIDE(HUMAN} ANIMAL CARCINOGEN( CARCINOGENICITY (MUTAGENICITY * REPRODUCTION(EFFECTS VINYL BROMIDE( 1990 20867115 BFG 52034 data aaarch on vcai for craifl el^Jt Order meifcer 901U9-133245-HIZ -001-001 page 115 tat 3 with 363 of 363 item Itan 352 ACCESSION NUFBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTH0R/AFFILIATI0N ORIGIN OATE ABSTRACT DESCRIPTORS HELD TERMS COW1ENTS REVIEW YEAR 540 GEN JOURNAL CARDIOVASCULAR DISEASE AND ENVIROMENTAL EXPOSURE ROSEM1AN K0,N0NE) NONE,VOL 38 PP.85-97) 1979 THIS PAPER REVIEWS THE POSSIBLE ASSOCIATION BETWEEN CARDIOVASCULAR DISEASE AND OCCUPATIONAL AND ENVIRONMENTAL AGENTS. THE EFFECTS OF CARBON MONOXIDE,FIBROGENIC DUSTS, CARBON DISULPHIDE,HEAVY METALS, NOSIE,RADIATION,HEAT,COLD,SOLVENTS AND FLUOROCARBONS ARE DISCUSSED. NOISERADIATION,HEAT, COLD,SOLVENTS AND FLUOROCARBONS ARE DISCUSSEO.NENOIRECTIONS FOR INVESTIGATION ARE SUGGESTED. HEART)CARBON HONOXIDEiDUST(CARBON DISULFIDE(NITRArES)ANTIMONY)CADMIUM> LEAD(COBALT)MERCURY(00161) VINYL CHLORIDE)NOISE(HYPERTENSION)METHYLENE CHLORIDE) RADIATIONIFLUOROCARBONS(CIGARETTE SMOKE ATHEROSCLEROSIS)HYPOCALCAEHIA)ARRHYTHMIA(POLONIUM 210(ELECTROMAGNETIC RADIATIONSLEAD 210( CARDIOVASCULAR DISEASE(GLYCERYL TRINITRATE) ETHYLENE GLYCOL DINITRATE)EXPLOSIVES)CARDIOMYOPATHY) MOUNT SINAI SCHOOL OF MEDICINE)BRITXSH J OF INDUSTRIAL MEDICINE) BLHIB4) GOOD GENERAL ARTICLE ON POSSIBLE ENVIROM-tENTAL CAUSES OF HEART DISEASE KITH MANY REFERENCES CITED. 1969 Item 353 ACCESSION MUMMER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN OATE ABSTRACT DESCRIPTORS ***** REVIEW YEAR 470 GEN REPORT ETHENE, CHLORO, (CASS 75-01-4): BF6 TSCA INVENTORY SUBMISSION, FORMS A12797346, CALVERT CITY. NONE,NONE) BFG-CHEHICAL TO EPA) 1976 TSCA INVENTORY SUBMISSION OF VINYL CHLORIDE. DOCUMENT IN CHEMICAL GROUP ENVIRON AFFAIRS DEPT FILES. CAS.NO.75-01-4)TSCA INVENTORY)VCH 1990 I ten 354 ACCESSION NUTOER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGZN DATE DESCRIPTORS ***** HELD TERMS REV1EH YEAR 448 GEN BIBLIOGRAPHY VINYL CHLORIDE AND POLYVINYL CHLORIDE: TOXICOLOGY (1978-1983) - CITATIONS FROM THE LIFE SCIENCES COLLECTION DATA BASE NONE,NONE) NONE,PB84-855618) 1984 VCM(PVC|EPIDEMIOLOGY)CANCER(BIRTH DEFECTS(MUTAGENICITY(REPRODUCTION( METABOLISM(TOXICITY DATA NTIS 1990 20867116 data search on vcm for craig alpit Order nui^er 901119-X33245-NIZ -001-001 page 116 aat 3 with 363 of 363 iiaaa 20867117 BFG52036 Itea 355 ACCESSION NUt-BER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTH0R/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS awawa HELD TERMS REVIEH YEAR 386 GEN GOVERNMENT CORR SAFETY OF PLASTIC PIPES FOR USE IN POTABLE HATER DISTRIBUTION HANSON HF.EPA) EPA,TO BFfi-CHEKICAL% 1982 EPA POSITION STATEMENT ON PLASTIC PIPE. EPAPVC jVINYL CHLORIDEiMXGRATION PLASTIC PIPE(POTABLE MATER)LEACHING} 1966 Itaa 356 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN OATE ABSTRACT DESCRIPTORS HELD TERMS REVIEH YEAR 367 GEN PAPER USE OF METAL AND PLASTIC PIPES IN HATER SUPPLY DISTRIBUTION SYSTEMS LASSQVASKY P,EPA)KHAN T.SAME) EPA I9ai EPA POSITION PAPER ON PLASTIC PIPE AND THE OCCURRENCE OF DEHP (PLASTICIZER). ALSO DISCUSSED DISCONTINUATION OF LEAD PIPE DUE TO HEAVY METAL PROBLEMS. EPA)DEHP)VINYL CHLORIDE(PVC PLASTIC PIPE)POTABLE HATERlMETAL PIPE)LEACHING) 1986 Itaa 357 ACCESSION NUMBER 379 FILE LOCATION GEN DOCUMENT TYPE TECHNICAL TITLE OR SUBJECT AUTHOR/AFFILIATION HAZARDS EVALUATION A RISK CONTROL SERVICES OATA GUIDES NONE .NONE l ORIGIN NONE.BULLETINS HE-145-164) DATE 1964. MARCH ABSTRACT DETAILED FLAItlABILITY DIAGRAMS ON VARIOUS CHEMICALS. DESCRIPTORS ** VINYL CHLORIDE >ACROLEIN(BUTADIENEiDIOXANE(NAPHTHALENE ) ANILINE HELD TERMS ACETAL)ALLYL ALCOHOL)ISOAMYL ACETATElAMYL ALCOHOLiBLTTYL FORMATE) DIETHYLAMINE(ETHYL PROPIONATE) PENTENEjCYMENEjETHYLENE CHLOROHYDRIN)CHLOROBENZENE>METHYL BUTYL KETONE>METHYL PROPIONATE ) FLAMMABILITY) HERCULES XNOBUTYL CHLORIDE) REVIEH YEAR 2059 Itaa 356 ACCESSION NUTBER FILE LOCATION 307 GEN data search on vea for craifl ljfii Order ninfcer 901119-133265-HIZ -001-001 page 117 eat 3 with 363 of 563 itaaa DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEH YEAR RESEARCH LAB REPORT LITERATURE REVIEH OF THE POTENTIAL HAZARDS TO HUMAN HEALTH OF USING PVC AND CPVC PIPE FOR POTABLE HATER DISTRIBUTION NONE,NONE> SOUTHERN RESEARCH INSTITUTE ,S0RI-EAS-B3-185> 1983, FEBRUARY A LITERATURE REVIEH OF POTENTIAL HEALTH HAZARDS OF PVC AND CPVC PIPE FOR POTABLE HATER USE. THIS IS NOT TERRIBLY HELL DONE. IT HAS SUBMITTED TO J OF AFRICAN HATER WORKS ASSOC (R HILGING, IT HAS SUBMITTED TO J OF AMERICAN HATER WORKS ASSOC I R.HILGING, +REVIEHER). PUBLICATION STATUS IS UMOHN. PVC (CPVC(ACUTE(EFFECTS(SUBCHRONIC(SOLVENTSjMIGRATIONiFETAL TOXICITY BENZENE(ACRYLONITRILE ( TOLUENE(MUTAGENIC(TERATOGENIC(CARCINOGENICITY ( VINYL CHLORIDE(CHLOROFORM(TETRACHLOROETHYLENEl TRICHLOROETHYLENE* DICHLOROETHANE(CARBON TETRACHLORIDE(TRICHLOROETHANE(STYRENE( METHYL METHACRYLATE(DEHP(THF(MEK(CHLORINE(HYDROGEN CHLORIDE( ORGANOTINS(TITANIUM DIOXIDE CEHENTSiMETHYL STYRENE(LEACHING(PVC PIPE(PLASTIC PIPE( 1986 I ten 359 ACCESSION NUtBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEH YEAR 293 GEN PUBLICATION HEALTH HAZARD EVALUATION/TOXICITY DETERMINATION REPORT: GATES RUBBER COMPANY GUNTER BJ>NIOSH(LUCAS JB,NIOSH( HIOSH,REPORT NO. H.H.E. 76-6l-232( 1975, NOVEMBER A PLANT MANUFACTURING EXTRUDED HOSE, PRINCIPALLY FROM THE EXTRUSION OF POLYVINYL CHLORIDE, HAS INVESTIGATED BY NIOSH TO EVALUATE EMPLOYEE EXPOSURES TO CYCLOHEXANONE, TDI,TRICHLOROETHYLENE, ESTANE R THERMO- PLASTIC POLYURETHANE, METHYLENE CHLORIDE,NIGROSINE,DI-2-ETHYL HEXYL PHTHALATE IDOP OIL), DUST,ANO VINYL CHLORIDE. IT HAS DETERMINED THAT A POTENTIAL HEALTH HAZARD MAY EXIST FROM EXPOSURE TO CYCLOHEXANONE AND THAT SEVERAL CASES OF PRIMARY IRRITANT OERMATITIS HAD OCCURRED FOLLOWING REPEATED EXPOSURE TO SOLVENTS. ALTHOUGH ONLY ONE OF 38 VINYL CHLORIDE SAMPLES NAS FOUND TO EXCEED THE FEDERAL STANDARD ACTION LEVEL, IT HAS RECOHiENDED THAT AIRBORNE CONCENTRATIONS BE REDUCED TO LEVELS NOT DETECTED BY THE RECOBENDED ANALYTICAL TECHNIQUES. PVC(CYCLOHEXANONE(TOLUENE DIISOCYANATE(TRICHLOROETHYLENE! PLASTICS(METHYLENE CHLORIDE(DEHP(VINYL CHLORIDE(DERMATITIS(PATCH TEST(EXTRUSION(ESTANES( PERSONNEL MONITORING(NIGROSINEl 1992 lien 360 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS 205 GEN JOURNAL VINYL CHLORIDE OZSORDER WALKER AE,NQNE( NONE,VOL 105 SUPPL.2119> 1981, BRIEF REVIEW OF MEDICAL AM) EPIDEMIOLOGIC FINDINGS RELATED TO VINYL CHLORIDE IN PVC MANUFACTURE. COINAGE OF TERM VINYL CHLORIDE OISORDER. VCM(ACROOSTEOLYSIS(ANGIOSARCOMA(THROMBOCYTOPENIA(LUNGS( 20867118 BFG5203'7 11 data **rch on vea for craig el(pjt Order nurrfr 901119-133245-HIZ -001-001 page 11S ast 3 with 565 of 563 item ROYAL HOSPITAL ENGLAND)BR1TISH J OF DERMATOLOGY*PVC POWDER* CHLORETHYLENE EPOXIDEjRAYNAUD'S SYNDROMESCLER00ERMA*HEPAT0MEGALY* SPLENOMEGALY* Item 561 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION 61 GEN JOURNAL THE EFFECT OF AGE AND EXPOSURE DURATION ON CANCER INDUCTION BY A KNOWN CARCINOGEN IN RATS, NICE, AND HAMSTERS DREW RT,NATIONAL INSTITUTE OF ENVIROttCNTAL HEALTH SCIENCESBOORMAN GA, SAMEjHASEMAN JK,SAME|HC COWELL EE,SAMEjBUSEY )91,SAMEHOORE JA, SAME* ORIGIN TOXICOLOGY AND APPLIED PHARMACOLOGY VOL 68 NO 1 PP.120-130) OATE ABSTRACT 1985, MARCH 30 AT THE ENO OF THE STUDY THE INCIDENCE OF VC-INDUCED NEOPLASMS MAS COMPARED IN EACH OF THE GROUPS TO ASSESS THE EFFECTS OF DURATION OF EXPOSURE AND AGE AT THE START OF EXPOSURE ON CARCINOGENICITY OF VC. IN RATS, NITH EARLY INITIAL EXPOSURE, HEMANGXOSARCOMAS, HEPATOCELLULAR CARCINOMAS, ANO MAFPIARY GLAND CARCINOMAS OCCURRED NITH INCREASING INCIDENCE HITH LONGER EXPOSURE DURATION. RATS HELD FOR 6 MONTHS BEFORE EXPOSURE DEVELOPED VC-RELATED NEOPLASMS, WHILE RATS HELD 12 MONTHS BEFORE THE START OF EXPOSURE FAILED TO SHOW A SIGNIFICANTLY INCREASED INCIDENCE OF THESE NEOPLASMS. IN HAMSTERS HEMANGIOSARCONAS, HMtIARY GLAND CARCINOMAS,GASTRIC ADENOCARCINOMAS, AND SKIN CARCINOMAS RESULTED FROM VC EXPOSURE. THE HIGHEST INCIDENCE OF MALIGNANT NEOPLASMS OCCURRED IN HAMSTERS EXPOSED FOR THE FIRST 12 MONTHS, WHEREAS EXPOSURE BEGUN AFTER 12 MONTHS OF AGE DID NOT CAUSE NEOPLASMS. IN BOTH STRAINS OF MICE, VC EXPOSURE DURING THE FIRST 6 MONTHS OF THE EXPERIMENT INDUCED A HIGH INCIDENCE OF HEMANGIOSARCOMAS AND MAFHARY GLAM) CARCINOMAS. SWISS NICE ALSO DEVELOPED LUNG CARCINOMAS AFTER ONLY 6 MONTHS OF EXPOSURE. IN ALL THREE RODENT SPECIES AN INITIAL 12 MONTH EXPOSURE TO VC HAS ADEQUATE TO DETECT ITS CARCINOGENIC POTENTIAL, BUT THE SHORTENED SURVIVAL OF VC EXPOSED MICE AND HAMSTERS PRECLUDED A MEANINGFUL COMPARISON HITH LONGER PERIDOS OF EXPOSURE. EXPOSURES HERE HOST EFFECTIVE WHEN STARTED EARLY IN LIFE. DESCRIPTORS * AGE* VINYL CHLORIDE*HAMSTERS*MICE*RATS*NEOPLASMS)HEMANGIOSARCOMAl MAMMARY GLAND*TUMOR) ADENOCARCINOMA*STOMACH*SKIN* LUNG * FIBROADENOMA*LIVER * Itan 362 ACCESSION MJWEft FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AITTHOR/AFFILIATZON ORIGIN DATE ABSTRACT DESCRIPTORS 59 GEN JOURNAL EVALUATION OF THE ASSOCIATION BETWEEN BIRTH DEFECTS AND EXPOSURE TO AfBIENT VINYL CHLORIDE THERIAULT G, LAVAL UNIV*ITURRA H,SAME>GINGRAS S,SAME> TERATOLOGY,VOL 27 PP.359-370| 1983, CIRCA BIRTH DEFECTS INCIDENCE FOR INFANTS DORN TO RESIDENTS OF SHANINIGAN,CANADA IN 1966-1979 MERE SIGNIFICANTLY HIGHER THAN IN THREE COMPARISON COCtUNITIES. SINCE THERE HAS BEEN A VINYL CHLORIDE POLYMERIZATION PLANT IN THIS TOWN SINCE 1943 FROM WHICH TEN CASES OF ANGIOSARCOMA OF THE LIVER HAVE BEEN IDENTIFIED, THIS STUDY EXPLORES THE POSSIBLE ASSOCIATION BETWEEN EXPOSURE TO VINYL CHLORIDE MONOMER 1VCM) IN AH&IENT AIR AND THE OCCURRENCE OF BIRTH DEFECTS IN THE COFMJNITY. BIRTH DEFECTS *VCM*ANGIOSARCCHA| LIVER *POLYMERIZATION* HYPOSPADIAS*CATARACT*DOWNS SYNDROME* EPILEPSY)MENTAL DISORDERS* PSYCHOSIS*RUBELLA)PREGNANCYCNS>SIIAHINIGAN> 20867119 BFG52038 data search on veto for creig algut Order rxefcer 901119-13324S-HIZ -001-001 page 119 set 3 with 363 of 363 iten 20867120 BFG52039 Iten 363 ACCESSION MOWER S7 FILE LOCAriON GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT CONTROL OF EXPOSURE TO POLYVINYL CHLORIDE DUST AUTHOR/AFFILIATION NONE,NONE) ORIGIN HEALTH AM) SAFETY EXECUTIVE .GUIDANCE NOT EH 31) DATE 1982. HAY ABSTRACT THE HEALTH AND SAFETY COMIISSION'S ADVISORY COMMITTEE ON TOXIC SUBSTANCES HAS RECOMMENDED THAT. IN LINE KITH THE COMMISSION'S GENERAL POLICY: EXPOSURE TO PVC DUST SHOULD BE KEPT AS LOM AS IS REASONABLY PRACTICABLE) IN ANY CASE EXPOSURE SHOULD NOT EXCEED 10 HG/M3 FOR TOTAL PVC DUST IN AIR AND 5 MG/M3 FOR RESPIRABLE PVC DUST IN AIR. THE EFFECTS OF EXPOSURE TO PVC DUST ARE REFERRED TO IN PARAGRAPH 9 ANO ADVICE IS GIVEN ON ASSESSMENT AND CONTROL IN PARAGRAPHS 10 TO 13. METHODS OF SAMPLING AND MEASUREMENT ARE DESCRIBED IN PARAGRAPHS 14.15 AND THE APPENDIX. DESCRIPTORS W*>hh*w PVC DUST)AIR) STABILIZERSjPLASTICIZERS)ANTIOXIDANTS)VINYL CHLORIDE MONOMER)AIR SAMPLING)THA) RESPIRABLE DUST)TQTAL DUST)DUST SAMPLING)