Document Dn8KDkk0on7N7o346ZEdqJoO

Acute L e ~ b e m i ain Ttvo Cenentinns Following Chronic Exposure to Benzene' Abttrucr. TWOCYU of zcutc ku'naemii, one Iyri-phoS!asti; and Key f t b r ~ ' ~ the other mjcloblastic. fallowing c!i:r?nic :xposurc t3 tcnz::t io .\cu:e ! e u k ; t n i a two relatives, a man and his pat:m.n~t ucc!c. arc pruen:cd. TIC A::iaic&ial faston possibly s i p i f i u a t rele of gcnitic prcoirpoiirion i s d k d s s t d . I t Fxi1iliiii1c-xur ~ c .cf was ccnctcc?:d that sone perc:ii fa-ton \+erer r i ~ 3 e bdy cl..:ar.ic exposure to 5cn::nc in t b s patiears. ? 1 $ +T ~ incdividurtt suji:?tibi!It). 113: 5:tn conjilercd ai:< of :!le n 3 i n fzcwrs 2 in the incidenct of chronic benzecc poisoning [ B R O ~ W S C .19651. Tkcr: ?re several studies in favcur of a g r t x vari3tian in indisidzd jus;:ptibi!it;r .d [REJSEKand Reiskova, 1955; S.A%ILAH19T5I5.; Aicsov el cl.. 19711. Tk csusc orihir variation is notcornpl.tely understood. Aixordin: to BROW:',SG9 [I9651'the most probab!~expiination lies in inna:t diffcrtcces in thzpotrtcy -4 4of diife:ent individusis to carry out the ne:abolic C::oxii~~ion'A. s early as 1922 REIFSCHSEIDE~Ru g g ~ j t c3dpossibk firr.i!y sujceptibility. \+'e cin g b t .$ -!some examples from o w series o f chronic btnztnc poisorrr;ng in support of +this assumption. Two of our thlasjaenic patiezts wits apiSiiC anazrnia dce to chronic benzene CXpOSUCe, one fatal, wert brothers [AKSOY2nd ERDEM.af 19691.Also'two patients with pancyto~eniassociated with chtoric exposureP to benzene, one fatal. were cousins (XKSOYer al., 197221. 9 -9 4 T&e association betwetn benzene exposure and leukaemia is known 4 4-[VlGLIAsf nRd SMTA, 1964; .4KSoY et of.. 19725). Recently we sttidied two patients with acute leukstmia in two p m z t i o n s following chroriic exposure to benzene; one was recorded shortly elscr*hcre [C.asor cr or., 197%;. ..8 4 .1 This study WY supported Raearch Council of 1u:kry. by a gnnt (TACIi72) from the Scicn'riEc mid Tcchnini 4-. 8 I ! 9 ..i Y 1 I I i i ,-,.>,. - . I . I KSOY, X. izd E X ~ E VS..: Sonic patterns in direrent thaiaswemic synl:onres showing the kiercpcstity of beta-rh3lusacmis gena. Ann. N.Y.Aud. Sci. 165: 13 (1969). i*ioi, M.; D~SCOLK.. ; XWGCYT..; ERDEWS.,. and DtxCc 1;G.: Haematological ef- fK:s of ck:cr.k benzene pisoning in 217 workers. Brit. J. kdustr. Ned. 28: 796 (1971). iisoy. 31.; D l u ~ c tK, .; ERDELSI.,; AYcCN,+., and DisLoL G.: Dc!aiIs of b!coJ Skaz.jrr irt 32 ;?aIiencs*::k p x y ! c f x n h asstocirlcd with lon:ierm exposure 1 3 btnZCCC. Brit. 1. izdcstr. >fed. 29: 56 (1972ah tucy. \I.;D!\coL. K.: E~ongS,., and D I ~ C LG.,:Acute !cukecia due to chroait c r m c r e to be?rzenc. A c t . J. Sled. 52: 160 (1972b). JARSLRX. -aEJ EPIE;CSP,.: Oxford survey of chiIdhood cancp:. Pros. Rep. 11. Whl. Bull. Mki5t F!!:!L tab. SCW. 23: 46 (1964). Btoou. C.E.; WAaswt, S.: GEXUD. P.S., and DIWO%DL,.K.: Chromosome abnorm a k i a in ccmiitutional apiastic anemia. Sew EngL I. Ved. 274: 3 (1366). BROW?~TWXE.: Toxicity and metaboiism of industriil so!wn:s. pp. 3-65 (Elsevier. Arrs?:iCm~ !965). G~GL= A.; CAV~CSLAAetLBXEWARD, J.: Lw leucemia benrtniques. hi..Inrt. n3t. &n: 42f (i36;). G m ,M.L: Fami!ial leukacmir. Acta haemat., B u e l 48: 93 (1972). G c ~ z .F.W.: ?x.cb!em~in 1cukerr.h e ! i c ! q y . Plenary Sasioes Siiti-\iFic Czntrib:thi1s. 1:th ::. Cczv. Iiam?ar.. SIcr,i:li !XO. pp. 4-57 (lthmann) HEW. R.; KoLrn. H.D.; Ricns, D.A.; DAHSLEG., S.; Cur. 34.P.; TISDALVS., and .YrLLu. R.W.: Leukaemia and lymphocytes in ataxia-t:tar,gi!'c=iai~.Lsncct ii: I193 (139% MACMAH~E.~aYn,d Lrw, !LA.: Prenr!aI origin of childhood leukemia: tvidcncc from t w u i Xrw Engl. J. Wed. 270: 1092 (1964). %bDr.ft&Pw.S. .; ~'OU%LL, P.c.; MEWAN,W.J.; 8 ~ m'r.D. M., and ,HGsGERFORD, D.A: C!xcrnosorne prcparrtionr of leucocyta cuIturcd from human pcriphcd blood. Exp. Cell Res. 20.- 613 (1960). R u m s t i o m . C.A.: b r a 1 poisoning: its o a ~ m n c crnd pre\ention. Nac. Saf'ety Council 1lrh Roc. Annu. Cocgr. Detroit; cited from 6 ~ 0 ~ ~ 11965s. p~. 2.49.