Document DMxX5aedZbOMEBYyranaNb435

COLLEGE OF MEDICINE. EDEN AND BETHESDA AVENUES KETTERING LABORATORY DEPARTMENT OF ENVIRONMENTAL HEALTH University of Cincinnati Cincinnati, Ohio 45219 December 28, 1973 MEMORANDUM TO: Faculty FROM: D. R. Johnson and L. I. Kleinman RE: Grant Proposal We are planning to submit a new grant to NIEHS to support the investigation of the effects of lead on the kidneys of young animals. Our primary concerns will be the following: 1) can the animal model now being used in this department to study lead-induced brain dysfunction be used to study renal dysfunction; 2) can lead produce renal tubular dysfunction other than the reported Fanconi like syndrome, for instance, altered sodium excretion, urinary concentrating ability, or response to an acid stress; 3) at what stage of intoxication are glomerular function and renal hemodynamics affected; 4) do any of the above parameters correlate with blood or kidney levels of lead; 5) does infant lead exposure result in incom plete renal maturation or dysfunction that leads to adult renal failure. This research should provide some basic -information concerning renal involvement in pediatric lead poisoning. 00 806