Document DMQqpXr8J7wxbVO0vj9D66MZM

2^45 BEV ? 79 cSPOP CSTAIUSMEDI902 E. I. d u P o n t d e N e m o u r s S C o m p a n y IN C O R PO R A T ED W il m in g t o n , D e l a w a r e 19898 POLYMER PRODUCTS DEPARTMENT EXPERIMENTAL STATION PERSONAL AND CONFIDENTIAL co: A. J. Dahl B. W. Karrh L. J. Papa Pral File I.C. - 353 - N11400 - 269 > //e 2 2 6 -/5 7 3 May 15, 1981 DR. B. RAMIREZ CR&D HASKELL LABORATORY ANALYSIS OF BLOOD SAMPLES FOR PERFLUOROOCTANOATE (Job No. 810-578; PRAL Nos. 81-01544 to 01552; Notebook Nos. E22514,E26238) As requested in your letter of 4/20/81 to L. J. Papa, the nine blood samples submitted then have been analyzed for perfluorooctanoate (Cs) Results and sample identification are given in the attached table. As noted there, the analyses were done using a gas chromatographic method specific for Cg (Lab Method Number ES-567) but results have been reported as ppm F for comparison with total organic fluorine analyses. Precision is + 10% relative standard deviation over most of the concentration range, somewhat less at the lowest values. The lower limit for quantitation is 0.007 ppm F (0.01 ppm perfluorooctanoic acid), with a detection limit of n 0.004 ppm which can be distinguished from the reagent background but not well quantitated. Please contact me (772-4440) or L. J. Papa (772-2745) if you have any questions regarding the analyses. General questions on blood sampling can be directed to J. W. Raines or L. F. Percival. Attachment jah Key Words: Perfluorooctanoic Acid Perfluorooctanoate Blood Analysis GC S. S. Stafford There's a world of things we re doing something about 000070 EXP000007 EID713821 TABLE I CONCENTRATION OF PERFLUOROOCTANOATE IN BLOOD (a) Sample PRAL No. Date Sampled 81-1544 81-1545 81-1546 81-1547 81-1548 81-1549 81-1550 81-1551 81-1552 4/20/81 4/20/81 4/20/81 4/20/81 4/20/81 4/20/81 4/20/81 4/20/81 4/20/81 P.R.No - Name GC Analysis____________________ (b Date Analyzed ICr ], ug F/r blood 4/21/81 4/21/81 4/21/81 4/21/81 4/21/81 4/21/81 4/21/81 4/21/81 4/21/81 0.030 n.d. n.d. 0.012 n.d. n.d. 0.0098 n.d. 0.0096 (a) Analysis as described in Lab Method ES-567 ("Determination of Perfluorooctanoic Acid in Blood, Gas Chromatographic Method", S. Stafford, 4/3/81), using the packed column GC analysis with perfluoro-n-octanoic acid as calibration standard. (b) Although the analysis is specifically for perfluorooctanoate (acid or salts), concentrations are given in ppm fluorine for comparison with the results of total organic fluorine analyses. (ppm F = 0.688 x ppm perfluorooctanoic acid) Estimated uncertainty is + 10% relative standard deviation. The lower limit for quantitation is 0.007 pgF/g. The detection limit is 0.004 ygF/g, but concentrations in that range cannot be well quantitated and are reported as < 0.007. None detected (n.d.) is reported for samples with [Cg] < 0.004 ppm. which cannot be distinguished from reagent background. ^ 000071 *REDACTED* EXP000008 EID713822