Document DMOJZLykdXZLprVqb9ev5qpOd

CHEMICALS INDUSTRIES INTEROFFICE / LAKE CHARLES TO Distribution, DATE April 22, 1974 FROM rR. P. LynctpAI] SU3JECT VCM Tank Car Safety Meeting A review of the rulings and company reactions to these rulings was made in Philadelphia at the 7CM tank car safety meeting. X was most impressed with the change in attitudes of most of the VC Poly people__They are doing most of the things that were impossible in February (by their words). 'T^xhe most importaut item was the souse failure. A table of results shows this:. `S'... ir ~fy - Control Group SO ppm VC*^ ; 200 ppm VC - 2500_ppmVC " _ _ : r . Mice 15/5 31/9 7/13 `8/13 Mortality (M/F) Rates 4/4 10/8 6/9 5/7 Hamsters 13/22 20/20 22/29 r 27/27 : ..?r*The VC was administered for 7 honrs/day for 5 days/week. The rodents " t~ -' Results of Autopsies Tumors - lung Angio Skin 4 22 2 6 3 4 `2 19 17 17 .3 As. may be. readily seen these results will lead to some severe restrictions . - on VC- The existing temporary standard will probably not stand. - It is hoped that 10 ppm will be tried. The mice test is equivalent to approximately 20 to 25 years for a human when the first angios were found. Moltoni is also finding tumors at low levels hut his work is not released yet. (Most of the mortalities are from eating one another because of hunger.) BFG new has approximately ten cases. Only two or three died of ahgio but the others are reasonably real. Most of them had slides of biopsies that were checked for angio. Some of the deaths are back to 1969. SL 027177 3.68DS PXO?CSED RULES (c) The Deputy Administrator. Vet have been occurrationally related. As a the level from a ceiling of 5C0 ppm to 50 erinary Services, upon request to him. result of this noi.ticatlon and after con ppm ceiling. It was expressly recognized niay approve other Identification systems sultation with the National Institute lor that this standard limiting exposures io in specific cases and under such condi Occupational safety and Health a 50 pptn level was Intended to be a ten tions as he may prescribe if he deter (NIOSH), and a joint Inspection ol the tative. interim standard, to be hi died mines that such systems provide the plant by OSHA, NIOSH, and the Ken no longer than six months, during which necessary information to allow for trace- tucky Department of Labor, a fact-llnd- time the whole question of possible sale hack of the swine to their herd of origin. Ir.g hearing on possible hazards involved exposure to VC would be reconsidered Any person who wishes to submit writ with the manufacture and use of VC more luily and In the light of more In ten data, views or arguments concerning was announced on January 30, 1974 (39 formation. especially results of experi the proposed amendment may do so by FB 3374) and heid on February 15. 1974. ments wliich were known to be under miner them with Deputy Administrator, 2. Carcinogenicity ol VC. Information way at that time. Veterinary Services, Animal and Plant produced at this hearing demonstrated 4^Additional tnjormation. On April 1^ Health Inspection Service, U.S, Depart that exposure of laboratory animals I9T4. information and data were- pre-^ ment of Agriculture. Hyattsville, Mary mostly Sprague-Dawiey rats) to VC by sented -to-*-representatives- cl. OSHA,, land 20732 before August 12. 1374. inhalation at and below the then current NIOSH and the- EPA by the Industrial Ail written submissions made pursuant OSHA standard of 500 ppm induced Blo-Tcst Laboratories. Northbrook. Illi to this notice will be made available for tumors, including angiosarcomas of the nois.- concerning results. of- animals ex-- public Inspection at the Federal Build liver. Professor Cesare Maltonl, of the - posure studies with.VC, sponsoreiLbytber: ing. 6505 Belcrest Road. Room 870, Institute di Oncoiogia, Bologna, Italy, Manufacturing Chemists -Association. Hyattsville, Maryland 20782, during reg reported on a series of experiments on (MCA! -Although only preliminary liw ular hours of business (3 ana. to 4:30 tue effect of exposure of rats, mice, and nature..these results revealed that 2 out- pun., Monday to Friday, except holidays) hamsters to VC at concentrations of of 200-mice exposed to VC concentrations in a manner convenient to the public 10,000f 6,000; 2J00; 500; 250; and 50 af SO ppm.Ior.7.hours a. day, fiverdays at- business (7 CFR 1.27<b>). ppm lor varying periods of time (TR- -weefch formpproximatety Ttmonths^deg* Comments submitted should bear a 43-63).. Some of toe experiments have TCtopeCaneiasareomaaof-thejlvep3"1"^ reference to the date and page number been concluded, and others are still on-- TheThdustridrBlo-Tcst^Iiab'data In of this issue in the Fnaxaa. Rzcsiza. going.The experimental results reported dicatc tbatrexposure-to-CVCfatt5atrppi4 Done at Washington. D.C, this 7th day of Mat 1974. PjEBsn A. Cuaioux, Acting Deputy Administrator, Veterinary Services, Animal and Plant Health Inspection Service. were that tumors have been observed In --maxwell cousUtute ausertousdsealtluhaz-* groups of animals exposed to VC at con- -ardito-employees. Also, tiW'oaestlambLJd^ centrations as low as 250 pprn. Noiumorx safeMleweL-oLcAxposure-Xoprbnmanasiean- neshe determined airthisjtlmeaanthmnyh*- es^dsedito^VgagagcbncentrattouSoJgjg cbhUmie^aaratimatter forvscienifle*dppngg&alsoappeiiyiOiatithMhtaLhiun? Qb^caUbrefc^many yeafs'.'TVedhcreforr bcssfbC'tnmnisia^rriLfas the^numberr conclude tffaETt is now necessary to pro pose to change the 50 ppm level estab (Fa Doc.74-10882 riled A--74;8:i5 am] lished in the ETS to as low a level as can tqgSOEppmf Another experiment by Pro be detected using methodologies outlined DEPARTMENT OF LABOR Occupational Safety and Health fessor Maltonl waxjenorted^underway^ in this proposal. Involving the^expw^^ta300aanimals^~- -- Administration [ 29 CFR Part 1910 3 [Docket OSH-acj VINYLiCHtORlD: whether that level of exposure produces tumors tn animals. Bata reported by TorkefeoigSOygx andSESw? (American IndintrM Hygiene Association J 22:254-- - Proposed^-Standards 361 (1961)) indicate: tbatfexpcsmeiticT' VCfgt.concentrations o^50fppiwfaneiEtr 1. Background. Vinyl chloride (chloro- cthene) Chemical Abstracts Service . ^. ' ~ Registry No. 75015, Is a synthetic chemi cal made by oxychlorination of ethylene or by hydrochlorination of acetylene. It is the parent compound of a series of themoplastic resin polymers and co polymers which are widely used for con tainers. wrapping film, electrical insula tion, pipe, conduit, and a variety of other products. Vinyl chloride has been made commercially in this country since 1939 and present production is in excess of seven billion pounds per year. Vinyl chloride (VC) is a gas at am bient temperature and pressure and is a chlorinated hydrocarbon which has moderate liver toxicity. The previous standard set a ceiling value of 5C0 parts per million (ppm) (20 CFR 1910.93, Table G-l). On January 22,1974, the Occupational Safety and Health Administration (OSHA) was informed by the National Institute for Occupational Safety and Health (NIOSH) that the B. F. Good rich Chemical Company reported that deaths of several of its employees from a rare liver cancer (angiosarcoma) may 'The employees of tbe-8. Ft' Goodrich j rhumiral riQpipany Hn died fmm nnpiP- sarcoma of the liver had on average ex posure of approximately 19-years to vinyl chloride, at unknown concentrations, and variable exposures to other volatile chemicals. (TR 93). Some employees of Union Carbide, Firestone Tire and Rub--, ber, and Goodyear were also reported in post-hearing comments to have had ex posure to vinyl chloride and to have died from angiosarcoma of the liver. Finally, autopsies of four deceased employers re vealed their liver acgtasaraoina tumors wero histologically indistinguishable from the angiosarcoma tumors observed in Professor Mailoui's experimental animals. 3ST3ierBnve^geni^Tampor^yisijCtnk^: crd>On the basis ~or~all information available at that time, and the fact that, employees were being exposed at levels around the experimentally observed ef fect level of 250 ppm, an. Emergency Temporary Standard (ETS) was promul gated on Aprii.5^2W?(3D FR 12342) ns . 29 CFR 13TV.7Zc?*nu& standard reduced FEOEBAl KKPSTtt, VOL 3?, NO. 92--FBIDAY, MAT to, 1474 SL 027178