Document DMGQJJXOK4m32Mr57Q6BEn19B

December 5, 1962 TOXICITY AND SAPB HANDLINO OP FYDRAUti A-2QQ Animal toxicity studies with this product have lndloated that the oral lethal dose (LDc0) to rats Is 10,500 milligrams per kilogram. The lethal dose when the material was applied un diluted to the unbroken skin of rabbits Is approximately 1250 milligrams per kilogram. We conolude from the above that accidental Ingestion on the part of humans Is not a particular hazard in view of the high oral lethal dose in rats. Similarly, single massive skin exposures should not be Immediately hazardous. The lethal dose obtained In skin penetration studies Is suoh, however, that prolonged and repeated skin eontaot should be avoided beeause of possible systemlo effoots. In addition, prolonged and repeated skin eontaot may lead to skin Irritation. We also feel that vapor Inhalation should be avoided when the fluid Is heated to elevated temperatures. Suoh exposure again relates to prolonged or repeated exposures rather than short term massive or acute exposures, in the oase of the latter, workmen would not voluntarily expose themselves to concentra tions that are hazardous because of Irritation of the respira tory tract. The use of Pydraul A-200 In Industrial hydraulic fluid appli cations should not present toxlolty hazards during the transfer of the fluid from original containers to the hydraulic system. Obviously, whan the fluid Is within the hydraulic system, there should be no exposure and consequently, no hazard, in the event of rupture of hydraulic lines and subsequent splashing or sprayli of the fluid on the heated surfaoes, vapors of the fluid and possible decomposition produots (depending on the temperature of the heated surface) may be irritating if inhaled to the degree that workmen will not voluntarily expose them selves to toxic concentrations. No hazardous exposure should result during the Interval required to shut down the system and obtain suitable respiratory protective devloes during repairs to the system. HONS 071305