Document DM6RKweBBVy9RMwo1aRQY8jZ5
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June 9, 2005
FER odes -icossg CuownfcieddeenrtaiallExpress
UOSPPETnvDiorcounmmeennttalCoPnrtortoelctOifofniAcegeMnaiclyCode 7407M
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Attention: Section 8(c) Submission
EPA East Building, Room 6428
Company Saritized
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`1W2a0s1hiCnogntsotni,tuDtiCon20A4v6e0n-u0e00N1W
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=
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Subiect: TSCA (e)
carbonyl sodium
Notice
_salt,
- Cyelohexenc-carboxylic acid, [(di-propenyiaming)
reaction products with _pentafluoroiodoethane-
"==
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tetrafluoroethylene telomer, ammonium salts
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Dear Section 8(e) Coordinator:
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This letter contains Confidential Business Information (CBI). CBI is bracketed { J. =
IunndaecrcothredaTnocxeicwiStuhbsEtPaAn'csesMCaorncthrol16,Ac1t9(78TSPCoAl)i,cythSetaEtPeAme'nstJounne,Sec1t9i9o1n T8S(C)AreSpeocrttiionng
d8a(t)edRJeupnoert3i,ng20G0u3id(e6,8
and Fed.
EPA'S TSCA Reg. 33129),
CSiebctaiSopnec8i(acl)tyPoClhiecmyiSctaaltsemCeonrtporaantdioGnuiwdiasnhcees
0 14
bring day
rtaontghee
aftitnednetriocnoonfdtuhceteEdnvfiorroanbmoevntealnaPmroetdecmtaitoenriAagle.nc{ y
the
results
observed
in
a
(gavage) study ofcompound ]
in the Wistar Rat unexpected effects
animalsJ. (3I/ndoase1)4edxapyosdeodsetor1a0n0g,e3f0i0ndoirng10or0a0lmtgo/xkicgi/tdy were produced on the liver in both sexes. There was no
emfofretcatlsitwyerneorevaindyenctliannicdalthseigfnosodorcognrsosusmpptaitohnolaongdy btoodyindwieciagtehtagnayintrweeartemenstimirlelaartetdo
controls. Furthermore, portion of the study.
nHoowceovmerp,ouinndthreelamtaeldecshatrnegaetsedwweirtehno3t0e0dadnudrin1g00t0hemhgekmgadto,lotghye
a1b0s0o0lumtgekga/ndd,/ortherelalitvievre
-ltiover-bwraeiinghtwseigwhetreraetlieovawtaeds
and in higher
tthhean feinmaltehse
dcoonsterdolsa.t
Hhiissttioopcayttihco)lowgiitchalsifnignldeicneglsl
included necrosis
minimal to slight and hepatocellular
ihynpfelratmrmoapthoyry(cceenltlrifloocbiul(arl)ymipnhaol-l
.
pitied
- oo
Value beyond chernistes
"teresstulgtrsoouftphsisansdtufdyu,yalNivOerELcha(nNgoesObisnersvoambeleoEffftehcethLiegvheels)t cdoousleddnaontibmaeldse,teBramsiended.onOtnhee
tfiemmealceourratsedoifdtdheeveelxopperaimmealnitg(n1a4ntdalyys)mpahnodmtaheoofctchaesiloinvaerl aoncdcusrprleenecnehoofwleyvmeprhdoumeastoatshea
background lesion pathologist deemed
at this young this finding as
life stage of the test not treatment related.
animals
(~
9
weeks
old),
the
Ciba is establish
presently a NOEL,
retesting this and to better
product in a understand the
csaeucsoendand1/4o-rdamyecrhaanngiesmfiondfitnhge
study, to observed
findings by additional investigations
* AnLiveard-dsipteicoinfailc dcloisneicgarlobuipocwhilelmibsetrtryewaitleld bweitpher3f0omrgm/ekdg/d
+
Liver microsomal `marker for hepatic
fauric acid peroxisome
p1r1o-liafenrdati1o2n.-hydroxylase
will
be
determined,
as
a
Please note that this material is currently under PMN review. {
}
A sanitized product was
copy of this letter is previously submitted
ewnictlhoseTdS. CTAheSeCcBtIionSub(sct)antdioactuimonendtoccounmternotl
for this number
SunEdHeQr-s0ig5n-e1d6a0t23436as801i-nd2i3c5a2t,eidf yboyu chuarvreenatnyTqSuCesAtio8n(sc)cornecqeuimrienmgentthsi.s suPblmeiassseionca.ll the
Respectfully, Bonita G. Reynolds Sr. Regulatory Specialist ce: Loraine Passe, US EPA
2