Document DGvd8wbKaM5kaOzJ0vMNjoLBO

94 Morris Greenberg and T. A. Lloyd Davies certificates in 35 instances. The pathological diagnoses in these 35 cases were: Carcinoma or bronchus........................... 11 Carcinoma, origin unstated .................. 10 Secondary adenocarcinoma (primary unstated) .................................................. Not mesothelioma (no other diagnosis) 4 Myelomatosis...................................... - l Transitional carcinoma of bladder .. ] Adenocarcinoma of thyroid .. .. 1 Retroperitoneal fibroma or chordoma 1 Asbestosis and tuberculosis .. .. 1 Severe anaemia secondary to peptic ulcer 1 Malignant melanoma .. ,.. .. 1 As the concordance of diagnoses between the UTCC pathology panel and other pathologists was higher than 74% and the characteristics of the two groups are so simitar for. distribution of age at death (Fig. 1), tumour site, sex (Table 2). ahd survival (Figs 2 to. 4), they can be treated as one. In this study peritoneal tumour represented 12-2% of all con* firmed mesotheliomas (Table 2). This compares with reported proportions by five authors with a range of 3-7% (of 80 cases) to 72-7% (of 22 cases) (Table 3). From Table 2 it can be seen that the distribution of c3ases between the sites was similar in the groups confirmed by UICC pathologists and by otber pathoiogists. Sex distribution Table 2 shows that the ratio of mesothelioma in men and women for both UICC and other pathologists was about 5:1, which is similar to that for all malignant neoplasms of the respiratory system (Registrar General, 1970). The sex difference in carcinoma of the bronchus in general is thought in part to be due to difference in smoking habits (Hammond, 1966) but tobacco is not known to play a role in the aetiology of mesothelioma. If it is assumed that mesothelioma is related to asbestos TABLE 2 246 `Definitc' Mesotheliomas analysed by Sex and Site or Tumour Pathologists UICC Panel.......................... Other pathologists * ah .. ' -......................... Site of tumour Pleura) Peritoneal Pleural Peritoneal Pleural Peritoneal Moles (*( ofell merethelial tumours) 96 14 (12-8%) ' tl 10 (10-9%) 177 24 (12-0%) females {*/ ofell meso* theUol tumours) 22 2 (M 17 4 (19-0)0 39 6 <13350 Total 111 16 <11*950 96 14 (12*3/0 2t6 10 (12-250 TABLE 3 -- Prevalence op Perttdneal Mesothelioma retorted by Various Authors Authors McEwenVrat. (1970) ,, .. Ashcroft and Heppicston (1970) .. Sclikoff et at. (1970) Thomson (1970).......................... Mcwhouse et ot. (1972) .. .. Present study .......................... Alt mesotheliomas 10 23 22 17 11 49 246 Peritoneal. mesotheliomas otUf {total) J (3-750 3 (13-050 16 (72-750 3 (17-650 3 (43-450 30 (61-250 30 (12-250 Comment 73 males and 7 females; 2 males described at 'both iie*` (Scotland) * Tyneside Male insulation workers (USA) Cxpe Town Females (London) t. Males from the same factory England, Wales and Scotland 1967-66. exposure it of men ami order to a*> to mesothe! Arc at deet The distrih is presentev ferenee betof patholoy pathologist' distribution carcinoma General, I1 death from (r < 0-05) `all neoptas either to It tional earn with the re lioma assoi carcinogen. Exposure tc In Table 4 i 167 (68%) asbestos ar either at w 30 Del Hec SC 20/!* 10- 7 Tee" * All < 30 7 W O T'n * Ytort no. t. Age