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AR226-1307-2
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August 5, 1996
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To: FROM:
WILLIAM J. VOGLER CRED HASKELL LAB H-1, ROOM 353 NEWARK, DE
VY.isHL.inGPTOWoENR,voMr.eDs. 2?
C-8 STUDY
Please find attached charts of data developed from reviewing medical records on 51 employees with the highest measured levels of C-8 in their blood. It would be Jogterl to expect that any disease attributable to C-8 should be found in employees with the highest levels of C-8.
Ve d1d finIdn msyeveorpailniosna,plvoeyerayslwiittthle ferveiqdueennctesloefvdaitsieonasseofdueblotoodC-t8eswtsas found.
(SGOT = 7, Alkaline Phosphatase - 10, LDH - 7) but no evidence of liver
dSitsuedaisees. verPeerhdaopnse. C-8Newa4s50thefocuanudse2 cofasetshesoef ekliedvnaetyiodniss,tasbeutannod coonnetrcoalsleedof Ctahursoem.bocyTtheopesniigan/ilfeiuckaonpceenioaf tthhaetsecoiusldunncolteabretoatmtsr.ibutable to some other
Please Tet me know how we should proceed with this study.
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-8 SUMMARY OF LAB RESULTS
LIVER ENZYMES
Level of C-8 (opm)
sor
Slight Elevation Occasional
Frequent Significant Elevation
Alkaline Phosphatase
Slight Elevation Occasional Frequent Significant Elevation
we
Slight Elevation Occasional Frequent Significant Elevation
Bilirubin
SOicgchatsiEolneavlation Frequent Significant Elevation
Exployees in Study
00 50 4s 3a
3
1
2
3
0
0
S
"
`
2
1
1
0
1
5-
1
2
0
5
0
0
<1
1
7
0
2
0
0
C
"
0 0
0
0
c 0 oo s1
5
4
3
2
0
0
[A
5
1
3
2
0
0
5
3
1
0
0
021
sn
Total
10 7 1
12 10 0
1" 0
2
0 1
5 [200
Notes:
Emmt 4 Slight Elevation: Lessthin 1X narmal Tab results. icasional: 1-3 abnormal tests
Significant: Test results greater than 1X normal.
Y8L/P2o/w9e6r:mah Doc. 023402 (Chart #1)
3
EIDI07067
8g
000007
C-8 SUMMARY OF LAB RESULTS 8LO00
Level of C-8 (ppm) 100 510 45 34
Total
Increased WBC
Occastomal (1-3) 2 2 ` 1
9
Frequent (4+)
0
2
1
1
`
Decreased WBC Occasional Frequent
0
0
0
2
2
0
0
0
2
2
Anemia - Mild 10-13 g Hgb)
Occasional
Frequent
0
1
2
2
5
0
0
1
0
1
Throsbocytopenta
1
1
8/2/% YLPower:sah
Doc. 023403 (Chart #2)
3
EID107068
3
000008
C-8 SUMMARY OF LAB RESULTS KIDNEY
Level of C-8 (ppm)
10+
s-10
-5
3-4
BN
Slight Elevation
Occasional Frequent
1
5
0
0
Significant Elevation
0
0
1
5
3
1
0
0
WRINALYSTS
~Hematuria
FOrcecqausieonntal
~Pyuria
Occasional Frequent
~Albumin
FOrcecqauseinotn.al -Casts
11
21
0
1
0
0
0
`2
1
01
30
3
2
1
0
`
4
1
Total
12 4 0
12
6 1
122 2
8DYo/LcP2.o/w%e0r2:3m4a0h4 (Chart #3)
322 g
EID107069
000009
SUMARY OF POSSIBLE DISEASE
AND/OR SIGNIFICANTLY ELEVATED LABORATORY RESULTS (MORE THAN 1X NORMAL:
c-8 Level 1) 10+ 5-10
4-5 3-4
LIVER
Yo. of
Employees 0 0 0 a
a= (1) Significant elevation bilirubin (2-3 mg/DL) on most results. Liver
enzyme test normal. No Japeris established. Most likely Gilbert's Disease. No clinical significance.
N(o2)diSaiggnnoisfiiscanetstaeblleivsahteido.n SGOT (more than 1X normal) on 2 occasions.
8L000
C-8opLmev)el
150-010
4-5 3-4
ExNop.ioyofees
00
0 n
a = Diagnosed throsbocytopenta and Teukspenta evaluated by hesotologist.
No etiology found.
.
(cont.)
z
3
EID107070
3
000010
AND/OR SIGNIFICANTLY ESLEUVMAUTREYD LOFABOPROASTSOIRBYLEREDSIUSLETASSE(HORE THAN 1X NORMAL (cont)
XIoNEY
8(ooLme)vel 150-01 ipes
EaNop.ioyoefes 21 0le
a= eDsetfaibnliitseheedv.idence of kidney disease (casts & hematurta). No diagnosis b= e(s1)tabClhirsohnefdc dailabgunsotnsuirstao.f diEasbteatbilcisnheepdhrdoipaagtnhosyisbuotfmdoisatbe1t1ekse.iy cNaouse.
(2{)agCnhorseinstcofadlibsubmaitneusr.ia.OtaHbiesttiocrynoefphrhoigphathBylomoodstsugaIrikse.ly cNaousees.tab! shed = Evidence of kidney disease - casts. No diagnosis established.
Y/L2Po/v%er:aah Doc. 023405 (Chart #4)
= 3
EID107071
2
000011