Document DGmmmBX20am85z8eVqZ6prw2N

Monsanto I |MMI lf*C Medical Department m i May 5. 1971 . lP7ICt PCB Publication TO : W. B. Papogeorge WPAPA W. R. Richards - WRICH H. S. Bergen - HBERQ R. Keller - Queeny S. Tucker - Queeny Peter Marsh - Brussells A1 Voddcn - Ruebon E. John - EJOHM P. S. Park - PPARK Sam Pickard - Washington The Bulletin of Environmental Contamination end Toxi cology which we recelvsd-EoiTey lncTu3e3 oeven articles concerning polychlorinated hlphenyla. The first one Is of Interest since it concludes that "PCB's do not plsy a significant role In the phenomena of egg-shell thinning". The seoond article on metabolism will be of Interest In relation to our current analysis of tissues from the animals being studied at Industrial Bio-Test Laboratory. Further, the summery indicates "Male rats were orally dosed with Aroclor 1254 and residues were found In ell tissues analyzed, with the greatest concentration In the fat..............Aroclor 1254 significantly Increased the size of the liver and also the percent lipid In the liver. Aroclor 1254 was found to potentiate the toxicity of cai'bon tetrachloride In the rat'1. The third article reports data from the Oulf Breeze Lab oratory which lead to the conclusion "that chronic ex posure to Aroclor 1254 Increased susceptibility of test pinfish and spot to disease, and also appeared to be toxic to these fish". The fourth article dealing wl'th microsomal enzyme activity In pregnant rabbits Indicates that Aroclor 1221 Is less active In the Induction of enzyme activity aa compared to Aroclor 1254. The fifth article indicates that one marine diatom "Cvllndrotheca closterlum absorbed and concentrated the polychlorinated biphenyl (Aroclor 12A2) 900 to 100 tlmea above the level In sea water. At .1 ppm concentration in sea water, PCB's Inhibited growth and diminished levels of RNA and chlorophyll of thlB marine diatom". The sixth article will be of particular Interest to those Involved in retention times and electron-capture detector responses of some of the individual chlorinated biphenyls. The last article again relates to analytical techniques l.e. "thin layer chromotogrsphy of polychlorinated biphenyls. Elmer P. Wheeler mons 099750 tp