Document DGOY5RdNrRX9Ywzmjn18jygOQ

Mar ch. E 7 , 1935 Dr * Lo u is P* Bosn ian Afr ica n L ife Bu ild in gs S t . Ge o r ge * 3 S t r e e t Cap o Town . De a r Dr * Bosn ian : I h a ve y o u r l e t t e r o f Fe b r u a r y 17t b w it h r egar d to the "q u a lit a t iv e in v e s t ig a t io n o f u r in e and fa e c e s \ # ith a vie w t o le a d 15. I am n o t q u it e c e r t a i n t h a t I know w h a t yo u mean o r w h a t y o u w is h . "'e i n t h i s la b o r a to r y''h a ve n ot worked w ith q u a lit a t iv e m ethods, h e n ce X am u n a b le t o s e e how . th e m ere d e t e c t io n o f le a d in b i o l o g i c a l m a t e r ia l w ould be u s e fu l . I t ha3 b e e n d em on str ated a d e q u a t e ly t h a t m in u te amounts o f le a d ar e t o b e fo u n d in p r a c t i c a lly a l l t yp e s o f b i o l o g i c a l ma t e r i a l s . The e v id e n ce w h ich we h a ve o b t a in e d on t h is s u b je ct has, been p u b lish e d in la r g e m easure in the Jo u r n a l o f i n d u s t r i a l H y gie n e - Volu m e 16 - 'la r ch 1 9 3 3 * The p r e c is e q u a n t it ie s fo u n d , t h e r e fo r e , u n d e r a v a r ie t y ox' c o n d it i ons becom e e s s e n t i a l fo r a n y t y p e . o f in t e r p r e t a t i o n . I f yo u a r e m e r e ly I n t e r e s t e d Irr t h e m ost s e n s i t i v e means o f d e t e ct in g le a d , I th in k i t Is q u it e c e r t a in th a t sp e cfcr o gr a n h ic m ethods a r e th e m ost e ffe c t i v e . I t is p o s s ib le t o d e t e c t t h e p r e s e n ce o f le a d i n a few d r o p s o f b lo o d or u r in e ,q r s p in a l f l u i d , or t is s u e s m er ely by in tr o d u cin g the m a te r ia l in q u e stio n in to the cr a t e r o f a ca r b o n e le c t r o d e and a ft e r d r y in g i t , u s in g th e sam ple i n t h e e le c t r o d e i h T;bhe e l e c t r i c a r c . The p r e s e n ce o f le a d in a few p a r t s p e r b i l l i o n o f m a t e r ia l can be d e m o n s t r a t e d i n t h i s way*. On t h e o t h e r h a n d , i f yo u a r e th in k in g o f th e a p p lica t io n o f q u a lit a t iv e t e s t s to c l i n i c a l m a t e r i a l , I ca n o n ly e x p r e s s my co m p le t e s k e p t icis m as t o th e con seq u en ces o f any r e s u lt s w h ich may be o b t a in e d * Pe r h a p s X am m is - in t e r p r e t in g y o u r i n q u i r y , and y o u r gr o u n d s fo r in t e r e s t i n t h e s u b je c t * However i f you w i l l w r it e me an d t e l l me w h a t yo u w is h t o kn ow , 1 s h a l l do ray b e s t t o g iv e yo u a n a n s w e r . Ve r y t r u ly y o u r s , RAK:i S Ro b e r t A . Ke h o e , M.D*