Document DGEVwNBG2NBvBD68GxLNxp11N

INTEROFFICE MEMORANDUM To _ A. R. Adams From 0. T. Barr cc: C. E. Blades G. J. Hantell W. M. Smith H. L. Watson Subject Date 21 August 1975 Suspected Cc clnoqens Valley Forge (Location, Organization, or Department) Valley Forg< (Location, Organic ion, or Department) I have reviewed the Federal Register of 23 dune referre< to in the attached letter from SPI for compounds or types of materials of inten t to APCI and found those listed in the attached table. There probably are othei that I missed. I really do not know what to do next. We do not generate any specific data ourselves that would be useful to report. This is worse thai a wish-list, it is a witch hunt. For example, several years ago investigators iplanted foreign material in the skin of mice, and found "tumors" at the site This included polymers, glass, sand, etc. Such are the bases for this 11 si ""Any suggestions? If fat and sugar are carcinogens, we I ve a problem. /mjv Attachment 1320) AP00026237 I sFP THE SOCIETY OF THE PLASTICS INDUSTRY, INC. 355 LEXINGTON AVENUE NEW YORK. NEW YORK 10017 212/573-0400 RECbivED AUG ao '19/:* August 11, 1975 ji.) <UA*eurr* To: From: AUG 1 9 1975 SPI Voting Representatives A. ROSS ADAMS John R. Lawrence 0+ uj*AC kyT^C Subject: NIOSH "Suspected Carcinogens" Data Survey ^f*T The attached memorandum reviews the need for action on the part of Ain ^f certain material producers to supply Information to NIOSH on certain plastics and plastics precursors to clarify any possible health hazard of these materials. If your company produces any of the chemical substances listed by NIOSH, It will be important to give this matter proper attention. If such concerns are not in your area of responsibility, please pass this material along to the proper person within your coirpany as you may be the only person In your company receiving this matterlal. Thank you. ^Juio --' JRL/IS Enc. Technical Director AP00026238 INDUSTRY REQUESTED TO COOPERATE WITH NIOSH ON CHEMICAL AGENTS "SUSPECTE CARCINOGENS" DATA SURVEY On Monday, June 23, 1975 the National Institute for Occupational Safety and Health (NIOSH) published a Notice in the Federal Register (40 Fed. Reg 26390 et sea.) requesting information on certain chemicals, AttaclTed to this Bulletin is a copy of the introductory s ection of this Notice; the complete listing of chemical referenced in the Federal Register is far too bulky for mass distribution but copies can be obtained by ordering the June 23 issue of the Federal Register, Part II from Office of Federal Register, National Archives and Records Service, Washington, D.C. 20408--Price 75 cents. What has occurred is that NIOSH has identified a list of chemicals which have reportedly produced an ob served or suspected carcinogenic or tumorigenic response in animals based upon published articles in the literature. By means of the June 23 Notice, NIOSH is attempting to determine whether any or all of these substances really are carcinogens and, if they are, whether they pose any occupational hazard. For this purpose, all parsons having information or data concerning these chemical substances are requested to submit such information. We urge all of you who have information bearing on the safety or toxi cology of these substances to respond. A number of members of SPI have expre^ sed alarm because included in the list of so-called siis] ected car- cinogens are many substances of direct t to the plastics industry. For example, .ymers listed were polydimethylsiloxane rubber, dSolyeth' polyethylene glycol, polyethylene terephthalate, methacrylate, ^olystyIfpolytetrafluorethylene, polyurett ana ;- polyurethane`plastic, pdlyvinyl chloride, <ol' A/j iry-l. _] nohoT). epsilon-caprolactam polymer, nylon, and carbo: tymethyl cellulose. Another area of concern to the pli istics industry is that many peroxides of interest are also 1: sted such as continued AP00026239 3 In the meantime, all interested parti es should obtain a copy of the list by writing to the 0 ffice of the Federal Register. Furthermore, although the Notice indicates that responses are requested within 90 days, i.e. before September 21, 1975, NIOSH will ac cept information at any time it is submitted. 1 26390 ' . . . . NOTICES J :..^'-department of health. :>.i'V.EDUCATION, AND WELFARE ' ' 'J Center for Disease Control OCCUPATIONAL SAFETY AND HEALTH- Substances List, from which the subset Acting Director.'Office of Research and originated, does not include Information Standard): Development, NIOSH, 5630 on the actual availability, use. or manner of exposure to these chemicals, if any, in the workplace. Therefore, NIOSH is . Fisher* Line (Park Bldg. 3-18), Rockvilie, MD 20852 within 90 days. The areas publishing this list of chemical sub-, of interest include but are not limited Request for Informetlon on Certain .stances, and is requesting additional In .tor..'. v> Chemical Agents :' Section 20(a) (8) of the Occupational Safety and Health Act of 1970 (29 U.S.C. 469(a) (6) 1 direct* the Secretary of V - Health; Education, and Welfare to publtsh at least annually a list <l.e. the Toxic Substances List) of all known toxic substances by generic family or other useful grouping, and the concentration at which uch toxicity Is known to occur. Section . 20<a)<3> of the Act provide* that the Secretary of Health. Education, and Wei- formation with respect to those chemi cals that will be useful for: (1) further development of the Toxie Substances List, (2) on-going evaluation of the "NIOSH Priority List lor Criteria De velopment for Toxic Substances and Physical Agents." (3) preparation of cri teria documents and recommended oc cupational health standards, (4) con duct of the Health Hazard Evaluation Program (42 CFR Part 8S>, and (S) as sistance in determining occupational 1. Production quantities and use and; It the substance Is a contaminant, by-product, or intermediate, the major chemical produced and Ita uees. (Production quantities may be expressed In ranges. Use categories may be renerat t.g coating, solvent etc. and should give an Indication of worker exposure.) 2. Data bn occupational exposure Includ ing concentrations and number of persons exposed. S. Known adverse effects In man or animals Including Observed or suspected carcinogenic, smbryotoxlo. teratogenic, and mutagenic f- - ' fare,, on the basis of information available to him, shall develop criteria for dealing with toxic substances and *ee- `\s tlon 22(c) authorizes the development of recommended occupational safety and health research needs. . facts, and hoy other toxic offsets. The following chemicals are listed al phabetically. Two types of entries are. presented. The first type is the prime entry identified by a seven-digit, perma 4. Toxicologic, clinical, epidemiologic or Industrial hygiene ctudlee In progress or compitted, published or unpublished, Including positive or negative results. 5. Practises in which tht substance Is used V ` ; health standards. ' The National Institute for Oecupa- *tional Safety and Health (NIOSH) has nent accession number from the Toxic ' Substances List file. The first entry also contains the prime name of the chemical identified a set of chemical substances using, as applicable, the convention of > '' ; ? which have reportedly produced an ob- the "Chemical Abstracts 8th Collective i '4 'J`- served or suspected carcinogenic response Index" for pure single substances, the . in animals based upon published articles Chemical Abstract! Service (CAS) reg 7 in the literature.'Dor the purpose of this istry number (as available), and syno S. Alternatives to the use at a substance that may Ims available. , 7. Analy tical and sampling procedures for monitoring the tubstanca In the environ ment or in biological samples (l.s. blood, urine, tisanes, etc.). a. WorX practices tor the use. handling, and transports:.Lon.of the substance.. ' notice, agents causing benign or malig- nyms. The second type of entry is the All infixrelation received concerning ' nant tumors are classed as carcinogens. synonym line referencing trivial, com these subst,ances, except that information This is because of the possibility that agents which cause benign tumors may V.'-'J-S- also produce malignant effects. This set, . r : a subset from the Toxic Substances List, mon, or trade names to the prime-name with its accession number. Any person having information or data in any of the areas listed below, or in which is . trade secret and protected by section 15 of the Act, will be available for public inspection at the foregoing ry;:* doe* not include those carcinogenic other areas considered relevant to the address. * chemicals for which NIOSH has already establishment of a safe anti healthful `i recommended occupational health stand- occupational environment Involving any Dated: May 23. 1975. ards. The data implicating the chemicals of the listed substances, is requested to set forth below in man? cue* are lncon- submit such information Identified by elusive bees ise of Inadequate or ques- the accession number and prime name Eswxitn J. Bsiek, 'Aetlhff Director, National Insti tute for Occupational Safety ,,'' tlonable studies, furthermore, the Toxic with accompanying documentation to the and Health. s'.'''.--1.-. -I.` , Jf '.'$\S+<iSr KOflAt aiOlfTH, VOL 40, NO. 121--MONOAV, JUNI 22, w* -f. -* * f; l . .- . -v .. . -. .; ..i-- AP00026240 SELECTED "SUSPECTED CARCINOGENS FR 40 26390 Acetyl Peroxide Benzoyl Peroxide t-Butyl Peroxide Cadmium Salts Carbon Tetrachloride Chloroform Chromium Salts and Pigments Cumene Hydroperoxide Dyes - many Epoxy Compounds - many Ethanol Ethylene Glycal Formaldehyde Gasoline Exhaust Tar Hydroqulnone Lactose Lauroyl Peroxide Lead Salts Maleic Anhydride Pigments - many Polymers: VC VOH IMA eflon tyrene Irethanes olyethylene lilicones Tristearin Toluene Diamine Zinc Salts APOO