Document DG5O96w9YDpEJYOB5JaBOqd3M

DATA SEARCH ON VCrt/TDXICITY STUDIES FOR CRAIG ELGW Order nurber 911001-135640-WIZ -001-007 page 3 set 13 with 374 of 374 items Item 4 ACCESSION NUh-BER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT ALFTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS xxkxkxk HELD TERMS REVIEM YEAR 4592 GEN CORR FEDERAL REGISTER VINYL CHLORIDE POLYMERS PROPOSAL PUBLISHED IN 1986 BACHTEL HC,BFG* BFG,TO P ZALON (NESTLES FOOD CORP.)* 1990, FEBRUARY 23 FDA*VCM*PVCj RVCM* 1996 Item 5 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 4414 GEN JOURNAL MUTAGENICITY OF VINYL CHLORIDE IN MAN: COMPARISON OF CHROMOSOME ABERRATIONS WITH MICRONUCLEUS AND SISTER-CHROMATID EXCHANGE FREQUENCIES FUCIC ANONE*HORVAT D,NONEDIMITROVIC B,N0NE> MUTATION RESEARCH,VQL. 242 PP. 265-270* 1990 THE MUTAGENIC EFFECTS OF VINYL CHLORIDE MONOMER IN MAN HERE STUDIED IN THE LYMPHOCYTE CULTURE WITH 3 METHODS: THE CHROMOSOME ABERRATION ASSAY, THE MICRONUCLEUS ASSAY AND THE SISTER-CHROMATID EXCHANGE METHOD. COMPARED HITH CONTROL, VALUES OBTAINED BY THESE TESTS ARE INCREASED IN WORKERS OCCUPATIONALLY EXPOSED TO VINYL CHLORIDE. IN RELATION TO NON-SMOKERS, SMOKERS EXPOSED TO VINYL CHLORIDE SHOW SIGNIFICANT INCREASES IN SISTER- CHROMATID EXCHANGE FREQUENCIES. THE PROBLEM OF CORRELATING THE RESULTS OF THE CHROMOSOME ABERRATION ASSAY HITH MICRONUCLEUS AND SISTERCHROMATID EXCHANGE FREQUENCIES IS DISCUSSED. VCM*MUTAGENICITY*MAN*CHROMOSOMAL ABERRATION* INSTITUTE FOR MEDICAL RESEARCH A OCCUPATIONAL HEALTH (YUGOSLAVIA)* 1996 Item 6 ACCESSION NUMBERS FILE LOCATION C-- DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEH YEAR ***** 4409 CORR VCM CANCER RISK ASSESSMENT: C0M1ENTS SUBMITTED TO LOUISIANA DEPT. OF ENVIRONMENTAL QUALITY GOTTESMAN RT,N0NE* NONE,TO LOUISIANA DEPT. OF ENVIRONMENTAL QUALITY FOR BFG* 1991, MAY 30 REVIEH CONCLUDES THAT AN INTERIM AhIENT STANDARD OF 37 UG/M3 AS DERIVED FROM THE 1984 EPA URF OF 2.7X10-6/( UG/M3) IS THE MOST SCIENTIFICALLY SOUND NLfBER AVAILABLE AT PRESENT. VCMlCANCER*RISK ASSESSMENT* VINYL INSTITUTE* 1996 22 o 1 1 DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGLFT Order nwriter 911001-135640-WIZ -001-007 page 4 set 13 with 374 of 374 items Item 7 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS REVIEW YEAR 4359 gen correspondence teratogenicity of vcm aeong hunans none,none* niosh,to department of health, ecfcication, and welfare 1975* december 4 thus* while no conclusive data are available concerning mutagenesis in the hunan setting* such animal and laboratory findings suggest a need for caution with respect to human exposures, from information at hand* therefore* sufficient grounds exist for advising men and especially women in child-bearing years that vcm exposures can lead to an increased risk, teratogenicity *vctn*htaitans 1966 Item 8 ACCESSION NUMBER 4335 FILE LOCATION GEN i DOCUMENT TYPE TITLE OR SUBJECT PAPER PERSISTENT LIVER DYSFUNCTION AMONG WORKERS AT A VINYL CHLORIDE MONOMER POLYMERIZATION PLANT IN SINGAPORE AUTHOR/AFFILIATTON LEE FI,NONE* ORIGIN 't DATE NONE* 1991 ABSTRACT THE FOLLOWING ARE COftiENTS ON A PAPER IN J.SOC.OCCUP.MEO. (1991) 41,10-16 BY S.F.HQ,H.H.PHOON, S.L.GAN AND YK CHAN.THIS STUDY DESCRIBES CHANGES* PRESUMABLY MINOR, IN HEPATIC ENZYME TESTS. FLUCTUATIONS ARE DESCRIBED IN RELATION TO VINYL CHLORIDE EXPOSURE. NO CASE OF VINYL CHLORIDE f INDUCED LIVER DISEASE, OR INDEED ANY OTHER SIGNIFICANT DISEASE, BECAME APPARENT DURING THE SEVERAL YEARS OF THE STUDY. THERE ARE NO CONTROLS. COMMENTS ABOUT THE POSSIBILITY OF SUBSEQUENT DEVEELOPMENT OF ANGIOSARCOMA AND PURELY SPECULATIVE AND WOULD NOT CONFORM WITH SEVERAL PREVIOUS STUDIES IN WHICH THESE MINOR CHANGES HAVE BEEN FOUND WITHOUT CONCURRENT OR SUBSEQUENT EVIDENCE OF c ANGIOSARCOMA. THREE INTERPRETATIONS ARE THEREFORE POSSIBLE. 1. THE LON EXPOSURE LEVELS IN THE ATMOSPHERE AS DESCRIBED ARE CORRECT AND THAT THE LIVER FUNCTION TESTS FLUCTUATIONS ARE A PREVIOUS UNREPORTED ABNORMALITY IN ASSOCIATION TO THIS EXPOSURE. Z. ABNORMAL FINDINGS ARE NOT RELATED TO VINYL CHLORIDE EXPOSURE. 3. THERE HERE UNRECONGIZED DEFECTS IN THE INDUSTRIAL HYGIENE OF THE FACTORY RESULTING IN MUCH HIGHER EXPOSURES TO VINYL CHLORIDE BY THE WORKERS THAN IS SUSPECTED. DESCRIPTORS VCH*LIVER*EFFECTS*WORKERS* REVIEW YEAR 1996 Item 9 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AF FILIATION ORIGIN 4334 GEN JOURNAL PULMONARY EFFECTS OF POLYVINYL CHLORIDE DUST EXPOSURE ON COMPOUNDING WORKERS NG TP,NONE *LEE HS*NONE*LOW YM,NONE)PHOON WH,NONE*NG YL,NONE* NONE,VOL.17 PP. 53-59* .22521004 O u O DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order number 9110CI1-135640-HIZ -001-007 page 5 set 13 with 374 of 374 items DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 1991 SPIROMETRY, CHEST RADIOGRAPHY, ENVIRONMENTAL MEASUREMENTS, AND A QUESTIONNAIRE ON RESPIRATORY SYMPTOMS HERE USED TO EVALUATE THE EFFECTS OF EXPOSURE TO POLYVINYL (PVC) DUST ON 171 CHINESE AND MALAY PVC COMPOUNDING WORKERS IN COMPARISON WITH AN UNEXPECTED REFERENCE GROUP. WORKERS WITH HIGH CUMULATIVE PVC DUST EXPOSURE HAD A LOWER FORCED EXPIRATORY VOLUME IN 1 S AND FORCED VITAL CAPACITY, AND A HIGHER PREVALENCE OR RADIOLOGICAL PROFUSION OF SMALL OPACITIES. WHEEZING OR CHEST TIGHTNESS WAS ALSO SIGNIFICANTLY MORE FREQUENT IN THIS GROUP. UNLIKE PREVIOUS STUDIES, THE PVC COMPOUNDING WORKERS IN THIS STUDY MERE EXPOSED TO ONLY NEGLIGISLE AMOUNTS, IF ANY, OF VINYL CHLORIDE MONOMER OR THERMAL DEGRADATION PRODUCTS OF PVC SUCH AS HYDROGEN CHLORIDE, PHOSGENE, OR CHLORINE. THE CONCLUSION HAS DRAW THAT A LOW GRADE OF PNEUMOCONIOSIS AND A SMALL DEGREE OF LUNG FUNCTION IMPAIRMENT IS ASSOCIATED WITH PVC DUST EXPOSURE. REVERSIBLE AIRWAYS OBSTRUCTION IS ALSO LIKELY AND WARRANTS FURTHER INVESTIGATION. ******* VCM)PVC DUST * RESPIRATORY EFFECTS)OCCUPATIONAL EXPOSURE> SCAND J WORK ENVIRON HEALTH) 1996 Item 10 ACCESSION NUMBER 4325 FILE LOCATION GEN DOCUMENT TYPE TECHNICAL REPORT TITLE OR SUBJECT HEALTH ADVISORIES FOR 25 ORGANICS AUTHOR/AFFILIATION NONE,NONE) ORIGIN EPA,PB87-235578) DATE 1967, MARCH DESCRIPTORS xxxxxxx DRIVING HATER)TOXICITYjAC.RYLAMIDE)BENZENE )CARBON TETRACHLORIDE>CHLOROBENZENE )l,2-DICHLOROETHANE) 1>1-DICHLOROETHYLENE)DICHLOROMETHANE) DIOXIN>EPICHLOROHYDRIN)ETHYLBENZENE *ETHYLENE GLYCOL) BENZENE)METHYL ETHYL KETONE>STYRENE)TETRACHLOROETHYLENE)TOLUENE)11,1-TRICHLOROETHANE) TRICHLOROETHYLENE)VINYL CHLORIDE)XYLENE) HELD TERMS REVIEW YEAR TRANS-1,2-DICHLOROETHYLENE)DICHLOROBENZENE)CIS-1,2-DICHLOROETHYLENE>P-DIOXANE)HEXACHLOROBENZENE) 1995 Item 11 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 4306 GEN PUBLICATION SISTER CHROMATID EXCHANGES, PROLIFERATING RATE INDEX, AND MICRONUCLEI IN BIOMONITORING OF INTERNAL EXPOSURE TO VINYL CHLORIDE MONOMER SIWES B,NONE)SANZ A,NONE)BERNAL MLSAME)TRES A,NCNE)ALCALA A,NONE)LANUZA J,NONE)CEBALLOS C,N0NE) SAENZ MA.NONE) TOX AND APPLIED,VOL 108 PP.37-45) 1991 THE FREQUENCY OF MICRONUCLEK 1*1) SISTER CHROMATID EXCHANGE (SCEs), AND THE PROLIFERATING RATE INDEX IN PERIPHERAL BLOOD LYMPHOCYTES FROM 93 INDIVIDUALS HERE MEASURED. FIFTY-TWO OF THE INDIVIDUALS WERE WORKERS IN THE PLASTICS INDUSTRY HHERE THEY WERE EXPOSED TO VINYL CHLORIDE MONOMER WHILE THE REMAINING 41 INDIVIDUALS HERE WORKERS IN THE PLASTICS INDUSTRY HHERE THEY HERE EXPOSED TO VINYL CHLORIDE MONOMER WHILE THE REMAINING 41 INDIVIDUALS SERVED AS A CONTROL GROUP. IN OUR RESULTS, AN INCREASE OF SCEs AND MN, AS HELL AS INHIBITED CELL KINETICS, WAS OBSERVED IN THE GROUP OF EXPOSED WORKERS. OF THE TESTS USED, SCE WAS FOUND TO BE THE MOST SENSITIVE ENDPOINT DATA SEARCH ON VCK/TOXICITY STUDIES FOR CRAIG ELGUT Order rxuber 911001-135640-NIZ -001-007 page 6 set 13 with 374 of 374 items DESCRIPTORS HELD TERMS REVIEN YEAR FOR INDICATING A BIOLOGICAL RESPONSE. HOWEVER* SINCE METHODS FOR RESTRICTING THE W ANALYSIS TO ONLY CELLS AT RISK (I.E.> SECOND GENERATION INTERPHASE CELLS) HERE NOT USED* THIS STATEMENT REQUIRES VERIFICATION. VCK vWORKERS>CARCINOGEN)TESTS*DNA CYTOGENETIC jSISTER CHROMATIC EXCHANGE* 1995 Item 12 ACCESSION NUTBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS xxxxx: HELD TERMS REVIEW YEAR 4183 GEN CORR DON CHEMICAL COMPANY'S COM1ENTS ON THE CARB 1990 DRAFT TECHNICAL SUPPORT DOCUMENT "PROPOSED IDENTIFICATION OF VINYL CHLORIDE AS A TOXIC AIR CONTAMINANT" HAWKINS NO,DOW CHEM* DOW CHEM>TO BARBARA COOK CARB* 1990, JULY 3 VCM*CANCER*RISK ASSESSMENT*HUMAN*EFFECTS* ANIMAL* 1995 Item 13 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS xxxxx; HELD TERMS REVIEW YEAR 9165 gen report PROPOSED IDENTIFICATION OF VINYL CHLORIOE AS A TOXIC AIR CONTAMINANT: DRAFT REPORTS PART A-C NONE >NONE> NONE * 1990, MAY VINYL CHLORIDE*AIR*DETERMINATION*EFFECTS*TOXICITY> CALIFORNIA AIR RESOURCES BOARD* 1995 Item 14 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS xxxxx? REVIEW YEAR REPORT BUA REPORT ON VINYL CHLORIDE NONE,NONE* CMAjTO R.K.HINDERER(BFG)* 1989, DECEMBER 28 ECOLOGICAL ASPECTS OF THE PRODUCTION, ENTRY INTO, OCCURRENCE AND DISTRIBUTION OF VCM IN THE ENVIRONMENT. VCM)INHALATION)ORAL*EFFECTS*TERATOGEN* 1995 Item 15 22521006 c & <2 % DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order number 911001-135640-HIZ -001-007 page 7 set 13 with 374 of 374 items ACCESSION MONGER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS REVIEW YEAR 4102 GEN REPORT RECOtfflENDATXON FOR THE REVISION OF THE AMBIENT AIR GUIDELINE FOR VINYL CHLORIDE PARK C>D0H CHEMICAL CO) DON CHEMICAL CO,TO ONTARIO MINISTRY OF THE ENVIROW1ENT( DR.M.LUSIS) ) 1989, AUGUST 30 FOUR CONCERNS NEED TO BE ADDRESSED IF DOCUMENT IS TO BE USED AS A BASIS FOR REGULATION. THE CONCERNS ARE AS FOLLOWS:LACK OF DISCUSSION ON INCORPORATION OF LOH-DCSE PHARMACOKINETIC (PK) INFO) LACK OF DISCUSSION OF RISK ESTIMATES THAT HAVE BEEN DERIVED FROM EPIDEMIOLOGY DATAjINTERNAL INCONSISTENCIES IN THE REPORTING OF AMBIENT CONCENTRATION OF VCM IN COMPARISON TO EMISSION LEVELS AND POTENTIAL HUMAN RESULTS. VCMiCAS.NO.75-01-4)EPIDEMIOLOGY)RISK ASSESSMENT)AIR SAMPLING) 1993 Item 16 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT ALTTHQR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS xxxxx; REVIEW YEAR 4085 GEN PUBLICATION MORTALITY AND CANCER INCIDENCE RESULTS OF THE EUROPEAN MULTI-CENTRIC COHORT STUDY OF WORKERS EMPLOYED IN THE VINYL CHLORIDE INDUSTRY. NONE,NONE) IARC* 1989 CONTAINS INTRODUCTION AND DISCUSSION AND CONCLUSIONS. VCM)EPZDEMI0L0GY)HUf1AN)EFFECTS)CANCER)M0RTALZTYjANGX0SARC0MA 1998 Item 17 ACCESSION NUER ; FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS xxxxxxx HELD TERMS COMMENTS REVIEW YEAR 4070 GEN CORRESPONDENCE COMMENTS OF THE VINYL INSTITUTE ON ATSDR'S TOXICOLOGICAL PROFILE FOR VINYL CHLORIDE. NONE,NONE> NONE,TO EPA) 1988 VCM>EPA)ACUTE)TOXICITY)CHRONIC)CANCER)MUTAGENICITY)BIRTH DEFECTS VINYL INSTITUTEt RKH(90) SEE ANf3337 1998 Item 18 ACCESSION NUFBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION 4069 GEN REPORT HEALTH EFFECTS IN CHILDREN EXPOSED TO VINYL CHLORIDE: FINAL REPORT ZISKIND RA,NONE)SMITH D,NONE)SPIVEY G,NONE)ROGOZEN M,NONE> 22321007 BFG52884 i DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order nunber 911001-135640-MIZ -001-007 page 6 set 13 with 374 of 374 items ORIGIN DATE DESCRIPTORS HELD TERMS REVIEW YEAR NONE,FOR EPA CONTRACT NO.68-2986* 1981, JANUARY VCM*EFFECTS*AIR SAMPLINGjQCCUPATIONAL EXPOSURE*DISEASE *REPRODUCTION* SCIENCE APPLICATIONS INC* 1996 Item 19 ACCESSION NUfBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN OATE DESCRIPTORS xxxxx: HELD TERMS KWIC INDEX NUMBER REVIEW YEAR 4068 GEN PAPER REVIEW OF FINAL REPORT ON "HEALTH EFFECTS IN CHILDREN EXPOSED TO VINYL CHLORIDE" WILSON R,HARVARD UNIV* NONE,FOR EPA REFERENCE NO. SA1-068-81-569* 1981, JUNE 18 EFFECTS*VCM* SAUGUS ELEMENTARY SCHOOL* 05215 1996 Item 20 ACCESSION NUMBER 4061 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION i TITLE OR SUBJECT AUTHOR/AFFILIATION CUTANEOUS HAEMANGIOENDOTHELIOMA: A POSSIBLE Lit* WITH CHRONIC EXPOSURE TO VINYL CHLORIDE. DAVIES MFP,NONE*CURTIS M>ONE*HOWAT JMT,NONEl ORIGIN BRITISH J OF INDUSTRIAL MEDICINE,VOL 47 NO.l PP.65-67* DATE 1990 DESCRIPTORS xxxxx: VCM*CANCER>HUHAN*EFFECTS*PVC> HELD TERMS HEMANGIOENDOTHELIOMA * REVIEW YEAR 1998 Item 21 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AF FILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR ***** 4047 GEN CORRESPONDENCE SUWARY AND FINAL STATUS REPORT OF CMA VINYL CHLORIDE PANEL ACTIVITIES. GAFFEY HR,NONE* MONSANTO,W.R.GAFFNEY TO SUSAN HOWE(CMA)* 1989 FURTHER WORK TO RESOLVE THE POSSIBILITY OF MISDIAGNOSIS OF 37 DEATHS TO DETERMINE WHETHER THEY WERE ACTUALLY LIVER AND BILIARY CANCER OR ANGIOSARCOMA IS NOT FEASIBLE. VCH*HUMANEFFECTS*CANCEREPIDEMIOLOGYANGIOSARCONAiLIVER* BILIARY* 1998 Item 22 % a DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order nunfcer 911Q01-135640-MIZ -001-007 page 9 set 13 with 374 of 374 items ACCESSION fWFBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS **** K.HIC INDEX NU-BER REVIEW YEAR 4004 GEN PUBLICATION CLINICAL MANIFESTATIONS IN VINYL CHLORIDE POISONING SUCIU I,NONE>PRODAN L,NONE)ILA ENGNE)PADURARU A,NONE}PASCU L,N0NE) ANNALS OF THE NEW YORK ACADEMY OF SCIENCESPP.53-69} 1970 IN THE 72 CASES ADMITTED TO THE CLINIC THERE HERE 27 POSITIVE HEPATIC TESTS, WITH GOT AND GPT OVER NORMAL IN 18 CASES. BSP(BROMOSULFONPHTHALEIN) IN 22 FROM 26 CASES HAD A RETENTION OVER 5 THE PROTEINOGRAM MODIFICATIONS HERE OF THE ACUTE AND SUBACUTE TYPE. HEPATIC BIOPSY SHOWED CHRONIC HEPATITIS IN 3 CASES. VCM)POISONING^OCCUPATIONAL EXPOSURE )ACUTE>SUBACUTE)HEPATITIS* 05120 1996 Item 23 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS **** KHIC INDEX NUMBER REVIEW YEAR 4003 GEN PUBLICATION TWO POSSIBLE CASES OF ANGIOSARCOMA OF THE LIVER IN A GROUP OF SWEDISH VINYL CHLORIDE-POLYVINYL CHLORIDE WORKERS BYREN D>NONEjHOLMBERG B,NONE) AK4ALS OF THE NEW YORK ACADEMY OF SCIENCES>PP.249-250} 1974 RECENT (JULY 1974) EXAMINATION OF THE PAHTOLOGIC SPECIMENS BY TUMOR SPECIALISTS HAS CONFIRMED THE DIAGNOSIS OF HEKANGIOSARCOKA OF THE LIVER IN BOTH CASES. IN CASE 2 HOWEVER, THERE IS A PROBABLE COEXISTENCE OF A HEPATOCELLULAR CANCER OF BOTH LOW AND HIGH DIFFERENTIATED TYPE. VCM } PVC)ANGIOSARCOMA> LIVERiCANCER}OCCUPATIONAL EXPOSURE) 05122 1996 Item 24 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS 4002 GEN PUBLICATION INTERIM RESULTS OF EXPOSURE OF RATS, HAMSTERS, AND MICE TO VINYL CHLORIDE KEPLZNGER ML,INDUSTRIAL BIO-TEST LABSlGOODE JH,SAME>GORDON DE,SAME)CALANDRA JC,SAME) AhfJALS OF THE NEW YORK ACADEMY OF SCIENCES,PP.219-224) 1974 IN THIS STUDY WHICH WAS DESIGNED TO COMPLEMENT MALTONI'S STUDIES, 100 RATS, HAMSTERS, AND MICE OF BOTH SEXES (600 TOTAL PER EXPOSURE GROUP) ARE BEIN EXPOSED TO EITHER 0, 2500, 200, OR 50 PPM OF VINYL CHLORIDE VAPOR 7 H/DAY 5 DAYS/WEEK. MICE WILL BE EXPOSED FOR 9 MONTHS AND KEPT FOR AN ADDITIONAL 12 MONTHS. MORIBUND AND DEAD ANIMALS (WHEN POSSIBLE) RECEIVE GROSS AUTOPSIES AND ARE PHOTOGRAPHED. THE MAJOR ORGANS OF ALL ANIMALS ARE FIXED FOR HISTOLOGICAL EXAMINATION. IT APPEARS THAT ANGIOSARCOMAS MAY HAVE BEEN OBSERVED IN ONE MALE HAMSTER AND ONE MALE RAT EXPOSED TO 2500 PPM AND IN ONE FEMALE RAT EXPOSED TO 200 PPM. NO TUMORS HAVE BEEN OBSERVED IN RATS OR HAMSTERS EXPOSED TO 50 PPM BUT ONE MALE CONTROL HAS FOUND TO HAVE A DERMAL FIBROMA. TUMORS)RATS)HAMSTERS)DERMAL)VCM)MICE)FIBROMA) O V-' o 1003 % % I DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order number 911001--13564Q-NIZ -001-007 page 10 set 15 with 574 of 374 items 2ZZZW10 KMIC INDEX NUMBER REVIEH YEAR 05123 1996 Item 25 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS **** KWIC INDEX NUMBER REVIEM YEAR 4001 GEN PUBLICATION ANGIOSARCOMA OF THE LIVER AS THE CERTIFIED CAUSE OF DEATH 1963-73 BAXTER PJNONE)FOX AJ,NONE) THE LANCET PP.27-28) 1975, JULY THIS COMMUNICATION REPORTS THE RESULTS IN ENGLAND AND HALES. ALL CERTIFICATES WITH AN IMDERLYING CAUSE OF OEATH OF CERTAIN BENXNG OR MALIGNANT LIVER TUMOURS HERE SCRUTINIZED FOR A DIAGNOSIS OF ANGIOSARCOMA, MALIGNANT HAEMANGIOENDOTHELIOMA, OR KUPFFER CELL SARCOMA. THREE CASES HERE IDENTIFIED. A COMPREHENSIVE FOLLOH-UP OBTAINING A FULL OCCUPATIONAL HISTORY IN EACH OF THESE CASES IS BEING CONDUCTED. ANGIOSARCOMA)LIVER)PVC VCM^CANCER^OCCUPATIONAL EXPOSUREi 05124 1996 <> vn O Item 26 ACCESSION NUMBER 4000 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT PREDICTIVE VALUE OF CARCINOGENESIS BIOASSAYS AUTHOR/AFFILIATION MALTONI C,NONE) ORIGIN ANNALS OF THE NEH YORK ACADEMY OF SCIENCES,PP.431-443J DATE 1970, APPROX ABSTRACT THE POTENTIAL ONCOGENIC RISK FOR MAN BY OCCUPATIONAL AND ENVIRONMENTAL AGENTS HAS SO FAR BEEN IDENTIFIED WHEN THE INCIDENCE OF A PARTICULAR TYPE OF TUMOR IN AN EXPOSED POPULATION HAS BEEN ESPECIALLY HIGH OR ON THE BASIS OF RETROSPECTIVE EPIDEMIOLOGIC STUDIES. HE MUST NOW PREDICT ONCOGENIC RISKS TO AVOID HUMAN EXPOSURE TO SUCH AGENTS. THE THREE MOST IMPORTANT CASES OF ENVIRONMENTAL AND OCCUPATIONAL TUMORS, DISCOVERED AFTER 1970, HERE INDIRECTLY OR DIRECTLY PREDICTED EXPERIMENTALLY. DESCRIPTORS xxxxxxx BIOASSAY(OCCUPATIONAL EXPOSURE)TUMORS)EPIOEMIOLOGY)CANCER)VCM)INHALATION)RATS)MAN)MQUSE)HAMSrER> ANGIOSARCOMA)LIVER)BRAIN}LUNG)SUBCUTANEOUS KWIC INDEX NUFBER 05127 REVIEH YEAR 1996 Item 27 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE 3999 GEN PUBLICATION ANGIOSARCOMA OF THE LIVER IN A VINYL-CHLORIDE HORKER LEE FINONE)HARRY OS,NONE) THE LANCET,PP.1316-1318) 1974, JUNE 29 DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order nuntoer 911001-135640-HIZ -001-007 page 11 set 13 with 374 of 374 items ABSTRACT A MAN AGED 71 YEARS DIED WITH ANGIOSARCOMA OF THE LIVER, AN EXTREMELY RARE TUMOUR. FOR 20 YEARS HEA HAD BEEN A PROCESS WORKER IN THE MANUFACTURE OF POLYVINYL CHLORIDE MONOMER. EVIDENCE APPEARS STRONG THAT ANGIOSARCOMA OF THE LIVER IS AN OCCUPATION TUMOUR AND THAT VINYL CHLORIDE IS THE CARCINOGEN. THERE IS NO EVIDENCE THAT THE FINISHED POLYMERCPVC) CARRIES ANY RISK. DESCRIPTORS xxxxxxx PVC*VChiACROOSTEOLYSIS>ANGIOSARCOKA*LIVER*OCCUPATTONAL EXPOSURE* KWIC INDEX NUTCER 05123 REVIEW YEAR 1996 Item 28 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATIQN ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 3985 GEN PUBLICATION DETERMINATION OF 7-(2-OXOETHYL)GUANINE AND N2 3-ETHENOGUANINE IN DMA HYDROLYSATES BY HPLC FEDTKE N,CIIT*HALKER VE,SAMEjSHENBERG JA,SAME> ARCH TOXICOL,SUPPL 13 PP.214-218* 1989 VINYL CHLORIOE(VC) IS METABOLIZED OXIDATIVELY TO 2-CHLOROETHYLENE OXIDE THAT CAN REARRANGE TO 2-CHLQROACETALDEHYDE. 2-CHLOROETHYLENE OXIDE IS RESPONSIBLE FOR THE FORMATION OF THE MAJOR DNA ADDUCT 7-(2-OXOETHYLJGUANINE (7-OEG) FORMED AFTER IN VIVO EXPOSURE OF EXPERIMENTAL ANIMALS TO VC (LAIB 1986). WHILE 7-OEG DID NOT CAUSE MISPAIRING IN VITRO (BARBIN ET AL 1985), ANOTHER ADDUST, N2,3-ETHENOGUANINE(EG), FOUND IN DNA OF RAT LIVER AFTER VC EXPOSURE (LAIB ET AL 1985), NAS SHOWN TO BE HIGHLY EFFICIENT CAUSING GC->AT TRANSITIONS (SINGER ET AL 1987). UNFORTUNATELY, THE ANALYTICAL EVIDENCE FOR THE IN VIVO FORMATION OF EG PRESENTED BY LAIB ET AL (1985) HAS EQUIVOCAL HENCE, THE FIRST GOAL OF THIS STUDY HAS TO PROVE OR DISPROVE THE IN VIVO FORMATION OF EG. THE SECOND GOAL HAS TO DETERMINE THE SENSITIVITY NEEDED TO STUDY THE DOSE-RESPONSE RELATIONSHIP BETWEEN VC EXPOSURE AND TARGET TISSUE DOSE MEASURED AS DNA ADDUCTS. NEW HPLC METHODS FOR QUANTIFYING 7-OEG AND EG BY FLUORESCENCE SPECTOPHOTOMETRY WERE DEVELOPED. DETECTION LIMITS HERE 15 AND 1.4 PMOL PER UMOL GUANINE FOR 7-OEG AND EG, RESPECTIVELY. IN THE CASE OF EG, ADDITIONAL QUALITATIVE EVIDENCE FOR ITS PRESENCE HAS OBTAINED BY A HIGHLY SPECIFIC GC-MS METHOD. VCM*DNAjMETABOLISM* DNA ADDUCTS*DNA BINDING* 1995 Item 29 ACCESSION NUMBER 3984 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT COMPARISON OF POTENCY OF HUMAN CARCINOGENS: VINYL CHLORIDE, CHLOROMETHYLMETHYL ETHER AND BIS( CH LOROMETHYL)ETHER AUTHOR/AFFILIATION VAN DUUREN BL,N0NE* ORIGIN ENVIRONMENTALRESEARCH,VOL 49 PP.143-151* DATE 1989 ABSTRACT ON THE BASIS OF THESE NUMBERS OF CANCER DEATHS, AND THE LEVELS AND DURATIONS OF EXPOSURE, IT IS CONCLUDED THAT VC IS A WEAK HUMAN CARCINOGEN COMPARED TO CME-BCME. DESCRIPTORS x**xxx VCM*CANCER*HUMAN*EFFECTS*BCME) HELD TERMS REVIEW YEAR CHLOROMETHYLMETHYL ETHERjCME* 1999 22a210il % I DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order rxxnber 911001-135640-WIZ -001-007 page 12 set 13 with 374 of 374 items Item 30 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SLBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS xxxxx: HELD TERMS KHIC INDEX NUMBER REVIEW YEAR 3964 GEN JOURNAL VINYL CHLORIDE FORMATIN FROM THE THERMAL DEGRADATION OF POLY(VINYL CHLORIDE) WAKEMAN IBjTENNECO CHEMICALS;JOHNSON HR,SAME; NONE,VOL 2 NO.3 PP.200-203; 1980, SEPTEMBER THE VOLATILE PRODUCTS FROM THE THERMAL DEGRADATION OF POLY(VINYL CHLORIDE)(PVC) RESINS AND COMPOUNDS ARE SHOW TO CONTAIN TRACE AMOUNTS OF VINYL CHLORIDE. PVC;VCM^COMBUSTION;TOXICITY>THERMAL DECOMPOSITION; J OF VINYL TECHNOLOGY; 04819 1992 Item 31 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** KHIC INDEX NUMBER REVIEW YEAR 3941 GEN PUBLICATION COMBUSTION PRODUCTS FORM VINYL CHLORIDE MONOMER O'MARA MM,BFG;CRIDER LB,SAME;DANIEL RL,D0H CHEM> AIHA.VOL 32 PP.153-156 1971, MARCH BY MEANS OF A VARIETY OF ANALYTICAL TECHNIQUES, THE COMBUSTION PROFILE OF VINYL CHLORIDE MONOMER!VCM) HAS BEEN DETERMINED. THIS PROFILE INCLUDES FLAME TEMPERATURES, SOOT CONTENT, AND A COMBUSTION GAS ANALYSIS. DEPENDING ON THE AMOUNT OF VCM-AIR PREMIXING PRIOR TO COMBUSTION, THE TEMPERATURE OF A VCM FLAME RANGES FROM 950 DEG TO 1466 DEG C. SIMILARLY, THE SOOT OR UMBURNED CARBON CONTENT OF A VCM FLAME VARIES FROM 3 TO 6 WEIGHT PERCENT. AN ANALYSIS OF THE COMBUSTION GASES FROM VCM REVEAL THE FOLLOWING COMPOSITION: HCL 27,000 PPM; C02 58,100 PPM; CO 9500 PPM; PHOSGENE 40 PPM; AND VCM TRACE. FROM A HAZARD STANDPOINT, THE GROSS QUANTITY OF HYDROGEN CHLORIDE IS THE MAIN SOURCE OF DANGER IN A VCM FIRE. VCM>COMBUSTION;TOXICITY;THERMAL DECOMPOSITION; 00950 1992 Item 32 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SIBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 3924 GEN JOURNAL COHORT AND CASE-CONTROL ANALYSES OF WORKERS EXPOSED TO VINYL CHLORIDE; AN UPDATE HJ W,NQNE;STEENLAND K,NONE;BROMW D,NONE;WELLS V,N0NE;J0NES J,NONE;SCHULTE P>N0NE;HALPERIN H,N0NE; J OF OCCUPATIONAL MEDICINE,VOL 31 NO.6 PP.518-523; 1989, JUNE THE ONLY SIGNIFICANT ASSOCIATION BETWEEN DISEASE RISK AND CUMULATIVE DOSE MAS FOR LIVER CANCER AND CUMULATIVE DOSE OF VINYL CHLORIDE MONOMER. FURTHER DIVISION OF THE LIVER CANCERS INTO ANGIOSARCOMA (N=I2) AND OTHER LIVER CANCERS (N=7), BASED ON REVIEH OF DEATH CERTIFICATES AND Ol \n O I DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order rxjnber 911001-135640-MIZ -001-007 page 13 set 13 with 374 of 374 items DESCRIPTORS REVIEW YEAR MEDICAL RECORDS , SHOWED THAT THE DOSE RESPONSE EXISTED ONLY FOR ANGIOSARCOMAS. xxxxxxx VCMjPVC OUSTiANALYSIS>HORKERSEXPQSURE> 1997 Item 33 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS xxxxx: HELD TERMS REVIEH YEAR 3921 GEN PUBLICATION INCREASED ALKYLATION OF LIVER DNA AND CELL TURNOVER IN YOUNG VERSUS OLD RATS EXPOSED TO VINYL CHLORIDE CORRELATES WITH CANCER SUSCEPTIBILITY LAIB RJ,NONEjBOLT HM>NQNE}CARTIER RIARCjBARTSCH H.IARC! TOXICOLOGY LETTERS.VOL 45 PP.231-239! 1989 VCM>CANCER)DNA^TRANSPLACENTAL CARCINOGENLIVER)EFFECTSi DNA ALKYLATION! 1997 Item 34 ACCESSION NUMBER 3919 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT 1.N6-ETHENO-21-DEOXYADENOSINE AND 3 .N4-ETHEN0-Z1-DEOXYCYTIDINE DETECTED BY MONOCLONAL ANTIBODIES IN LUNG AND LIVER DNA OF RATS EXPOSED TO VINYL CHLORIDE. AUTHOR/AFFILIATION EBERLE G,NONE>BARBIN A;NONE!LAIB RJ,NQNE*CIROUSSEL F.NONE!TH0MALE J NONE )BARTSCH H.NONE)RAJEWSKY i MF.NONE! ORIGIN NONE.VOL 10 NO.l PP.209-212! DATE 1989 DESCRIPTORS xxxx-xxx VCM!DNA!CANCER!MUTAGENICITY! HELD TERMS MONOCLONAL ANTIBODIES)DNA ADDUCTSiCARCINOGENESIS! REVIEW YEAR 1997 Item 35 ACCESSION NUMBER \ 3915 FILE LOCATION --GEN'"' DOCUMENT TYPE REPORT TITLE OR SUBJECT VCM TOXICITY SUMMARY. AUTHOR/AFFILIATION HINOERER RK.BFG! ORIGIN BFG! DATE 1988 ABSTRACT THIS SUMMARY HAS PREPARED TO ADDRESS IMUJNOTOXICITY ALLEGATIONS. DESCRIPTORS **xxxxx VCM!CANCER!TOXICITY!BIRTH DEFECTS JLIVERiEFFECTS)ANGIOSARCOMA) HELD TERMS IMMUfOTOXICITY>ACRO-OSTEOLYSIS! REVIEW YEAR 1997 Item 36 ACCESSION NUTOER 3903 BFG52890 \7Ji.1 ,5 i DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order nuri>er 911001-135640-WIZ -001-007 page 14 set 13 with 374 of 374 items FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS xxxxxxx HELD TERMS REVIEW YEAR GEN REPORT THE MUTAGENICITY AND CARCINOGENICITY OF VINYL CHLORIDE NONE*NONE) NONE'TECHNICAL REPORT N0.31) 1988 VCM)MUTAGENICITY)CANCER ECETOC) 1997 A HISTORICAL REVIEW AND ASSESSMENT Item 37 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** KHXC INDEX NUH3ER REVIEW YEAR 3882 GEN PROCEEDINGS CONFERENCE TO REEVALUATE THE TOXICITY OF VINYL CHLORIDE* POLYVINYL CHLORIDE AND STRUCTURAL ANALOGUES NONE,NONE* NIH,WITH NIOSH/NIEHS AS COSPONSORS) 1980, MARCH 20 VCM)PVC|HUMAN)EFFECTS)CHLORINATED HYDROCARBONS)MICE)RATS) 04763 1991 Item 38 ACCESSION NUhBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS xxxxxx* HELD TERMS KWIC INDEX NUtBER REVIEW YEAR 3680 GEN PUBLICATION THE MUTAGENICITY OF VINYL CHLORIDE AFTER METABOLIC ACTIVATION RANNUG U,NONE)JOHANSSON A,NONE)RAMEL C,NONE)WACHTMEISTER CA,NONE) AMBIO,VOL 3 NO.5 PP.194-197) 1974 VCM)METABOLISM)MUTAGENICITY)IN VITRO) ACTIVATION 01052 1991 Item 39 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 3875 GEN PUBLICATION CONGENITAL CENTRAL NERVOUS SYSTEM MALFORMATIONS* KANAWHA COUNTY, WEST VIRGINIA NONE,NONE) CDC EPI-76-60-2) 1976, JULY 26 DATA AVAILABLE THROUGH THE BIRTH DEFECTS MONITORING PROGRAM (BDMP) REVEALED THAT FORM 1970 THROUGH 1974, KANAWHA COUNTY, WEST VIRGINIA-- WHERE 1 OF THE 40 POLYVINYL CHLORIDE PRODUCTION PLANTS IN THE UNITED STATES IS LOCATED--HAD RATES OF CONGENITAL CENTRAL NERVOUS SYSTEM DEFECTS 22521014 % \ % DATA SEARCH ON VCM/TQXICITY STUDIES FOR CRAIG ELGUT Order number 911001-135640-WIZ -001-007 page IS set 13 with 374 of 374 items THAT WERE SIGNIFICANTLY HIGHER THAN NATIONAL BDMP RATES FOR THOSE YEARS. DESCRIPTORS xxxxxxx VCMjBIRTH DEFECTS)CNS)TERATOGENICITY)HUHAN)EFFECTS)EPIOEMIOLOGY> KWIC INDEX NUtBER 02556 REVIEW YEAR 1991 Item 40 ACCESSION NUTOER SK* FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT PUBLICATION THE EFFECT OF MATERNALLY INHALED VINYL CHLORIDE ON EMBRYONAL, FETAL AND POSTNATAL DEVELOPMENT IN RATS AUTHOR/AFFILIATION ORIGIN DATE MIRKOVA E>NONEjMICHAILOVA A,NONE)HINKOVA L,NONE)NASKO M.NONE* NONE > 1970 ABSTRACT THE RESULTS SHOWED THAT VINYL CHLORIDE CAUSED AN INCREASED FETAL MORTALITY AND FREQUENCY OF HAEMORRHAGES AND A DECREASED FETAL HEIGHT. VINYL CHLORIDE WAS TERATOGENIC AT THE CONCENTRATION USED. TERATOGENIC EFFECTS CONSISTED OF EXTERNAL (ENCEPHALOCELE)> INTERNAL SOFT TISSUE ABNORMALITIES iHYDROCEPHALUS, BRAIN HAEMORRHAGES) AND SKELETAL MALFORMATIONS (DOUBLES OSSIFICATION CENTRES IN THE STERNUM). VINYL CHLORIDE PRODUCED ALSO BIOCHEMICAL AND FUNCTIONAL DISTURBANCES IN THE HOMEOSTASIS OF THE FETAL ORGANISM AND THE OFFSPRING. A DECEASED ACTIVITY OF THE DEHYOROGENASES--G6PDH,SUCDH,I-CDH,MDH,LDH AND AN INCREASED ACTIVITY OF GAMA-GTP HAS ESTABLISHED IN THE FETAL LIVER. VINYL CHLORIDE CAUSED AN INCREASED G6PDH AND I-CDH ACTIVITY IN THE FETAL BRAIN. THE INDEX OF FERTILITY AND GESTATION IN THE PROGENY HAS DECREASED. THE EXCRETORY, DETOXIFYING AND ENZYMIC FUNCTIONS OF THE LIVER, AS HELL AS THE NERVOUS SYSTEM NERE INJURED IN THE THREE GENERATIONS OF THE OFFSPRING. DESCRIPTORS xxxxxxx VCM)TERATOGENICITY)FETAL TOXICITYJINHALATIONJEMBRYOTOXICITY> KWIC INDEX NUMBER 04056 REVIEW YEAR 1991 Item 41 ACCESSION NUTBER 3B70 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT THE DYNAMICS OF VINYL CHLORIDE INDUCED ACROOSTEOLYSIS AUTHOR/AFFILIATION MYSLAK Z,NONE)GLUSZCZ MN0NE) ORIGIN UNKNOW) DATE 1977 ABSTRACT THESE OBSERVATIONS SHOW THAT IN VC-INDUCED OSTEOLYSIS NO REAL LESION OF DONE STRUCTURE OCCURS* AND THAT THE ACROOSTEOLYSIS IS REVERSIBLE. DESCRIPTORS xxxxxxx VCM)ACROOSTEOLYSIS)HUMAN)EFFECTS) HELO TERMS INSTITUTE OF OCCUPATIONAL MEDICINE) KWIC INDEX NUMBER 04057 REVIEW YEAR 1990 Item 42 ACCESSION NUMBER FILE LOCATION 3869 GEN & Cl vO Q Tv* r?\ i DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order number 9U001-13S640-KIZ -001-007 page 16 set 13 with 374 of 374 items DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** HELD TERMS KHIC INDEX NUMBER REVIEW YEAR PUBLICATION HISTOLOGICAL AND ELECTRON MICROSCOPE STUDIES UPON THE LONG-TERM TOXICITY OF VINYL CHLORIDE IN RATS, WITH SPECIAL REFERENCE TO LIVER CHANGES STETKIEHICZ J>NQNEiKOLAKOHSKI J,NONEjZDRAJKOHSKA I,NONEjSZENDZIKOHSKI S,NONE) UNKNOWN 1977 VCM UNHALATION jRATSiCHRONIC)EFFECTS)TOXICITY INSTITUTE OF OCCUPATIONAL MEDICIf( POLAND)) 04059 1990 Item 43 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS wxxxxxx HELD TERMS KHIC INDEX NUMBER REVIEW YEAR 3868 GEN PUBLICATION METABOLISM OF VINYL CHLORIDE MONOMER IN THE LIVER OF RATS HISNIEHSKA-KNYPL JM>N0NEiTARKOHSKI S,NONE)DRAMINSKI H,NONE) UNKNOW) 1977 VCM)METABOLISM)RATS)LIVER)INHALATION) INSTITUTE OF OCCUPATIONAL MEDICINE(POLAND)) 04060 1990 Item 44 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS **** KHIC INDEX NUMBER REVIEW YEAR 3867 GEN TECHNICAL REPORT AMBIENT HATER QUALITY CRITERIA FOR VINYL CHLORIDE NONE,NONE) EPA,PB81-117B89) 1980, OCTOBER THE LEVELS WHICH MAY RESULT IN INCREMENTAL INCREASE OF CANCER RISK OVER THE LIFETIME ARE ESTIMATED AT 10-5,10-6, AND 10-7. THE CORRESPONDING RECOTttENDED CRITERIA ARE 20 UG/L, 2.0 UG/L, AND 0.2 UG/L, RESPECTIVELY. IF THE ABOVE ESTIMATES ARE MADE FOR CONSUMPTION OF AQUATIC ORGANISMS ONLY, EXCLUDING CONSUMPTION OF HATER, THE LEVELS ARE 5,246 UG/L, 525 UG/L, AND 52.5 UG/L, RESPECTIVELY. VCM)HATER) 04085 1990 Item 45 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT 3P REPORT REVIEW AND AUDIT OF IBT NO. 663-03222, CHRONIC VAPOR INHALATION TOXICITY STUDY WITH VINYL CHLORIDE (ETHYLENE DERIVED) IN ALBINO RATS, ALBINO MICE ANO GOLDEN HAMSTERS FOR THE MANUFACTURING 22521018 % % DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order rxmfcer 911001-135640-HIZ -001-007 page 17 set 13 with 374 of 374 items CHEMISTS ASSOCIATION AUTHOR/AFFILIATION BOB WEST,NONE* ORIGIN NONE,FOR IDT) DATE 19Q0, APRIL 14 DESCRIPTORS xxxxxx* VCM INHALATION ) RATS )MICE )HAMSTERS)CARCINOGENICITY {CHRONIC )TOXICITY > HELD TERMS AUDITsBOB WEST ASSOCIATES) KHIC INDEX NUMBER 04593 REVIEW YEAR 1990 Item 46 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS xxxxx. KHIC INDEX NUCBER REVIEH YEAR 3862 : GEPT' REPORT EPIDEMIOLOGY STUDY ON VINYL CHLORIDE WORKERS AT SHAHINI6AN PLANT: FRENCH VERSION THERIAULT G,NONE)ALLARD P,NONE) NONE) 1980 VCM)EPIDEMIOLOGY)HUMAN)EFFECTS) 04749 1990 Item 47 ACCESSION NUWER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS xxxxx: HELD TERMS KHIC INDEX NUtSER REVIEH YEAR 3860V REPORT PATHOLOGY REPORT ON THE BRAINS FROM MICE,HAMSTERS* AND RATS EXPOSED TO VINYL CHLORIDE IN IBT STUDY 663-03222 NONE,NONE) NONE) 1980, KAY 14 VCM)BRAIN)MICE)RATS)HAMSTERS)tNHALATl0N)CARCII40GENXCITY)CHR0NIC)T0XICmr) EXPERIMENTAL PATHOLOGY LABORATORIES)AUDIT) 04667 1990 Item 48 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 3859 GEN REPORT VINYL CHLORIDE CARCINOGENICITY BIOASSAYS (BT PROJECT) AS AN EXPERIMENTAL MODEL FOR RISK IDENTIFICATION AND ASSESSMENT IN ENVIRONMENTAL AND OCCUPATIONAL CARCINOGENESIS MALTONI C,NONE)LEFEMINE G,NONE)CILIBERTI A,NONE) COTTX GN0NE)CARRETT1 D,N0NE) NONE,MEETING HELD AT INSTITUT CURIE (PARIS,FRANCE)) 1979, NOVEMBER 10 ANGIOSARCOMA (1 AT 10 PPM INHALATION AND 1 AT 0.3 MG/HG ORAL AND MORE AT HIGHER DOSES), EXTRA-HEPATIC ANGIOSARCOMAS, HEPATOMA, ZYMBAL GLAND CARCINOMA, NEPHROBLASTOMAS AND NEUROBLASTOMAS FOUND IN RODENTS EXPOSED TO VCM. 22521017 <5T ox \n O y* & o o o i'-l DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order rumfcer 911001-135640-HIZ -001-007 page 18 set 13 with 374 of 374 items 22521018 DESCRIPTORS *** HELO TERMS KHIC INDEX NUMBER REVIEW YEAR VCM >CARCINOGENICITY )ANGIOSARCOMA)ZYM)AL GLANDjRATSjMICEjHAMSTERSj HEPATOMA)NEPHROBLASTOMA>reUROBLASTOMA*RODENTS 04712 1990 Item 49 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS KWIC INDEX NUteER REVIEW YEAR 3858 GEN PUBLICATION A COMMUNITY VINYL CHLORIDE MORTALITY ANALYSIS STUDY ITURRA H>LAVAL UNIV) NONE,SPECIAL MTG ON TOXIC SUBSTANCES IN THE AIR ENV1R0M1ENT) 1976 STUDY COMPARES THE MORTALITY PROFILE OF PEOPLE FROM A COItiUNITY EXPOSED TO VINYL CHLORIDE INTO ITS ENVIRONMENT KITH THE MORTALITY PROFILE OF A CONTROL COMMUNITY MATCHED FOR DEMOGRAPHY AND INDUSTRIALIZATION. THE TWO POPULATIONS DO NOT DIFFER BUT FOR HALES AGED BETWEEN 20 AND 64. IN THIS LATTER GROUP, FIVE CANCER TYPES ARE MORE PREVALENT IN SHAHINIGAN THAN IN DRUMMONDVILLE. THEY ARE CANCERS OF THE LIVER, THE PANCREAS, THE BRAIN, THE LUNG AND THE BLADDER. MORE STUDIES ARE NEEDED TO ASCERTAIN THE ORIGIN OF THESE CANCERS WHETHER IT IS THROUGH EXPOSURE AT WORK OR IN THE ENVIRONMENT. VCM)EPIDEMIOLOGY)CANCER)LIVER>BRAIN)LUNG)PANCREAS)BLADDER) APCA* 04756 1990 Item 50 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS **** HELD TERMS KWIC INDEX NUTOER REVIEW YEAR GEN PROCEEDINGS AN EPIDEMIOLOGY DESCRIPTION OF 10 CANADIAN CASES OF ANGIOSARCOMA OF THE LIVER DELORME FNONE) NONE,SPECIAL MEETING ON TOXIC SUBSTANCES IN THE AIR ENVIRONMENT* 1976 TEN CASES OF ANGIOSARCOMA OF THE LIVER HERE DIAGNOSED AMONG WORKERS OF A VINYL CHLORIDE POLYMERIZING PLANT IN SHAHINIGAN, QUEBEC, SINCE 1974. AN EPIDEMIOLOGICAL QUESTIONNAIRE HAS COMPLETED BY MEETING KITH RELATIVES AND FRIENDS OF THE CASES. THE PRESENT PAPER DESCRIBES THE OCCUPATIONAL HISTORY ALONG HITH THE ALCOHOL CONSUMPTION, THE SMOKING HABITS, THE PASSED DISEASES AND OTHER RELEVANT INFORMATIONS OF THESE INDIVIDUALS. FURTHERMORE, IT STUDIES THE RELATIONSHIP BETWEEN THE TIME OF FIRST EXPOSURE, THE DURATION OF EXPOSURE, THE MORPHOLOGICAL ASPECT OF THE HEPATIC LESIONS AND A BRIEF EXPOSITION OF THE PATHOGENESIS OF THE DISEASE. ANGIOSARCOMA)VCM >HUNANEFFECTS}EPIDEMIOLOGY) APCA) 64758 1990 Item 51 ACCESSION NUtCER 3856 I I DATA SEARCH ON VCM/TOKICITY STUDIES FOR CRAIG ELGUT Order nunber 911001-135640-WIZ -001-007 page 19 set 13 with 374 of 374 items FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS KHIC INDEX NUMBER REVIEW YEAR GEN^J) PAPER HEALTH EFFECTS OF EXPOSURE TO VINYL CHLORIDE IN A CANADIAN C0M1UNITY THERIAULT 6>LAVAL UNIV* NONE>SPECIAL MEETING ON TOXIC SUBSTANCES IN THE AIR ENVIRONMENT* 1976 THE PURPOSE OF THE PAPER IS TO DESCRIBE BRIEFLY THE RESEARCHES THAT ARE GOING ON AT LAVAL UNIVERSITY ON THE HEALTH EFFECTS OF EXPOSURE TO VINYL CHLORIDE IN A CANADIAN COMMUNITYt SHAHINX6AN). THE THREE MAIN STUDIES INCLUDE A DESCRIPTION OF THE 10 CASES OF ANGIOSARCOMA OF THE LIVER FOUND AMONG VC WORKERS IN CANADA. A MORTALITY STUDY OF THE COMMUNITY EXPOSED TO VC AND A PROPOSAL FOR A BIRTH DEFECTS STUDY IN THE CONCERNED COrtfJNITY. VCM*ANGIOSARCOMA*BIRTH DEFECTSjHlMAN(EFFECTS* APCA> 04757 1990 Item 52 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS *xx*x: KHIC INDEX NUCBER REVIEH YEAR 3855 GEN JOURNAL MUTAGENICITY OF HASTE PRODUCTS FROM VINYL CHLORIDE INDUSTRIES RAMEL C.UNIV OF STOCKHOLMjRANMJG U,SAME* J OF TOXICOLOGY AND ENVIRONMENTAL HEALTH,VOL Z PP.1019-1029* 1977 ' THE RESULTS SHOHED THAT EDC-TAR CONTAINED DIRECT AS NELL AS INDIRECT MUTAGENIC CONSTITUENTS. VCrUMUTAGENIcrmiN VITROjEDCjTAR* 04092 1990 Item 53 ACCESSION NUTBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEH YEAR 3846-^ GEN REPORT REASSESSMENT OF LIVER CANCER AMONG VINYL CHLORIDE WORKERS NONE,NONE* NONE,FOR CMA) 1989, FEBRUARY ATTEMPTED FOLLOH-UP OF 37 LIVER CANCER CASES IDENTIFIED IN EARLIER REPORT. INCOMPLETE DATA RECOVERY, BUT INCORRECT DIAGNOSIS IS INDICATED IN SOME CASES WITH A REDUCTION BUT NOT ELIMINATION OF STATISTICALLY SIGNIFICANT EXCESS. VCM*LIVER(CANCER* ENSR HEALTH SCIENCES* 1992 Item 54 ACCESSION NUMBER FILE LOCATION 3833 GEN oo.-ro.* % o & o DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order nunfeer 9UQ01-13564Q-HIZ -001-007 page 20 set 13 with 374 of 374 items DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR PUBLICATION TOXICITY OF VINYL CHLORIDE AND P0LY<VINYL CHLORIDE).* A CRITICAL REVIEW WAGONER JK,N0NE) ENVIROr*IENTAL HEALTH PERSPECTIVES,VOL 52 PP. 61-661 1983 THE TARGET ORGANS FOR VC NOHCLEARLY INCLUDE THE LIVER,BRAIN AND THE LUNG, AND PROBABLY THE LYMPHOHEMATOPOIETIC SYSTEM.THE EVIDENCE FOR A CARCINOGENIC RISK HAS BEEN EXTENDED TO JOBS ASSOCIATED WITH POLY(VINYL CHLORIDE) EXPOSURE. CASES OF LIVER ANGIOSARCOMA HAVE BEEN REPORTED AMONG' INDIVIDUALS EMPLOYED IN PVC FABRICATION FACILITIES AND AN EPIDEMIOLOGICAL STUDY HAS DEMONSTRATED A SIGNIFICANT ASSOCIATION BETWEEN EXPOSURE TO PVC DUST AND THE RISK OF LUNG CANCER MORTALITY. CASES OF ANGIOSARCOMA OF THE LIVER ALSO HAVE BEEN REPORTED AMONG INDIVIDUALS LIVING IN NEAR PROXIMITY TO VINYL CHLORIDE-POLYCVINYL CHLORIDE )PLANTS. AN ASSOCIATION BETWEEN PVC DUST AND PNEUMOCONIOSIS ALSO HAS BEEN DEMONSTRATED. ON THE BASIS OF FINDINGS, PRUDENT CONTROL OF PVC DUST IN THE INDUSTRIAL SETTING IS INDICATED. VINYL CHLORIDE)PVC DUST)LUNGS)CANCER)AOL) PNEUMOCONIOSIS) 1996 Item 55 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS xxxxx*x HELD TERMS REVIEW YEAR 3797 gen CORRESPONDENCE report on the 1986 industrial direct discharges in ONTARIO! RESPONSE TO COMMENTS BY RK HIWJERER. Ian q,none) NONE,TO BFG> 1988 AQUATIC TOXICITY >MUTAGENICITY)EFFECTS)VCK) BROCK UNIV) AQUATIC)TOXICITY) 1990 Item 56 ACCESSION NUMBER 3763 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT ACROOSTEOLYSIS AND ASSOCIATED CUTANEOUS LESIONS IN TWO WORKERS INCURRED IN THE CLEANING OF AUTOCLAVES. AUTHOR/AFFILIATION CORDIER JH,NQNE)FIEVEZ C,NONE)LEFEVRE MJ,NONE)SEVRIN A,NONE) ORIGIN NONE,VOL.4 NQ.l) DATE 1966 ABSTRACT TRANSLATION DESCRIPTORS **xxx*x ACROOSTEOLYSXS)VCH HELD TERMS CAHIERS DE HEDECXNE DU TRAVAIL) KHIC INDEX MJtBER 04791 REVIEW YEAR 1996 Item 57 ACCESSION NUMBER 3645 22521020 O' OO <s v/"> o CO i DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order number 911Q01-135640-HIZ -001-007 page 21 set 13 with 374 of 374 items FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS xxxxx; HELD TERMS KWIC INDEX NUtCER REVIEW YEAR GEN PUBLICATION DISTRIBUTION OF PRIMARY CANCERS OF THE LIVER IN THE PROVENCE OF QUEBEC JACOB PJ >N0NE *THERIAULT GP>NONE) NONE>VOL 112 PP.305-307) 197S VCM)HUMAmEFFECTS)CANCER)LIVER)ANGIOSARCOMAl CMA J)CANADIAN MEDICAL ASSOCIATION J* 01650 1996 Item 58 ACCESSION NUMJER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AF FILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** REVIEW YEAR report cohort end case-control analyses of workers exposed to vinyl chloride - an ipdate. HU H>N0NEiSTEENLAND K>NIOSH)BROHN D,NIOSH)HELLS V,NIOSHjJONES J*NIOSH)SCHULTE P*NIQSH)HALPERIN H, NIOSH) niosh* to bfg) 1988 there was an association between vcra and liver cancer. however* there was no relationship between vcm or pvc and brain or lung cancer. cancer)liver)brain)lung)angiosarcoma)vcin)pvc)hiiiian)effects)epideiniology 1990 Item 59 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS xxxxxxx REVIEH YEAR GEN CORRESPONDENCE VCM FOUND IN TOBACCO SMOKE ROEMER CN>N0NE) KELLER AND HECKMAN) 1988 IARC VOL 38 LISTS VCM IN TOBACCO SMOKE. VCM)T0BACC0 SMOKE )CO**USTION)CANCER>TOXICITY) 1996 Item 60 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS xxxxxxx REVIEW YEAR 3376 gen publication update to vinyl chloride mortality study. OAHAR WS>D0H CHEM)BOND GG*D0N CHEM)MCLAREN EA,SAME)SABEL FL,SAME)LIPPS TE>SAME>CQOKRR*SAME) journal of occupational medicine* vol.S0(8) pp.648-9) 1988 vcra)hunan)effacts)epidemiology)cancer)chronic 1996 22521021 cP qx cP. \T> o DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order ncmber 911001-135640-NIZ -001-007 page 22 set 13 with 374 of 374 items Item 61 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS REVIEW YEAR Item 62 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 337S GEN PUBLICATION TOXICITY OF VINYL CHLORIDE-POLYVINYL CHLORIDE:A COMPILATION OF PAPERS PRESENTED AT A NYAS WORKSHOP VELTMAN G,NONE)LANGE CE>NONE(LILIS RNONE(MILLER A,NONE(SUCIU I,NONE(BERK PD.NONE(SAKABE H,N0NE( HYATT RH,NONE(CREECH JL,NONE)MARSTELLER HJN0NE( HEFNER RENONE)OSTER G,N0NE(JAEGER RJ,N0NE WAGNER ER,NONE)PRODAN L,N0NE( VOLKHEIHER GNONE(POPPER HNONE(MALTONI C,NONE(KEPLINGER ML,NONE) NICHOLSON HJ,NONE(HEATH CHNONE(SCHNEXDERMAN MA,NONE(BYREN D*N0NE( HANCUSO TFNQNE(VAN DWJREN BL NONE (THOMAS LV,NONE(GAY BW,NONE) SCHWEITZER GENONE)CORN M,NONE(ROHE VKNONE(PERKEL G,NQNE( BELICZKY L,N0NE( JOHNSON CANQNE(DOLL R,NOt(HEIhANN H,N0NE( ANNALS OF THE NEW YORK ACADEMY OF SCIENCES,VOL 246 PAPERS PRESENTED AT A WORKSHOP SPONSORED BY NYAS,ACS,NIEH$,NIH,SOCIETY FOR OCCUPATIONAL A HEALTHtMAY 10-11,1974) 1975, JANUARY 31 VOLUME CONTAINS FOUR PARTS: TOXICOLOGICAL INVESTIGATIONS OF VINYL CHLORIDE-POLYVINYL CHLORIDE VIA CLINICAL STUDIES, EXPERIMENTAL STUDIES,PATHOLOGY(CARCINOGENESIS ASSOCIATED WITH VINYL CHLORIDE VIA EXPERIMENTAL STUDIES, EPIDEMIOLOGICAL STUDIES,PATHOLOGY (ENVIRONMENTAL CONSIDERATIONS) CONTROL AND MANAGEMENT. EPIDEMIOLOGY (VINYL CHLORIDE (VCM)PVC (TOXICITY (CARCINOGENICITY (MORTALITY ( 1996 3374 GEN PUBLICATION CONFERENCE TO REEVALUATE THE TOXICITY OF VINYL CHLORIDE MONOMER,POLYIVINYL CHLORIDE) AND STRUCTURAL ANALOGS: ENVIRONMENTAL HEALTH PERSPECTIVES (EHP) COMPILATION OF PAPERS PRESENTED ON VC, PVC AND STRUCTURAL ANALOGS HAXNEILER PJ>N0NE(MALTONI CjNONE(SUZUKI Y,NONE(GROTH DH>NONE(RADIKE MJ,NONE(HEHIR RM,NONE(WAGNER JC,NONE(INFANTE PFNONE(HEBER H,NONE( COOPER WC,NONE(FALK H,NONE(BAXTER PJ,N0NE(TArtHJRRO CH,N0NE( WHEELER RN,NONE( JONES JH>NONE(CHIA2ZE L,NONE(MOLINA G,NONE(MASTRANGELO G,NONE(LILIS R,NONE( JOHN JA,NONE(RICE JM,NONE(FABRICANT JD,NONE (HATCH M,NONE(DIMMICK WF,N0NE( VIATMA NJ,NONE(CHU KC,N0NE> APFELDORF R,NONE(HATTXS D,N0NE( ENVIROtHENTAL HEALTH PERSPECTIVES,VOL 41 CONTAINS PAPERS FROM NIH CONFERENCE MARCH 20-21(1960)) 1961, OCTOBER CONTAINS MOST EXTENSIVE ANIMAL RESEARCH ON THE CARCINOGENICITY OF VCM EVER PUBLISHED. DOSE-RESPONSE CURVES CAN BE EXAMINED BY SITE AND TYPE OF TUMOR, BY ROUTE AND SCHEDULE OF EXPOSURE, AND BY SPECIES AND STRAIN OF ANIMAL. THE UPDATED EPIDEMIOLOGIC STUDIES PRESENTED IN THIS VOLUME OF MORTALITY AMONG WORKERS EXPOSED TO VC REINFORCE THE LABORATORY FINDINGS OF MULTISITE CARCINOGENICITY. DATA DEMONSTRATING THE MUTAGENIC AND TRANSPLACENTAL EFFECTS OF VCM ARE ALSO UPDATED AND SUtlARIZED, THE CARCINOGENICITY OF PVC DUST IS EVALUATED BOTH EXPERIMENTALLY AND EPIDEMIOLOGICALLY IN THESE PROCEEDINGS. THE RESULTS ARE NOT DEFINITIVE. TOXICITY)VINYL CHLORIDE(PVC(RATS(MAN)EPIDEMIOLOGY(CARCINOGENICITY(INHALATION(MOUSE(LUNGS(EFFECTS) PVC DUST(RISK ASSESSMENT (VCM) PNEUMOCONIOSIS) 1996 O' ai cA \n O DOCUMENT TYPE publication TITLE OR SUBJECT follow-143 study on the carcinogenicity of vinyl chlonoe arra v mice: tumor incidence and mortality subsequent to exposure, AUTHOR/AFFILIATION hong cb,none)winston jmnone)thornburg lp,none)lee cc>nona) ORIGIN J OF TOXICOLOGY AND ENVIRONMENTAL HEALTH,V0L.7 pp.909-92*) DATE 1981 DESCRIPTORS xxxxxxx vcm)cancer>RAT)effacts REVIEW YEAR 1996 Item 65 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS xxxxxxx HELD TERNS REVIEW YEAR 3550 gen report commity risk assessment, downs td,none) NONE,VOL 37 PP.118-124} 1978 VCM)HUMAN)RAT5)EFFECTS)CANCER)RISK ASSESSMENT) TEXAS REPORTS ON BIOLOGY A MEDICINE) 1996 Item 66 ACCESSION NUt-BER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE 3337 gen report atsdr toxicological profile for vinyl chloride, none,none) NONE,FOR EPA) 1986 DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order nutfcer 911001-135640-WI2 -001-007 page 24 set IS with 374 of 374 items DESCRIPTORS HELD TERMS REVIEW YEAR xxxxx** VCK)HUMAN)EFFECTS)RATS) TECHNICAL RESOURCES INC) 1990 Item 67 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** HELD TERMS REVIEW YEAR 3259 gen publication development of technique* to monitor for exposure to vinyl chloride: monoclonal antibodies to e thenoadenos ine. yowg tl*none)santella ra>none NONE,VOL 9 NO.4 PP.589-592) 1988 VCM^BIOLOGICAL MONITORING)RISK assessment CARCINOGENESIS) 1996 Item 68 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** HELD TERMS REVIEW YEAR 3238 gen publication study of mortality among chemical workers in the Kanawha valley of west Virginia, rinsky ra>none)ott g>noneward enone)graonbarg hnone)halperin w*nona)leet t,none) americen j of industrial medicine* vol 13 pp.429-438) 1988 increase in liver and lyapo- and reticulosarcoma seen in e cohort of 29,139 males. vcm)epidemiology)hMnan)effects)eancer)liver) LYMPHOPOIETIC) 1996 Item 69 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 3207 GEN PUBLICATION EFFECT OF VINYL CHLORIDE ON TESTIS IN RATS BI M*NONE)NANG Y*N0NE)M HUANG*N0NE)MEN6 D*NQNE) NONE*VOL 10 NO.3 PP.281-289) 1985 THE AUTHORS EXPOSED HALE RATS TO 0* 10, 100 * 3000 PPM VCM* 6HR/D, 6D/kK FOR 12 MONTHS WITH OBSERVATION THROUGH 18 MONTHS. THIS WORK IS NOT HELL REPORTED. THEY INDICATE A DECREASE IN TESTICULAR ORGAN TO BODY HT RATIO IS DUE TO VCM. HOWEVER* THIS EFFECT HAS SEEN ONLY AT 6 MONTHS* NOT AT THE 3* 12* AND 18 MONTHS OBSERVATIONS. THIS SUGGESTS THAT THIS EFFECT MAY BE AN ARTIFACT RATHER THAN VCM-RELATED. THE AUTHORS COULD HAVE PERSUED THIS FURTHER BY COMPARING ORGAN TO BRAIN KT RATIOS. THE AUTHORS ALSO REPORT SEMINIFEROUS TUBULES DAMAGED (DISAPPEARANCE OF SPERMATIDS* SPERMATOCYTS) IN 3 CATAGORIES 10-50* 50-100, AND MORE THAN 100. THERE HAS AN INCREASE IN THE INCIDENCE OF ANZMALS WITH CHANGES AT 100 AND 3000 PPM* BUT THIS INCREASE APPEARED TO BE LIMITED TO LOW GRADE (10-50) CATEGORY BECAUSE THE RELATIVE OCCURRENCE IN THE 3 CATEGORIES DID NOT CHANGE 22521024 BFG52901 DATA SEARCH ON VCM/TOXXCITY STUDIES FOR CRAIG ELGUT Order number 911001-135640-MIZ -001-007 page 25 set 13 with 374 of 374 items DESCRIPTORS HELD TERMS REVIEW YEAR WITH DOSE. THIS IN ITSELF WOULD SUGGEST THAT, IF COMPOUND RELATED, VCM WOULD NOT BE EXPECTED TO CAUSE AND REPRODUCTIVE BECAUSE THERE IS NO EVIDENCE OF AN INCREASE IN SEVERITY OF DAMAGE WITH DOSE. IF THE AUTHORS HAD PROVIDED INFORMATION ON WHEN THESE CHANGES HERE OBSERVED (3, 6, 12, OR 18 MONTHS) IT MIGHT HAVE BEEN EASIER TO DETERMINE THE RELEVANCE OF THESE OBSERVATIONS TO VCM. *** VCM)CHRONIC)EFFECTS)TESTES)REPRQDUCTION> ECOTOXICOLOGY & ENVIRONMENTAL SAFETYjSPERM* 1996 Item 70 ACCESSION NUTOER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** REVIEW YEAR 3203 gen publication increasing evidence of the rise of cancer in workers exposed to vinylchloride. smulevich vb,none)fedotova iv,none>filatova vs,none) British j of industrial medicine, vol 45121 pp.93-97) 1988 authors allege leukemias end lymphomas in the study grot^> end the absence of angiosarcomas reflect the action of different levels of van. vcm)angiosarcoma)leikemia)lymphoma>cancer}human)effects)epidemiology 1996 Item 71 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 3201, gen report potential effects of vinyl chloride on hunan offspring, none,none) NONE) 1987 vcm does not cause birth defects or miscarriages, but is of concern as e potential transplacental carcinogen. VCM)BIRTH DEFECTS)REPRODUCTION)EFFECTS)CANCER)HUMAN) VINYL INSTITUTE > 1996 Item 72 ACCESSION NUfBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** KWIC INDEX NUTOER REVIEW YEAR 3159 gen publication mortality study of workers in polyvinyl-chloride production plant, duck bw,none)carter jt,noneicoorbas ej,none) the lancet, pp.1197) 1975 1 case of angiosarcoma fotnd in a cohort of 2100 workers exposed to vcm for up to 27 years. vcm)angiosarcoma) liver )humameffoots 02613 1996 2<"js f AO r*~ BFG52902 j o DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order number 911001-135640-HIZ -001-007 page 26 set 13 with 374 of 374 items Item 73 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS xxxxx** KMC INDEX NUT6ER REVIEH YEAR 3148 gen publication angiosarcoma of the liver among printers. Herbert jt,none) UNKNOWN* 1976 5 cases identified) possble link to vcm suggested. vcm )angiosarcoma)liver)hunan)effacts 02331 1996 Item 74 ACCESSION NUt-BER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS xjhhhh HELD TERMS REVIEH YEAR 3129 gen publication vinyl chloride contaminations the hidden threat, wolf k,none)holland r,none)rajaratnam anone) NONE,VOL IS PP.163-184) 1987 . discusses vcm in ground water end sanitary landfills. VCM)WATER) GROUND HATER)LANDFILL)J OF HAZARDOUS HASTE) 1996 Item 75 ACCESSION MJt-BER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN 0ATE ABSTRACT DESCRIPTORS XXXXXXX REVIEH YEAR 3115 gen report literature search on pvc degradaTXON. none,none) NONE,NONE) 1987 no evidence that pvc is degraded in soil or water to vcm vcm)pvc)degradation)biodegradation>water 1990 Item 76 ACCESSION NUTBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN correspondence angiosarcoma case report* DRUWRXGHT JR,NONE) NONE,TO BFG) 2252102S DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order nurfoer 9110Q1-135640-HIZ -001-007 page 27 set 13 with 374 of 374 item* DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 1987 angiosarcoma case in a pvc worker, vcm>pvc*angiosarcoma*Kjnan*effacts VISTA CHEMICAL CO* 1992 Item 77 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** HELD TERMS REVIEW YEAR 3113 gen report literature search on the degradation of tee to vcm. none*nones NONE*NONEs 1987 tee is biodegraded to vcm. vcm*trichlorcethylene|degradaiion*biodegradation*HATER| DIALOG INFORMATION SERVICES* GROUNDHATER)SOIL* 1994 Item 78 ACCESSION NLRBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** REVIEW YEAR 3112 gen LITERATURE SEARCH literature search vcm/reproductive effects, none*nones NONE*NONE* 1987 vcm*birth defects*reproduction*effects 1994 Item 79 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** REVIEW YEAR 3111 ffen publication spontaneous abortions among women employed in the plastics industry, linbohn m>noneihemminki k*nona*kyyronen pnone* AMERICAN J OF INDUSTRIAL MEDICINE,VOL 8 PP.579-586* 1985 vcmjbirth defects*reproduction*hisnan*affacts*epideaiology*mutagenicity*taratoganicity 1994 Item 80 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT 3110 gen publication the use and abuse of subgroup analysis in epidemiological research. 2 zr*w-? r-o/W.4JL n' o --** b FG504 i DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order nunber 911001-13S640-HIZ -001-007 page 28 set 13 with 374 of 374 items AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** REVIEW YEAR stallone ranone> preventive medicine* vol 16 pp.183-194) 1987 critique of infante study of genetic risks of vcm. van* reproductiombirth defects{epidemiology)teratogenicity)husan)effects(mutagenicity 1994 Item 81 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS xxxxxxx REVIEW YEAR 3109 gen publication genetic risks of vinyl chloride. paddle ^n*none) the lancet* pp.1079) 1976* may 15 VCMiBIRTH DEFECTSjREPRODUCTION )EFFECTS)HUMAN)teratogenicity)nutagenicity)epidemiology 1994 Item 82 ACCESSION NUMBER 3108 FILE LOCATION gen DOCUMENT TYPE publication TITLE OR SUBJECT genetic risks of vinyl chloride. t AUTHOR/AFFILIATTON infante pf>nioshswagoner jk*niosh)mcniichael ajniosh)waxMmiler rj >niosh)falk hniosh) ORIGIN the lancet* pp.734-735) DATE 1976* april 3 ABSTRACT AUTHORS REPORT EXCESS FETAL LOSS ZN HIVES OF WORKERS EXPOSEO TO VCM. HOWEVER* THESE RESULTS ARE QUESTIONABLE BECAUSE OF STUDY FLAKS (SEE MAC MAHON* 1977* VINYL CHLORIDE AND HUMAN REPRODUCTION AND DOMS ET AL> 1977, VINYL CHLORIDE* BIRTH DEFECTS AND FETAL WASTAGE A CRITICAL REVIEW.) DESCRIPTORS ***** vcmireproduetionjbirth defects{mutagenicity)human)effects>teratogenicity{epidemiology>FETAL TOXICITY) KWIC IN0EX NUMBER 01669 REVIEW YEAR 1994 Item 83 ACCESSION NUfBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS xx**xx HELD TERMS REVIEW YEAR 3105 gen report literature search on vcm immnotoxieity. none,none) NONE,NONE) 1987 vcm does not causa imninodeficiency. VCM) IHMUN0TDXICXTY)ItlfffJNODEFICIENCY {DIALOG INFORMATION SERVICES) 1994 7TO vn c> o\ vn O DATA SEARCH ON VCM/TQXICITY STUDIES FOR CRAIS ELGUT Order rxsnber 911001-135640-HIZ -001-007 page 29 set 13 with 374 of 374 items 22521023 Item 64 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT 3096 GEN GUIDELINES NATIONAL PRIMARY DRINKING HATER REGULATIONS FOR CERTAIN VOLATILE SYNTHETIC ORGANIC CHEMICALS--MONITORING FOR UNREGULATED CONTAMINANTS: FINAL RULE AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT NCNE.NONE) FEDERAL REGISTER.VOL 52 NO.130 PP.25690-25717) 1987> JULY 8 THE REGULATIONS SET MAXIMUM LIMITS OF 0.002 MILLIGRAM PER LITER OF VINYL CHLORIDES.005 MILLGRAM PER LITER FOR BENZENE.CARBON TETRACHLORIDE. 1*2-DICHLOROETHANE AND TRICHLOROETHYLENE*0.007 MILLIGRAM PER LITER FOR 1,1-DICHLOROETHYLENE(0.075 MILLIGRAM PER LITER FOR PARA-DICHLOROBENZENE1 AND 0.2 MILLIGRAM PER LITER FOR 1,1.1-TRICHLOROETHANE. THE REPORTING REQUIREMENTS REQUIRE PUBLIC HATER SYSTEMS TO REPORT MONITORING DATA TO STATES WITHIN SPECIFIED TIME PERIODS. AND THE PUBLIC NOTIFICATION PROVISIONS REQUIRE EACH PUBLIC HATER SYSTEM TO GIVE NOTICE TO PERSONS IT SERVES IF IT VIOLATES THE MCLS (MAXIMUM CONTAMINANT LEVELS) OR FAILS TO COMPLY NXTN THE MONITORING DESCRIPTORS HELD TERMS REVIEW YEAR REQUIREMENTS. a****** TRICHLOROETHYLENECARBON TETRACHLORIDE)1.1.1-TRICHLOROETHANE(VINYL CHLORIDE(1.2-DICHLOROETHANE ( BENZENE)!, 1-DICHLOROETHYLENElORBKING HATER(MONITORING(CONTAMINANTS) NPDH PARA-DICHLOROBENZENE) 1992 Item 85 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ****** HELD TERMS REVIEW YEAR 3097 gen publication incidence of cancer among vinylchloride end polyvinylchloride workers association with maligiant melanoma, ten bergs wf .none) BRITISH J OF INDUSTRIAL MEDICINE,VOL 44 NO.10 PP.718-719) 1987 vcm)cancer)human>ef feets) MELANOMA) 1994 further evidence for an Item 86 ACCESSION NUCBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS *** REVIEW YEAR 3096 gen publication exposure to vinyl chloride monomer: report on e cohort study, laplanche a,none)clavel f.nonsicontassot j-cnone)lanouziere c.none) BRITISH J OF INDUSTRIAL MEDICINE,VOL 44 NO.10 PP.711-715) 1987 vcm (human(affects(epidemiology(angiosarcoma 1994 f- BFG52906 9 9 9 DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order nunber 911001-135640-WIZ -001-007 page 30 set 15 with 374 of 374 items Item 67 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS *xxxxx HELD TERMS REVIEW YEAR 2970 gen piblication effects of exposure to vinyl chloride: an assessment of' the evidence. doll r,none) NONE,VOL 14 NO.2 PP.61-78) 1988 review and critique of epidemiology studies of vca exposed populations. vcm>cancer)angiosarcoma)human)effects>epidemiology SCANDINAVIAN J OR NORK ENVIRONMENT HEALTH) 1996 Item 68 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** HELD TERMS REVIEW YEAR 2967 gen publication a scientific basis for the risk assessment of vinyl chloride. NONE,NONE) NONE,VOL 7 PP.120-127) 1987 risk assessments based on animal and hunan data are presented, it is concluded that continuous exposure to .001 mg/m(3) corresponds to a risk of 10(-6) per lifetime, vanjcancer)risk assessment )RATS)effacts )hunan REGULATORY TOXICOLOGY & PHARMACOLOGY) 1996 Item 69 ACCESSION NUWJER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTH0R/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS xxxxaxx REVIEW YEAR 2963 gen publication risk of angiosarcoma in workers exposed to vinyl chloride as predicted from studies in rats. GEHRING PJ,D0H CHEMICAL C0)NATANABE PGSAME)PARK CNSAME) toxicology and applied pharmacology, vol 49 pp. 15-21) 1979 the predicted incidence of hepatic angiosarcoma using the probit modal is 1.5x10(-8). vcm)rat)angiosarcoma)cancer)risk assessment 1996 Item 90 c ACCESSION NUMBER FILE LOCATION 2838 GEN DOCUMENT TYPE PAPER TITLE OR SUBJECT A MORTALITY STUDY OF VINYL CHLORIDE MONOMER WORKERS EMPLOYED IN THE UNITED KINGDOM 1940-1974 AUTH0R/AFFILIATION JONES RD,N0NE)THOMAS P6,N0NE)SM1TH DM,NONE) 22521*)3 G 5 ^ 01 DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order rwnfcer 911001-135640-WIZ -001-007 page 31 sat 13 with 374 of 374 items ORIGIN DATE ABSTRACT DESCRIPTORS REVIEW YEAR ICI* 1987 MAY 22 THE MORTALITY EXPERIENCE OF 5,498 MALE WORKERS EMPLOYED FOR AT LEAST ONE YEAR DURING 1940-1974 IN THE UK VINYL CHLORIDE INDUSTRY NAS FOLLOWED THROUGH TO DECEMBER SI, 1984. NON-SECONDARY LIVER TUMORS ACCOUNTED FOR 11 DEATHS, (11/1.94, P<0,001) OF WHICH 7 HERE ANGIOSARCOMAS. ALL ANGIOSARCOMA DEATHS OCCURRED IN AUTOCLAVE WORKERS WITH A MEDIAN LATENCY FROM DATE OF FIRST EXPOSURE OF 25 YEARS. A STRONG HEALTHY WORKER EFFECT NAS SEEN. OTHER THAN FOR THE LIVER, NO INCREASED INCIDENCE OF CANCER DEATHS ATTRIBUTABLE TO VCM EXPOSURE HAS FOLMD. THERE HAS NO EVIDENCE OF INCREASED MORTALITY FROM CHRONIC LIVER DISEASE. THE INCIDENCE OF DEATH FROM RESPIRATORY DISEASE NAS LON AND NAS NOT AFFECTED BY PVC DUST EXPOSURE. EPIDEMIOLOGY*VCM*MORKERS*EFFECTS* 1995 Item 91 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS xxxx HELD TERMS REVIEW YEAR 2833 GEN PUBLICATION STUDY OF ILLNESSES DUE TO VINYL CHLORIDE SUCIU I,NONE*DREJMAN I,NONE*VALASKAI M,NQNE NONE,VOL 58 N0.4 PP.261-271* 1967 EARLY DESCRIPTION OF THE EFFECTS OF HIGH EXPOSURES TO VCM. VCM*ACUTE*HUMAN*EFFECTS*SKINRAYNAUD,S SYNDROME *SCLERODERMA* LA MEDICINA DEL LAVORO* 1995 Item 92 ^. ACCESSION NUMBER ^^ 2780^-^ FILE LOCATION ~SHT DOCUMENT TYPE REPORT TITLE OR SUBJECT AN UPDATE OF AN EPIDEMIOLOGY STUDY OF VINYL CHLORIDE WORKERS (1942-1982) AUTHOR/AFFILIATION HONG,NONE * ORIGIN CMA* DATE 1986, OCTOBER 17 ABSTRACT THE COHORT CONSISTED OF 10,173 MEN WHO HAD WORKED FOR AT LEAST ONE YEAR IN JOBS INVOLVING EXPOSURE TO VINYL CHLORIDE PRIOR TO JANUARY 1, 1973. THESE MEN HERE EMPLOYED AT 37 PLANTS IN THE U.S., BELONGING TO 17 COMPANIES. OBSERVATION OF THE MORTALITY EXPERIENCE OF THE COHORT NAS EXTENDED FROM DECEMBER 31, 1972 TO DECEMBER 31, 1982. A TOTAL OF 1536 COHORT MEMBERS HERE IDENTIFIED TO HAVE DIED. THE OBSERVED MORTALITY, BY CAUSE, NAS COMPARED WITH THE EXPECTEO BASED ON U.S. MORTALITY RATES, STANDARDIZED FOR AGE, RACE AND CALENDAR TIKE. ANALYSES BY LENGTH OF EXPOSURE, LATENCY, AGE AT FIRST EXPOSURE, CALENDAR YEAR OF FIRST EXPOSURE AND TYPE OF PRODUCTS WERE PERFORMED. THE STUDY CONFIRMED THAT THE VINYL CHLORIDE WORKERS EXPERIENCED SIGNIFICANT MORTALITY EXCESSES IN ANGIOSARCOMA (15 DEATHS), CANCER OF THE LIVER AND BILIARY TRACT (SMR=641), AND CANCER OF THE BRAIN AND OTHER CENTRAL NERVOUS SYSTEM (SMRa180). IN ADDITION, THE STUDY ALSO FOUND A SIGNIFICANT MORTALITY EXCESS IN EMPHYSEMA (SMR=179). ON THE OTHER HAND, THE STUDY DID NOT FIND ANY EXCESS IN EITHER RESPIRATORY CANCER OR LYMPHATIC AND HEMATOPOIETIC CANCER. DESCRIPTORS xxxxi VCMjPVC HUMAN*EFFECTS*EPIDEMIOLOGY*ANGIOSARCOMA*CANCER*LIVER>BRAIN>CNS*EMPHYSEMA* HELD TERMS BILIARY TRACT* ZZ5Z1031 DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order nurfcer 911001-135640-NIZ -001-007 page 32 set 13 with 374 of 374 items REVIEH YEAR 1995 Item 93 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS *xxx* REVIEH YEAR 2778 GEN REPORT MORTALITY STUDY OF 5000 VC MANUFACTURERS IN NINE ITALIAN PLANTS BELLI ET ALNONE NONE,NONE 1986 INTERIM REPORT. PVC >VCM ^EPIDEMIOLOGY |HUMAN)EFFECTS J CARCINOGENICITY ) 1988 B fG 5 09 Item 94 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATICN ORIGIN DATE ABSTRACT DESCRIPTORS REVIEH YEAR 2619 GEN PUBLICATION VINYL CHLORIDE: AN ASSESSMENT OF THE RISK OF OCCUPATIONAL EXPOSURE PURCHASE IFH,NONE)STAFFORD J,NQNEtPAODLE GMICI) NONE>VOL 25 NO.2 PP.187-202} 1987 ALTHOUGH PRECISE ESTIMATES OF EXPOSURE ARE NOT AVAILABLE FOR THE PERIODS OF HOST INTEREST* THE PATTERN OF CASES ROUGHLY SUGGESTS THAT EXTREMELY HIGH EXPOSURES HERE NECESSARY FOR THE INDUCTION OF ANGIOSARCOMA OF THE LIVER (ASL). ANGIOSARCOMA}LXVERlVCMiRISK ASSESSMENT)OCCUPATIONAL EXPOSURE} 1992 Item 95 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** REVIEH YEAR 2615 gen publication incidence of cancer among vinyl chloride and polyvinyl chloride workers: association with malignant melanoma, heldaas ss>none}andersen aanona}langard *>nonei BRITISH J OF INDUSTRIAL MEDICINE>VOL 44 NO.4pp.278-260) 1987 vcm)pvc)skin)hLmian)affects 1995 further evidence for an Item 96 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION 2486 GEN PUBLICATION REVIEH OF PULMONARY EFFECTS OF POLY(VINYL CHLORIDE) AND VINYL CHLORIDE EXPOSURE LXLXS R>NONE) DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order nusber 911001-135640-HIZ -001-007 page 33 sei 13 with 374 of 374 items 22521033 ORIGIN DATE DESCRIPTORS HELD TERMS COMMENTS REVIEW YEAR ENVIRONMENTAL HEALTH PERSPECTIVES>VOL 41 PP.167-169) 1981 PVC DUST)PULMONARY FUNCTION)EFFECTS)VCH)CARCINOGENICITY) IMMUN0TOXICITY ) RKH(87) DOCUMENT ON SHELVES. 1995 Item 97 0 5 1 9 ' ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** HELD TERMS COMMENTS REVIEW YEAR 2485 GEN PUBLICATION THE EFFECTS OF ORGANIC COMPOUNDS USED IN THE MANUFACTURE OF PLASTICS ON THE RESPONSXVITY OF MURINE AND HUMAN LYMPHOCYTES THURMAN G8>N0NE)Sir*t5 BG,NONE)GOLDSTEIN ALN0NE)KILIAN DJ,N0NE) TOX AND APPLIED,VOL 44 NO.3 PP.617-641) 1978 VCM)HUMAN)MZCE)EFFECTS) IttlUNOTOXICITY) RKH(87) DOCUMENT ON SHELVES. 1995 Item 98 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS COMMENTS REVIEW YEAR ***** 2484 GEN PUBLICATION IfttUNOLOGIC EFFECTS OF VINYL CHORIDE IN MICE SHARMA RPtNONE)GEHRING PJ,NONE) ANNALS OF THE NEW YORK ACADEMY OF SCIENCES,VOL 320 PP.551-563) 1979 METABOLITES OF VCM MAY BE REPSONSIBLE FOR THE STIMULATION OF LYMPHOCYTE TRANSFORMATION OBSERVED IN SPLENIC CULTURES. VCM)MICE)EFFECTS) IWIUMOTOXICITY) RKH(87) DOCUMENT ON SHELVE5. 1995 Item 99 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS 2482 GEN JOURNAL ItnUNOTOXICOLOGIC STUDIES WITH VINYL CHLORIDE IN RABBITS AND MICE SHARMA RP,NONE)YAKEL HO,DON CHEMICAL CO)GEHRXNG PJ,SAME) NONE,VOL 2 PP.295-299) 1980 THE STUDY INDICATED THAT ALTHOUGH VCM HAY CAUSE AN APPARENT ENHANCEMENT OF IMMUNE REACTIVITY, IT DOES NOT ALTER THE XIWUNOLOGXC REPSONSE TO SIMULTANEOUSLY ADMINISTERED ANTIGENS. VCM)MICE)RABBITS)EFFECTS) DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAZ6 ELGUT Order nurfcer 911001-135640-NIZ -001-007 page 34 set 13 with 374 of 374 items HELD TERMS REVIEW YEAR IMiUNOTOXCCITYlINTERNATIONAL J OF ItfiUNOPHARMACOLOGY) 1995 Item 100 ACCESSION NUF6ER 2481 FILE LOCATION GEN DOCUMENT TYPE TITLE OR SUBJECT PUBLICATION GENETIC SUSCEPTIBILITY TO SCLERODERMA-LIKE SYNDROME INDUCED BY VINYL CHLORIDE AUTHOR/AFFILIATION SLACK CM>NONEjMALKER AEN0NE)CATOGGX0 U,N0NE)NELSH KINONEjBERNSTEIN RM>N0NE)MCGREGOR AR,N0NE) LLOYD JONES JK.NONE) ORIGIN THE LANCET* PP.53-551 DATE 1983 ABSTRACT VARIOUS ANTIGENS WERE OBSERVED IN WORKERS WITH ''VCM DISEASE11.1 S DESCRIPTORS *x**xx* VCM)HUMAN)EFFECTS)RAYNAUD'S SYNDROME) HELD TERMS IMMUNOTOXICITY) REVIEW YEAR 1995 Item 101 ACCESSION NUTOER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS xxxxxxx HELD TERMS REVIEW YEAR 2480 GEN PUBLICATION CHEMICAL INTERACTIONS AND COMPROMISED XtMJNE SYSTEM SHARMA RPNONE) NONE,VOL 4 PP.345-351) 1984 THE IMMUNOSTIMULATING EFFECT OF VCM IS DISCUSSED. VCM ) HUMAN)EFFECTS)MICE) IMMUNOTOXICITY )FUNDAMENTAL A APPLIED TOX) 1995 Item 102 ACCESSION NUFBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS *xxxxxx HELD TERMS REVIEH YEAR 2479 GEN JOURNAL HISTOCOMPATIBILITY ANTIGENS (HLA) IN DERMATOLOGY ROWELL NR,NONE) BRITISH J OF DERMATOLOGY,VOL 3 PP.347-357) 1984 VARIOUS ANTIGENS WERE FOUND IN PATIENTS WITH 'VCM DISEASE*. VCM)HUMAN)EFFECTS)RAYNAUD'S SYNDROME) IM1UN0TQXICITY) 1995 Item 103 ACCESSION NUMBER FILE LOCATION 2478 GEN 22521034 BFG 52911 DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order nurfcer 911001-135640-WIZ -001-007 page 35 set 13 with 374 of 374 items DOCUMENT TYPE TITLE OR SUBJECT PUBLICATION THE IM1UNOTOXICITY OF SELECTED ENVIRONMENTAL CHEMICALS,PESTICIDES AND HEAVY METALS AUTHOR/AFFILIATION EXON JH,NONE) ORIGIN NONE,PP.355-368 > DATE ABSTRACT 1984 A REVIEN OF STUDIES INDICATES THAT VCM CAUSES HYPERACTIVE HUMORAL IH*JNE RESPONSES AND APPEARANCE OF CIRCULATING IMMUNE COMPLEXES. DESCRIPTORS xxxxxx* VCM)HUMAN)EFFECTS)RAYNAUD`S SYNDROME) HELD TERMS IMMUNOTOXICITY )UNIV OF IDAHO) REVIEW YEAR 1995 Item 104 ACCESSION NUMBER 2477 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT VASCULITIC PURPURA IN VINYL CHLORIDE DISEASE: A CASE REPORT AUTHOR/AFFILIATION MAGNAVITA N>N0NE)BERGAMASCHI A,NONE)GARCOVICH A>NONE)GIULIAN0 G,NONE) ORIGIN NONE,VOL 37 NO.5 PP.382-388) DATE ABSTRACT 1986 THE FINDINGOF INCREASED CIRCULATING IIHUNE COMPLEXES AND ANTI-SMOOTH MUSCLE AUTOANTIBODIES STRENGTHENS THE HYPOTHESIS THAT IFMUNOLOGIC CHANGES PLAY A ROLE IN THE APPEARANCE OF 'VINYLIC PURPURA1. DESCRIPTORS xxxxxxx VCM)HUMAN)EFFECTS)RAYNAUD'S SYNDROME) HELD TERMS IhtiUNOTOXICITY REVIEW YEAR 1995 Item 105 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR xxxxx; 2476 GEN PUBLICATION CRYOGLOBULINEMIA IN RAYNAUD'S PHENOMENON DUE TO VINYL CHLORIDE LANGAUER-LEHONICKA H>N0NE)DUDZIAK Z,NONE)BYCZXOHSKA ZNGNE) INTERNATIONAL ARCHIVES OF OCCUPATIONAL ENVIROMiENTAL HEALT,VOL 36 PP.197-207) 1976 RAYNAUD'S PHENOMENON NAS DESCRIBED IN 22 VCM POLYMERIZATION WORKERS. INCREASES IN IMMUNOPROTEIN AND COMPLEXES WERE OBSERVED. VCM)HUMAN)EFFECTS)RAYNAUD *S SYNDROME) IMMUNOTOXICITY 1995 Item 106 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AF FILIATION ORIGIN 2475 GEN JOURNAL IMMUNOLOGICAL MECHANISMS ZN THE PATHOGENESIS OF VINYL CHLORIDE DISEASE HARD AM,NONEjUDNOON S,NONE)WATKINS J,NONE)WALKER AE,NONE)DARKE CS,N0NE> BRITISH MEDICAL JOURNAL,VOL 1 PP.936-938) 22Lj21033 BfG 5 2 9 ^ DATA SEARCH ON VCN/TOXICITY STUDIES FOR CRAIG ELGLTT Order rwnber 911001-135640-WIZ -001-007 page 36 set 13 with 374 of 374 items DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 1976> APRIL 17 IMMUNOLOGICAL INVESTIGATIONS REVEALED THE PRESENCE OF CIRCULATING IMMUNE COMPLEXES IN 19 OF 28 PATIENTS WITH 'VCM DISEASE1 AND 2 OF 30 WORKERS WHO HERE EXPOSED TO VCM. VCMsHUMANjEFFECTSjRAYNAUD'S SYNDROME) IMMUNOTOXICITYi 1995 Item 107 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** HELD TERMS REVIEH YEAR 2459 GEN PUBLICATION HEPATOTOXICITY OF VINYL CHLORIDE AND 1>1-DICKLOROETHYLENE: ROLE OF MIXED FUNCTION OXIDASE SYSTEM. REYNOLDS ES>NONE(MOSLEM KT,NONEiSZABO $>NONE(JAEGER R,NQNE)MURPHY SD>NONE) UNCNOW) 1975 VCMiVDC(METABOLISM)RATS) HEPATOTOXICITY) 1990 Item 108 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** REVIEW YEAR 2451 GEN REPORT A PROPORTIONAL MORTALITY STUDY OF WORKERS EXPOSED TO VINYL CHLORIDE 1947-74. PASTERNACK BSNONE) UTKNOM 1974 FIRESTONE POTTSTDHN STUDY. VCM)EPIDEMIOLOGY)HUMAN)EFFECTS)CARCINOGENXCITY 1990 Item 109 ACCESSION NUMBER < FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ****** HELD TERMS REVIEH YEAR 244ft. GEN REPORT IMMUNOPATHOLOGIC OBSERVATIONS ZN LIVER ANGIOSARCOMA. ESPINOSA ENONE) IWIV OF LOUISVILLE) 1971 VCM)LIVER)ANGIOSARCOMA)HUMAN)EFFECTS IMUNOLOGIC ) 1990 Item 110 ACCESSION NUMBER 2448 23521036 $ o o i DATA SEARCH ON VCM/TOKICITY STUDIES FOR CRAIG ELGUT Order nurfcer 911001-135640-WIZ -001-007 page 37 set 13 with 374 of 374 items FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS HELD TERMS REVIEW YEAR ***** GEN REPORT EVALUATION OF THE ENVIRONMENTAL TOXICANTS VINYL CHLORIDE (VC) AND VINYLIDENE CHLORIDE. LEE CC> NONE{WINSTON JH*NONEPETERS PJ>NONEBHANDARI JC,N0NE|HODGSON JR*NONEjHAGENSEN JH,N0ME* REDDIG TW*N0NE)ELLIS ERN0NE* NONE*FOR NIEHS) 1977 VCM>VDC>RATSHNHALATION>CHRONIC MIDWEST RESEARCH INSTITUTE* 1990 Item 111 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** REVIEW YEAR 2446 GEN PUBLICATION ANGIOSARCOMA OF THE LIVER IN VINYL CHLORIDE/POLYVINYL CHLORIDE WORKERS. SPIRTAS R,NONEjKAKLNSKI RNONE| J OF OCCUPATIONAL MEDICINE* VOL 20(6) PP.427-429* 1976 VCM * ANGIOSARCOMAlHUMAN *E FFECTS 1990 Item 112 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** HELD TERMS REVIEW YEAR 2445 GEN REPORT TEN CASES OF LIVER ANGIOSARCOMA EXPERIENCED IN WORKERS EXPOSED TO VCM. BERROD J,NONE HAZARD P,NONEPIERRE C,NONE)PUECH AM,NONEtRAVIER E*NONE)RETY J*NONE)SMAGGHE 6,NONE* NONE,AT DUBROVNIK ON 9/26/78* 1978 VCM*HUMAN {EFFECTS*ANGIOSARCOMA 19TH INTERNATIONAL OCCUPATIONAL MEDICINE CONFERENCE) 1990 Item 113 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ****X> HELD TERMS REVIEW YEAR REPORT EPIDEMIOLOGICAL STUDY OF VINYL CHLORIDE WORKERS. NONE,NONE* NONE*FOR CMAl 1976, JANUARY VCM*EPIDEMIOLOGY)HUMAN*EFFECTS*CARCINOGENICITY EQUITABLE ENVIRONMENTAL HEALTH INC* 1990 23521037 B FG 52914 DATA SEARCH ON VCH/TOXICITY STUDIES FOR CRAIG ELGUT Order number 911001-135640-HIZ -001-007 page 36 set 13 with 374 of 374 items Item 114 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS xxxxxxx REVIEN YEAR 2442 GEN REPORT CRITIQUE OF CPSC VCM SINGLE EXPOSURE CANCER BIOASSAY IN RATS AND MICE. TORKELSON TR,DOH CHEMICAL CO) DOH CHEMICAL CO) 1979 VCM)RATS)MICE)INHALATION)CARCINOGENICITY 1990 Item 115 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS xxxxxxx REVIEH YEAR 2441 GEN PUBLICATION MORTALITY EXPERIENCE OF NORKERS IN A VINYL CHLORIDE MONOMER PRODUCTION PLANT. BUFFLER PA*NONE)HOOD S*N0NE)E1FLER C*NQNE)SUAREZ L,NONE LILIAN DJ,NONE> J OF OCCUPATIONAL MEDICINE* V0L2K3) PP. 195-203) 1979 VCM)EPIDEMIOLOGY)CARCXNOGENICXTY)HUMAN)EFFECT5 1990 Item 116 ACCESSION NUT-eER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS xxxxxxx HELD TERMS REVIEH YEAR 2440 GEN PUBLICATION SHORT-TERM INHALATION TOXICITY OF HALOGENATED HYDROCARBONS. JAEGER RJN0NE)C0M40LLY RB*NONE)MURPHY SO*NONE) ARCH ENVIRON HEALTH*VOL 30 PP.26-31) 1975 CARBON TETRACHLORIDE)VCM)INHALATION|RATS)LIVER)EFFECTS)11-DICHLOROETHYLENE) 1*1-OIFLUOROETHYLENE)2-CHLOROBUTADIENE)11-DIBROMOETHYLENE) 1990 Item 117 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 2430 GEN PUBLICATION ANGIOSARCOMA OF THE LIVER: ANNUAL OCCURRENCE AND AETIOLOGY IN GREAT BRITAIN. BAXTER PJ*NONE>ANTHONY PP*NONE)MACSHEEN RNM*NQNE)SCHEUER PJ*NONE) BRITISH J OF INDUSTRIAL MEDICINE,VOL 37 PP.213-221) 1980 THE AWUAL OCCURRENCE OF ANGIOSARCOMA OF THE LIVER IN BRITAIN FROM 1963 TO 1977 NAS STUDIED. 35 CASES MERE CONFIRMED. 8 CASES HERE ATTRIBUTABLE TO THOROTRAST AND 2 TO VCM. ONE CASE APPEARED TO BE ATTRIBUTABLE TO ARSENICAL INTOXICATION. ^^2 vn a\ vO O pa *. W o J ) DATA SEARCH ON VCM/TOX1CXTY STUDIES FOR CRAI6 ELGUT Order runber 911Q01-135640-HIZ -001-007 page 39 set 13 with 374 of 374 itests DESCRIPTORS HELD TERMS REVIEW YEAR xxxxxxx VCM)THORQTRAST)ARSENIC)ANGIOSARCOMA|HUMAN)EFFECTS ARSENICALS) 1991 Item 116 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS xxxxx: REVIEW YEAR 2429 GEN PUBLICATION PROPORTIONAL MORTALITY AMONG VINYL-CHLORIDE WORKERS. MONSON RR,NONE>PETERS JM>NONE)JOHNSON HN,NONE) THE LANCET, PP.397-398) 1974 A PROPORTIONAL MORTALITY STUDY OF 161 VCN WORKERS IS REPORTED. EXCESS CANCERS OF THE LIVER, BILIARY TRACT, LUNG, AND BRAIN HERE NOTED. VCM)HUMAN)EFFECTS)EPXDEMXOLOGY)CARCXNOGENXCXTY 1991 Item 119 ACCESSION NUtBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** HELD TERMS KHIC INDEX NUtBER REVIEW YEAR 2428 GEN PUBLICATION IN VIVO OBSERVATIONS OF SKIN CAPILLARIES IN WORKERS EXPOSED TO VINYL CHLORIDE. MARICQ HR,NQNE)DARKE CSN0NE)ARCHIBALD RMCL,NONE)LEROY EC,NONE) BRITISH J OF INDUSTRIAL HEDXCXNE,VOL 35 NO.l PP.1-7) 1978 VCM-EXPQSED EMPLOYEES FROM A PVC PRODUCTION PLANT IN ENGLAND HERE EXAMINED BY IN VIVO CAPILLARY MICROSCOPY. ABNORMALITIES WERE NOTED. VCM)PVC)IN VIVO)SCLERODERMA) CAPILLARY ABNORMALITIES) 03753 1990 Item 120 ACCESSION NUfBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS xxaxxi HELD TERMS KHIC INDEX NUMBER REVIEW YEAR 2427 GEN PUBLICATION THE BLASTOMOGENIC HAZARD OF VINYL CHLORIDE (A CLINZCO-HYGXENZC AND EPIDEMIOLOGICAL STUDY). FILATOVA VS,NONE) NONE,VOL 1 PP.28-31) 1982 VCM)PVC)HUMAN)EFFECTS)EPXDEMXOLOGY)CARCXNOGENICXTY GIG.TR.PROF.2AB0L.) 05107 1990 Item 121 033 BFG52916 DATA SEARCH ON VCH/TOXICITY STUDIES FOR CRAIG ELGUT Order number 9U001-135640-HIZ -001-007 page 40 set IS with 374 of 374 items ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS xxxxxxx KHIC INDEX NUTOER REVIEW YEAR 2426 GEN REPORT MORTALITY AND CANCER MORBIDITY IN NORKERS IN THE SWEDISH PVC-PROCESSING INDUSTRY HOLFBERG B,NONE)ELOFSSON S>N0NE)H0LMLUND L,NONE)HAASING RN0NE(MOLINA G,NONE>HESTERHOLM P,N0NE) ICI,F0R APME MEETING IN SWEDEN) 1979 VCM)PVC)HUMAN)EFFECTS)EPIDEMlOLOGY (CARCINOGENICITY 05101 1990 Item 122 ACCESSION NUFBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** KHIC INDEX NUMBER REVIEW YEAR 2424 GEN PUBLICATION INVESTIGATION OF THE DISEASES PRODUCED BY VINYL CHLORIDE. SUCIU INONE(DREJMAN I,NONE(VALASKAI M>NONE( MEDXCINA INTERNA (BUCHAREST),VOL 15 PP.967-978) 1963 EFFECTS NOTED: NARCOTIC, EUPHORIA, ANEBRIATION, DYSPEPTIC DISTURBANCES, HEPATOMEGALY, SPLENOMEGALY, ACROOSTEOLYSIS, DERMATITIS, SCLERODERMA. VCM)HUMAN(EFFECTS(ACUTE(CHRONIC(SCLERODERMA(ACROOSTEOLYSIS 05100 1990 Item 123 ACCESSION NUTBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** KHIC INDEX NUtBER REVIEH YEAR 2423 GEN PUBLICATION THE TOXICITY OF VINYL CHLORIDE AS DETERMINED BY REPEATED EXPOSURE OF LABORATORY ANIMALS TORKELSON TR,NONE(OYEN F,NONE(ROHE VK,N0NE( J OF AIHA,VOL 22 NO.5 PP.354-361) 1961 VCM)INHALATION)GUINEA PIGS)RATS)DOGS)RABBITS)CHRONIC)EFFECTS 05099 1990 Item 124 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/A FFILIATION ORIGIN DATE ABSTRACT 2422 GEN PUBLICATION FftJTAGENIC EFFECTS OF VINYL CHLORIDE ON DROSOPHIA MELANOGASTER WITH AND WITHOUT PRETREATMENT KITH SODIUM PHENOBARBITURATE. MAGNUSSON J,NONE)RAMEL C,NONE) MUTATION RESEARCH, VOL 57 PP.307-312) 1978 TREATMENT OF DROSOPHIA MALES WITH 1-20/C VCM IN AIR GAVE AN INCREASED FREQUENCY OF COMPLETE AND 22S21040 oxA o O o a DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order nunber 911001-135640-WIZ -001-007 page 41 set 13 with 374 of 374 items MOSAIC RECESSIVE LETALS. PRETREATMENT WITH PHENOBARBITURATE FOR 24 HR CAUSED AN INCREASE IN THE MUTAGENIC EFFECT OF VCM. THIS INDICATES THAT THE MIXED FUNCTION OXIDASE SYSTEM CAN BE INDUCED IN DROSOPHILA. DESCRIPTORS xxxxxxx VCM)MUTAGENICITY)IN VIVO HELD TERMS DROSOPHILA) KHIC INDEX NUMJER 05097 REVIEW YEAR 1990 Item 125 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS **** HELD TERMS KHIC INDEX NUMBER REVIEW YEAR 2420 GEN PUBLICATION EXPERIMENTAL CHRONIC POISONING WITH VINYL CHLORIDE (MCNOCHLOROETHENE). PRODAN LNONE)SUCIU I,NONE)PISLARU V,NONE)XLEA E,NONE)PASCU LNQNE) ANNALS OF THE NEW YORK ACAOEMY OF SCIENCES,VOL 246 PP.159-163) 1975 VCM EFFECTED GROWTH IN GUINEA PIGS. LESIONS HERE OBSERVED IN THE LIVER KIDNEYS, SPLEEN, AND LUNGS. VITAMIN C REDUCED THE SEVERITY OF THE LESIONS. REVERSIBILITY OF HEPATORENAL LESIONS HERE OBSERVED HHEN EXPOSURE HAS INTERRUPTED. FIBROTIC LESIONS IN THE LUNG HERE OBSERVED. VCM)INHALATXON)GUINEA PXGS)CHRONIC VITAMIN C) 05042 1990 Item 126 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS xxxxx: HELD TERMS KHIC INDEX NUMBER REVIEW YEAR 2419 GEN PUBLICATION EPIDEMIOLOGICAL STUDIES OF VINYL CHLORIDE HEALTH EFFECTS IN THE UNITED STATES. FALK HNONE)MAXHEILER RJ,NONE) NONE,VOL 69 PP.303-305) 1976 VCM)HUMAN)EFFECTS)EPIDEMIOLOGY PROC.ROY.SOC.MED.PROCEEDINGS ROYAL SOCIETY MEDICINE) 05040 1990 Item 127 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS *** HELD TERMS 2417 GEN PUBLICATION CHANGES IN THE ARTERIES IN THE HAND AND FINGERS DUE TO VINYL CHLORIDE EXPOSURE. KOISCHNITZ D,NONE)MARSTELLER HJNONE)LACKNER K,NONE)BRECHT G,N0NE)BRECHT T,N0NE) NONE,VOL 132 N0.1 PP.62-68) 1980 VCM)ACftOOSTEOLYSIS)HUMAN)EFFECTS FORTSCHR GEB RONTGENSTR NUKLEARMED) I ^ 041 <*> qx vn O & DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order ramker 911001--13E640-MIZ -001-007 page 42 set IS with 374 of 374 items KWIC INDEX NUMBER REVIEW YEAR 05007 1990 Item 128 ACCESSION NUMBER 2416 FILE LOCATION GEN DOCUMENT TYPE TITLE OR SUBJECT PUBLICATION ANGIOSARCOMES DU FOIE CHEZ DES OUVRIERS AYANT ETE EN CONTACT PROLONGE AVEC LE CHLORURE DE VINYLE: EP1DEMIOLOGXE ET PROGRAMME DE RESHERCHES CHEZ LES OUVRIERS. AUTHOR/AFFILIATION MAKK L *NONE}DELORME F*NONE}CREECH JL*BFG) ORIGIN NONE,VOL 104 PP.1833-1835} DATE 1975 ABSTRACT ALL OF THE 1183 EMPLOYEES OF ONE OF TWO PLANTS WERE TESTED. THREE NEW CASES OF ANGIOSARCOMA HERE DISCOVERED. DESCRIPTORS xxxmxxx VCM}ANGIOSARCOHA}HUMAN}EFFECTS}EPXDEMIOLOGY HELD TERMS TOME* KWIC INDEX NUMBER 04989 REVIEW YEAR 1990 Item 129 ACCESSION NUMBER 2415 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT CHROMOSOMAL ANALYSES IN VINYL CHLORIDE EXPOSED KPRKERS: RESULTS FROM ANALYSIS 18 AND 42 MONTHS AFTER AN INITIAL SAMPLING. AUTHOR/AFFILIATION ANDERSON D,NONE}RICHARDSON CR*N0NEJWEIGHT TM*NONE}PURCHASE IFH>N0NE}ADAMS HGF>N0NE) ORIGIN MUTATION RESEARCH* VOL 79 PP.151-162} DATE 1980 ABSTRACT THE AUTHORS REPORT THAT A REDUCTION IN EXPOSURE TO VCM HAS ACCOMPANIED 8Y A REDUCTION IN CHROMOSOMAL ABNORMALITIES IN WORKERS TO LEVELS INDISTINGUISHABLE FROM CONTROLS. DESCRIPTORS **xxxxx VCM{HUMAN}EFFECTS}WORKERS}MUTAGENICITY}CHROMOSOMAL ABNORMALITIES)LYMPHOCYTES HELD TERMS CHROMOSOMES} KWIC INDEX NUMBER 04988 REVIEW YEAR 1995 Item 130 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 2413 GEN PUBLICATION NEUROLOGICAL CHANGES IN VINYL CHLORIDE-EXPOSED WORKERS. STIBLOVA V,NQNE}LAfL V,NONECHUMCAL 0*N0NE}KELLER0VA V>NONE}PASKOVA V,NONE|VITOVCOVA J,NONEj ZLAB L*N0NE} NONE*VOL 25 NO.3 PP.233-243} 1981 SOME OF THE NEUROLOGIC MANIFESTATIONS ARE CAUSED BY THE NARCOTIC ACTION OF VCM* SUCH AS CERTAIN SUBJECTIVE COMPLAINTS AND CEREBELLAR AND/OR VESTIBULOCEREBELLAR SYNOROME. THESE SYMPTOMS CAN BE TRANSITORY OR PERSISTENT. CHARACTERISTIC OF VCM ARE PERIPHERAL VASOMOTOR EFFECTS. LESIONS OF THE 22S21042 r-* g\ DATA SEARCH ON VCM/TCXICITY STUDIES FOR CRAIG EL6UT Order nunber 911001-135640-NIZ -001-007 page 43 set 13 with 374 of 374 items DESCRIPTORS ***# HELD TERMS KWIC INDEX NUMBER REVIEW YEAR PERIPHERAL BLOOD VESSELS AND NEURONS HERE NOTED. ABNORMAL EEC NAS DISCUSSED. VCM)ACROOSTEOLYSISJRAYNAUD1S SYNDROME\HUNAN^EFFECTS J OF HYGIENE , EPIDEMIOLOGY ^MICROBIOLOGY IHHMOLOGY j 04983 1990 Item 131 ACCESSION NUt-BER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS *xxxxx KWIC INDEX NUMBER REVIEW YEAR 2412 GEN PUBLICATION MUTAGENICITY AND TERATOGENICITY OF VINYL CHLORIDE MONOMER (VCM). CLEMNESEN J,N0NE) MUTATION RESEARCH, VOL 98 PP.97-100i 1982 VCM)EPIDEMIOLOGY>MUTAGENICITY>TERATOGENICITY)HUMAN>EFFECTS 04982 1990 Item 132 ACCESSION NUMBER 2411 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT CHEMOTHERAPY OF VINYL CHLORIDE-ASSOCIATED HEPATIC ANGIOSARCOMA. AUTHOR/AFFILIATION DANNAHER CL,NONETAhBURRO CH,NONE|YAM LT,N0NE> ORIGIN CANCER, VOL 47 PP.466-49l DATE 1981 ABSTRACT SYSTEMIC CHEMOTHERAPY HAS STUDIED IN A GROUP OF FOUR PATIENTS WHO HAD VCH-ASSOCXATEO ANGIOSARCOMA. FURTHER INFORMATION IS NEEDED FOR SPECIFIC RECOMMENDATIONS, BUT CHEMOTHERAPY DOES APPEAR TO BE OF VALUE. DESCRIPTORS xxxxxxx VCM)ANGIOSARCOMA)HUMAN)EFFECTS)CHEMOTHERAPY KWIC INDEX NUMBER 04981 REVIEW YEAR 1990 Item 133 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS **** KHIC INDEX NUMBER REVIEW YEAR 2410 GEN PUBLICATION CANCER MORTALITY OF A GROUP OF CANADIAN WORKERS EXPOSED TO VINYL CHLORIDE MONOMER. THERIAULT G,NONE*ALLARD P>N0NE* J OF OCCUPATIONAL MEDICINE, VOL 23(10) PP.671-676* 1981 THE MORTALITY OF 451 VCM-EXPOSED WORKERS HAS COMPARED HTXH THAT OF 870 NONEXPOSED WORKERS. THE RELATIVE RISK OF DIGESTIVE CANCER NAS ELEVATED BUT ALSO HIGHER IN THE GENERAL POPULATION. NO OTHER CANCER WAS IN EXCESS. VCM*HUMANjEFFECTSjEPIDEMIOLOGY 04976 1991 U-j ijl 1 DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order nurfcer 911001-135640-MIZ -001-007 page 44 set 13 with 374 of 374 items Item 134 ACCESSION NlltBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** HELD TERMS KHIC INDEX HUBER REVIEW YEAR 2409 GEN PUBLICATION VINYL CHLORIDE MONOMER-INDUCED DISEASE: CLINICA, RADIOLOGICAL AND IfMJNOLOGICAL ASPECTS GRAINGER RG>N0NE*HALKER AE>NONE*HARD AM*NONE) NONE*CHAPTER 11 PP.191-214* 1980 VCM)HUMAN)EFFECTS INDUCED DISEASE:DRUGIRRADIATION*OCCUPATION* 04973 1990 Item 135 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** KHIC INDEX NUMBER REVIEW YEAR 2408 GEN PUBLICATION POWER CONSIDERATIONS IN EPIDEMIOLOGIC STUDIES OF VINYL CHLORIDE WORKERS. BEAUMONT JJ NONE *BRESLOK NE*N0NE* AMERICAN J OF EPIDEMIOLOGY*VOL 114 NO.5 PP.725-734* 1981 WHEN POWER HAS TAKEN INTO CONSIDERATION* THE RESULTS FOR LIVER* LUNG* AND BRAIN CANCER HERE FOUND TO BE CONSISTENT WITH AN ETIOLOGIC ROLE FOR VCN. LUNG CANCER HAS NOT ASSOCIATED WITH VCM. VCM*HUMAN*EFFECTSCARCINOGENICITY*LUNG)BRAIN*LIVER*EPIDEMIOLOGY 04965 1991 Item 136 ACCESSION NUMJER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** HELD TERMS KHIC INDEX NUBER REVIEW YEAR 2407 GEN PUBLICATION ANGIOSARCOMA OF THE PENIS WITH HEPATIC ANGIOMAS IN A PATIENT WITH LOW VINYL CHLORIDE EXPOSURE. GHANDUR-tNAYMNEH L*NONE)GONZALEZ MS*NONE* CANCER* VOL 47 PP.1318-1324* 1981 VCM)ANGIOSARCOMA*BODY PARTS*HU1AN*EFFECTS PENIS* 04960 1991 Item 137 ACCESSION NUMJER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT 2402 GEN PUBLICATION AN EPIDEMIOLOGICAL STUDY OF VINYL CHLORIDE EXPOSED WORKERS IN ITALY. 1 104-* ci % o DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG EL9UT Order number 911001-135640-WIZ -001-007 page 45 set 13 with 37* of 37* items AUTHOR/AFFILIATION BERTZZI PA>NQNE)VILLA A*NONE)FOA V*NONE)SAIA B,NONEvFABBRI L,NQNE)HAPP C,NONE)MARCER C,NCNE> MATMO M,NONE)MARCHI MNONE)MARIANI F*NONE)BOTTASSO F,NONE) ORIGIN NONE>VOL 30 PP.379-397) DATE 1979 ABSTRACT AMONG THE EXPOSED WORKERS WHO HAD DIED* A HIGH PERCENTAGE OF TUMORS AS CAUSE OF DEATH HAS OBSERVED) 30V. WERE OF THE LIVER AND BILIARY SYSTEM. THREE WERE ANGIOSARCOMAS OF THE LIVER. DESCRIPTORS kkkkxkk YCM)PVC)HUMAN)EFFECTS)EPIDEMIOLOGY HELD TERMS ARH.HIG.RADA.TOXSIKOL.) KHIC INDEX NUTCER 0*955 REVIEW YEAR 1991 Item 138 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ******* HELD TERMS KHIC INDEX NUMBER REVIEW YEAR 2*00 GEN PUBLICATION VINYL CHLORIDE MONOMER LEVELS IN EDIBLE FATS. FUCHS G*NONE)GAHELL BM*NONE)ALBANUS L,NONE)SLORACH S*N0NE) NONE,VOL 27 NO.3 PP.13*-145> 1975 METHODS FOR ANALYSIS OF VCM IN EDIBLE FAT. VCM) ANALYSIS)FAT VAR FODA) 0*83* 1990 Item 139 ACCESSION NUhBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ****** KHIC INDEX NUMBER REVIEW YEAR 2399 GEN PUBLICATION CHRONIC TOXIC LIVER DAMAGE IN THE CASE OF WORKERS IN PVC PRODUCTION. MARSTELLER HJ,NONEjLELBACH MC*NONE)MULLER R*NONE)JUHE SNONE)LANGE CE*NONE)ROHNER HG*N0NE) VELTMAN G,NONE DEUTSCH MED WSCHR*VOL 98 PP.2311-231*) 1973 CLINICAL OBSERVATIONS ARE PROVIDED. PVC)VCM)CHRONIC)HUMAN)EFFECTS)LIVER 0*833 1990 Item 1*0 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE 2398 GEN PUBLICATION THE SO-CALLED VINYL CHLORIDE DISEASE. JUHE S,NONE)LANGE CE*NONE)STEIN GNONE)VELTMAN G*NONE) DEUTSCH MED WSCHR,VOL *3 PP.2034-2037) 1973 "1045ryy'r. fJ.*wOA oc\i vn O DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Ordar nunbar 911001-135440-MIZ -001-007 : paga 44 sat 13 with 374 of 374 itsas DESCRIPTORS *** KKXC INDEX NUWER REVIEH YEAR VCM>HUMAN(EFFECTS 04631 1990 Itaa 141 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AF FILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** HELD TERMS KHIC INDEX NUMBER REVIEN YEAR 2397 GEN PUBLICATION VINYL CHLORIDE AND ANGIOSARCOMA. BLOCK JB,NONE( NONE,VOL 72 NO.9 PP.463-486) 1974 CLINICAL AND PATHOLOGICAL FINDINGS ASSOCIATED WITH ANGIOSARCOMA OF THE LIVER ARE DISCUSSED DIAGNOSIS AND TREATMENT ARE CONSIDERED. VCM (ANGIOSARCOMA>HUMAN(EFFECTS(PATHOLOGY J OF THE KENTUCKY MEDICAL ASSOCIATION} 04630 1990 Itaa 142 ACCESSION NLfBER 2394 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT THE VALUE OF PREDICTIVE EXPERIMENTAL ENVIROttENTAL CARCINOGENESIS AN EXAMPLE: VINYL CHLORIDE. AUTHOR/AFFILIATION HALTOKE C,NONE( ORIGIN AHBIO, VOL 4(1) PP.18-23} DATE 1975 ABSTRACT STUDIES SHOH THAT VCM CAUSES CANCER IN RATS, MICE, AND HAMSTERS (ANGIOSARCOMA AM POSSIBLY OTHER TUMORS). DESCRIPTORS wawnnni VCH(CARCXNOGENICXTY}RATS|KICE (HAMSTERS (INHALATION(AN6IQSARCOMA(CHRONXC! EFFECTS KHIC INDEX NUMBER 04626 REVIEN YEAR 1990 Itaa 143 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ******* KHIC INDEX NUTOER REVIEW YEAR 2395 GEN PUBLICATION HEPATIC ANGIOSARCOMA IN A VINYL CHLORIDE WORKER. SMITH PM,NONE (WILLIAMS DHJ,NONE (EVANS DHD,NONE) BULL.N.Y.ACAD.HED.,VOL52 N0.4 PP.447-452( 1974 VCM(ANGIOSARCOMA(HUMAN(FFCTS 04627 1991 i Itaa 144 22521046 J J Q DATA SEARCH ON VCH/TOXXCXTY STUDIES FOR CRAIG ELGUT Order number 911001-135640-WZ -001-007 f peg* 47 Mi 13 with 374 of 374 iiom ' 22521047 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTNOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** KHIC INDEX NUMBER REVXEM YEAR 2394 GEN REPORT NEOPLASTIC RISK AMONG VINYL CHLORIDE POLYMERIZATION WORKERS. HAXHEXLER RJ> NONE (STRINGER H,NONE(FALK H,NONE(CARTER C,NONE(JQNES J ,NONE (WAGONER JK,NGNE( NOtC,PRESENTED AT NYAS CONFERENCE) 1975, MARCH 25 PAPER PRESENTED AT NYAS CONFERENCE ON THE EXCESS CANCER INCIDENCES OF THE BRAIN, LUNG, AND LIVER OBSERVATIONS. VCM>PVC) HUNAN >EFFECTS (CARCINOGENICITY (EPIDEMIOLOGY 04625 1990 BFG 52924 Xiea 145 ACCESSION NUtBER 2393 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT HEHAN6I0SARCGMA OF THE UVER, COttfECTXCUT. AUTHOR/AFFILIATION NONE,NONE) ORIGIN CDC,PUBLIC HEALTH SERVICE EPI-74-104-2) DATE 0% ABSTRACT 1974, OCTOBER 9 FROM JANUARY 1935 THROUGH DECEtBER 1973, B CASES OF ANGIOSARCOMA OF THE LIVER HERE REPORTED TO THE COttlECTICUr TUMOR REGISTRY. DESCRIPTORS ******* ANGXOSARCGHA(VCM(PVC (HUMAN (EFFECTS KHIC INDEX MJMBER 04623 REVZEN YEAR 1991 Itaa 144 ACCESSION NUtBER FILE LOCATION DOCUCNT TYPE TITLE OR SUBJECT Al/THOR/AFFILIATXON ORIGIN DATE ABSTRACT DESCRIPTORS ***** KHIC INDEX NUtBER REVXEM YEAR 2392 GEN PUBLICATION EFFECT OF OCCUPATIONAL AND NONOCCUPATXONAL FACTORS ON THE RESPIRATORY SYSTEM OF VINYL CHLORIDE AND OTHER WORKERS. GAMBLE J,NONE (LIU S NGNE (MCMXCHAEL AJ,NONE|NAXHEXLR RJ,NQNE( J OF OCCUPATIONAL MEDICINE, VOL 16(10) PP.659-470) 1976 VCM HAS NOT ASSOCIATED KITH CHRONIC RESPIRATORY EFFECTS. VCH(PVC|EPIDEMIOLOGY(HUHAN)EFFECT5(LUNG(RESPIRATORY EFFECTS 04618 1990 lias 147 ACCESSION NUtBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT 2391 j GEN PUBLICATION RESOLUTION OF DOSE-RESPONSE TOXICITY DATA FOR CHEMICALS REQUIRING METABOLIC ACTIVATION EXAMPLE-VINYL CHLORIDE. DATA SEARCH OH VCM/TOKICXTY STUDIES FOR CRAIG ELGU? Onfor madbcr 911001-135640-MIZ -001-007 pmgm 4S --i IS frith $74 of 374 itw 22521043 AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS WWW KHXC INDEX NUMBER REVIEH YEAR GEHRXNG PJ>D0H CHEMICAL CO)NATANABE PG.SAME)PARK CN.SAME) TOXICOLOGY AND APPUED PHARMACOLOGY. VOL 44 PP,E81-591> 1978 ASSUMING NO THRESHOLD IN SPITE OF EVIDENCE TO THE CONTRARY. EXTRAPOLATION OF THE DATA BELOW THE RANGE OF DOSES CAUSING EXPERIMENTALLY OBSERVABLE RESPONSES PREDICTED AN INCIDENCE OF 0.01Z HEPATIC ANGIOSARCOMA IN THE RATS EXPOSED TO 4.6 PPM OF VCH. THEORETICAL EXTENSION OF THE EXTRAPOLATION TO HUMANS AFTER ADJUSTING FOR METABOLIC AND BODY MASS DIFFERENCES HAS UNDERTAKEN. THE THEORETICAL EXTRAPOLATION FOR MAN EXPOSED DAILY FOR 8 HR TO 1 PPM SUGGESTS AN INCIDENCE OF 1.5 PER 100,000,000. THIS THEORETICAL INCIDENCE, ALTHOUGH A LIKELY OVERESTIMATE BECAUSE OF A LESS THAN PREDICTED INCIDENCE IN MEN EXPOSED TO 200 PPM AND GREATER, AS NELL AS EVIDENCE FOR A THRESHOLD IN RATS, IS LESS THAN THAT EXPECTED TO OCCURR SPONTANEOUSLY. VCM)RATS)HUHAN)PHARMACOKINETICS)CARCINOGENICITY)XNCIDENCE) 04816 1990 's % O XtM 148 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE abstract DESCRIPTORS ***** KMXC INDEX NUMBER REVIEW YEAR I\m 149 2390 GEN PUBLICATION CHARACTERISTICS OF CASES OF ANGIOSARCOMA OF THE LIVER AMONG VINYL CHLORIDE WORKERS IN THE UNITED STATES. HEATH CH,CDC>FALK H.CDClCREECH JL,BFG> ANULS OF THE NEW YORK ACADEMY OF SCIENCES,VOL 246 PP.231-236) 197B A TOTAL OF 13 CASES OF ASL HAVE BEEN DOCUMENTED AMONG VCH WORKERS. AVERAGE LATENCY HAS 20.3 YRS. VCH>PVCHUMAN>EFFECTS>EPXDEMXOLOGY 04815 1991 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT M/THOR/AFFXLIATXOH 2389 GEN PUBLICATION MORTALITY EXPERIENCE OF A COHORT OF VINYL CHLORIDE-POLYVINYL CHLORIDE WORKERS. NICHOLSON HJ.NONE)HMWND EC.NONE>SEIDMAN H.NONEiSELZKOFF XJ.NQNE) MRIS OF THE ICN YORK ACADEMY OF SCXENCES.VOL 244 PP.225-230) DATA ARE DERIVED FROM EARLY FOLLON-UP OF INDIVIDUALS EXPOSEO FOR 5 OR MORE YEARS TO VCH IN r AmiMBUZATnN FACILITY. AT LEAST 17% OF THE DEATHS THAT OCCURRED HERE CAUSALLY RELATED TO tiraUMTD VCH. UMBER PERIODS OF OBSERVATION ARE REQUIRED TO PROVXOE INFORMATION CONCERNING THE fOUSiPECTRUM OF VCH-XNDUCED MALIGNANCIES AND THEIR INCIDENCE AMONG EXPOSED WORKERS. VCmpVC)WJHAM)EFFECTS)EPZDEHI0L06Y ? ggf? i tffyfyyw NUMBER 2388 DATA SEARCH ON VCh/TOXICXTY STUDIES FOR CRAX6 ELO/T Order nmbw 911001-135640-NIZ >001-007 page 49 Mt 13 Kith 374 of 374 item FILE LOCATION OEM DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT ANGIOSARCOMA OF THE LIVER IN THE MANUFACTURE OF POLYVINYL CHLORIDE AUTHOR/AFFILIATION CREECH JL*BFG)JOHNSONtt4>BFG) ORIGIN J OF OCCUPATIONALMEDICINE* VOL 16(3) PP. 150-151) DATE ABSTRACT 1974 THREE REPORTED CASES OF ANGIOSARCOMA OF THE LIVER SERVE AS AN ALERT TO THE PROBABILITY THAT THIS CONDITION MAY* IN SOME INSTANCES* BE CAUSALLY RELATED TO EMPLOYMENT IN THE MAMJFACTURE OF POLYVINYL CHLORIDE RESINS. DESCRIPTORS mhmmwkm VCM>PVC)ANGIOSARCOHA)HUMAN|EFFECTS)EPIDEMIOLOGY KKXC INDEX NUIBER 04811 REVXEH YEAR 1991 I*M 151 ACCESSION IOBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHDR/AFFXLIATION ORIGIN DATE ABSTRACT DESCRIPTORS whhhh HELD TERMS KHXC INDEX NUIBER REVXEH YEAR 2387 GEN PUBLICATION CLINICAL AND MORPHOLOGICAL FEATURES OF HEPATIC ANGIOSARCOMA IN VINYL CHLORIDE WORKERS, MARK LNONE)DELORHE FN0NEiCREECH JL*NONE)OGDEN LL*NONE)FADELL EK*NONE)SONGSTER CL*N0NE)CLANTON J*N0NE)J0HNS0N m,NONE)CHRXSTDPHERSON W*N0NE) CANCER* VOL 37(1) PP.149-163) 1976 FIFTEEN HALE WORKERS EXPOSED TO VCM DEVELOPED ANGIOSARCOMA OF THE LIVER. VCM)AN6XQSARCOMA)HUMAN)EFFECTS)EPXDEMXOLOGY) HEPATOMEGALY )SPLENOMEGALY ) 04810 1991 Itea 152 ACCESSION NUMBER 2386 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT ANGIOSARCOMA OF THE LIVER FOLLOWING VINYL CHLORIDE EXPOSURE. AUTHOR/AFFILIATION BLOCK JB*NQNE) ORIGIN JAMA* VOL 229 PP.53-54) DATE 1974 ABSTRACT ANGIOSARCOMA OF THE LIVER IS REPORTED IN SIX VCM-EXPOSED WORKERS. DESCRIPTORS ******* VCM)AN6IOSARCOMA)HUHAN)EFFECT$) LIVER KKXC DOEX NUBER 04809 REVXEH YEAR 1990 X4b 153 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION GQ4 PUBLICATION MONITORING LIVER DISORDERS IN VINYL CHLORIDE MONOMER WORKERS USING GREYSCALE ULTRASONOGRAPHY. KILLIANS DHJ*NONE)SMmt PH*NQNE)TAYLOR KJH*NONE)CROSSLEY XR*N0NE)0UCK BM*N0NE) 22521043 C\ \n O DATA SEARCH OH VCH/TOXICITY STUDIES FOR CRAIG ELGL#T Order nunber 911001-135640-*OZ -001-007 ' paga 50 set 13 with 374 of 374 iteon 22521050 ORIGIN OATE ABSTRACT DESCRIPTORS ihhhhhhi KMC INDEX NUfBER REVIEW YEAR BRITISH J OF INDUSTRIAL MEDICINE,V0l 33 PP.152-157) 1976 ULTRASONOGRAPHY SKOHS SOME ADVANTAGES. VCM)PVC)HUHAN)EFFECTS)DETERfflNATXONCARCINOGENICITY*LIVER 04794 1990 Itaw 154 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS *** KNIC INDEX NUMBER REVIEW YEAR 2364 GEN PUBLICATION BREAST CANCER MORTALITY AMONG PVC FABRICATORS. CHIAZZE L*NONE)HONG 0>NONE) NICHOLS KE*NONE) FERENCE LD,NONE) J OF OCCUPATIONAL MEDICINE* VOL 22(10) PP.677-679* 1960 A CASE-CONTROL ANALYSIS OF BREAST CANCER DEATHS AMONG PVC FABRICATORS IS PRESENTED. THIS STUDY IS AN EXTENSION OF A CROSS-SECTIONAL MORTALITY STUDY OF DEATHS OCCURRING AMONG 17 PVC FABRICATORS (1964 TO 1973). RELATIVE RISK ESTIMATES HERE DERIVED AND TESTED. ALTHOUGH NO STATISTICALLY SIGNIFICANT RELATIVE RISKS HERE FOUND* A LEAST SIGNIFICANT RELATIVE RISK MOULD HAVE TO BE ON THE ORDER OF THREE TO ONE IN OROER TO BE DETECTED. THERE DOES SEEM TO BE REASONABLE ASSURANCE THAT VERY LARGE INCREASES IN RISK FOR BREAST CANCER DO NOT EXIST AMONG THESE PVC FABRICATORS. PVC)VCM)CARCIN0GENICITY>HUHAN)EFF6CTS)BREAST|CANCER)EPIDEHI0L0GY 04783 1991 1 I tea 155 % ACCESSION NUttER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS mmmkw HELD TERMS KMC INDEX NUMBER REVIEW YEAR 2383 GEN REPORT REPORT ON MR. JOHN GRASSO. EPSTEIN SSyNONE) NONE,BY SAMUEL S. EPSTEIN) 1980 TESTIMONY IN GRASSO VS BFQ VCM)ANGIOSARCOMA) LITIGATION) 04723 1990 ItM 156 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN 2382 GEN PUBLICATION i COMPARATIVE MAMALIAN METABOLISM OF VINYL AND VZNYLIDENE CHLORIDES IN RELATION TO ONCOGENIC POTENTIAL. HATHMAY DENQNE) ENVIRONMENTAL HEALTH PERSPECTTVES*VOL 21 PP.55-59) J J o o DATA SEARCH ON VCM/70XICITY STUDIES FOR CRAIG ELGUT Order member 911001-135640-WIZ -001-007 page 1 set 13 with 374 of 374 items DATE DESCRIPTORS xxxx: KHIC INDEX NUMBER REVIEW YEAR 1977 VCM)METABOLISM 04718 1990 Item 157 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** HELD TERMS KHIC INDEX NUMBER REVIEW YEAR 2381 GEN PUBLICATION THE CHEMISTRY AND BIOGENESIS OF THE S-CONTAINING METABOLITES OF VINYL CHLORIDE IN RATS. GREEN TNONE)HATHWAY DE,N0NE> NONE,VOL 17 PP.137-1501 1977 ADMINISTRATION OF SEVERAL VCM METABLOITES AND CLOSELY RELATED COMPOUNDS TO RATS SHOWS THAT CHLOROACETALDEHYDE AND S-(CARBOXYMETHYL)-CYSTEINE> BUT NOT CHLOROACETIC ACID, LIE ON A PATHWAY OR PATHWAYS CONNECTING VCM WITH THIODIGLYCOLLIC ACID. VCM)ORAL)METABOLISM)RATS CHEMICAL-BIOLOGICAL INTERACTIONS) 04717 1990 Item 158 ACCESSION NUMBER 2380 FILE LOCATION GEN DOCUMENT TYPE REPORT TITLE OR SUBJECT THE REGULATION OF VINYL CHLORIDE i A CASE STUDY OF THE IMPACT AND IMPLICATIONS OF THE OCCUPATIONAL SAFETY AND HEALTH ACT OF 1970. AUTHOR/AFFILIATION OUTLAW RCNONE)PERRY QRN0NE) ORIGIN NONE) DATE 1977 DESCRIPTORS xxxxxxx VCM)OSHA)ANALYSIS) HELD TERMS UNIV OF PENNSYLVANIA) KHIC INDEX NUfBER 04707 REVIEW YEAR 1990 Item 159 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS 2379 GEN PUBLICATION EFFECTS OF VINYL CHLORIDE EXPOSURE ALONE AND IN COMBINATION KITH TRYPAN BLUE-APPLIED SYSTEMATICALLY DURING ALL THIRDS OF PREGNANCY ON THE FETUSES OF CFY RATS. UNGVARY 6Y,NONE)HUDAK A>N0NE)TATRAI E,NONE)LORINCZ M,NONE)FOLLY G>NONE) NONE,VOL 11 PP.45-54) 1978 VCM WAS FOUND TO CROSS THE PLACENTAL BARRIER. NO TERATOGENIC EFFECT HAS FOUN IN RATS. FETAL MORTALITY AND EMBRYOTOXICITY HERE ONLY OBSERVED DURING THE FIRST TRIMESTER. VCM)RATS)TERATOGENICITY>FETAL TOXICITY)EMBRYOTOXICITY) INCREASED 22531' oo 0\ \n O DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order number 911001-135640-HIZ -001-007 page 52 set 13 with 374 of 374 items AJ HELD TERMS KHIC INDEX NUtDER REVIEW YEAR TOXICOLOGY ^PLACENTAL TRANSFER) 04706 1990 Item 160 ACCESSION NUMBER 2377 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT MORTALITY EXPERIENCE OF WORKERS EXPOSED TO VINYL CHLORIDE MONOMER IN THE MANUFACTURE OF POLYVINYL CHLORIDE IN GREAT BRITAIN. AUTHOR/AFFILIATION FOX AJ>NONE)COLLIER PFNQNE> ORIGIN BJIM> VOL 34 PP.1-10) DATE 1977 ABSTRACT IN A STUDY OF 7000 PVC POLYMERIZATION WORKERS FOUR CASES OF LIVER CANCER WAS FOUND. TWO HERE ANGIOSARCOMAS. ONLY LIVER CANCERS HERE ASSOCIATED WITH EXPOSURE TO VCM. THE TWO CASES OF ANGIOSARCOMA HERE IN MEN WHO HAD BEEN EXPOSED TO HIGH CONCENTRATIONS OF VCM. DESCRIPTORS xxxxxxx VCM)ANGIOSARCOMA)EPIDEKIOLOGY)LIVER)CANCER)HU1AN)EFFECTS KHIC INDEX NUMBER 04646 REVIEH YEAR 1990 Item 161 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** HELD TERMS KWIC INDEX NUTOER REVIEH YEAR 2376 GEN PUBLICATION INDUCTION OF GENE MUTATIONS AND GENE CONVERSIONS BY VINYL CHLORIDE METABOLITES IN YEAST. LOPRIENO N,NONEJBARALE RNONE)BARONCELLI S,NQNE)BARTSCH HN0NE)BRONZETTI 6>N0NE)CAMMELLINI C, NONE)CORSI C,NONE)FREZZA D>N0NE)NIERI R>N0NE)LEPORINI C,NONE)ROSELLINI D,NONE)ROSSI AM,NONE) CANCER RESEARCH> VOL 36 PP.253-257) 1977 CHLOROETHYLENE OXIDE INDUCED FORWARD MUTATION IN SCH. POTOE AND GENE REVERSION IN S. CEREVISIAE. 2-CHLOROACETALDEHYDE SHOWED ONLY FEEBLE GENETIC ACTIVITY. 2-CHLOROETHANOL MAS COMPLETELY INACTIVE. VCM)MUTAGENICITY)CHLOROETHYLENE OXIDE)2-CHLOROACETALDEHYDE) 2-CHLOROETHANOL)YEAST) 04645 1990 Item 162 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** HELD TERMS 2375 REPORT VINYL CHLORIDE, BIRTH DEFECTS, AND FETAL WASTAGE: A CRITICAL REVIEH. DOWNS TD,NONE)$TALLONES RA,NONE)FRAMtOHSKI RF,NONE)LABARTHE DR,NONE) NONE) 1977 VCM)REPRODUCTION)BIRTH DEFECTS)TERATOLOGY)FETAL TOXICITY)HUMAN)EFFECTS SPI)SOCIETY OF PLASTICS INDUSTRY) /G BFG52929 i DATA SEARCH ON VCM/TOXZCITY STUDIES FOR CRAIG ELGUT Order ruifcer 911001-135640-HIZ -001-007 page 53 set 13 with 374 of 374 items KHIC INDEX NUMBER REVIEW YEAR 04588 1990 Item 163 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS **** HELD TERMS KHIC INDEX NUtttER REVIEW YEAR 2374 GEN REPORT TOXICOLOGY* CARCINOGENICITY AND REPRODUCTIVE EFFECTS OF SINGLE AND MULTIPLE EXPOSURES TO VINYL CHLORIDE IN RATS AND MICE. HEHIR RM NONE *MCNAMARA BP >NONE (MCLAUGHLIN J*NONE}HILLIGANDA*NONE}BIERBOHER G*NONE>HARDISTY JF* NONE} NONE} 1960 AUTHORS REPORTED AN INCREASED INCIDENCE OF PULMONARY ADENOMAS AND CARCINOMAS IN MICE EXPOSED TO 5000 AND 50*000 PPM VCM FOR ONE HOUR. ANIMALS NERE EXPOSED THEN HELD FOR ONE 16-24 MONTHS. NO TUMORIGENIC RESPONSE HAS OBSERVED IN RATS. VCM(INHALATIONjDOSE EFFECTS(CARCINOGENICITY(MICE(RATS(ADENOMA(CARCINOMA} PULMONARY ADENOMAS} CPSC} 04576 1990 Item 164 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/A F FILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** HELD TERMS KHIC INDEX NUMBER REVIEW YEAR 2371 GEN PUBLICATION COMPARISONM OF THE FATE OF VINYL CHLORIDE FOLLOWING SINGLE AND REPEATED EXPOSURE IN RATS HATANABE PG.DOH CHEMICAL CO(ZEMPEL JA*SAME(6EHRING PJ,SAME( TOXICOLOGY AND APPLIED PHARMACOLOGY* VOL 44 PP.391-399} 1978 COVALENT BINDING TO MACROMOLECULES NOTED. VCM(METABOLISM(INHALATION(SUBCHRONIC(COVALENT BINDING} MACROMOLECULES} 04321 1990 Item 165 ACCESSION NUTBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** KHIC INDEX NUfBER 2370 GEN PUBLICATION CHROMOSOMAL ANALYSES IN VINYL CHLORIDE-EXPOSED WORKERS. PURCHASE IFHICI(RICHARDSON CR*ICI}ANDERSON DICI(PADDLE GM*ICX}ADAMS HGF*ICI( MUTATION RESEARCH* VOL 57 PP.325-334} 1978 THERE HAS A SIGNIFICANT INCREASE IN CHROMOSOMAL ABNORMALITIES IN THE EXPOSED WORKERS WHEN COMPARED TO CONTROLS. VCM(WORKERS(HUMANiEFFECTS(CHROMOSOMAL ABERRATION(MUTAGENICITY 04320 ^G 52930 09*:? 1053 -J .J w> sj ) sj o DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order ncmber 911001-135640-WIZ -001-007 page 54 set 13 with 374 of 374 items REVIEW YEAR 1990 Item 166 ACCESSION MJMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN OATE ABSTRACT DESCRIPTORS ****) HELD TERMS KWIC INDEX NUTBER REVIEW YEAR 2369 GEN PUBLICATION HEPATO-SPLENIC ANGIOSARCOMA: PRESENTATION OF A REVIEW OF THE LITERATURE. LIBESKIND M,NONE)LUGAGNE F,NONE|KALBRAN JNONE)VILLEMANT J-F ,N0NE {GUYET-ROUSSET P,N0NE{ NONE,VOL.1 PP.1027-1034) 1977 THE AUTHORS REPORT THE CASE OF AN ADULT PATIENT WITH ANGIOSARCOMA OF THE LIVER AND SPLEEN. FROM THIS OBSERVATION AND THE OTHER REPORTED CASES (ABOUT 150) IN THE LITERATURE, THE AUTHORS DELIEATE THE CLINICAL FEATURES AND THE COUSE OF THIS TUMOR. VCM HAS REPORTED AS THE CAUSE IN MOST CASES BUT NOT THIS REPORTED CASE. VCM|ANGIOSARCOMA)HUMAN )EFFECTS{LIVER GASTROENTEROLOGY CLINICAL BIOLOGY* 04318 1990 Item 167 ACCESSION NUtBER 2368 FILE LOCATION GEN DOCUMENT TYPE REPORT TITLE OR SUBJECT LUNG CANCER AT A POLYVINYL CHLORIDE (PVC) POLYMERIZATION FACILITY. AUTHOR/AFFILIATION FALK H,NONE)HAXHILER RJ,NONE {HERBERT J,N0NE )KUSCHNER M,NONE {AUERBACH 0,N0NE{MAKK L,N0NE {TAFBURO C,NONE{ ORIGIN NONE,NONE DATE c ABSTRACT 1979 PVC IS SUGGESTED AS A POSSIBLE ETIOLOGICAL AGENT OF LUNG CANCER. DESCRIPTORS ***** PVC{LUNG*CARCINOGENICITY {HUMAN {EFFECTSVCM{EPIDEMIOLOGY KWIC INDEX NUTOER 04163 REVIEW YEAR 1990 Item 168 ACCESSION NUMBER 2367 FILE LOCATION GEN DOCUMENT TYPE REPORT TITLE OR SUBJECT AN EPIDEMIOLOGIC INVESTIGATION OF AN EXCESS LUNG CANCER RISK IN A SYNTHETIC CHEMICALS PLANT. AUTHOR/AFFILIATION KAXHEILER RJ,NIOSH}SMITH AH,UNIV OF NORTH CAROLXNA{TYROLER HA,SAME{FALK H,NXOSH{ ORIGIN NONE,DUBROVNIK YUGOSLAVIA; DATE 1978 ABSTRACT AN EXCESS LUNG CANCER RISK HAS OBSERVED IN A COHORT OF 4984 MALES EMPLOYED AT A SYNTHETIC CHEMICALS PLANT. PVC HAS SUGGESTED AS THE POSSIBLE ETIOLOGICAL AGENT. DESCRIPTORS xxxxxxx PVC {VCM {LUNG {CARCINOGENICITY {EPIDEMIOLOGY{HUMAN {EFFECTS HELD TERMS XIX INTERNATIONAL CONGRESS ON OCCUPATIONAL HEALTH > KHIC INDEX NUMBER 04162 REVIEW YEAR 1991 DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order nunber 911001-135640-HIZ -001-007 page 55 set 13 with 374 of 374 items 212521055 #FG 52932 Item 169 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS **** HELD TERMS KWIC INDEX NUMBER REVIEW YEAR Item 170 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** KWIC INDEX NUMBER REVIEW YEAR Item 171 ACCESSION NUT-SER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** HELD TERMS KWIC INDEX NUM3ER REVIEW YEAR Item 172 ACCESSION NUMBER 2366 GEN PUBLICATION DEVELOPMENT OF HEPATIC ANGIOSARCOMA IN MAN INDUCED BY VINYL CHLORIDE* THOROTRAST, AND ARSENIC. POPPER H>NONEiTHOMAS LB,NONETELLES NC,NONE)FALK H *N0NE)SELIK0FF IJ>N0NE) N0NE>V0L.92 NO.2 PP.349-370) 1978 EXAMPLES OF HUMAN ANGIOSARCOMA FOLLQHING EXPOSURE TO VCM, THOROTRAST* OR ARSENIC AND CASE* INCLUDING CHILDREN* OF UNKNOWN ETIOLOGY MERE STUDIED TO ESTABLISH DIAGNOSTIC CRITERIA AND TO STUDY THEIR EVOLUTION. VCM)THOROTRAST)ARSENIC)ANGIOSARCOMA)HUMANjEFFECTS AMERICAN J OF PATHOLOGY) 04146 1991 2365 GEN PUBLICATION EPIDEMIOLOGICAL STUDY OF THE MORTALITY OF WORKERS EXPOSED TO VINYL CHLORIDE JVC) IN THE FRG. REINL H*NONE>HEBER H*NONE)GREISER E.NONE) UNKNOWN 1977 GERMAN EPIDEMIOLOGY STUDY SHOWS SIGNIFICANTLY ELEVATED SNR'S FOR MANY DISEASES INCLUDING STOMACH* LIVER* LYMPH SYSTEM AND BLOOD. VCM)HUMAN)E FFECTS >CHRONIC)CARCINOGENICITY 04145 1991 2364 GEN PUBLICATION FATE OF 14C-VINYL CHLORIDE FOLLOWING INHALATION EXPOSURE IN RATS. HATANABE PS,DOW CHEMICAL CO)MCGOHEN GR*SAME)MADRID EO*SAME)GEHRING PJ*SAME)SAME TOXICOLOGY AND APPLIED PHARMACOLOGY* VOL 37 PP.49-59) 1976 VCMjMETABOLISM)INHALATION)RATS)DISPOSITION) METABOLIC FATE DISTRIBUTION) 04125 1990 2361 DATA SEARCH ON YCM/TOXICITY STUDIES FOR CRAIG ELGUT Order ntmfeer 911001-135640-HIZ -001-007 page 56 set 13 with 374 of 374 items FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS **** KHIC INDEX NUMBER REVIEH YEAR GEN PUBLICATION EXPERIMENTAL STUDIES ON THE CHRONIC TOXIC EFFECTS OF VINYL CHLORIDE IN RATS. SOKAL JA,NONEBARANSKI B,NONE*MAJKA J,NONE*ROLECKI RNONEjMATYCH S,NQNEOLCZAK G,NONE*PALUS J, NONE jSTETKIEHICZ JNONE*STETKIEHICZ I>N0NE jHROBLEHSKA K,NONEi UNKNOWN, PP.539* 1970 EXPOSURE OF RATS TO LEVELS OF VCM AS HIGH AS 20,000 PPM FOR 10 MONTHS RESLTED IN BODY NT DEPRESSION, ORGAN HEIGHT INCREASES, BLOOD CHEMISTRY CHANGES, AND MORPHOLOGICAL CHANGES IN THE LIVER. VCM*CHRONIC)INHALATION>RATS 04053 1990 Item 173 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** KHIC INDEX NUMBER REVIEH YEAR 2360 GEN PUBLICATION ANGIOSARCOMA OF THE LIVER IN PVC FABRICATORS. BAXTER PJ,NONE*FOX AJ,NONE> THE LANCET, PP.245-246* 1976, JANUARY 31 VCM*PVCHUMAN*EFFECTS*ANGIOSARCOHA)EP10EMIOLOGY 04020 1991 Item 174 ACCESSION NUMBER 2359 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT CONGENITAL CENTRAL NERVOUS SYSTEM MALFORMATIONS AND VINYL CHLORIDE MONOMER EXPOSURE: A COFWUNITY STUDY. AUTHOR/AFFILIATION EDMONDS LD,NONE*ANDERSON CENONE*FLYNT JH,NONE*JAMES LM,NONE* ORIGIN TERATOLOGY ,VOL 17 PP.137-142* DATE 1978 ABSTRACT INCIDENCE RATES FOR CHS MALFORMATIONS IN INFANTS BORN IN KANANHA COUNTY, NEST VIRGINIA, 1970-1974, HERE SIGNIFICANTLY HIGHER THAN COMPARABLE US RATES. NO RELATIONSHIP NITH PVC MANUFACTURE HAS FOUND. DESCRIPTORS xxxxxxx VCMjBIRTH DEFECTSTERATOGENIC1TY)HUMAN*EFFECTS>EPIDEMIOLOGY KHIC INDEX NUMBER 04004 REVIEH YEAR 1990 Item 175 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT 2358 GEN PUBLICATION A STATISTICAL ASSESSMENT OF THE QUANTITATIVE UPTAKE OF VINYL CHLORIDE MONOMER FROM AQUEOUS o\ \T> O DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order r**>er 911001-135640-NIZ -001-007 page 57 set 13 with 374 of 374 items AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS **** KWIC INDEX NUMBER REVIEW YEAR SOLUTION. HITHEY JR,NONE)COLLINS BTNONEj J OF TOXICOLOGY AND ENVIRONMENTAL HEALTH,VOL.2 PP.311-321} 1976 IT HAS CONCLUDED THAT IF THE TOTAL DAILY LIQUID INTAKE CONTAINED 20 PPM OF VCM THEN THE AREA GENERATED UNDER THE BLOOD LEVEL-TIME CURVE, FOR RATS, WOULD BE EQUIVALENT TO AN INHALATION EXPOSURE OF ABOUT 2 PPM FOR 24-HR. VCM >ANALYSISi RISK ASSESSMENT jDRlNdNG HATER 03995 1991 Item 176 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** KWIC INDEX NUfBER REVIEW YEAR 2356 GEN PUBLICATION PULMONARY TUMORS INDUCED IN MICE BY VINYL CHLORIDE MONOMER. SUZUKI YNONE) ENVIRONMENTAL RESEARCH, VOL 16 PP.285-301> 1978 NEOPLASTIC EFFECTS OF VCM HERE STUDIED IN LUNGS OF 27 MICE EXPOSED TO VCM AT 2500 AND 6000 PPM FOR 5 AND 6 MONTHS. PULMONARY TUMARS WERE OBSERVED IN 26 OF 27 EXPERIMENTAL ANIMALS. VCM INHALATION>CHRONIC)CARCIMOGENICITY}MICEj LUNGS jTUMORS 03959 1990 Item 177 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS **** KWIC INDEX NUTOER REVIEW YEAR 2355 GEN REPORT SUMMARY OF THE STUDIES CONDUCTED ON THE PHARMACOKINETICS/METABOLISM OF VINYL CHLORIDE IN RATS. NATANABE PG,DOH CHEMICAL C0)HEFNER RE>SAME>ZEMPEL JA,SAME)PEGG DG,SAME(PARK CN,SAME(GEHRING PJ, SAME) DON CHEMICAL CO,TO CMA) 1977, MAY 31 PRELIMINARY STUDIES ON THE FATE OF INHALED VCM INDICATED TWO IMPORTANT POINTS: 1) VCM HAS METABOLIZED EXTENSIVELY IN VIVO AND 2) THE METABOLISM OF VCM HAS SATURATED AT HIGH EXPOSURE CONCENTRATIONS. VCM>METABOLISM)RATS>PHARMACOKINETICS 03940 1990 Item 17B ACCESSION NUFBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION 2354 GEN PUBLICATION URINARY GLYCOSAMINOGLYCAN PATTERNS IN ANGIOSARCOMA OF THE LIVER. CURRAN KLUNIV OF LOUISVILLEiKUPCHELLA CE SAMEITAMBURRO CH SAME) A'Z*'7 <!r o\ O DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order jxmfeer 911001-135640-HIZ -001-007 pegs 58 set 13 with 374 of 374 items ORIGIN DATE ABSTRACT DESCRIPTORS **** KHIC INDEX NUMBER REVIEW YEAR CANCER* VOL 40 PP.3050-3053* 1977 GLYCOSAMINOGLYCANS EXTRACTED FROM 24-HOUR URINE SOECIHENS FROM PATIENTS KITH HEPATIC ANGIOSARCOMA AND FROM NORMAL CONTROLS HERE SEPARATED AS CETYLPYRIOINIIM COMPLEXES INTO HYLURONIC ACID, CHONOROITIN SULFATE, AND HEPARIN FRACTIONS, THEN FURTHER SEPARATED AND CHARACTERIZED. THE CHROMATOGRAPHIC PATTERN OF THE URINARY CHQNDRQITXN SULFATE FRACTION IN PATIENTS WITH ANGIOSARCOMA OF THE LIVER DIFFERED FROM THOSE OF THE CONTROLS IN THATTHERE HAS A RELATIVE INCREASE IN THE TOTAL AMOUNT OF URONIC ACID IN A HYALURONADASE-RESISTANTFRACTION AND A DECREASE IN A FRACTION SUSEPTIBLE TO HYALURONXDASE DIGESTION. VCM*ANGIOSARCOMA 03938 1990 Item 179 ACCESSION NUMBER 2353 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT THE EFFECTS OF MATERNALLY INHALEDVINYLCHLORIDE ON EtoRYONAL AND FETAL DEVELOPMENT ZN MICE, RATS, AND RABBITS. AUTHOR/AFFILIATION JOHN JA,DOH CHEMICAL COtSMITH FA>SAME*LE0N6 BKJ,SAME*SCHHETZ BA,SAME* ORIGIN TOXICOLOGY AND APPLIEDPHARMACOLOGY, VOL 39(3)PP.497513* DATE 1977 ABSTRACT NO EMBRYO OR FETAL TOXICITY NOR TERATOGENIC EFFECTS HERE OBSERVEO IN MICE, RATS, AND RABBITS EXPOSED TO VCM VIA INHALATION. ETHANOL XNHANCED TOXICITY. DESCRIPTORS xx-xxxxx VCM*RATS *MICE * RABBITSiTERATOGENICITY * FETAL TOXICITY*INHALATION KHIC INDEX NUMBER 03901 REVIEW YEAR 1990 Item 180 ACCESSION NUMBER 2352 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT ANGIOSARCOMA OF THE LIVER: AN EPIDEMIOLOGY SURVEY. AUTHOR/AFFILIATION BRADY J,NONE*LIBERATORE F,NONE*HARPER P,N0NE*GRENHALD P,NONE*BURNETT H,N0NE*DAVIES JNP,N0NE* BISHOP MN0NE*P0LAN A,NONE*VIANNA N,NONE* ORIGIN J OF NCI,VOL 59 NO.5 PP.1383-1385* DATE 1977 ABSTRACT FROM 1970 TO 1975 THE ANNUAL INCIDENCE RATE FOR ANGIOSARCOMA OF THE LIVER AMONG RESIDENTS OF NEH YORK STATE (EXCLUDING NYC) HAS 0.25 PER MILLION. A CAS-CONTROL STUDY INDICATED THAT DIRECT EXPOSURE TO ARSENIC, VCM, AND THORIUM DIOXIDE HAS A SIGNIFICANTLY IMPORTANT FACTOR IN THE ETIOLOGY OF THIS DISEASE. DIRECT EXPOSURE TO THESE CHEMICALS COULD NOT BE DEMONSTRATED FOR 19 OF THE 26 PATIENTS. THE FACT THAT 5 OF THESE PATIENTS LIVED NEARER TO VCM FABRICATION OR POLYMERIZATION PLANTS THAN DID THEIR MATCHING CONTROLS LENT SOME SUPPORT TO THE HYPOTHESIS THAT INDIRECT MODES OF EXPOSURE, NOT SPECIFICALLY RELATED TO OCCUPATION, MIGHT BE IMPORTANT ETIOLOGICALLY. DESCRIPTORS xxxxxxx VCM*THOROTRAST*ARSENIC*HUMAN*EFFECTS*EPIDEMIOLOGY*ANGIOSARCOMA KHIC INDEX NUMBER 03888 REVIEW YEAR 1991 % DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAI6 ELGUT Order number 911001-135640-HIZ -001-007 page 59 set 15 with 574 of 574 items Item 161 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHCR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS **** KWIC INDEX NUMBER REVIEW YEAR 2551 GEN PUBLICATION MORTALITY AMONG EMPLOYEES OF PVC FABRICATORS. CHIAZZE L*NONE)NICHOLS HE,N0NE)N0NG O,N0NE) J OF OCCUPATIONAL MEDICINE* VOL 19(9) PP.625-628) 1977 A CROSS-SECTIONAL MORTALITY STUDY OF 4541 DEATHS OCCURRING AMONG CURRENT AND FORMER EMPLOYEES OF 17 PVC FABRICATORS DURING 1964-1973 IS PRESENTED. AMONG THE WHITE EMPLOYEES* THERE APPEARS TO BE AN EXCESS IN TOTAL CANCER MORTALITY, PARTICULARLY THAT OF THE DIGESTIVE SYSTEM. OBSERVED DEATHS HERE FOUND TO EXCEED THE EXPECTED IN CANCERS OF THE BREAST AND URINARY ORGANS AMONG WHITE FEMALES. DEFICIT MORTALITY HAS OBSERVED IN CIRRHOSIS OF THE LIVER AMONG WHITE MALES AND FEMALES. PVC )VCM)HUMAN )EFFECTS)EPIDEMIOLOGY)CARCINOGENICITY)ANGIOSARCOMA 03867 1991 Item 182 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS * HELD TERMS KHIC INDEX NUWER REVIEW YEAR 2548 GEN PUBLICATION SMOKING AND OCCUPATIONAL CANCERS. HOFFMAhM D*NONE)WYNDER EL,NONE) PREVENTIVE MEDICINE* VOL 5(2) PP.245-261) 1976 A REVIEW OF THE LITERATURE SHOWS A LACK OF EPIDEMIOLOGICAL DATA FOR THE JOINT ACTION OF OCCUPATIONAL CARCINOGENS (NICKEL* COKE OVEN* GAS WORKERS, VCM, HALO ETHERS, BLADDER CARCINOGENS) AND TOBACCO SMOKE. SYNERGISTIC AND/OR ADDITIVE EFFECTS HAVE BEEN ESTABLISHED FOR RADON DAUGHTERS AND SOME FORMS OF ASBESTOS. SMOKE)CANCER)NICKLE)GAS)HORKERS)VINYL CHLORIDE)BLADDER)CARCINOGEN)ETHERS) COKE OVEN)HALO ETHERS)SYNER6ISM) 03721 1990 Item 183 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS 2346 GEN PUBLICATION CARCINOGENICITY OF VINYL CHLORIDE ANO VINYLIDENE CHLORIDE. LEE CC,NONE)BHANDARI JC,NONE)WINSTON JM,NONE)HOUSE HB*NONE)DIXON RL*NONE)WOODS JS,NONE) J OF TOXICOLOGY AND ENVIRONMENTAL HEALTH* VOL 4 PP.15-30) 1978 EXPOSURE OF MICE TO 50, 250, OR 1000 PPM OF VCM 6H/D,5D/WK FOR 12 MONTHS PRODUCED A HIGH INCIDENCE OF BRONCHIOLALVEOLAR ADENOMA, MAM1ARY GLAND TUMORS* AND HEMANGIOSARCOMAS. EXPOSURE TO 5 PPM OF VDC CAUSED HEMANGIOSARCOMAS ANO BRONCHIOLALVEOLAR ADENOMAS. VCM)VDC)CARCINOGENICITY)RATS)INHALATION q\ *0v o DATA SEARCH ON VCM/TQXICITY STUDIES FOR CRAIG ELGUT Order matter 911001-13S640-MIZ -001-007 page 60 set 13 with 374 of 374 items KWIC INDEX NUMBER REVIEW YEAR 03674 1990 Item 184 ACCESSION NUMBER 2345 FILE LOCATION GEN DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION PUBLICATION ANGIOSARCOMA OF THE LIVER IN VINYL CHLORIDE/POLYVINYL CHLORIDE WORKERS. SPIRTAS RNIOSH*KAMINSKI R,NIOSH> ORIGIN J OF OCCUPATIONAL MEDICINE, VOL 20 PP.427-429* DATE ABSTRACT 1978 THIS REPORT PROVIDES DETAILS ON 64 CASES OF ANGIOSARCOMA AMONG VCM POLYMERIZATION WORKERS AND UPDATES THE PREVIOUS REPORT OF 26 CASES tJOM 16:809,1974). DESCRIPTORS xxxxxx* VCM*ANGI0SARC0MALIVER*HUMAN*EFFECT5 KWIC INDEX NUMBER 03665 REVIEH YEAR 1990 Item 1B5 ACCESSION NUMJER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** HELD TERMS KWIC INDEX NUMBER REVIEH YEAR REPORT VINYL CHLORIDE AND HUMAN REPRODUCTION. MACMAHON B,HARVARD LNZV* NONE* 1977, AUGUST 11 VCM*REPRO0UCTZ0N*BIRTH DEFECTSjTERATOGENICITYjHUMANjEFFECT FETAL LOSS* 03648 1990 Item 166 ACCESSION NUT6ER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 2340 GEN PUBLICATION EFFECTS OF VINYL CHLORIDE IN MAN A CYTOGENETIC FOLLOW-UP STUDY. HANSTEEN X>l*KNOttt)HXLLESTAO L,UNCNO*WTHIIS-EVENSEN EUMtNQttt*HELDAAS SS,UM(NOM> MUTATION RESEARCH, VOL 51 PP.271-278* 1978 THE MEAN CHROMOSOME-BREAKAGE FREQUENCY FOR THE WORKERS*3.41*> HAS SIGNIFICANTLY HIGHER THAN FOR THE CONTROLS (1.79Z) IN THE FIRST INVESTIGATION. IN THE REPEATED STUDY NO DIFFERENCE HAS FOUND IN MEAN CHROMOSOME-BREAKAGE FREQUENCY BETWEEN THE WORKERS AND THEIR HATCHED CONTROLS. NEITHER HAS THERE ANY DIFFERENCE BETWEEN THESE BREAKAGE FREGENCIES AND THE BREAKAGE FREQUENCY FOR THE PREVIOUS CONTROL GROUP. THESE RESULTS MIGHT INDICATE A RELATIONSHIP BETWEEN THE REDUCTION IN EXPOSURE TO VCM AND THE NORMALIZED CHROMOSOME-BREAKAGE FREQUENCY. SISTER-CHROMATID EXCHANGES HERE STUDIED FOR 16 WORKERS HITH MATCHED CONTROLS IN THE REPEATED STUDY. A MEAN OF 7.6 SCES PER CELL HAS FOUND FOR BOTH WORKERS AND CONTROLS. BONE-MARROW SAMPLES FROM 4 WORKERS HERE STUDIED IN THE FIRST INVESTIGATION. THE MEAN CHROMOSOME-BREAKAGE FREQUENCY HAS HIGHER IN THE BONE MARROWS *4.2X) 22521060 0529*1 DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order number 911001-135640-WIZ -001-007 page 61 set 13 with 374 of 374 items DESCRIPTORS REVIEW YEAR THAN THAT REPORTED FOR NORMAL BONE MARROWS (0.2, 0.4, 1.7Z) AND HIGHER THAN FOR THE CORRESPONDING LYMPHOCYTE CULTURES. *xxxx*x YCM)HUMAN>EFFECTS}CHROMOSOMAL ABERRATIONjCHROMOSOMAL ABNORMALITIES^MUTAGENICITY 1990 Item 107 ACCESSION NUMBER 2338 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT PATHOLOGY OF VINYL CHLORIDE AUTHOR/AFFILIATION VIOLA PL,UM(NQW} ORIGIN NONE,VOL 61 NO.3 PP.1-7} DATE 1970 ABSTRACT THE RESULTS OF THIS INVESTIGATION SHOW THAT ANIMALS EXPOSED TO VCM MAY SHOW DEGENERATION OF THE SKELETON AND CQWECTCVE TISSUE SIMILAR TO HUMAN ACROOSTEOLYSIS OF THE HAND. DEGENERATIVE PROCESSES OF THE PARENCHYMA MERE OBSERVED IN THE BRAIN, LIVER, AND KIDNEYS. DESCRIPTORS xxxxxxx VCM}PATHOLOGY}CHRONIC>EFFECTS}XNHALATXON}RATS}BONES}KXDNEY}LXVER}BRAIN}ACROOSTEOLYSIS HELD TERMS LA MEDICINA DEL LAVORO} REVIEW YEAR 1990 Item 188 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** KHIC INDEX NUMBER REVIEW YEAR 2287 GEN REPORT EXCERPT FROM LETTER HRITTEN BY DR E MASTROMATTEO, DIVISION OF INDUSTRIAL HYGIENE, DEPARTMENT OF HEALTH, PROVINCE OF ONTARIO, DATED OCTOBER 13, 1959, REGARDING VINYL CHLORZDE EXPERIMENTS ON SMALL ANIMALS. MASTROMATTEO E,N0NE> NONE,TO CROW ATTORNEY} 1959, OCTOBER 13 THIS SUMMARY REPORTS THE RESULTS OF 30 MINUTE EXPOSURES TO RODENTS. MICE}RATS}GUINEA PIGS1EFFECTS}ACUTE>VCM>INHALATION 02721 1990 Item 189 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS xxx** HELD TERMS KHIC ' 'EX NUWJER 2286 GEN PUBLICATION ACCIDENTAL POISONING BY VINYL CHLORIDE: REPORT OF THO CASES DANZIGER H,UNKNOWN} NONE,VOL 82 PP.828-830} I960, APRIL 16 ACUTE INHALATION EFFECTS FORM VCM NOTED. VCM}HUMAN}E FFECTS}INHALATION}ACUTE CANAD.h.A.J}CANADIAN MED ASSOC J} 02715 ZZZiZlOSl ao 0\ o* vO O y* (ft 'A \ f \ S \ s. Si s / s DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order rW>er 911001-135640-HIZ -001-007 page 62 set 13 with 374 of 374 items REV1EN YEAR 1990 Item 190 ACCESSION NUtCER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS xxxxxxx KWIC INDEX NUFBER REVIEW YEAR REPORT RISK-BENEFIT ANALISIS FOR TOXIC CHEMICALS: VINYL CHLORIDE. WILSON R,HARVARD UNIV) HARVARD UNIV) 1976, AUGUST 25 VCM)RISK ASSESSMENT(ANALYSIS ) HUMAN ) EFFECTS )CARCINOGENICITY 02606 1991 Item 191 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFZLIATION ORIGIN DATE DESCRIPTORS ****** HELD TERMS KHIC INDEX NUMBER REVIEH YEAR 2283 GEN PUBLICATION COM1ISSION DIRECTIVE OF 29 APRIL 1981 LAYING DOW THE COMMUNITY METHOD OF ANALYSIS FOR THE OFFICIAL CONTROL OF VINYL CHLORIDE RELEASED RELEASED BY MATERIALS AND ARTICLES INTO FOODSTUFFS. UNKNOW,UMCNOW ) NONE,VOL 24PP.6-11) 1981, JUNE 24 VCM) ANALYSIS) OFFICIAL JOURNAL OF EEC)FOODSTUFFS) 02583 1990 Item 192 ACCESSION NUtSER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** HELD TERMS KHIC INDEX NUMBER REVIEW YEAR 2261 GEN PUBLICATION FATE OF 14C-VINYL CHLORIDE AFTER SINGLE ORAL ADMINISTRATION IN RATS. HATANABE P6,00H CHEMICAL COjMCGOHAN GR,SAME)GEHRING PJ,SAME> TOX AND APPLIED, VOL 36 PP.339-352) 1976 THE FATE OF VCM FOLLOWING AN ORAL DOSE BETWEEN 1 AND 100 MG/KG WAS CLEARLY DOSE-DEPENDENT. CONSISTENT WITH OUR PREVIOUS STUDIES ON THE FATE OF VCM FOLLOWING INHALATION EXPOSURE IN RATS, THE METABOLISM OF VCM APPEARS TO BE A SATURABLE PROCESS. RATS)ORAL)VCM)METABOLISM) DISPOSITIONsMETABOLIC FATE) 02579 1990 Item 193 ACCESSION NUMBER 2276 2 X \0 O i DATA SEARCH ON VCM/TQXICITY STUDIES FOR CRAIG ELGUT Order nuifeer 911001-135640-HIZ -001-007 page 63 set 13 with 374 of 374 items FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT ELEVATED CEA (CARCINO-EMBRYONXC ANTIGEN) LEVELS IN POLYVINYL CHLORIDE WORKERS. AUTHOR/AFFILIATION PAGE M,UMNOHNTHERIAULT LUNKNOHN)DELORME F,UMtN0m> ORIGIN NONE,VOL 25 PP.279) DATE ABSTRACT 1976 PLASMA CEA TITER HAS MEASURED IN 200 PVC WORKERS. A POSITIVE TEST HAS OBTAINED IN 48.3* COMPARED TO 9.2Z IN A NORMAL HEALTHY POPULATION. DESCRIPTORS xxxxxx* PVC)VCMjCANCER)DETERMINATION)HUMAN)EFFECT) HELD TERMS BIOMEDICINE) KHIC INDEX NUMBER 02S76 REVIEW YEAR 1990 Item 194 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS *** KHIC INDEX NUMBER REVIEW YEAR 2276 GEN PUBLICATION TEN CASES OF ANGIOSARCOMA OF THE LIVER IN SHAHINIGAN, QUEBEC. DELORME F>UNKNOtM)THERIAULT G.UWNOW) J OF OCCUPATIONAL MEDICINE, VOL 20 PP.338-340) 1978, MAY TEN CASES OF ANGIOSARCOMA HAVE BEEN DIAGNOSED IN SHAHINIGAN SINCE 1955. ALL WORKED IN A VCM POLYMERIZATION PLANT. CIGARETTES AND ALOCOHOL HERE NOT ASOCXATED WITH THE TUMORS. ANGIOSARCOMA IS ACCOMPANIED BY FIBROSIS IN THE LIVER AND MAY PRECEDE ITS APPEARANCE. VCM)ANGIOSARCOMA)HUMAN)EFFECTS)EPIDEMIOLOGY)LIVER)FIBROSIS 02547 1990 Item 195 ACCESSION NUfBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT Al/THOR/'AFFI LXATION ORIGIN DATE ABSTRACT DESCRIPTORS XXXXM1 KHIC INDEX NUMBER REVIEW YEAR 2275 GEN PUBLICATION VINYL CHLORIDE EXPOSURE IN A CONTROLLED INDUSTRIAL ENVIRONMENT;" A LONG-TERM MORTALITY EXPERIENCE IN 594 EMPLOYEES. OTT MG,DON CHEMICAL CO)LANGNER RR,SAME)HOLDER B8,SAME) ARCH ENVIRON HEALTH, VOL 30 PP.333-339) 1975, JULY , A MORTALITY STUDY OF 594 VCM-EXPOSED EMPLOYEES NAS CONDUCTED. NO ANGIOSARCOMAS OR DEATHS FROM LIVER DISEASE HAS FOUND. VCM)EPIDEMIOLOGY)HUMAN|EFFECTS)LIVER 02540 1990 Item 196 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE 2274 GEN PUBLICATION 2252106,m xJ BFG52940 J J O 5 5 o o O I i DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order rxrber 911001-135640-HIZ -001-007 page 64 set 13 with 374 of 374 items TITLE OR SUBJECT ALTTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ** HELD TERMS KWIC INDEX NUTBER REVIEW YEAR HEPATIC ANGIOSARCOMA ASSOCIATED WITH ANDROGENIC-ANABOLIC STEROIDS. FALK H,CDC*POPPER H,NCI*THOMAS LB,CITY UNIV OF NEW YORKjISAK KG,NONE) NONE PP.1120-1123) 1979, NOVEMBER 24 A STUDY OF DEATHS FROM HEPATIC ANGIOSARCOMA (HAS) IN THE US SHOWED THAT DURING 1964-74 THERE WERE 166 SUCH CASES, OF HHICH 37 (22Z) MERE ASSOCIATED WITH VCM, THOROTRAST, AND INORGANIC ARSENIC AND 4 (3.IX) OF THE REMAINING 131 CASES WITH THE USE OF ANDROGENIC-ANABOLIC STEROIDS. VCM*ANGIOSARCOHA*LIVERHUMAN*EFFECTSEPIDEMIOLOGYTHOROTRAST* STERIODSjINORGANIC ARSENIC*LANCET*STERIODS)HALTER REED ARMY MEDICAL CENTER* 02527 1990 Item 197 ACCESSION NUMBER 2273 FILE LOCATION GEN DOCUMENT TYPE REPORT TITLE OR SUBJECT QUANTITATIVE RISK ASSESSMENT FOR C0W1UNITY EXPOSURE TO VINYL CHLORIDE. author/aff/liation KUZMACK AM,EPA)MCGAUGHY RE,EPA* ORIGIN EPA* DATE 1975, DECEMBER 5 ABSTRACT IT NAS FOUND, USING ANIMAL DATA AND USING A LINEAR DOSE-RESPONSE MODEL EXTRAPOLATING TO ZERO, THAT THE PROBABILITY OF GETTING ANGIOSARCOMA DUE TO A YEAR OF CONTINUOUS EXPOSURE TO VCM IS 71 CASES PER YEAR PER MILLION PEOPLE EXPOSED. THE CORRESPONDING PROBABILITY OF GETTING CANCER OF ALL SITES IS 150 CASES PER YEAR OF CONTINUOUS EXPOSURE PER PPM OF VCM PER MILLION PEOPLE. ON THIS BASIS THE PROBABILITY OF GETTING LIVER ANGIOSARCOMA IN WORKERS EXPOSED TO 350 PPM FOR 7 HOURS PER i DAY, 5 OAYS PER WEEK MOULD BE 0.0052 PER PERSON PER YEAR OF EXPOSURE. FROM EPIDEMIOLOGY STUDIES IT HAS ESTIMATED THAT THE PROBABILITY OF GETTING ANGIOSARCOMA AT SOME TIME IN A WORKERS LIFE PER YEAR OF EXPOSURE IS 0.0031. IT IS CONCLUDED THAT THE DIFFERENCE IN RISK ESTIMATES BETWEEN ANIMAL AND HUMAN DATA IS INDISTINGUISHABLE. DESCRIPTORS *xk* VCM *CARCINOGENICITY*ANGIOSARCOMA*HUMAN* EFFECTS*RISK ASSESSMENT KMIC INDEX NUMBER 02516 REVIEW YEAR 1990 Item 198 ACCESSION NUMBER 2272 FILE LOCATION * DOCUMENT TYPE GEN REPORT TITLE OR SUBJECT REPORT ON A MORTALITY STUDY COVERING EMPLOYEES OF PVC FABRICATORS. AUTHOR/AFFILIATION NONE,NONE* ORIGIN NONE* DATE 1976, FEBRUARY DESCRIPTORS ***** PVC*VCM*HUMAN*EFFECTS*EPIDEMIOLOGY> HELD TERMS ORGANIZATION RESOURCES COUNSELORS INCjFABRICATORS* KMIC INDEX NUMBER 02431 REVIEW YEAR 1991 Item 199 I DATA SEARCH ON VCH/TOXICITY STUDIES FOR CRAIG ELGUT Order nuifcer 911001-135640-MIZ -001-007 page 65 sat 13 with 374 of 374 items ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ****: HELD TERMS KHIC INDEX NUMBER REVIEW YEAR 2271 GEN PUBLICATION MORTALITY STUDY OF WORKERS IN THE MANUFACTURE OF VINYL CHLORIDE AND ITS POLYMERS. TABERSHAH IR,NONE)GAFFY HRSAME)TABERSHAH-COOPER ASSOC) J OF OCCUPATIONAL MEDICINE* VOL 16(6) PP.509-518) 1974, AUGUST THIS MORTALITY STUDY OF 8384 MEN DEMONSTRATED THAT CANCERS OF THE DIGESTIVE SYSTEM (ANGIOSARCOMAS), RESPIRATORY SYSTEM, BRAIN, AND CANCERS OF UNtfOW SITE, AS NELL AS LYMPHOMAS, OCCURRED MORE OFTEN THAN EXPECTED IN THOSE INDIVIDUALS WITH THE GREATEST ESTIMATED EXPOSURE. EXCESS CANCERS OF THE BUCCAL CAVITY AND PHARYNX WERE INVERSELY RELATED TO EXPOSURE. VCM>PVC>HUMAN)EFFECT)EPIDEMIOLOGY)CANCER)RESPIRATORY SYSTEMjBRAIN)ANGIOSARCOMA TABERSHAH-COOPER ASSOCIATES INC) DIGESTIVE SYSTEM) 02376 1990 Item 200 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** KHIC INDEX NUMBER REVIEW YEAR 2260 GEN PUBLICATION MUTAGENIC AND CARCINOGENIC EFFECTS OF VINYL CHLORIDE. BARTSCH H,IARC)MONTESANO R,IARCl MUTATION RESEARCH, VOL 32 PP.93-114) 1975 A REVIEW OF CARCINOGENICITY, MUTAGENICITY, METABOLISM, AND NON-NEOPLASTXC EFFECTS OF VCM. VCM)CARCINOGENICITY)MUTAGENZCITY)METABOLISM)ACROOSTEOLYSIS 02340 1990 Item 201 ACCESSION NUTBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** HELD TERMS KHIC INDEX NUMBER REVIEW YEAR 2259 GEN PUBLICATION VINYL CHLORIDE DEPENDENT MUTAGENESIS {EFFECTS OF LIVER EXTRACTS AND FREE RADICALS. GARRO JB,CITY UNIV OF NEW YORKiGUTTENPLAN JB,CITY UNIV OF NEW YORK) MUTATION RESEARCH, VOL 36 PP.61-86) 1976 VCM MUTAGENICITY IN S. TYPHIMURXUH NAS ENHANCED 8Y LIVER EXTRACTS AND RIBOFLAVIN IN THE PRESENCE OF SUNLIGHT. VCM)MUTAGENICITY)IN VITRO)LIVER> ACTIVATI0N)RI8OFLAVXN)SUNLIGHT) 02339 1990 Item 202 ACCESSION NUTCER FILE LOCATION 2257 GEN 3 c* \n O C& u Q O o o Q DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order nuifcer 911001-135640-HIZ -001-007 page 66 set IS with 374 of 374 items DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS xxxxxxx REVIEW YEAR PUBLICATION PULMONARY FUNCTION DEFECTS IN NONSMOKING VINYL CHLORIDE WORKERS. MILLER A,CITY UNIV OF NEW YORK} ENVIRONMENTAL HEALTH PERSPECTIVES,VOL 11 PP.247-2501CN SHELF)} 1975 VCM>PVC}HUMANS}EFFECTS}PULMONARY FUNCTION 1995 Item 203 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHQR/AFFILIATION ORIGIN DATE DESCRIPTORS xxxxx; HELD TERMS REVIEW YEAR 2256 GEN PUBLICATION BIOCHEMICAL TOXICOLOGY OF UNSATURATED HAL06ENATED MONOMERS. JAEGER RJ,HARVARD (JNIV}CONOLLY RB,SAME}REYNOLDS ESSAME}MURPHY SO,SAME} ENVIRONMENTAL HEALTH PERSPECTIVES,VOL 11 PP.121-1251ON SHELF)} 1975 VCM>1,1-DICHL0R0ETHYLENE)RATS}ACUTE}LIVER} HEPAT0T0X1CITY}ENZYMES} 1,1-DIBROMOETHYLENE} 2-CHLORO-1,3-BUTADIENE} 1995 Item 204 ACCESSION NUFCER 2255 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT PRELIMINARY STUDIES ON THE FATE OF INHALED VINYL CHLORIDE MONOIER (VCM) IN RATS. AUTHOR/AFFILIATION HEFNER RE,DOH CHEMICAL COlNATANABE PG,SAME}GEHRXNG PJ,SAME} ORIGIN ENVIRONMENTAL HEALTH PERSPECTIVES,VOL 11 P.&5-95I0N SHELF)} DATE 1975 ABSTRACT CONSIDERING THE RESULTS IN TOTO, IT IS HYPOTHESIZED THAT VCM IS READILY AND EXTENSIVELY METABOLIZED. METABOLISM VIA THE PRIMARY PATHWAY, POSTULATED TO INVOLVE ALCOHOL DEHYDROGENASE, IS SWAMPED BY EXPOSURES TO CONCENTRATIONS EXCEEDING 220 PPM. IN RATS EXPOSED TO CONCENTRATIONS AT AND EXCEEDING THIS LEVEL, METABOLISM OCCURS VIA A SECONDARY PATHNAY(S). POSTULATED TO BE EPOXIDATION AND/OR PEROXIDATION* THESE RESULTS ARE CONSIDERED PERTINENT IN ASSESSING THE POTENTIAL HAZARD AT LOW LEVEL EXPOSURES TO VCM. DESCRIPTORS xxxxxxx VCM}METABOLISM}INHALATION}RATS REVIEW YEAR 1990 Item 205 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 2254 GEN PUBLICATION PROPORTIONAL MORTALITY AMONG VINYL CHLORIDE WORKERS. MONSON RR,HARVARD UNIVlPETERS JM,SAME>JOHNSON t*4,BFG} ENVIRONMENTAL HEALTH PERSPECTIVES,VOL 11 PP.75-77(0N SHELF)} 1975 IN A PROPORTIONAL MORTALITY ANALYSIS OF 161 DECEASED WORKERS IN TWO PLANTS PROCESSING OR PRODUCING VCM, A 50* EXCESS OF DEATHS DUE TO ALL CANCER WAS SEEN. LIVER, BILIARY TRACT, LUNG, AND BFG543 J J DATA SEARCH ON VCH/TOXICITY STUDIES FOR CRAIG ELGUT Order nuiker 911001-135660-HIZ -001-007 page 67 set 13 with 376 of 376 items BRAIN CANCERS SHOWED THE GREATEST EXCESS. DESCRIPTORS xxxxxxx VCM>HUMAN}CANCER>EFFECTS}LIVER>BRAIN}LUNG REVIEW YEAR 1995 Item 206 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ****** HELD TERMS REVIEW YEAR 2251 GEN PUBLICATION OBSERVATIONS ON THE ORAL ADMINISTRATION AND TOXICITY OF VINYL CHLORIDE IN RATS. FERON VJiNONE}SPEEK AJSAME}NXLLEMS HI,SAME}VAN BATTUH DSAMElDE GROOT AP,SAME| NONE)VOL 13 PP.633-6381 1975 NO LIVER DAMAGE FROM ORAL ADMINISTRATION OF VCM AS HIGH AS 300 MG/KG, 6 DAY/NEEK FOR 13 WEEKS VCMJORAL )SUBCHRONIC >RATS CIVOiCENTRAL INSTITUTE FOR NUTRITION A FOOD RESEARCH) FD.COSMET.TOXICOL} 1990 Item 207 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS xxxxx HELD TERMS REVIEW YEAR 2250 GEN PUBLICATION THE BIOLOGICAL FATE IN RATS OF VINYL CHLORIDE IN RELATION TO ITS ONCOGENICITY GREEN TICI|HATHHAY 0E,ICI NONE>VOL 11 PP.565-5621 1975 VCMMETABOLISM)ORALIRATS > IV11PIRATSI CHEM-BIOL INTERACTIONS} 1990 Item 208 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS HELD TERMS REVIEW YEAR ****** 2269 GEN PUBLICATION MUTAGENICITY OF CHLOROACETALDEHYDE, A POSSIBLE METABOLIC PRODUCT OF 1)2-DICHLOROETHANE (ETHYLENE DICHLORIDE), CHLOROETHANOL (ETHYLENE CHLOROHYDRIN), VINYL CHLORIDE, AND CYCLOPHOSPHAMIDE. MCCANN J,UNIV OF CALIFORNIA iSIlfiON V,NONE I STREITHIESER D,IWIV OF CALIFORNIAlAMES BN,UNIV OF CALIFORNIA} NONE,VOL 72 NO.8 PP.3190-3193} 1975, AUGUST VCMiMUTAGENICITY)IN VXTRO}HETABOLXTEiCHLOROACETALDEHYDE}EDC}CYCLOPHOSPHAMIDEI CHLOROETHANOLISTANFORD RESEARCH INSTITUTE}PROC.NAT.ACAD.SCI} 1990 Item 209 ACCESSION NUMBER FILE LMATION 2267 GEN 2252106' / BFG52944 ) -) 3 3 3 O o DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order number 911001-135640-HIZ -001-007 page 68 set 13 with 374 of 374 items DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT AN EPIDEMIOLOGIC STUDY OF BLOOD SCREENING TESTS AND ILLNESS HISTORIES AMONG CHEMICAL WORKERS INVOLVED IN THE MANUFACTURE OF POLYVINYL CHLORIDE. AUTHOR/AFFILIATION WYATT RH>UN<NCim)KOTCHEN JM,UNKNOWN(HOCHSTRASSER DLUWN0W(BUCHANAN JW,UM<LNOW>CAMBELL DR, UNKNOWN SLAUGHTER JC,UN<NOHN|DOLL AH,UM(N0HN) ORIGIN ANNALS OF THE NEH YORK ACADEMY OF SCIENCES, VOL. 246 PP.80-87) DATE 1975, JANUARY 31 DESCRIPTORS xxxxxxx PVC(VCM)HUMAN)EFFECTS) HELD TERMS CLINICAL CHEMISTRY ) REVIEW YEAR 1995 Item 210 ACCESSION NUTOER 2245 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT HEPATIC DISEASE AMONG WORKERS AT A VINYL CHLORIDE POLYMERIZATION PLANT. AUTHOR/AFFILIATION FALK HCDC)CREECH JL,BFG)JOHNSON W,BFS|KEY mCDC ORIGIN JAMA, VOL.230(1) PP.59-68 DATE 1974, OCTOBER 7 ABSTRACT 11 CASES OF HEPATIC DISEASE INCLUDING ANGIOSARCOMA HAVE BEEN IDENTIFIED AT A VCM POLYMERIZATION f PLANT. DESCRIPTORS xxxxxxx VCM)PVC}ANGIOSARCOMA)LIVER>HUMANjEFFECTS REVIEW YEAR 1995 Item 211 o ACCESSION NUMBER 2244 FZLE LOCATION GEN c DOCUMENT TYPE TITLE OR SUBJECT PUBLICATION CLINICAL AND MORPHOLOGIC FEATURES OF HEPATIC ANGIOSARCOMA IN VINYL CHLORIDE WORKERS. AUTHOR/AFFILIATICN MAKK LUNIV OF LOUISVILLElOELMORE F,NONE)CREECH JL,BFG)OGDEN LL,UNIVERSITY OF LOUISVILLE)FADELL EH .UNIVERSITY OF LOUISVILLE (SONGSTER CL, UNIVERSITY OF LOUISVILLE (CLANTON J,NONE (JOHNSON MNBFG) CHR1ST0PHERS0N W,UNIVERSITY OF LOUISVILLE ORIGIN CANCER, VOL. 37 PP.149-163) DATE ABSTRACT 1976 15 HALE VCM WORKERS DEVELOPED ANGIOSARCOMA OF THE LIVER. AVERAGE AGES WERE 36 TO 58. EXPOSURE TIME RANGED FROM 4 TO 27.6 YRS (AVG. 16.9 YRS). DESCRIPTORS VCM)ANGIOSARCOMA )LXVER)HUMAN)EFFECTS) HELD TERMS SUBURBAN HOSPITAL)UNIV OF MONTREAL) MORPHOLOGY) REVIEW YEAR 1995 Item 212 ACCESSION NUMBER FILE LOCATION DOCUCMT TYPE >- ' - ' Tme OR SUBJECT AUTHOR/AFFIL2ATION j ORIGIN W . 2243 ; OFN^ ^v PUBLICATION LlVtK DAMAGE AND ANQZOSAISOMA ZN VINYL CHLORIDE WORKERS Hdfc|J.5NdNE(CREECH JL,BFBllttELAN JO,NONE (JOHNSON m,BFG> JArtA^VOL. 230 PP.65-68) . :-s ' ,, 22521063 BPgS294s J O o O o 9 DATA SEARCH ON VCM/TOXICXTY STUDIES FOR CRAIG ELGUT Order number 911001-135640-HIZ -001-007 page 69 set 13 with 374 of 374- items DATE ABSTRACT DESCRIPTORS REVIEW YEAR 1974, OCTOBER 7 RECENTLY, 5 CASES OF HEPATIC ANGIOSARCOMA HERE FOUND IN LOUISVILLE. ALL OF THE PATIENTS HAD WORKED IN A PLANT ENGAGED IN THE PRODUCTION OF PVC. A SYSTEMIC HEALTH SURVEILLANCE PROGRAM HAS INSTITUTED TO DETECT EXISTING LIVER DAMAGE OR ANGIOSARCOMA AND TO FIND EARLY SIGNS OF DEVELOPING LIVER DAMAGE. 1183 EMPLOYEES HERE TESTED. TWO NEH CASES OF HEPATIC ANGIOSARCOMA AND THREE CASES OF PORTAL FIBROSIS HERE DISCOVERED. *xx*x VCMjANGIOSARCOMA}LIVER}HUMAN}EFFECTS 1995 Item 213 ACCESSION WTOER 2241 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT CAPILLARY ABNORMALITIES IN POLYVINYL CHLORIDE WORKERS; EXAMINATION BY IN VIVO MICROSCOPY. AUTHOR/AFFILIATION MARICQ HR,NONEjJOHNSON MN,BFG)HHETSTONE CL,NQNE)LEROY EC,SAME) ORIGIN JAMA, VOL. 236 PP.1368-1371) DATE 1976, SEPTEMBER 20 ABSTRACT EXAMINATION BY HIDE-FIELD CAPILLARY MICROSCOPY OF THE HANDS OF 152 WORKERS IN VINYL CHLORIDE POLYMERIZATION PLANTS DEMONSTRATED SCATEREO, SCLERODERMA-LIKE MICROVASCULAR ABNORMALITIES IN 21 WORKERS AND ISOLATED CAPILLARY ABNORMALITIES IN 27, AS COMPARED WITH ONLY 3 ISOLATED ABNORMALITIES IN 50 MANUAL WORKERS NOT EXPOSED TO VCM. THIRTEEN OF 17 VCM WORKERS WITH OBJECTIVE EVIDENCE OF VCM-ASSOCIATEDABNORMALITIES (ANGIOSARCOMA, ETC.) HERE OBSERVED TO HAVE MICROVASCULAR ABNORMALITIES. DESCRIPTORS xxxxxxx VCM)HUMAN}EFFECTS)PVC) HELD TERMS REVIEW YEAR MEDICAL UNEV OF SOUTH CAROLINA)CGNOCO)CIRCULATION> 1995 Item 214 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS xxxxxxx HELD TERMS REVIEW YEAR 2240 GEN PUBLICATION IN VITRO SKIN CAPILLARY ABNORMALITIES IN VINYL CHLORIDE WORKERS. MARICQ HR,NONE)JOHNSON Ft4,BFG)HHETST0NE CL,NONE)LEROY EC,SAME) NONE,VOL 2 PP.235-237) 1976 VCMHUMAN)EFFECTS> MEDICAL UNIV OF SOUTH CAROLINA)CIRCULATION)MICROCIRCULATION) 1995 Item 215 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE 2239 GEN PUBLICATION GENETIC RISKS OF VINYL CHLORIDE. INFANTE PF,NIOSH)HAGONER JK,NIOSH)MCMICHAEL AJ,NIOSH)HA>MEILER RJ,NIOSH)FALK HjNIOSH THE LANCET,PP.1289-1290) 1976, JUNE 12 BFG52946 DATA SEARCH ON VCH/TOXICITY STUDIES FOR CRAIG ELGUT Order number 911001-135690-HIZ -001-007 page 70 set 13 with 379 of 379 items ABSTRACT DESCRIPTORS REVIEW YEAR RESPONSE TO DR. PADDLE'S LETTER TO THE EDITOR.REFERENCES METHOD OF DATA COLLECTION USED IN THEIR STUDY PUBLISHED IN LANCET, APRIL 13, 1976CREFER TO AN-3108K ******* VCM(REPRODUCTION(BIRTH DEFECTS (FETAL TOXICITY (MUTAGENICITY (HUMAN (EFFECTS*) EPIDEMIOLOGY ( TERATOGENICITY 1990 Item 216 ACCESSION NUtBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ****** HELD TERMS KKIC INDEX NUTBER REVIEW YEAR 2205 GEN PUBLICATION PHARMACODYNAMICS AND UPTAKE OF VINYL CHLORIDE MONOMER ADMINISTERED BY VARIOUS ROUTES TO RATS. HITHEY JR,NONE( J OF TOXICOLOGY AND ENVIROttlENTAL HEALTH,VOL 1 PP.381-399( 1976 TO ASSESS THE HARARD PRESENTED BY THE ORAL INGESTION OF VCM, CAMULATED RATS HERE INTUBATED KITH 2 MG/ML VCM IN MATER.VCM UPTAKE HAS VERY RAPID. PEAK CONCENTRATIONS HERE REACHED 10 MIN AFTER DOSING. ELIMINATION APPEAR BIEXPONENTIAL. VCM INHALATION AT 7000 PPM ALSO SHOWS A SIMILAR RAPID UPTAKE FOLLOWED BY A PLATEAU. BLOOD LEVELS FELL RAPIDLY TO BARELY DETECTABLE LEVELS AFTER 2 HOURS. VCM(PHARMACOKINETICS(ORAL(INHALATION(RATS(DISPOSITION(ELIMINATION DISPOSITION( 01608 1990 Item 217 ACCESSION NUMBER 2203 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT MUTAGENICITY OF VINYL CHLORIDE, CHLOROETHYLENEOXIDE, CKLOROACETALDEWYDE AND CHLOROETHANOL. AUTHOR/AFFILIATION MALAVE7LLE C,IARC(BARTSCH H*XARC(BARBIN A,IARC>CAMUS AM,$AME(MONTESANO R,SAMECROISY A,N0NE> JACKGUIGNON P,N0NE( ORIGIN DATE NONE,VOL 63 NO.2 PP.363-370( 1975 ABSTRACT EXPOSURE OF S. TYPHIMURIUM STRAINS TA 1530, TA 1535 AND 6-96 TO VINYL CHLORIDE INCREASED THE NUtBER OF HIS+ REV./PLATE 16, 12 OR 5 TIMES OVER THE SPONTANEOUS MUTATION RATE. THE MUTAGENIC RESPONSE FOR TA 1530 STRAIN HAS ENHANCED 7, 9 OR 5-FOLO IN THE PRESENCE OF HUMAN, RAT OR MICE S-9. IN TAI530 CHLOROACETIC ACID SHOWED ONLY TOXIC EFFECTS, WHILE CHLOROACETALDEHYOE, CHLOROETHANOL AND CHLOROETHYLENEOXIDE CAUSED A MUTAGENIC RESPONSE. THE UTTER COMPOUND MAS A STRONG ALKYLATING AGENT. DESCRIPTORS KXXMMKM VCM(IN VITRO(MUTAGENICITY( HELD TERMS CHLOROETHYLENE OXIDE(CHLOROACETALDEHYOE(CHLOROETHANOL( BIOCHEMICAL AND BIOPHYSICAL RESEARCH CCmJNICATZONS( BIOCHEMICAL BIOPHYSICAL RESEARCH COttlUNICATION) KHIC INDEX NUMBER REVIEW YEAR 01506 1990 Item 218 ACCESSION NUMBER 2201 22321070 BFG5294J i. o w /" c f 4 4 4 4 DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order nunfcer 911001-135690-WIZ -001-007 page 71 set 13 with 379 of 379 items FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS XXXXXMX HELD TERMS KHIC INDEX NUhCER REVIEW YEAR GEN PUBLICATION ONCOGENIC AND MUTAGENIC RISKS IN COfUNITIES KITH POLYVINYL CHLORIDE PRODUCTION FACILITIES. INFANTE PF,N0NE) NONE) I97S AUTHOR REPORTS EXCESS CONGENITAL MALFORMATIONS IN COMMUNITIES HXTH PVC-PRODUCTIQN FACILITIESVCMlBZRTH DEFECTS)TERATOGENXCITY)CNS DEPRESSION*HUMANjEFFECTSlEPXDEKXOLOGY NYASlNEH YORK ACADEMY OF SCIENCE)0HI0 DEPT OF HEALTH) 01933 1990 Item 219 ACCESSION NUMBER 2199 FILE LOCATION GEN DOCUMENT TYPE TECHNICAL REPORT TITLE OR SUBJECT EVALUATION OF THE REISZNER MINIMONITOR CHARCOAL BADGE AS A VCh MONITOR (PART II) AUTHOR/AFFILIATION BORN JH,BFG) ORIGIN BFG,CORPORATE TECHNICAL SUPPORT STATUS REPORT 8509-84) DATE ABSTRACT 1985* AUGUST 12 BRECKSVXLLE REPORT OF J.H. BORN CONCERNING DEVELOPMENT AND EVALUATION OF THE REISZNER MINIMONITOR CHARCOAL BADGE FOR VINYL CHLORIDE SAMPLING. ALSO INCLUDES STATISTICAL ANALYSES REPORT OF A.M. FAXRLXE. DESCRIPTORS xx* VINYL CHLORIDE)METHOD)MONITORING EQUIPMENT) REVXEN YEAR 1991 Item 220 ACCESSION NUMBER 2192 FILE LOCATION GEN DOCUMENT TYPE PAPER TITLE OR SUBJECT FINAL DRAFT CRITERIA DOCUMENT FOR VINYL CHLORIDE AUTHOR/AFFILIATION NONE,NONE) ORIGIN EPA DATE ABSTRACT 1982, JANUARY HEALTH EFFECTS BRANCH/OFFICE OF DRZMCING HATER DISCUSSES PHYSICAL AND CHEMICAL PROPERTIES,HLMAN EXPOSURE,PHARMACOKINETICS,HEALTH EFFECTS,RISK ASSESSMENT AND MCL UNDER CONSIDERATION FOR VCM. DESCRIPTORS xxxxxxx VCM)DRINKXNS HATER)HUMANS|EFFECTS)CARCINOGENICITY)CHRONIC)TERATOGENICITY )f*JTAGENICITY) PHARMACOKINETICS) HELD TERMS MCDMAXIMUM CONTAMINANT LEVEL) REVIEM YEAR 1990 Item 221 ACCESSION NUTCER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION 2191 GEN EPA REPORT HEALTH EFFECTS ASSESSMENT FOR VINYL CHLORIDE NONE,NONE* *t*r.~**zi*& -TV'S* JL RFrf^OQdS o Q Q C /* C 4 4 | i < DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order ntmber 911001-135640-WIZ -001-007 page 72 set 13 Kith 374 of 374 items ORIGIN DATE ABSTRACT DESCRIPTORS REVIEW YEAR EPA,REPORT N0.PB86-134475) 1984> SEPTEMBER DOCUMENT REPRESENTS A BRIEFQUANTITATIVELY ORIENTED SCIENTIFIC SUMMARY OF HEALTH EFFECTS DATA. IT HAS DEVELOPED BY THE ENVIR0M1ENTAL CRITERIA AND ASSESSMENT OFFICE TO ASSIST THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE IN ESTABLISHING CHEMICAL-SPECIFIC HEALTH-RELATED GOALS OF REMEDIAL ACTIONS. IF APPLICABLECHEKICAL-SPECIFIC SUBCHRONIC AND CHRONIC TOXICITY INTERIM ACCEPTABLE INTAKES ARE DETERMINED FOR SYSTEMIC TOXICANTS, OR Ql* VALUESARE DETERMINED FOR CARCINOGENS FOR BOTH ORAL AND INHALATION ROUTES. A Ql* NAS DETERMINED FOR VINYL CHLORIDE BASED ON BOTH ORAL AND INHALATION EXPOSURE.VINYL CHLORIDE FOLLOWING INHALATION EXPOSURE HAS BEEN SHOWN TO BE CARCINOGENIC IN HUMANS,RATS,MICE AND HAMSTERS. USING DATA FOR TUMOR INCIDENCE IN RATS, A Ql* FOR HUMANS OF 2.5X10-2 (MG/KG/DAY)-l WAS ESTIMATED. NO DATA ARE AVAILABLE CONCERNING ORAL EXPOSURE IN HUMANS AND CANCER RISK. ON THE BASIS OF TOTAL TUMORS IN FEMALE RATS FED VINYL CHORIDE-CONTAINING DIETS, A HUMAN Ql* OF 2.3 (MG/KG/DAY)-l HAS ESTIMATED FOR ORAL EXPOSURE. ******* CARCINOGENICITYjVCMjRISK ASSESSMENT)EFFECTS)RAT$) 1990 Item 222 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS REVIEW YEAR 2121 GEN JOURNAL APPLICATION OF THE "FILTER MODEL" TO A RISK ASSESSMENT FOR VINYL CHLORIDE OLSON CSEPA)SCHAEFFER DJ,N0NE> J OF TOXICOLOGY AND ENVIRONMENTAL HEALTH,VOL 17 PP.1-22) 1986 THE FILTER MODEL HAS USED TO ESTIMATE THRESHOLDS FOR THE INDUCTION OF CANCER FROM MANY DOSE-RESPONSE SETS FOR INHALATION AND INGESTION EXPOSURE TO VINYL CHLORIDE FOR RAT AND INHALATION EXPOSURE FOR MOUSE. ESTIMATES FOR A VARIETY OF END-POINT COWINATIONS WERE LOG-NORMALLY DISTRIBUTED OVER ABOUT 2 DECADES FROM ABOUT 1 TO 100 PPM FOR INHALATION EXPOSURE TO RAT AND 0.1 TO 30 PPM FOR MOUSE. WHEN THE DATA IS TRANSFORMED TO "DOSE" (MILLIGRAMS PER KILOGRAM BODY WEIGHT PER DAY), THE ESTIMATES FOR INHALATION AND INGESTION EXPOSURE AND ALSO FOR RAT AND MOUSE ARE SIMILAR. ESTIMATES FOR DIFFERENT EXPERIMENTS CARRIED OUT FOR DIFFERENT DURATIONS OF TIME (SINGLE EXPOSURE TO 1 YR) ARE COMPARABLE. SINCE THE THRESHOLD IS AN INTRINSIC PROPERTY OF THE BIOLOGICAL SYSTEM, THE ESTIMATE, EVEN FROM A PROTOCOL FOR SHORT EXPOSURE AND LESS THAN LIFETIME OBSERVATION, CAN BE USED DIRECTLY IN A RISK ASSESSMENT AS THE MAXIMUM SAFE DOSE. VCKjRISK ASSESSMENT)CARCINOGENICITY)EFFECTS)HUMAN)RAT)HICE) 1995 Item 223 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 2116 GEN LITERATURE SEARCH CITATIONS FROM THE LIFE SCIENCES COLLECTION DATABASE--VINYL CHLORIDE: TOXICOLOGY (1978-1985) NONE,N0NE) NTIS,PB86-856119) 1986 THIS BIBLIOGRAPHY CONTAINS CITATIONS CONCERNING THE TOXICITY OF VINYL CHLORIDE AND POLYVINYL CHLORIDE FOLLOWING SHORT AND LONG TERM EXPOSURES. METABOLISM, CARCINOGENICITY, AND TERATOGENITIC POTENTIAL OF THESE SUBSTANCES ARE CONSIDERED. METHODOLOGY TO QUANTITATE THEIR PRESENCE IN BFG52949 DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order number 911001-135640-HIZ -001-007 page 73 set 13 with 374 of 374 items 22521073 DESCRIPTORS REVIEW YEAR ATMOSPHERIC DUST ANO BODY TISSUES ARE DISCUSSED. OCCUPATIONAL HAZARDS ARE ALSO NOTED. (THIS UPDATED BIBLIOGRAPHY CONTAINS 231 CITATIONS* 11 OP WHICH ARE NEW ENTRIES TO THE PREVIOUS EDITION.) ******* VCMjPVC*HUMAN)EFFECTS)ANGIOSARCOMA)CARCINOGENICITY jACUTEjMICE JRATS* RABBITS) 1990 Iiem 224 ACCESSION NUTSER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 2086 GEN JOURNAL OCCUPATIONAL EXPOSURE AND BRAIN TUMORS MOSS AR,UNIV OF CALIFORNIA) J OF TOXICOLOGY AND ENVIRONMENTAL HEALTH*VOL 16 PP.703-711) 1985 EPIDEMIOLOGICAL EVIOENCE OF AN OCCUPATIONAL RISK OF BRAIN CANCER HAS BEEN REPORTED IN FOUR INDUSTRIES WHERE CHEMICAL EXPOSURES ARE LIKELY* MOST RECENTLY IN A SERIES OF PROSPECTIVE STUDIES IN THE PETROCHEMICAL INDUSTRY. HOWEVER, ONLY IN THE CASE OF VINYL CHLORIDE EXPOSURE HAS AN OCCUPATIONAL CENTRAL NERVOUS SYSTEM CARCINOGEN BEEN IDENTIFIED. THIS REPORT REVIEWS THE CONVERGENCE OF EPIDEMIOLOGICAL AND LABORATORY EVIDENCE THAT ESTABLISHED THE OCCUPATIONAL CARCINOGENICITY OF VINYL CHLORIDE* AND DISCUSSES IN DETAIL THE CURRENT EVIDENCE FOR AN OCCUPATIONAL RISK OF BRAIN TUMORS IN THE PETROCHEMICAL INDUSTRY. BRAIN iTUMORS)VCM ) HUMAN)EFFECTS ) GLIOMAS) 1995 Item 225 ACCESSION NUTOER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS REVIEW YEAR 2068 GEN JOURNAL EXPOSURE TO VINYL CHLORIDE AND ANGIOSARCOMA OF THE LIVER:A REPORT OF THE REGISTER OF CASES FORMAN D#N0NE)BEM4ETT B*ICI)STAFFORD J*SAME)DOLL R*NONE) BRITISH J OF INDUSTRIAL MEDICINE,VOL 42 PP.750-753) 1985 THE ASSOCIATION OF PLASTIC MANUFACTURERS IN EUROPE MAINTAINS A REGISTER OF ALL CASES OF ANGIOSARCOMA OF THE LIVER (ASL) RESULTING FROM EXPOSURE TO VINYL CHLORIDE MONOMER (VCM).THIS REGISTER HAS RECORDED ALL KNOWN VCM RELATED CASES OF THE DISEASE WORLDWIDE THAT HAVE BEEN HISTOLOGICALLY CONFIRMED.ALTHOUGH LIKELY TO BE INCOMPLETE.IT IS THE MOST COMPREHENSIVE TABULATION OF SUCH CASES AVAILABLE AND,BY THE END OF 1984*118 MEN HAD BEEN REGISTERED .THE INFORMATION FROM ANALYSIS OF THE CASES CURRENTLY ON THE REGISTER IS USED TO HAKE AN APPROXIMATE PROJECTION OF THE NUTBER OF CASES TO BE EXPECTED IN THE FUTURE.THE CONCLUSION FROM THIS PROJECTION IS THAT THE INDUSTRY IS REACHING THE HALFWAY STAGE IN THE APPEARANCE OF VCM RELATED ASL. VCh)ANGIOSARCOMA)CARCINOGENICITY)HUMAN)EFFECTS)LIVER) 1990 Item 226 ACCESSION NUMBER FILE LOCATION 2038 GEN BpG52950 c* o I DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order number 911001-135640-WIZ -001-007 page 74 sat IS with 374 of 374 items DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS **** HELD TERMS KHIC INDEX NUTBER REVIEW YEAR JOURNAL TOXIC EFFECT OF ALIPHATIC CHLORINATED BYPRODUCTS FROM VINYL CHLORIDE PRODUCTION ON MARINE ANIMALS ROSENBERG RNONEiGRAHN 0,N0NE*J0HANSS0N LNQNE) HATER RESEARCH,VOL 9 PP.607-612* 1975 THE ACUTE TOXIC EFFECTS OF CHLORINATED ALIPHATIC HYDROCARBONS, FORMED AS BY-PRODUCTS FROM ONE SWEDISH AND ONE NORWEGIAN PLASTIC PRODUCTION FACTORY,WERE EXAMINED BY EXPERIMENTS WITH COO (GADUS MORHUA),SHRIMP (CRANGON) AND A POLYCHAETE (OPHYRYOTROCHA LABRONICA). THE TOXICITY OF 1, 2-DICHLOROETHANE--A DOMINATING COMPOUND OF THE BY-PRODUCTS--AND A DISTILLATE WITH HEAVIER COMPOUNDS WERE ALSO ESTIMATED. THE TOXICITY (4BH,LC50) RATIO BETWEEN THE CONCENTRATIONS OF A SWEDISH BY-PRODUCT >A NORWEGIAN BY-PRODUCT, AND DICHLOROETHANE HAS 1:9:34. THE EFFECTS OF 1, 2-DICHLOROETHANE,1,1,2-TRICHLOROETHANE AND 1,1,2-TRICHLOROETHENE ON THE REPRODUCTIVITY, AND ON THE SURVIVAL OF ADULTS OF OPHRYOTROCHA WERE STUDIED. THE REPRODUCTIVITY WAS AFFECTED BY THESE COMPONENTS IN FAR LOWER CONCENTRATIONS THAN THOSE HAVING ACUTE TOXIC EFFECTS ON ADULT SPECIMENS. IN ONE EXPERIMENT SERIES OPHRYOTROCHA MAS EXPOSED SUDDENLY TO THE TEST SOLUTIONS AND IN A SECOND SERIES THE FIRST PRESENTATION HAS MADE BY A SUCCESSIVE INCREASE OF THE CONCENTRATION DURING ONE HOUR. THE ESTIMATED 96-H LC50-VALUES FOR THE TEST WITH SUCCESSIVE INCREASE HERE 1:8-3:1 TIMES HIGHER THAN THOSE FOUND FOR THE TEST WITH SUDDEN EXPOSURE. IT IS SUGGESTED THAT A PHYSIOLOGICAL SHOCK IN THE START OF BIOASSAY EXPERIMENTS MIGHT HAVE REDUCED THE LC50- VALUES IN MANY PREVIOUS TESTS. VCM)EDC)EFFECTS)AGUATIC TOXICITY) 1,1,2-TRICHLOROETHANE) 1,1,2-TRICHLOROETHENE)CHLORINATED HYDROCARBONS) SWEDISH WATER AND AIR POLLUTION RESEARCH LAB) 01020PUBL 1990 Item 227 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** HELD TERMS KHIC INDEX NUTOER REVIEW YEAR 2037 GEN JOURNAL CARCINOGENITY BIOASSAYS OF VINYL CHLORIDE:CURRENT RESULTS MALTONI CNONE}LEFEKXNE G,NONE) ANNALS OF THE NEW YORK ACADEMY OF SCIENCESVOL 246 PP.195-216) 1975, JANUARY 31 STUDIES SHOW THAT VCM CAUSES CANCER IN RATS,MICE AND HAMSTERS (ANGIOSARCOMA AND POSSIBLY OTHER TUMORS). ANGIOSARCOMA) VCM) CARCINOGENICITY) RATS) MICE) HAMSTERS) INHALATION) EFFECTS) CHRONIC) LONG-TERM* 01019PUBL 1990 Item 228 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION 2034 GEN JOURNAL THE INFLUENCE OF SOME BYPRODUCTS FROM VINYLCHLORIDE PRODUCTION ON FERTILIZATION,DEVELOPMENT AND LARVAL SURVIVAL ON PLAICE,COD AND HERRING EGGS BRAATEN B,NONE)MOLLERUD FE>NONE)SOLEMDAL P,NONE) BFGS2951 ) l i DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order neither 911001-135640-KIZ -001-007 page 75 set 13 with 374 of 374 items 22 22 1.0VO ORIGIN NONE ,PP.81-90* OATE ABSTRACT 1972 THE EFFECT OF BYPRODUCTS FROM NORWEGIAN VXNYLCHLQRIDE PRODUCTION ON FERTILIZATION,EGG DEVELOPMENT AND LARVAL SURVIVAL HAS TESTED. EGGS AND LARVAE OF PLAICE,COD AND HERRING APPARENTLY SEEMED UNAFFECTED BY CONCENTRATIONS UP TO 10 PPM,BUT CONCENTRATIONS OF 100 ANO 50 PPM DELAY AND STOP DEVELOPMENT OF PLAICE EGGS IN AN EARLY STAGE. COD LARVAE SEEMED TO SURVIVE HIGH CONCENTRATIONS OF THE TOXIC SUBSTANCES FOR FAR LONGER PERIODS THAN DID I AND II YEAR GROUPS OF SAITHE. DESCRIPTORS mkxkkkic VCM* EFFECTS! AQUATIC TOXICITY! HELD TERMS INSTITUTE OF MARINE RESEARCH (NORWAY)! KNIC INDEXNUMBER 01016PUBL REVIEW YEAR 1991 Item 229 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS **** HELD TERMS KNIC INDEX NUMBER REVIEW YEAR 2031 GEN JOURNAL CHROMOSOME ABERRATIONS IN WORKERS EXPOSED TO VINYL CHLORIDE FUNES-CRAVIOTO F,N0NE!LAhBERT BSAME!LINDSTEN JSAME| EHREWJERG L,UNIV OF STOCKHOLMiNATARAJAN AT, SAME! OSTERMAN-GOLKAR S,SAME! THE LANCET*PP. 459-460! 1975, FEBRUARY 22 LYHPHOCYTE-CULTURES FROM WORKERS 17 EXPOSED,3 CONTROLS) HERE STUDIED. THE FREQUENCY OF ABNORMAL CULTURES WERE SIGNIFICANTLY HIGHER IN THE EXPOSED GROUP. VCM!HUMANS!EFFECTS!CHROMOSOMAL ABERRATIONlMUTAGENICITY! CHROMOSOMAL ABNORMALITIES! 01013PUBL 1990 Item 230 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** KNIC INDEX NUMBER REVIEW YEAR 2015 GEN JOURNAL COMBUSTION PRODUCTS FROM VINYL CHLORIDE MONOMER O'HARA MM,BFG! AIHA 1971, MARCH HCL|PHOSGENE!VCM! 00950PUBL 1991 Item 231 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION 1805 GEN PUBLICATION VINYL CHLORIDE-ASSOCIATED DISEASE LELBACH HK,NONElMARSTELLER HJ,N0NE! BFG52952 ) 'J O DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order number 911001-135640-HIZ -001-007 page 76 set 13 with 374 of 374 items ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR NONE,VOL 47 PP.1-110) 1981 THIS IS AN EXTENSIVE REVIEW COVERING PRODUCTION>TOXZCQLOGY CHEMICAL AGENTS^PATHOLOGY CONSIDERATIONS>NON-MALZGNANT DISEASE> ANGIOSARCOMA> AND MANY OTHER ASPECTS. *******f PVCjVCM}ACUTE &CHR0NIC ^CARCINOGENICITY )ANGIOSARCOMA)ACROOSTEOLYSISj MUTAGENICITY ^METABOLISM) PHARMACOKINETICS ) THRO*BOCYTOPENIA)UNIV OF BOW (GERMANY)ADVANCES IN INTERNAL MEDICINE AND PEDIATRICS) IWUNOLOGY) 1991 Item 232 ACCESSION NWBER 1801 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT MALIGNANT TUMORS OF THE LIVER AND LUNGS IN AN AREA NXTH A PVC INDUSTRY AUTHOR/AFFILIATIGN SARIC M,NONE)KULCAR Z,NONE)ZORZCA MNONE)GELIC I,NONE) ORIGIN ENVIROWENTAL HEALTH PERSPECTIVES,VOL 17 PP. 189-192) DATE 1976 OCTOBER ABSTRACT THE INCIDENCE OF MALIGNANT TUMORS OF THE LUNG AND BRONCHUS AND OF CYTOLOGXCALLY CONFIRMED PRIMARY MALIGNANT TUMOR OF THE LIVER NAS ANALYZED FOR A 4-YR PERIOD IN A CITY WITH SEVERAL FACTORIES> INCLUDING A PVC INDUSTRY. PRIOR TO THE STUDY TWO CASES OF ANGIOSARCOMA OF THE LIVER HERE DIAGNOSED IN WORKERS EMPLOYED IN PVC PRODUCTION. THE STUDY DOES NOT INDICATE THAT THE OCCURRENCE OF MALIGNANT TUMORS OTHER THAN ANGIOSARCOMA IS ASSOCIATED WITH EXPOSURE TO VINYL CHLORIDE. DESCRIPTORS *******t VCM)PVC)LIVER)EFFECTS)LUNG)ANGIOSARCOMAHUMAN)EPXDEMIOLOGY) HELD TERMS INSTITUTE FOR MEDICAL RESEARCH A OCCUPATIONAL HEALTH (YUGOSLAVIA)) REVIEW YEAR 1992 Item 233 ACCESSION NUMBER 1800 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT TUMORS IN PATIENTS NXTH ANGIOSARCOMA OF THE LIVER AUTHOR/AFFXLIATION VIAWA NJ>N0NE) ORIGIN NONE>VOL 95 NO.2 PP.166-186) DATE 1981* AUGUST ABSTRACT MOST PATIENTS WITH KELL-DOCUMENTED ANGIOSARCOMA OF THE LIVER HAVE NOT DOCUMENTED EXPOSURE TO ANY OF THESE THREE CHEMICALS (1),S0ME CONSIDERATION SHOULD ALSO BE GIVEN TO THE POSSIBILITY THAT OTHER AGENTS STRUCTURALLY SIMILAR TO VINYL CHLORIDE (SUCH AS CHLOROPRENE^TRICHLOROETHYLENE) MIGHT PLAY A ROLE IN THE CAUSE OF THIS AND POSSIBLY OTHER MALIGNANT DISORDERS. DESCRIPTORS ******* VCM)AN6I0SARC0MA)TH0R0TRAST)HUMAN)EFFECTS) HELD TERMS ARSENICALS)ANNALS OF INTERNAL MEDICINE) REVIEW YEAR 1992 Item 234 ACCESSION NUTOER FILE LOCATION DOCUMENT TYPE 1799 GEN JOURNAL ,,% ZZijsC JLOV '& J z> o w) O O a BpG52953 DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order nuiber 911001-135640-WIZ -001-007 page 77 set 13 with 374 of 374 items TITLE OR SUBJECT POHER CONSIDERATIONS IN EPIDEMIOLOGIC STUDIES OF VINYL CHLORIDE WORKERS AUTHOR/AFFILIATION BEAUMONT JJjNIOSHjBRESLOH NE,N0NE) ORIGIN AMERICAN J OF EPIDEMIOLOGY>VOL 114 N0.5 PP.725-734) DATE 1981 ABSTRACT NINE RETROSPECTIVE MORTALITY STUDIES OF WORKERS EXPOSED TO VINYL CHLORIDE WERE REVIEWED TO DETERMINE WHETHER DIFFERENCES IN THEIR HYPOTHESIS TESTING RESULTS MIGHT BE DUE TO DIFFERENCES IN STATISTICAL POWER. WHERE POSSIBLE THE POHER OF EACH STUDY HAS CALCULATED FOR CANCER OF THE LUNG* BRAIN AND LIVER. WHEN POHER HAS TAKEN INTO CONSIDERATION, THE RESULTS FOR LIVER AND BRAIN CANCER WERE FOUND TO BE CONSISTENT WITH AN ETXOLOGIC ROLE FOR VINYL CHLORIDE. FOR LUNG CANCER, THE DATA WERE NOT CONSISTENT WITH AN ETIOLOGIC ROLE, IN THAT TWO STUDIES WITH VERY HIGH POHER YIELDED NEGATIVE RESULTS. DESCRIPTORS **xxx VCM)LUNG)CANCER)HUMAN)EFFECTS)EPIDEHIOLOGY) HELD TERMS STATISTICAL POHER) UNIV OF WASHINGTONJ REVIEW YEAR 1992 Item 235 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 1796 GEN BIBLIOGRAPHY THE PHYSIOLOGICAL EFFECTS OF VINYL CHLORIDE AND POLYVINYL CHLORIDE (USERS MANUAL,VOL 1 AND VOL 11) NONE,NONE) NONE,DEVELOPED DATABASE SYSTEM CALLED BOYD DOCUMENT SYSTEM (BDSH 1981 THE FIELD OF OCCUPATIONAL SAFETY AND HEALTH HAS UNDERGONE AN INFORMATION EXPLOSION OVER THE LAST SEVERAL YEARS. THE PVC SAFETY GROUP OF THE SOCIETY OF THE PLASTICS INDUSTRY, INC. (SPI) HAS ASSEMBLED THE LITERATURE ON RELEVANT RESEARCH FINDINGS APPLICABLE TO THE PHYSIOLOGICAL EFFECTS OF VINYL CHLORIDE (VC) AND POLYVINYL CHLORIDE (PVC). THIS INFORMATION IS EASILY ACCESSIBLE AND CAN BE CONVENIENTLY SEARCHED. ANY INTERESTED RESEARCHER, ADMINISTRATOR OR LEGAL REPRESENTATIVE MAY REQUEST A SEARCH OF THIS DATABASE. THE INFORMATION OBTAINED IN THIS DATABASE HILL BE SUPPORTIVE OF RESPONSES TO GOVERNMENT INQUIRY OR ACTIONS,LITIGATION,AN0 COMPARISON OF SCIENTIFIC RESULTS. PVC)VCM)TOXICITY DATA) DANIEL P. BOYD & CO) 1992 Item 236 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT REPORT EVALUATION OF MORTALITY IN BFGOODRICH WORKERS; A FOLLOW-BACK STUDY OF MEDICAL RECORDS AND DEATH CERTIFICATES (FINAL REPORT) NONE,NONE) NONE,FOR BFG) 1974, MAY 17 THIS REPORT (BFGR) SUHARIZES THE RESPONSE OF TABERSHAW/COOPER ASSOCIATES (TCA) TO A REQUEST FROM B.F. GOODRICH COMPANY (BFG) TO TO EVALUATE THE POSSIBLE ROLE OF VINYL CHLORIDE AS A CAUSATIVE AGENT FOR ANGIOSARCOMA OF THE LIVER IN THEIR WORKERS. MUCH OF THE ACTIVITY CENTERED UPON THE LOUISVILLE,KENTUCKY PLANT WHERE CASES OF ANGIOSARCOMA HAD BEEN IDENTIFIED PREVIOUSLY. AN 22521077 % % DATA SEARCH ON VCM/TDXICITY STUDIES FOR CRAIG ELGUT Order nunber 911001-135640-NIZ -001-007 page 78 set 13 with 374 of 374 items DESCRIPTORS HELD TERMS REVIEW YEAR INTERIM REPORT HAS SUBMITTED BY TCA TO BFG ON MARCH 20, 1974. IT SIAWARIZED MEDICAL AND INDUSTRIAL HYGIENE RECOtttENOATIONS, AND PROGRESS IN EPIDEMIOLOGIC STUDIES. VCM)EPIDEMIOLOGYHUMAN)EFFECTS| TABEHSHAH/COOPER ASSOCIATES} 1992 Item 237 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFI LIATIQN ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR REPORT MEDICAL RECORDS AND INDUSTRIAL HYGIENE STUDIES FOR BFG NONE,NONE} NONE,PROGRESS REPORT FOR BFG} 1974, MARCH 20 THIS REPORT DETAILS THE STATUS AS OF MARCH, 1974, OF CONSULTATIVE ACTIVITIES PROVIDED BY TABERSHAH/COOPER ASSOCIATES,INC. TO BFGQODRICH COMPANY WITH RESPECT TO THE MORTALITY AND MORBIDITY ASCRIBED TO THE HANDLING OF VINYL CHLORIDE, ESPECIALLY IN THE BFGOODRICH LOUISVILLE PLANT. RECOMMENDATIONS AND PROPOSALS ARE ADDRESSED. VCM}EPIDEMXOLOGY)HUMAN}EFFECTS} TABERSHAJVCOOPER ASSOCIATES) 1992 Item 236 ACCESSION NUT-CER 1793 FILE LOCATION GEN DOCUMENT TYPE PROCEEDINGS TITLE OR SUBJECT BIRTH DEFECTS AND VINYL CHLORIDE AUTHOR/AFFILIATION EDMONOS,CDC ORIGIN DATE NIOSH,CONFERENCE ON WOMEN AND THE WORKPLACE (WASHINGTON)) 1976, JUNE 17-19 ABSTRACT STATISTICAL COMPARISONS ON DISTANCES VARYING FROM ONE MILE TO 10 MILES OF PARENTAL RESIDENCE TO THE PLANT INDICATED THAT THERE HAS NO DIFFERENCE BETWEEN THE CASES AND CONTROL. DESCRIPTORS ****x VCM)BIRTH DEFECTS)HUMAN)EFFECTS)EPIDEMIOLOGY) REVIEW YEAR 1992 Item 239 ACCESSION NUMBER FILE LOCATION OOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 1792 GEN PUBLICATION VINYL CHLORIDE AND CONGENITAL MALFORMATION NONE,NONE) CDC 1976 IN MARCH 1975, THE OHIO DEPARTMENT OF HEALTH REPORTED AN INCREASED RATE OF CENTRAL NERVOUS SYSTEM (CNS) MALFORMATIONS IN 3 OHIO COWUNITIES WHERE POLYVINYL CHLORIDE (PVC) POLYMERIZATION PLANTS ARE LOCATED (1). THE MALFORMATION RATES HERE DERIVED FROM BIRTH CERTIFICATE DATA FOR 1970-1973 AND HERE COMPAREED WITH SIMILAR DATA FOR THE ENTIRE STATE OF OHIO. THE INCREASE HAS NOT 'A/ /a % DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order number 9110Q1-135640-WIZ -001-007 page 79 set IS with 374 of 374 items UNIFORM IN THE 3 COWJUNITIES AND APPEARED MOST PROMINENT IN PAINESVILLE. DESCRIPTORS ******* VCM)PVC)BIRTH DEFECTS)HUMAN)EFFECTS)EPIDEMIOLOGY| REVIEW YEAR 1992 Item 240 ACCESSION NUMBER 1747 FILE LOCATION GEN DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN REPORT NIOSH STUDIES WHERE INDUSTRY AND/OR OCCUPATIONAL GROUPS ARE INVESTIGATED NONE,NONEv NATIONAL INSTITUTE OF OCCUPATIONAL SAFETY AND HEALTH DATE ABSTRACT 1984 THESE ARE ONE PAGE SUMMARIES OF EPIDEMIOLOGY STUDIES. THEY HAVE BEEN USED BY RALPH NADER TO SHOW CONGRESS EXAMPLES OF INSTANCES WHERE INDUSTRY HAS CONDUCTED RESEARCH BUT HAS NOT NOTIFIED THE WORKERS. DESCRIPTORS xxxxxxx VINYL CHLORIDE MONOMER^EPIDEMIOLOGYiHUMANS^EFFECTS)NATIONAL INSTITUTE OF OCCUPATIONAL SAFETY AND HEALTH) REVIEW YEAR 1990 Item 241 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ****; HELD TERMS REVIEW YEAR 1719 GEN PAPER WORKING CONDITIONS AND MEASURES FOR THEIR SANITATION IN THE PRODUCTION AND UTILIZATION OF VINYL CHLORIDE PLASTICS TRIBUKH SL,NONEvTIKHOMIROVA NPNONE)LEVXN SV,NONE) KOZLOVNONE) ARG SANIT>VOL 10 PP.38-45) 1949 THIS DOCUMENT IS OFTEN QUOTED BY LAWYERS AS EARLY EVIDENCE OF VCM CAUSING LIVER DAMAGE. HOWEVER* OTHER THINGS SUCH AS PCB'S COULD ACCOUNT FOR ILLNESS OBSERVED. VINYL CHLORIDE MONGMER)CANCER)HUHANS)EFFECTS)LXVER> ACADEMY OF MEDICAL SCIENCES (USSR)) 1998 Item 242 ACCESSION NUMBER 1718 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT OCCUPATIONAL HAZARDS OF VINYL CHLORIDE AND STYRENE AUTHOR/AFFILIATION NICHOLSON WJCITY UNIV OF NEW YORK)HENNEBERGER PKSAME) SEXOMAN H,SAKE)TARR D,SAME) ORIGIN NONE,VOL 141 PP.65-78 155-176 263-278) DATE 1984 ABSTRACT ARTICLES PUBLISHED DISCUSS "TRENDS IN CANCER MORTALITY AMONG WORKERS IN THE SYNTHETIC POLYMERS INDUSTRY (PP.65-78) >"OCCUPATIONAL HAZARDS IN THE VC-PVC INDUSTRY (PP.155-176^OCCUPATIONAL HAZARDS IN PRODUCTION OF PROCESSING OF STYRENE POLYMERS--EPIDEMIOLOGIC FINDINGS (PP.263-278).M DESCRIPTORS xx-xxxxx VINYL CHLORIDE MONOMER )STYRENE)CANCER)HUMANS)EFFECTS)EPXDEHXOLOGY) HELD TERMS PROGRESS IN CLINICAL AND BIOLOGICAL RESEARCH) 22321073 % -u 'w*' w' sJ DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order nurber 911001-135640-WIZ -001-007 page 80 set 13 with 374 of 374 items COMMENTS REVIEW YEAR WJ(&5) QUESTIONS THE CLAIM THAT VCM CUASES LUNG CANCER. 1990 Item 243 ACCESSION NUtBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 1711 GEN PUBLICATION GENETIC SUSCEPTIBILITY TO SCLERODERMA-LIKE SYNDROME INDUCED BY VINYL CHLORIDE BLACK CM,NONE)WALKER AE>NONE)CATOGGXO LJ,NONE)HELSH KI,NONE) BERNSTEIN RM,NONE)MCGREGOR AR) JONES JKL,NONE) NONE ,PP53-55) 1983 VINYL CHLORIDE (VC) MONOMER CAN INDUCE A SCLERODERMA-LIKE SYNDROME IN A PROPORTION OF WORKERS EXPOSED TO IT DURING PRODUCTION OF POLYVINYL CHLORIDE. AS PART OF A 5-YEAR FOLLOW-UP STUDY HLAA A, B, AND DR ANTIGENS AND ANTI-CENTROMERE AND ANTI-SCLERODERMA-70 ANTIBODIES HERE DETERMINED IN 44 SUCH WORKERS. 21 OF THESE HAD SEVERE AND 23 MILD FORMS OF VINYL-CHLORIDE DISEASE. 50 PATIENTS HITH "CLASSICAL" SCLERODERMA AND 148 HEALTHY HOSPITAL WORKERS ACTED AS CONTROLS. 11 OF THE 21 PATIENTS CLASSIFIED AS HAVING SEVERE VC DISEASE WERE DR3 POSITIVE,AND 8 OF THESE HAD BOTH B8 AND DR3 ANTIGENS. NONE OF THE 23 PATIENTS WITH MILD DISEASE CARRIED EITHER ANTIGEN. THE HLA-ANTIGEN FREQUENCIES IN VC DISEASE MIRRORED THOSE FOUND IN SCLERODERMA (RAISED DR5 FREQUENCY AND INCREASED LINKAGE DISEQUILIBRIUM BETWEEN B8 AND DR3). THERE HERE ,HONEVER,SXGNXFXCANT DIFFERENCES IN THE FREQUENCY OF AUTOANTIBOOIES IN THE TWO CONDITIONS. SCLERODERMA)VINYL CHLORIDE MONOMER)HUMANS)EFFECTS> THE LANCET)GUY'S HOSPITALCLONDON))HAMiERSMITH HOSPITAL(LONDON)) 1990 Item 244 ACCESSION NUfBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 1703 GEN PUBLICATION HEPATIC ANGIOSARCOMA FROM VINYL CHLORIDE. REPORT OF A NEW ITALIAN CASE CHIAPPINO G,NONE)BERTAZZX PA,NONE)BARONI M,NONE)MASZNX T,NONE) NONE,VOL 6 PP.555-563) 1982 THE FOURTH CASE OF ANGIOSARCOMA OF THE LIVER AMONG WORKERS EXPOSED TO VINYL CHLORIDE IN ITALY IS REPORTED. THE CASE HAS A 43 YEARS OLD MAN WHO WORKED FROM 1959 TO 1980 IN A VCM/PVC PRODUCTION PLANT, MOSTLY IN THE POLYMERIZATION AREA. HE DIED IN MARCH 1981, FOUR MONTHS AFTER DIAGNOSIS,FOR A MASSIVE HAEMOPERITONEUM. POST MORTEM EXAMINATION NAS PERFORMED. ACCORDING TO FOUR INDEPENDENT PATHOLOGISTS THE HISTOLOGIC APPEARANCE NAS TYPICAL OF A HIGHLY DEVIATING ANGIOSARCOMA. THE TUMOR DEVELOPED AFTER A SCLEROTIC LIVER LESIONS WAS ALREAOY PRESENT. THE ANGIOSARCOMA HAS PROBABLY POLYCENTRIC, HAD A HIGH DEGREE OF MALIGNANCY AND A RAPID LOCAL EVOLUTION WHILE,IN CONTRAST, NO METASTASES WERE DETECTED. ANGIOSARCOMA)VINYL CHLORIDE MONOMER)HUMANS)EFFECTS) MED LAVORO) 1990 Item 245 22521080 % DATA SEARCH OH VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order number 911001-135640-HIZ -001-007 page 61 sai 13 with 374 of 374 items ACCESSION NUMBER 1701 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT AUTHOR/AFFILIATION DRUG-INDUCED VASCULAR LESIONS OF THE LIVER ZAFRANI ES,NONE)PINAUDEAU Y>NONEjDHLWEAUX D,N0NE) ORIGIN N0NEVOL 143 PP.495-502) DATE 1963> MARCH ABSTRACT THE VASCULAR LESIONS OF THE LIVER DESCRIBED IN ASSOCIATION WITH ORUG AND TOXIC SUBSTANCE EXPOSURE ARE REVIEHED WITH SPECIAL REFERENCE TO THE ABNORMALITIES OF THE FOLLOWING: 11) THE HEPATIC VENOUS EFFERENT SYSTEM (IE>LARGE AND SMALL HEPATIC VEIN OBSTRUCTION J)< 2) THE SIMJSOIDS (IE,SINUSOIDAL DILATATION, PELIOSIS,PERISINUSOIDAL FIBROSIS)) (3) THE PORTAL VEIN AND ITS BRANCHES) NO (4) THE HEPAITC ARTERIAL TREE. DRUG-INDUCED VASCULAR TUMORS OF THE LIVER AND VASCULAR CHANGES OBSERVED WITHIN NONVASCULAR TUMORS OF THE LIVER ARE ALSO ENVISAGED. FINALLY, THE PATHOPHYSIOLOCIG MECHANISMS OF ALL THESE LESIONS ARE CONSIDERED. THE AHARENESS OF THIS TYPE OF HEPATOTOXICITY AND THE KNOWLEDGE OF ITS EPIDEMIOLOGY SEEM TO BE ESSENTIAL FOR BOTH ITS EARLY DETECTION AND PREVENTION. DESCRIPTORS ******* VINYL CHLORIDE MONOMER)LIVER)EFFECTS)ANGIOSARCOMA) HELD TERMS BUDD-CHIARI SYNDROME)VENO-OCCLUSIVE DISEASE)PEUOSIS HEPATIS) ARCH INTERN MED) REVIEW YEAR 1990 Item 246 ACCESSION NUFBER 1700 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT VINYL CHLORIDE-INDUCED HEPATIC LESIONS IN MAN AND RODENTS. A COMPARISON AUTHOR/AFFILIATION POPPER H,NONE)MALTONI C,N0NE)SELIKOFF IJ,CITY UNIV OF NEW YORK) ORIGIN NONE,VOL 1 PP.7-20) DATE 1981 ABSTRACT HISTOLOGIC SEQUENCES IN THE LIVER OF RODENTS EXPOSED BY INHALATION TO GASEOUS VINYL CHLORIDE MERE COMPARED TO THE LESIONS IN MAN EXPOSED TO THE SAME AGENT, MAINLY IN VINYL CHLORIDE POLYMERIZATION PLANTS. AN IDENTICAL SEQUENCE,STARTING WITH CXRCUMSCRIBEO PROLIFERATION OF HEPATOCYTES,SOON FOLLOWED BY PROLIFERATION OF A VARIETY OF SINUSOIDAL CELLS AND FREQUENTLY ASSOCIATED WITH SINUSOIDAL DILATATION,PROGRESSES TO INTRALOBULAR AND MORE FREQUENTLY TO TRABECULAR ANGIOSARCOMA. PREDOMINANTLY IN YOUNG ANIMALS AND RARELY IN MAN, HEPATOCECCULAR CARCINOMA DEVELOPS, BUT NEVER CIRRHOSIS. THE SEQUENCE REPRESENTS A DYNAMIC PROCESS OF COMPETITION BETWEEN PROLIFERATING HEPATOCYTES AND SINUSOIDAL CELLS, OF HEPATOCYTES WITH FIBROPLASIA.BETWEEN PERISINUSOXDAL FIBROSIS AND SINUSOIDAL DILATATION.AND OF PROLIFERATION OF VARIOUS SINUSOIDAL CELLS VERSUS ANGIOSARCOMA. THE GREAT SIMILARITY IN THE EVOLUTION IN HAN AND RODENTS,RARELY ENCOUNTERED IN OTHER EXPERIMENTAL MODELS, SUPPORTS THE PREDICTION OF HUMAN CANCER FROM ANIMAL EXPERIMENTS. THE PRECURSOR NODULES DIFFER FROM THE NODULES COttONLY OBSERVED IN HEPATOCARCXNOGENESXS BY CO-PROLIFERATION OF SINUSOIDAL CELLS. THE DIFFERENCES IN THE REACTIONS BETWEEN MAN AND RODENTS BESPEAK A STRONG FIBROBLASTIC REACTIVITY IN MAN. MOST IMPORTANT, THE PRECURSOR LESION OF MIXED HEPATOCELLULAR AND SINUSOIDAL CELL PROLIFERATION MAY BE OF DIAGNOSTIC VALUE, BEING SUPERIOR TO CONVENTIONAL HEPATIC TESTS IN DETECTION OF SOME INITIAL ENVIRONMENTAL LESIONS. DESCRIPTORS xxxxxxx VINYL CHLORIDE MONOMER)LIVER)EFFECTS)HUMANS)RAT)PATHOLOGY) MICE) HELD TERMS LIVER PUBLXCATXON)INSTXTUTE OF ONCOLOGY (ITALY))STRATT0N LAB) RODENTS) REVIEW YEAR 1990 DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order nuAer 911001-135690-NIZ -001-007 page 82 set 13 with 379 of 379 items 2252103O' Item 297 ACCESSION NUfBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS REVIEW YEAR Item 298 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR Item 299 ACCESSION NUFBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 1699 GEN JOURNAL THE TOXICITY OF VINYL CHLORIDE AS DETERMINED BY REPEATED EXPOSURE OF LABORATORY ANIMALS TORKELSON TR,D0H CHEMICAL COjOYEN F,SAME)R0HE VKSAME> AMERICAN INDUSTRIAL HYGIENE ASS0CIATI0N,V0L 22 NO.5 PP.359-361) 1961, OCTOBER GROUPS OF LABORATORY ANIMALS HERE EXPOSED REPEATEDLY FOR UP TO SIX MONTHS TO EITHER 500,200,100 OR 50 PPM VINYL CHLORIDE IN AIR. DETECTABLE CHANGES OCCURRED AT ALL BUT THE LOWEST CONCENTRATION THE RESULTS ARE DISCUSSED AND HANDLING PRECAUTIONS SUGGESTED. VINYL CHLORIDE MONQMER)EFFECTS)RAT)RABBIT)GUINEA PIGjSUBACUTE) 1990 1696 GEN JOURNAL PROGRESSION OF VINYL CHLORIDE INDUCED HEPATIC FIBROSIS TO ANGIOSARCOMA OF THE LIVER JONES DB,NONE}SMITH PM,NONE) NONE,VOL 39 PP.306-307) 1982 TWO VINYL CHLORIDE MONOMER (VCH) WORKERS, WHO DEVELOPED NON- CIRRHOTIC PORTAL FIBROSIS AND PORTAL HYPERTENSIONDIED FROM ANGIOSARCOMA OF THE LIVER FIVE AND TEN YEARS LATER RESPECTIVELY, DESPITE WITHDRAWAL FROM OCCUPATIONAL EXPOSURE. HE SUGGEST THAT NON-CIRRHOTIC PORTAL FIBROSIS CAUSED BY EXPOSURE TO VCM IS POTENTIALLY PREMALIGNANT AND THAT THOSE WORKERS MHO ALREADY HAVE THE CONDITION SHOULD BE CAREFULLY MONITORED. HUMANS)EFFECTS)VINYL CHLORIDE MONOMER)LIVER)ANGIOSARCOMA) BRITISH J OF INDUSTRIAL MEDICXNE)LLANDOUGH HOSPITAL (UK)) 1990 1691 GEN PUBLICATION CARCINOGENICITY AND EPXOEMXOLOGXCAL PROFILE ANALYSIS OF VINYL CHLORIDE AND POLYVINYL CHLORIDE KALMAZ EE,UNIVERSITY OF TEXASiKALHAZ GD,NONE) NONE,VOL 9 PP.13-27) 1989 THIS IS A VERY BAD REVIEW OF THE CARCINOGENICITY/EPIDEMIOLOGY DATA ON VCM/PVC. CONSIDERATION NAS GIVEN TO HAVING PATRICIA BUFFLER AND MARCUS KEY DO A CRITIQUE,BUT THEIR TRIP TO CHINA PUT THIS ON HOLD IN DEFINITELY. POLYVINYL CHLORIDE)VINYL CHL0RI0E MONOMER)CANCER)HUNANS)EFFECTS)EPIDEMIOLOGY) REGULATORY TOXICOLOGY ft PHARMACOLOGY) UNIV OF TEMESSEE) 1990 %% DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order number 911001-135640-HIZ -001-007 page 63 set 13 with 374 of 374 items Item 250 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** COMMENTS REVIEW YEAR 1690 GEN PAPER VINYL CHLORIDE EXPOSURE AND ANGIOSARCOMA OF THE LIVER-- A REPORT OF THE ICI REGISTER OF CASES DOLL SIR RICHARD N0NE> NONE,NONE) 1984 THE AUTHORS PREOICT ANOTHER 150-200 DEATHS FROM VCM RELATED ANGIOSARCOMA. THIS PROJECT IS BEING SUPPORTED BY SPI. VINYL CHLORIDE MONOMER )ANGIQSARCOMA)HUMANS) EFFECTS {EPIDEMIOLOGY ) RKHI85) DRAFT OF AN ARTICLE TO BE PUBLISHED 1987 Item 251 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** REVIEW YEAR 1689 GEN PUBLICATION VINYL CHLORIDE: A CANCER CASE STUDY PURCHASE IFHNONE)STAFFORD J,NONE)PADDLE GM,NONE> NONE,NONEl 1964 VINYL CHLORIDE MONOMER)CANCER)ANGIOSARCOMA)HUMANS)EFFECTS)RISK ASSESSMENT ^EPIDEMIOLOGY } 1987 Item 252 ACCESSION NUtttER FILE LOCATION 1686 GEN . 'v DOCUMENT TYPE JOURNAL TITLE OR SUBJECT INCIDENCE OF CANCER AMONG VINYL CHLORIDE AND POLYVINYL CHLORIDE WORKERS AUTHOR/AFFILIATION HELDAAS SSNONE)LANGARD SL,NONE)ANDERSEN A>NONE) ORIGIN DATE ABSTRACT NONE.yOL 41 PP.25-30) 1984 THE RESULTS OF A FOLLOW UP STUDY OF THE INCIDENCE OF CANCER AND THE MORTALITY IN A COHORT OF 454 MALE WORKERS PRODUCING VINYL CHLORIDE AND POLYVINYL CHLORIDE ARE PRESENTED. THE STUDY POPULATION HAS REESTRICTED TO EMPLOYEES WITH MORE THAN ONE YEAR'S WORK EXPERIENCE IN THE STUDY PLANT BETWEEN 1950 AND 1969 AND THE COHORT HAS FOLLOWED UP FROM 1953 TO THE END OF 1979. TWENTY THREE NEW CASES OF CANCER HERE OBSERVED COMPARED WITH 20-2 EXPECTED)ONE CASE OF LIVER ANGIOSARCOMA HAS FOUND. FIVE CASES OF LUNG CANCER HERE FOUND (2.8 EXPECTED) AND FOUR CASES OF MALIGNANT MELANOMA OF THE SKIN HERE OBSERVED (0-6 EXPECTED). THE POSSIBILITY OF A CAUSAL RELATIONSHIP BETWEEN EXPOSURE TO VINYL CHLORIDE AND THE DEVELOPMENT OF MALIGNANT MELANOMAS IS DISCUSSED. DESCRIPTORS xxxxmtx VINYL CHLORIDE MONOMER)POLYVINYL CHLORIDE)HUMANS)EFFECTS)EPIDEM10LOGY) CANCER) HELD TERMS BRITISH J OF INDUSTRIAL MEDICINE) MELANOMAS REVIEW YEAR 1990 321083 % OATA SEARCH ON VCh/TOXICITY STUDIES FOR CRAIG ELGUT Order muter 911001-135640-HIZ -001-007 page 69 set 13 with 374 of 379 items Item 253 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS KWHtxxx HELD TERMS REVIEN YEAR 1687 GEN JOURNAL VINYL CHLORIDE: THE EVIDENCE FOR HUMAN CARCINOGENICITY IN DIFFERENT TARGET ORGANS SALMON AG,NONE> NONE,VOL 42 NO.2PP.73-741 1985, FEBRUARY VINYL CHLORIDE MONOMERlPOLYVINYL CHLORIDE {ETHYLENE DZCHL0RIDE|CANCER)EFFECTS{HU1ANS{EPIDEHI0L0GY{ BRITISH J OF INDUSTRIAL MEDICINE{ 1995 Item 254 ACCESSION NUMBER 1645 FILE LOCATION GEN DOCUMENT TYPE TECHNICAL REPORT TITLE OR SUBJECT VCM FROM PVC DURING THERMAL DECOMPOSITION AUTHOR/AFFILIATION NONE,NONE) ORIGIN UNION CARBIDE DATE 1975 DESCRIPTORS xxxxx: VCM) PVC) HELD TERMS FRA6MENT0GRAPHY) tk KHIC INDEX NUMBER REVIEN YEAR 00713REPO 1990 Item 255 ACCESSION NUMBER 1374 FILE LOCATION GEN DOCUMENT TYPE EPA REPORT TITLE OR SUBJECT ASSOCIATION BETWEEN BIRTH DEFECTS AND EXPOSURE TO AMBIENT VINYL CHLORIDE AUTHOR/AFFILIATION THERIAULT GP,NONE)ITURRA HN0NE{GINGRAS SNONE> ORIGIN EPA,REPORT NO. EPA 600/1-81-057) DATE 1981, AUGUST ABSTRACT SHANINIGAN HAD AN EXCESS OF BIRTH DEFECTS WHICH FLUCTUATED SEASONALLY IN A HAY THAT COULD CORRESPOND TO CHANGES IN VCM CONCENTRATION IN THE ENVIROMENT. MOTHERS MHO GAVE BIRTH TO MALFORMED CHILDREN HERE YOUNGER ON AVERAGE IN SHANINIGAN THAN IN THE COMPARISON COMMUNITIES* HOWEVER, THERE HAS NO EXCESS OF STILLBIRTHS IN SHANINIGAN, THE EXCESS OF BIRTH DEFECTS INVOLVED MOST SYSTEMS, AND VARIATION IN BIRTH-DEFECT RATES AMONG SCHOOL DISTRICTS COULD NOT BE ACCOUNTED FOR BY ESTIMATES OF VCM IN THE ATMOSPHERE. THE OCCUPATIONAL AND RESIDENTIAL HISTORIES OF PARENTS WHO GAVE BIRTH TO MALFORMED INFANTS HERE COMPARED WITH THOSE OF PARENTS OF NORMAL INFANTS. THE TWO GROUPS DID NOT DIFFER IN OCCUPATIONAL EXPOSURE OR CLOSENESS OF RESIDENCE TO THE VINYL CHLORIDE POLYMERIZATION PLANT. DESCRIPTORS xxxxxxx VCM*BIRTH DEFECTS)HUMANiEPIDEMIOLOGY{EFFECTS) HELD TERMS LAVAL UNIV) REVIEW YEAR 1991 MU. % O 6 DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order nunber 911001-135640-KIZ -001-007 page OS set 13 with 374 of 374 items Item 256 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS REYIEH YEAR 1370 GEN PUBLICATION PRENATAL SUSCEPTIBILITY TO CARCINOGENESIS BY XENOBIOTXC SUBSTANCES INCLUDING VINYL CHLORIDE RICE JMNCl! ENVIRONMENTAL HEALTH PERSPECTIVES,VOL 41 PP.179-188) 1981, OCTOBER THE CARCINOGENICITY OF VINYL CHLORIDE FOR EXPERIMENTAL ANIMALS HHEN ADMINISTERED TRANSPLACENTALLY IS REVIEWED IN COMPARISON KITH KNOW TRANSPLACENTAL CARCINOGENS, INCLUDING THOSE THAT, LIKE VINYL CHLORIDE, ARE DEPENDENT ON ENZYME-MEDIATED METABOLIC CONVERSION TO A REACTIVE INTERMEDIATE IN MATERNAL OR FETAL TISSUES. VINYL CHLORIDE IS CONVERTED BY MIXED-FUNCTION OXIDASES TO THE REEACTIVE METABOLITE CHLOROOXIRANE,THE CARCINOGENICITY OF WHICH IS ALSO REVIEWED. VINYL CHLORIDE IS UNEQUIVOCALLY A TRANSPLACENTAL CARCINOGEN FOR THE RAT. NO EVIDENCE EXISTS, HOWEVER, TO SUPPORT THE HYPOTHESIS THAT EXPOSURE OF HALE RATS TO VINYL CHLORIDE OR ANY OTHER CARCINOGEN CONFERS AN INCREASED RISK OF TUMOR DEVELOPMENT ON THEIR PROGENY. MANY STRUCTURAL ANALOGS OF VINYL CHLORIDE, I.E., SUBSTITUTED ETHYLENES, ARE ALSO CARCINOGENIC FOR ADULT ANIMALS, AND CAN WITH CONFIDENCE LIKENISE BE PREDICTED TO BE EFFECTIVE TRANSPLACENTAL CARCINOGENS. ALSO REFER TO AN13664 (PAPER/KWIC 04589). TRANSPLACENTAL CARCINOGEN)VCM>FETAL TOXICITY>RAT} CARCINOGENICITY! 1991 Item 257 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS xxxxxxx REVIEW YEAR 1367 GEN PUBLICATION SCIENTIFIC AND TECHNICAL ASSESSMENT REPORT ON VINYL CHLORIDE AND POLYVINYL CHLORIDE NONE,NONE! EPA,600/6-75-004) 1975, JUNE PVC lVCMJHUMAN^EFFECTS*ANALYSISJRISK ASSESSMENHEMISSIONS! 1990 Item 258 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN OATE ABSTRACT 1366 GEN PUBLICATION INFLUENCE OF EXPOSURE MODE ON VINYL CHLORIDE ACTION JEDRYCHOHSKI RANONEiSOKAL JA,NONE!CHMXELNICKA J,NONE> ARCH TOXICOL,VOL 55 PP.195-198! 1984 RATS WERE SUBJECTED TO 4 HOURS CONTINUOUS OR INTERMITTENT EXPOSURE TO VINYL CHLORIDE (VC) AT DIFFERENT TIME-WEIGHTED AVERAGE CONCENTRATIONS (15,50,150,500 AND 15,000 HG/M3). AT AVERAGE CONCENTRATIONS OF 50 MG/M3 AND 150 MG/M3, THE URINARY EXCRETION OF TOGA UNDER CONTINUOUS EXPOSURE DID NOT DIFFER FROM THAT UNDER INTERMITTENT EXPOSURE,WHEREAS AT VC CONCENTRATIONS OF 500 MG/M3 AND 15,000 MG/M3 IT NAS HIGHER FOLLOWING CONTINUOUS EXPOSURE. DATA SEARCH ON VCM/TCKICITY STUDIES FOR CRAIG ELGUT Order number 911001-135640-HIZ -001-007 page 86 set 13 Kith 374 of 374 items DESCRIPTORS HELD TERMS REVIEW YEAR xxxxxxx VCMiRATS)INHALATION)METABOLISM)EFFECTS> MEDICAL ACADEMY (POLAND)) 1991 Item 259 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** HELD TERMS REVIEW YEAR 1365 GEN PUBLICATION EXPERIMENTAL CONTRIBUTIONS IN IDENTIFYING BRAIN POTENTIAL CARCINOGENS IN THE PETROCHEMICAL INDUSTRY MALTONI CNONE>CILIBERTX ANONE)CARRETTI DN0NE) ANNALS OF THE NEW YORK ACADEMY OF SCIENCES,PP.216-249) 1982 CARCINOGENICITY)BRAIN)T\JMORS)EFFECTS)VCM)ACRYLONITRILE)BIS-CHLOROMETHYL ETHER)HYDRAZINE>TRIAZINE) AROMATIC HYDROCARBONS)NITROSOUREAS)INSTITUTE OF ONCOLOGY (ITALY)) 1991 Item 260 ACCESSION NUt-BER 1364 FILE LOCATION GEN DOCUMENT TYPE REPORT TITLE OR SUBJECT THE 19S5-1959 U.S. MORTALITY TABLES FOR AGE 85 AND OVER AUTHOR/AFFILIATION ARMSTRONG B>NONE)GREEWURG DNQNE) ORIGIN NONE DATE 1978, JUNE ABSTRACT MORTALITY TABLES FOR U.S. POPULATION. USED FOR RISK ASSESSMENT OF VCM FOR THE CALIFORNIA AtBIENT AIR STANDARD. DESCRIPTORS xxxxxxx VCMiRISK ASSESSMENT)MORTALITY) HELD TERMS U.S.BUREAU OF VITAL STATISTICS) STATISTICS) REVIEW YEAR 1990 Item 261 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 1363 GEN PUBLICATION THE EFFETS OF ORGANIC COMPOUNDS USED IN THE MANUFACTURE OF PLASTICS ON THE RESPONSIVXTY OF MURINE AND HUMAN LYMPHOCYTES THURMAN GB,UNIV OF TEXAS)SIMMS BG,SAME)GOLOSTEIN AL,SAME)KILIAN DJSAME) TOX ANO APPLIED,VOL 44 PP.617-641) 1978 THE EFFECTS OF ACUTE EXPOSURE TO A NUMBER OF INDUSTRIALLY IMPORTANT ORGANIC COMPOUNDS ON THE ItflUNOLOGICAL RESPONSES OF HUMAN AND MURINE LYMPHOCYTES HERE STUDIED. THE COMPOUNDS HERE BENZENE, 1-4-DIOXANE, TOLUENE DIISOCYANATE (TDI),VINYL CHLORIDE ,ETHYLENIMXNE> AND EPICHLOROHYDRZN. CONTROL COMPOUNDS KNOW TO HAVE IMMUNOLOGICAL EFFECTS WERE AZOTHXOPRINE, HYDROCORTISONE ACETATE, AND TRIETHYLENE MELAMINE ITEM). THE UPTAKE OF TRITIATEO THYMIDINE ((3H)TDR) OF LYMPHOCYTES HAS USED TO MEASURE THEIR ABILITY TO RESPOND TO MITOGENIC AGENTS, ALLOGENEIC LYMPHOCYTES, OR THE ANTIGENIC NATURE OF THE COMPOUNDS THEMSELVES. MOST OF THE COMPOUNDS HERE FOUNO TO BE CYTOTOXIC TO jr* & <b % DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order number 911001-135640-HIZ -001-007 page 87 set 13 with 374 of 374 items DESCRIPTORS HELD TERMS REVIEW YEAR LYMPHOCYTES AT HIGH CONCENTRATIONS. DIOXANE AND TDI SHOWED EVIDENCE OF SPECIFIC ACTIONS ON THE IMiUNOLOGICAL SYSTEM. DIOXANE SUPPRESSED T-CELL RESPONSES WHILE AUGMENTING D-CELL RESPONSES. TDI EXHIBITED STIMULATORY EFFECTS AT SEVERAL CONCENTRATIONS TO BOTH HUNAN AND MURINE LYMPHOCYTES. THESE FINDINGS INDICATE THAT OF THE CHEMICALS STUDIED* DOTH DIOXANE AND TDI HAVE PROPERTIES WHICH MAKE THEM CAPABLE OF AFFECTING LYMPHOCYTES IN HAYS OTHER THAN NONSPECIFIC CYTOXICITY. THESE PROPERTIES MAKE TDI AND DIOXANE ESPECIALLY INTERESTING WHEN MONITORING IMIUNOLOGICAL SYSTEMS OF INDUSTRIAL WORKERS WHO HAVE BEEN ACCIDENTALLY EXPOSED TO THESE COMPOUNDS AT HIGH CONCENTRATIONS OR WHO ARE ROUTINELY EXPOSED TO MINIMAL LEVELS OF THESE COMPOUNDS. ******* BENZENETDIVCM*VDC1,4-DI0XANE*EPIIN VITRO*LYMPHOCYTESiEFFECTS* ETHYLENIMINElIMIUNOLOGIC EFFECT* CYTOTOXICITY* 1990 Item 262 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS REVIEW YEAR 1362 GEN PUBLICATION MITOCHONDRIAL CHANGES IN HEPATOCYTES OF RATS CHRONICALLY EXPOSED TO VINYL CHLORIDE AND ETHANOL MILLER ML,UNIV OF CINCINNATI*RADIKE MJ>SAME*ANDRINGA A,SAME *BINGHAM E> SAME* ENVIRONMENTAL RESEARCH*VOL 29 PP.272-279* 1982 CHRONIC EXPOSURE OF MALE RATS TO 600 PPM VINYL CHLORIDE <VC) OR VC AND 5Z ETHANOL (ETOH) IN DRINKING HATER INDUCED ULTRASTRUCTURAL CHANGES IN THE MITOCHONDRIA OF HEPATOCYTES. AFTER 6 MONTHS OF VC/ETOH TREATMENT* HEPATOCYTE MITOCHONDRIA OFTEN CONTAINED RIGID TUBULAR PARALLEL CRISTAE AND DILATED CRISTAE WITH DENSE XNCLUSIONS*ETHANOL INGESTION ALONE DID NOT INDUCE THESE MORPHOLOGICAL CHANGES. IN ANIMALS RECEIVING VC ALONE* LARGE FLOCCULAR DENSITIES IN THE MITOCHONDRIAL MATRIX HERE SEEN OCCASIONALLY AFTER 6 MONTHS OF VC INHALATION. THE NUMBERS AND SEVERITY OF CHANGES IN MITOCHONDRIA INCREASED WITH DURATION OF EXPOSURE AND AGE. THE GREATEST RESPONSES OBSERVED IN MITOCHONDRIA OCCURRED WITH THE COtCINED TREATMENT OF VC/ETOH. VCM*LIVER*RATS*ALCOHOL*DRIFKING HATER*EFFECTS)CHRONIC* 1990 Item 263 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE 1361 GEN PUBLICATION TITLE OR SUBJECT EFFECTS OF IWUCERS ON THE IN VIVO COVALENT BINDING OF A VINYL CHLORIDE METABOLITE TO LIVER FRACTIONS AUTHOR/AFFILIATION ORIGIN PESSAYRE D*NONE(NANDSCHEER JC>NONE*DESCATOXRE V>NONE*BOLDER A,NONE* BENKAMOU JP.NONE* BIOCHEMICAL PHARMACOLOGY*VOL 28 PP.3667-3668* DATE 1979 DESCRIPTORS ******* VCMMETABGLISM*COVALENT BXNDING)XN VIVO*RATS)EFFECTS* REVIEH YEAR 1990 Item 264 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE CORR /w r' -J> fttf % DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order number 911001-135640-WIZ -001-007 page 88 set 13 with 374 of 374 items TITLE OR SUBJECT PROCEDURES FOR THE DETERMINATION OF VCM IN PACIFIERS AUTHOR/AFFILIATION O'KARA MM,BFG) ORIGIN BFG-CHEMICAL,TO VINYL INSTITUTE) DATE ABSTRACT 1985, JANUARY 28 THO DIFFERENT LABORATORIES MERE ASKED TO DEVELOP AND CONDUCT EXTRACTION TESTS TO DETERMINE THE AMOUNT OF VCM THAT MIGRATE FROM PVC PACIFIERS. NINE OF TEN TESTS SHOWED THAT NO VCM (LESS THAN 50 PPT) MIGRATES INTO A SALIVA SIMULANT, WHILE THE TENTH SHOWED 120 PPT. BASED ON SAMPLE WEIGHT AND SALIVA SIMULANT WEIGHT, THE 120 PPT VALUE IN THE SALIVA IS EQUIVALENT TO 0.0033 UG, WHICH IS BELOW THE FDA ACCEPTABLE DAILY INTAKE OF 0.011 UG. DESCRIPTORS xkhxxmi* VCM>PVC^MIGRATION*EXTRACTION* HELD TERMS PACIFIERS) REVIEW YEAR 1992 Item 265 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS *******t HELD TERMS REVIEW YEAR 1359 GEN PUBLICATION RISK ASSESSMENT OF EXPOSURE TO VINYL CHLORIDE STOTT WT.DOH CHEMICAL COlNATANABE PG,SAME> NONE,VOL 53 PP.593-595) 1981 VCM)RISK ASSESSMENT)HUMAN)EFFECTS)CARCXNOGENXCITY) PURE & APPL CHEM) 1991 Item 266 ACCESSION NUtBER 1357 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT EPIDEMIOLOGIC CONSIDERATIONS IN THE DESIGN OF TOXICOLOGIC STUDIES: AN APPROACH TO RISK ASSESSMENT IN HUMANS AUTHOR/AFFILIATION WOODS JSNIH) ORIGIN NONE,VOL 38 NO.5 PP.1892-1896) DATE 1979, APRIL ABSTRACT THIS PAPER DESCRIBES A SIX-STEP PROCEDURE FOR INCLUDING EPIDEMIOLOGIC CONSIDERATIONS IN BOTH THE DESIGN AND ANALYSIS OF LABORATORY TOXICITY STUDIES CONDUCTED TO ESTIMATE RISK OF TOXICITY IN HUMANS DURING LOW-LEVEL EXPOSURE TO CHEMICALS IN THE ENVIRONMENT. DESCRIPTORS ******** RISK ASSESSMENT)EPIDEMIOLOGY)VCM)HUMAN)EFFECTS)CARCINOGENICITY) HELD TERMS FEDERATION PROCEEDINGS) REVIEH YEAR 1991 Item 267 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION 1356 GEN PUBLICATION ONCOGENIC AND MUTAGENIC RISKS IN COMUNmES WITH POLYVINYL CHLORIDE PRODUCTION FACILITIES INFANTE PF,N0NE) <3\ c* \P o gSX . 0 w Sm* Q 9 _ m mw < 0 DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order nuiber 911001-135640-HIZ -001-007 page 89 set 13 with 374 of 374 items ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 1976 AN EXCESS NUtfeER OF BIRTH DEFECTS NAS REPORTED FOR COMMUNITIES WITH PVC PRODUCTION FACILITIES. THIS WORK HAS BEEN CRITIZED AS "EPIDEMIOLOGIC GERRYMANDERING". SEE THE REVIEN (KHXC 03648) BY BRIAN MAC MAHON,HARVARD. ALSO REFER TO AN2201<KWIC 01433) INFANTE'S PAPER. ** VCM)PVC)BIRTH DEFECTS|HUMANEFFECTSEPIDEMIOLOGY) OHIO DEPT OF HEALTH* 1991 Item 268 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS xxxxxxx REVIEW YEAR 1348 GEN REPORT CALCULATIONS OF THE AMOUNT OF VCM METABOLIZED AT VARIOUS CONCENTRATIONS HINDERER RK,BFGj BFG 1978 VCM(METABOLISM) 1990 Item 269 ACCESSION NUMBER 1344 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT BIOCHEMICAL ALTERATIONS IN LIVERS OF RATS EXPOSED TO VINYL CHLORIDE AUTHOR/AFFILIATION DU JTUNIV OF LOUISVILLE)SANDOZ JP,SAME)TSENG MT,SAMEjTAMBURRO CH,$AME ORIGIN DATE J OF TOXICOLOGY AND ENVIR0M1ENTAL HEALTH,VOL 5 PP. 1119-1132* 1979 ABSTRACT SPRAGUE-DAHLEY RATS HERE EXPOSED TO VINYL CHLORIDE TO DETERMINE THE EARLIEST SEQUENTIAL BIOCHEMICAL CHANGES OCCURRING WITH LIVER INJURY BEFORE ANGIOSARCOMA DEVELOPMENT.THERE HERE NO CHANGES IN SEVEN CONVENTIONAL CLINICAL BIOCHEMICAL LIVER TESTS OR IN FOUR OTHER MARKERS OF LIVER MITOCHONDRIAL, CYTOSOL* AND MICROSOMAL FUNCITON. NO SIGNIFICANT HISTOLOGICAL CHANGES HERE FOUND ON LIGHT MICROSCOPIC EXAMINATION DURING THIS EXPOSURE PERIOD. HOMEVER* KITH ELECTRON MICROSCOPY* DILATION OF ROUGH ENDOPLASMIC RETICULUM NAS SEEN IN THE ANIMALS EXPOSED FOR MORE THAN 137 HRS. DESCRIPTORS mkxsxkk VCM}LIVER>RATSANGXOSARCOMA REVIEW YEAR 1990 Item 270 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 1343 GEN PUBLICATION NEOPLASTIC RISK AMONG WORKERS EXPOSED TO VINYL CHLORIDE HAXWEILER RJ,NIQSHjSTRINGER WSAMEIWAGONER JK,SAMEJONES J,SAME> FALK H*CDC)CARTER C,SAME> ANNALS OF THE NEW YORK ACADEMY OF SCIENCES,PP.40-48) 1978 IN THE PRESENT STUDY OF WORKERS EXPOSEO TO VINYL CHLORIDE, AN EXCESSIVE NUtCER OF DEATHS DUE TO CANCER OF THE SAME FOUR SITES HAS FOUND, VIZ THE LIVER,LUNG,AND THE LYMPHATIC AND CENTRAL NERVOUS % % O % DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order mjrf>er 911001-135640-HIZ -001-007 page 90 set 13 with 374 of 374 items DESCRIPTORS REVIEW YEAR SYSTEM. THE EVIDENCE, BOTH EPIDEMIOLOGICALLY AND HISTOPATHOLOGICALLY POINTS TO VINYL CHLORIDE AS THE CAUSAL AGENT IN THE ETIOLOGY OF SUCH EXCESSIVE CANCER RISK. THE OBSERVATION OF THE CARCINOGENICITY OF VINYL CHLORIDE* FIRST IN ANIMALS AND SUBSEQUENTLY IN MAN* STRONGLY SUPPORTS THE NEED FOR CONDUCTING ANIMAL BIOASSAY PRIOR TO INTRODUCTION OF CHEMICAL AND OTHER AGENTS INTO THE INDUSTRIAL OR COtMJNITY ENVIRONS.SEE ALSO KMIC04825 (PAPER). xxxxxxx VCM)HUMAN)EFFECTS)CARCINOGENICXTY)EPXDEMXOLOGY) 1991 Item 271 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS xxxxx] HELD TERMS REVIEW YEAR 1311 GEN REPORT EPIDEMIOLOGICAL STUDY OF VINYL CHLORIDE WORKERS ;FINAL REPORT. NONE,NONE) NONE 1978* JANUARY EPIDEMIOLOGY STUDY OF U.S. VCM/PVC WORKERS SHOWS INCREASE IN CARDIOVASCULAR AND RENAL DISEASE. THIS STUDY SUPPORTS THE HYPOTHESIS THAT VCM CAUSES LIVER*LUNG AND BRAIN CANCER. VCM)PVC)HUMAN)EFFECTS)EPIDEMIOLOGY) EQUITABLE ENVIRONMENTAL HEALTH INC) 1990 Item 272 ACCESSION NUfBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** HELD TERMS REVIEW YEAR 1310 GEN REPORT EPIDEMIOLOGIC STUDY OF VINYL CHLORIDE WORKERS EMPLOYED BY UNION CARBIDE CORPORATION,SOUTH CHARLESTON PLANT NONE,NONE) NONE*FOR UNION CARBIDE CORP) 1976, DECEMBER VCM)HUMAN)EFFECTS)EPIOEMIOLOGY> EQUITABLE ENVIRONMENTAL HEALTH INC) 1990 Item 273 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** REVIEW YEAR 1309 GEN PUBLICATION RESULTS OF PROSPECTIVE MORTALITY STUDY ON HUMANS EXPOSED TO VC/PVC FRENTZEL-BEYME VR,N0NE)SCHMITZ T>N0NEITHIESS AM*NONE) NONE,NONE) 1978, OCTOBER PVC)VCM)HUMAN)EFFECTS>EPXDEMIOLOGY) 1991 q\ \n o DATA SEARCH ON YCM/TOXICITY STUDIES FOR CRAIG ELGUT Order nurfaer 911001-135640-HIZ -001-007 page 91 set IS with 374 of 374 itees 22531091 Item 274 ACCESSION NUtBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS **** HELD TERMS REVIEW YEAR 1308 GEN PUBLICATION CONTEMPORARY PEST CONTROL PRACTICES AND PROSPECTS - VOL 1 CARCINOGENESIS IN HAN AND LABORATORY ANIMALS NONE,NONE} NONE 197S STATEMENT MADE KITH REFERENCE TO VCM THAT ANIMALS OVERESTIMATE RISK OF CANCER. VCM}E FFECTS jCARCINOGENICITY> RODENTS} NATIONAL ACADEMY OF SCIENCES}NAS} 1991 Item 275 ACCESSION NUFBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS REVIEW YEAR 1304 GEN PAPER AN EPIDEMIOLOGIC INVESTIGATION OF LUNG CANCER IN A MULTIXENOBIOTIC OCCUPATIONAL ENVIRONMENT HAXWEILER RJ,UNIV OF NORTH CAROLINA} UNIV OF NORTH CAROLINA 1978 AN EXCESS LUNG CANCER RISK (39 OBSERVED AND 27 EXPECTED) NAS OBSERVED AMONG A COHORT OF 4806 MALES EMPLOYED AT A SYNTHETIC CHEMICAL PLANT SINCE IT OPENED IN 1942. UPON REVIEW OF THE PATHOLOGIC MATERIAL, THE EXCESS HAS FOUND TO BE LIMITED TO ADENOCARCINOMA AND LARGE CELL UNDIFFERENTIATED LUNG CANCER. MANY OF THE WORKERS WERE EXPOSED TO VINYL CHLORIDE, BUT OTHER EXPOSURES INCLUDING CHLORINATED SOLVENTS, POLYVINYL CHLORIDE (PVC) DUST, ACRYLATES, AND ACRYLONITRILE EXISTED. THUS, DETAILED WORK HISTORIES OF EACH COHORT MEMBER ALONG WITH EXPOSURE RATINGS OF EACH JOB FOR EACH CALENDAR YEAR SINCE 1942 FOR EACH OF NINETEEN DIFFERENT CHEMICALS (OR CHEMICAL GROUPS) HERE OBTAINED. A SERIALLY ADDITIVE EXPECTED DOSE MODEL HAS CONSTRUCTED WHICH COMPARED THE DOSES OF THE CHEMICALS OBSERVED FOR THE LUNG CANCER CASES TO THE DOSES EXPECTED BASED ON SUBCOHORTS INDIVIDUALLY MATCHED TO THE CASES. PVC DUST APPEARED TO BE THE MOST LIKELY ETIOLOGIC AGENT. OBSERVED AND EXPECTED DOSES HERE THEN ANALYZED BY YEAR BEFORE DEATH TO UNCOVER THE RELEVANT LATENT PERIOD. PVC DUST)VCM }LUNG>CARCINOGENICITY}EPIDEMIOLOGY>HUMAN}EFFECTS} 1991 Item 276 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 1293 GEN REPORT THE MEDICAL COMMISSION ON THE PRODUCTION OF PVC. NONE,NONE} NONE,NONE} 1974, DECEMBER HE CONSIDER IT AN ESTABLISHED FACT THAT VINYL CHLORIDE CAN CAUSE CANCER IN HUMANS. NO HUMAN $ % o \y DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Orcier nuiber 911001-135640-HIZ -001-007 page 92 set 13 with 374 of 374 items DESCRIPTORS HELD TERMS REVIEW YEAR ACTIVITY, JOB OR HABIT IS WITHOUT SOME RISK* AND HE SHOULD AVOID SETTING UP RULES OR OPINIONS WHICH WOULD ONLY SERVE TO EXCHANGE ONE KIND OF HAZARD FOR ANOTHER OF POSSIBLY GREATER DIMENSION. xxxxxxx VCM)CANCER)HUMAN{EFFECTS ) NORSK HYDRO (NORWAY) 1990 Item 277 ACCESSION NUTOER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS xxxxx: HELD TERMS REVIEW YEAR 1292 GEN REPORT PRELIMINARY REPORT ON THE MEDICAL EXAMINATION OF 286 EMPLOYEES AT THE PVC PLANT* NORSK HYDRO A.S, PORSGRUNN FABRIKKER HILLESTAD L,N0NEi NONE,NONE) 1975, JANUARY 31 CHROMOSOMAL ABERRATIONS SEEN IN VCM/PVC WORKERS. VCM) PVC ^CHROMOSOMAL ABERRATION)CARCINOGENICITY)HUMAN)EFFECTS> MUTAGENICITY) NORSK HYDRO (NORWAY) 1990 Item 278 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS xxxxx} REVIEW YEAR 1291 GEN PUBLICATION OCCUPATIONAL ACROOSTEOLYSIS III. A CLINICAL STUDY DODSON VN,NONEJDIM1AN BD,N0NE)KHITEHOUSE W1,N0NE)NASR AHM*NQNE) MAGNUSGN HJNONE) ARCH ENVIRON HEALTHVOL 22) 1971* JANUARY ACROOSTEOLYSIS)VCH)HUMAN)EFFECTS) 1990 Item 279 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT ALTTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS xxxxxxx REVIEW YEAR 1290 GEN PUBLICATION OCCUPATIONAL ACROOSTEOLYSIS II. AN INDUSTRIAL HYGIENE STUDY COOK HANONE)GIEVER PM,N0NE)DIM1AN BD*NONE)MAGNUSON HJ*N0NE) ARCH ENVIRON HEALTH,VOL 22) 1971, JANUARY ACROOSTEOLYSIS)HUMAN)EFFECTS)VCM) 1990 Item 280 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE 1269 GEN PUBLICATION rro* Cl g\ o i DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order nunber 911001-135640-HIZ -001-007 page 93 set 13 with 374 of 374 items TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** REVIEW YEAR OCCUPATIONAL ACROOSTEOLYSIS: I. AN EPIDEMIOLOGICAL STUDY DINMAN BD,NONEJCOOK HA,NONE)HHITEHOUSE 1,NONEjMAGNUSON HJ,N0NE* DITCHECK T,N0NE) ARCH ENVIRON HEALTH,VOL 22) 1971, JANUARY ACROOSTEOLYSXS)VCM)EPIDEMXOLOGY)HUMAN)EFFECTS) 1990 Item 281 ACCESSION NUFCER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS REVIEW YEAR 1287 GEN PAPER VINYL CHLORIDE CONTENT OF SUBCUTANEOUS ADIPOSE TISSUE FROM VINYL CHLORIDE POLYMERIZATION WORKERS KNITTLE JL,C1TY UNIV OF NEW YORK)FONTANARES P,SAME)DAUH S,SAMEjSELIKOFF IJ, SAME) NONE 1974, OECEMBER SIGNIFICANT LEVELS OF VINYL CHLORIDE MONOMER HERE FOUND IN SUBCUTANEOUS FAT DEPOTS OF WORKERS EXPOSED TO THE GAS DURING THE MANUFACTURE OF POLYVINYL CHLORIDE. THE COMPOUND HAS NOT DETECTED IN A CONTROL GROUP OF UNEXPOSED WORKERS. VCM > E FFECTS)HUMAN)FAT) 1990 Item 262 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** REVIEW YEAR 1278 GEN GUIDELINES VINYL CHLORIDE :CODE OF PRACTICE FOR HEALTH PRECAUTIONS NONE,NONE) HEALTH AND SAFETY EXECUTIVE,PP.1-41) 1975, FEBRUARY VCM) 1990 Item 283 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** REVIEW YEAR 1277 GEN BIBLIOGRAPHY HEALTH EFFECTS OF VINYL CHLORIDE MONOMER: AN AhNOTATED LITERATURE COLLECTION WARREN H,OAK RIDGE NATIONAL LAB)HUFF JE,SAME) ENVIR0M1ENTAL HEALTH PERSPECTIVES,VOL 11 PP.251-252) 1975, JUNE VCM)EFFECTS)HUMAN) 1990 Item 284 ACCESSION NUMBER FILE LOCATION 1242 GEN O % --1 % J o L> J J o o o o u DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order nunfcer 9U001-135640-HIZ -001-007 page 94 set 13 with 374 of 374 items DOCUMENT TYPE TITLE OR SUBJECT ALfTHOR/AF FI LIATION ORIGIN DATE DESCRIPTORS ****** HELD TERMS REVIEW YEAR PUBLICATION ACROPATHY OF THE EXTREMITIES ASSOCIATED WITH VC POLYMERIZATION--A NEW OCCUPATIONAL DISEASE KOVAC A,NONE)KURAJICA L,NONEjJURIC-RUZIC D,NONE)PARAC B,NONE) NONE>VOL 91 NO.5 PP.5-17) 1969 VCM)POLYMERIZATION)ACROOSTEOLYSIS) AC ROPATHY)LIJ.VJES) 1990 Item 265 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ****** HELD TERMS REVIEW YEAR GOVERNMENT CORR BFG'S SUBMISSION OF HISTORICAL DATA AND ANALYTICAL TEST PROCEDURES TO FDA ON RVCM OF PVC RESINS AND COMPOUNDS OSBORNE EB,BFG-CHEMICAL) BFG-CHEMICALT0 FDA) 1975 AUGUST 13 VCM)PVC)FDA)POTABLE WATER)ANALYSIS) RVCM) 1990 Item 266 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ****** REVIEH YEAR 1228 GEN STANDARDS VINYL CHLORIOE AS AN INGREDIENT OF DRUG AND COSMETIC AEROSOL PRODUCTS! FINAL RULE). NONE, NONE) FEDERAL REGISTER>VOL 39 N0.166 PP.30830) 1974, AUGUST 26 VCM)FDA)AEROSOL) 1990 Item 287 ACCESSION NUFBER FILE LXATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** HELD TERMS REVIEH YEAR 1227 GEN GOVERMiENT CORR VINYL CHLORIDE FROM FOOD PACKAGING (CITIZEN PETITION) KAMPELMAN J,NONE)JOHNSON A,NONE)WOLFE SM>NONE) NONE,TO FDA HEARING CLERK) 1975, JULY 1 FDA)VCM)PVC) PUBLIC CITIZEN'S HEALTH RESEARCH GROUP) 1990 Item 286 2Z521094 % DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order nurfcer 911001-135640-WIZ -001-007 page 95 set 13 with 37* of 374 items ACCESSION NUIBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHQR/AFFILIATION ORIGIN DATE DESCRIPTORS xxxxxxx REVIEW YEAR 1226 GEN STANDARDS PRIOR-SANCTIONED POLYVINYL CHLORIDE RESIN (TERMINATION OF NOTICE OF PROPOSED RULEMAKING) NONE,NONE) FEDERAL REGISTERVOL 40 NO.171 PP.40529* 1975, SEPTEMBER 3 PVC)VCM)FDA| 1990 Item 289 ACCESSION NUMJER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS xxxxx: REVIEW YEAR 1225 GEN PAPER VINYL CHLORIDE POLYMERS IN CONTACT HITH FOOD (NOTICE OF PROPOSED RULE MAKING) NONE,NONE) FDA,CFR121 DOCKET N0.75N-0190) 1975 VCM)PVC)FDA) 1990 Item 290 ACCESSION NUTBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** KHIC INDEX NUTBER REVIEW YEAR 1196 GEN JOURNAL ANGIOSARCOMA OF THE LIVER IN VINYL CHLORIDE/ POLYVINYL CHLORIDE WORKERS NONE,NONE) J OF OCCUPATIONAL MEDICINE >VOL 16 NO.12) 1974 ANGIOSARCOMA) LIVER) VCM) PVC) 00377PUBL 1990 Item 291 ACCESSION NUMBER 1187 FILE LOCATION GEN DOCUMENT TYPE PAPER TITLE OR SUBJECT CYTOGENETIC STUDIES OF BONE HARROW CELLS FROM RATS EXPOSED TO VINYL CHLORIDE AUTHOR/AFFILIATION JOHNSTON RV,DOH CHEMICAL CO)MENSIK DJ,SAMEiPIWERTON HN,SAME> NHORTON EB,UNIV OF TEXAS) ORIGIN DOW CHEMICAL CO,FOR MCA DATE 1975 ABSTRACT STUDIES BY THE BIOMEDICAL AND COMPARATIVE TOXICOLOGY RESEARCH LABORATORY OF THE DOM CHEMICAL COMPANY,FREEPORT, TEXAS, SHOW THAT THERE NAS NO SIGNIFICANT INCREASE IN THE CHROMOSOMAL ABERRATION RATES OF BONE MARROW CELLS OF RATS EXPOSED TO VARYING DOSES OF VINYL CHLORIDE FOR ONE YEAR AT INDUSTRIAL BIO-TEST LABORATORIES, DECATUR, ILLINOIS. DESCRIPTORS xxxxxxx MUTAGENICITY) VINYL CHLORIDE MONOMER) BONE MARROW) CHROMOSOMAL ABERRATION)INHALATION)RATS) HELD TERMS CYTOGENETIC EFFECTS) CHROMOSOMAL ABNORMALITIES K* fC'si^.y fi# JL. v * *3 % o DATA SEARCH ON VCH/T0XIC2TY STUDIES FOR CRAIG ELGUT Order nutter 911001-135640-WIZ -001-007 page 96 set 13 with 379- of 374 items KWIC INDEX NUMBER REVIEW YEAR 00367PAPE 1990 Item 292 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ** KHIC INDEX NUMBER REVIEW YEAR 1182 GEN JOURNAL CARCINOGENICITY BIOASSAYS OF VINYL CHLORIDE:1.RESEARCH PLAN AND EARLY RESULTS LEFEMINE G*N0NE) HALTONI C,NONE> ENVIRONMENTAL RESEARCH*VOL 7 PP.387-405) 1974 THESE INVESTIGATIONS ARE CONCERNED WITH DETERMINING THE ONCOGENIC POTENTIALITIES OF VINYL CHLORIDE (VC) IN EXPERIMENTAL ANIMALS. THE EFFECT OF THIS COMPOUND IS BEING STUDIED IN RELATION TO VARIOUS EXPERIMENTAL FACTORS* SUCH AS ROUTE OF ADMINISTRATION* DOSE LEVEL*LENGTH OF TREATMENT SPECIES* STRAIN* AND AGE OF THE ANIMALS. PRELIMINARY RESULTS ARE PRESENTED. WHEN GIVEN BY INHALATION* VC INDUCES IN RATS, ZYIBAL GLAND CARCINOMAS, NEPHROBLASTOMAS* AND ANGIOSARCOMAS OF THE LIVER AND OF OTHER ANATOMICAL SITES) AND IN MICE, PULMONARY ADENOMAS* MAM1ARY CARCINOMAS AND LIVER ANGIOSARCOMAS. A DIRECT RELATIONSHIP HAS BEEN FOUND BETWEEN DOSE AND LENGTH OF TREATMENT AND NEOPLASTIC RESPONSE. VINYL CHLORIDE! CARCINOGENICITY) INHALATION) MICE) RATS) 00362PUBL 1990 Item 293 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS **** HELO TERMS KWIC INDEX NUtBER REVIEW YEAR 1181 GEN JOURNAL VINYL CHLORIDE INDUCED LIVER DISEASE THOMAS LBNCI)POPPER H,NONE)BERK PD*NONE)SELIKOFF I,N0NE) FALK H*NONE) NONE,VOL 292 NO.l) 1975, HISTOLOGIC EXAMINATION OF LIVER TISSUE (EIGHT AUTOPSY AND 18 BIOPSY SPECIMENS) AND FIVE SPLEENS FROM 20 WORKERS WITH VINYL CHLORIDE POLYMERIZATION SHOWED HEPATIC ANGIOSARCOMAS IN 15. IN ADDITION, A PECULIAR PATTERN OF PROGRESSIVE PORTAL-TRACT,INCONSPICUOUS INTRALOBULAR AM) CONSPICUOUS CAPSULAR FIBROSIS HAS OBSERVED IN THE FIVE WORKERS WITHOUT ANGIOSARCOMA, IN ALL THE SEVEN PATIENTS WITH ANGIOSARCOMA FROM WHOM TUMOR-FREE PORTIONS OF THE LIVER HERE AVAILABLE* 1 AND IN TWO TUMOR-FREE BIOPSIES FROM PATIENTS SUBSEQUENTLY FOUNO TO HAVE ANGIOSARCOMA. THE FIBROSIS NAS ACCOMPANIED BY SPLENOMEGALY. HYPERTROPHY AND HYPERPLASIA OF BOTH HEPATOCYTES AND HEPATIC AND SPLENIC MESENCHYMAL CELLS WERE ALSO SEEN. THE HISTOLOGIC SIMILARITY TO CHRONIC INORGANIC ARSENICAL POISONING* IN NHICH ANGIOSARCOMAS ALSO OCCUR, AND TO IDIO- PATHIC PORTAL HYPERTENSION (BANTI'S SYNDROME) SUGGESTS THAT THE LATTER SYNDROME AT TIMES RESULTS FROM UM*W TOXIC, POSSIBLY ENVIROMiENTAL, CHEMICALS. ANGIOSARCOMA) VCM) HUMAN) EFFECTS) CHRONIC) ARSENIC) HEPATOTOXICITY) SPLENOMEGALY) NEH ENGLAND J OF MEDICINE) 00361PUBL 1991 (]Q/ % O DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order nunfcer 911001-135640-HIZ -001-007 page 97 sal 13 with 374 of 374 items ,? G 5 2 9 l4 Item 294 ACCESSION NUMBER FILE LOCATION GEN DOCUMENT TYPE TOXICITY STUDY TITLE OR SUBJECT EXPERIMENTS ON THE CHRONIC TOXICITY OF A COPOLYMER OF VINYL AND VINYLXDINE CHLORIDE AUTHOR/AFFILIATION SEELER AO,HARVARD UNIVjCLINTON H,SAME)BOGGS J>SAME) DRIVER P,SAME I ORIGIN HARVARD UNXV ' DATE 1947 ABSTRACT RATS FED A DIET CONTAINING SX VINYL AND VINYLIDINE CHLORIDE COPOLYMER FOR THO YEARS SHOWED NO TOXIC EFFECTS. TWO DOGS HERE FED A DIET CONTAINING SX VINYL AND VINYLIDINE CHLORIDE COPOLYMER FOR TWO YEARS WITHOUT EVIDENCE OF TOXIC EFFECTS. DESCRIPTORS xxxx*** PVC) VCM) CHRONIC) CARCINOGENICITY* RATS) DOGS) ORAL) HELD TERMS DIET{VINYLIDINE CHLORIDE) KHIC INDEX NUM3ER -40353T0XS- REVIEM YEAR 1995 Item 295 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** HELD TERMS KHIC INDEX NUMBER REVIEW YEAR 1138 GEN JOURNAL INDUSTRY'S LATEST CANCER SCARE NONE,NONE) NONE 1974, FEBRUARY LIVER) ANGIOSARCOMA) PVC) VINYL CHLORIDE) VINYLIOENE CHLORIDE) BUSINESS NEEK) 00315PUBL 1990 Item 296 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ******* HELD TERMS KHIC INDEX NUtBER REVIEW YEAR 1137 GEN JOURNAL PROPERTIES AND ESSENTIAL INFORMATION FOR SAFE HANDLING AND USE OF VINYL CHLORIDE NONE,NONE) NONE 1972 VINYL CHLORIDE) TOXICITY DATA) LIVER) MCA) 00314PUBL 1990 Item 297 ACCESSION NUrER FILE LOCATION GEN DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order number 911001-135640-WIZ -001-007 page 98 set 13 with 374 of 374 itens DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS hhhh HELD TERMS KHIC INDEX NUTOER REVIEW YEAR TOXICITY STUDY A STUDY OF THE TOXICITY OF GEON 202 RESIN SEELER AO,HARVARD UNIV)CLINTON M,SAME)BOGGS J,SAME DRINKER P,SAME) HARVARD UNIV,FOR BFG) 1947 DIETARY ADMINISTRATION OF GEON 202 RESIN AT EX FOR TWO YEARS DID NOT PRODUCE ANY COMPOUND RELATED EFFECTS IN RATS OR DOGS. VCM)VDC>PVC)EFFECTS)DIET)RATS)DOGS)CHRONIC) GEON 202) 00298TOXS 1992 Item 298 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS **** HELD TERMS KMIC INDEX NUTOER REVIEW YEAR 931 GEN JOURNAL ONCOGENIC RESPONSE OF RAT SKIN LUNGS AND BONES TO VINYL CHLORIDE CAPUTO ANONEJBIGOTTI A,SAME)VIOLA PL,SAME) CANCER RESEARCH,VOL 31 PP.516-522) 1971, MAY RATS (AR/IRE NISTAR STRAIN) EXPOSED FOR 12 MONTHS TO VAPORS OF VCM(30,000PPM) DEVELOPED TUMORS OF THE SKIN,LUNGS AW BONES. THE CUTANEOUS TUMORS, WHICH ALWAYS APPEARED IN THE AREA IN WHICH SUBMAXILLARY AND PAROTID GLANDS ARE LOCATED, HAVE BEEN HISTOLOGICALLY RECOGNIZED AS EPIDERMOID CARCINOMAS , PAPILLOMAS, AND MUCOEPIDERMOID CARCINOMAS. THE MORPHOLOGICAL CHARACTERISTICS OF LUNG TUMORS, WHICH OCCURED IN A LOWER PERCENTAGE, HERE MAINLY OF THE ADENOCARCINOMA TYPE, WITH THE EXCEPTION OF A SINGLE EPIDERMOID TUIOR ORIGINATING FROM THE EPITHEHAL COVERING CELLS. IN A MINOR NUMBER OF RATS, A LARGE PROLIFERATION OF CARTILAGINOUS TISSUE DIAGNOSED AS OSTEOCHONDROMA DEVELOPED IN THE METACARPAL AND METATARSAL REGIONS OF THE FOUR LIMBS. VCM) INHALATION) RATS) CARCINOGENICITY) EFFECTS) CHRONIC) REGINA ELENA INSTITUTE FOR CANCER (ITALY)) 00047PUBL 1990 Item 299 ACCESSION NUTOER 889 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT THE CORRELATION OF CLINICAL AND ENYIRCWENTAL MEASUREMENTS FOR WORKERS EXPOSED TO VINYL CHLORIDE AUTHOR/AFFILIATION KRAMER CG,DOH CHEMICAL CO)HUTCHLER JE,SAME) ORIGIN AIHA,V0L 33 NO.l PP.19-30) DATE 1972, JANUARY ABSTRACT A METHOD IS DESCRIBED FOR THE STATISTICAL CONSOLIDATION AND CORRELATION OF ENVIRONMENTAL MEASUREMENTS AND CLINICAL FINDINGS USING AS AN EXAMPLE A GROUP OF HEALTHY HALE WORKERS EXPOSED ROUTINELY TO VINYL CHLORIDE FOR PERIODS UP TO 25 YEARS. RETROSPECTIVE IN NATURE THE STUDY REVEALS SEVERAL STATISICALLY SIGNIFICANT EFFECTS FROM CHRONIC EXPOSURES TO VINYL CHLORIDE AND TRACES OF VXNYLIDENE CHLORIDE. DESCRIPTORS xxxxxxx VINYL CHLORIDE)NORKERS)EXPOSURE) VINYLIDENE CHLORIDE)CHR0NIC) EFFECTS) REVIEW YEAR 1990 </'vO /V 1033 yP % O DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order nuriwr 9U001-135640-WIZ -001-007 page 99 set 13 with 374 of 374 items Item 300 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** HELD TERMS KWIC INDEX NUMBER REVIEW YEAR 888 GEN PUBLICATION LIFESPAN ORAL TOXICITY STUDY OF VINYL CHLORIDE IN RATS FERON VJ,NONE)HENDRIKSEN CFM,NONE)SPEEK AJNCNE)TIL HP,NONE) SPIT BJ,N0NE> NONE,VOL 19 PP.317-333) 1981, JUNE THE PRESENT STUDY SHOWED THAT ORALLY ADMINISTERED VCM IS A CARCINOGEN IN RATS, AND THAT THE "NO-OBSERVED-AOVERSE-EFFECT LEVEL" IN RATS HAS LONER THAN 1.7 MG/KG BODY HEIGHT/DAY UNDER THE RIGOROUS CONDITIONS OF CONTINUOUS ORAL VCM EXPOSURE RESULTING FROM THE RELEASE OF VCM FROM PVC PONDER PRESENT IN THE 6ASTR0- INTESTINAL TRACT. ORAL)PVC >VCM)RATSjCARCINOGEN)0IET) FOOD AND COSMETICS TOXICOLOGY) 04335 1990 Item 301 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATIDN ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 887 GEN REPORT LIFESPAN ORAL CARCINOGENICITY STUDY OF VINYL CHLORIDE IN RATS (FINAL REPORT) TIL HP,NONE)Ift1EL HR,NONE)FERON VJ,NONE) NONE,REPORT NO.V83.285/291099 1983, SEPTEfBER IT HAS CONCLUDED THAT UNDER THE CONDITIONS OF THE PRESENT EXPERIMENT: VCM AT A LEVEL OF 1.3 MG/KG BODY HEIGHT/DAY INDUCES NEOPLASTIC AND NON-NEOPLASTIC CHANGES IN THE LIVER OF RATS) VCM AT A LEVEL OF 0.13 MG/KG BODY WEIGHT/DAY MAY LEAD TO MORE FEMALE RATS BEARING FOCI OF CELLULAR ALTERATION IN THE LIVER) VCM AT LEVELS OF 0.014 OR 0.13 MG/KG BODY HEIGHT/DAY MAY RESULT IN AN INCREASED INCIDENCE OF BASOPHILIC FOCI OF CELLULAR ALTERATION IN THE LIVER OF FEMALE RATS)0.13MG VCM/KG BODY HEIGHT/ DAY IS A "NO-OBSERVED-ADVERSE-EFFECT-LEVEL" WITH RESPECT TO THE INDUCTION OF TUMOURS IN RATS. PVC)VCM>ORAL)FEEDING STUDY)RATS)CANCER)CHRONIC)EFFECTS)DIET) DIETARY ADMINISTRATION)CIVO INSTITUTES TNO) 1990 Item 302 ACCESSION NUTOER 725 FILE LOCATION GEN DOCUMENT TYPE PAPER TITLE OR SUBJECT WORKING CONDITIONS AND MEASURES FOR THEIR SANITATION IN THE PRODUCTION AND UTILIZATION OF VINYL CHLORIDE PLASTICS AUTHOR/AFFILIATION ORIGIN TRIBUKH SL,NONE iTIKHOMIROVA NP,NONE>LEVIN SV,NQNE>KOZLOV LA,NONE) NONE,VOL 10 PP.38-45) DATE 1949 DESCRIPTORS *xxxx VCM)TOXICITY)PVC)PCB'S) .'Am/ ?*t~' sC> % o \y DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAI6 ELGUT Order number 911001-135640-NIZ -001-007 page 100 set 13 with 374 of 374 items HELD TERMS REVIEW YEAR HEPATITIS)ARG SANIT) 1990 Item 303 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** REVIEH YEAR 723 GEN JOURNAL THE EFFECT OF REPEATED VINYL CHLORIDE EXPOSURE ON RAT HEPATIC METABOLIZING ENZYMES DU JTNONE)TSENG HTN0NEiTAKtURRO CH,UNIV OF LOUISVILLE) TOX AND APPLIED>VOL 42 PP.1-10) 1982 VCM)METABOLISM 1990 Item 304 ACCESSION NUttER 721 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT TEN CANADIAN CASES OF ANGIOSARCOMA OF THE LIVER IN VINYL CHLORIDE WORKERS AUTHOR/AFFILIATION DELORME F>N0NE) ORIGIN NONE>VOL 23 NO.2PP.97-103) DATE 1978 ABSTRACT TEN CASES OF ANGIOSARCOMA OF THE LIVER AMONG VINYL CHLORIDE WORKERS FROM A PLANT IN SKAHINXGAN, QUEBEC, ARE REPORTED. THE AUTHOR INSIST MOSTLY ON THE OCCUPATIONAL HISTORY OF THESE WORKERS AND ON THE MORPHOLOGIC DESCRIPTION OF THE LESIONS. A PATHOGENIC HYPOTHESIS IS SUBMITTED. DESCRIPTORS ******* VCM)ANGIOSARCOMA)HUMAN)EFFECTS)LIVER HELD TERMS AMALES O'ANATOMIE PATHOLOGIQUE) REVIEH YEAR 1990 Item 305 ACCESSION NUt-BER 712 FILE LOCATION GEN DOCUMENT TYPE PAPER TITLE OR SUBJECT AUTHOR/AFFILIATION VINYL CHLORIDE CONTENT OF SUBCUTANEOUS ADIPOSE TISSUE FROM VINYL CHLORIDE POLYMERIZATION WORKERS KNITTLE JL>NEN YORK IMIV)FONTANARES P,SAME)DAUM S,SAME) SELIKOFF IJ,SAME) ORIGIN NONE,NONE) DATE 1974 ABSTRACT SIGNIFICANT LEVELS OF VINYL CHLORIDE MONOMER HERE FOUND IN SUBCUTANEOUS FAT DEPOTS OF WORKERS EXPOSED TO THE GAS DURING THE MANUFACTURE OF POLYVINYL CHLORIDE. THE COMPOUND NAS NOT DETECTED IN A CONTROL GROUP OF UNEXPOSED WORKERS. DESCRIPTORS xxxxxxx VCM)ADIPOSE)HUMANS)EFFECTS HELD TERMS BIOACCUMULATOR)DEPOSITION)CONCENTRATION) REVIEW YEAR 1990 Item 306 ACCESSION NUMBER 711 2252II00 vO O i DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order nunfeer 911001-135640-WIZ -001-007 page 101 set 13 with 374 of 374 items FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR GEN PUBLICATION HEMANGIOSARCOMA AND HEPATOCELLULAR CARCINOMA OF THE LIVER FOLLOWING VINYL CHLORIDE EXPOSURE GOKEL JMyNONEiLIEBEZEIT E,NONE)EDER M,NONE) NONE,VOL 372 NO.3 PP.195-203) 1976 A REPORT IS GIVEN OF THE CLINICAL AWJ AUTOPSY FINDINGS OF TWO MEN WHO DIED FROM MALIGNANT LIVER NEOPLASM FOLLOWING OCCUPATIONAL EXPOSURE TO VINYL CHLORIDE. THE FIRST PATIENT NAS A 44-YEAR-OLD MAN WITH AN HEMANGIOSARCOMA OF THE LIVER, THE SECOND PATIENT A 67-YEAR-OLD MAN WITH AN HEPATOCELLULAR CARCINOMA. SO FAR AN HEPATOCELLULAR CARCINOMA DUE TO VINYL CHLORIDE HAS NOT YET BEEN OBSERVED IN MAN. ITS OCCURRENCE, HOWEVER, HAS BEEN SUGGESTED FROM THE RESULTS OF ANIMAL EXPERIMENTS. THE CONNECTION OF HEPATOCELLULAR CARCINOMA NITH EXPOSURE TO VINYL CHLORIDE IS DISCUSSED. VCM)ANGIOSARCOMA)LIVER)CANCER)HUHANS (EFFECTS) HEPATOCELLULAR CARCINOMA)VIRCHON ARCH PATH ANAT) 1990 Item 307 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS xxxxx: REVIEW YEAR 710 GEN BIBLIOGRAPHY WORLD REGISTER OF CASES OF ANGIOSARCOMA OF THE LIVER!ASL) DUE TO VCM bermett b,ici) ICI 1991, FEBRUARY THIS DOCUMENT IS A REVIEW OF ALL ANGIOSARCOMA DEATHS IN PEOPLE WHO HAVE BEEN EMPLOYED IN A VCM/PVC FACILITY. IT IS UPDATED APPROXIMATELY BI-ANNUALLY. VCM)ANGIOSARCOMA) HUMANS)E FFECTS 1992 Item 308 ACCESSION NUM5ER 706 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT ASSOCIATION OF AN ANGIOSARCOMA OF THE LIVER WITH A HEPATOMA IN A VINYL CHLORIDE WORKER AUTHOR/AFFILIATION DELORME F,N0NE) ORIGIN NONE,VOL 23 NO.2 PP.105-114) OATE 1978 ABSTRACT THIS REPORT DEALS WITH A 51 YEARS-OLD HAN WHO, FOR 23 YEARS AND 4 MONTHS OF HIS WORKING LIFE, HAD BEEN EXPOSED TO VINYL CHLORIOE VAPORS. AUTOPSY REVEALED A HEPATOMA ASSOCIATED WITH AN ANGIOSARCOMA OF THE LIVER. THE CASE IS THE FIRST EVER TO BE REPORTED IN THE MEDICAL LITERATURE. THIS CASE RAISES DOUBT ABOUT THE THEORY WHICH SUGGESTS THAT THE CARCINOGENIC EFFECT OF VINYL CHLORIDE IN MAN ELICIT A TUMOR OF VASCULAR NATURE. DESCRIPTORS xxxxxxx VCM)ANGIOSARCOMA)HUMANS>EFFECTS)LIVER HELD TERMS ANALES D'ANATOMIE PATHOLOGIQUEi REVIEW YEAR 1990 *Jt`rn VTO'-f y* c> o i DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order nutfcer 911001-135640-HIZ -001-007 page 102 set 13 with 374 of 374 items Item 309 ACCESSION HUNGER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS xxxxx: HELD TERMS REVIEH YEAR 704 GEN PUBLICATION SCLERODERMA LIKE SKIN CHANGES*RAYNAUD'S SYNDROME AND ACROOSTEOLYSES IN HORKERS IN THE POLYVINYL CHLORIDE PRODUCING INDUSTRY JUHE S>NONE)LANGE CE,NONE) NONE,VOL 97 PP.1922-1923) 1972 VCM)AOL) SYND ROME SCLEROQERMA)DTSCH MED NSCHR) 1990 Item 310 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS xxxxxxx HELD TERMS REVIEH YEAR 703 GEN PUBLICATION TOXIC TRIGEMINAL DISEASE AND POLYVINYLIDENE CHLORIDE KRIEGER J,NONE)WARTER JM,N0NEjMENGUS M,NONE)MEHL J,NONE)ISCH FN0NE> NONE,VOL 43 PP.64-68) 1971 VCM)AOL)HUMANS)EFFECTS REVUE D`OTO-NEURO-OPHTALMOLOGIE) 1990 Item 311 ACCESSION NUT6ER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN OATE DESCRIPTORS xxxxx: HELD TERMS REVIEH YEAR 702 GEN PAPER OCCUPATIONAL ACROOSTEOLYSIS (AOL): AN EPIDEMIOLOGIC INVESTIGATION OF A NEW DISEASE AMONG POLYVINYL CHLORIDE SYNTHESIS HORKERS MAGNUSON J,NONE)DIt*tAN BD,NONE)COOK HA,NONE)GIEVER PM>NONE)NKITEHOUSE NM*N0NE) NONE,PP.621-622) 1969, SEPTEMBER 22-27 VCh)AOL)HUMANS)EFFECTS)EPIDEMIOLOGY INTERNATIONAL CONGRESS ON OCCUPATIONAL HEALTH) 1990 Item 312 ACCESSION NUtBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN 701 GEN PUBLICATION OCCUPATIONALACROOSTEOLYSIS MARKOWITZ SSN0NE)MC DONALD CJSAME)FETHIERE H,SAME)KERZNER MS,SAME) ARCH DERMATOL>VOL 106 PP.219-223) 22521.10 A>* O' r~ O' \T> o DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order nwnber 911001-135640-HIZ -001-007 page 103 set 13 with 374 of 374 items DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 1972, AUGUST OCCUPATIONAL ACROOSTEOLYSIS IS AN UNUSUAL DISEASE IN WHICH AFFECTED PERSONS HAVE SCLERODERMOID-LIKE LESIONS OF THE SKIN, CONDITIONS SIMILAR TO RAYNAUD'S PHENOMENON, AND ASYMPTOMATIC, BONY DEFECTS OF THE EXTREMITIES. TO OUR KNOWLEDGE, THE DISEASE IS CONFINED SOLELY TO WORKERS IN THE PLASTICS INDUSTRY, SPECIFICALLY THOSE ENGAGED IN THE PRODUCTION OF POLYVINYL CHLORIDE FROM VINYL CHLORIDE. THE INCIDENCE OF THE DISEASE IS UtKNOWN BUT IS THOUGHT TO OCCUR IN V/. OR LESS OF WORKERS. xxxxxxx VCMiACROOSTEOLYSIS{SYNDROME{HUMANS)EFFECTS BROW UNIV)RAYNAUD'S SYNDROME) 1990 Item 313 ACCESSION NUTOER 697 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT OCCUPATIONAL LESIONS OF THE SKIN DUE TO PVC AUTHOR/AFFILIATION SONNECK HJ,NONE> ORIGIN NONE,VOL 8 PP.38-43) DATE 1962 ABSTRACT TWO CASES OF OCCUPATIONAL LESIONS OF THE SKIN OBSERVED IN THE INDUSTRY MAKING USE OF POLYVINYL CHLORIDES, ARE DEALT HITH. IN THE LIGHT OF TEST RESULTS IT IS SUPPOSED THAT A COMPLEXE TOXIC AND r' > ALLERGIC MECHANISM PLAYS A PART, THAT MEANS THAT THE EMULSIFIER HITH ITS STRONG DEGREASING PROPERTIES OR THE SOLVENTS USED MAY CAUSE NOT ONLY AN IRRITATION OF THE SKIN BUT HAY EVEN FURTHER A SENSIBILIZATION TO POLYVINYL CHLORIDE WHICH, GENERALLY, IS NOT CONSIDERED TO BE A SENSITIZER. DESCRIPTORS VCM {SKIN) LESIONS {HORKERS {HUMAN) EFFECTS)SOLVENTS HELD TERMS BERUFSDERMATOSEN) REVIEW YEAR 1990 Item 314 & ACCESSION NUMBER 694 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT OCCUPATIONAL ACROOSTEOLYSIS AUTHOR/AFFILIATION WILSON RH,BFG)MC CORMICK WE,SAME{TATUM CF,NONE{CREECH JL,NONE{ ORIGIN JAMA,VOL 201 NO.8 PP.577-581) DATE 1967, AUGUST 21 ABSTRACT IN 31 CASES OF ACROOSTEOLYSIS OF THE HANDS OF WORKMEN ASSOCIATED WITH VINYL CHLORIDE (CH2CHCL) POLYMERIZATION PROCESSES, THE OSTEOLYSIS WAS SPECIFIC TO THE DISTAL PHALANGES OF HANDS AND WAS FREQUENTLY ASSOCIATED WITH RAYNAUD'S SYMPTOMS. AFFECTED PERSOWEL RANGED IN AGE FROM 26 TO 47. THE DISORDER IS BELIEVED TO HAVE RESULTED FROM A COMBINATION OF PHYSICAL INSULT, CHEMICAL INSULT, AND PERSONAL IDIOSYNCRASY. THE SPECIFIC CAUSES ARE UNKNOW. THE PREVALENCE HAS FOUND TO BE LESS THAN 3Y. AMONG EMPLOYEES PERFORMING SIMILAR NORK. NO CASES HERE FOUND IN WORKMEN USING OR PROCESSING THE POLYIER OR MANUFACTURING COMMERCIAL RESINS. DESCRIPTORS REVIEW YEAR VCM)AOL{HUMAN{EFFECTSjNORKERS)EPIDEMIOLOGY 1990 Item 315 c c BFG52980 521103 ) .) DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order number 911001-135640-HIZ >001-007 page 104 set 13 with 574 of 374 items ; ACCESSION NUMBER 688 FILE LOCATION GEN DOCUMENT TYPE PROCEEDINGS TITLE OR SUBJECT OCCUPATIONAL CARCINOGENESIS AUTHOR/AFFILIATION MALTONI CN0NE) ORIGIN NONE*VOL 2 SERIES N0.322) DATE ABSTRACT 1973, APRIL 9-12 OVERVIEW OF CHEMICAL CARCINOGENESIS AND ANIMAL STUDIES SHOWING VCM INDUCED CANCER OF THE LIVER (ANGIOSARCOMA) AND ZYMBAL GLAND. DESCRIPTORS xxxxxxx VCM)RATS)ANGIOSARCOMA)ZYMBAL GLAM) )TUMORS)CARCINOGENICITY) INHALATION) CHRONIC)EFFECTS HELD TERMS INTERNATIONAL CONGRESS ON OCCUPATIONAL HEALTH) REVIEW YEAR 1990 Item 516 ACCESSION NUMBER 686 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT ACUTE INHALATION TOXICITY OF VINYL CHLORIDE TO LABORATORY ANIMALS AUTHOR/AFFILIATION MASTROMATTEO E,NONE)FISHER AM,NONE)CHRISTIE H,NQNE)DANZI6ER H,N0NE) ORIGIN J OF AIHA,VOL 21 PP.394-398) DATE 1960 ABSTRACT IRRITATION AND SYMPTOMS RELATING TO NARCOSIS AND DEATH NERE OBSERVED OVER CONCENTRATIONS OF 10-40* IN MICE,RATS AND GUINEA PIGS. DESCRIPTORS xxxxxxx VCM)INHALATCON)MICE)RATSjGUINEA PIGS)NARCGSIS REVIEW YEAR 1990 Item 517 ACCESSION NUMBER 685 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT CHRONIC ORAL TOXICITY TO RATS OF A VINYL CHLORIDE-VINYL ACETATE COPOLYMER AUTHOR/AFFILIATION SMYTH HFNONE)WEIL CSSAME) ORIGIN TOX AND APPLIED,VOL 9 PP.501-B04) DATE 1966 ABSTRACT STARTING IN 1944* ALBINO RATS OF BOTH SEXES CAGED TOGETHER HERE MAINTAINED FOR TWO YEARS UPON DIETS CONTAINING 1.5* AND 12* OF A VINYL CHLORIDE-VINYL ACETATE COPOLYMER. NO EFFECTS ATTRIBUTABLE TO THE RESIN MAS FOUND. DESCRIPTORS xxxxoh* PVC)VCM)VDC)CARCINOGENICITYORAL)RATS)CHRONIC)EFFECTS HELD TERMS DIET) MELLON INSTITUTE) REVIEW YEAR 1990 Item 518 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT 664 GEN PUBLICATION ONE-YEAR TIME SEQUENCE INHALATION TOXICITY STUDY OF VINYL CHLORIDE IN RATS: I. GROWTH MORTALITY* HAEMATOLOGY, CLINICAL CHEMISTRY AND ORGAN HEIGHTS 22521104 >%> q tf-* sj 3 J .J 3 DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELSUT Order nun&er 911001-135640--NIZ -001--007 page 105 set 15 with 574 of 574 items AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR FERON VJNONE)KRUYSSE A,NONEiTTL HP,N0NE> NONE>VOL 15 PP.25-28) 1979 HISTAR RATS WERE EXPOSED TO ATMOSPHERES CONTAINING 0 I CONTROL) OR 5000 PPM VINYL CHLORIDE MONOMER (VCM), 7 HR/DAY, 5 DAYS/HEEK, FOR A PERIOD OF 52 WEEKS. AFTER 4,15,26 AND 52 WEEKS EACH TIME 10 RATS/SEX/GROUP HERE KILLED AND SUBJECTED TO EXTENSIVE EXAMINATIONS. THE PRESENT PAPER DEALS WITH GROWTH, MORTALITY, HAEMATOLOGY, CLINICAL CHEMISTRY AND ORGAN HEIGHTS. THE PRESENT STUDY DID NOT PRODUCE OBVIOUSLY SUITABLE PARAMETERS FOR EARLY DIAGNOSING "VCM-DISEASE" IN MAN. VCM\RATS)INHALATIONjCHRONIC>DETERMINATION DIAGNOSIS) TOXICOLOGY) 1990 Item 519 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** HELD TERMS REVIEW YEAR 683 GEN PUBLICATION ANESTHESIA XXVII: NARCOSIS WITH VINYL CHLORIDE OSTER RHNONE)CARR CJNONE)KRANTZ JC,NONE) NONE,VOL 8 PP.359-361) 1947, JULY NARCOSIS AND CARDIAC ARRHYTHMIA OBSERVED IN DOGS EXPOSED TO 7 TO SOX VCM. VCM)CARDIAC ARRHYTHMIA)NARCOSIS)INHALATION)ACUTE)DOGS ANESTHESIA) 1990 Item 320 ACCESSION NUCBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEH YEAR 682 GEN PUBLICATION ONE-YEAR TIME-SEQUENCE INHALATION TOXICITY STUDY OF VINYL CHLORIDE IN RATS * II. MORPHOLOGICAL CHANGES IN THE RESPIRATORY TRACT,CERUMINOUS GLANDS, BRAIN,KIDNEYS,HEART AND SPLEEN. FERON VJ,NONE)KROES RNONE) NONE,VOL 13 PP.131-141) 1979 HISTAR RATS HERE EXPOSED TO ATMOSPHERES CONTAINING 0 (CONTROL) OR BOO0 PPM VINYL CHLORIDE MONOMER (VCM), 7 HR/DAY, 5 DAYS/HEEK, FOR A PERIOD OF 52 MEEKS. AFTER 4,13,26 AND 52 MEEKS EACH TIME 10 RATS/ SEX /GROUP HERE KILLED AND SUBJECTED TO EXTENSIVE EXAMINATIONS. THE PRESENT PAPER DESCRIBES THE MORPHOLOGICAL CHANGES OBSERVED IN THE RESPIRATORY TRACT, CERUMINOUS GLANDS,BRAIN, KIDNEYS,HEART AND SPLEEN. THE VCM-EFFECTS INCLUDED INCREASED DEGREE OF TUBULAR NEPHROSIS, MILD FOCAL DEGENERATION OF THE MYOCARD, AND INCREASED HAEMATOPOIETIC ACTIVITY IN THE SPLEEN. IN ADDITION, PRIMARY TUMOURS HERE FOUND ZN THE BRAIN (EPENDYMOMA),LUNGS (PAPILLARY ADENOMA AND MESENCHYMAL TYPE OF TUMOUR), CERUMINOUS GLANDS (MAINLY KERATINIZED SQUAMOUS CELL CARCINOMAS), AND NASAL CAVITY (CARCINOMAS OF THE OLFACTORY EPITHELIUM, CARCINO-SARCOMA,E$THESIONEUROEPITHELIOMA). VCM)INHALATION)RATS)CHRONICICARCINOGENICITY )RESPIRATORY EFFECTS RESPIRATORY TRACT) TOXICOLOGY) 1990 22521105 00 o\ vD o DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order nvnber 911001-135640-WIZ -001-007 page 106 set 13 with 374 of 374 items Item 321 ACCESSION NUMBER 661 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT ONE-YEAR TIME-SEQUENCE INHALATION TOXICITY STUDY OF VINYL CHLORIDE IN RATS: III. MORPHOLOGICAL CHANGES IN THE LIVER AUTHOR/AFFILIATION FERON VJ>NONE(SPIT BJ>N0NE>I(f1EL HRN0NE)KR0ES R,N0NE( ORIGIN NONE,VOL 13 PP.143-154( DATE 1979 ABSTRACT NISTAR RATS HERE EXPOSED TO ATMOSPHERES CONTAINING 0 (CONTROL) OR 5000 PPM VINYL CHLORIDE MONOMER (VCM), 7 HR/DAY, S DAYS/WEEK., FOR A PERIOD OF 52 KEEKS. AFTER 4>1326>52 KEEKS EACH TIKE 10 RATS/SEX/ GROUP HERE KILLED AND SUBJECTED TO EXTENSIVE EXAMINATIONS. THE PRESENT PAPER DESCRIBES THE MORPHOLOGICAL CHANGES FOUND IN THE LIVER. THE MAJOR PARENCHYMAL CHANGES COMPRISED SWELLING AND MALFORMATION OF MITOCHONDRIA, AN INCREASED AMOUNT OF SMOOTH ENDOPLASMIC RETICULUM, NECROSIS,NUCLEAR AND CELLULAR POLYMORPHISM OF HEPATOCYTES, "FOCI OF CELLULAR ALTERATION", NEOPLASTIC NODULES AND HEPATOCELLULAR CARCINOMAS. A REDUCED GLUCOSE -6-PHOSPHATASE ACTIVITY IN HEPATOCYTES AND A STRON SINUSOIDAL ACTIVITY OF ALKALINE PHOSPHATASE WERE FOUND HITHIN "FOCI OF CELLULAR ALTERATION". THE NON-PARENCHYKAL ALTERATIONS INCLUDED FOCAL DILATATION OF SINUSOIDS, FOCAL PROLIFERATION OF ATYPICAL SINUSOIDAL CELLS AND MULTICENTRIC ANGIOSARCOMAS. THE EFFECTS OF VCM ON THE HEPATIC PARENCHYMA SEEMED TO PRECEDE THOSE ON THE HEPATIC STROMA. DESCRIPTORS xxxxxxx VCM (INHALATION(RATS(CHRONIC(CARCINOGENICITY > LIVER HELD TERMS TOXICOLOGY REVIEW YEAR 1990 Item 322 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS **-*<* REVIEW YEAR 680 GEN JOURNAL EFFECTS OF SINGLE AND REPEATED EXPOSURES OF HUMANS AND RATS TO VINYL CHLORIDE LESTER D,N0NE)GREEf6ERG LA,NONE(ADAMS HR>NONE( J OF AIHA,VOL 24 PP.265-275( 1963, MAY-JUNE RATS EXPOSED EIGHT HOURS DAILY TO VINYL CHLORIDE AT CONCENTRATIONS OF 2 VCH(RATS(HUMANS(INHALATION(SUBCHRONIC 1990 Item 323 ACCESSION NUtCER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 679 GEN PUBLICATION NONNEOPLASTIC EFFECTS OF VINYL CHLORIDE IN MOUSE LUNG SUZUKI Y,NEH YORK UNIV( ENVIRONMENTAL RESEARCH,VOL 21 PP.235-253( 1980 IN A PREVIOUS STUDY, A HIGH INCIDENCE OF PULMONARY TUMORS (ALVEOLOGENIC NEOPLASIA IN MOUSE LUNG EXPOSED TO VINYL CHLORIDE AT HEAVY DOSE (2500 AND 6000 PPM) FOR LONG DURATIONS (5 AND 6 MONTHS) 22521106 % O DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order rxwber 9110Q1-135640-HIZ -001-007 page 107 set 13 with 374 of 374 items 23521107 DESCRIPTORS HELD TERMS REVIEW YEAR WAS REPORTED (Y. SUZUKI, 1978,ENVIR0N.RES. 16,205-301). IN THE PRESENT STUDY, NONNEOPLASTIC EFFECTS IN MOUSE LUNG HERE INVESTIGATED BY LIGHT AND ELECTRON MICROSCOPY. VCM)INHALATION{MICEiLUNG{CARCINOGENICITY{CHRONIC{E FFECTS CITY UNIV OF NEW YORK{ 1990 g W 9&4 Item 324 ACCESSION NUTOER 678 FILE LOCATION GEN DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION PUBLICATION INHALATION PHARMACOKINETICS BASED ON GAS UPTAKE STUDIES BOLT HM,NONE{FILSER JG,NONE)BUCHTER A,NONE) ORIGIN NONE,VOL 48 PP.213-228) DATE 1981 ABSTRACT AFTER COMPARING A 2-HR EXPOSURE TO 5 PPM VCM WITH TWO 50 PPM VCM PEAKS FOR 5 MINUTES EACH IN THE RHESUS MONKEY, THE AUTHORS CONCLUDED THAT REGARDLESS OF THE EXPOSURE PROFILE THE AMOUNT OF REACTIVE METABOLITES FORMED FROM VCM WOULD SOLELY BE A FUNCTION OF MEAN VCM CONCENTRATION (AIR) OVER TIME. DESCRIPTORS xxxxxxk VCM)INHALATION{PHARMACOKINETICS{METABOLISMjMOFKEY HELD TERMS PEAK CONCENTRATIONS)RHESUS MONKEY) ARCH TOXICOL) REVIEW YEAR 1990 Item 325 ACCESSION NUMBER 677 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT PHARMACOKINETICS OF VINYL CHLORIDE IN THE RAT AUTHOR/AFFILIATION BOLT HM,NONE{LAIB RJ,NONE)KAPPUS HNONE)BUCHTER A,NONE) ORIGIN NONE,VOL 7 PP.179-188) DATE 1977 ABSTRACT PHARMACOKINETIC ANALYSIS SHOWS THAT NO SIGNIFICANT CUMULATION OF VINYL CHLORIDE OR ITS MAJOR METABOLITES IS TO BE EXPECTED ON REPEATED ADMINISTRATION OF VINYL CHLORIDES. THIS MAY BE CONSISTENT WITH THE THEORY THAT A REACTIVE,SHORTLY LIVING,METABOLITE MUCH OCCURS IN LOW CONCENTRATION ONLY, MAY BE RESPONSIBLE FOR THE TOXIC EFFECTS OF VINYL CHLORIDE. DESCRIPTORS xxxxxxx VCM)PHARMACOKINETICS)METABOLISM)RAT)INHALATION HELD TERMS TOXICOLOGY)INSTITUTE OF TOXICOLOGY{UNIV OF TUBINGEN)INSTITUTE OF OCCUPATIONAL AND SOCIAL MEDICINE{UNIV OF COLOGNE) REVIEW YEAR 1990 Item 326 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE 676 GEN PUBLICATION DISPOSITION OF (1>2-14C) VINYL CHLORIDE IN RAT BOLT HMNONE)KAPPUS H,NOW)BUCHTER A,NONE)BOLT H,NONE) NONE,VOL 35 NO.3 PP.153-162) 1976 DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAI6 ELGUT Order number 911001-135640-WIZ -001-007 page 108 set 13 with 374 of 374 items ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR IMMEDIATELY AFTER EXPOSURE, HIGHEST RADIOACTIVITY LEVELS HERE OBSERVED IN LIVER AND KIDNEY. THE RADIOACTIVE METABOLITES OF 14C-VINYL CHLORIDE HERE RAPIDLY EXCRETED, LARGELY BY THE KIDNEYS. EXCRETION OF RADIOACTIVITY IN THE URINE HAS 69.4 PLUS OR MINUS 2.6 X WITHIN 24 HR. xxxxxxx VCM)INHALATION)METABOLISM)RAT DISPOSITION) ARCH TOXICOL) 1990 Item 327 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 675 GEN PUBLICATION PHARMACOKINETICS OF VINYL CHLORIDE IN THE RHESUS MOMCEY BUCHTER A,NONE)FILSER JG,NONE)BOLT HM.NONEJPETER H,N0NE) NONE,VOL 6 PP.33-36) 1980 THE METABOLIC ELIMINATION OF VINYL CHLORIDE IN RHESUS MONKEYS IS A DOSE-DEPENDENT,SATURABLE PROCESS, AS IN RATS. BELOH 200-300 PPM OF VINYL CHLORIDE (VC) IN ATMOSPHERE, ELIMINATION OBEYS A FIRST-ORDER LAN) THE CLEARANCE RATE IS MUCH CLOSER TO THAT FOUND IN HAN THAN THE VALUES FOR RATS, MICE AND GERBILS. THE MAXIMAL VELOCITY OF METABOLIC ELIMINATION OF VC AT HIGH CONCENTRATIONS IN RHESUS MOMtEYS IS ONLY ABOUT HALF OF RATS WHEN RELATED TO KG BODY HEIGHT. IT IS SUGGESTED THAT RHESUS MOWEYS MIMIC THE QUANTITATIVE ASPECTS OF VC METABOLISM BETTER THAN RATS OR MICE. VCM ) INHALATION )M0tKEY) PHARMACOKINETICS )METABOLISM RHESUS MONtEY)TOXICOLOGY LETTERS) 1990 Item 328 ACCESSION NUMBER 674 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT STUDIES ON THE METABOLISM OF VINYL CHLORIDE AUTHOR/AFFILIATION ANTNEILER H,NONE) ORIGIN NONE,VOL 17 PP.217-219) DATE 1976 ABSTRACT VINYL CHLORIDE (VCM) IS NOT CARCINOGENIC BY ITSELF IT IS BIOACTIVATEO TO THE HIGHLY REACTIVE ALKYLATING OXIRANE CHLOROETHYLENE OXIDE. FURTHER METABOLISM, APPARENTLY, LEADS VIA AN INTERACTION OF THE PRIMARY ALKYLATING METABOLITES KITH GLUTATHION TO S-(2-CARBOXYMETKYL)-CYSTEINE AND THIODIACETIC ACID WHICH ARE ELIMINATED WITH THE URINE. DESCRIPTORS ******* VCM)METABOLlSM HELD TERMS S-(2-CARBOXYMETHYL)-CYSTEINEENVIRONMENTAL HEALTH PERSPECTIVES) CHLOROETHYLENE OXIDE) THIODIACETIC ACID) REVIEW YEAR 1990 Item 329 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT 673 GEN JOURNAL RISKS TO THE OFFSPRING FROM PARENTAL OCCUPATIONAL EXPOSURES *"7? c0 G\ c* \n O DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order rmfcer 911001-135640-NIZ -001-007 page 109 set 13 with 374 of 374 items AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS xxxxxxx REVIEW YEAR HAAS JF,NONE)SCHOTTENFELD D,N0NE> JOURNAL OF OCCUPATIONAL MEOICINE ,VOL 21 NO.9 PP.607-613* 1979, SEPTEMBER VCM IS DISCUSSED AS ONE OF SEVERAL COMPOUNDS WHICH NAY POSE A REPRODUCTIVE RISK. VCHiREPRODUCTION{TERATOGENICITY)MUTAGENICITY)HUMAN)EFFECTS^CHROMOSOMAL ABERRATION 1990 Item 330 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 672 GEN PUBLICATION THE ROLE OF RESPIRATION IN VINYL CHLORIDE MONOMER EXCRETION IN RATS ZUCCATO E,N0NE{MARCUCCZ F,NONE)MUSSINI E,N0NE) NONE,VOL 5 PP.213-217 1980 1,5 AND 10 MG/KG VINYL CHLORIDE MONOMER (VCM) IN AQUEOUS SOLUTION HERE INJECTED I.V. INTO MALE RATS WITH CAMAJLATED TRACHEAS. RESPIRATORY ACTIVITY HAS REGULATED TO PERMIT INVESTIGATION OF THE EFFECT OF MODIFYING PULMONARY VENTILATION ON VCM EXCRETION IN BLOOD AND EXPIRED AIR ASSAYED AT DIFFERENT INTERVALS FOR VCM. VCM EXCRETION RATE NAS FOUND TO BE DIRECTLY PROPORTIONATE TO PULMONARY VENTILATION. WHEN RESPIRATION NAS STOPPED FOR 1 HIN AFTER VCH INJECTION, THERE HAS NO DECREASE IN BLOOD VCM, THE MAIN ROUTE OF ELIMINATION OF I.V. INJECTED VCM THUS BEING PULMONARY. VCM)LUNGS)RATS)IV)ELIMINATION DISPOSITION)TOXICOLOGY LETTERS) 1990 Item 331 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS xkxxxj REVIEW YEAR 671 GEN PAPER METABOLISM OF VINYL CHLORIDE NATANABE PG,DOH CHEMICAL CO)HEFNER R,SAME)MCGOHAN GR,SAME)GEHRING PJ,SAME) DOW CHEMICAL CO,PRESENTED AT COMBINED CLINICAL STAFFS (NIH)) 1974, NOVEMBER 14 VCM (INHALATION {METABOLISM 1990 Item 332 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 670 GEN PAPER VINYL CHLORIDE INDUCED DEPRESSION OF HEPATIC NON-PROTEIN SULFHYDRYL CONTENT AND EFFECTS ON BROMOSULPHALEIN (BSP) HATANABE PG,OOH CHEMICAL CO)HEFNER RE,SAME)GEHRING PJ,SAME) DOW CHEMICAL CO 1976 RATS HERE EXPOSED TO ATMOSPHERES OF 2000,1000,250,150,50 AND 10 PPM VINYL CHLORIDE (VC) FOR 1-7 HOURS TO DETERMINE THE EFFECT OF VC ON THE HEPATIC NON-PROTEIN SULFHYDRYL CONTENT. EXPOSURE TO >w -* 00 vn O *0 DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order nuttfcer 911001-135640-HIZ -001-007 page 110 set IS with 374 of 374 items DESCRIPTORS HELD TERMS REVIEH YEAR 2000,1000,250 AND 150 PPM VC CAUSED A PROGRESSIVE DEPRESSION OF THE HEPATIC NON-PROTEIN SULFHYDRYL CONTENT. FOLLOWING EXPOSURE TO 50 PPM VC FOR 7 HOURS THE DEPRESSION NAS INCONSISTENT, AND NO DEPRESSION HAS OBSERVED AFTER 10 PPM VC FOR 7 HOURS. ALSO, EXPOSURE TO 1000 PPM VC DID NOT ALTER THE SERUM CLEARANCE OF BROMSULPHALEIN (BSP) xxxxxxx VCMjINHALATIONjRATSjMETABOLISM DISPOSITION {CLEARANCE> 1990 Item 333 ACCESSION NUMBER 669 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT HEPATIC MACROMOLECULAR BINDING FOLLOHING EXPOSURE TO VINYL CHLORIDE AUTHOR/AFFILIATION HATANABE PG,DOW CHEMICAL CO{ZEMPEL JA,SAME}PEGG DGSAME)6EHRING PJ.SAME} ORIGIN TOX AND APPLIED,VOL 44 PP.571-579} DATE 1978 ABSTRACT COVALENT BINDING OF RADIOACTIVITY TO HEPATIC MACROMOLECULES IN RATS EXPOSED TO 14C-LABELED VINYL CHLORIDE (VC) HAS STUDIED TO DETERMINE IF VC-INDUCED CARCINOGENESIS MAY BE RELATED TO ELECTROPHILIC ALKYLATION OF MACROMOLECULES ZN VIVO. HALE SPRAGUE-DAHLEY RATS HERE EXPOSED TO 1,10, 25,50,100,250,500,1000, OR 5000 PPM OF 14C VC FOR 6 HR. FOLLOHING EXPOSURE,RADIOACTIVITY COVALENTLY BOUND TO HEPATIC MACROMOLECULES AND PURIFIED NUCLEIC ACID (RNA,0NA) HAS DETERMINED. THE TOTAL AMOUND OF 14C VC METABOLIZED AND HEPATIC GLUTATHIONE (GSH) CONTENT HERE ALSO DETERMINED. THE TOTAL AMOUNT OF RADIOACTIVITY BOUND TO HACRQMOLECULES IN THE LIVER DID NOT INCREASE PROPORTIONATELY TO THE INCREASE IN THE EXPOSURE CONCENTRATION OF VC. A OISPROPORTXONATE DECREASE IN MACROMOLECULAR BINDING HAS OBSERVED AS THE CONCENTRATION OF VC INCREASED. THE COVALENT BINDING TO HEPATIC MACROMOLECULES HAS RELATED TO THE AMOUNT OF VC METABOLIZED. AT EXPOSURES GREATER THAN 50PPM, THE AMOUNT OF 14C BOUND TO MACROMOLECULES IN THE LIVER CORRELATES WITH INDUCTION OF HEPATIC ANGIOSARCOMA. THERE NAS NOT DETECTABLE BINDING OF RADIOACTIVITY TO EITHER DMA OR RNA IN THE LIVER. HEPATIC GLUTATHIONE CONTENT HAS SIGNIFICANTLY DEPRESSED ONLY AT EXPOSURE CONCENTRATIONS GREATER THAN 100PPM. DESCRIPTORS xxxxxxx VCH (METABOLISM} LIVER} INHALATXON}RATS HELD TERMS MACROMOLECULAR BINDING}COVALENT BINDING REVIEH YEAR 1990 Item 334 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORSxxxxxxx HELD TERMS REVIEW YEAR 666 GEN PUBLICATION A PROCEDURE FOR PREPARING 14C-LABELED VINYL CHLORIDE HAGNER ER,NONE}MUELDER HH,NONE} NONE,VOL 246PP.152-153} 1975, JANUARY 31 VCH SYNTHESIS {RADIOLABELED {AMALS OF THE NEN YORK ACADEMY OF SCIENCES 1990 22521110 ;G 5 2 9 ^ DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order number 9U001-135640-NIZ -001-007 page 112 set 13 with 374 of 374 items AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** HELD TERMS REVIEW YEAR GEHRING PJ,DOH CHEMICAL CO! DOW CHEMICAL CO,FOR HEARING ON EPA'S PROPOSED STANDARD FOR VINYL CHLORIDE! 1976, FEBRUARY 2 USE OF PHARMACOKINETICS IN RISK ASSESSMENT. EXTRAPOLATION OF RODENT DATA TO MAN. VCM AN EXAMPLE. VCM}INHALATION (CARCINOGENICITY iRATSlHUIANS INCIDENCE>LOW DOSE EXTRAPOLATION 1990 Item 339 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 663 GEN JOURNAL ACRQ-OSTEOLYSIS OCCURRING IN MEN ENGAGED IN THE POLYMERIZATION OF VINYL CHLORIDE HARRIS DK,ICl!ADAMS WGF,SAME! NONE,VOL 3 PP.712-714! 1967 TWO CASES OF ACRO-OSTEOLYSIS OCCURRING IN HEN ENGAGED IN THE POLYMERIZATION OF VINYL CHLORIDE ARE DESCRIBED. THE BONES AFFECTED HERE THE TERMINAL PHALANGES OF THE FINGERS AND THE SACROILIAC JOINTS, BUT IN ONE CASE THE PATELLA AND IN THE OTHER THE PHALANGES OF THE FEET HERE INVOLVED. THE CONDITION HAS ACCOMPANIED BY RAYNAUD *S PHENOMENON AND SKIN LESIONS. IT MOULD SEEM THAT THIS CONDITION IS PROBABLY A SELF-LIMITING DISEASE. ACROOSTEOLYSIS!VCM!HUMAN!EFFECTS BRITISH MEDICAL JOURNAL 1990 Item 340 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 647 GEN BOOK PERCUTANEOUS ABSORPTION OF VINYL CHLORIDE HEFNER RE,NONE!HATANABE PG,NONE>GEHRING PJ,NONE> TOX AND APPLIED,VOL 34 PP.529-532! 1975 PERCUTANEOUS ABSORPTION OF 14C-LABELED VINYL CHLORIDE (VC) NAS EXAMINED IN MALE RHESUS MONKEYS. TWO MONKEYS HERE EXPOSED (HHOLE BODY, EXCLUDING THE HEAD) TO ATMOSPHERES CONTAINING 7000 AND 800 PPM OF VC FOR 2.0 AND 2.5 HR,RESPECTIVELY. THE AMOUNT OF VC ABSORBED AT 7000 AND 800 PPM HAS 0.023 AND 0.31* OF THE RESPECTIVE TOTAL VC AVAILABLE FOR ABSORPTION. THE MAJORITY OF THE VC ABSORBED HAS ELIMINATED BY THE LUNGS. VCM*ABSORPTION>SKIN ATMOSPHERIC EXPOSURE jPERCUTANEOUS 1995 Item 341 ACCESSION NUTOER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT 646 GEN PUBLICATION HEPATIC LESIONS CAUSED BY VINYL CHLORIDE MONOMER IN HUMANS: STUDY OF EIGHT CLINICOPATHOLOGICAL BFG52989 * - -f DATA SEARCH ON VCM/TOXIdTY STUDIES FOR CRAIG ELGUT Order nunber 911001-135640-HIZ -001-007 page 113 set 13 with 374 of 374 itens BFG52990 CASES AUTHOR/AFFILIATION PIALAT J NONE)PASRUIER B,NONE)PAHNH>NONE)KOPPN#NONE) ORIGIN NONE#VOL 27 NO.6 PP.341-375) DATE 1979 ABSTRACT SIX HEPATIC ANGIOSARCOMAS> ONEHEPATOMA AND ONE HEPATIC FIBROSIS WITH PORTAL HYPERTENSION IN PATIENTS CHRONICALLY EXPOSED TO VINYL CHLORIDE MONOMER (VCM) ARE REPORTED. THE INDUSTRIAL METHODS OF SYNTHESIS AND CURRENT KNOHLEDGE CONCERNING THE CARCINOGENIC ROLE OF VCM ARE REVIEWED. HISTOGENETXC AND PATHOGENETIC CONCETPS OF FIBROSIS AND ANGIOSARCOMAS OF LIVER ARE EXPOSED. DESCRIPTORS ******* VCM)ANGIQSARCOMA)LIVER)CANCER)HUMAN)EFFECTS HELD TERMS ARCH ANAT CYTOL PATH REVIEW YEAR .1990 Item 342 ACCESSION NUMBER 619 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT INVESTIGATION OF THE DISEASES PRODUCED BY VINYL CHLORIDE AUTHOR/AFFILIATION SUCIU I,NONEj ORIGIN NONE#VOL 15 PP. 967-78) DATE 1963# AUGUST DESCRIPTORS xxxxxxa VINYL CHLORIDEjTOXICITY HELD TERMS LIVER DAMAGE)MEDICINA INTERNA (BUCHAREST)) INSTITUTE OF HYGIENE OF CLUJ) COMMENTS WJ(84) CLASSIC EARLY PAPER ASSOCIATING VCM EXPOSURE KITH BOTH LIVER AND SCLERODERMAL LIKE EFFECTS. REVIEW YEAR 1990 Item 343 ACCESSION NUTOER 616 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT ANGIOGRAPHIC AND RADIONUCLIDE CHARACTERISTICS OIF HEPATIC ANGIOSARCOMA FOUND IN VINYL CHLORIDE WORKERS AUTHOR/AFFILIATION WHELAN JG#UNIV OF LOUISVILLE)CREECH JL#NONE)TAh6URRO CH#NONE) ORIGIN NONE#VOL 116 NO.3 PP.549-557) DATE 1976, MARCH DESCRIPTORS xxxxxxx VINYL CHLORIDE)ANGIOSARCOMA)LIVER HELD TERMS ANGIOGRAPHY)LIVER SCANS)RADIOLOGY REVIEW YEAR 1990 Item 344 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE 600 GEN JOURNAL THE PATHOLOGY OF 111 CAES OF PRIMARY HEPATIC MALIGNANCY COLLECTED IN THE LIVERPOOL REGION CRUICKSHANC AH,NONE) NONE,VOL 14 PP.120-131) 1961# MARCH ** DATA SEARCH ON VCH/TOXICITY STUDIES FOR CRAIG ELGUT Order number 911001-135640-WIZ -001-007 page 114 set 13 with 374 of 374 items ABSTRACT DESCRIPTORS HELD TERNS REVIEW YEAR THE CLINICAL RECORDS AND PRESERVED SPECIMENS OF 111 CASES OF PRIMARY MALIGNANT DISEASE OF THE LIVER HAVE BEEN ANALYSED. ALL WERE DIAGNOSED IN THE MERSEYSIDE AREA) CHIEFLY IN LIVERPOOL AND BIRKENHEAD) AND ALL BUT NINE HERE EUROPEANS. NECROPSY HAS DONE IN 89. THE TUMOURS CONSISTED OF 108 CARCINOMAS, TWO SARCOMAS, AND ONE MIXED TUMOUR. LIVER CELL CARCINOMA WAS NEARLY FOUR TIMES MORE FREQUENT THAN CARCINOMA OF THE INTRAHEPATIC BILE DUCTS. BOTH TYPES HERE COMMONER IN KALES, THE DIFFERENCE BETWEEN THE SEXES BEING GREATER IN THE CASE OF LIVER CELL CARCINOMA. PREDISPOSING CONDITIONS INCLUDED PORTAL CIRRHOSIS, HAEMOCHROMATOSIS, AND CYSTIC MALFORMATIONS OF BILE DUCTS. THE GROSS AND MICROSCOPIC APPEARANCES ARE DESCRIBED AND THE PATHOLOGICAL EFFECTS DISCUSSED. LIVER CELL CARCINOMA TENDS TO INVADE AND PERMEATE VEINS WITHIN THE LIVER BUT SEEMS, NEVERTHELESS, TO REMAIN LIMITED TO THE LIVER FOR LONGER THAN CARCINOMA OF THE INTRAHEPATIC BILE DUCTS. LIVER CELL CARCINOMA IS MORE CHARACTERISTIC MICROSCOPICALLY. THE COMMONEST OCCUPATION AMONG THE MALE CASES WAS SEAFARER. VCMiLIVER)CANCER)HUMAN)E FFECTS J.CLIN.PATH.lUNIV OF LIVERPOOL) 1990 Item 345 ACCESSION NUMBER 599 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT OCCUPATIONAL ACROQSTEOLYSIS - A CLINICAL INVESTIGATION OF POLYVINYL CHLORIDE SYNTHESIS WORKERS AUTHOR/AFFILIATION DINMAN BD,UNIV OF MICHIGANlDODSON VN,SAME)MAGNUSON HJ,SAME)WHITEHOOSE Mi, SAME) ORIGIN UNKNOW DATE 1969 f DESCRIPTORS ***** REVIEW YEAR VCM*AOLHUMAN)EFFECTS 1990 Item 346 I - ACCESSION NUMBER 595 FILE LOCATION GEN DOCUMENT TYPE JOURNAL *** TITLE OR SUBJECT AUTHOR/AFFILIATION MUTAGENICITY OF VINYL CHLORIDE,VINYLIDENE CHLORIDE AND CHLOROPRENE IN V79 CHINESE HAMSTER CELLS DREVON C,NONEiKUROKI T,SAME) ORIGIN NONE>VOL 67 PP.173-182) DATE 1979 ABSTRACT VCM HAS MUTAGENIC BUT VDC AND CHLOROPRENE WERE NOT. & DESCRIPTORS x*x*xx VCM>MUTAGENICITY)IN VITRO jCHLOROPRENE)VDC HELD TERMS IARC) MUTATION RESEARCH) REVIEW YEAR 1990 Item 347 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT 594 GEN JOURNAL CARCINOGENICITY OF CHLOROETHYLENE OXIDE,AN ULTIMATE REACTIVE METABOLITE OF VINYL CHLORIDE, AND BIS(CHLOROMETHYL JETHER AFTER SUBCUTANEOUS ADMINISTRATION AND IN INITIATION-PROMOTION EXPERIMENTS IN MICE BFG52991 > t DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order number 911001-135640-WIZ -001-007 page 116 set 13 with 374 of 374 items DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 1981 IT IS CONCLUDED THAT THE COMPOUND DESCRIBED BY THESE AUTHORS, 7-N-{2-OXOETHYL)GUANINE IS IN FACT THE MAJOR PRODUCT OF BASE ALKYLATION IN DNA AFTER EXPOSURE TO VINYL CHLORIDE. VCM )DNA>INHALATION> RATS)LIVER 7-N-(2-OXOETHYL)QUANINE)ALKYLATION> UNIV OF MAINZ <GERMANY))CHEM. BIOL. INTERACTIONS) 1990 Item 3S1 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** HELD TERMS REVIEW YEAR 590 GEN JOURNAL ROLES OF 2-HALOETHYLENE OXIDES AND 2-HALOACETALDEHYDES DERIVED FROM VINYL BROMIDE AND VINYL CHLORIDE IN IRREVERSIBLE BINDING TO PROTEIN AND DNA GUENGERICH FP,NONE)MASON PS,SAME)STOTT WT,D0M CHEMICAL CO)FOX TR> SAME)HATANABE PG,SAME) CANCER RESEARCH,VOL 41 PP.4391-4398) 1981, NOVEMBER VCM)DNA )CHLOROACETALDEHYDE IRREVERSIBLE BINDING)COVALENT BINOING)CHLOROETHYLENE OXIDE) BROMOACETALDEHYDE) VANDERBILT UNIV) 1990 Item 352 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ***** HELD TERMS REVIEW YEAR 589 GEN JOURNAL MUTAGENICITY IN VITRO AND POTENTIAL CARCINOGENICITY OF CHLORINATED ETHYLENES AS A FUNCTION OF METABOLIC OXIRANE FORMATION GREIM H>NONE)BONSE G,NONE)RADHAN Z,NONE)REICHERT D,NONE)HENSCHLER D>N0NE) NONE,VOL 24 PP.2012-2017) 1975, JULY VCM)TETRACHLOROETHYLENE)TRICHLOROETHYLENE)ETHYLENE DICHLORIDE)MUTAGENICITY) IN VITRO)OXIRANE EPOXIDES)CHLORINATED ETHYLENES)CHLORINATED HYDROCARBONSjBIOCHEMICAL PHARMACOLOGY 1990 Item 353 ACCESSION NUMBER 88 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT AUTHOR/AFFILIATION REACTIVE METABOLITES AND CARCINOGENICITY OF HALOGENATED ETHYLENES BOLT HM,NONE)LAIB RJ,NONE)FILSER JG,NONE) ORIGIN NONE,VOL 31 NO.l PP.1-4) DATE 1982 ABSTRACT COVALENT BINDING,METABOLISM AND MUTAGENICITY OF VCM,VINYL FLUORIDE,VINYL IDENE FLUORIDE, VINYLIDENE CHLORIOE,EDO,TRICHLOROETHYLENE, PERCHLOROETHYLENE,VINYL BROMIDE. DESCRIPTORS xxxxxxx VCM)VINYLIDENE CHLORIDE)ETHYLENE DICHLORIDE)TRICHLOROETHYLENE)PERCHLOROETHYLENE)MUTAGENICITY) METABOLISM HELD TERMS COVALENT BINDING) VINYL FLUORIDE)VINYLIDENE FLUORIDE)EDC)VINYL BROMIDE) TCE)BIOCHEMICAL PHARMACOLOGY) -t S -f f -? ~ jl J- L> <2l cl vA O I i DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order number 9Z1001-135640-HIZ -001-007 pays 117 set 13 with 374 of 374 items <r?! f ifw REVIEH YEAR 1990 Item 354 ACCESSION NUTCER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEH YEAR 587 GEN RESEARCH LAB REPORT LIFE-SPAN ORAL TOXICITY STUDY OF VINYL CHLORIDE IN RATS FERON VJ>NONE)HENDRIKSEN CFM,NONE)SPEEK AJNONE>TIL HP,NONE)SPXT BJ, NONE) NONE,REPORT N0.R-5788> 1978, OCTOBER THE CARCINOGENICITY OF VCM <IN PVC AND BY INTUBATION NAS STUDIED. A VARIETY OF NEOPLASTIC AND NON-NEOPLASTIC VCM-RELATED LIVER LESIONS NERE FOUND IN EACH OF THE TEST GROUPS. HEPATIC ANGIOSARCOMAS OCCURRED AT LEVELS OF 5.0 MG/KG AND HIGHER. HEPATOCELLULAR TUMOURS (NEOPLASTIC NODULES AND CARCINOMAS) HERE FOUND IN ALL DOSE-GROUPS. THEIR INCIDENCE HAS HIGH IN BOTH SEXES OF THE 14.1 MG/KG GROUP AND IN FEMALES OF THE 1.7 AND 5.0 MG/KG GROUPS, LON IN MALES OF THE 5.0 MG/KG GROUP, AND MARGINAL IN MALES OF THE 1.7 MG/KG GROUP. PULMONARY ANGIOSARCOMAS (MAINLY METASTASES) AND A FEW EXTRAHEPATIC INTRA- ABDOMINAL ANGIOSARCOMAS NERE OBSERVED AT LEVELS OF 5.0 MG/KG AND HIGHER. A FEH ZYMiAL GLAND TUMOURS OCCURRED AT THE 5.0 AND 300 MG/KG LEVELS. THERE HAS SOME INDICATION THAT VCM MAY ENHANCE THE DEVELOPMENT OF BOTH INTRA-ABDOMINAL MESOTHELIOMAS AND ADENOCARCINOMAS OF THE MAMMARY GLANDS. THE TUMOUR RESPONSE OF THE LIVER OF THE RAT TO ORAL INTAKE OF VCM SEEMS TO SHIFT FROM ALMOST EXCLUSIVELY ANGIOSARCOMA AT VERY HIGH LEVELS TO EXCLUSIVELY HEPATOCELLULAR TUMOURS AT LOW LEVELS. VCM>RATS)CHRONIC )CARCINOGENICITY)ANGIOSARCOMA)ADENOMA)ZYMBAL GLAND)MAMMARY GLAND)MESOTHELIOMA) TUMORS CENTRAL INSTITUTE FOR NUTRITION AND FOOD RESEARCH) 1995 Item 355 ACCESSION NUMBER 586 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT VINYL CHLORIDE: AN EXAMPLE FOR EVALUATING MUTAGENIC EFFECTS IN MAMMALS IN VIVO AFTER EXOPSURE TO INHALATION AUTHOR/AFFILIATION BASLER ANONE)ROHRBORN 6,NONE) ORIGIN NONE,VOL 45 PP.l-7> DATE 1980 ABSTRACT AS PART OF A PROGRAMS OF INVESTIGATIONS ON THE MUTAGENIC EFFECTS IN MAMMALS IN VIVO AFTER INHALATION OF ENVIRONMENTAL CHEMICALS, THE EFFECTS OF THE INDUSTRIAL COMPOUND VINYL CHLORIDE (VC) HAS ANALYSED. CHINESE HAMSTERS HERE EXPOSED TO 1.25*>2.5Z OR 5X(V/V) VC IN AIR FOR 6,12 OR 24 H. BONE MARROH CHROMOSOMES HERE ANALYSED FOR INDUCED CHROMOSOME ABERRATIONS ANO SISTER-CHROMATID-EXCHANGES ISCES) 26 HR AFTER BEGINNING OF EXPOSURE. THE FREQUENCY OF VC- INDUCED CHROMOSOME ABERRATIONS AND SCES BOTH DEPEND ON DOSE AND LENGTH OF EXPOSURE. THE HIGHEST MEASURED EFFECTS WERE 33.25 SCES/CELL AFTER EXPOSURE TO 2.5X VC FOR 24 H AND 25.TA METAPHASES HITH ABERRATIONS, WHEN EXPOSED TO 5Z VC FOR 24 H. DESCRIPTORS xxxxxxx VCM)MUTAGENICITY)BGNE MARROH^CHROMOSOMAL ABERRATION)HAMSTERS)INHALATION HELD TERMS SCE}SZSTER CHROMATID EXCHANGE)ARCH TOXICOL REVIEH YEAR 1995 4 ^ <3f O' o\ cX o OATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order ntiiber 911001-135640-HIZ -001-007 page 116 set 13 with 374 of 374 items Item 356 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** HELD TERMS REVIEW YEAR 564 GEN JOURNAL REACTIONS OF VINYL CHLORIDE KITH RNA AND DNA OF VARIOUS MOUSE TISSUES IN VIVO BERGMAN K,NONE} NONE,VOL 49 PP.117-129} 1982 THE AUTHORS REPORT THE IRREVERSIBLE BINDING OF VCM KITH THE RNA AND DNA OF SEVERAL TISSUES VCM}DNA}MICE RNA}ALKYLATION}IRREVERSIBLE BINDING }UNIV OF UPPSALA (SWEDEN)} ARCH TOXICOL} 1995 Item 357 ACCESSION NUMBER 563 FILE LOCATION GEN DOCUMENT TYPE TRADE ASSOCIATION REPORT TITLE OR SUBJECT FINAL REPORT OF AUDIT TASK GROUP ON LIFETIME INHALATION STUDY ON VINYL CHLORIDE AT INDUSTRIAL BIO-TEST LABS, INC. AUTHOR/AFFILIATION NONE>NONE} ORIGIN CMA DATE 1978 DESCRIPTORS xxxxxxx VCM)INHALATION}RATS}MICE}HAMSTERS}CARCINOGENICITY}CHRONIC HELD TERMS AUDIT} REVIEW YEAR 1990 Item 356 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN OATE ABSTRACT DESCRIPTORS xxxxxxx HELD TERMS REVIEW YEAR 582 GEN RESEARCH LAB REPORT VINYL CHLORIDE PATHOLOGY REPORT NONE,NONE} NONE,FOR MCA} 1979, JANUARY 9 AUDIT PATHOLOGY REPORT OF LONG-TERM INHALATION STUDY OF VCM AT IBT VCN)INHALATTON}RATS}MICE}HAMSTERS}CARCINOGENICITY}CHRONIC PATHOLOGY EXPERIMENTAL PATHOLOGY LABS} 1990 Item 359 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT 581 GEN TOXICITY STUDY CHRONIC VAPOR INHALATION TOXICITY STUDY KITH VINYL CHLORIDE (ETHYLENE DERIVED) IN ALBINO RATS, ALBINO MICE AND GOLDEN HAMSTERS-- 23-MONTH STATUS SUMMARY TO MCA r-'<T % ; 1 \ DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order runber 911001-135640-HIZ -001-007 f pege 119 set 13 with 374 of 374 items * AUTHOR/AFFILIATION NONE,NONE) ORIGIN INDUSTRIAL DIO-TEST LABS*IDT NO. 663-03222) DATE 1975, SEPTEMBER 23 ABSTRACT THIS 23-MONTH STATUS REPORT (9/10/73-9/10/74) IS THE LAST REPORT RECEIVED FROM IBT. NO FINAL REPORT HAS EVER PROVIDED. SEE EXPERIMENTAL PATHOLOGY LABSBOD NEST +ASSOCIATES, AND AUDIT GROUP REPORTS. DESCRIPTORS hhhh VCM)INHALATION)CARCINOGENICITY>CHRONIC)RATS)MICE)HAMSTERS REVIEW YEAR 1990 Item 360 ACCESSION NUMBER FILE LOCATION sad < SEN''' DOCUMENT TYPE TOXICITY DATA TITLE OR SUBJECT CHRONIC VAPOR INHALATION TOXICITY STUDY WITH VINYL CHLORIDE ALfTKOR/AFFILIATION NONE,NONE) ORIGIN INDUSTRIAL BIO-TEST LABS,FOR CMAl DATE 1973, FEBRUARY ABSTRACT PROTOCOL FOR LONG-TERM INHALATION STUDY KITH VINYL CHLORIDE SPONSORED BY CMA (MCA) AT INDUSTRIAL BIO-TEST LABS. DESCRIPTORS mkmmxkm VCM)INHALATION)CARCINOGENICITY)CHRONIC)RATS)MICE)HAMSTERS REVIEW YEAR 1990 Item 361 ACCESSION NUISER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS REVIEW YEAR GEN CORRESPONDENCE PROTOCOL AMENDMENTS ANO COffiUNICATION FOR THE VCM LONG-TERM INHALATION STUDY NONE,NONE) INDUSTRIAL BIO-TEST LABS,FOR CMA) 1973, TO 1978 PROTOCOL AMENDMENTS AND COMMUNICATIONS REGARDING THE LONG-TERM INHALATION STUDY WITH VINYL CHLORIDE SPONSORED BY CHA(MCA) AND CONDUCTED AT INDUSTRIAL BIO-TEST LABORATORIES. INHALATIQN>CARCINOGENXCITY)CHRONIC)RATS)MICE)HAMSTERS)VCH 1990 Item 362 ACCESSION NUMBER FILE LOCATION OOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILXATION ORIGIN DATE DESCRIPTORS whhhh HELD TERMS REVIEW YEAR 573 GEN PUBLICATION VINYL HALIDES CARCINOGENICITY NONE,NONE) NIOSH,ANO OSKA CURRENT INTELLIGENCE BULLETIN NO.26) 197B, SEPTEMBER 21 j VINYL CHLORIDEJVINYLIDENE CHLORIDE)HUMAN)ANIMAL CARCINOGEN) CARCINOGENICITY>MUTAGENICITY) REPRODUCTION )EFFECTS VINYL BROMIDE) 1990 .- j/"* ' X.^ei % % OATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT' Ordar rMabar 911001-13S640-KI2 -001-007 * paga 120 *t IS with 374 of 374 itam Itan 365 ACCESSION MAKER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFF1 LXATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERNS COtfENTS REVIEW YEAR 546 GEN JOURNAL CARDIOVASCULAR DISEASE AND ENVXROtttENTAL EXPOSURE ROSENHAN KD,NONE> NONE,VOL 36 PP.85-97) 1979 THIS PAPER REVIEWS THE POSSIBLE ASSOCIATION BETWEEN CARDIOVASCULAR DISEASE AND OCCUPATIONAL AND ENVIRONMENTAL AGENTS. THE EFFECTS OF CARBON MONOXXOE.FIBROGENXC DUSTS, CARBON DISULPHIDE,HEAVY METALS, NQSIE,RADIATION,HEAT,COLD.SOLVENTS AND FLUOROCARBONS ARE DISCUSSED. NOISE,RADIATION,HEAT, COLD .SOLVENTS AND FLUOROCARBONS ARE DISCUSSED .NEHDIRECTXONS FOR INVESTIGATION ARE SUGGESTED. HEART(CARBON MONOXIDE(DUST)CARBON DISULFIDE(NITRATES(ANTINONY)CADMIUM( LEA0(CC6ALT(MERCURY(00161( VINYL CHLORIDE (NOISE )HYPERTENSION(METHYLENE CHLORIDE ( RADIATION) FLUOROCARBONS (CIGARETTE SMOKE ATHEROSCLEROSIS(HYPOCALCAEMIA(ARRHYTHMIA)POLONIUM 210(ELECTROMAGNETIC RADIATION (LEAD 210) CARDIOVASCULAR DISEASE(GLYCERYL TRINITRATE) ETHYLENE GLYCOL DXNITRATE(EXPLOSIVES(CARDIOMYOPATHY) MOUNT SINAI SCHOOL OF MEDICINE(BRITISH J OF INDUSTRIAL MEDICINE) BLH(64) GOOD GENERAL ARTICLE ON POSSIBLE ENVIRONMENTAL CAUSES OF HEART DISEASE HITH MANY REFERENCES CITED. 1969 Xtan 364 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AF FILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** REVIEW YEAR 470 GEN REPORT ETHENE, CHLORO, (CASS 75-01-4)1 BFG TSCA INVENTORY SUBMISSION, FORMS A12797346, CALVERT CITY. NONE,NONE) BFG-CHEMXCAL, TO EPA( 1976 TSCA INVENTORY SUBMISSION OF VINYL CHLORIDE. DOCUMENT IN CHEMICAL GROUP ENVIRON AFFAIRS DEPT FILES. CAS.NO.75-01-4 (TSCA INVENTORY VCM 1990 Xtan 365 ACCESSION MAKER 446 FILE LOCATION GEN DOCUMENT TYPE BIBLIOGRAPHY TITLE OR SUBJECT VINYL CHLORIDE AND POLYVINYL CHLORIDE) TOXICOLOGY (1976-1983) - CITATIONS FROM THE LIFE SCIENCES COLLECTION DATA BASE AUTHOR/AFFILXATXON NONE,NOt ) ORIGIN NONE,PB84-655618( J DATE 1984 DESCRIPTORS ******* VCM(PVC) EPIDEMIOLOGY (CANCER(BIRTH DEFECTS)MUTAGENICITY (REPRODUCTION) METABOLZSM(TOXIcm DATA HELD TERMS NTIS REVIEW YEAR 1990 *7> v "'; --? -i '.ri %% DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order number 911001-135690-KIZ -001-007 page 121 set 13 with 379 of 379 items Item 366 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** HELD TERMS REVIEW YEAR 388 GEN GOVERNMENT CORR SAFETY OF PLASTIC PIPES FOR USE IN POTABLE HATER DISTRIBUTION HANSON HF,EPA) EPATO BFG-CHEMICAL) 1902 EPA POSITION STATEMENT ON PLASTIC PIPE. EPAjPVC >VINYL CHLORIDE ^MIGRATION PLASTIC PIPE)POTABLE HATER)LEACHING) 1986 Item 367 ACCESSION NLWBER 387 FILE LOCATION GEN DOCUMENT TYPE PAPER TITLE OR SUBJECT USE OF METAL AND RUSTIC PIPES IN HATER SUPPLY DISTRIBUTION SYSTEMS AUTHOR/AFFILIATION LASSOVASKY P,EPA)KHAN T>SAME) ORIGIN EPA DATE 1981 . ABSTRACT EPA POSITION PAPER ON PLASTIC PIPE AND THE OCCURRENCE OF DEHP (PLASTICIZER). ALSO DISCUSSED DISCONTINUATION OF LEAD PIPE DUE TO HEAVY METAL PROBUMS. DESCRIPTORS kxxxxxx EPAiDEHPJVINYL CHLORIDEjPVC HELD TERMS PLASTIC PIPE^POTABLE WATERtMETAL PIPE)LEACHING) REVIEW YEAR 1986 Item 368 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ***** HELD TERMS REVIEW YEAR 379 GEN TECHNICAL HAZARDS EVALUATION A RISK CONTROL SERVICES DATA GUIDES NONE>NONEJ NONE,BULLETINS HE-195-164) 1989, MARCH DETAILED FLAMMABILITY DIAGRAMS ON VARIOUS CHEMICALS. VINYL CHLORIDE )ACR0LEIN)8UTADXENE)DIQXANE)NAPHTHALENE )ANIIINE ACETALJALLYL ALCOHOLUSOAMYL ACETATEiAMYL ALCOHOLiBUTYL FORMATE) DIETHYLAMINEjETHYL PROPIONATE) PENTENE)CYMENE)ETHYLENE CHLOROHYDRIN)CHLOROBENZENE)METHYL BUTYL KETONE)METHYL PROPIONATE) FLAIflABXLXTY) HERCULES INCjBUTYL CHLORIDE) 2059 Item 369 ACCESSION NUMBER FILE LOCATION '--''GEN -1 .-< .A* DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAI6 ELGUT Order nuni>er 911001-135640-WIZ -001-007 page 122 set 13 with 374 of 374 items DOCUMENT TYPE 'RESEARCH LAB REPORT TITLE OR SUBJECT LITERATURE REVIEW OF THE POTENTIAL HAZARDS TO HUMAN HEALTH OF USING PVC AND CPVC PIPE FOR POTABLE HATER DISTRIBUTION AUTHOR/AF FI LIATION NONE N0NE ( ORIGIN SOUTHERN RESEARCH INSTITUTE>SORI-EAS-83-165 DATE ABSTRACT 1963> FEBRUARY A LITERATURE REVIEW OF POTENTIAL HEALTH HAZARDS OF PVC AND CPVC PIPE FOR POTABLE HATER USE. THIS IS NOT TERRIBLY WELL DONE. IT HAS SUBMITTED TO J OF AMERICAN HATER WORKS ASOC TRTttLGING, IT HAS SUBMITTED TO J OF AMERICAN HATER WORKS ASSOC ( R. HI LGING , +REVIEWER). PUBLICATION STATUS IS UMLCHN. DESCRIPTORS xxxxxxk PVC (CPVC(ACUTE(EFFECTS(SUBCHRONIC(SOLVENTS(MIGRATIONiFETAL TOXICITY( BENZENE(ACRYLONITRILE( TOLUENE(MUTAGENIC(TERATOGENIC(CARCINOGENICITY( VINYL CHLORIDE(CHLOROFORM(TETRACHLOROETHYLENE( TRICHLOROETHYLENE( DICHLOROETHANE(CARBON TETRACHLORIDE(TRICHLOROETHANE(STYRENE( METHYL METHACRYLATE(DEHP(THF(MEK(CHLORINE(HYDROGEN CHLORIDE( ORGANCJINSjTITANIUM OIpXipE HELD TERMS CEMENTS (METHYL STYRENE (LEACHING (PVC PIPE(PLASTIC PIPE( tlrttTt REVIEW YEAR 1986 Item 370 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 293 GEN PUBLICATION HEALTH HAZARD EVALUATION/TOXICITY DETERMINATION REPORT:GATES RUBBER COMPANY GUNTER BJ>NIOSH(LUCAS JB>NIOSH( NIOSH,REPORT NO. H.H.E. 74-61-232( 1975, NOVEMBER A PLANT MANUFACTURING EXTRUDED HOSE, PRINCIPALLY FROM THE EXTRUSION OF POLYVINYL CHLORIDE, HAS INVESTIGATED BY NIOSH TO EVALUATE EMPLOYEE EXPOSURES TO CYCLOHEXANONE, TDI,TRICHLOROETHYLENE, ESTANE R THERMO- PLASTIC POLYURETHANE, METHYLENE CHLORIDE,NIGROSINE,DI-2-ETHYL HEXYL PHTHALATE (DOP OIL], DUST,AND VINYL CHLORIDE. IT HAS DETERMINED THAT A POTENTIAL HEALTH HAZARD MAY EXIST FROM EXPOSURE TO CYCLOHEXANONE ,AND THAT SEVERAL CASES OF PRIMARY IRRITANT DERMATITIS HAD OCCURRED FOLLOWING REPEATED EXPOSURE TO SOLVENTS. ALTHOUGH ONLY ONE OF 36 VINYL CHLORIDE SAMPLES WAS FOUND TO EXCEED THE FEDERAL STANDARD ACTION LEVEL, IT HAS RECOMMENDEO THAT AIRBORNE CONCENTRATIONS BE REDUCED TO LEVELS NOT DETECTED BY THE RECOttlENDEO ANALYTICAL TECHNIQUES. PVC(CYCLOHEXANONE(TOLUENE DIISOCYANATE(TRICHLOROETHYLENE( PLASTICS(METHYLENE CHLORIDE(DEHP(VINYL CHLORIDE(DERMATITIS(PATCH TEST(EXTRUSIQNESTANES( PERSONNEL MONITORING(NIGROSINE( 1992 Item 371 ACCESSION NUMBER 205 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT AUTHOR/AFFILIATION VINYL CHLORIDE DISORDER WALKER AE,NONE> ORIGIN DATE NONEYOL 105 SUPPL.21,19( 1981, ABSTRACT BRIEF REVIEW OF MEDICAL AND EPIDEMIOLOGIC FINDINGS RELATED TO VINYL CHLORIDE IN PVC MANUFACTURE. COINAGE OF TERM VINYL CHLORIDE DISORDER. DESCRIPTORS xxxxxxx VCM(ACROOSTEOLYSIS(ANGIOSARCOMA(THROrCOCYTOPENIA(LUNGS( ZZSM.LZ2 Qjx % DATA SEARCH ON VCM/TOXICITY STUDIES FOR CRAIG ELGUT Order nunber 911001-135640-HIZ -001-007 page 123 set 13 with 374 of 374 items HELD TERMS ROYAL HOSPITAL ENGLAND(BRITISH J OF DERMATOLOGY)PVC PONDER) CHLORETHYLENE EPOXIDE)RAYNAUD'S SYNDROME(SCLERODERMA)HEPATOMEGALY) SPLENOMEGALY) Item 372 ACCESSION NLWER 61 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT THE EFFECT OF AGE AND EXPOSURE DURATION ON CANCER INDUCTION BY A KNOWN CARCINOGEN IN RATS, MICE, AND HAMSTERS AUTHOR/AFFILIATION DREW RT,NATIONAL INSTITUTE OF ENVIROMiENTAL HEALTH SCIENCESjBOORMAN 6A, SAMElHASEMAN JKSAME)MC CONNELL EE,SAME)BUSEY W1,SAME)M00RE JA, SAME) ORIGIN DATE ABSTRACT TOXICOLOGY AND APPLIED PHARMACOLOGY, VOL 68 NO 1 PP.120-X30) 1983, MARCH 30 AT THE END OF THE STUDY THE INCIDENCE OF VC-INDUCED NEOPLASMS HAS COMPARED IN EACH OF THE GROUPS TO ASSESS THE EFFECTS OF DURATION OF EXPOSURE AND AGE AT THE START OF EXPOSURE ON CARCINOGENICITY OF VC. IN RATS, WITH EARLY INITIAL EXPOSURE, HEMANGIOSARCOMAS, HEPATOCELLULAR CARCINOMAS, AND MAMMARY GLAND CARCINOMAS OCCURRED HITH INCREASING INCIDENCE WITH LONGER EXPOSURE DURATION. RATS HELD FOR 6 MONTHS BEFORE EXPOSURE DEVELOPED VC-RELATED NEOPLASMS, HHILE RATS HELD 12 MONTHS BEFORE THE START OF EXPOSURE FAILED TO SHOW A SIGNIFICANTLY INCREASED INCIDENCE OF THESE NEOPLASMS. IN HAMSTERS HEMANGIOSARCOMAS, MAMMARY GLAND CARCINOMAS,GASTRIC ADENOCARCINOMAS, AND SKIN CARCINOMAS RESULTED FROM VC EXPOSURE. THE HIGHEST INCIDENCE OF MALIGNANT NEOPLASMS OCCURRED IN HAMSTERS EXPOSED FOR THE FIRST 12 MONTHS, WHEREAS EXPOSURE BEGUN AFTER 12 MONTHS OF AGE DID NOT CAUSE NEOPLASMS. IN BOTH STRAINS OF MICE, VC EXPOSURE DURING THE FIRST 6 MONTHS OF THE EXPERIMENT INDUCED A HIGH INCIDENCE OF HEMANGIOSARCOMAS AND MAMMARY 6LAN0 CARCINOMAS. SWISS MICE ALSO DEVELOPED LUNG CARCINOMAS AFTER ONLY 6 MONTHS OF EXPOSURE. IN ALL THREE RODENT SPECIES AN INITIAL 12 MONTH EXPOSURE TO VC WAS ADEQUATE TO DETECT ITS CARCINOGENIC POTENTIAL, BUT THE SHORTENED SURVIVAL OF VC EXPOSED MICE AND HAMSTERS PRECLUDED A MEANINGFUL COMPARISON WITH LONGER PERIODS OF EXPOSURE. EXPOSURES WERE MOST EFFECTIVE WHEN STARTED EARLY IN LIFE. DESCRIPTORS xxxxxxx AGE) VINYL CHLORIDE)HAMSTERS)HICE)RATS)NEOPLASMS)HEMANGIOSARCOMA) MAMiARY GLAND)TUMQR) ADENOCARCINOMA)STOMACH>SKIN) LUNG(FIBROADENOMA)LIVER) Item 373 ACCESSION NUMBER 59 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN EVALUATION OF THE ASSOCIATION BETWEEN BIRTH DEFECTS AND EXPOSURE TO AfBIEWT VINYL CHLORIDE THERIAULT G, LAVAL UNZV)I7URRA H,SAME)GINGRAS S,SAME) TERATOLOGY,VOL 27 PP.359-370) DATE 1983, CIRCA ABSTRACT BIRTH DEFECTS INCIDENCE FOR INFANTS BORN TO RESIDENTS OF SHAHINIGAN,CANADA IN 1966-1979 HERE SIGNIFICANTLY HIGHER THAN IN THREE COMPARISON C0W1UNITIES. SINCE THERE HAS BEEN A VINYL CHLORIDE POLYMERIZATION PLANT IN THIS TOWN SINCE 1943 FROM WHICH TEN CASES OF ANGIOSARCOMA OF THE LIVER HAVE BEEN IDENTIFIED, THIS STUDY EXPLORES THE POSSIBLE ASSOCIATION BETWEEN EXPOSURE TO VINYL CHLORIDE MONOMER (VCM) IN AFBIENT AIR ANO THE OCCURRENCE OF BIRTH DEFECTS IN THE COftiUNITY. DESCRIPTORS xxxxxxx BIRTH DEFECTS)VCM)ANGIOSARCOMA)LIVER)POLyMERIZATION) HYPOSPADIAS)CATARACT)D0H4S SYNDROME) EPILEPSY>MENTAL DISORDERS) PSYCHOSIS)RUBELLA)PREGNANCY)CNS)SHAHINIGAN)