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CHEMICAL HYGIENE FELLOWSHIP KEY TO TOXICITY TESTS
mber
Name
1---------------- Peroral, single dose to standard rats 2-- --------------Peroral, single dose to other animals 3-- ---- Oral, subacute (usually 90 days or less) 4 ---------Oral, chronic (lifetime or 2 years) 5 ------------ --Parenteral (subcutaneous, incraperitoneal, intravenous, etc.) 6 ------------ --Skin Penetration, rabbits (24-hour contact under impervious sheeting) 7 ----------------- Skin Penetration, rats (4-hour contact under impervious sheeting) 8-- ----Skin Penetration, subacute (usually less than 90 days), 1 hour contact,
5 days per week 9- -------Skin Absorption (quantitative using tagged compounds) 10-------Inhalation, single--saturated vapor at room temperature, 20 to 23*C 11------------------- Inhalation, single--mist (at 170C or selected temperature) 12-----------Inhalation, single--fog (aerosol of 1 to 2 micron particle size) 13 --------- --Inhalation, single--measured concentration (ppm or mg/liter) 14 ---- -------- Inhalation, subacute (usually 90 days or less, 6 or 7 hours per day,
5 days per week 15 ----------------Metabolism, animal in viva and in vitro on either biopsy or surgical
specimens 16 --------------- DOT Corrosive, 4-hr 17 -------- -.--Rabbit Belly, irritation (single application, uncovered) 18 -------------Rabbit Belly, irritation (4-hour, eight applications)
19--------------Rabbit Belly,' irritation via repeated application (3x daily for up to 3 days)
20-------------------Rabbit Eyelid, irritation, to classify bland materials 21-- ------Rabbit Cornea, volume and concentration to produce injury 22-- ------------Rabbit Cornea, injury from vapor 23-- -----Mouse Skin Painting, for carcinogenicity 24----- -----------Rabbit Ear, chloracne formation 25-- --------Guinea Pig, Landsceiner (sensitization via intradermal or topical appli
cation) 26-- ------Human Patch Test (sensitization) 27-- ------Organoleptic Tests 28-- ------Wear Test (FDA) , miscellaneous irritation and wound healing 29-- ------Bacteriology, miscellaneous biochemical tests 30 ------- --3-Generacion Reproduction and Lactation 31 ------ ------Teratology 32-- --Mutagenicity 33-- ----Demyelina tion 34------- --------- Cholinesterase and/or ocher Enzyme Studies 35- --------------Joint Action, to detect potentiation or antidotal response 36-------------- --Literature Reviews 37 ----------------Endotracheal Injection 38 -------- ------ Pyrolysis (identification and toxicity studies)
January, 1976
'*
Chemical Hygiene Fellowship Carnegie-Mellon Institute of Research Carnegie-Mellon University
4400 Fifth Avenue Pittsburgh, Pennsylvania 13213
UCC 089031
UCC 089032
" Vinyl Resin . (Emulsion polymerized acetate)
Single Oral Dose to rats 50 ml./kg. of emulsion killed 0/6
Sensitization of Human Skin, Patch Test (Monthly Rpt, 2-29-44) Water dispersion dried on gauze applied to 32 subjects gave no sensitizations
9-30-53
3959
(Replaces B-S3
I
Vinyl Resins
Card 1
Vinyl Resins
Sensitization of Human Skin. Patch Test
Sheeted from Solvent
Resin
Sublects
Sensitizations
Hi--
gm VMCH VICN V1HH VINC VYNS reg'l
33 33 33 33 33
54
6? trace
3? trace 10? trace
6? definite 9? trace 10? trace
VINO VYNW
33 0? trace 53 8? trace
card 2
Renort
Aonlied as Powder Subiects Sensitizations Peno'
(1)
(1) 23 0 (2. (1) 23 0 (2. (1)
(1) 11 0 O' (1) 10 0 (3,
(1)
(1)
19
5? trace
(3;
(1) Monthly Rpt. 2-29-44; (2) Monthly Rpt. 12-31-43; (3) No report 1940, 1941
9-30-53
396o (Replaces B-33I
Vinyl Resins
UCC 089033
Vinyl Resins (Chloracne)
(Spec. Rpt., 10-129; 1947)
i'-fKA and VYRW alike 5% in Olive oil on 2 ears, 27 response in Stage I, under oil in II and III
5-30-53
3955 (Replaces B-1252)
nr'7 -w >1
mgr
inyl Resins
Vinyl Resin QINA Polyvinyl chloride
Toxicity of pyrblysia products (Rpt. 17-100; 1954)
A. Equal hasmrd to life can be expected from dispersion in an equal volume of
air of products of complete pyrolysis of the following weights of resins>-
Fluorothene FITS
l gram
* FITS
2 grams
Teflon (polytetrafluoroethylene)
8 grams
Polyvinyl chloride QINA
128 grams
B. Vapors lethal when inhaled for several hours will result from heating in air
a sufficient amount of resin to the following temperature:-
QXHA
265C.
FITH, ms 310C.
435C.
9-15-54
4278
El
11
Vinyl Resin QZHA
UCC 089034