Document DDVGXrnVnpqmKeLkg0Nn6B1Y4

& CHEMICAL MANUFACTURERS ASSOCIATION May 23,1995 Dear Vinyl Chloride Health Committee Members: The May 4,1995, response from the Agency for Toxic Substances and Disease Registry to our March 22 letter is enclosed. The response is favorable to the industry. Jonathan Ramlow, Bill Breslin (Dow), Caffey Norman and I talked to ATSDR representatives on May 16 to discuss the industry approach on the combined reproductive and developmental effects study protocol. The industry approach was acceptable to ATSDR. The Record of Conference Call is enclosed. Bill Breslin will prepare a draft protocol for the Committee's review prior to submission to ATSDR. The Agency has requested the final protocol by June 9. I anticipate distributing the draft protocol by June 2. Jonathan Ramlow has asked me to explore the feasibility of scheduling a Committee meeting on June 7 or 8. There are many issues that need to be discussed as soon as possible. The most important among them is review of the combined 2generation reproductive and developmental effects study protocol. The agenda for the meeting is enclosed. The Pesticide and Toxic Chemical News report on EPA's vinyl chloride cancer risk assessment presented at the Conference on Risk Assessment for Sensitive Populations is enclosed. I will try to get more information from Jim Cogliano of EPA on his presentation prior to our next meeting. I received the enclosed Cancer Facts & Figures -1995 from Ed Beeler. The 1994 edition associated vinyl chloride exposure with lymphoma. The Committee filed comments with the American Cancer Society last year objecting to this association in the absence of scientific data to link vinyl chloride exposure to lymphoma. The ACS agreed with our comments and deleted reference to vinyl chloride from the lymphoma section in its 1995 edition. Please complete the enclosed availability survey and return it to me by fax at (202) 887-5427 AS SOON AS POSSIBLE so that a meeting can be arranged. If you have any questions, please call me at (202) 887-1192. Sincerely, Enclosures SfttO --------- ' Hasmukh C. Shah, Ph.D. Manager, Vinyl Chloride Panel r &S145005 2501 M Street, NW, Washington, DC 20037 Telephone 202-887-1100 Fax 202-887-1237 Responsible Care* 1 [ APublicCommitment