Document DDQdGKoZ2MR8gjXELe0BvqqRN

PUBLIC HEALTH SERVICE * BETHESDA, MD. 20014 NATIONAL INSTITUTES OF HEALTH Area Code 301 Tel: 656-4000 September 8, 1965 Dr. Robert A. Kehoe University of Cincinnati The Kettering Laboratory College of Medicine Eden Avenue Cincinnati 19, Ohio Dear Dr. Kehoe: Thank you for your recent letter regarding our paper in Science 148: 1547, 1965, and our footnote #27 concerning tetraethyl lead. I hasten to admit that it was an error. The error crept into one of the drafts and for some reason (perhaps because it was a foot note), none of the authors caught it. Actually,a comedy of errors took place. An early copy stated that naphthylamine and tetraethyl tin were examples of substances that are converted in the body to more toxic substances, tetraethyl tin being converted to triethyl tin and naphthylamine to l-'nydroxylnaphthylamine, a carcinogenic agent. Somehow, the tetraethyl tin became tetraethyl lead and both it and naphthylamine became con verted to carcinogenic agents. We apologize for the error and hope that it did not cause you any undue inconvenience. Sincerely yours. (ft Bernard B. Brodie, Ph.D. Chief, Laboratory of Chemical Pharmacology National Heart Institute 0019974