Document DDJRE2dxq318zoRG84NzKKO4d

oo Ur, T.S. Foloy - New York Mr. Paul Iogue - St. Louis Dr. R.L. Jenkins - Anniston Usosre. Edgar K. Hardy J,T. Peeves (2) A.11. Pliant R.P. Loewen Deeenbor SO, 194? Celeneae Corporation of America Central Reeearoh Laboratory Dunrnlt, Now Jersey Ocntlenieni Dr. L. s. Blr&baua As suggested by Dr, R. L. Jen\lna in his letter to you on December 23, wo ere pleaoed to mrito ebout Aroclor toxlolty considerations. The boat published information bbout the toxicity of Aroclor vapors with roferenee to possible damage to the liver is in a series of three articles written for tho Journal of Iaduetrioj Hygiene and Toxloology., The first artlolo appacirlng in the September^ 937'isoue,--* Vol. 19, No, 7 and the aeeond article publlohed is the Pebruary 1938 issue, Vol, 20, No, 2 were written by C^K, Drinker, M, T. *?arren, sad 0. A. Bonnet and cover only Aroclor 4465. The third artiole written by Dr. Drinkor slone is nore complete oe it give* information about Aroolors 4455, 1254, 1260 end 5460, -e particularly wish to refer you to this artiole entitled, "further Obaervetlons on the Possible Dyotenic Toxicity of Certain of tl*> Chlorinated Hydrocarbons with suggestions for Permissible Concentration* In the Air of Vorkrooms*, .by Ceoll K. Drinker,.The Journel of Industrial Hygiene eDd Toxicology, Vol. 1, No. 5, Kay, T5357 '^ In this artlelo Dr. Drinker tabulates the permissible limits of tho oompounds in mg. per cubic meter of air In workrooms. The .following date is as. exesrpt pertaining to para 1 risible limits of various Aroclor si Material . Peraiecible Limit Mg, per Cu. U, No. 6 No. 9 . Ho. is' No. 14 Aroclor 4465 Aroclor 1254 Aroolor 1268 Aroolor 6460 ' 0.8 0.8 10.0 0.5 - . from this. It is noted that there lo o mrkod variation la ths toxicity of the vapors of Aiffarsst Aroolors. To quota Dr. Drinker, "Aroclor 1268 is almost non-ioxie". TJu voporc of the other Aroelor studied ere toxio and should be avoided. In "cueml, the more highly ehlorireted biphenyls are less toxic than tho lower chlorinated deriyetiveo, proba- w,, EXhUBIT fU. /Jo. TRAN 016789 WATER PCB-SD0000001026 *\ tt o bly flu to decreoeed solubility, Tho chlorinated torpbenyle appear to be acre toxio then correponding oulorlnated biphenyl#, iThero the oold or solvent method is used for tho impregnation of Aroclore usually only normal prectutione or ordinary cleonllnesa of commercial plant praotioo nr followed.' Vhen tho Aroclors ere v. uppliod by hot methods, 300* T. or hlr,hor, the workrooms should be voatilotod by Intake end exhaust fane of cufficient volume end volocity to reaove t.he majority of tho fun#. Whore ever drying even# are used, the tupore rust bo romoved. Suggestions obout this are given in the ertiole entitled, ''Observations on the Torle Effects Resulting froja Exposure to Chlnrtnntod Kophthlene and Chlorinated Phenyl witb Suggestions for Provenilon", by Dr. H, Von Eodel, Dr. Si. A. Holla end Dr. James Denton, publlohod in Tho Rubber Are. Vol, 33, Mo, 5, August 1943. - . In eoneral, it is believod thot Uo auxlmre permissible amount of Aroolor vapor in the workroom ie evident to the workmen boesuso of an irritating influence on the eye meabrone*. Zt therefore beoomas a self-revealing elcnnl when dftngcroue level# are reeohod. If you desire, we will be glfJd to Xrnd you an lnetrument which wo have with full instructions for Its operation to ooasur# Aroclor vapors in your workroom atmospheres. Thin would be the most cortein mothod to deteraine that your working conditions are safe. In your letter of Doeembor 19 to Dr, Jenkins, you asked whether studio# have been node of tho ponr.ible toxicity or dermotitld dtic to finished manufactured items contoInins Aroclore as an ingredient. It was determined by the skin patch test procedure given by Dr. Louie Sohvmrtx and Dr. Samuel M. Dock lr. reprint No. 8553 from the Public . Health Report*, Vol, 59, llo. 17 (April ZB, 1944) that canvec painted with Aroclor 5460 and an oil modified nlVyd resin in such a runner thot each square ineb of fi.brle eontclnod 10.5 c. of Aroclor 5460, we a neither a eldn irritant. :: >r :tv cltir.cr. Tt following ooamorcial ap;>lI cations oro soao typlenl large current outlet* for Aroclore and to our knovlcdee, there 1# no Into roc of . difficulty about toxicity even V.:>i;h in a number of they* applications elevated temperatures are uood and consumers ooae in rather lose ' eofltoat with the finished commodity contelnlng Aroolor. * 016790 1. Actuating fluid for t.Vr fio.otets, . '/ 2. Beat transfer medium. 3. Non-flcrwoblo hyAi.lle fluid, especially . . ' for die easting *vchincs. ' 4. Adhesives for rmoy -'lr-r.-or.; . .1 . 5. Vood preservative and sealer treetasnte. 6. Air compressor lubricant. .. 7. Plasticiser for nitrocellulose, ethyl eelluloee , and polyvinylchloride coatings. (In a number of . applieetlone of ti'ln typo the container ones in WATER PCB-SD0000001027 oo s- intimate contact with t)t coatinr compositions. A good example is coated heolo of ladle#* shoe#). 6. riastloiner for J'urlon end Pliolite points ana costings. 9. Plasticizer for wlro lnouletlnc compounds. 10. In trenoformor# end capacitors. . 11. A a as impr'.7ont for paper products. 12. Preosure eensltlve sealers. 13. Id fire retardant points and coatings. . 14. Inprecnent for textiles. 10. Industrial printing inks. 10. Stop-off looquera for electroplating. 17. Cernmlo, glaze printing.. . 18. Plactielzer for usobult compositions. 19. In the manufacture of donturee. , EnDed on our practical experience in the manufacture end #ale of ' millions of pound# of Aroclors annually, the point that re would onpbuaize is that workers should not be expooed to Aroelor vapor* and that the ten working with Aroclors should observe "good house keeping" rulea about keeping tholr clothing and skins free of the material and avoid Ingestion of it. Adequate ventilation bn# proved wiocoooful In keeping the etmoephere free from harmful amounts of Aroclors around machinery and in plants. '/Then you hove had opportunity to rive eonelderatton to our above comments, pieces let us hare your thoughts end let ue know if we can be of further aseietanoo to you. . Yours very truly P. 0. Ponifpus Dovolopncat Department TRAN 016791 WATER PCB-SD0000001028