Document DD3dGpEOJdjNZ1J45Lw58K5wN

bcc; D. R. Pogue - LOS ANGELES April 25, 1968 Miss Elnor Perry, R. N. McCulloch Corporation 6101 West Century Blvd. Los Angeles, California 90045 Dear Miss Perry: Mr. Pogue, of our Los Angeles Office, has asked m to forward toxicity and safe handling information relative to our fireresistant hydraulic fluid, Pydraul 312. The oral toxicity of Pydraul 312 shows an LD*q to rats of 6500 mg/kg and it is classified as "practically non-toxic" from the acuta oral point of view. When applied to the skin undiluted and allowed to remain over night, a barely perceptible redness occurred, giving a maximum score of 1.3/8.0, which was classed as a slight irritant. The material proved capable of being absorbed through the skin in high doses when allowed to remain on the rabbit under a cuff. The minimum lethal dose was somewhere over 2000 and under 3000 mg/kg. This would fall into the "slightly toxio" range. The material is a slight eye irritant when applied undiluted to the tabuita' eyes and there was mild discomfort and slight redness. The maximum score was 13/110 and the eye had returned to normal within three days. Rats survived six-hour inhalation exposure to the vapors evolved at ambient temperatures following the passage of air through the material. No systemic effects were noted. We conclude from the above that accidental ingestion on the part of humans is not a particular hasard in view of the high oral lethal dose in rate. Similarly, single massive skin exposures should not be immediately hasardous. The lethal dose obtained in skin penetration studies is such, however, that prolonged and repeated skin contact should be avoided because of possible systemic effects. In addition, prolonged and repeated skin con tact may lead to skin irritation. DSW 018625 STLCOPCB4005169 Mia# Elnor Parry -2- April 25, 1968 We also feel that vapor inhalation should be avoided when the fluid is heated to elevated temperatures. Such exposure again relates to prolonged or repeated exposures rather than short-term massive or acute exposures. In the case of the latter, workmen would not voluntarily expose themselves to concentrations that are haxardous because of irritation of the respiratory tract. I have enclosed a copy of a summary of our interpretation of the data for Pydraul 312. If X can be of any further help, please let me know. Sincerely, MNJ/ln enc. M. N. Johnson, M. D. Assistant Medical Director OSW 018626 STLCOPCB4005170