Document D1nxeGvwqDE8OB7xeevOkDXQ

PENGAO-Baywine.N.J, CONFERENCE on BIOLOGICAL EFFECTS OF ASBESTOS Monday, October 19, Tuesday, October 20, and Wednesday, Ocfo&er 21, 1964 /. f THE NEW YORK ACADEMY OF SCIENCES SECTION OF BIOLOGICAL AND MEDICAL SCIENCES 2 East Sixty-third Street New York, N. Y. 10021 The evening session on October 20 wit! be held at the'Academy Building ALL OTHER SESS/O/VS H7LL BE HELD AT The Waldorf-Astoria Park Avenue at 50th Street New York, N. Y. Thl program will m m ticket ot mnd I# intfmnatwrmbtm. sncuooo? Preface of the Conference In the four decades during which there has been acceptance of potential hazards associated with exposure to asbestos, solutions to the problems involved have been elusive, Therapyof asbestosis remains largely a rearguard holding action once the diffuse interstitial fibrosis is established. Prophylactic measures are hampered by difficulties In early diagnosis, including the long latent period often noted between onset of exposure and clinical change. Hard won data have been accumulating which indicate that neo plasia associated with asbestos exposure, especially those of the lung, are perhaps the most important industrial cancers at this time. This importance has been emphasized by the recent stimulating studies of South African and British investigators demonstrating the significant incidence of pleural and peritoneal tumors associated with asbestos exposure and by the knowledge that the various neo plasms might follow exposure of limited duration and intensity, in adequate to result in significant asbestosis. There have been effective advances in dust control techniques, accomplished by diligent, ingenious and expensive engineering. However, application of these procedures has been hampered by the rapid growth of asbestos utilization, sometimes under circum stances in which exposure has been obscure or unrecognized. More over, community and indirect occupational exposure may occur; the scope and importance of such "asbestos air pollution" are at pre sent uncertain but their potential significance has attracted atten tion. The foregoing sober inventory provided the stimulus and back ground for this Conference. The Scientific Council of the Academy considered that the interdisciplinary nature of the problem, involving such distinct fields as experimental pathology, applied physiology, oncology, epidemiology, and industrial hygiene could best be served by a broad conference of investigators in the biological sciences and those In allied fields. , In October 1963 visits were made by Dr. Selikoff on behalf of the Academy to several European centers to investigate the feasibility and potential scope of such a conference. In particular, British studies were reviewed with Dr. J.C. Gilson, Director of the Medical Research Council Pneumoconiosis Research Unit. The cooperation of Dt. 11. Heimann of the Division of Occupational Health of the United Stat.es Public Health Service facilitated a survey of current work tn this country. "Sequelae of Asbestos Dust Exposure" -- J, C* Wagner, M.R.C. Pneumoconiosis Research Unit, Glamorgan, Wales. "Changing Hazards of Asbestos Dust Expsute**.-- J. C. Gilson, M.R.C. Pneumoconolosis Research Unit, Glamorgan, Wales. "Multiple Factors in Relation td Neoplasia Among Asbestos Workers** 1 * Vofk. N. Y. , PANEL DISCUSSION Moderator: H. `Heimann Division of Occupational Health U, S. Pubfic Health Service Washington, D. C. The Section of Biological and Medical Sciences provides con ferences for activ^ workers in the special fields of biology and medicine. ' This conference may be attended by interested Members of the - ~i...OTi^sann research scientists, and science and med- SECTION OF BIOLOGICAL AND MEDICAL SCIENCES Preston L. Perlman Chairman Gabriel G. Nahas Vice-Chairman , li t 50040001 ( WEDNESDAY, OCTOBER 21, 1964 Session Chairman: H. L. Stewart National Cancer Institute, Bethesda, Md. 9:00 A.M. - "Epidemiology of Diffuse Mesothelial Tumors: Evidence of an As- sociatipn from Studies in South Africa and the United Kingdom" - J. C. Wagnefl, M.R.C. Pneumoconiosis Research Unit, Glamorgan, Wales. ^ "Epidemiological Studies of Patients with Mesothelial Tumors in the London Area" -- Muriel L. Newhouse, School of Hygiene and Tropical Medicine, University of London, London, England. } 1 ;1 DIFFUSE MESOTHELIAL TUMORS PANEL DISCUSSION MODERATOR: W. U. Gardner, Yale University School of Medicine, New Haven, Conn. [ "Criteria for Diagnosis of Diffuse Mesothelial Tumors" -- W. T. E. McCaughey, Queen's University, Belfast, Northern Ireland. "Histological Chacteristics of Mesothelioma Associated with Asbestos" -- J. Churg, The Mount Sinai Hospital, New York, N. Y., S. Moolten, Middlesex General Hospital, New Brunswick, N. J., and S. Rosen, Armed Forces Institute of Pathology, Wash ington, D. C, "Mesothelial Tumors in South Africa: Pathology and Experi mental Pathology" -- 1. Webster, Pneumoconiosis Research Unit, Johannesburg, South Africa. "A Biopsy Series of Mesotheliomata and Attempts to Identify Asbestos within Some of the Tumours" -- D. O/B. Hourihane, London Hospital Medical School, London, England. "Pleural Mesothelial Tumors and Exposure to Asbestos Dust"-- W. Glynn Owen, Broadgreen Hospital, Liverpool, England. Discussion opened by A. Purdy Stout, Columbia University College of Physicians and Surgeons, New York, N. Y. 12:30 P.M. Luncheon Session Chairman: E. C. Vigliani University of Milan, Milan, Italy . , ^ PROBLEMS AND PERSPECTIVES 2:00 P.M. "Trends in the Health of the Asbestos Worker" - K. W. Smith, JohnsManville Corporation Manville, N. j. The Academy was fortunate in securing the advice of a Con ference Committee which encompassed the major areas involved. Its members, themselves actively concerned with the problem, met January 6, 1964 in New York. The preliminary design of a meeting then formulated was refined during the succeeding months by thp Committee with the assistance of active investigators in many parts of (he world and by July, 1964 the Conference program was com pleted. It is thp hope of the Academy that this Conference will be u fertile one and will lead to decisive findings on this important problem. July 17, 1964 Eunice Thomas Miner Executive Director The New York Academy of Sciences} ./ ORGANIZING COMMITTEE Irving J. Sellkoff Jacob Churg, W. Clark Cooper John C. Gilson E. Cuyler Hammond Thomas F. Mancuso E. Lynn Schall William E. Smith Cochairman; The Mount Sinai Hospital, fiew York, N. Y. Cochairman; The Mount Sinai Hospital, New York, N. Y. School of Public Health, University of Calif ornia, Berkeley, Calif. Pneumoconiosis Research Unit, Medical Re search Council, Penarth, Glamorgan, Wales American Cancer Society, New York, N. Y. Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pa. Occupational Health Program, New Jersey State Department of Health, Trenton, N. }. Health Research Institute, Fairleigh Dickin son University, Madison, N. J. 500^0003 Conference Cochairmen: I. J. Selikoff and J. Cburg The Mount Sinai Hospital New York, N. Y. PROGRAM , MONDAY, OCTOBER 19, 1964 Session Chairman: H. J, Magnuson Institute of Industrial Health, University of Michigan Ann Arbor, Mich. 9:00 A.M. Greetings from the Academy -- Gabriel G. Nahas, Vice-Chairman, Sectionof Biological and Medical Sciences, The New York Academy of Sciences; College of Physicians and Surgeons, Columbia Uni versity, New York, N. Y. Opening Remarks -- I. j. Selikoff, The Mount Sinai Hospital, New York, N. Y. ASBESTOS MATERIALS IN MODERN TECHNOLOGY . Session Cochairman: P. H. Riordon Asbestos Corporation Limited Thetford Mines, Quebec "The Geology, Occurrences and Major Uses of Asbestos" -- N. W. Hendry, Canadian Johns-Manville, Ltd., Asbestos, Quebec. "Physical and Molecular Structure of Asbestos" -- R. Gaze, The Cape Asbestos Company, Ltd. (Asbestosis Research Council), London, England. LIVING TISSUE AND MINERAL MATTER: PROBLEMS OF PATHOGENESIS Session Cochairman: I. Webster Pneumoconiosis Research Unit Johannesburg, South Africa PROBLEMS OF IDENTIFICATION OF ASBESTOS IN HUMAN TISSUE: PANEL DISCUSSION MODERATOR: P.Gross, Industrial Hygiene Foundation, Pittsburgh, Pa. in the Respiratory Tract" -- Llonas Miller and W. E. Smith, Fairlei gh Dickinson University, Madison, N. J. Discussion opened by j. C. Wagner, M.R.C. Pneumoconiosis Re search Unit, Glamorgan, Wales. Asbestos and neoplasia-, epidemiology Session Cochairman: W. J. Smither The Cape Asbestos Company, Ltd. . ` London, England "Asbestosis and Bronchial Carcinoma" -- T. A. Lloyd Davies and W. D. Buchanan, Ministry of Labour, London, England. "Neoplasia Among Insulation Workers in the Uniterlj, States with Special Reference to Intra-abdominal Neoplasia" -- E. C. Hammond, I. J. Selikoff, and J..Churg, The Mount Sinai Hospital*, New York, N-Y- ' f "CohortAnalysis of Changes in Incidence of Bronchial Carcinoma in a Textile Asbestos Factory"--J. F. Knox, (Asbestosis Research Council), Turner Brothers Asbestos Company, Ltd., Rochdale, and R. S. Doll, M. R. C. Statistical Research Unit, London, England. "Pulmonary Neoplasia Among Dresden Asbestos Workers" -- G. Jacob, Krankenhaus, Karl Marx Stadt, and M. Amspech, Institute of Occupational Health, Dresden, G.d.R. ' "The Relationship of Exposure to Asbestos to Pleural Malignancy in Belfast" -- P. C. Elmes and O. L. Wade, Queen's University, Belfast, Northern Ireland. "Association of Pulmonary Neoplasms with Asbestos Exposure in Northern Italy" -- E. C. Vigliani, University of Milan, G. Mottura, University of Turin, and P. Maranzana, National Institute of Oc cupational Diseases, Lombardy, Italy. Disscussion opened by T. Mancuso, University of Pittsburgh, Pitts burgh, Pa., and G W. 11. Schepers, institute of Industrial and Fo rensic Medicine, Washington, D. C. 6:00 P.M. - Cocktail Hour - Academy Building, 2 East Sixty-third Street, New York, N. Y. 7:00 P.M. - Informal Subscription Dinner -- Academy Building Keynote Address: J. C. Gilson, Medical Research Council, Pneumoconiosis Research Unit, Glamorgan, Wales. ,* 5(i()40O^4 PULMONARY FUNCTION IN ASBESTOSIS PANEL DISCUSSION MODERATOR: G. L. Leathart, University of Newcastle, Newcastle, England. ,, "Pulmonary Function in Asbestosis: Serial Tests in Long Term Prospective Study" .-M. Bader, R. Bader and A., Tierstein, The Mount Sinai Hospital, New York, N.*Y. "Routine Lung Function Studies of 830 Employees in an As* bestos Processing Factory" -- R. Hunt, (Asbestosis Research Council), British. Belting and Asbestos, Ltd., Yorkshire, Eng land. *' '! - "The Discriminant Value of Pulmonary Function Tests in As- bestosis" -- M. L. Thomson, W. J. Smither, Anne-Marie Pelzer and M Hjiils, London School of Hygiene and Tropical Medicine, University of London, London, and The Cape Asbestos Com pany, Barking, Essex, England. . Discussion opened by J. L. Whittenberger, School of Public Health, Harvard University Boston, Mass. 12:30 P.M. - Luncheon Session Chairmen: W. C. Cooper School of Public Health, University of California Berkeley, Calif. ASBESTOS AND NEOPLASIA: EXPERIMENTAL Session Cochairman: Katherine R. Boucot Woman's Medical College of Pennsylvania Philadelphia, Pe. 2:00 P.M, "Studies of Carcinogenesis of Asbestos Fibers and Their Natural Oils" -- J. S. Harington end F. J. C. Roe, Chester Beatty Research Institute, Royal Cancer Hospital, London, England. "Preparation of Asbestos Fibers for Experimental Use" -- M. S. Badollet,Health Research Institute,Fairleigh Dickinson UDiversity, Madison, N. J, and W. A. Gantt, Occupational Health Program, N. J. State Department of Health, Trenton, N. J. "Tests for Carcinogenitity of Asbestos" -- W. E. Smith and Llonas Millet, Health Research Institute, Fairleigh Dickinson University* Madison, N. J. "Tests for Effect of Asbestos on Benzo (a) Pyrene Carcinogenesis "Identification by Fluorescent Dye Staining and Electronically Activated Oxygen Ashing" - C. Berkley and J. Churg, The Mount Sinai Hospital, New York, N. Y. "Identification of the Several Varieties of Asbestos Fibers in Human Lung Tissue" -- A. Vorwald, Wayne State University College of Medicine, Detroit, Mich. ' "Dust Content and Composition in Lungs with Asbestosis" G. Nagelschmidt, Safety in Mines Research Establishment, Sheffield, England. EXPERIMENTAL ASBESTOSIS PANEL DISCUSSION MODERATOR: J. C. Wagner, Medical Research Council Pneumo coniosis Research Unit, Glamorgan, Wales. < "Asbestos Dust Deposition and Retention in Animals" -- J. C. Wagner and J. W. Skidmore, M.R.C. Pneumoconiosis Research Unit, Glamorgan, Wales. ' "Experimental Asbestosis with Three Types of Fibers: Impor tance of Particle Size" -- J. Mills end P. F. Holt,(Asbestosis Research Council), University of Reading, Reading, England, "Electron Microscopic Studies of Asbestosis in Man and Ani mals" - J. M. G. Davjes, (Asbestosis Research Council),Uni versity of Cambridge, Cambridge, England. "Rheumatoid Factor in Serum of Individuals Exposed to Asbestos" -- 3. Pernis and E. C. Vigliani, University of Milan, Milan, Italy, and I. J. Selikoff, The Mount Sinai Hospital, New York, N. Y, "Observations on the Pathogenesis of Asbestosis" - E. C. Vig liani and B. Pernis, University of Milan, Milan, Italy. 12:30 P.M. Luncheon Session Chairman: J. H. Sterner Eastman Kodak Company Rochester, N. Y. HUMAN EXPOSURE TO ASBESTOS: ASBESTOSIS IN INDUSTRIAL POPULATIONS Session Cochnirrrnn: f. C. Gilson M.R.C. Pneumoconiosis Research Unit Glamorgan, Wales 2:00 P.M. - ' " Asbestosis in the United Kingdom" -- J. C. McVittie, Ministry of Pensions and National Insurance, London, England. 50040005 "Asbestosis Among Insulation Workers inthe United States** -^1, J. Selikoff, [. Churg, and E. C. Hammond, The Mount Sinai Hospital, New York, N. Y. "Mortality Rates Among Asbestos Products Workers in the United States" -- P. Enterline, U. S. Public Health Service, Washington, D. C. "Secular Changes in Asbestosls in an Asbestos Factory** -- W. j. Smither, (Asbestosls Research Council), The Cape Asbestos Com pany, Ltd., London, England. HUMAN EXPOSURE TO ASBESTOS: COMMUNITY STUDIES Session Cochairman: J. IHgginson University of Kansas School of Medicine Kansas City, Kan. "Occupational and Nonoccupational Exposure to Asbestos'* -- W. C. Hueper, National Cancer Institute, Bethesda, Md. } "Prevalence of Asbestos Bodies in Autopsy'Cases** -- J.C.Thom son, University of CapeTown, CapeTown, South Africa. "Asbestosls: Geographical and Environmental Studies in South Africa** -- G. K. Sluis Cremer, Pneumoconiosis Bureau, Johannes burg, South Africa "Pleural Plaques and Asbestos: Further Observations on Endemic and other Nonoccupational Asbestosis*' - R. Kiviluoto, Tampere Central Hospital, Tampere, Finland. Session Chairman: J. H. Wolfsie United States Rubber Company _________ New York, N. Y.______________ Session Coc/mirmnn: L. Cralley U.S.P.II.S. Occupational Health Research and Training Facility Cincinnati, Ohio 8:00 l\M. "Inhalation of Fibrous Dusts** -- V. Timbrell, M.R.C. Pneumo coniosis Research Unit, Glamorgan, Wales. "Comparison of Impinger and Membrane Filter Techniques for Eval uating Air Samples in Asbestos Plants** -- If. E. Ayer, Division of Occupational Health, U. S. Public Health Service, Washington, D. C. "Developments in Dust Sampling and Counting Techniques in the Asbestos Industry" -- S. Holmes, (Asbestosis Research Council), Turner Brothers Asbestos Company, Ltd. Rochdale, England. "Dust Measurements and Monitoring in the Asbestos Induslry"C. G. Addingley, (Asbestosis Research Council), British Belting and Asbestos, Ltd., Yorkshire, England. "Measurement of Airborn Asbestos Dust by Instruments Measuring Different Parameters** -- S. A. Roach, London School of Hygiene and Topical Medicine, University of London, London, England. Discussion opened by T. Hatch, University of Pittsburgh, Pitts burgh, Pa. ' TUESDAY, OCTOBER 20, 1964 iv Session Chairman: Harriet L. Hardy . Massachusetts Institute of Technology Cambridge, Mass. ; . DUST CONTROLS AND STANDARDS 9:00 A.M. - {j "Present Threshold Limit Value in the U. S. A. for Asbestos Dust: A Critique** - E. Li Scholl, Occupational Health Program, New Jersey Static Department of Health, Trenton, N. *J. "Economics of Dust Control** - D. W. Hills, (Asbestosis Research Council), Turner Brothers Asbestos Company, Ltd., Rochdale, Eng land. Session Cochairman: L. Silverman School of Public Health, Harvard University Boston, Mass. PULMONARY ASBESTOSIS "Radiological Classification of Pulmonary Asbestosis** -- H. Bohlig, Municipal Hospital, Lddensheid, Germany. "Roentgenological Studies of Pleural Calcification in Asbestosis** -- I. J. Selikoff, The Mount Sinai Hospital, New York, N. Y. "Differential Diagnosis in the Pathology of Asbestosis** -- j. Gough, Welsh National School of Medicine, Cardiff, Wales. "Roentgenological-Pathological Correlations in Pulmonary Asbes tosis in the United Kingdom and South Africa** -- K. F. W. Hinson, Brompton Hospital and J. C. McVjttie, Ministry of Pensions and National Insurance, London, England; G. K. Sluis Cremer and C. P. Theron, I ueumoconiosis Bureau, Johannesburg, South Africa. Disscussion opened by P. Cartier, Thetford Industrial Clifiic, Thetford Mines, Quebec, and I. Webster, Pneumoconiosis Research Unit, Johannesburg, South Africa. . .4 1 50040006