Document Bz8Lb14MEJr7EvY53nQr1qjk

Huntingdon STUDY NO. 96-4080 VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS Reproduction Study Unaudited Draft Final Report Volume II of III Submitted to: Chemical Manufacturers Association Chemstar Department 1300 Wilson Boulevard Arlington, Virginia 22209 Attn: Hasmukh C. Shah, Ph.D. Date: 5 May 1998 Page 1 BFG 002663 APPENDIX E BFG 002664 REPRODUCTION STUDY 96-4080B E-i APPENDIX E VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BOOT WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 19 OOSE LEVEL 0.0000 PPM MALES ANIMAL NO. 1031 1032 1033 1035 1037 1039 1041 1043 1045 1047 1048 1050 1052 1054 1056 1057 1058 1060 1061 1062 1063 WEIGHT G 172 77 157 144 122 136 75 147 137 68 60 123 144 133 138 132 109 160 157 137 123 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT BFG 002665 REPRODUCTION STUDY 96-40808 E-Z APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 19 DOSE LEVEL - 0.0000 PPM MALES ANIMAL NO. 1064 1066 1068 1070 1071 1072 1074 1076 1078 WEIGHT G 151 152 158 126 164 172 172 168 158 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT NO. OF ANIMALS 30 MEAN 135.7 STD. DEV. 31.0 bfg 002666 REPRODUCTION STUDY 96-4080B E-3 APPENDIX E (cent.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 19 DOSE LEVEL - 10.0000 PPM MALES ANIMAL NO. 2031 2033 2034 2036 2037 2038 2040 2042 2044 2046 2048 2050 2052 2054 2056 2058 2060 2062 2064 2066 2067 WEIGHT G 160 182 147 172 153 122 122 108 146 121 150 119 119 148 161 185 143 137 159 157 153 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT BFG 002667 REPRODUCTION STUDY 96-40808 E-4 APPENDIX (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK f: 19 OOSE LEVEL 10.0000 PPM MALES ANIMAL NO. 2068 2070 2072 2073 2074 2075 2076 2077 2078 WEIGHT G 157 145 134 142 139 148 154 172 171 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT NO. OF ANIMALS 30 MEAN 147.5 STD. DEV. 19.2 BFG 00266$ REPRODUCTION STUDY 96-40808 E-5 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BOOY WEIGHT AND FOOD CONSUMPTION PREHATING TREATMENT PERIOD - P2 GENERATION WEEK f: 19 DOSE LEVEL - 100.0000 PPM MALES ANIMAL NO. 3031 3032 3033 3034 3035 3037 3039 3041 3042 3043 3045 3046 3047 3048 3049 3050 3051 3052 3055 3057 3058 HEIGHT G 164 183 96 87 102 157 121 65 65 163 149 140 172 195 113 110 148 149 168 121 124 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT BFG 002669 REPRODUCTION STUDY 96-40B08 E-6 APPENDIX E (cont.) VINYL CHLORIDE C0M6INE0 INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND POOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 19 DOSE LEVEL - 100.0000 PPM MALES ANIMAL NO. 3059 3061 3063 3064 3065 3066 3067 3069 3070 WEIGHT G 166 146 191 164 159 156 146 160 151 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT NO. OF ANIMALS 30 MEAN 141.8 STD. DEV. 34.6 j$FG 002670 REPRODUCTION STUDY 96-4080B E-7 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT MO FOOD CONSUMPTION PREHATING TREATMENT PERIOD - P2 GENERATION WEEK f: 19 OOSE LEVEL - 1100.0000 PPM HALES ANIMAL NO. 4031 4033 4035 4037 4039 4041 4043 4045 4046 4047 4049 4050 4052 4054 4056 4058 4060 4062 4064 4066 4066 WEIGHT G 169 152 135 165 164 147 126 138 139 159 90 134 171 117 141 120 123 111 167 136 163 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT BFG 002671 REPRODUCTION STUDY 96*40808 E-8 APPENDIX E (cont.J VINYL CHLORIDE COTOINEO INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT ANO FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 19 OOSE LEVEL - 1100.0000 PPM MALES ANIMAL NO. 4070 4071 4072 4073 4074 4076 4077 4079 4081 WEIGHT G 150 148 174 169 159 105 133 107 119 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT NO. OF ANIMALS 30 MEAN 141.0 STO. DEV. 22.7 BFG 002672 REPRODUCTION STUDY 96-4060B E-9 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 19 DOSE LEVEL 0.0000 PPM FEMALES ANIMAL NO. 1531 1533 1535 1537 1538 1539 1540 1541 1542 1543 1545 1547 1549 1561 1553 1555 1557 1558 1559 1561 1563 WEIGHT G 132 75 129 128 118 127 95 126 135 137 105 66 61 140 138 120 117 115 121 107 124 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT BFG 002673 REPRODUCTION STUDY 96-4080B E--10 APPENOIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT ANO FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 19 DOSE LEVEL - 0.0000 PPM FEMALES ANIMAL NO. 1S65 1566 1568 1570 1572 1574 1576 1576 1560 WEIGHT G 120 140 120 137 126 122 134 129 120 NO. OF ANIMALS 30 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT MEAN 11B.6 STD. DEV. 20.4 BFG 002674 REPRODUCTION STUDY 96-40806 E-ll APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOO - P2 GENERATION WEEK #: 19 DOSE LEVEL - 10.0000 PPM FEMALES ANIMAL NO. 2532 2533 2534 2536 2538 2540 2541 2543 2544 2546 2548 2550 2552 2553 2554 2555 2556 2557 2558 2559 2561 WEIGHT G 136 134 148 125 137 110 132 101 133 119 129 97 12S 134 133 140 140 163 161 141 110 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT BFG 002675 REPRODUCTION STUDY 96-4080B E-12 APPENDIX E (cont.) VINYL CHLORIDE COMBINEO INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOO - P2 GENERATION WEEK #: 19 DOSE LEVEL - 10.0000 PPM FEMALES ANIMAL NO. 2563 2566 2567 2569 2571 2573 2575 2577 WEIGHT G 122 138 131 124 120 109 137 122 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT NO. OF ANIMALS 29 MEAN 129.3 STD. DEV. 15.3 BFG 002676 REPRODUCTION STUDY 96-4080B E-13 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND POOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK i: 19 DOSE LEVEL 100.0000 PPM FEMALES ANIMAL NO. 3531 3532 3533 3534 3535 3536 3537 3538 3539 3541 3543 3545 3547 3549 3550 3551 3553 3554 3555 3556 3557 WEIGHT G 135 134 65 87 104 100 104 110 116 59 130 115 150 103 96 117 138 134 132 112 123 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT BFG 002677 REPRODUCTION STUDY 96-4080B E--14 APPENDIX E (eont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 19 DOSE LEVEL 100.0000 PPM FEMALES ANIMAL NO. 3558 3559 3560 3562 3564 3565 3566 3567 3568 WEIGHT G 139 157 140 143 143 129 119 133 141 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT NO. OF ANIMALS 30 MEAN STD. DEV. 121.0 21.9 BFG 002678 REPRODUCTION STUDY 96*40806 E-15 APPENDIX l (cont.) VINYL CHLORIOE C0H6INE0 INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS INOIVIOUAL BODY WEIGHT ANO FOOD CONSUMPTION PREHATING TREATMENT PERIOD - P2 GENERATION WEEK #: 19 DOSE LEVEL 1100.0000 PPM FEMALES ANIMAL NO. 4531 4533 4535 4537 4538 4540 4542 4545 4546 4548 4549 4551 4552 4554 4555 4556 4557 4556 4560 4562 4563 WEIGHT G 141 143 126 142 137 133 131 96 118 75 127 139 119 142 133 108 111 107 140 136 127 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT 6/KG/DAY G/INT BFG 002679 REPRODUCTION STUDY 96-4080B E-16 APPENDIX E (eont.) VINYL CHLORIOE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT ANO FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 19 DOSE LEVEL - 1100.OOOC PPM FEMALES ANIMAL NO. 4564 4566 4568 4570 4572 4574 4575 4577 4579 WEIGHT G 103 135 110 135 132 88 121 60 114 NO. OF ANIMALS 30 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/XG/DAY G/INT MEAN STD. DEV. 121.0 20.7 BFG 002680 REPRODUCTION STUDY 96-40608 -17 APPENOIX E (cent.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOT IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK 4: 20 DOSE LEVEL - 0..0000 PPM MALES ANIMAL NO. 1031 1032 1033 1035 1037 1039 1041 1043 1045 1047 1048 1050 1052 1054 1056 1057 1058 1060 1061 1062 1063 1WEIGHT G 216 118 210 199 168 179 108 189 188 107 95 161 166 172 182 178 146 164 199 183 168 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 44 139 119.4 139 41 89 152.1 89 53 142 129.0 142 55 131 127.3 131 46 123 141.4 123 43 125 132.3 125 33 68 160.3 88 42 125 124.0 125 51 138 141.5 138 39 63 158.1 83 35 76 163.4 76 38 118 138.5 118 42 126 127.3 126 39 122 133.3 122 44 122 127.1 122 46 126 37 118 137.6 154.2 128 118 24 121 117.2 121 42 139 130.1 139 46 123 128.1 123 45 116 132.9 116 WT. CHG FROM WEEK 19 44 41 S3 55 46 43 33 42 51 39 35 38 42 39 44 46 37 24 42 46 45 BFG 002681 REPRODUCTION STUDY 96-40808 -18 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BOOT WEIGHT AND FOOO CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK *: 20 DOSE LEVEL - 0.0000 PPM MALES ANIMAL NO. 1064 1066 1068 1070 1071 1072 1074 1076 1078 WEIGHT G 197 19S 206 176 196 217 216 216 207 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 46 134 128.4 134 43 127 122.0 127 48 136 124.5 136 50 135 149.0 135 32 137 126.9 137 45 147 126.0 147 44 152 130.6 152 48 146 126.7 146 49 150 137.0 150 WT. CHG. FROM WEEK 19 46 43 48 SO 32 45 44 48 49 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 178.7 43.0 125.2 134.9 125.2 43.0 STD. DEV. 33.6 6.5 19.2 12.4 19.2 6.5 BFG 002682 REPRODUCTION STUDY 96-40808 E-19 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOO CONSUMPTION PREMATING TREATMENT PERIOO - P2 GENERATION WEEK #: 20 DOSE LEVEL - 10.0000 PPM MALES ANIMAL NO. 2031 2033 2034 2036 2037 2038 2040 2042 2044 2046 2048 2050 2052 2054 2056 2058 2060 2062 2064 2066 2067 WEIGHT G 208 235 19S 220 210 164 151 152 198 170 197 156 153 190 210 245 193 186 215 195 194 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 48 135 122.3 135 53 146 116.7 146 48 142 138.4 142 48 144 122.4 144 57 139 127.6 139 42 112 130.5 112 29 102 124.5 102 44 111 142.3 111 52 135 130.8 135 49 127 145.5 127 47 128 123.0 128 39 113 136.0 113 34 115 140.9 115 42 129 127.2 129 49 144 129.4 144 60 170 131.8 170 50 145 143.8 145 49 130 134.2 130 56 154 137.3 154 38 123 116.5 123 41 117 112.4 117 WT. CHG FROM WEEK 19 48 53 46 48 57 42 29 44 52 49 47 39 34 42 49 60 50 49 56 36 41 BFG 002683 REPRODUCTION STUDY 96-40800 E-20 APPENOIX E Ccont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BOOT WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOO - P2 GENERATION WEEK #: 20 DOSE LEVEL - 10.0000 PPM MALES ANIMAL NO. 2068 2070 2072 2073 2074 2075 2076 2077 2078 WEIGHT G 196 187 178 192 187 192 194 219 221 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT 6/KG/DAY G/INT 39 122 US.2 122 42 130 130.5 130 44 123 131.4 123 50 135 134.7 135 48 144 147.2 144 44 139 136.3 139 40 129 123.6 129 47 138 117.6 138 50 153 130.1 153 WT. CHG FROM WEEK 19 39 42 44 50 48 44 40 47 50 NO. OF ANIMALS 30 30 30 30 30 30 MEANS STO. DEV. 193.5 23.5 46.0 6.7 132.5 14.8 130.0 9.4 132.5 14.8 46.0 6.7 BFG 002684 REPRODUCTION STUDY 96-40806 E-21 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CO RATS INDIVIDUAL 800Y WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 20 DOSE LEVEL - 100.0000 PPM MALES ANIMAL NO. 3031 3032 3033 3034 3035 3037 3039 3041 3042 3043 3045 3046 3047 3048 3049 3050 3051 3052 3055 3057 3058 WEIGHT G 232 236 134 150 149 203 161 104 99 216 204 196 215 246 155 153 186 192 211 167 171 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 46 148 118.6 148 53 153 121.7 153 38 101 146.4 101 63 lie 166.0 118 47 106 143.4 108 46 130 120.4 130 40 117 138.3 117 39 82 161.7 82 34 75 152.4 75 S3 144 126.6 144 55 151 142.6 151 56 142 140.9 142 43 139 119.7 139 51 154 116.4 154 42 113 140.5 113 43 116 147.0 116 40 136 134.9 136 43 132 129.0 132 43 140 46 130 123.1 150.5 140 130 47 133 150.3 133 WT. CHS FROM WEEK 19 48 S3 38 63 47 46 40 39 34 S3 55 56 43 51 42 43 40 43 43 46 47 bfg 002685 REPRODUCTION STUDY 96-4060B E-22 APPENDIX E (contO VINYL CHLORIDE COHBINEO INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS INDIVIDUAL BODY WEIGHT AND POOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 20 DOSE LEVEL 100.0000 PPM MALES ANIMAL NO. 30S9 3061 3063 3064 3065 3066 3067 3069 3070 WEIGHT G 213 200 248 216 204 202 200 215 196 WEIGHT FOOD CONSUMPTION CHAN6E ACTUAL CHANGE G G/INT G/KG/DAY G/INT 47 138 121.4 138 52 136 130.3 136 57 161 122.2 161 52 140 122.8 140 45 138 126.7 138 46 140 130.4 140 54 S S S 55 150 133.3 150 45 140 134.5 140 WT. CHG FROM WEEK 19 47 52 57 52 45 46 54 55 45 S - SPILLAGE NO. OF ANIMALS 30 30 29 29 29 30 MEANS 189.2 47.4 131.2 134.9 131.2 47.4 STO. DEV. 37.8 6.6 20.4 13.4 20.4 6.6 BFG 002686 REPRODUCTION STUDY 96-4080B E-23 APPEHQ1X e (eont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT ANO FOOO CONSUMPTION PREMATING TREATMENT PERIOD > P2 GENERATION WEEK #: 20 DOSE LEVEL - 1100.0000 PPM MALES ANIMAL NO. 4031 4033 4035 4037 4039 4041 4043 4045 4046 4047 4049 4050 4052 4054 4056 4058 4060 4062 4064 4066 4066 WEIGHT G 219 199 186 216 21B 192 165 151 185 204 132 171 216 154 178 161 174 147 220 185 215 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 50 143 122.9 143 47 121 114.9 121 51 133 138.1 133 51 147 128.6 147 54 141 123.0 1*1 45 129 126.8 129 39 127 145.5 127 43 139 145.2 139 46 135 138.9 135 45 147 135.0 147 42 93 139.6 93 37 121 132.2 121 45 144 124.0 144 37 119 146.4 119 37 116 121.2 116 41 121 143.5 121 51 12B 143.7 128 36 107 138.2 107 53 151 130.1 151 49 137 1*2.3 137 52 160 141.1 160 WT. CHG FROM WEEK 19 50 47 51 51 54 45 39 43 46 45 *2 37 45 37 37 41 51 36 S3 49 52 BFG 002687 REPRODUCTION STUDY 96-40808 E-24 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 20 DOSE LEVEL - 1100.0000 PPM MALES ANIMAL NO. 4070 4071 4072 4073 4074 4076 4077 4079 4081 WEIGHT G 198 199 222 212 204 146 165 143 156 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 48 138 132.2 138 51 141 135.4 141 48 147 123.7 147 43 133 116.4 133 45 140 128.6 140 41 110 146.1 110 32 110 123.0 110 36 112 37 123 149.3 149.1 112 123 WT. CHG FROM WEEK 19 48 51 48 43 45 41 32 36 37 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 185.4 44.4 130.4 134.2 130.4 44,4 STD. DEV. 26.8 6.1 15.3 10.1 15.3 6.1 BFG 002688 REPRODUCTION STUDY 96-40808 E-25 APPENDIX E (eont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS INDIVIDUAL BODY WEIGHT ANO POOO CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 20 DOSE LEVEL - 0..0000 PPM FEMALES ANIMAL NO. 1531 1533 1535 1537 1538 1539 1540 1541 1542 2543 1545 1547 1549 1551 1553 1555 1557 2558 1559 1561 1563 WEIGHT G 152 116 155 157 ISO 157 120 139 160 161 133 103 96 170 163 144 147 129 141 136 150 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 20 104 122.1 104 42 83 244.9 83 26 no 129.1 110 29 106 124.0 106 32 98 121.9 98 30 122 143.2 122 25 94 145.7 94 13 107 134.6 107 25 115 24 102 129.9 114.1 115 102 28 98 137.3 98 37 76 149.9 76 35 79 167.7 79 30 114 122.6 114 25 109 120.7 109 24 98 123.7 98 30 105 24 97 132.6 232.5 106 97 20 102 129.8 102 29 98 134.4 98 26 107 130.2 107 WT. CHG. FROM WEEK 19 20 41 26 29 32 30 25 13 25 24 28 37 35 30 25 24 30 14 20 29 26 BFG 002689 REPRODUCTION STUDY 96-4080B E-26 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL 800Y WEIGHT AND FOOO CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 20 DOSE LEVEL - 0.0000 PPM FEMALES ANIMAL NO. 1565 1566 1566 1570 1572 1574 1576 1578 1580 WEIGHT G 146 167 143 166 156 141 163 150 142 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE 6 G/INT G/KG/DAY G/INT 26 98 122.8 98 27 115 124.9 115 23 99 125.5 99 29 106 116.6 106 30 119 140.7 119 19 113 143.2 113 29 114 127.9 114 21 103 123.1 103 22 104 132.3 104 WT. CHG FROM WEEK 19 26 27 23 29 30 19 29 21 22 NO. OF AN1HALS 30 30 30 30 30 30 MEANS STO. DEV. 145.1 18.1 26.3 6.0 103.2 10.8 131.6 11.3 103.2 10.8 26.3 6.0 BFG 002690 REPRODUCTION STUDY 96-4QBOB E-27 APPENDIX E (cont.) VINYL CHLORIOE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK t: 20 DOSE LEVEL - 10. 0000 PPM FEMALES ANIMAL NO. 2532 2533 2534 2536 2536 2540 2541 2543 2544 2546 2548 2550 2552 2553 2554 2555 2556 2557 2556 2559 2561 WEIGHT G 161 155 190 148 164 141 156 129 149 156 155 120 155 159 164 163 165 161 177 164 137 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 25 110 123.5 110 21 102 42 134 117.6 132.1 102 134 23 103 125.8 103 27 113 125.1 113 31 101 134.1 101 26 108 124.1 108 26 97 140.6 97 16 107 126.5 107 37 114 138.2 114 26 113 132.6 113 23 99 152.1 99 30 110 131.0 110 25 105 119.S 105 31 115 129.1 115 23 106 118.6 106 25 112 122.4 112 18 116 112.4 116 16 115 113.4 115 23 122 133.3 122 27 111 149.8 111 WT. CHS FROM WEEK 19 25 21 42 23 27 31 26 28 16 37 26 23 30 25 31 23 25 18 16 23 27 BFG 002691 REPRODUCTION STUDY 96-40808 E-28 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY HEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOO - P2 GENERATION HEEK I: 20 DOSE LEVEL - 10.0000 PPM FEMALES ANIMAL NO. 2563 2565 2566 2567 2569 2571 2573 2575 2577 HEIGHT HEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G 6 G/INT G/KG/DAY G/INT 145 23 107 133.6 107 ANIMAL EXPIRED 160 22 116 129.8 116 150 19 105 124.6 105 149 25 109 133.1 109 142 22 102 129.8 102 140 31 106 141.9 106 159 22 115 129.5 115 144 22 107 134.1 107 WT. CHG. FROM WEEK 19 23 22 19 25 22 31 22 22 NO. OF ANIMALS 29 29 29 29 29 29 MEANS STO. DEV. 154.5 14.7 25.1 5.7 109.7 7.4 129.6 9.4 109.7 7.4 25.1 5.7 002692 REPRODUCTION STUDY 96-4080B E-Z9 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL 80DY WEIGHT AND POOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 20 DOSE LEVEL - 100.0000 PPM FEMALES ANIMAL NO. 3531 3532 3533 3534 3535 3536 3537 3538 3539 3541 3543 3545 3547 3549 3550 3551 3553 3554 3555 3556 3557 !WEIGHT G 162 162 123 125 140 126 121 135 142 94 157 140 173 136 136 143 158 167 155 128 152 WEIGHT POOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/K6/DAY G/INT 27 111 124.6 111 28 115 129.5 115 38 92 38 102 147.4 160.4 92 102 36 100 26 98 17 94 136.6 144.5 139.3 100 98 94 25 97 132.0 97 24 97 124.4 97 35 T T T 27 115 133.6 115 25 107 23 106 35 106 40 108 139.9 109.4 146.6 155.2 107 106 106 108 26 103 20 111 33 115 23 104 132.1 125.0 127.4 120.6 103 111 115 104 16 100 29 107 138.9 129.7 100 107 WT. CHG PROM WEEK 19 27 26 38 38 36 26 17 25 24 35 27 25 23 35 40 26 20 33 23 16 29 BFG 002693 REPRODUCTION STUDY 96-4Q80B E-30 APPENOIX E (eont.) VINYL CHLORIDE COMBINED INHALATION TWO-SENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PZ GENERATION WEEK #: 20 DOSE LEVEL - 100.0000 PPM FEMALES ANIMAL NO. 3556 3559 3560 3562 3564 3565 3566 3567 3568 WEIGHT G 174 175 166 156 167 145 144 161 174 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 35 129 137.4 129 18 114 114.5 114 26 122 132.9 122 15 115 127.4 115 24 114 122.6 114 16 107 130.2 107 25 106 136.9 108 28 127 144.0 127 33 122 129.1 122 WT. CHG FROM WEEK 19 35 18 26 15 24 16 25 28 33 T - TECHNICAL PROBLEM NO. OF ANIMALS 30 30 29 29 29 30 MEANS 146.0 27.0 108.5 133.5 108.5 27.0 STD . DEV. 19.4 7.1 9.4 11.2 9.4 7.1 BFG 002694 REPRODUCTION STUDY 96-40808 -31 APPENDIX E (cont.) VINYL CHLORIDE C0M61NE0 INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 20 DOSE LEVEL - 1100.0000 PPM FEMALE5 ANIMAL NO. 4531 4533 4535 4537 4538 4540 4542 4545 4546 4548 4549 4551 4552 4554 4555 4556 4557 4558 4560 4562 4563 iHEIGHT G 171 157 152 162 167 166 159 127 142 111 157 170 156 169 158 134 142 139 168 159 151 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 30 116 123.9 116 14 142 157.8 142 26 107 128.3 107 20 109 119.5 109 30 117 128.3 117 33 116 129.3 116 28 119 136.8 119 31 96 143.5 96 24 108 13S.5 108 36 91 163.1 91 30 122 143.2 122 31 120 129.4 120 37 116 140.6 116 27 122 130.6 122 25 109 124.9 109 26 109 iso.i 109 31 110 144.9 110 32 106 143.6 106 28 115 124.5 115 23 107 120.9 107 24 109 130.7 109 VT. CHG FROM WEEK 19 30 14 26 20 30 33 28 31 24 36 30 31 37 27 25 26 31 32 28 23 24 BFG 002695 REPRODUCTION STUDY 96-A030B E-32 APPENDIX E (cont.) VINYL CHLORIOE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIO0 - P2 GENERATION WEEK #: 20 DOSE LEVEL - 1100.0000 PPM FEMALES ANIMAL NO. 4564 4566 4568 4570 4572 4574 4575 4577 4579 WEIGHT G 130 166 141 156 160 115 140 86 142 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 27 105 150.2 105 31 122 135.1 122 31 109 144.8 109 21 106 123.7 108 28 120 137.0 120 27 97 159.3 97 19 102 130.3 102 26 78 178.1 78 28 110 143.2 110 WT. CHG FROM WEEK 19 27 31 31 21 23 27 19 26 28 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 148.4 27.5 110.6 138.5 110.6 27.5 STO. OEV. 19.8 4.9 11.4 13.a 11.4 4.9 BFG 002696 REPRODUCTION STUDY 96-40800 E-33 APPENQIX fcont.) VINYL CHLORIDE COWINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS INDIVIDUAL BODY WEI6HT AND POOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 21 DOSE LEVEL - 0.0000 PPM MALES ANIMAL NO. 1031 1032 1033 1035 1037 1039 1041 1043 104S 1047 1048 1050 1052 1054 1056 1057 1058 1060 1061 1062 1063 WEIGHT WEIGHT POOO CONSUMPTION CHANGE ACTUAL CHANGE G G G/INT G/KG/DAY G/INT 261 45 154 107.6 15 161 63 124 138.2 35 274 64 181 124.7 39 255 56 154 113.1 23 218 SO 141 121.8 18 234 55 144 116.2 19 151 43 114 146.7 26 235 46 137 107.7 12 251 63 169 126.3 31 167 60 127 154.5 44 146 SI 112 154.9 36 ANIMAL EXPIRED 244 58 151 117.1 25 224 52 159 133.8 37 242 60 155 121.9 33 232 197 54 154 51 144 125.2 139.9 26 26 249 65 152 117.0 31 255 56 152 111.6 13 242 59 145 113.7 22 221 53 142 121.7 26 WT. CHG PROM WEEK 19 89 104 117 111 96 98 76 88 114 99 86 100 91 104 100 88 89 96 105 98 BFG 002697 REPRODUCTION STUDY 96-4060B E-34 APPENOIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY HEIGHT ANO FOOD CONSUMPTION PREMATING TREATMENT PEAIOO - P2 GENERATION WEEK #: 21 OOSE LEVEL 0.0000 PPM MALES ANIMAL NO. 1064 1066 1068 1070 1071 1072 1074 1076 107B 1WEIGHT G 251 244 259 235 256 281 268 277 264 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 54 157 116.8 23 49 147 111.6 20 53 150 107.5 14 59 161 130.6 26 60 154 113.6 17 64 172 52 166 115.1 114.3 25 14 61 17B 120.4 32 57 177 125.3 27 WT. CHG. FROM WEEK 19 100 92 101 109 92 109 96 109 106 NO. OF ANIMALS 29 29 29 29 29 29 MEANS 235.0 55.6 150.B 123.1 25.3 96.8 STD. DEV. 35.5 5.9 17.2 13.2 6.4 9.4 BFG 002698 REPRODUCTION STUDY 96-40808 E-35 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION THO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY HEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 21 DOSE LEVEL 10.0000 PPM KALES ANIMAL NO. 2031 2033 2034 2036 2037 2038 2040 2042 2044 2046 2046 2050 2052 2054 2056 2058 2060 2062 2064 2066 2067 HEIGHT G 257 298 251 288 262 218 195 208 255 222 255 196 169 242 267 314 234 240 276 260 255 HEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G 6/INT G/KG/OAY G/INT 49 151 106.2 16 63 177 110.7 31 56 163 121.8 21 68 183 120.1 39 52 167 117.9 28 54 143 124. B 31 44 121 116.6 19 56 140 129.6 29 57 166 122.1 31 52 148 125.9 21 58 154 113.6 26 38 S S S 36 122 118.9 7 52 142 109.6 13 57 161 112.5 17 69 190 113.3 20 41 148 115.5 3 54 142 111.1 12 61 175 118.8 21 65 154 112.8 31 61 155 115.1 38 HT. CHG FROM UEEK 19 97 116 104 116 109 96 73 100 109 101 105 77 70 94 106 129 91 103 117 103 102 BFG 002699 REPRODUCTION STUDY 96-4080B -36 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY HEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 21 DOSE LEVEL * 10.0000 PPM MALES ANIMAL NO. 2068 2070 2072 2073 2074 207S 2076 2077 2078 HEIGHT G 250 236 234 242 238 243 244 276 280 HEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 54 145 108.4 23 49 150 118.2 20 56 148 119.7 25 50 156 119.8 21 51 158 123.9 14 51 166 127.2 27 50 151 114.9 22 57 157 59 184 105.7 122.4 19 31 WT. CH6 FROM WEEK 19 93 91 100 100 99 95 90 104 109 S - SPILLAGE NO. OF ANIMALS 30 MEANS 247.5 30 54.0 29 155.8 29 117.2 29 22.6 30 100.0 STO. DEV. 29.3 7.8 16.3 6.1 8.4 12.5 BFG 002700 REPRODUCTION STUDY 96-4080B -37 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOO - P2 GENERATION WEEK #: 21 DOSE LEVEL 100. 0000 PPM MALES ANIMAL NO. 3031 3032 3033 3034 3035 3037 3039 3041 3042 3043 3045 3046 3047 3048 3049 3050 3051 3052 3055 3057 3058 1WEIGHT G 284 296 182 206 188 260 211 156 145 273 252 255 276 312 209 197 228 246 254 218 224 WEIGHT FOQO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 52 169 109.2 21 60 172 107.8 19 48 134 141.4 33 56 149 139.5 31 39 129 127.6 21 57 158 113.8 28 50 135 121.0 18 52 120 153.8 38 46 109 148.9 34 57 163 111.1 19 46 176 128.7 25 59 177 130.8 35 61 161 109.3 22 66 180 54 132 107.5 120.9 26 19 44 131 124.6 15 40 141 113.0 5 54 153 116.4 21 43 147 105.4 7 51 151 130.7 21 53 147 124.1 14 NT. CHG FROM WEEK 19 100 113 86 119 86 103 90 91 80 110 103 115 104 117 96 87 60 97 86 97 100 BFG 002701 REPRODUCTION STUDY 96-40606 E-38 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY HEIGHT AND FOOO CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 21 DOSE LEVEL 100.0000 PPM MALES ANIMAL NO. 3059 3061 3063 3064 3065 3066 3067 3069 3070 !WEIGHT G 266 256 308 271 254 248 268 282 248 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 53 157 109.3 19 56 159 116.2 23 60 182 109.1 21 55 165 112.9 25 50 170 123.7 32 46 165 122.2 25 68 189 134.6 T 67 180 120.7 30 52 166 124.6 26 T - TECHNICAL PROBLEM WT. CHS FROM WEEK 19 100 108 117 107 95 92 122 122 97 NO. OF ANIMALS 30 MEANS 242.4 STD. DEV. 41.8 30 53.2 7.3 30 155.6 20.0 30 122.0 12.6 29 23.2 7.7 30 100.7 12.3 BFG 002702 REPRODUCTION STUDY 96-40808 -39 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TVO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS WEEK 4: INDIVIDUAL BODY HEIGHT ANO FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION 21 DOSE LEVEL 1100.0000 PPM MALES ANIMAL NO. 4031 4033 4035 4037 4039 4041 4043 4045 4046 4047 4049 4050 4052 4054 4056 4058 4060 4062 4064 4066 4068 WEIGHT 6 279 255 245 2B5 276 251 207 233 241 2sa 190 227 280 191 214 210 227 191 270 246 272 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE 6 G/INT G/KG/DAY G/INT 60 164 109.8 21 56 147 107.9 26 59 150 116.0 17 69 172 114.4 25 56 166 112.0 25 59 156 117.4 27 42 135 121.0 8 52 150 120.8 11 56 157 122.8 22 54 162 116.9 15 58 139 143.9 46 56 147 64 168 123.1 112.9 26 24 37 128 123.7 9 36 12B 108.8 12 49 147 132.1 26 53 148 123.0 20 44 126 124.3 19 50 164 111.6 13 61 160 123.7 23 57 173 118.4 13 WT. CHG. FROM WEEK 19 110 103 110 120 112 104 81 95 102 99 100 93 109 74 73 90 104 80 103 110 109 BFG 002703 REPRODUCTION STUDY 96-4Q80B E-40 APPENDIX E (cont.j VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BOOY HEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 21 OOSE LEVEL - 1100.0000 PPM MALES ANIMAL NO. 4070 4071 4072 4073 4074 4076 4077 4079 4061 WEIGHT G 257 260 271 260 262 194 204 175 194 NO. OF ANIMALS 30 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G 6/INT G/ICG/DAY G/INT 59 164 120.1 26 61 169 122.7 28 49 156 106.8 11 46 150 105.9 17 56 159 113.7 19 46 132 129.4 22 39 125 112.9 15 32 118 123.7 6 38 132 125.7 9 30 30 30 30 WT. CHS FROM WEEK 19 107 112 97 91 103 89 71 66 75 30 MEANS 237.5 52.1 149.8 118.9 19.4 96.5 STD. DEV. 33.0 9.2 15.6 6.3 6.3 14.3 BFG 002704 REPRODUCTION STUDY 96-4080B E-41 APPEHDIX Z (cont.) VINYL CHLORIDE COMBINED INHALATION 7W0-SENERATI0N REPRODUCTION MO DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BOOY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PZ GENERATION WEEK #: 21 DOSE LEVEL * 0.0000 PPM FEMALES ANIMAL NO. 1531 1533 1S3S 153? 1536 1539 1540 1541 1542 1543 1545 1547 1549 1551 1553 1555 1557 1556 1559 1561 1563 WEIGHT G 177 159 161 174 185 176 144 163 177 181 1S9 146 132 196 194 164 169 157 156 159 174 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 25 110 111.4 6 43 116 140.6 33 26 119 118.1 9 17 91 91.6 -15 35 120 119.4 22 19 116 116.1 -6 24 104 131.3 10 24 107 lie. i 0 17 108 106.8 -7 20 105 102.3 3 26 105 119.9 7 45 10S 139.4 29 36 99 144.7 20 26 125 113.8 11 31 120 112.0 11 20 106 114.7 8 22 114 120.3 9 28 101 117.7 4 15 95 106.6 -7 23 104 117.5 6 24 112 115.2 5 WT. CHG FROM WEEK 19 45 84 52 46 67 49 49 37 42 44 54 82 71 56 56 44 52 42 35 52 50 BFG 002705 REPRODUCTION STUDY 96-40606 E-42 APPENOIX E (com.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK t: 21 DOSE LEVEL - 0.0000 PPM FEMALES ANIMAL NO. 1565 1566 1566 1570 1572 1574 1576 1578 1560 WEIGHT G 170 166 156 194 161 161 163 165 166 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 24 105 110.8 7 19 116 109.5 1 13 97 108.1 -2 26 121 112.0 15 25 127 125.6 8 20 no 20 119 121.4 114.6 -3 5 15 105 111.1 2 24 100 108.2 -4 WT. CHG FROM WEEK 19 50 46 36 57 55 39 49 36 46 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 169.6 24.5 109.4 116.6 6.2 SO.8 STD,. OEV. 15.2 7.6 9.1 11.2 10.4 12.1 BFG 002706 REPRODUCTION STUDY 96-40808 E-43 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND POOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK *: 21 DOSE LEVEL - 10.0000 PPM FEMALES ANIMAL NO. 2532 2533 2534 2536 2538 2540 2S41 2543 2544 2546 2548 2550 2552 2553 2554 2555 2556 2557 2558 2559 2561 WEIGHT G 190 184 199 178 192 168 184 159 160 183 173 136 172 182 194 193 184 201 199 175 165 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 29 120 114.0 10 29 115 113.1 13 9 US 98.5 -19 30 118 120.7 15 29 111 103.9 -2 27 109 26 115 117.6 112.1 8 7 30 11B 136.6 21 11 101 109.0 -6 27 119 117.0 5 18 104 105.7 -9 16 101 131.5 2 17 109 23 no 111.1 107.5 -1 5 30 120 111.7 5 30 127 19 125 118.9 119.4 19 13 20 119 103.8 3 22 127 112.6 12 11 116 28 106 114.1 117.0 -6 -5 WT. CHG. FROM WEEK 19 54 50 51 53 55 58 52 58 27 64 44 39 47 48 61 53 44 38 38 34 55 BFG 002707 REPRODUCTION STUDY 96-4Q80B E-44 APPENDIX E (coot.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PZ GENERATION WEEK #: 21 DOSE LEVEL - 10.0000 PPM FEMALES ANIMAL NO. 2563 2566 2567 2569 2571 2573 2575 2577 WEI6HT G 173 183 173 164 158 168 163 166 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT 6/KG/DAY G/INT 28 111 116.4 4 23 117 113.7 1 23 S S S 15 106 112.9 -3 16 101 112.2 -1 28 121 131.0 15 24 121 117.9 6 22 119 128.0 12 WT. CHS. FROM WEEK 19 SI 45 42 40 38 59 46 44 S - SPILLAGE NO. OF ANIMALS 29 MEANS 177.2 STD. DEV. 14.7 29 22.7 6.4 28 114.3 7.6 28 115.3 8.6 28 4.4 9.1 29 47.9 8.8 BFG 002708 REPRODUCTION STUDY 96-408QB E-45 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND POOD CONSUMPTION PREMATING TREATMENT PERIOD P2 GENERATION WEEK #: 21 DOSE LEVEL - 100.0000 PPM FEMALES ANIMAL NO. 3531 3532 3533 3534 3535 3536 3537 3536 3539 3541 3543 3545 3547 3549 3550 3551 3553 3554 3555 3556 3557 WEIGHT G 186 191 146 155 164 152 142 157 154 127 193 160 197 164 155 162 162 191 178 152 166 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 24 114 109.2 3 29 123 116.1 8 25 107 131.6 15 30 113 24 110 134.5 120.6 11 10 26 106 127.1 6 21 95 120.4 1 22 110 125.6 13 12 98 110.4 1 33 102 153.8 T 36 130 123.8 15 20 115 127.8 8 24 114 102.7 8 26 108 119.2 2 19 111 127.1 3 19 112 122.4 9 24 108 105.9 -3 24 124 115.5 9 23 123 123.1 19 24 115 136.9 15 14 112 117.4 5 WT. CHG. FROM WEEK 19 51 57 63 68 60 52 38 47 36 68 63 45 47 61 59 45 44 57 46 40 43 BFG 002709 REPRODUCTION STUDY 96-40808 E-46 APPENOIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL 800Y WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 21 DOSE LEVEL - 100. 0000 PPM FEMALES ANIMAL NO. 3558 3559 3560 3562 3564 3565 3566 3567 3568 WEIGHT G 184 203 200 197 189 162 174 193 204 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 10 118 109.9 -11 28 128 112.9 14 34 132 120.2 10 39 132 123.9 17 22 126 118.0 12 17 106 115.1 -1 30 120 125. B 12 32 136 128.1 9 30 135 119.0 13 WT. CHG FROM WEEK 19 45 46 60 54 46 33 55 60 63 T - TECHNICAL PROBLEM NO. OF ANIMALS 30 30 30 30 29 30 MEANS 172.7 24.7 116.1 121.5 8.1 51.7 STD. DEV. 20.6 6.8 10.8 10.1 6.7 9.6 BFG 002710 REPRODUCTION STUDY 96-40808 E-47 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND POOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK t: 21 DOSE LEVEL - 1100.0000 PPM FEMALES ANIMAL NO. 4531 4533 4535 4537 4538 4540 4542 4545 4546 4548 4549 4551 4552 4554 4555 4556 4557 4558 4560 4562 4563 WEIGHT G 207 193 181 189 192 197 179 146 162 154 184 207 189 201 190 161 167 163 19S 181 174 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 36 126 36 118 111.1 112.4 10 -24 29 114 114.1 7 27 115 109.2 6 25 118 31 121 20 110 109.6 111.1 108.5 1 5 -9 21 107 20 105 129.7 115.1 11 -3 43 120 150.9 29 27 129 126.1 7 37 131 115.8 11 33 123 118.8 7 32 123 110.8 1 32 119 114.0 10 27 111 25 113 125.4 121.9 2 3 24 109 120.3 3 27 128 117.5 13 22 111 108.8 4 23 115 117.9 6 NT. CHG FROM WEEK 19 66 SO 55 47 55 64 48 52 44 79 57 68 70 59 57 53 56 56 55 45 47 BFG 002711 REPRODUCTION STUDY 96-4080B E-48 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BOOT WEIGHT AND FQOO CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK f: 21 DOSE LEVEL 1100.0000 PIM FEMALES ANIMAL NO. 4564 4566 4566 4570 4572 4574 4575 4577 4579 WEIGHT G 154 169 171 176 167 132 165 102 161 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 24 105 123.2 0 23 126 118.3 4 30 112 119.7 3 20 115 27 124 115.5 119.1 7 4 17 104 140.4 7 25 101 110.4 -1 16 92 163.1 14 19 no 121.0 0 WT. CHG FROM WEEK 19 51 54 61 41 55 44 44 42 47 NO. OF ANIMALS 30 30 30 30 30 30 MEANS STO. DEV. 175.0 22.8 26.6 6.4 115.2 9.1 120.0 12.4 4.6 8.5 54.1 9.0 BFG 002712 REPRODUCTION STUDY 96-406OB -49 APPENDIX E (cont.) VINYL CHLORIOE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUOY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOO CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 22 DOSE LEVEL - 0.0000 PPM MALES ANIMAL NO. 1031 1032 1033 1035 1037 1039 1041 2D43 1045 1047 1048 1052 1054 1056 1057 1056 1060 1061 1062 1063 1064 WEIGHT <3 310 236 331 307 260 260 193 276 301 223 190 292 273 287 279 244 305 304 301 276 303 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHAN6E 5 6/lNT G/KS/DAr G/1HT 49 166 96.1 14 55 156 126.3 34 57 192 105.8 11 52 156 96.5 12 42 156 106.8 15 46 146 94.7 2 42 126 122.1 12 43 147 95.5 10 50 171 103.3 2 56 151 129.1 24 44 130 129.0 18 48 164 102.0 13 49 160 107.3 1 45 161 101.4 6 47 151 96.5 -3 47 149 112.6 5 56 165 111.3 33 49 177 105.5 25 59 161 98.6 16 55 152 101.9 10 52 174 104.7 17 WT, CHG FROM WEEK 19 138 159 174 163 138 144 116 131 164 155 130 148 140 149 147 135 145 147 164 153 152 BFG 002713 REPRODUCTION STUDY 96-40808 E-50 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERI00 - P2 GENERATION WEEK #: 22 DOSE LEVEL - 0.0000 PPM MALES ANIMAL NO. 1066 1066 1070 1071 1072 1074 1076 1078 WEIGHT G 271 312 2B6 299 321 306 319 321 NO. OF ANIMALS 29 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 27 146 94.5 -1 53 166 98.1 18 51 175 112.0 14 43 159 40 178 95.5 98.6 5 6 36 166 96.4 0 42 173 96.8 -5 57 174 99.1 -3 29 29 29 29 WT. CHG FROM WEEK 19 119 154 160 135 149 134 151 163 29 MEANS 283.0 48.1 161.5 105.0 10.7 146.9 STD. DEV. 36.1 7.0 15.0 10.2 10.1 13.6 BFG 002714 REPRODUCTION STUDY 96-4080B E-51 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS WEEK #: INDIVIDUAL BODY WEIGHT AND FOOO CONSUMPTION PREMATING TREATMENT PERIOO - PZ GENERATION 22 DOSE LEVEL - 10.0000 PPM MALES ANIMAL NO. 2031 2033 2034 2036 2037 2038 2040 2042 2044 2046 2048 2050 2052 2054 2056 2058 2060 2062 2064 2066 2067 WEIGHT G 303 358 311 347 325 271 229 265 302 278 307 23S 222 294 328 370 274 297 333 312 315 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 46 162 96.4 11 60 191 97.1 14 60 191 113.3 28 59 196 102.9 13 63 1B7 106.2 20 53 157 107.0 14 34 136 108.5 17 57 168 118.4 28 47 1B2 108.9 16 56 174 116.0 26 52 173 102.6 19 39 136 105.2 I 33 128 103.8 6 52 166 103.2 24 61 180 100.8 19 56 205 99.9 15 40 154 101.0 6 57 176 109.2 34 57 190 104.0 15 52 173 100.8 19 60 178 104.1 23 WT. CHG FROM WEEK 19 143 176 164 175 172 149 107 157 156 157 157 116 103 146 167 185 131 160 174 155 162 BFG 002715 REPRODUCTION STUDY 96-40608 E-S2 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSLMPTION PREMATIN6 TREATMENT PERIOD - P2 GENERATION WEEK #: 22 DOSE LEVEL 10.0000 PPM MALES ANIMAL NO. 2068 2070 2072 2073 2074 2075 2076 2077 2078 WEIGHT G 294 286 279 268 293 290 288 326 340 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 44 157 96.2 12 50 167 106.6 17 45 161 104.6 13 46 170 106.9 14 55 183 114.9 25 47 177 110.7 11 44 166 105.3 17 50 174 96.3 17 60 192 103.2 6 WT. CHG FROM WEEK 19 137 141 145 146 154 142 134 154 169 T - TECHNICAL. PROBLEM NO. OF ANIMALS 30 30 30 30 29 30 MEANS 298.7 51.2 171.8 105.1 17.3 151.1 STD. OEV. 35.0 B.l 17.8 5.7 5.7 19.6 BFG 002716 REPRODUCTION STUDY 96-4080B E-53 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TVO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD > P2 GENERATION WEEK #: 22 DOSE LEVEL 100.0000 PPM MALES ANIMAL NO. 3031 3032 3033 3034 303S 3037 3039 3041 3042 3043 3045 3046 3047 3048 3049 3050 30S1 3052 3055 3057 3058 1WEIGHT G 350 342 222 258 228 304 249 194 183 318 292 309 323 346 257 237 262 300 296 258 282 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 66 194 102.0 25 46 184 96.1 12 40 144 118.8 10 52 173 124.3 24 40 136 109.0 7 44 167 98.7 9 38 142 102.9 7 38 134 127.6 14 38 121 123.0 12 45 177 99.8 14 40 184 112.7 8 54 201 116.8 24 47 174 96.8 13 34 186 94.2 5 48 148 105.9 16 40 140 107.5 9 34 151 102.7 10 54 164 100.1 11 44 159 96.0 12 40 172 120.4 21 58 168 110.7 21 WT. CHG. FROM WEEK 19 166 159 126 171 126 147 128 129 118 155 143 169 151 151 144 127 114 151 130 137 158 BFG 002717 REPRODUCTION STUDY 96-40606 E-54 APPEHOIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TH0-GENERA7ION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOO - P2 GENERATION WEEK #: 22 DOSE LEVEL - 100.0000 PPM MALES ANIMAL NO. 3059 3061 3063 3064 3065 3066 3067 3069 3070 WEIGHT G 315 309 343 320 297 286 320 339 291 NO. OF ANIMALS 30 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 49 162 92.9 5 53 175 103.2 16 35 178 91.1 -4 49 174 98.1 9 43 191 115.5 21 36 178 111.1 13 52 200 113.4 11 57 201 107.9 21 43 175 108.2 9 30 30 30 30 WT. CHG. FROM WEEK 19 149 161 152 156 138 130 174 179 140 30 MEANS STD. DEV. 287.7 44.S 45.3 7.9 168.4 21.2 107.0 10.0 12.9 6.6 146.0 17.2 BFG 002718 REPRODUCTION STUDY 96-4080B E-55 APPENDIX E (cont.) VINYL CHLORIOE COMSINEO INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 22 DOSE LEVEL 1100.0000 PPM MALES ANIMAL NO. 4031 4033 4035 4037 4039 4041 4043 4045 4046 4047 4049 4050 4052 4054 4056 4058 4060 4062 4064 4066 4068 WEIGHT G 322 302 305 341 319 305 243 285 293 294 246 273 327 230 245 259 277 240 319 297 308 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 43 178 98.7 14 47 165 98.7 18 60 176 106.7 26 56 188 100.1 16 43 169 94.7 3 54 176 105.5 20 36 149 110.4 14 52 173 111.3 23 52 179 111.7 22 36 167 100.8 5 56 169 129.2 30 46 168 112.0 21 47 188 103.2 20 39 131 103.7 3 31 130 94.4 2 49 161 114.4 14 50 162 107.1 14 49 140 106.3 14 49 171 96.8 7 51 184 113.0 24 36 171 96.3 -2 WT. CHG FROM WEEK 19 153 150 170 176 155 158 117 147 154 135 156 139 156 113 104 139 154 129 152 161 145 BFG 002719 REPRODUCTION STUDY 96-4080B E-56 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOO CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 22 DOSE LEVEL - 1100.0000 PPM MALES ANIMAL NO. 4070 4071 4072 4073 4074 4076 4077 4079 4061 WEIGHT G 315 318 306 311 299 242 234 210 236 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 56 179 104.3 15 58 187 107.8 IS 35 161 93.0 3 51 169 98.7 19 37 172 102.2 13 48 150 114.7 18 30 123 93.6 -2 35 126 109.1 8 44 152 117.3 20 WT. CHG. FROM WEEK 19 165 170 132 142 140 137 101 103 119 NO. OF ANIMALS 30 30 30 30 30 30 MEANS STD. DEV. 283.4 35.6 45.9 e.s 163.8 18.S 105.3 8.2 14.0 8.4 142.4 20.4 BFG 002720 REPRODUCTION STUDY 96-4080B E-57 APPENDIX E (contO VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PZ GENERATION WEEK #: 22 DOSE LEVEL - 0.0000 PPM FEMALES ANIMAL NO. 1531 1533 1535 1537 1538 1539 1540 1541 1542 1543 1545 1547 1549 1551 1553 1555 1557 1558 1559 1561 1563 WEIGHT G 180 183 200 198 203 200 164 1B2 194 195 182 165 150 221 212 182 184 173 165 178 183 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 3 110 102.7 0 24 124 120.9 8 19 131 114.6 12 24 100 89.6 9 18 12B 110.0 8 24 126 111.7 10 20 113 122.3 9 19 120 115.9 13 17 109 97.9 1 14 no 97.5 5 23 116 113.4 11 17 111 118.2 6 18 112 132.4 13 25 134 107.1 9 18 130 106.7 10 18 121 116.6 15 15 110 103.9 -4 16 105 106.1 4 9 99 102.8 4 19 108 106.8 4 9 110 102.7 -2 WT. CHG. FROM WEEK 19 48 108 71 7D 85 73 69 56 59 58 77 99 89 81 74 62 67 58 44 71 59 BFG 002721 REPRODUCTION STUDY 95-4080B E-58 APPENDIX E (cont.) VINYL CHLORIOE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 22 DOSE LEVEL - 0. 0000 PPM FEMALES ANIMAL NO. 1565 1566 1566 1570 1572 1574 1576 1578 1580 WEIGHT G 188 209 174 222 182 178 211 179 178 NO. OF ANIMALS 30 MEANS 187.2 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 18 112 104.3 7 23 117 98.7 1 18 107 108.1 10 28 127 101.8 6 1 137 125.8 10 17 110 108.2 0 28 124 104.9 5 14 105 101.7 0 12 103 99.8 3 30 30 30 30 17.6 115.6 108.4 6.2 WT. CHG FROM WEEK 19 68 69 54 85 56 56 77 50 58 30 66.4 STO. DEV. 17.2 6.4 10.4 9.3 4.9 14.9 BFG 002722 REPRODUCTION STUDY 96-40808 -59 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITr STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOO CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 22 OOSE LEVEL - 10.0000 PPM FEMALES ANIMAL NO. 2532 2533 2534 2536 2538 2540 2541 2543 2544 2546 2548 2S50 2552 2553 2554 2555 2556 2557 2558 2559 2561 1WEIGHT G 205 199 233 199 210 188 199 173 177 190 189 156 162 199 212 205 203 218 205 206 181 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 15 122 103.0 2 15 121 34 142 105.3 109.6 6 27 21 131 115.8 13 18 121 100.3 10 20 119 111.4 10 15 120 14 122 104.4 122.5 5 4 17 111 109.5 10 7 127 113.S 8 16 112 20 115 103.1 131.3 8 14 10 109 102.6 0 17 114 99.7 4 18 124 101.8 4 12 125 104.7 -2 19 138 118.9 13 17 125 100.2 7 6 117 96.5 -10 33 136 118.4 20 16 116 111.8 10 WT. CHG FROM WEEK 19 69 65 85 74 73 78 67 72 44 71 60 59 57 65 79 65 63 55 44 67 71 BFG 002723 REPRODUCTION STUDY 96-4080B E-60 APPENDIX E (cent.) VINYL CHLORIDE COMB1NEO INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS WEEK #: INOIVIOUAL BOOT WEIGHT ANO FOOD CONSUMPTION PREMATING TREATMENT PERIOO - P2 GENERATION 22 DOSE LEVEL FEMALES 10.0000 PPM ANIMAL NO. 2563 2566 2567 2569 2571 2573 2575 2577 WEIGHT G 189 201 175 181 184 135 186 176 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G 6/1 NT G/KG/OAY G/INT 16 124 114.2 13 18 128 111.1 11 2 112 107.3 T 17 106 102.4 0 26 126 122.8 25 17 137 129.4 16 3 US 103.9 -6 10 115 112.1 -4 T - TECHNICAL PROBLEM WT. CHG FROM WEEK 19 67 63 44 57 64 76 49 54 NO. OF ANIMALS 29 HEANS 193.4 STD. DEV. 16.0 29 16.2 7.2 29 121.8 9.1 29 109.9 9.0 28 7.8 8.6 29 64.0 10.6 BFG 002724 REPRODUCTION STUDY 96-4080B E-61 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INOIYIOUAL BOOY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 22 DOSE LEVEL - 100.0000 PPM FEMALES ANIMAL NO. 3531 3532 3533 3534 3535 3536 3537 3538 3539 3541 3543 3545 3547 3549 3550 3551 3553 3554 3555 3556 3557 WEIGHT G 200 201 162 170 175 169 152 167 173 148 208 177 215 183 173 168 192 223 204 165 192 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 14 117 101.0 3 10 121 102.9 -2 14 113 121.5 6 15 119 IZ2.1 6 11 117 115.0 7 17 109 113.2 3 10 90 111.1 3 10 105 108.0 -5 19 110 112.1 12 21 112 135.8 10 15 130 108.1 0 17 116 114.7 1 16 120 97.1 6 19 113 108.5 5 16 112 113.8 1 6 109 110.1 -3 10 115 102.5 7 32 136 109.5 12 26 123 107.3 a 13 123 129.3 8 26 120 111.7 8 WT. CHG FROM WEEK 19 65 67 77 83 71 69 48 57 55 89 78 62 65 80 77 51 54 89 72 53 69 BFG 002725 REPRODUCTION STUDY 96-4080B E-62 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOO - P2 GENERATION WEEK #: 22 DOSE LEVEL 100..0000 PPM FEMALES ANIMAL NO. 3558 3559 3560 3562 3564 3565 3566 3567 3568 1WEIGHT G 230 22B 226 213 203 172 193 201 215 WEIGHT FOOD CONSUMPTION CHAN6E ACTUAL CHANGE G G/INT G/KG/DAY G/INT 46 146 117.6 28 25 135 104.4 7 28 144 112.1 12 16 139 113.0 7 14 129 109.7 3 10 113 112.8 7 19 126 114.4 6 8 136 115.1 0 11 135 107.4 0 WT. CHG FROM WEEK 19 91 71 88 70 60 43 74 68 74 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 190.0 17.3 121.4 112.1 5.3 69.0 STO. DEV. 23.7 8.3 12.0 7.9 6.2 12.7 BFG 002726 REPRODUCTION STUDY 96-40808 E-63 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BOOT HEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 22 DOSE LEVEL - 1100.0000 PPM FEMALES ANIMAL NO. 4531 4533 4535 4537 4538 4540 4542 4545 4546 4548 4549 4551 4552 4554 4555 4556 4557 4558 4560 4562 4563 HEIGHT G 230 213 196 195 210 228 166 162 181 176 199 216 205 214 199 177 187 164 212 201 187 HEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT 6/KG/DAY G/INT 23 135 103.0 9 20 125 102.6 7 15 118 104.3 4 6 115 99.8 0 18 127 31 137 IQS.3 107.5 9 16 7 113 103.2 3 14 104 111.8 -3 19 109 22 134 IQS.9 135.4 4 14 15 128 111.4 -1 9 134 105.6 3 16 122 103.2 -1 13 128 102.8 5 9 121 103.7 2 16 114 112.4 3 20 117 110.2 4 21 111 106.6 2 17 136 111.4 8 20 123 107.3 12 13 113 104.3 -2 VT. CHG FROM HEEK 19 89 70 70 53 73 95 55 66 63 101 72 77 86 72 66 69 76 77 72 65 60 BFG 002727 REPRODUCTION STUDY 96-4080B E-64 APPENDIX E (cont.) VINYL CHLORIDE COW INED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 22 DOSE LEVEL * 1100.0000 PPM FEMALES ANIMAL NO. 4564 4566 4566 4570 4572 4574 4575 4577 4579 WEIGHT G 171 206 183 191 205 157 182 120 180 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE 6 G/INT G/KG/DAY G/INT 17 120 123.1 IS 17 132 12 118 111.4 111.1 6 6 15 119 108.1 4 18 124 105.4 0 25 110 126.9 6 17 110 105.7 9 IB 91 136.6 -1 19 117 114.4 7 WT. CH6 FROM WEEK 19 68 71 73 56 73 69 61 60 66 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 191.6 16.7 120.2 110.0 5.0 70.8 STD. DEV. 22.4 5.3 10.5 9.1 5.0 10.9 BFG 002728 REPRODUCTION STUDY 96-4080B APPENDuTtcont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK I: 23 DOSE LEVEL - 0.0000 PPM MALES ANIMAL NO. 1031 1032 1033 1035 1037 1039 1041 1043 1045 1047 1048 1052 1054 10S6 1057 lose 1060 1061 1062 1063 1064 WEIGHT G 347 287 376 347 292 317 242 306 339 274 231 330 306 327 320 268 343 343 345 320 335 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/1NT G/KG/DAY G/1NT 37 167 84.7 -1 51 154 98.2 >4 45 186 87.7 -6 40 169 86.1 3 32 155 93.6 -1 37 146 81.5 0 49 135 103.4 9 28 142 81.1 -5 38 175 91.1 4 51 165 110.7 14 41 127 100.5 -3 36 164 87.9 0 33 152 87.5 -8 40 159 86.3 -2 41 157 87.4 6 24 ISO 38 170 97.7 87.4 1 -15 39 177 91.2 0 44 158 61.5 -3 44 156 87,2 4 32 166 86.7 -8 WT. CHG. FROM WEEK 19 175 210 219 203 170 181 167 159 202 206 171 186 173 189 188 159 183 186 208 197 184 BFG 002729 REPRODUCTION STUDY 96-40808 -66 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY HEIGHT AND POOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 23 DOSE LEVEL - 0. 0000 PPM MALES ANIMAL NO. 1066 1068 1070 1071 1072 1074 1076 1078 1WEIGHT G 295 3SS 326 331 352 337 353 369 WEIGHT FOOD CONSIHPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 24 132 77.7 -14 43 165 62.5 -3 42 171 92.8 -4 32 161 85.2 2 31 161 79.7 -17 31 159 82.4 -7 34 167 82.8 -6 48 191 92.3 17 WT. CHG FROM WEEK 19 143 197 202 167 180 165 185 211 NO. OF ANIMALS 29 29 29 29 29 29 MEANS 321.2 38.2 159.9 88.8 -1.6 185.0 STD. DEV. 35.3 7.3 14.6 7.6 7.6 18.4 BFG 002730 REPRODUCTION STUDY 96-4080B -67 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREWTING TREATMENT PERIOD P2 GENERATION WEEK #: 23 DOSE LEVEL - 10. 0000 PPM HALES ANIMAL NO. 2031 2033 2034 2036 2037 2038 2040 2042 2044 2046 2046 2050 2052 2054 2056 2058 2060 2062 2064 2066 2067 WEIGHT G 340 407 351 397 364 310 262 310 329 332 361 279 247 333 350 409 305 332 369 347 356 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G S/INT G/KG/DAY G/INT 37 169 49 184 40 187 87.6 80.2 94.2 7 -7 -4 50 196 87.B 0 39 186 39 163 90.0 93.5 -1 6 33 139 94.4 1 45 165 95.7 -3 27 169 69.3 -13 54 IBS 101.1 11 54 179 89.3 6 44 156 101.2 20 25 126 89.6 -2 39 16Q 85.1 -6 22 171 84.1 -9 39 198 B4.7 -7 31 159 91.5 5 35 164 66.9 -12 36 178 B4.5 -12 35 173 87.5 0 41 173 65.9 5 WT. CHG. FROM WEEK 19 180 225 204 225 211 188 140 202 183 211 211 160 128 185 189 224 162 195 210 190 203 BFG 002731 REPRODUCTION STUDY 96-40808 E-68 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOO - P2 GENERATION WEEK #: 23 DOSE LEVEL - 10.0000 PPM MALES ANIMAL NO. 2068 2070 2072 2073 2074 2075 2076 2077 2078 WEIGHT G 321 327 320 333 339 329 317 362 376 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE 6 G/INT G/KG/DAY G/INT 27 146 41 163 79.1 88.6 -11 -4 41 159 88.5 -2 45 182 97.7 12 46 192 101.3 9 39 171 92.1 -6 29 156 86.0 -12 36 165 36 190 79.9 88.5 -9 -2 WT. CHG. FROM WEEK 19 164 1B2 186 191 200 181 163 190 205 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 337.1 38.5 170.1 89.5 -1.7 189.6 STO. DEV. 37.1 6.0 16.6 5.9 8.2 23.5 BFG 002732 REPRODUCTION STUDY 96-4080B E-69 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMAT1K6 TREATMENT PERIOD - P2 GENERATION WEEK #: 23 DOSE LEVEL - 100.0000 PPM MALES ANIMAL NO. 3031 3032 3033 3034 3035 3037 3039 3041 3042 3043 3045 3046 3047 3048 3049 3050 3051 3052 3055 3057 3056 WEIGHT G 394 376 253 305 288 336 279 233 220 351 320 326 344 376 295 268 290 337 311 297 324 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 44 197 68.3 3 34 181 84.0 -3 31 149 104.6 5 47 178 105.4 5 60 155 100.1 19 32 163 84.9 -4 30 143 90.3 1 39 139 108.5 5 37 136 112.5 15 33 168 83.7 -9 28 164 89.3 -20 17 174 91.3 -27 21 151 SO.5 -13 30 165 76.2 -21 38 144 87.0 -4 31 140 92.4 0 28 147 88.8 -4 37 164 85.8 0 13 145 79.4 -14 39 180 108.1 8 42 269 93.0 1 WT. CHG. FROM WEEK 19 210 193 157 218 186 179 158 168 155 188 171 186 172 181 182 158 142 188 143 176 200 BFG 002733 REPRODUCTION STUDY 96-40806 E-70 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 23 DOSE LEVEL - 100.0000 PPM MALES ANIMAL NO. 30S9 3061 3063 3064 3065 3066 3067 3069 3070 WEIGHT G 3*7 348 365 352 328 303 367 367 320 NO. OF ANIMALS 30 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE 6 G/INT G/KG/DAY G/INT 32 161 81.1 -1 39 162 82.2 -13 22 170 80.0 -6 32 175 86.8 1 31 180 96.0 -11 17 155 47 202 87.7 98.0 -23 2 28 187 86.3 -14 29 170 92.7 -5 30 30 30 30 WT. CHG FROM WEEK 19 181 200 174 188 169 147 221 207 169 30 MEANS STD. DEV. 320.7 42.6 32.9 9.8 164.1 16.9 90.9 9.5 -4.3 10.8 178.9 20.8 BFG 002734 REPRODUCTION STUDY 96-4060B E-71 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TVO-SENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BOOY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK *: 23 DOSE LEVEL - 1100. 0000 PPM MALES ANIMAL NO. 4031 4033 4035 4037 4039 4041 4043 4045 4046 4047 4049 4050 4052 4054 4056 4058 4060 4062 4064 4066 4068 WEIGHT G 362 343 355 375 352 346 288 325 332 324 299 308 355 266 268 299 313 275 357 343 345 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 40 176 86.7 0 41 161 83.2 .4 50 182 91.9 6 34 183 85.2 -5 33 163 Bl.D -6 41 175 69.6 -1 45 160 100.4 11 40 172 94.0 -1 39 176 93.9 -3 30 158 65.2 -9 S3 185 113.1 16 35 166 95.2 -2 28 171 83.6 -17 36 138 92.7 7 23 133 86.4 3 40 163 97.4 2 36 162 91.5 0 35 152 98.4 12 38 172 84.8 1 46 187 97.4 3 37 168 65.6 -3 WT. Cl FROM WEEK : 193 191 220 210 188 199 162 187 193 165 209 174 184 149 127 179 190 164 190 207 182 BFG 002735 REPRODUCTION STUDY 96-4080B E-72 APPENDIX E fcont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND POOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 23 DOSE LEVEL 1100..0000 PPM MALES ANIMAL NO. 4070 *071 4072 4073 4074 4076 4077 4079 4081 1WEIGHT G 356 357 343 350 338 288 269 248 286 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 41 176 87.4 -3 39 180 88.9 -7 37 162 83.2 1 39 170 85.7 1 39 172 90.0 0 46 153 96.2 3 35 136 90.1 13 38 132 96.1 6 46 169 107.5 17 WT. CKG. FROM WEEK 19 206 209 169 181 179 183 136 141 167 NO. OF ANIMALS 30 30 30 30 30 30 MEANS STD. DEV. 322.2 35.3 38.7 6.3 16S.2 15.1 91.4 7.4 1.4 7.4 181.1 22.8 BFG 002736 REPRODUCTION STUDY 96-40808 E-73 APPENDIX E (cont.) VINYL CHLORIOE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 23 DOSE LEVEL FEMALES 0.0000 PPM ANIMAL NO. 1531 1533 1535 1537 1538 1539 1540 1541 1542 1543 1545 1547 1549 1551 1553 1555 1557 1558 1559 1561 1563 WEIGHT G 202 202 219 223 217 225 178 190 208 208 197 1B4 163 246 231 205 209 179 175 197 185 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAT G/INT 22 120 19 124 19 127 104.7 107,4 101.0 10 0 -4 25 124 14 129 25 136 14 111 98.2 102.4 106.7 108.2 24 1 10 -2 8 113 101.3 -7 14 111 13 114 92.0 94.3 2 4 IS no 96.7 -6 19 117 111.7 6 13 no 25 147 19 135 23 127 117.1 104.9 101.6 109.4 -2 13 5 6 25 110 93.3 0 6 107 101.3 2 10 102 100.0 3 19 112 99.6 4 2 101 91.5 -9 WT. CHG FROM WEEK 19 70 127 90 95 99 98 63 64 73 71 92 118 102 106 93 85 92 64 54 90 61 BFG 002737 REPRODUCTION STUDY 96-4080B E-74 APPENOIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOO - P2 GENERATION WEEK #: 23 DOSE LEVEL - 0..0000 PPM FEMALES ANIMAL NO. 1565 1566 1566 1570 1572 1574 1576 1578 1580 1WEIGHT G 213 228 192 237 223 191 221 189 194 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 25 122 101.4 10 19 131 99.9 14 18 109 99.3 2 15 129 93.7 2 41 146 120.2 9 13 113 102.1 3 10 127 98.0 3 10 112 101.4 7 16 107 95.9 4 WT. CHG FROM WEEK 19 93 88 72 100 97 69 67 60 74 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 204.4 17.2 119.4 101.8 3.8 65.6 STD. DEV. 20.1 7.5 12.1 6.B 6.7 17.5 BFG 002738 REPRODUCTION STUDY 96-40808 E-75 APPENOIX (cont.) VINYL CHLORIDE C0H8INE0 INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT ANO FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK#: 23 DOSE LEVEL 10.0000 PPM FEMALES ANIMAL NO. 2S32 2533 2534 2536 2538 2540 2541 2543 2544 2546 2548 2550 2552 2553 2554 2555 2556 2557 2558 2559 2561 WEIGHT G 225 215 239 218 211 207 215 189 207 216 201 173 190 198 225 214 218 219 224 224 193 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 20 126 97.7 4 16 114 91.8 -7 6 131 92.5 -11 19 129 103.1 -2 1 116 91.8 -5 19 117 98.7 -2 16 129 103.9 9 16 120 110.5 -2 30 135 117.2 24 26 126 103.4 -1 12 111 94.9 -1 17 106 109.4 -7 8 108 96.8 -1 -1 84 70.5 -30 13 122 93.1 -2 9 119 15 127 94.7 100.6 -6 -n 1 109 B3.1 -17 19 135 104.9 18 16 139 107.3 3 12 106 94.5 -10 WT. CHG. FROM WEEK 19 89 81 91 93 74 97 83 88 74 97 72 76 65 64 92 74 76 56 63 83 83 BFG 002739 REPRODUCTION STUDY 96-40808 E-76 APPENOIX E (cont.) VINYL CHLORIOE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND POOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 23 OOSE LEVEL - 10. 0000 PPM FEMALES ANIMAL NO. 2563 2566 2567 2569 2571 2573 2575 2577 1HEIGHT G 211 211 192 182 202 196 197 190 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 22 126 106.7 4 10 125 101,1 -3 17 114 103.5 2 1 104 18 118 95.5 101.9 -2 -a 11 128 112.0 -9 11 118 102.7 3 14 143 130.2 28 WT. CHG FROM WEEK 19 89 73 61 58 82 87 60 68 NO. OF ANIMALS 29 29 29 29 29 29 MEANS 207.0 13.6 120.3 100.5 -1.4 77.6 STD. DEV. 15.1 7.4 12.3 10.6 11.4 12.1 BFG 002740 REPRODUCTION STUDY 96-40806 -77 APPENDIX E (eont.) VINYL CHLORIDE COMBINEO INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - 92 GENERATION WEEK #: 23 DOSE LEVEL - 100.0000 PPM FEM4LES ANIMAL NO. 3531 3532 3533 3534 3535 3536 3537 3538 3539 3541 3543 3545 3547 3549 3550 3551 3553 3554 3555 3S56 3557 WEIGHT 6 216 216 162 190 191 169 160 178 183 158 215 184 223 198 184 181 201 233 210 179 194 WEIGHT FOQO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 16 123 98.5 6 15 134 107.1 13 20 117 113.4 4 20 115 106.5 .4 16 123 112.0 6 0 104 102.6 -5 8 102 109.0 4 11 110 106.3 5 10 103 96.4 -7 10 106 115.5 -6 7 122 96.1 8 7 113 104.3 -3 8 117 89.0 -3 15 123 98.9 0 11 108 100.8 -4 13 114 108.9 5 9 103 87.4 -12 10 126 93.6 8 6 121 97.4 -2 14 125 2 110 121.1 95.0 2 -10 WT. CHG FROM WEEK 19 81 82 97 103 87 69 56 68 65 99 85 69 73 95 86 64 63 99 78 67 71 BFG 002741 REPRODUCTION STUDY 96-40608 E-78 APPENOIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 23 DOSE LEVEL - 100.0000 PPM FEMALES ANIMAL NO. 3556 3559 3560 3S62 3564 3565 3566 3567 3566 WEIGHT G 234 244 242 227 209 186 202 220 235 NO. OF ANIMALS 30 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 4 139 99.9 -7 16 134 94.6 -1 14 134 95.0 -10 14 131 99.2 -8 6 123 14 108 99.5 100.6 -6 -S 9 116 97.9 -10 19 138 109.3 2 20 134 99.3 -1 30 30 30 30 WT. CHG. FROM WEEK 19 95 87 102 64 66 57 S3 87 94 30 MEANS STD. DEV. 201.5 24.1 11.5 5.3 118.9 11.3 101.8 7.8 -2.4 6.1 60.5 14.0 BFG 002742 REPRODUCTION STUDY 96-40808 E-79 APPENOIX E (cont.) VINYL CKLORIOE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 23 DOSE LEVEL - 1100.0000 PPM FEMALES ANIMAL NO. 4531 4533 4535 4537 4536 4540 4542 4545 4546 4548 4549 4551 4552 4554 4555 4556 4557 4558 4560 4562 4563 WEIGHT G 240 230 206 201 228 252 202 180 197 207 220 235 222 226 214 iei 203 200 235 216 195 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT 6/KG/DAY G/INT 10 126 89.4 -9 17 124 93.3 -1 12 313 93.2 -5 6 108 90.9 -7 la 126 95.9 -1 24 135 93.8 -2 16 111 95.4 -2 18 101 98.4 -3 16 114 100.5 5 31 132 114.9 -2 21 134 106.6 6 19 132 97.6 -2 17 121 94.5 -1 12 125 94.7 -3 15 121 97.7 0 4 113 105.2 -1 16 121 103,4 4 16 113 98.1 2 23 132 98.4 -4 17 129 102.6 6 8 107 93.4 -6 WT. CHS. FROM WEEK 19 99 87 82 59 91 119 71 64 79 132 93 96 103 84 81 73 92 93 95 82 68 BFG 002743 REPRODUCTION STUDY 96-4060B E-80 APPENDIX E (cont.) VINYL CHLORIDE COHBINEO INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY HEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK f: 23 DOSE LEVEL 1100..0000 PPM FEMALES ANIMAL NO. 4564 4566 4566 4570 4572 4574 4575 4577 4579 WEIGHT G 163 219 205 202 219 172 186 140 196 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 12 125 117.7 5 13 122 95.7 -10 22 117 100.5 -1 11 119 100.9 0 14 126 99.1 2 15 116 117.5 6 6 105 94.6 -5 20 100 128.2 9 16 110 97.5 -7 WT. CHG. FROM WEEK 19 80 84 95 67 87 84 67 80 82 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 207.3 15.5 119.3 100.3 -0.9 66.3 STD. DEV. 23.1 5.6 9.8 6.8 4.8 14.9 BFG 002744 REPRODUCTION STUDY 96-40806 E-Sl APPENOIX E (cont.) VINYL CHLORIDE COWINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD P2 GENERATION WEEK #: 24 DOSE LEVEL - 0. 0000 PPM MALES ANIMAL NO. 1031 1032 1033 1035 1037 1039 1041 1043 1045 1047 1048 1052 10S4 1056 1057 1056 1060 1061 1062 1063 1064 'WEIGHT G 378 331 410 376 309 353 274 334 370 313 272 361 330 360 355 296 373 373 382 354 366 WEIGHT FOOD 'CONSUMPTION CHANGE ACTUAL CHANGE G G/INT 6/KG/DAY G/INT 31 162 74.5 -5 44 160 86.3 6 34 177 75.1 -9 31 166 76.3 -3 17 140 77.6 -15 36 141 70.1 -5 32 141 91.1 6 26 139 72.4 -3 31 173 81.3 -2 39 164 93.1 -1 41 139 92.1 12 31 159 76.7 -5 24 S S S 33 159 77.1 0 35 163 80.5 6 28 145 85.7 -5 30 168 78.2 -2 30 270 79.1 -7 37 161 73.8 3 34 154 76.2 -2 31 165 78.5 -1 WT. CHS FROM WEEK 19 206 254 253 234 187 217 199 187 233 245 212 217 197 222 223 187 213 216 245 231 215 BFG 002745 REPRODUCTION STUDY 96-40000 E-82 APPENDIX E (cont.) VINYL CHLORIDE C0M8INE0 INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CO RATS WEEK #: INDIVIDUAL BODY WEIGHT AND FOOO CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION 24 DOSE LEVEL - 0..0000 PPM MALES ANIMAL NO. 1066 1066 1070 1071 1072 1074 1076 1076 WEIGHT G 312 391 361 345 365 365 376 405 S SPILLAGE WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 17 136 74.7 4 36 164 73.3 -1 33 172 83.2 1 14 145 71.5 -16 33 164 74.2 3 28 164 77.9 5 23 159 72.7 -8 36 169 81.4 -2 WT. CHG. FROM WEEK 19 160 233 235 181 213 193 208 247 NO. OP ANIMALS 29 MEANS 352.1 STD. DEV. 35.5 29 30.9 6.9 26 158.5 13.3 28 78.7 6.2 28 -1.6 6.2 29 216.0 23.4 BFG 002746 REPRODUCTION STUDY 96-4Q80B E-83 APPENOIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD P2 GENERATION WEEK #: 24 DOSE LEVEL - 10.0000 PPM MALES ANIMAL NO. 2031 2033 2034 2036 2037 2036 2040 2042 2044 2046 2048 2050 2052 2054 2056 2056 2060 2062 2064 2066 2067 WEIGHT G 360 447 360 432 405 337 265 306 370 372 405 319 272 362 395 442 344 364 40S 362 397 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 20 156 75.2 -11 40 191 29 160 74.6 82.1 7 -7 35 187 75.2 -9 41 180 78.0 -6 27 ISO 77.3 -13 23 135 82.3 -4 -2 140 75.5 -25 41 173 82.5 4 40 185 87.6 0 44 176 76.6 -3 40 151 84.2 -5 25 123 79.0 -3 29 151 72.4 -9 45 184 82.3 13 33 191 74.8 -7 39 168 66.3 9 32 163 78.1 -1 36 180 77.5 2 35 176 60.5 3 41 177 78.4 4 WT. CHG. FROM WEEK 19 200 265 233 260 252 215 163 200 224 251 255 200 153 214 234 257 201 227 246 225 244 BFG 002747 REPRODUCTION STUDY 96-40608 E-84 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 24 DOSE LEVEL - 10.0000 PPM HALES ANIMAL NO. 2066 2070 2072 2073 2074 2075 2076 2077 2078 WEIGHT G 336 361 353 364 382 357 349 386 407 NO. OF ANIMALS 30 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 15 137 69.5 -9 34 166 80.4 3 33 164 81.2 5 31 175 83.7 -7 43 196 28 174 90.6 84.5 4 3 32 170 85.1 14 24 160 71.3 -5 31 194 82.6 4 30 30 30 30 WT. CHG. FROM WEEK 19 179 216 219 222 243 209 195 214 236 30 MEANS 369.3 32.1 168.5 79.6 -1.6 221.7 STD , OEV. 41.3 9.8 18.7 5.0 6.2 27.8 BFG 002748 REPRODUCTION STUDY 96-40808 E-85 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND POOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 24 DOSE LEVEL 100.0000 PPM MALES ANIMAL NO. 3031 3032 3033 3034 3035 3037 3039 3041 3042 3043 3045 3046 3047 3048 3049 3050 3051 3052 3055 3057 3056 1HEIGHT G 428 405 294 347 329 347 307 283 267 385 342 347 371 406 334 300 316 380 343 322 353 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 34 188 76.2 -9 29 177 75.5 -4 41 156 95.1 7 42 188 96.1 10 41 163 88.1 8 11 160 78.1 -3 28 147 63.6 4 50 169 109.2 30 47 153 104.7 17 34 173 76.4 5 22 166 84.6 4 21 165 81.7 -9 27 160 74.6 -1 30 176 75.0 11 39 153 81.1 9 32 142 83.3 2 26 147 80.9 0 43 179 83.2 15 32 148 75.4 3 25 155 83.5 -25 29 164 60.7 -5 WT. CHG FROM WEEK 19 244 222 198 260 227 190 186 218 202 222 193 207 199 211 221 190 168 231 175 201 229 BFG 002749 REPRODUCTION STUDY 96-4080B E-86 APPENDIX E (cent.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOO CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 24 OOSE LEVEL 100.0000 PPM MALES ANIMAL NO. 3059 3061 3063 3064 3065 3066 3067 3069 3070 WEIGHT G 376 387 399 379 344 327 400 396 345 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 29 154 71.0 -7 39 166 75.3 4 34 177 77.2 7 27 175 79.6 0 16 163 80.9 -17 24 155 82.0 0 33 206 89.5 4 29 176 76.9 -11 25 176 88.2 6 WT. CHG, FROM WEEK 19 210 239 208 215 185 171 254 236 194 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 352.0 31.3 166.0 83.0 1.8 210.2 STD. DEV. 40.2 8.8 14.3 6.7 10.5 23.6 BFG 002750 REPRODUCTION STUDY 96-40606 E-67 APPENDIX E (cent.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOO - P2 GENERATION WEEK /: 24 DOSE LEVEL - 1100.0000 PPM MALES ANIMAL NO. 4031 4033 4035 4037 4039 4041 4043 4045 4046 4047 4049 4050 4052 4054 4056 4058 4060 4062 4064 4066 4068 WEIGHT G 395 378 399 393 377 384 330 345 354 341 342 330 378 306 290 323 351 309 382 375 376 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 33 181 79.7 3 35 170 78.6 9 44 187 82.7 5 18 170 73.8 -13 25 163 74.5 0 38 176 80.4 1 42 162 87.4 2 20 163 81.1 -9 22 161 78.2 -15 17 144 72.2 -14 43 177 92.0 -B 22 159 83.1 -7 23 168 76.4 -3 40 147 85.7 9 22 130 77.7 -3 24 164 87.9 1 38 167 83.8 5 34 148 84.5 -4 25 172 77.6 0 32 181 84.0 -6 31 173 80.0 5 WT. CHG. FROM WEEK 19 226 226 264 228 213 237 204 207 215 182 252 196 207 189 149 203 228 198 215 239 213 BFG 002751 REPRODUCTION STUDY 96-4080B E-ae APPENOIX E {cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS WEEK #: INDIVIDUAL BODY HEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION 24 DOSE LEVEL - 1100..0000 PPM MALES ANIMAL NO. 4070 4071 4072 4073 4074 4076 4077 4079 4061 IWEIGHT G 379 391 375 388 371 325 292 2B1 319 NO. OF ANIMALS 30 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 23 169 76.6 -7 34 161 80.7 1 32 170 78.9 6 38 165 74.5 -S 33 179 84.2 7 37 156 85.9 5 23 142 84.4 6 33 134 84.4 2 33 164 90.4 -5 30 30 30 30 WT. CHG. FROM WEEK 19 229 243 201 219 212 220 159 174 200 30 MEANS STD. DEV. 352.6 35.0 30.5 7.8 164.2 14.1 81.4 4.9 -1.0 6.8 211.6 25.3 BFG 002752 REPRODUCTION STUDY 96-4080B E-69 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOO CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK 4: 24 DOSE LEVEL - 0.0000 PPM FEMALES ANIMAL NO. 1S31 1533 1535 1537 1536 1539 1540 1541 1542 1543 1545 1547 1549 1551 1553 1555 1557 1556 1559 1561 1563 WEIGHT G 220 231 231 232 240 240 197 196 226 221 211 204 175 248 252 225 228 201 192 216 198 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT IB 123 97.2 3 29 131 100.8 7 12 132 97.8 5 9 111 81.3 -13 23 139 101.4 10 15 126 19 120 90.3 106.7 -10 9 6 118 101.9 5 10 105 82.2 -6 13 108 83.9 -6 14 114 93.1 4 20 114 97.9 -3 12 112 110.5 2 2 14B 99.9 1 21 138 95.2 3 20 126 97.7 -1 19 124 94.6 14 22 112 98.2 S 17 100 90.8 -2 19 110 88.8 -2 13 111 96.6 10 WT. CHG FROM WEEK 19 88 156 102 104 122 113 102 70 83 84 106 138 114 108 114 105 111 86 71 109 74 BFG 0D2753 REPRODUCTION STUDY 96-4080B E-90 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND POOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK *: 24 OOSE LEVEL - 0. OOOO PPM FEMALES ANIMAL NO. 1565 1566 1566 1570 1572 1574 1576 1578 1560 WEIGHT G 231 242 207 252 254 209 243 203 211 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 18 118 88.6 -4 14 128 15 108 90.a 90.2 -3 -1 15 127 86.6 -2 31 154 107.6 8 18 122 101.7 9 22 133 95.5 6 14 119 101.2 7 17 112 92.2 S WT. CHG FROM WEEK 19 111 102 87 115 12B 87 109 74 91 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 220.9 16.6 121.4 95.4 2.0 102.1 STD. DEV. 20.5 6.0 12.7 7.2 6.3 19.9 BFG 002754 REPRODUCTION STUDY 96-40808 E-91 APPENDIX E (eont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BOOY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 24 DOSE LEVEL - 10. 0000 PPM FEMALES ANIMAL NO. 2532 2533 2534 2536 2538 2540 2541 2543 2544 2546 2546 2550 2552 2553 2554 2S55 2556 2557 2558 2559 2561 WEIGHT G 254 229 250 232 232 222 227 202 216 232 215 184 199 216 241 232 235 235 239 244 207 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/IHT G/KG/OAY G^INT 29 131 91.2 5 14 119 89.3 5 11 137 93.4 6 14 131 97.0 2 21 119 89.5 3 15 119 92.5 2 12 117 88.2 -12 13 120 102.3 0 9 129 101.7 -6 16 130 96.7 4 14 114 91.3 3 11 136 127.0 28 9 103 88.3 -5 18 100 80.5 16 16 126 90.1 4 18 120 89.7 1 17 138 101.5 11 16 122 89.6 13 15 130 93.6 -5 20 152 108.3 13 14 114 95.0 8 WT. CHG. FROM WEEK 19 118 95 102 107 95 112 95 101 83 113 86 87 74 62 108 92 95 72 78 103 97 BFG 002755 REPRODUCTION STUDY 96-4Q80B E-92 APPENDIX E [cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BOOY HEIGHT AND POOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 24 DOSE LEVEL * 10.0000 PPM FEMALES ANIMAL NO. 2563 2566 2567 2569 2571 2573 2575 2577 WEIGHT G 234 235 208 188 212 214 217 208 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 23 131 24 135 98.1 100.9 3 10 16 112 93.3 -2 6 107 96.4 3 10 109 87.8 9 18 138 112.2 10 20 130 104.7 12 18 119 99.7 -24 WT. CHS. FROM WEEK 19 112 97 77 64 92 105 80 86 NO. OF ANIMALS 29 29 29 29 29 29 MEANS STD. DEV. 222.7 17.4 15.8 4.9 123.7 11.9 96.2 9.1 3.4 9.7 93.4 13.7 BFG 002756 REPRODUCTION STUDY 96-4080B E-93 APPENDIX E (cont.) VINYL CHLORIOE COMBINED INHALATION TNO-GENERATIDN REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS iNorvrouAL boot height ano food consumption PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 24 OOSE LEVEL - 100.0000 PPM FEMALES ANIMAL NO. 3531 3532 3533 3534 3535 3536 3537 3538 3539 3541 3543 3545 3547 3549 3550 3551 3553 3554 3555 3556 3557 WEI6HT G 236 237 201 205 209 195 176 195 200 IBS 233 198 247 219 197 198 211 258 231 191 203 HEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 20 133 98.1 10 21 140 103.0 6 19 121 105.3 4 15 118 99.6 3 18 120 100.0 -3 26 116 106.2 12 16 107 106.2 5 17 111 99.2 1 17 102 88.8 -1 27 118 114.7 12 18 131 97.5 9 14 116 101.2 3 24 124 87.9 7 21 116 92.7 3 13 117 102.4 9 17 119 104.7 5 10 102 82.5 -1 25 136 92.3 a 21 125 94.5 4 12 144 129.7 19 9 116 97.4 6 WT. CHG FROM WEEK 19 101 103 116 118 105 95 72 05 82 126 103 83 97 116 101 81 73 124 99 79 ao BFG 002757 REPRODUCTION STUDY 96-4080B -94 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT ANO FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 24 DOSE LEVEL - 100.0000 PPM FEMALES ANIMAL NO. 3558 3559 3560 3562 3564 3565 3566 3567 3568 WEIGHT G 259 251 25S 235 239 204 215 232 256 NO. OF ANIMALS 30 MEANS 219.1 STD,. DEV. 24.5 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 25 154 104.1 15 7 139 93.6 5 16 135 90.0 1 8 144 103.9 13 30 132 98.2 9 18 111 94.9 3 13 124 99.1 8 12 133 98.1 -5 21 145 98.4 11 30 30 30 30 17.7 125.0 99.5 6.0 5.8 13.3 8.7 5.4 WT. CHG FROM WEEK 19 120 94 118 92 96 75 96 99 115 30 98.1 15.9 BFG 002758 REPRODUCTION STUDY 96-4080B E-95 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 24 DOSE LEVEL - 1100.0000 PPM FEMALES ANIMAL NO. 4531 4533 4535 4537 4538 4540 4542 4545 4546 4548 4549 4551 4552 4554 4555 4556 4557 4558 4560 4562 4563 WEIGHT G 252 239 232 218 245 254 220 191 207 229 237 251 229 239 231 203 218 221 249 228 207 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 12 133 90.1 7 9 122 86.7 -2 24 128 97.0 15 17 108 85.9 0 17 134 94.4 8 12 129 83.3 -6 18 120 94.6 9 11 106 97.0 7 10 104 85.8 -10 22 139 106.3 7 17 139 101.4 5 16 136 93.3 4 7 119 88.0 -Z 13 130 93.2 5 17 12B 95.9 7 22 126 109.4 13 15 124 96.2 3 21 117 92.6 4 14 133 91.6 1 10 122 91.2 -7 12 104 86.2 -3 WT. CHG FROM WEEK 19 111 96 106 76 108 131 89 95 89 154 110 112 110 97 98 95 107 114 109 92 80 BFG 002759 REPRODUCTION STUDY 96-40808 E-96 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BOOT WEIGHT ANO FOOO CONSUMPTION PREMATING TREATMENT PERIOO - P2 GENERATION WEEK #: 24 DOSE LEVEL - 1100. 0000 PPM FEMALES ANIMAL NO. 4564 4566 4568 4570 4572 4574 4575 4577 4579 1HEIGHT G 200 234 232 209 241 192 201 154 205 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 17 117 101.8 -8 15 128 94.2 6 27 128 97.6 11 7 115 93.3 -4 22 135 97.8 9 20 119 109.0 3 13 104 89.1 -1 14 105 119.0 5 9 115 95.6 5 WT. CHG FROM WEEK 19 97 99 122 74 109 104 80 94 91 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 222.6 15.3 122.3 95.3 3.0 101.6 STD. DEV. 22.9 5.1 10.9 7.9 6.2 16.4 BFG 002760 REPRODUCTION STUDY 96-4080B E-97 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BOOY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 25 OOSE LEVEL - 0.0000 PPM MALES ANIMAL NO. 1031 1032 1033 1035 1037 1039 1041 1043 1045 1047 1046 1052 1054 1056 1057 1058 1060 2061 1062 1063 1064 WEIGHT G 406 366 426 410 328 382 297 356 395 331 305 386 364 367 391 309 394 391 404 394 396 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 30 166 35 159 18 165 71.2 76.0 65.6 6 -1 -12 32 157 19 130 29 144 23 136 66.4 66.0 65.3 79.4 -9 -10 3 -5 22 136 65.7 -3 25 165 71.9 -8 18 142 73.5 -22 33 136 78.6 -3 25 159 71.0 0 34 156 74.9 T 27 156 69.6 -3 36 164 73.3 1 13 131 72.2 -14 21 161 70.0 -7 16 154 67.2 -16 22 158 67.0 -3 40 160 30 166 71.3 72.6 6 1 WT. CHG FROM WEEK 19 236 289 271 266 206 246 222 209 258 263 245 242 231 249 259 200 234 234 267 271 245 BFG 00276! REPRODUCTION STUDY 96-40806 -98 APPENDIX E (cent.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATIN6 TREATMENT PERIOO - P2 GENERATION WEEK *: 25 OOSE LEVEL - 0.0000 PPM MALES ANIMAL NO. 1066 1068 1070 1071 1072 1074 1076 1078 WEIGHT G 334 419 388 386 413 387 396 434 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 22 123 63.5 -13 28 159 65.4 -5 27 165 73.4 -7 41 146 66.6 1 28 166 69.3 2 22 157 69.6 -7 20 158 68.2 -1 29 185 73.5 .4 WT. CHG FROM WEEK 19 182 261 262 222 241 215 228 276 T - TECHNICAL PROBLEM NO. OF ANIMALS 29 MEANS 378.6 29 26.4 29 153.9 29 70.4 28 -4.8 29 242.4 STO, DEV. 36.6 6.9 14.0 4.0 6.7 25.2 BFG 002762 REPRODUCTION STUDY 96-4080B -99 APPENOIX (cant.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BOOT WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK /: 25 DOSE LEVEL - 10, 0000 PPM MALES ANIMAL NO. 2051 2033 2034 2036 2037 2038 2040 2042 2044 2046 2046 20S0 2052 2054 2056 2058 2060 2062 2064 2066 2067 WEIGHT G 38S 485 411 474 441 359 313 337 396 404 444 361 286 384 428 482 376 385 430 406 429 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 25 160 71.6 2 38 194 69.4 3 31 171 72.1 -9 42 192 70.6 5 36 177 69.7 -3 22 140 67.0 -10 28 237 76.4 2 29 116 59.9 -24 26 172 74.8 -1 32 179 76.9 -6 39 187 73.4 11 42 159 77.9 8 14 117 69.9 -6 22 156 70.6 7 33 186 75.3 2 40 193 69.6 2 32 166 76.9 -2 21 147 65.4 -16 25 168 67.1 -12 24 159 67.3 -17 32 170 68.6 -7 WT. CHG. FROM WEEK 19 225 303 264 302 286 237 291 229 250 283 294 242 167 236 267 297 233 248 271 249 276 BFG 002763 REPRODUCTION STUDY 96-4080B -100 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT ANO FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK I: 25 DOSE LEVEL - 10.0000 PPM MALES ANIMAL NO. 2068 2070 2072 2073 2074 2075 2076 2077 2078 WEIGHT G 360 389 380 389 408 384 374 405 435 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 24 140 28 167 67.0 74.2 3 1 27 154 70.0 -10 25 170 75.3 -5 26 192 81.0 -4 27 166 74.7 -8 25 168 19 154 77.5 64.9 -2 -6 28 179 70.9 15 WT. CHG. FROM WEEK 19 203 244 246 247 269 236 220 233 264 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 398.0 28.7 164.6 71.5 -3.9 250.5 STD . OEV. 45.2 6.9 20.5 4.7 6.1 32.2 BFG 002764 REPRODUCTION STUDY 96-40808 E-101 APPENDIX E (cant.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS WEEK 4: INDIVIDUAL BODY WEIGHT AND POOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION 25 DOSE LEVEL 100.0000 PPM MALES ANIMAL NO. 3031 3032 3033 3034 3035 3037 3039 3041 3042 3043 3045 3046 3047 3048 3049 3050 3051 3052 3055 3057 3058 WEIGHT G 464 436 329 381 362 378 329 329 310 410 368 378 397 437 373 325 339 418 376 346 390 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 36 188 70.3 0 31 183 35 164 72.5 87.7 6 8 34 183 83.8 -5 33 163 78.6 0 31 153 22 134 70.3 70.2 -7 -13 46 169 92.0 0 43 167 26 169 96.5 70.9 14 -4 26 159 74.6 -9 31 158 26 162 31 172 72.6 70.3 68.0 -7 2 -4 39 154 72.6 1 25 140 74.7 -2 23 139 70.7 -8 38 176 73.5 -3 33 157 72.8 9 24 158 37 166 78.8 74.5 3 2 WT. CHS FROM WEEK 19 2B0 253 233 294 260 221 208 264 245 247 219 238 225 242 260 215 191 269 206 225 266 BFG 002765 REPRODUCTION STUDY 96-4080B E-102 APPENDIX E (cont.) VINYL CHLORIDE COHBINEO INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY HEIGHT AND FOOD CONSUMPTION PREKATING TREATMENT PERIOD - P2 GENERATION WEEK #: 25 DOSE LEVEL - 100.0000 PPM MALES ANIMAL NO. 3059 3061 3063 3064 3065 3066 3067 3069 3070 WEIGHT 6 407 417 426 406 363 359 431 418 370 NO. OF ANIMALS 30 MEANS 382.4 STD. DEV. 39.3 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT 6/KG/DAY G/INT 31 159 67.7 5 30 163 67.6 -3 27 171 69.1 -6 27 172 73.0 -3 19 158 74.5 -5 32 169 82.1 14 31 187 75.0 -19 22 181 74.1 S 25 171 79.7 -5 30 30 30 30 30.4 164.8 75.3 -1.1 6.4 13.2 7.0 7.3 WT. CHG. FROM WEEK 19 241 269 235 242 204 203 285 258 219 30 240.6 26.5 BFG 002766 REPRODUCTION STUDY 96-40808 E-103 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK I: 2S OOSE LEVEL - 1100.0000 PPM MALES ANIMAL NO. 4031 4033 4035 4037 4039 4041 4043 4045 4046 4047 4049 4050 4052 4054 4056 405B 4060 4062 4064 4066 4066 WEIGHT G 427 406 427 427 397 410 354 372 374 361 377 346 402 329 309 348 372 337 414 401 390 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 32 165 75.0 4 30 163 69.1 -7 26 167 67.4 -20 34 173 70.3 3 20 159 68.5 -4 26 158 66.3 -18 24 158 77.0 -4 27 152 70.7 -11 20 151 69.1 -10 20 145 68.9 1 35 169 87.6 12 18 141 69.3 -18 24 172 73.6 4 23 139 73.0 -8 19 128 71.2 -2 25 149 74.0 -15 21 150 69.2 -17 28 147 75.9 -1 32 181 75.8 9 26 167 72.7 -14 14 155 67.4 -16 VT. CHG FROM WEEK 19 25B 256 292 262 233 263 228 234 235 202 287 214 231 212 168 228 249 225 247 265 227 BFG 002767 REPRODUCTION STUDY 96-4080B E-104 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT ANO FOOO CONSUMPTION PREMATING TREATMENT PERI00 - P2 GENERATION WEEK #: 25 DOSE LEVEL - 1100.0000 PPM MALES ANIMAL NO. 4070 4071 4072 4073 4074 4076 4077 4079 4081 WEI6HT G 408 425 400 411 402 340 316 312 353 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 29 165 69.9 -4 34 179 73.1 -2 25 169 72.7 -1 23 164 68.4 -1 31 175 75.5 -4 15 142 71.2 -16 24 136 74.6 -6 31 138 77.6 4 34 162 BO.4 -2 WT. CHG. FROM WEEK 19 258 277 226 242 243 235 183 205 234 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 37B.4 25.7 158.6 72.5 -5.5 237.3 STD . DEV. 36.7 5.B 15.5 4.5 8.6 27.B BFG 002768 REPRODUCTION STUDY 96-40608 E-105 APPENDIX E (cent.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOO CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 25 DOSE LEVEL 0..0000 PPM FEMALES ANIMAL NO. 1531 1533 1535 1537 1538 1539 1540 1541 1542 1543 1545 1547 1549 1551 1553 1555 1557 1558 1559 1561 1563 WEIGHT G 227 257 259 250 245 248 214 215 222 236 232 224 189 267 260 232 223 214 206 221 219 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G 6/INT G/KG/DAY G/INT 7 108 26 127 BO.5 86.7 -15 -4 28 136 92.5 4 18 120 83.0 9 5 117 80.4 -22 8 118 60.6 -8 17 S S S 19 115 93.3 -3 4 102 77.3 -3 15 105 21 112 76.6 84.3 -3 -2 20 109 84.9 -5 14 106 97.1 -6 19 132 as.4 -16 8 121 78.8 -17 7 121 -5 89 88.3 65.a -5 -35 13 102 81.9 -10 14 100 83.8 0 5 105 80.1 -5 21 122 97.S 11 WT. CHS. FROM WEEK 19 95 182 130 122 127 121 119 89 87 99 127 158 128 127 122 112 106 99 85 114 95 BFG 002769 REPRODUCTION STUDY 96-4080B -106 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS INDIVIDUAL BOOT WEIGHT AND POOD CONSUMPTION PREHATING TREATMENT PERIOD - P2 GENERATION WEEK #: 25 DOSE LEVEL 0. 0000 PPM FEMALES ANIMAL NO. 1565 1566 1568 1570 1572 1574 1576 1578 1580 WEIGHT G 241 238 208 267 269 228 253 222 224 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 10 106 .4 112 74.9 77.8 -12 -16 1 101 81.1 -7 15 128 82.2 1 15 125 79.7 -29 19 129 98.4 7 10 127 85.3 -6 19 103 80.8 -16 13 101 77,4 -11 WT. CHG FROM WEEK 19 121 98 88 130 143 106 119 93 104 S - SPILLAGE NO. OF ANIMALS 30 30 29 29 29 30 MEANS 233.7 12.7 113.8 83.3 -7.7 114.9 STD. DEV. 20.3 8.0 11.7 7.2 10.4 21.8 BFG 002770 REPRODUCTION STUDY 96-4080B E-107 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS INDIVIDUAL BODY HEIGHT AND FOOD CONSUMPTION PREMATINS TREATMENT PERIOO - P2 GENERATION WEEK f: 25 OOSE LEVEL - 10.0000 PPM FEMALES ANIMAL NO. 2532 2533 2534 2536 2538 2540 2541 2543 2544 2546 2548 2550 2552 2553 2554 2555 2556 2557 2556 2559 2561 HEIGHT G 259 239 274 244 238 244 231 215 224 253 225 197 207 231 249 246 245 253 253 260 218 HEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHAN6E G G/INT G/KG/DAY G71NT 5 117 76.0 -14 10 112 24 138 79.8 87.8 -7 1 12 129 6 115 22 121 4 120 90.3 81.6 86.6 87.3 -2 -4 2 3 13 126 8 115 100.7 87.1 6 -14 21 135 92.8 5 10 112 B4.8 -2 13 113 98.9 -23 8S S S 15 113 84.3 13 B 117 79.6 -9 14 126 87.9 6 10 132 18 125 91.7 85.4 -6 3 14 121 82.0 -9 16 137 90.6 -15 11 111 87.1 -3 WT. CHG FROM WEEK 19 123 105 126 119 101 134 99 114 91 134 96 100 82 97 116 106 105 90 92 119 108 BFG 002771 REPRODUCTION STUDY 96-40808 E-108 APPENDIX E (cent.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 25 DOSE LEVEL 10.0000 PPM FEMALES ANIMAL NO. 2563 2566 2567 2569 2571 2573 2575 2577 WEIGHT G 250 244 218 206 217 226 226 215 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY 6/INT 16 129 88.8 -2 9 128 89.1 -7 10 114 89.2 2 18 112 94.8 5 5 113 87.6 4 12 135 102.3 -3 9 123 92.6 -7 7 112 88.3 -7 WT. CHG. FROM WEEK 19 126 106 87 82 97 117 89 93 S - SPILLAGE NO. OF ANIMALS 29 MEANS 234.7 29 12.0 28 121.5 28 88.4 28 -3.0 29 105.4 STO. DEV. 18.7 5.2 8.8 6.1 7.9 15.1 BFG 002772 REPRODUCTION STUDY 96-4060B -109 APPENDIX E (contO VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOO CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 25 DOSE LEVEL - IDO.0000 PPM FEMALES ANIMAL NO. 3531 3532 3533 3534 3535 3536 3537 3536 3539 3541 3543 3545 3547 3549 3550 3551 3553 3554 3555 3556 3557 WEIGHT 6 246 243 210 216 219 209 1B7 201 211 196 242 211 246 227 206 202 220 267 242 203 219 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/1NT G/KG/OAY G/INT 10 116 61.6 -15 6 131 91.0 -9 9 123 99.6 2 11 126 99.6 8 10 124 96.6 4 14 123 101.5 7 11 126 115.7 19 6 96 82.5 -13 n 99 80.3 -3 13 114 99.2 -4 9 11S 80.7 -16 13 111 90.5 -5 -1 120 81.1 -4 8 107 9 105 80.0 86.8 -9 -12 4 107 69.2 -12 9 100 77.3 -2 9 130 82.5 -6 11 119 83.9 -6 12 126 106.6 -18 16 120 94.8 4 WT. CHG. FROM WEEK 19 111 109 125 129 115 109 83 91 93 139 112 96 96 124 no 85 82 133 no 91 96 BFG 002773 REPRODUCTION STUDY 96-4080B E-110 APPENOIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT ANO FOOD CONSUMPTION PREMATING TREATMENT PERIOO - PZ GENERATION WEEK #: 25 DOSE LEVEL 100..0000 PPM FEMALES ANIMAL NO. 3558 3559 3560 3562 3564 3565 3566 3567 3566 WEIGHT G 284 266 277 256 247 209 230 246 267 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 25 S S S 17 140 89.9 1 19 142 86.5 7 21 147 99.8 3 8 127 87.1 -5 5 101 81.5 -10 15 115 86.1 -9 14 133 92.7 0 11 140 69.2 -5 WT. CHG FROM WEEK 19 145 111 137 113 104 80 111 113 126 S - SPILLAGE NO. OF ANIMALS 30 30 29 29 29 30 MEANS 230.3 11.2 120.2 90.2 -3.7 109.3 STD. DEV. 26.2 5.2 13.4 9.2 6.4 17.7 BFG 002774 REPRODUCTION STUDY 96-4080B E-lll APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 25 DOSE LEVEL - 1100.0000 PPM FEMALES ANIMAL NO. 4531 4533 4535 4537 4538 4540 4542 4545 4546 4548 4549 4S51 4552 4554 4555 4556 4557 4558 4560 4562 4563 WEIGHT G 264 252 234 217 252 273 229 196 210 241 250 261 246 250 234 219 231 228 261 232 210 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 12 131 84.6 -2 13 126 85.5 4 2 118 84.4 -10 -1 104 79.7 -4 7 119 79.8 -15 9 132 81.9 3 9 115 85.4 -5 5 104 89.6 -4 3 102 81.5 -2 12 135 95.7 -4 13 131 B9.7 -6 10 127 82.7 -9 17 121 84.9 2 11 121 82.5 -9 3 120 86.0 -8 16 125 98.7 -1 13 114 84.6 -10 7 111 82.4 -6 12 135 88.2 2 4 114 82.6 -8 3 102 81.5 -2 WT. CHG. FROM WEEK 19 123 109 108 75 115 140 98 100 92 166 123 122 127 108 101 111 120 121 121 96 83 BFG 002775 REPRODUCTION STUDY 96-4080B E-112 APPENDIX E (cent.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #; 25 DOSE LEVEL - 1100.0000 PPM FEMALES ANIMAL NO. 4564 4566 4568 4570 4572 4574 4575 4577 4579 WEIGHT G 210 235 244 219 256 199 217 167 222 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 10 112 91.1 -5 1 131 93.1 3 12 127 68.9 -1 10 118 91.9 3 17 131 87.5 -4 7 121 103.2 2 16 107 85.3 3 13 103 107.0 -2 17 122 95.2 7 WT. CHG FROM WEEK 19 107 100 134 84 126 111 96 107 106 NO. OF ANIMALS 30 MEANS 232.0 STD. DEV. 23.4 30 30 9.4 119.3 5.1 10.3 30 87.8 6.7 30 -3.0 5.2 30 111.1 18.4 BFG 002776 REPRODUCTION STUDY 96-40806 E-113 APPENDIX E (cont.) VINYL CHLORIDE COMBIHEO INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BOOT WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PER100 - P2 GENERATION WEEK #: 26 DOSE LEVEL 0.0000 PPM MALES ANIMAL NO. 1031 1032 1033 1Q3S 1037 1039 1041 1043 1045 1047 1048 1052 1054 1056 1057 1058 1060 1061 1062 1063 1064 WEIGHT G 427 393 458 431 347 396 311 374 422 363 324 404 391 408 420 322 398 406 416 411 407 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 19 162 64.7 -6 27 161 70.7 2 30 163 61.3 -2 21 152 60.2 -5 19 123 60.7 -7 14 147 63.0 3 14 125 68.5 -11 18 132 60.3 -4 27 171 69.8 6 32 152 73.0 10 19 139 73.7 3 IS 160 67.5 1 27 164 72.4 6 21 161 67.5 5 29 169 69.5 5 13 127 67.1 -4 4 149 62.7 -12 15 158 66.1 4 12 144 58.5 14 17 157 65.0 -3 11 150 62.3 -16 VT. CHG FROM WEEK 19 255 316 301 287 225 260 236 227 285 295 264 260 258 270 288 213 238 249 279 288 256 BFG 002777 REPRODUCTION STUDY 96-40808 -114 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS WEEK f: INDIVIDUAL BODY HEIGHT AND FOOO CONSUMPTION PREMATING TREATMENT PERIOO - PZ GENERATION 26 DOSE LEVEL - 0.0000 PPM MALES ANIMAL NO. 1066 1068 1070 1071 1072 1074 1076 1078 HEIGHT G 351 443 405 408 436 412 418 453 HEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 17 128 62.3 S 24 160 61.9 1 17 170 71.5 5 22 163 68.4 17 23 166 65.2 0 25 165 68.8 8 22 154 63.1 -4 19 181 68.0 -4 WT. CHG. FROM WEEK 19 199 285 279 244 264 240 250 295 NO. OF ANIMALS 29 29 29 29 29 29 MEANS STD. DEV. 398.4 37.8 19.9 6.3 153.6 15.1 66.0 4.2 -0.3 7.5 262.3 27.9 BFG 002778 REPRODUCTION STUDY 96-4060B E-U5 APPENDIX E (cent.) VINYL CHLORIOE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 26 DOSE LEVEL - 10.0000 PPM MALES ANIMAL NO. 2031 2033 2034 2036 2037 2038 2040 2042 2044 2046 2048 2050 2052 2054 2056 2058 2060 2062 2064 2066 2067 WEIGHT G 405 520 436 517 469 360 327 352 417 439 473 384 304 405 454 507 395 412 451 430 446 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 20 151 63.7 -9 35 194 64.3 0 25 172 67.7 1 43 196 65.9 4 28 177 64.6 0 21 135 60.9 -5 14 139 72.4 2 IS 132 63.9 16 21 174 71.3 2 35 176 69.6 -3 29 183 66.5 .4 23 153 68.5 -6 18 124 70.1 7 21 152 64.2 -6 26 183 69.2 -3 25 193 65.0 0 19 ISO 64.9 -16 27 163 68.2 16 21 169 63.9 1 24 152 60.6 -7 17 172 65.5 2 WT. CHS, FROM WEEK 19 245 338 289 345 316 258 205 244 271 318 323 265 285 257 293 322 252 275 292 273 293 BFG 002779 REPRODUCTION STUDY 96-40808 -116 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TUO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY HEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOO - P2 GENERATION WEEK #: 26 DOSE LEVEL - 10.0000 PPM MALES ANIMAL NO. 2068 2070 2072 2073 2074 2075 2076 2077 2078 HEIGHT 6 372 406 402 412 435 406 393 421 455 NO. OF ANIMALS 30 HEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 12 133 60.6 -7 17 155 65.0 -12 22 139 59.2 -15 23 163 67.8 -7 27 182 72.0 -10 22 165 69.6 -1 19 149 64.8 -19 16 144 58.1 -10 20 166 62.2 -13 30 30 30 30 WT. CHG. FROM WEEK 19 215 261 268 270 296 258 239 249 284 30 MEANS STD . DEV. 420.8 49.7 22.8 6.6 161.2 19.7 65.7 3.7 -3.4 8.2 273.3 37.5 BFG 002780 REPRODUCTION STUDY 96-40606 -117 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATIN6 TREATMENT PERIOD - P2 GENERATION WEEK f: 26 DOSE LEVEL - 100.0000 PPM MALES ANIMAL NO. 3031 3032 3033 3034 3035 3037 3039 3041 3042 3043 3045 3046 3047 3048 3049 3050 3051 3052 3055 3057 3058 WEIGHT G 491 466 339 368 389 401 355 369 344 445 384 410 423 459 396 347 356 435 386 382 402 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G 6/1 NT G/KG/DAY G/INT 27 190 66.3 2 30 192 71.0 9 10 147 73.4 -17 -13 134 59.6 -49 27 150 66.6 -13 23 151 64.6 -2 26 142 69.2 8 40 175 83.6 6 34 163 83.1 4 35 177 69.0 8 16 162 71.8 3 32 170 26 154 71.9 62.6 12 -8 22 178 66.2 6 25 154 22 140 66.6 69.4 0 0 17 137 65.7 -2 17 152 10 145 59.4 63.4 -24 -12 36 159 72.8 1 12 158 66.5 -8 WT. CHS. FROM WEEK 19 307 283 243 281 287 244 234 304 279 282 235 270 251 264 2BS 237 208 286 218 261 278 BFG 002781 REPRODUCTION STUDY 96-40808 E-11S APPENDIX E (cont.) VINYL CHLORIDE COMBINEO INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY HEIGHT AND POOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 26 DOSE LEVEL - 100.0000 PPM MALES ANIMAL NO. 3059 3061 3063 3064 3065 3066 3067 3069 3070 WEI6HT G 422 434 444 426 376 385 449 439 369 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 15 147 59.1 -12 17 157 61.5 -6 18 160 61.3 -11 20 165 66.1 -7 13 119 53.7 -39 26 161 18 177 72.1 67.0 -8 -10 21 172 66.9 -9 19 169 74.2 -2 WT. CHG FROM WEEK 19 256 286 253 262 217 229 303 279 238 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 403.8 21.4 158.6 67.S -6.3 262.0 STD . DEV. 39.5 10.2 16.5 6.5 13.3 27.2 BFG 002782 REPRODUCTION STUDY 96-408QB -119 APPENDIX E (cant.) VINYL CHLORIDE COWINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS WEEK t: INDIVIDUAL BODY HEIGHT ANO FOOD CONSUMPTION PREMATING TREATMENT PERIOO - P2 GENERATION 26 DOSE LEVEL - UOO..0000 PPM MALES ANIMAL NO. 4031 4033 4035 4037 4039 4041 4043 4045 4046 4047 4049 4050 4052 4054 4056 4058 4060 4062 4064 4066 4068 HEIGHT G 451 429 458 455 422 433 385 397 399 389 410 376 418 355 325 379 400 357 432 427 425 HEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 24 176 66.8 -9 23 153 60.9 -10 31 175 65.9 8 26 172 65.0 -l 25 167 68.0 8 23 168 66.4 10 31 167 75.3 9 25 157 68.1 5 25 159 68.6 8 28 142 63.1 -3 33 175 74.1 -14 28 154 70.9 13 16 162 65.9 -10 26 142 69.2 3 16 125 65.7 -3 31 155 71.1 6 28 166 71.7 16 20 152 73.0 5 18 165 65.0 -16 26 176 70.9 9 35 171 69.9 16 VT. CKG FROM WEEK 19 282 277 323 290 258 286 259 259 260 230 320 242 247 238 184 2S9 277 246 265 291 262 BFG 002783 REPRODUCTION STUDY 96-4080B E-120 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOO CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 26 DOSE LEVEL 1100.0000 PPM MALES ANIMAL NO. 4070 4071 4072 4073 4074 4076 4077 4079 4081 WEIGHT G 427 447 426 432 421 370 340 331 376 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/1NT G/KG/DAY G/INT 19 157 62.7 -8 22 176 67.3 -3 26 154 62.1 -15 21 159 62.9 -5 19 154 62.4 -21 30 160 75.1 IB 24 126 64.0 -10 19 130 67.4 -8 23 168 76.8 6 WT. CHG. FROM WEEK 19 277 299 252 263 262 265 207 224 257 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 403.1 24.7 158.8 67.9 0.1 262.0 STD . DEV. 37.0 6.0 14.3 4.3 10.6 29.3 BFG 002784 REPRODUCTION STUDY 96*40809 E-121 APPENDIX E (cent.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT ANO FOOO CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 26 OOSE LEVEL - 0.0000 PPM FEMALES ANIMAL NO. 1531 1533 1535 1537 1538 1539 1540 1541 1542 1543 1545 1547 1549 1551 1553 1555 1557 1558 1559 1561 1563 WEIGHT S 225 270 262 273 269 269 231 230 239 242 244 245 211 271 266 250 232 225 215 238 239 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT -2 106 79.6 0 13 127 80.3 0 3 132 84.5 -4 23 131 63.5 11 24 135 87.5 16 21 137 88.3 19 17 US 86.1 T IS 119 89.1 4 17 107 77.4 S 6 110 76.7 5 12 122 85.4 10 21 128 91.0 19 22 117 97.5 11 4 133 82.4 1 6 121 76.7 0 18 127 87.8 6 9 101 74.0 12 11 110 83.5 8 9 96 77.6 -2 17 113 82.1 8 20 129 93.9 7 WT. CHG. FROM WEEK 19 93 195 133 145 151 142 136 104 104 105 139 179 150 131 128 130 115 110 94 131 115 BFG 002785 REPRODUCTION STUDY 96-408QB E-122 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 26 DOSE LEVEL 0..0000 PPM FEMALES ANIMAL NO. 1S65 1566 I56S 1570 1572 1574 1576 1578 1580 WEIGHT G 255 260 229 276 274 242 266 227 231 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 14 115 77.3 9 22 126 84.3 14 21 110 83.9 9 9 130 79.8 2 5 132 81.0 7 14 126 89.4 -3 13 137 88.0 10 5 106 78.7 3 7 100 73.3 -1 WT. CHG FROM WEEK 19 135 120 109 139 148 120 132 98 111 T TECHNICAL PROBLEM NO. OF ANIMALS 30 30 30 30 29 30 MEANS 246.9 13.2 120.1 83.4 6.5 126.1 STD. DEV. 19.3 7.0 11.7 5.8 6-4 23.3 BFG 002786 REPRODUCTION STUDY 96-4080B E-123 APPEN01X (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND POOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK : 26 DOSE LEVEL - 10.0000 PPM PEMALES ANIMAL NO. 2532 2533 2534 2536 2538 2540 2541 2543 2544 2546 2548 2550 2552 2553 2S54 2555 2556 2557 2558 2559 2561 WEIGHT G 267 251 302 264 249 252 249 232 240 266 238 204 221 238 256 252 256 260 262 269 228 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 6 119 75.4 2 12 113 76.9 1 28 144 83.3 6 20 133 87.3 4 11 114 78.0 -1 8 122 82.0 1 18 132 91.7 12 17 130 96.9 4 16 123 88.4 8 13 136 67.3 1 13 113 81.4 1 7 117 97.3 4 14 110 85.7 T 7 106 75.3 -7 7 112 73.9 -5 6 121 81.0 -5 13 143 94.6 11 7 112 72.8 -13 9 132 65.4 11 9 136 85.7 -1 10 107 80.0 -4 WT. CHG FROM WEEK 19 131 117 154 139 112 142 117 131 107 147 109 107 96 104 123 112 118 97 101 128 118 BFG 002787 REPRODUCTION STUDY 96-40806 -124 APPENDIX E (eont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT ANO FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 26 DOSE LEVEL - 10.0000 PPM FEMALES ANIMAL NO. 2S63 2566 2567 2569 2571 2573 2575 2577 WEIGHT G 265 255 226 224 236 238 241 221 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 15 127 82.2 -2 11 120 80.2 -8 8 112 84.1 -2 18 110 85.3 -2 19 124 91.2 11 12 130 93.4 -5 15 124 88.5 1 6 112 85.6 0 WT. CHG. FROM WEEK 19 143 117 95 100 116 129 104 99 T - TECHNICAL PROBLEM NO. OF ANIMALS 29 MEANS 247.0 STD. DEV. 19.7 29 12.3 5.2 29 121.9 10.7 29 84.S 6.7 28 0.8 6.2 29 117.7 16.5 BFG 002788 REPRODUCTION STUDY 96-40806 -125 APPENDIX E (cont.) VINYL CHLORIDE COWIKED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BOOY WEIGHT AND FOOO CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 26 DOSE LEVEL - 100..0000 PPM FEMALES ANIMAL NO. 3531 3532 3533 3534 3535 3536 3537 3538 3539 3541 3543 3545 3547 3549 3550 3551 3553 3554 3555 3556 3557 WEIGHT G 256 261 232 235 235 229 192 214 233 214 257 219 268 241 227 212 236 280 252 214 225 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 10 119 79.0 1 18 127 84.0 -4 22 130 98.0 7 19 128 94.6 2 16 133 20 119 97.7 90.6 9 -4 5 100 88.0 -26 13 113 90.8 15 22 111 16 127 83.3 102.8 12 13 15 122 61.5 7 8 117 90.7 6 22 117 14 121 75.9 86.2 -3 14 21 124 95.5 19 10 105 84.5 -2 16 106 77.5 6 13 127 77.4 -3 10 114 76.9 -5 11 124 6 108 99.1 81.1 -2 -12 WT. CHG. FROM WEEK 19 121 127 147 148 131 129 88 104 115 155 127 104 118 138 131 95 98 146 120 102 102 BFG 002789 REPRODUCTION STUDY 96-40808 E-126 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD P2 GENERATION WEEK t: 26 OOSE LEVEL 100.0000 PPM FEMALES ANIMAL NO. 35S8 3559 3560 3562 3564 3565 3566 3567 3566 WEIGHT G 294 289 290 274 254 214 245 260 167 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 10 145 83.6 T 21 151 90.4 11 13 135 79.4 -7 18 143 89.9 -4 7 120 79.8 -7 5 112 88.3 11 15 119 83.5 4 14 138 90.9 5 -80 5 3.7 -135 T TECHNICAL PROBLEM VT. CHG. FROM WEEK 19 155 132 150 131 111 85 126 127 46 NO. OF ANIMALS 30 30 30 30 29 30 MEANS 241.3 11.0 118.7 84.1 -2.5 120.3 STD,. DEV. 28.0 18.0 24.6 16.9 27.2 24.0 BFG 002790 REPRODUCTION STUDY 96-4080B E-1Z7 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND POOD CONSUMPTION PREMATING TREATMENT PERIOO - P2 GENERATION WEEK #: 26 DOSE LEVEL 1100.,0000 PPM FEMALES ANIMAL NO. 4S31 4533 4535 4537 4536 4540 4542 4545 4546 4548 4549 4551 4552 4554 4555 4556 4557 4556 4560 4562 4563 WEIGHT G 275 274 247 227 255 291 240 206 226 256 264 281 260 263 246 235 244 242 269 243 219 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G 6/1NT G/KG/DAY G/INT 11 129 79.8 -2 22 129 81.7 3 13 119 82.5 1 10 102 76.6 -2 3 106 71.0 -11 18 146 66.3 14 11 110 7B.2 -5 10 93 77.1 -11 16 100 76.1 -2 17 127 84.8 -a 14 128 83.0 -3 20 124 76.3 -3 14 127 83.7 6 13 122 79.3 1 12 120 83.3 0 16 125 91.8 0 13 115 80.7 1 14 112 79.4 l 8 120 75.5 -IS 11 202 71.6 -12 9 105 81.6 3 WT. CHG. FROM WEEK 19 134 131 121 85 118 158 109 110 110 183 137 142 141 121 113 127 133 135 129 107 92 BFG 002791 REPRODUCTION STUDY 96-4080B -128 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND POOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 26 DOSE LEVEL - 1100.0000 PPM FEMALES ANIMAL NO. 4564 4566 4666 4570 4572 4574 4575 4577 4579 1HEIGHT G 217 260 252 230 269 215 233 162 242 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 7 102 79.6 -10 25 141 8 121 94.9 81.3 10 -6 11 118 87.6 0 11 124 16 112 16 107 78.4 90.2 79.3 -7 -9 0 15 105 100.3 2 20 123 88.4 1 WT. CHG FROM WEEK 19 114 125 142 95 137 127 112 122 128 NO. OF ANIMALS 30 30 30 30 30 30 MEANS STO. DEV. 245.6 24.0 13.5 4.B 117.2 12.3 82.0 6.5 -2.1 6.5 124.6 19.5 BFG 002792 REPRODUCTION STUDY 96-4080B E-129 APPENDIX E (cont.) VINYL CHLORIDE COMBINEO INHALATION TVO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND POOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 27 DOSE LEVEL - 0..0000 PPM KALES ANIMAL NO. 1031 1032 1033 103S 1037 1039 1041 1043 1045 1047 1048 1052 1054 1056 1057 1058 1060 1061 1062 1063 1064 WEIGHT G 436 409 479 445 3S8 401 321 390 428 377 334 415 396 421 436 331 425 415 416 422 421 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 9 154 59.5 -8 16 147 61.1 -14 21 160 56.9 -3 14 154 58.6 2 11 128 60.5 5 5 135 56.5 -12 10 117 61.7 -8 16 137 59.8 5 6 164 64.3 -7 14 150 67.6 -2 10 129 65.3 -10 11 258 64.3 -2 5 139 58.9 -25 13 160 64.3 -1 16 159 61.9 -10 9 126 64.3 -1 27 164 66.4 15 9 152 61.7 -6 0 136 54.5 -6 11 149 59.6 -e 14 164 66.0 14 WT. CHG. FROM WEEK 19 264 332 322 301 236 265 246 243 291 309 274 271 263 283 304 222 265 258 279 299 270 BFG 002793 REPRODUCTION STUDY 96-4080B E-130 APPENDIX E (cont.) VINYL CHLORIOE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOO - PZ GENERATION WEEK #: 27 DOSE LEVEL - 0..0000 PPM MALES ANIMAL NO. 1066 1068 1070 1071 1072 1074 1076 1078 WEIGHT G 364 458 408 424 446 418 421 462 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY 6/INT 13 133 62.0 5 15 157 58.1 -3 3 149 61.1 -21 16 166 67.3 5 10 150 56.7 -16 6 151 60.6 -14 3 141 56.0 -13 9 167 60.8 -14 NT. CHG. FROM WEEK 19 212 300 282 260 274 246 253 304 NO. OF ANIMALS 29 29 29 29 29 29 MEANS STD. DEV. 409.6 38.5 11.1 5.7 148.2 13.7 61.3 3.5 -5.3 9.4 273.4 28.7 BFG 002794 REPRODUCTION STUDY 96-4080B -131 APPENDIX (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT ANO FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 27 DOSE LEVEL - 10.0000 PPM MALES ANIMAL NO. 2031 2033 2034 2036 2037 2038 2040 2042 2044 2046 2048 2050 2052 2054 2056 2058 2060 2062 2064 2066 2067 WEIGHT G 419 547 454 534 476 397 342 392 424 452 481 407 315 424 463 511 40S 435 473 439 457 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 14 148 59.9 -3 27 167 58.4 -7 18 172 64.4 0 17 192 7 167 60.9 58.9 -4 -10 17 136 58.3 1 15 126 62.8 -13 40 146 65.4 14 7 155 61.4 -19 13 172 64.3 -4 8 171 59.7 -12 23 154 64.9 1 11 128 68.9 4 19 148 59.5 -4 9 162 56.9 -21 4 176 10 150 57.6 62.5 -17 0 23 159 62.6 -4 22 170 61.3 1 9 158 60.6 6 11 163 60.2 -9 WT. CHS FROM WEEK 19 259 365 307 362 323 275 220 284 278 331 331 2B8 196 276 302 326 262 298 314 282 304 BFG 002795 REPRODUCTION STUDY 96-40606 E-132 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 27 DOSE LEVEL - 10.0000 PPM MALES ANIMAL NO. 2068 2070 2072 2073 2074 207S 2076 2077 2078 WEIGHT G 394 432 433 437 452 422 417 433 476 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 22 151 65.7 18 26 175 69.6 20 31 155 61.9 16 25 181 71.1 18 17 184 16 165 69.1 66.4 2 0 24 164 67.5 15 12 153 59.7 9 21 186 66.6 20 WT. CHG. FROM WEEK 19 237 287 299 295 313 274 263 261 305 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 438.1 17.3 161.8 63.0 0.6 290.6 STD. DEV. 48.3 8.1 16.6 3.8 11.7 36.9 BFG 002796 REPRODUCTION STUDY 96-4080B E-133 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 27 DOSE LEVEL 100.0000 PPM MALES ANIMAL NO. 3031 3032 3033 3034 3035 3037 3039 3041 3042 3043 3045 3046 3047 3048 3049 3050 3051 3052 3055 3057 3056 WEIGHT G 507 490 356 378 413 423 370 386 373 4S1 397 419 437 486 419 371 364 463 407 409 413 WEIGHT FOOD CONSUMPTION CHANGE actual CHANGE G G/1NT G/KG/DAY G/INT 16 174 58.1 >16 24 190 66.2 -2 17 T T T 10 122 54.5 -12 24 164 68.2 14 22 153 61.9 2 15 136 62.5 >6 17 151 66.7 24 29 165 76.7 2 6 158 58.8 -19 13 147 62.7 -15 9 158 63.5 -12 14 146 56.6 -8 27 192 21 150 67.7 61.2 14 -4 24 144 66.9 4 8 142 28 170 65.7 63.1 5 18 21 159 66.8 14 27 167 70.4 8 11 154 63.0 -4 WT. CHG. FROM WEEK 19 323 307 260 291 311 266 249 321 308 288 248 279 265 291 306 261 216 314 239 2SB 289 BFG 002797 REPRODUCTION STUDY 96-4080B 134 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS INDIVIDUAL BODY WEIGHT ANO FOOO CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 27 DOSE LEVEL - 100.0000 PPM MALES ANIMAL NO. 3059 3061 3063 3064 3065 3066 3067 3069 3070 WEIGHT G 430 444 456 444 406 404 470 458 406 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G 6/INT G/KG/OAY G/INT 8 140 54.8 -7 10 152 57.7 -5 12 157 58.1 -3 18 163 62.5 -2 30 171 19 160 72.9 67.6 52 -1 21 169 61.3 8 19 S S S 17 S S S WT. CHG. FROM WEEK 19 264 296 265 280 247 248 324 298 255 T TECHNICAL. PROBLEM S SPILLAGE NO. OF ANIMALS 30 30 27 27 27 30 MEANS 421.7 17.9 157.6 63.6 -0.6 279.9 STD. DEV. 39.5 6.9 15.3 5.4 14.8 28.1 BFG 002798 REPRODUCTION STUDY 96-4080B E-135 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 27 DOSE LEVEL - 1100..0000 PPM HALES ANIMAL NO. 4031 4033 403S 4037 4039 4041 4043 4045 4046 4047 4049 4050 4052 4054 4056 4058 4060 4062 4064 4066 4068 WEIGHT G <74 441 483 473 446 454 412 414 426 409 425 411 443 378 336 397 419 382 443 446 442 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 23 187 67.4 11 12 157 60.2 4 25 177 62.7 2 18 180 64.7 B 24 163 62.6 -4 21 170 63.9 2 27 171 71.5 4 17 154 63.3 -3 27 167 67.5 8 20 141 58.9 -1 15 167 66.7 -8 35 165 69.9 11 25 166 64.3 4 23 148 67.3 6 11 125 63.0 0 18 152 65.3 -3 19 168 68.4 Z 25 152 68.6 0 11 168 64.0 3 19 172 65.7 -4 17 170 65.4 -1 WT. CHG. FROM WEEK 19 305 289 348 308 2B2 307 286 276 287 250 335 277 272 261 195 277 296 271 276 310 279 BFG 002799 REPRODUCTION STUDY 96-40B0B E-136 APPENDIX E (cont.J VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 27 DOSE LEVEL - 1100.0000 PPM MALES ANIMAL NO. 4070 4071 4072 4073 4074 4076 4077 4079 4061 WEIGHT G 446 462 436 440 436 391 355 351 396 NO. OF ANIMALS 30 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/K6/DAY G/INT 19 164 62.6 7 15 167 61.2 -9 10 155 59.9 1 6 160 61.2 1 15 167 65.0 13 21 154 67.5 -6 15 133 63.8 7 20 138 67.4 8 20 171 73.8 3 30 30 30 30 WT. CHG. FROM WEEK 19 296 314 262 271 277 286 222 244 277 30 MEANS 422.2 19.2 161.0 65.1 2.2 2B1.2 STD. DEV. 36.6 5.9 13.9 3.4 5.6 30.1 BFG 002800 REPRODUCTION STUDY 96-40806 E-137 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPROOXTION AND DEVELOPMENTAL TOXICITY STUOY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PZ GENERATION WEEK #: 27 DOSE LEVEL > 0..0000 PPM FEMALES ANIMAL NO. 1531 1533 1535 1537 1538 1539 1540 1541 1542 1543 1545 1547 1549 1551 1553 1555 1557 1558 1559 1561 1563 WEIGHT G 239 273 278 276 271 281 237 230 244 258 258 260 227 276 275 262 244 229 215 253 237 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 14 110 79.0 2 3 111 68.1 -16 16 116 71.6 -16 3 114 69.2 -17 2 124 76.5 -11 12 121 73.3 -16 6 102 72.6 -13 0 111 80.4 -8 5 101 69.7 -6 16 106 70.7 -4 14 121 80.3 -1 IS 127 83.8 -1 16 120 91.3 3 5 113 68.9 -20 9 123 75.8 2 12 121 7S.8 -6 12 HO 77.0 9 4 101 74.2 -9 0 88 66.2 -10 15 110 74.7 -3 -2 S S S WT. CHG. FROM WEEK 19 107 198 149 148 153 154 142 104 109 121 153 194 166 136 137 142 127 114 94 146 113 BFG 002801 REPRODUCTION STUDY 96-4080B -138 APPENDIX E (cont.j VINYL CHLORIDE COMBINED INHALATION TVO-GENERATIQN REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BOOT HEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 27 OOSE LEVEL - 0. 0000 PPM FEMALES ANIMAL NO- 1565 1566 1568 1570 1572 1574 1576 1578 1580 HEIGHT G 270 267 237 287 276 247 274 238 239 HEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 15 117 74.3 2 7 126 79.7 0 8 113 80.8 3 11 124 73.4 -6 2 123 74.5 -9 5 110 75.0 -16 B 122 75.3 -15 11 102 73.1 -4 6 101 71.6 1 WT. CHG FROM WEEK 19 150 127 117 150 150 125 140 109 119 S - SPILLAGE NO. OF ANIMALS 30 30 29 29 29 30 MEANS 255.3 8.4 113.4 75.2 -6.4 136.5 STD. DEV. 19.6 S.5 9.5 5.2 7.6 24.5 BFG 002802 REPRODUCTION STUDY APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT ANO FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 27 DOSE LEVEL - 10.0000 PPM FEMALES ANIMAL NO. 2532 2533 2534 2536 2538 2540 2541 2543 2544 2546 2548 2550 2552 2553 2554 2555 2556 2557 2556 2559 2561 WEIGHT G 270 256 291 268 257 263 256 244 244 273 243 220 226 246 267 278 264 265 263 274 235 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 3S S S S 104 68.4 -9 -a 124 69.7 -20 4 132 82.7 -1 8 111 73.1 -3 11 119 77.0 -3 7 114 75.2 18 12 130 91.0 0 4 114 7 124 78.5 76.7 -9 -12 5 102 70.7 -11 16 S S S 5 103 76.8 -7 8 102 70.2 -4 n 122 77.8 10 26 142 89.3 21 6 129 82.4 -14 5 127 80.6 15 l 117 74.3 -15 5 122 7 100 74.9 72.0 -14 -7 WT. CHG FROM WEEK 19 134 122 143 143 120 153 124 143 111 154 114 123 101 112 134 138 124 102 102 133 125 BFG 002803 REPRODUCTION STUDY 96-40BQB -140 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BOOY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 27 DOSE LEVEL - 10.0000 PPM FEMALES ANIMAL NO. 2563 2566 2567 2569 2571 2573 2575 2577 WEIGHT G 2B9 265 236 226 245 249 251 232 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 24 131 7B.8 4 10 130 83.3 10 10 110 79.4 -2 2 103 76.3 -7 9 120 83.2 -4 11 134 91.7 4 10 133 90.1 9 11 111 81.7 -1 WT. CHG FROM WEEK 19 167 127 105 102 125 140 114 110 S - SPILLAGE NO. OF ANIMALS 29 29 27 27 27 29 MEANS 255.0 8.0 118.9 78.7 -3.3 125.7 STD. DEV. IB.4 6.7 11.9 6.5 10.1 17.3 BFG 002804 REPRODUCTION STUDY 96-4080B E-141 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 27 DOSE LEVEL - 100.0000 PPM FEMALES ANIMAL NO. 3531 3532 3533 3534 3535 3536 3537 3538 3539 3541 3543 3545 3547 3549 3550 3551 3553 3554 3555 3556 3557 WEIGHT G 270 277 257 253 246 227 202 222 230 231 265 231 258 246 233 219 239 293 252 215 237 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 14 125 79.2 6 16 145 69.8 18 25 140 95.4 10 18 117 79.9 11 11 S S S -2 115 84.1 -4 10 122 103.2 22 8 107 81.8 -6 -3 109 78.5 -2 17 119 89.1 -8 8 126 80.5 4 12 114 84.4 -3 -10 93 58.9 -24 5 107 73.2 -14 6 116 64.1 -8 7 100 77.3 -5 3 98 68.6 -8 13 114 66.3 -13 0 113 74.7 -1 1 102 79.3 -22 12 119 85.9 11 VT. CHG FROM WEEK 19 135 143 172 166 142 127 98 112 112 172 135 116 108 143 137 102 101 159 120 103 114 BFG 002805 REPRODUCTION STUDY 96-4080B E-142 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD PZ GENERATION WEEK #: 27 DOSE LEVEL 100.0000 PPM FEMALES ANIMAL NO. 3556 3559 3560 3562 3564 3565 3566 3567 3568 WEIGHT G 266 291 266 276 250 226 246 270 206 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 6 150 85.9 5 2 131 75.3 -20 -2 106 61.1 -29 2 130 76.6 -13 -4 121 80.0 1 12 106 80.3 -6 1 116 78.6 -3 10 129 19 95 81.1 80.6 -9 90 WT. CHG FROM WEEK 19 149 134 148 133 107 97 127 137 65 S - SPILLAGE NO. OF ANIMALS 30 30 29 29 29 30 MEANS 248.1 6.8 116.7 79.9 -1.4 127.1 STO. OEV. 25.6 8.3 14.1 9.1 21.1 24.7 BFG 002806 REPRODUCTION STUDY 96-4080B E-143 APPENDIX E (cent.) VINYL CHLORIDE COWINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT ANO FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 27 DOSE LEVEL - 1100.0000 PPM FEMALES ANIMAL NO. 4531 4533 4535 4537 4538 4540 4542 4545 4546 4548 4549 4551 4552 4554 4555 4556 4557 4558 4560 4562 4563 WEIGHT G 276 285 253 243 265 305 246 213 233 259 261 286 266 268 250 225 242 246 275 246 224 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 1 124 75.0 -5 11 130 6 114 77.5 76.0 1 -5 16 109 77.3 7 10 130 14 142 83.3 79.4 22 -4 6 117 80.2 7 7 98 S 108 78.0 78.1 5 8 1 131 84.5 4 -3 128 81.3 0 5 126 75.2 4 6 121 76.7 -6 5 128 4 118 80.4 79.3 6 -2 -10 114 82.6 -11 -2 109 4 108 6 127 74.8 73.8 77.8 -6 4 7 3 113 77.0 11 5 99 74.5 -6 WT. CHS. FROM WEEK 19 135 142 127 101 128 172 115 117 115 184 134 147 147 126 117 117 131 139 135 110 97 BFG 002807 REPRODUCTION STUDY 96-40808 E-144 APPENDIX E (cont.) VINYL CHLORIOE COMBINEO INHALATION TWO-SENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATINS TREATMENT PERIOD - P2 GENERATION WEEK #: 27 DOSE LEVEL - 1100. 0000 PPM FEMALES ANIMAL NO. 4564 4566 4568 4570 4572 4574 457S 4577 4579 1WEIGHT G 213 269 261 233 272 225 234 192 247 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT -4 102 79.1 0 9 136 85.7 5 9 117 76.0 -4 3 108 77.8 -10 3 120 73.9 -4 10 109 82.6 -3 1 102 72.8 -5 10 101 90.0 -4 5 114 77.7 -9 WT. CHG. FROM WEEK 19 110 134 151 98 140 137 113 132 133 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 250.4 4.9 116.8 78.6 -0.4 129.5 STD. DEV. 24.8 5.4 11.6 3.9 7.2 19.6 BFG 002808 REPRODUCTION STUDY 96-40806 E-145 APPCNOIX E (cont.) VINYL CHL0R10E COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOO CONSUMPTION PREMATING TREATMENT PERIOO - P2 GENERATION WEEK #: 28 DOSE LEVEL - 0.0000 PPM MALES ANIMAL NO. 1031 1032 1033 103S 1037 1039 1041 1043 1045 1047 1046 1052 1054 1056 1057 1058 1060 1061 1062 1063 1064 WEIGHT G 466 435 509 468 383 422 338 407 450 394 351 423 415 435 447 344 434 434 439 445 445 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/IWT G/KG/OAY G/INT 30 170 62.8 16 26 166 65.6 19 30 189 63.8 29 23 166 60.6 12 25 135 60.7 7 21 147 59.5 12 17 132 66.8 15 17 148 61.9 11 22 168 63.8 4 17 153 66.1 3 17 148 72.0 19 8 155 61.7 -3 19 S S S 14 160 62.3 0 11 176 66.4 17 13 137 67.7 11 9 154 59.8 -10 19 159 62.4 7 23 164 63.9 ZB 23 146 56.1 -3 24 169 65.1 5 WT. CHG. FROM WEEK 19 294 358 352 324 261 286 263 260 313 326 291 279 282 297 315 235 274 277 302 322 294 BFG 002809 REPRODUCTION STUDY 96-40808 E-146 APPENDIX E (cont.) VINYL CHLORIDE COWINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOO - P2 GENERATION WEEK #: 28 DOSE LEVEL - 0..0000 PPM MALES ANIMAL NO. 1066 1066 1070 1071 1072 1074 1076 1078 WEIGHT G 377 473 431 445 470 433 444 488 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/1NT G/KG/DAY G/INT 13 135 60.7 2 15 162 58.0 5 23 172 68.3 23 21 174 66.7 6 24 186 67.7 36 15 165 64.6 14 23 167 64.4 26 26 189 66.3 22 WT. CHG FROM WEEK 19 225 315 30S 281 298 261 276 330 S - SPILLAGE NO. OF ANIMALS 29 29 28 28 28 29 MEANS 429.1 19.6 160.4 63.8 11.9 293.0 STD. OEV. 40.9 5.8 15.7 3.5 10.9 31.1 BFG 002810 REPRODUCTION STUDY 96*40808 E-147 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BOOT WEIGHT AND FOOO CONSUMPTION PREMATING TREATMENT PERIOD P2 GENERATION WEEK #: 28 DOSE LEVEL - 10..0000 PPM MALES ANIMAL NO. 2031 2033 2034 2036 2037 2038 2040 2042 2044 2046 2048 2050 2052 2054 2056 2058 2060 2062 2064 2066 2067 WEIGHT G 439 560 456 553 487 413 351 370 439 462 494 422 332 443 492 538 432 455 500 377 483 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 20 156 60.6 8 13 176 53.0 -11 2 165 60.4 -7 19 199 61.0 7 11 154 53.3 -13 16 147 60.5 11 9 -22 129 119 62.0 52.1 3 -27 15 159 61.4 4 10 160 58.4 -12 13 154 52.6 -17 15 156 62.7 2 17 122 62.9 -6 19 161 29 193 61.9 67.4 13 31 27 189 60.1 13 27 155 20 170 61.7 63.7 5 11 27 284 63.0 14 -62 56 23.7 -100 26 174 61.7 11 WT. CHG. FROM WEEK 19 279 378 309 381 334 291 229 262 293 341 344 303 213 295 331 3S3 289 318 341 220 330 BFG 002811 REPRODUCTION STUDY 96-40808 E-148 APPENOIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PZ GENERATION WEEK #: 28 DOSE LEVEL 10.0000 PPM MALES ANIMAL NO. 2068 2070 2072 2073 2074 2075 2076 2077 2078 WEIGHT G 406 455 449 452 476 440 431 450 490 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 12 151 62.9 0 23 179 67.3 4 16 164 62.0 9 15 180 67.5 -1 24 186 66.8 2 18 167 64.6 2 14 167 65.6 3 17 1S5 58.5 2 14 188 64.9 2 WT. CHS FROM WEEK 19 249 310 315 310 337 292 277 278 319 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 451.6 13.S 160.6 60.1 -1.2 304.0 STD. DEV. 53.2 17.1 27.4 8.1 21.7 41.8 BFG 002812 REPRODUCTION STUDY 96-4060B -149 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND POOD CONSUMPTION PREHATING TREATMENT PERIOD - P2 GENERATION WEEK #: 28 DOSE LEVEL - 100.0000 PPM MALES ANIMAL NO. 3031 3032 3033 3034 303S 3037 3039 3041 3042 3043 3045 3046 3047 3046 3049 3050 3051 3052 305S 3057 3058 WEIGHT G 534 510 379 403 437 438 401 418 403 478 418 438 461 517 441 392 378 486 423 439 426 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 27 191 61.2 17 20 184 61.3 -6 23 159 72.1 T 25 160 68.3 38 24 167 65.5 3 15 157 60.8 4 31 155 67.0 19 32 174 72.1 23 30 186 79.9 21 27 174 62.4 16 21 182 74.4 35 19 172 66.9 14 24 175 65.0 29 31 201 66.6 9 22 154 59.7 4 21 141 61.6 -3 14 145 65.1 3 23 164 64.6 14 16 166 66.7 7 30 175 68.8 8 13 168 66.7 14 WT. CHG. FROM WEEK 19 350 327 283 316 335 281 280 353 338 315 259 298 289 322 328 282 230 337 255 318 302 bfg 002813 REPRODUCTION STUDY 96-4080B E-150 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 28 DOSE LEVEL 100.0000 PPM MALES ANIMAL NO. 30S9 3061 3063 3064 3065 3066 3067 3069 3070 WEIGHT G 457 465 472 455 411 420 479 483 419 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 27 164 61.6 24 21 165 60.5 13 16 171 61.4 14 11 158 58.6 -5 5 165 67.3 -6 16 162 65.5 2 9 187 65.7 16 25 198 70.1 T 13 S S S T - TECHNICAL PROBLEM WT. CHG FROM WEEK 19 291 317 281 291 252 264 333 323 268 S SPILLAGE NO. OF ANIMALS 30 30 29 29 27 30 MEANS STD. DEV. 442.7 39.9 21.0 7.1 170.3 14.7 65.8 4.8 12.2 11.7 300.9 31.4 BFG 002814 REPRODUCTION STUDY 96-4060B E-151 APPENDIX E (cent.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BOOT WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 28 DOSE LEVEL - 1100.0000 PPM MALES ANIMAL NO. 4031 4033 4035 4037 4039 4041 4043 4045 4046 4047 4049 4050 4052 4054 4056 4056 4060 4062 4064 4066 4068 WEIGHT G 495 466 508 503 462 475 430 431 437 430 442 432 460 400 344 420 451 399 465 470 464 WEIGHT POOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 21 187 64.3 0 25 171 62.8 14 25 177 59.5 0 30 192 65.6 12 16 168 61.7 5 21 177 63.5 7 18 172 68.1 1 17 154 60.7 0 11 170 65.7 3 21 169 17 178 67.1 68.4 28 22 21 164 64.8 -1 17 172 63.5 6 22 155 66.4 7 8 123 60.3 -2 23 157 64.1 5 32 180 69.0 12 17 S S S 22 180 66.1 12 24 182 66.2 10 22 182 67.0 12 WT. CHG. FROM WEEK 19 326 314 373 338 298 32B 304 293 298 271 352 298 289 2B3 203 300 328 288 298 334 301 BFG 002815 REPRODUCTION STUDY 96-4080B E-152 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK <: 26 DOSE LEVEL 1100.0000 PPM MALES ANIMAL NO. 4070 4071 4072 4073 4074 4076 4077 4079 4081 WEIGHT G 462 480 461 457 447 415 359 373 411 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 16 172 63.1 8 ia 185 65.5 18 25 177 65.8 22 17 161 59.8 1 11 166 62.7 -1 24 159 65.8 5 4 137 64.0 4 22 143 65.8 5 15 172 71.0 1 WT. CHG. FROM WEEK 19 312 332 287 288 288 310 226 266 292 S - SPILLAGE NO. OF ANIMALS 30 30 29 29 29 30 MEANS 441.6 19.4 168.3 64.6 7.1 300.6 STD. DEV. 39.5 6.0 15.3 2.8 7.2 33.4 BFG 002816 REPRODUCTION STUDY 96-4080B E-153 APPENDIX E (cont.) VINYL CHLORIDE COWINEO INHALATION TUO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS INDIVIDUAL BODY HEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOO - P2 GENERATION WEEK #: 28 DOSE LEVEL - 0..0000 PPM FEMALES ANIMAL NO. 1531 1533 1535 1537 1535 1539 1540 1541 1542 1543 1545 1547 1549 1551 1553 1555 1557 1558 1SS9 1561 1563 WEIGHT 238 276 281 269 271 280 233 222 248 265 281 256 230 282 282 275 245 239 224 272 239 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT 6/KG/DAY G/INT -1 117 81.8 7 3 115 69.8 4 3 136 81.1 20 -7 127 77.7 13 0 131 80.6 7 -1 130 77.2 9 -4 108 76.6 6 -8 96 70.8 -15 4 101 68.4 0 7 120 76.5 14 23 125 77.3 4 -4 109 70.4 -18 3 110 80.2 -10 6 133 79.5 20 7 124 74.2 1 13 118 73.2 -3 1 104 70.9 -6 10 108 76.9 7 9 94 71.4 6 19 117 74.3 7 2 129 90.3 T WT. CHG. FROM WEEK 19 106 201 152 141 153 153 138 96 113 128 176 190 169 142 144 155 128 124 103 165 115 BFG 002817 REPRODUCTION STUDY 96-4080B E-154 APPENDIX E (eont.) VINYL CHLORIOE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND POOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 28 DOSE LEVEL 0.0000 PPM FEMALES ANIMAL NO. 1565 1566 1568 1570 1572 1574 1576 1578 1580 HEIGHT G 273 264 234 294 286 242 273 242 247 HEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 3 103 63.2 -14 -3 113 -3 107 70.9 75.7 -13 -6 7 130 74.6 6 10 126 74.7 3 -5 117 79.8 7 -1 132 BO.4 10 4 125 86.8 23 8 102 70.0 1 WT. CHG. FROM HEEK 19 153 124 114 157 160 120 139 113 127 T TECHNICAL. PROBLEM NO. OF ANIMALS 30 30 30 30 29 30 MEANS 256.6 3.5 116.9 75.8 3.1 140.0 STO. DEV. 21.1 7.2 11.9 5.6 10.5 25.7 BFG 002818 REPRODUCTION STUDY 96-40806 E-155 APPENDIX E (cont.) VINYL CHLORIDE COMBINEO INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND POOD CONSUMPTION PREMATING TREATMENT PERIOO - P2 GENERATION WEEK 1: 26 DOSE LEVEL - 10.0000 PPM FEMALES ANIMAL NO. 2532 2533 2534 2536 2536 2540 2541 2543 2544 2546 2548 2550 2552 2553 2554 2555 2556 2557 2558 2559 2561 WEIGHT G 280 255 300 266 254 260 263 255 241 277 246 224 245 247 266 261 272 276 267 281 257 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/QAY G/INT 10 132 80.0 T -1 116 75.7 12 9 126 71.1 2 -2 123 76.8 -9 -3 101 65.9 -10 -3 109 69.5 -10 7 120 77.1 6 11 130 86.8 0 -3 107 73.5 -7 4 134 81.2 10 3 113 77,0 11 4 107 80.3 T 19 109 77.1 6 1 107 72.3 5 -1 121 75.7 -1 3 143 a 137 85.3 65.2 1 8 11 118 72.7 -9 4 113 71.1 -4 7 124 74.5 2 22 123 83.3 23 WT. CHG FROM WEEK 19 144 121 152 141 117 150 131 154 108 158 117 127 120 113 133 141 132 113 106 140 147 BFG 002819 REPRODUCTION STUDY 96-4080B E-156 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BOOT HEIGHT AND FOOO CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 26 DOSE LEVEL - 10.0000 PPM FEMALES ANIMAL NO. 2563 2566 2567 2569 2571 2573 2575 2577 WEIGHT G 290 272 245 23S 275 251 262 256 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 1 108 62.2 -23 7 127 78.8 -3 9 119 82.5 9 9 118 85.3 15 30 149 95.5 29 2S S S 11 136 88.4 3 26 137 93.2 26 WT. CHG FROM WEEK 19 168 134 114 111 155 142 125 136 T - TECHNICAL. PROBLEM S SPILLAGE NO. OF ANIMALS 29 29 28 28 26 29 MEANS STD. DEV. 262.1 17.0 7.1 6.4 121.7 12.3 78.5 7.7 3.5 11.9 132.8 16.8 BFG 002820 REPRODUCTION STUDY 96-4OSOB E-157 APPENDIX E (cent.) VINYL CHLORIDE COMBINEO INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT ANO FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PZ GENERATION WEEK #: 28 OOSE LEVEL - 100.0000 PPM FEMALES ANIMAL NO. 3531 3532 3533 3534 3535 3536 3537 3536 3539 3541 3543 3545 3547 3549 3550 3551 3553 3554 3555 3556 3567 WEIGHT G 276 263 261 260 253 245 206 224 241 231 269 242 266 254 235 230 253 301 264 219 244 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT a 128 77.9 3 6 145 86.3 0 4 132 84.9 -8 7 120 78.0 3 7 117 78.2 T 18 124 87.6 9 6 149 121.1 27 2 91 66.0 -16 11 108 76.4 -1 0 117 84.4 -2 4 123 76.8 -3 11 128 90.2 14 10 S S S 8 104 69.3 -3 2 111 79.1 -5 11 114 84.6 14 14 106 71.8 8 S 131 73.5 17 12 128 82.7 15 4 118 90.6 16 7 135 93.6 16 WT. CHG. FROM WEEK 19 143 149 176 173 149 145 104 114 123 172 139 127 118 151 139 113 115 167 132 107 121 BFG 002821 REPRODUCTION STUDY 96-4080B -158 APPENDIX E (cont.) VINYL CHLORIOE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS WEEK #: INDIVIDUAL BODY WEIGHT AND FOOO CONSUMPTION PREMATING TREATMENT PERIOO - P2 GENERATION 28 DOSE LEVEL - 100.0000 PPM FEMALES ANIMAL NO. 3558 3559 3560 3562 3564 3565 3566 3567 3568 WEIGHT G 310 296 290 266 263 232 246 27B 216 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 22 145 80.8 -5 5 147 83.5 16 2 126 72.7 20 *10 S S S 13 136 88.4 15 6 114 83.0 8 0 120 81.3 4 8 134 Bl.S 5 10 61 64.0 -14 T - TECHNICAL PROBLEM WT. CHG. FROM WEEK 19 171 139 ISO 123 120 103 127 14S 75 S - SPILLAGE NO. OF ANIMALS 30 30 2B 28 27 30 MEANS STD. DEV. 255.3 25.8 7.2 5.9 122.6 16.1 81.8 10.5 5.7 10.8 134.3 24.1 BFG 002822 REPRODUCTION STUDY 96-40806 -159 APPENDIX E (cent.} VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BOOY WEIGHT ANO FOOO CONSUMPTION PREHATING TREATMENT PERIOD - P2 GENERATION WEEK #: 26 OOSE LEVEL - 1100.0000 PPM FEMALES ANIMAL NO. 4531 4533 4535 4537 4538 4540 4542 4545 4546 4548 4549 4551 4S52 4554 4555 4556 4557 4558 4560 4562 4563 WEIGHT G 285 276 258 251 289 315 260 215 236 271 277 292 270 278 255 238 257 250 282 256 231 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 9 109 64.8 -15 9 124 73.7 -6 5 117 76.3 3 8 107 72.2 -2 24 133 80.0 3 10 141 75.8 -1 14 115 75.8 -2 2 104 81.0 6 3 101 71.8 -7 12 130 81.8 -1 16 137 84.9 9 6 138 79.6 10 4 143 88.9 22 10 123 75.1 -5 5 112 73.9 -6 13 111 79.9 -3 15 108 72.1 -1 4 114 76.6 6 7 138 82.6 11 10 124 82.3 11 7 107 78.4 8 WT. CHG FROM WEEK 19 144 133 132 109 152 182 129 119 118 196 150 153 151 136 122 130 146 143 142 120 104 BFG 002823 REPRODUCTION STUDY 96-4080B -160 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOO CONSUMPTION PREMATING TREATMENT PERIOD P2 GENERATION WEEK #: 28 OOSE LEVEL - 1100.0000 PPM FEMALES ANIMAL NO. 4564 4566 4568 4570 4572 4574 4575 4577 4579 WEIGHT G 227 275 272 242 275 228 237 197 247 NO. OF ANIMALS 30 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 14 106 80.3 4 6 116 71.1 -20 11 116 72.5 -1 9 118 82.8 10 3 118 71.9 -2 3 106 78.0 -3 3 97 68.6 -5 5 96 82.3 -5 0 114 76.9 0 30 30 30 30 WT. CHG. FROM WEEK 19 124 140 162 107 143 140 116 137 133 30 MEANS 258.1 7.6 117.4 77.1 0.6 137.1 STD. DEV. 25.5 6.0 13.2 5.3 8.3 20.3 BFG 002824 REPRODUCTION STUDY 96-4080B -161 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK 1: 29 DOSE LEVEL - 0. 0000 PPM MALES ANIMAL NO. 1031 1032 1033 1035 1037 1039 1041 1043 1045 1047 1048 1052 1054 1056 1057 1058 1060 1061 1062 1063 1064 1WEIGHT G 476 447 522 483 394 434 348 422 460 424 362 434 435 448 464 359 452 444 454 463 453 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 10 164 58.0 -6 12 159 60.1 -7 13 179 57.9 -10 15 162 56.8 -4 11 134 57.5 -i 12 140 54.5 -7 10 125 60.7 -7 15 141 56.7 -7 10 165 60.4 -3 30 157 64.0 4 11 140 65.5 8 11 154 59.9 -1 20 153 60.0 T 13 158 59.6 -2 17 159 58.2 -17 15 129 61.2 -8 18 167 62.8 13 10 150 56.9 9 15 160 59.7 -4 18 163 59.8 17 8 168 62.4 -1 WT. CHG. FROM WEEK 19 304 370 365 339 272 298 273 275 323 356 302 290 302 310 332 250 292 287 317 340 302 BFG 002825 REPRODUCTION STUDY 96-4080B -162 APPENOIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS INDIVIDUAL SOOT WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 29 DOSE LEVEL 0. 0000 PPM MALES ANIMAL NO. 1066 1068 1070 1071 1072 107* 1076 1078 WEIGHT G 387 495 454 463 485 431 458 497 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY g/int 10 138 60.2 3 22 169 58.2 7 23 174 65.5 2 ia 170 62.4 -4 15 16B 58.6 -18 -2 121 46.7 -44 14 155 57.3 -12 9 175 59.2 -14 WT. CHG. FROM WEEK 19 235 337 328 299 313 259 290 339 T - TECHNICAL PROBLEM NO. OF ANIMALS 29 MEANS 443.0 29 13.9 29 155.1 29 59.3 28 -5.3 29 306.9 STD. DEV. 41.4 5.8 15. S 3.6 11.0 33.2 BFG 002826 REPRODUCTION STUDY 96-40808 E-163 APPENDIX E (eont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL 800Y WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 29 DOSE LEVEL - 10 .0000 PPM HALES ANIMAL NO. 2031 2033 2034 2036 2037 2038 2040 2042 2044 2046 2048 2050 2052 2054 2056 2058 2060 2062 2064 2066 2067 WEIGHT G 448 590 477 569 $04 420 369 372 446 471 503 439 345 462 510 559 443 463 526 392 495 WEIGHT FOOD CONSUMPTION CHAN6E ACTUAL CHANGE 6 G/INT G/KG/QAY G/INT 9 156 59.4 2 30 193 55.9 17 21 178 53.6 13 16 201 59.7 2 17 158 53.1 4 7 132 52.8 -15 18 130 60.2 1 2S S S 7 163 61.4 4 9 164 58.6 4 9 169 56.5 15 17 151 58.5 -5 13 124 61.1 2 19 157 57.8 -4 18 186 61.9 -7 21 194 58.9 5 11 142 a 153 54,1 55.6 -13 -17 26 178 57. B -6 15 137 59.4 79 12 153 52.1 -21 WT. CHG. FROM WEEK 19 288 408 330 397 351 298 247 264 300 350 353 320 226 314 349 374 300 326 367 235 342 BFG 002827 REPRODUCTION STUDY 96-4080B -164 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOO - P2 GENERATION WEEK #: 29 DOSE LEVEL - 10.0000 PPM MALES ANIMAL NO. 2068 2070 2072 2073 2074 2075 2076 2077 2078 WEIGHT G 425 475 473 467 492 458 458 460 517 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE 6 G/INT G/KG/QAY G/INT 19 141 56.6 -10 20 171 61.3 -8 24 1SS 56.0 -9 15 172 62.4 -8 16 184 63.4 -2 16 169 62.7 2 27 168 63.0 1 10 152 55.7 -3 27 184 60.9 -4 WT. CHG FROM WEEK 19 268 330 339 325 353 310 304 2B8 346 S - SPILLAGE NO. OF ANIMALS 30 MEANS 467.6 STD. DEV. 56.2 30 16.0 6.8 29 162.7 20.0 29 58.6 3.3 29 0.7 17.5 30 320.1 44.1 BFG 002828 REPRODUCTION STUDY 96-4080B E-165 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 29 DOSE LEVEL - 100.0000 PPM MALES ANIMAL NO. 3031 3032 3033 3034 3035 3037 3039 3041 3042 3043 3045 3046 3047 3048 3049 3050 3051 3052 3055 3057 3058 WEIGHT G 548 526 395 418 449 452 416 442 423 494 447 457 4SS 524 464 409 399 505 435 457 439 WEISHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE 6 G/INT 6/KG/DAY G/INT 14 179 55.1 -12 16 171 55.0 -13 16 153 65.9 -6 15 153 62.1 -7 12 148 55.7 -19 14 155 58.1 -2 15 165 67.3 10 24 173 67.1 -1 20 172 69.4 -14 16 179 61.4 5 29 182 70.1 0 19 179 66.7 7 24 177 62.4 2 7 186 59.6 -15 23 156 57.5 2 17 141 58.7 0 21 152 65.2 7 19 178 59.9 -6 12 158 61.4 -8 18 177 65.8 2 13 167 64.4 -1 WT. CHG. FROM WEEK 19 364 343 299 331 347 295 295 377 358 331 298 317 313 329 351 299 251 356 267 336 315 BFG 002829 REPRODUCTION STUDY 96-4080B E-166 APPENDIX E (cont.) VINYL CHLORIDE COWINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOO CONSUMPTION PREMATING TREATMENT PERIOO - P2 GENERATION WEEK #: 29 DOSE LEVEL - 100.0000 PPM MALES ANIMAL NO. 3059 3061 3063 3064 3065 3066 3067 3069 3070 WEIGHT G 466 479 484 464 427 431 496 499 431 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 9 159 57.4 -5 14 143 50.5 -22 12 165 57.5 -6 9 162 56.8 4 16 169 67.2 4 11 151 59.1 -11 19 182 62.1 -5 16 193 65.5 -5 12 S S S VT. CHG FROM WEEK 19 300 331 293 300 268 275 352 339 260 5 - SPILLAGE NO. OF ANIMALS 30 MEANS 456.8 STD. DEV. 39.0 30 16.1 4.9 29 166.4 13.7 29 61.6 4.9 29 -4.0 8.0 30 317.0 32.2 bfg 002830 REPRODUCTION STUDY 96-4080B >167 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK I: 29 DOSE LEVEL 1100.0000 PPM MALES ANIMAL NO. 4031 4033 4035 4037 4039 4041 4043 4045 4046 4047 4049 4050 4052 4054 4056 405S 4060 4062 4064 4066 4068 WEIGHT G 512 482 524 538 483 498 459 451 460 445 473 452 479 418 367 441 469 418 453 486 490 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE 6 G/INT G/K6/DAY G/INT 17 181 16 169 59.9 59.4 -6 -2 16 174 56.2 -3 35 199 63.7 7 21 168 23 173 29 171 59.3 59.3 64.1 0 -4 -1 20 166 62.7 12 23 167 62.1 -3 15 160 61.0 -9 31 183 66.7 5 20 167 19 166 18 150 63.0 58.9 61.1 3 -6 -5 23 125 S8.6 2 21 177 68.5 20 18 175 19 S 63.4 S -5 S -12 165 S9.9 -15 16 161 26 178 63.1 62.2 -1 .4 WT. CHG FROM WEEK 19 343 330 339 373 319 351 333 313 321 286 383 318 308 301 226 321 346 307 286 350 327 BFG 002831 REPRODUCTION STUDY 96-4080B -166 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOO CONSUMPTION PREMATING TREATMENT PERIOD P2 GENERATION WEEK #: 29 DOSE LEVEL - 1100.0000 PPM MALES ANIMAL NO. 4070 4071 4072 4073 4074 4076 4D77 4079 4081 WEIGHT G 493 507 492 470 461 435 367 398 435 S - SPILLAGE WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G 6/INT G/KG/DAY G/INT 31 181 63.2 9 27 190 64.2 5 31 180 63.0 3 13 155 14 156 20 165 55.7 57.3 64.7 -6 -10 6 8 129 59.2 -8 25 147 63.6 4 24 182 71.7 10 WT. CHG FROM WEEK 19 343 359 318 301 302 330 234 291 316 NO. OF ANIMALS 30 MEANS 461.9 30 20.2 29 168.3 29 61.9 29 -0.1 30 320.8 STD. DEV. 40.9 8.6 16.2 3.5 7.5 36.1 BFG 002832 REPRODUCTION STUDY 96-4060B E-169 APPENDIX E (cont.) VINYL CHLORIDE COHBINEO INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT ANO FOOD CONSUMPTION PREHATING TREATMENT PERIOD - P2 GENERATION WEEK #: 29 DOSE LEVEL 0..0000 PPM FEMALES ANIMAL NO. 1531 1533 1535 1537 1538 1539 1540 1541 1542 1543 1545 1547 1549 1551 1553 155S 1557 1558 1559 1561 1563 WEIGHT G 252 290 294 283 289 299 255 232 248 269 278 270 237 304 295 269 249 250 234 267 253 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 14 114 77.6 -3 14 123 72.4 8 13 136 78.8 0 14 121 73.1 -6 18 131 78.0 0 19 133 76.6 3 22 113 77.2 5 10 112 82.2 16 0 88 59.1 -13 4 107 66.8 -13 -3 133 79.3 8 14 117 74.1 8 7 113 80.7 3 22 140 79.6 7 13 S S S -6 113 4 104 69.2 70.2 -5 0 11 111 75.7 3 10 103 75.0 9 -5 106 65.6 -11 14 131 88.8 2 WT. CHG. FROM WEEK 19 120 215 165 155 171 172 160 106 113 132 173 204 176 164 157 149 132 135 113 160 129 BFG 002833 REPRODUCTION STUDY 96-40806 E-170 APPENOIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS IN0IV10UAL BODY WEIGHT AND fOOO CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 29 DOSE LEVEL - 0. 0000 PPM FEMALES ANIMAL NO. 1S65 1566 1566 1570 1572 1574 1576 1578 15B0 WEIGHT G 279 262 250 310 305 261 277 247 252 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 6 105 63.4 2 -2 107 67.8 6 16 105 16 126 19 137 72.3 70.6 77.3 -2 -2 n 19 126 83.5 9 4 122 73.9 -10 S 110 75.0 -15 5 106 70.8 4 WT. CHG FROM WEEK 19 159 122 130 173 179 139 143 118 132 S - SPILLAGE NO. OF ANIMALS 30 30 29 29 29 30 MEANS 266.7 9.9 117.1 74.3 0.4 149.9 STD. DEV. 22.4 8.0 12.6 6.3 7.9 26.9 BFG 002834 REPRODUCTION STUDY 96-4080B E-171 APPENDIX E (cont.) VINYL CHLORIOE COMBINEO INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOO - P2 GENERATION WEEK #: 29 DOSE LEVEL - 10.0000 PPM FEMALES ANIMAL NO. 2532 2533 2534 2536 2538 2540 2541 2543 2544 2546 2548 2550 2552 2553 2554 2555 2556 2557 2558 2559 2561 WEIGHT 6 289 272 311 275 269 274 263 266 244 285 253 227 237 286 282 296 277 280 278 283 251 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 9 113 66.2 -19 17 106 11 125 3 122 $7.0 68.2 75.2 -10 -1 -1 15 112 71.4 11 14 107 66.8 -2 0 111 70.3 -9 13 128 81.6 -2 3 114 78.4 7 8 123 73.0 -11 7 109 72.8 -4 3 106 78.3 -1 <8 89 61.5 -20 39 136 85.1 29 16 114 69.3 -7 15 134 77.4 -9 5 133 80.6 -4 4 96 57.6 -22 11 11B 72.2 5 2 117 69.1 -7 6 95 62.3 -28 WT. CHG. FROM WEEK 19 153 138 163 150 132 164 131 167 111 166 124 130 112 152 149 156 137 117 117 142 141 BFG 002835 REPRODUCTION STUDY 96-4080B -172 APPENDIX E (contO VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 29 DOSE LEVEL 10.0000 PPM FEMALES ANIMAL NO. 2563 2566 2567 2569 2571 2573 2575 2577 WEIGHT G 303 276 248 245 265 265 259 263 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 13 116 66.3 10 4 113 68.7 -14 3S S S 10 112 77.8 6 -10 14 114 S 70.4 S -35 S -3 113 72.3 -23 5 124 79.3 -13 WT. CHG FROM WEEK 19 181 138 117 121 145 156 122 141 S - SPILLAGE NO. OF ANIMALS 29 MEANS 269.8 STD. DEV. 19.4 29 27 7.7 114.9 9.4 11.4 27 71.8 6.6 27 -6.9 13.2 29 140.4 18.6 BFG 002836 REPRODUCTION STUDY 96-4080B E-173 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD P2 GENERATION WEEK #: 29 DOSE LEVEL 100..0000 PPM FEMALES ANIMAL NO. 9531 3532 3533 3534 3535 3536 3537 3538 3539 3541 3543 3545 3547 3549 3550 3551 3553 3554 3555 3556 3557 WEIGHT G 297 308 257 252 250 254 215 232 256 233 280 246 281 263 239 238 259 308 268 225 249 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G 6/INT 6/KG/OAY G/INT 19 120 69.6 -8 ZS ISO 64.6 5 -4 113 72.7 -19 -8 99 64.5 -21 -3 115 76.2 -2 9 120 SO.2 -4 7 109 a 104 8S.9 76.0 -40 13 15 105 70.4 -3 2 98 70.4 -19 11 130 78.9 7 4 113 77.2 -15 13 112 68.0 T 9 108 69.6 4 4 102 71.7 -9 8 106 75.5 -8 6 100 65.1 -6 7 124 67.9 -7 4 122 76.4 -6 6 125 93.8 7 5 108 73.0 -27 WT. CHG. FROM WEEK 19 162 174 172 165 146 154 111 122 138 174 150 131 131 160 143 121 121 174 136 113 126 BFG 002837 REPRODUCTION STUDY 96-40808 E-174 APPENDIX (cont.J VINYL CHLORIOE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK #: 29 DOSE LEVEL - 100. 0000 PPM FEMALES ANIMAL NO. 3558 3559 3560 3562 3564 3565 3566 3567 3566 WEIGHT G 312 310 306 287 276 236 258 285 257 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 2S S S 14 154 84.7 7 16 132 73.8 6 21 137 82.6 T 13 131 81.0 -5 4 96 69.8 -16 12 120 79.4 0 7 124 73.4 -10 41 147 103.6 66 T - TECHNICAL PROBLEM WT. CHS FROM WEEK 19 173 153 166 144 133 107 139 152 116 S - SPILLAGE NO. OF ANIMALS 30 30 29 29 27 30 MEANS 264.6 9.2 116.1 76.4 -4.1 143.6 STD. DEV. 27.6 9.3 15.6 8.5 18.4 21.0 BFG 002838 REPRODUCTION STUDY 96-4080B E-175 APPENDIX E (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOQ - P2 GENERATION WEEK t: 29 DOSE LEVEL - 1100.0000 PPM FEMALES ANIMAL NO. 4S31 4S33 4S3S 4537 4536 4540 4542 4545 4546 4546 4549 4551 4552 4554 4555 4556 4557 4558 4560 4562 4563 WEIGHT 6 292 295 267 259 266 321 269 224 236 266 263 302 273 285 264 242 269 261 294 252 246 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 7 126 72.8 17 19 133 77.6 9 9 121 76.8 4 6 122 79.7 15 -3 128 74.2 -5 6 141 73.9 0 9 118 74.4 3 9 96 0 98 74.4 69.2 -6 -3 15 143 85.6 13 6 112 66.7 -25 10 202 113.4 64 3 116 72.4 -25 7 118 69.9 -5 9 121 77.7 9 4 120 12 116 11 no 12 140 63.3 74.8 71.8 81.0 9 10 -4 2 -4 114 17 114 74.8 79.3 -10 7 WT. CHG FROM WEEK 19 151 152 141 117 149 188 138 128 118 211 156 163 154 143 131 134 158 154 154 116 121 BFG 002839 REPRODUCTION STUDY 96-4080B E--176 APPENDIX E (cent.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL 800Y WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - P2 GENERATION WEEK I: 29 OOSE LEVEL - 1100.0000 PPM FEMALES ANIMAL NO. 4564 4566 4566 4570 4572 4574 4575 4577 4579 WEIGHT G 233 2B3 267 241 293 231 251 200 257 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/1NT G/KG/OAY G/INT 6 113 81.9 7 8 134 80.0 18 IS 123 73.3 7 -1 111 76,6 -7 18 121 71,0 3 3 110 79.9 4 14 106 72.4 9 3 97 81.4 1 10 111 73.4 -3 WT. CHS FROM WEEK 19 130 146 177 106 161 143 130 140 143 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 266.1 8.1 121.4 77.1 3.9 145.2 STD. DEV. 26.9 5.9 19.3 6.2 IS.3 22.0 BFG 002840 APPENDIX F BFG 002841 REPRODUCTION STUDY 96-4080B F-l APPENDIX F VINYL CHLORIOE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION HATING AND POSTMATING PERIOOS - P2 GENERATION MALES WEEK #: 30 OOSE LEVEL 0.0000 PPM MALES ANIMAL NO. 1031 1032 1033 1035 1037 1039 1041 1043 1045 1047 1046 1052 1054 1056 1057 1056 1060 1061 1062 1063 WEIGHT G 476 456 513 482 395 427 347 429 451 425 367 440 432 442 456 356 441 456 456 456 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT 6/KG/DAY G/INT BFG 002842 REPRODUCTION STUDY 96-4080B F-2 APPENDIX F (cont.) VINYL CHLORIDE C0M8INE0 INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL 800Y WEIGHT AND FOOD CONSUMPTION HATING AND POSTMATING PERIODS - P2 GENERATION KALES WEEK f: 30 DOSE LEVEL - 0.0000 PPH HALES ANIMAL NO. 1064 1066 1068 1070 1071 1072 1074 1076 1078 WEIGHT G 439 37B 460 452 456 471 453 437 504 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/ZNT G/KG/DAY G/INT NO. OF ANIHALS 29 MEAN 440.7 STO. DEV. 39.8 BFG 002843 REPRODUCTION STUDY 96-408QB f-3 APPENDIX F (cont.) VINYL CHLORIDE COHBINEO INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUOY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION MATING ANO POSTMATING PERIOOS - P2 GENERATION MALES WEEK #: 30 DOSE LEVEL 10.0000 PPM MALES ANIMAL NO. 2031 2033 2034 2036 2037 2038 2040 2042 2044 2046 2048 2050 2052 2054 2056 2058 2060 2062 2064 2066 2067 WEIGHT G 443 588 480 563 497 421 376 359 433 472 499 433 351 466 518 536 444 464 522 398 490 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT BFG 002844 REPRODUCTION STUDY 96-408QB F-4 APPENOIX F (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION MATING AND POS7M4TING PERIODS - P2 GENERATION MALES WEEK #: 30 DOSE LEVEL - 10.0000 PPM HALES ANIMAL NO. 2068 2070 2072 2073 2074 2075 2076 2077 2078 WEIGHT G 410 476 475 474 485 455 454 463 505 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT 5/KG/DAY G/INT NO. OF ANIMALS 30 MEAN 465.0 STD. DEV. 54.5 BFG 002845 REPRODUCTION STUDY 96-40808 F-5 APPENDIX F (cont.) VINYL CHLORIDE COMBINEO INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION MATING AND POSTMATING PERIODS - P2 GENERATION MALES WEEK #: 30 DOSE LEVEL * 100.0000 PPM MALES ANIMAL NO. 3031 3032 3033 3034 3035 3037 3039 3041 3042 3043 3045 3046 3047 3048 3049 3050 3051 3052 3055 3057 3058 WEIGHT G 548 521 391 430 457 442 417 448 431 489 454 451 491 521 473 413 390 512 426 456 437 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT BFG 002846 REPRODUCTION STUDY 96-4080B F-6 APPEN01X F (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BOOY WEIGHT AND FOOD CONSUMPTION MATING AND POSTMATING PERIODS - P2 GENERATION MALES WEEK #: 30 DOSE LEVEL - 100.0000 PPM MALES ANIMAL NO. 3059 3061 3063 3064 3065 3066 3067 3069 3070 WEIGHT G *57 *74 *75 459 435 434 498 483 441 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT NO. OF ANIMALS 30 MEAN STD. OEY. 458.5 37.9 BFG 002847 REPRODUCTION STUDY 96-4080B F-7 APPENDIX F {cont.) VINYL CHL0RI0E COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT ANO FOOO CONSUMPTION MATING AND POSTMATING PERIODS - P2 GENERATION MALES WEEK #: 30 DOSE LEVEL 1100.0000 PPM MALES ANIMAL NO. 4031 4033 4035 4037 4039 4041 4043 4045 4046 4047 4049 4050 4052 4054 4056 4058 4060 4062 4064 4066 4068 WEIGHT G 504 475 518 511 464 493 434 430 456 451 489 450 440 422 376 441 460 426 457 480 477 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/1NT BFG 002848 REPRODUCTION STUDY 96-4080B F-8 APPENDIX F (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS INDIVIDUAL BODY WEIGHT ANO FOOO CONSUMPTION MATING AND POSTMATING PERIODS - PZ GENERATION MALES WEEK t: 30 OOSE LEVEL - 1100.0000 PPM MALES ANIMAL NO. 4070 4071 4072 4073 4074 4076 4077 4079 4081 WEIGHT G 491 504 472 468 451 437 361 381 435 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT NO. OF ANIMALS 30 MEAN 45S.1 STD. DEV. 38.3 BFG 002849 REPRODUCTION STUDY 96-40606 F-9 APPENDIX F fcont.) VINYL CHLORIDE COMBINED INHALATION TU0-6ENERAT10N REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS INDIVIDUAL 800Y WEIGHT AND FOOD CONSUMPTION MATING AND POSTMATING PERIODS - P2 GENERATION MALES WEEK #: 31 DOSE LEVEL - 0.0000 PPM MALES ANIMAL NO. 1031 1032 1033 1035 1037 1039 1041 1043 1045 1047 1046 1052 1054 1056 1057 1058 1060 1061 1062 1063 1064 WEIGHT G 493 472 534 492 375 435 357 447 466 444 393 452 457 456 474 383 462 474 482 466 456 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/1NT G/KG/DAY G/INT BFG 002850 REPRODUCTION STUDY 96-4QS0B F-10 APPENOIX F (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION MATING AND POSTMATING PERIODS - P2 GENERATION MALES WEEK #: 31 DOSE LEVEL - 0.0000 PPM MALES ANIMAL NO. 1066 1068 1070 1071 1072 1074 1076 1078 WEIGHT G 403 503 472 472 488 475 454 526 NO. OF ANIMALS 29 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT MEAN 457.4 STD. DEV. 41.7 BFG 002851 REPRODUCTION STUDY 96-4080B F-ll APPENDIX F (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION MATING AND POSTMATING PERIODS - P2 GENERATION MALES WEEK #: 31 DOSE LEVEL - 10.0000 PPM MALES ANIMAL NO. 2031 2033 2034 2036 2037 2038 2040 2042 2044 2046 2048 2050 2052 2054 2056 2056 2060 2062 2064 2066 2067 WEIGHT G 456 603 479 581 525 431 388 393 446 485 511 462 368 470 535 559 456 470 539 431 517 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT BFG 002852 REPRODUCTION STUDY 96-40806 F-12 APPENDIX F (cont.) VINYL CHLORIDE COMBINED INHALATION TW0-6ENERATI0N REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CO RATS INDIVIDUAL BODY WEIGHT AND POOD CONSUMPTION MATING AND POSTMATING PERIODS - P2 GENERATION MALES WEEK #: 31 DOSE LEVEL - 10.0000 PPM MALES ANIMAL NO. 2066 2070 2072 2073 2074 2075 2076 2077 207a WEIGHT 6 425 492 485 481 507 461 463 472 513 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT NO. OF ANIMALS 30 MEAN 480.8 STD. DEV. 53.8 BFG 002853 REPRODUCTION STUDY 96-40BOB F-13 APPENOIX F (cont.) VINYL CHL0RI0E COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BOOT WEIGHT AND FOOD CONSUMPTION MATING AND POSTMATING PERIODS - PZ GENERATION MALES WEEK #: 31 DOSE LEVEL - 100.0000 PPM MALES ANIMAL NO. 3031 3032 3033 3034 3035 3037 3039 3041 3042 3043 3045 3046 3047 3048 3049 3050 3051 3052 3055 3057 3058 WEIGHT G 559 526 410 434 470 472 432 470 455 513 478 467 502 537 492 428 406 535 436 476 449 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY S/IHT BFG 002854 REPRODUCTION STUDY 96-40808 F-l APPENOIX F (cont.) VINYL CHLORIDE C0M8INE0 INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOT IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION MATING AND POSTMATING PERIODS - P2 GENERATION MALES WEEK f: 31 OOSE LEVEL - 100.0000 PPM MALES ANIMAL NO. 3059 3061 3063 3064 3065 3066 3067 3069 3070 WEIGHT G 471 498 498 475 460 446 504 505 458 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT NO. OF ANIMALS 30 MEAN 475.7 STO. OEV. 37.7 BFG 002855 REPRODUCTION STUDY 96-4080B F-15 APPENDIX F (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS INDIVIDUAL BOOT WEIGHT AND FOOD CONSUMPTION MATING ANO POSTMATING PERIODS - P2 GENERATION MALES WEEK #: 31 DOSE LEVEL - 1100.0000 PPM MALES ANIMAL NO. 4031 4033 4035 4037 4039 4041 4043 4045 4046 4047 4049 4050 4052 4054 4056 4058 4060 4062 4064 4066 4068 WEIGHT G 526 491 540 549 496 517 455 47B 472 463 509 466 484 440 399 463 482 444 482 499 505 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT 6/KG/DAY G/INT BFG 002856 REPRODUCTION STUDY 56-40808 P-16 APPENDIX P (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL 80DY WEIGHT AND POOD CONSUMPTION MATING AND POSTMATING PERIODS - P2 GENERATION MALES WEEK #: 31 DOSE LEVEL 1100.0000 PPM MALES ANIMAL NO. 4070 4071 4072 4073 4074 4076 4077 4079 4081 WEIGHT G SOS 524 493 493 474 453 386 407 453 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT NO. OP ANIMALS 30 MEAN 478.3 STD. DEV. 38.7 BFG 002857 REPRODUCTION STUDY 96-40606 F-17 APPENDIX F (eont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BOOT WEIGHT AND FOOO CONSUMPTION MATING ANO POSTMATING PERIODS - PI GENERATION MALES WEEK #: 32 DOSE LEVEL - 0.0000 PPM MALES ANIMAL NO. 1031 1032 1033 1035 1037 1039 1041 1043 1045 1047 1048 1052 1054 1056 1057 1058 1060 1061 1062 1063 1064 WEIGHT G 506 477 544 500 392 440 368 459 478 459 408 463 481 469 479 390 467 487 460 476 472 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 13 161 53.7 161 5 151 53.0 151 10 160 55.7 180 8 156 17 111 5 134 52.4 48.2 51.0 156 111 134 11 123 56.6 123 12 141 51.9 141 10 159 15 156 56.0 57.6 159 156 IS 143 S9.5 143 11 158 24 147 13 160 5 154 57.6 52.2 57.7 53.9 15S 147 160 154 7 130 5 158 13 159 -2 151 56.1 56.7 55.2 52.3 130 158 159 151 10 141 49.9 141 16 161 57.8 161 BFG 002858 REPRODUCTION STUDY 96-40808 F-1B APPENDIX F (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION MATING AND POSTMATING PERIODS - P2 GENERATION MALES WEEK #: 32 DOSE LEVEL - 0.0000 PPM MALES ANIMAL NO. 1066 1068 1070 1071 1072 1074 1076 1078 WEIGHT 6 413 S09 482 490 4B4 490 461 526 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAT G/INT 10 134 54.7 134 6 148 48.7 148 10 164 57.3 164 18 181 62.7 181 -4 146 50.1 146 IS 164 56.6 164 7 146 53.2 146 0 176 55.8 176 NO. OF ANIMALS 29 29 29 29 29 MEANS STD. DEV. 467.2 40.2 9.8 6.1 151.5 15.8 54.6 3.3 151.5 15.8 BFG 002859 REPRODUCTION STUDY 96-40808 F-19 APPENOIX F (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BOOY WEIGHT ANO FOOD CONSUMPTION MATING ANO POSTMATING PERIODS - P2 GENERATION MALES WEEK #: 32 OOSE LEVEL - 10.0000 PPM MALES ANIMAL NO. 2031 2033 2034 2036 2037 2038 2040 2042 2044 2046 2048 2050 2052 2054 2056 2058 2060 2062 2064 2066 2067 WEIGHT G 454 620 493 594 530 435 397 441 458 492 501 472 376 475 534 558 456 463 534 457 518 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT -2 150 54.9 ISO 17 182 49.6 182 14 156 53.S 156 13 162 51.6 162 5 179 56.6 179 4 132 50.8 132 9 137 58.2 137 48 156 63.1 158 12 164 60.5 164 7 161 54.9 161 -10 157 51.7 157 10 153 54.6 153 8 131 58.7 131 5 146 S2.2 148 -1 184 57.4 184 -1 184 54.9 184 0 132 48.2 132 13 150 52.5 150 -5 177 55.0 177 26 147 55.2 147 1 169 54.4 169 BFG 002860 REPRODUCTION STUDY 96-40B0B F-20 APPENDIX F (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION MATING AND POSTMATING PERIODS - P2 GENERATION MALES WEEK #: 32 DOSE LEVEL - 10.0000 PPM MALES ANIMAL NO. 2068 2070 2072 2073 2074 2075 2076 2077 2078 WEIGHT G 439 495 464 486 506 493 469 472 515 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 14 150 57.9 150 3 159 53.7 159 -1 155 53.3 155 5 163 56.2 163 -1 168 55.3 168 12 162 55.4 162 6 156 55.8 156 0 155 54.7 155 2 172 55.8 172 NO. OF ANIMALS 30 30 30 30 30 MEANS 467.9 7.1 159.1 54.9 159.1 STO. DEV. 50.9 10.7 15.3 3.1 15.3 BFG 002861 REPRODUCTION STUDY 96-4080B F-21 APPENDIX F (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION HATING AND POSTDATING PERIODS - P2 GENERATION KALES WEEK I: 32 DOSE LEVEL - 100.0000 PPM MALES ANIMAL NO. 3031 3032 3033 3034 3035 3037 3039 3041 3042 3043 3045 3046 3047 3048 3049 3050 3051 3052 3055 3057 3058 WEIGHT G 563 521 409 454 486 478 434 477 466 519 462 462 514 545 502 435 406 548 436 495 450 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 4 173 51.4 173 -5 163 51.9 163 -1 140 57.0 140 20 169 63.4 169 8 163 56.4 163 6 150 52.6 150 2 146 56.2 146 7 164 57.7 164 11 167 60.4 167 6 171 55.2 171 -16 158 56.0 158 -5 148 53.1 148 12 165 54.1 165 8 175 53.9 175 10 153 51.3 153 7 139 53.7 139 0 132 54.2 132 13 182 56.0 182 0 144 55.0 144 19 180 61. B 180 1 155 57.5 155 BFG 002862 REPRODUCTION STUDY 96-408QB F-22 APPENOIX F (cont.) VINYL. CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION MATING AND POSTMATING PERIODS - P2 GENERATION MALES WEEK /: 32 DOSE LEVEL 100.0000 PPM MALES ANIMAL NO. 3059 3061 3063 3064 3065 3066 3067 3069 3070 WEIGHT 6 477 514 509 492 464 456 516 499 461 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT GAG/DAY G/INT 6 146 51.3 146 16 168 55.3 168 11 168 55.6 168 17 160 55.2 160 4 164 59.2 164 10 163 60.2 163 12 177 57.8 177 -6 171 56.8 171 3 174 63.1 174 NO. OF ANIMALS 30 30 30 30 30 MEANS 481.7 6.0 160.9 56.1 160.9 STD. OEV. 39.3 8.0 13.0 3.3 13.0 BFG 002863 REPRODUCTION STUDY 96-40508 F-23 APPENDIX F (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY VEIGHT AND FOOD CONSUMPTION MATING AND POSTMATING PERIODS - P2 GENERATION MALES WEEK #: 32 DOSE LEVEL - 1100.0000 PPM MALES ANIMAL NO. 4031 4033 4035 4037 4039 4041 4043 4045 4046 4047 4049 4050 4052 4054 4056 4055 4060 4062 4064 4066 4068 WEIGHT G 532 497 559 565 499 529 474 486 478 477 520 469 491 456 410 474 490 460 500 504 507 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANC G G/INT G/KG/DAY G/IN 6 176 55.5 176 6 159 53.6 159 19 172 52.2 172 16 190 56.9 190 3 157 52.6 157 12 166 52.9 166 19 157 56.3 157 B 164 56.7 164 6 162 S6.8 162 14 155 55.0 155 11 176 57.0 176 3 151 53.8 151 7 182 62.2 1BZ 16 152 56.5 152 11 125 51.5 125 11 166 59.1 166 8 172 59.0 172 16 168 61.9 168 18 169 57.4 169 S 177 56.8 177 2 169 55.7 169 BFG 002864 REPRODUCTION STUDY 96-4080B F-24 APPENDIX F (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS INDIVIDUAL BOOT WEIGHT AND FOOD CONSUMPTION MATING AND POSTDATING PERIOOS - P2 GENERATION MALES WEEK #: 32 OOSE LEVEL - 1100.0000 PPM MALES ANIMAL NO. 4070 4071 4072 4073 4074 4076 4077 4079 40Q1 WEIGHT G 523 536 504 503 489 466 396 417 459 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 18 180 58.4 180 12 161 56.9 181 11 175 56.5 175 10 158 52.9 158 15 159 55.0 159 13 162 58.8 162 10 144 61.4 144 10 140 56.6 140 6 176 64.3 176 NO. OF ANIMALS 30 30 30 30 30 MEANS 489.0 10.7 164.7 56.8 164.7 STD. DEV. 39.1 5.0 13.8 3.1 13.8 BFG 002865 REPRODUCTION STUDY 96-40606 F-25 APPENDIX F (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION MATING ANO POSTMATING PERIODS - P2 GENERATION MALES WEEK *: 33 DOSE LEVEL - 0.0000 PPM MALES ANIMAL NO. 1031 1032 1033 1035 1037 1039 1041 1043 1045 1047 1048 1052 1054 1056 1057 1058 1060 1061 1062 1063 1064 WEIGHT G 507 483 542 503 407 443 388 457 467 432 415 464 501 470 479 403 464 499 468 476 461 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 1 155 51.0 -6 6 152 52.8 1 -2 150 46.0 -30 3 152 50.5 -4 15 136 56.7 25 3 131 49.5 -3 20 135 59.5 12 -2 137 49.9 -4 9 154 53.2 -5 -27 119 44.5 -37 7 146 59.1 3 1 157 56.5 -1 20 175 59.4 28 1 155 55.0 -5 0 153 53.2 -1 13 143 60.1 13 -3 157 56.2 -1 12 175 59.2 16 -12 128 45.0 -23 0 138 48.3 -3 -11 144 51.4 -17 WT. CHG FROM WEEK 32 1 6 -2 3 15 3 20 -2 9 -27 7 1 20 1 0 13 -3 12 -12 0 -11 BFG 002866 REPRODUCTION STUDY 96-40808 F-26 APPENDIX F (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BOOT WEIGHT AND FOOD CONSUMPTION MATING AND POSTMATING PERIODS - P2 GENERATION MALES WEEK #; 33 DOSE LEVEL 0.0000 PPM MALES ANIMAL NO. 1066 1068 1070 1071 1072 1074 1076 1078 WEIGHT G 409 511 487 499 489 497 470 530 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT -4 132 53.5 -2 2 152 49.7 4 5 154 53.0 -10 9 174 58.6 -7 5 145 49.7 -1 7 163 55.0 -1 9 151 54.1 5 4 167 52.7 -9 T. CHG. FROM WEEK 32 -4 2 5 9 S 7 9 4 NO. OF ANIMALS 29 29 29 29 29 29 MEANS 470.4 3.1 149.3 53.2 -2.2 3.1 STD. DEV. 38.7 9.5 14.0 4.4 13.8 9.5 BFG 002867 REPRODUCTION STUDY 96-4080B F-27 APPENDIX F (contO VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BOOY WEIGHT AND FOOD CONSLHPTION MATING AND POSTMATING PERIODS - P2 GENERATION MALES WEEK #: 33 DOSE LEVEL - 10.0000 PPM MALES ANIMAL NO. 2031 2033 2034 2036 2037 2038 2040 2042 2044 2046 2048 2050 2052 2054 2056 2058 2060 2062 2064 2066 2067 WEIGHT G 463 642 497 617 540 439 399 465 460 506 508 489 389 486 546 555 476 501 563 473 517 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 9 157 57.1 7 22 200 4 166 52.8 55.9 18 10 23 194 53.4 12 10 171 53.3 -8 4 131 50.0 -1 2 133 55.7 -4 24 164 60.3 6 2 161 58.5 -3 14 166 56.1 7 7 156 51.5 -1 17 166 57.6 13 13 138 60.1 7 11 156 54.8 10 12 183 56.5 -1 -3 165 20 153 49.4 54.7 19 21 18 160 54.2 10 29 169 51.4 -8 16 159 57.0 12 -1 160 51.5 -9 WT. CHG FROM WEEK 32 9 22 4 23 10 4 2 24 2 14 7 17 13 11 12 -3 20 16 29 16 -1 BFG 002868 REPRODUCTION STUDY 96-4080S F-Z8 APPENDIX F (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION HATING AND POSTMATING PERIODS - P2 GENERATION MALES WEEK #: 33 DOSE LEVEL - 10.0000 PPM MALES ANIMAL NO. 2066 2070 2072 2073 2074 2075 2076 2077 207S WEIGHT G 455 497 489 500 489 501 476 474 515 NO. OF ANIMALS 30 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 16 149 55.6 -1 2 1S5 52.1 -4 5 149 S1.0 -6 14 173 58.5 10 -17 121 40.5 -47 8 167 56.0 5 7 152 53.6 -4 2 143 50.4 -12 0 160 51.8 -12 30 30 30 30 WT. CHG. FROM WEEK 32 16 2 5 14 -17 8 7 2 0 30 MEANS 497.6 9.7 159.4 54.0 0.3 9.7 STO. DEV. 52.7 9.6 16.8 3.9 13.1 9.6 BFG 002869 REPRODUCTION STUDY 96-40308 F-29 APPENDIX F (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOO CONSUMPTION MATING AND POSTMATING PERIODS - P2 GENERATION MALES WEEK #: 33 DOSE LEVEL - 100.0000 PPM MALES ANIMAL NO. 3031 3032 3033 3034 3035 3037 3039 3041 3042 3043 3045 3046 3047 3048 3049 3050 3051 3052 3055 3057 3058 WEIGHT G 561 532 415 461 498 493 446 466 478 514 440 454 511 555 506 442 412 554 432 502 439 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHAN6E G G/INT G/KG/OAY G/INT -2 165 48.9 -8 11 170 6 143 53.8 57.8 7 3 7 157 57.2 -12 12 159 57.2 6 15 159 54.6 9 12 143 54.2 -3 9 165 57.1 1 12 173 61.1 6 -5 159 51.3 -12 -22 142 52.5 -16 -8 144 52.4 -4 -3 156 50.7 -9 10 172 4 154 52.1 50.9 -3 1 7 152 57.8 13 6 135 6 173 55.0 52.3 3 -9 -4 136 53.0 -6 7 169 -11 137 56.5 51.4 -11 -18 VT. CHG FROM WEEK 32 -2 11 6 7 12 15 12 9 12 S -22 -6 -3 10 4 7 6 6 -4 7 -11 BFG 002870 REPRODUCTION STUDY 96-40806 F-30 APPENDIX F (cont.) VINYL CHLORIDE COMBINEO INHALATION TWO-GEN ERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT ANO FOOD CONSUMPTION MATING AND POSTMATING PERIODS - P2 GENERATION MALES WEEK *: 33 DOSE LEVEL - 100.0000 PPM MALES ANIMAL NO. 3059 3061 3063 3064 3065 3066 3067 3069 3070 WEIGHT G 466 515 510 502 471 457 519 509 464 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT -11 134 47.4 -12 1 158 51.2 -10 1 160 52.3 8 10 156 52.3 -4 7 163 56.1 -1 1 154 56.2 -9 3 171 55.1 -6 10 173 57.2 2 3S S S WT. CHG FROM WEEK 32 -11 1 1 10 7 1 3 10 3 S - SPILLAGE NO. OF ANIMALS 30 MEANS 484.8 STD. DEV. 40.5 30 3.1 8.4 29 156.7 12.6 29 54.1 3.2 29 -3.8 7.B 30 3.1 8.4 BFG 002871 REPRODUCTION STUDY 96-40808 F-31 APPENDIX F (coni.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOO CONSUMPTION MATING AND POSTMATING PERIODS - P2 GENERATION MALES WEEK #: 33 DOSE LEVEL - J100.0000 PPM MALES ANIMAL NO. 4031 4033 4035 4037 4039 4041 4043 4045 4046 4047 4049 4050 4052 4054 4056 4058 4060 4062 4064 4066 4068 WEIGHT G 544 505 576 574 510 536 487 502 487 489 530 473 497 469 421 491 500 478 503 508 511 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 12 174 53.9 -2 8 153 17 174 50.9 51.1 6 2 9 177 51.8 -13 11 160 52.9 3 7 163 51.0 -3 13 156 54.1 -1 16 160 54.0 -4 9 158 54.6 -4 12 158 54.5 3 10 171 54.3 -5 4 149 52.7 -2 6 161 54.3 -21 13 156 56.2 4 11 144 57.8 19 17 167 57.7 1 10 169 56.9 -3 18 175 62.2 7 3 172 57.2 3 4 170 56.0 -7 4 165 54.0 -4 WT. CHG. FROM WEEK 32 12 S 17 9 11 7 13 16 9 12 10 4 6 13 11 17 10 18 3 4 4 BFG 002872 REPRODUCTION STUDY 96-40808 F-32 APPENDIX F (cont.) VINYL CHLORIDE COHBINEO INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION MATING AND POSTMATINfi PERIODS - P2 GENERATION MALES WEEK I: 33 DOSE LEVEL - 1100.0000 PPM MALES ANIMAL NO. 4070 4071 4072 4073 4074 4076 4077 4079 4081 WEIGHT G 539 538 504 517 497 464 414 423 456 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/1NT G/KG/DAY G/INT 16 173 54.3 -7 2 163 50.6 -16 0 162 53.6 -13 14 165 53.9 7 S 158 53.4 -1 -2 154 55.2 -0 18 139 57.2 -5 6S S S -3 152 55.4 -24 WT. CHG FROM WEEK 32 16 2 0 14 8 -2 18 6 -3 S - SPILLAGE NO. OF ANIMALS 30 30 29 29 29 30 MEANS STD. DEV. 498.1 39.1 9.1 5.9 162.0 9.5 54.5 2.5 -3.5 6.8 9.1 5.9 BFG 002873 REPRODUCTION STUDY 96-40806 F-33 APPENDIX F (cont.) VINYL CHLORIOE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BOOY WEIGHT AND FOOD CONSUMPTION MATING AND POSTMATING PERIODS P2 GENERATION MALES WEEK #: 34 OOSE LEVEL - 0.0000 PPM MALES ANIMAL NO. 1031 1032 1033 1035 1037 1039 1041 1043 1045 1047 1048 1052 1054 1056 1057 1058 1060 1061 1062 1063 1064 WEIGHT G 522 499 567 528 419 452 400 478 496 451 412 470 512 474 499 411 477 510 480 480 461 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 15 166 53.8 11 16 158 53.6 6 25 189 56.8 39 25 170 55.0 18 12 142 57.3 6 9 135 5D.3 4 12 140 59.2 S 21 145 51.7 8 11 167 56.5 13 19 138 52.1 19 -3 139 56.0 -7 6 158 56.4 1 11 161 53.0 -14 4 148 52.3 -7 20 165 56.2 12 8 139 56.9 -4 13 164 58.1 7 11 174 57.5 -1 12 143 50.3 15 4 143 49.9 5 0 135 48.8 -9 WT. CHG. FROM WEEK 32 16 22 23 28 27 12 32 19 20 -8 4 7 31 5 20 21 10 23 0 4 -11 BFG 002874 REPRODUCTION STUDY 96-4080B F-34 APPENDIX F (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION MATING AND POSTDATING PERIODS - P2 GENERATION MALES WEEK f: 34 DOSE LEVEL - 0.0000 PPM MALES ANIMAL NO. 1066 1068 1070 1071 1072 1074 1076 1078 WEIGHT G 416 532 482 505 499 508 477 533 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 7 137 55.4 5 21 157 53.4 15 -5 138 47.5 -16 6 159 52.8 -15 10 162 54.7 17 11 167 55.4 4 7 151 53.2 0 3 178 ss.a 11 WT. CHG FROM WEEK 32 3 23 0 15 15 18 16 7 NO. OF ANIMALS 29 29 29 29 29 29 MEANS STD. DEY. 481.1 41.2 10.7 7.6 154.4 14.9 54.1 2.9 5.1 11.8 13.9 11.1 BFG 002875 REPRODUCTION STUDY 96-40808 F-35 APPENOIX F (cant.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BOOY WEIGHT AND FOOO CONSUMPTION MATING AND POSTMATING PERIOOS - P2 GENERATION MALES WEEK 9: 34 DOSE LEVEL - 10.0000 PPM MALES ANIMAL NO. 2031 2033 2034 2036 2037 2036 2040 2042 2044 2046 2046 2050 2052 2054 2056 2058 2060 2062 2064 2066 2067 WEIGHT G 471 656 500 614 544 454 418 486 467 520 503 507 400 496 558 566 494 515 573 464 511 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 8 152 54.2 -5 14 195 50.1 -5 3 158 52.8 -8 -3 171 46.3 -23 4 175 S3.8 4 15 141 52.6 10 19 139 56.7 6 23 172 60.2 8 7 152 54.7 -9 14 170 55.2 2 -5 140 46.2 -16 18 166 11 134 55.6 56.6 0 -4 10 157 53.3 -1 12 187 56.5 4 11 173 51.4 8 18 165 56.7 12 14 160 52.5 0 10 170 49.9 1 11 142 49.5 -17 -6 153 49.6 -7 WT. CHG FROM WEEK 32 17 36 7 20 14 19 21 47 9 28 2 35 24 21 24 8 38 32 39 27 -7 BFG 002876 REPRODUCTION STUDY 96-4080B F-36 APPENDIX F (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION HATING AND POSTMATING PERIODS - P2 GENERATION MALES WEEK #: 34 DOSE LEVEL - 10. 0000 PPM MALES ANIMAL NO. 2068 2070 2072 2073 2074 2075 2076 2077 2078 WEIGHT G 451 498 512 512 509 515 488 480 517 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY 6/INT -4 98 36.1 -51 1 149 49.9 -6 23 164 54.6 15 12 177 58.3 4 20 163 54.4 42 14 166 54.5 -1 12 151 52.2 -1 6 146 51.7 5 2 156 50.4 -4 WT. CHG. FROM WEEK 32 12 3 28 26 3 22 19 8 2 NO. OF ANIMALS 30 30 30 3Q 30 30 MEANS STD. OEV. 507.4 51.4 9.8 8.0 158.1 18.3 52.5 4.5 -1.2 14.9 19.5 13.0 BFG 002877 REPRODUCTION STUDY 96-40808 F-37 APPENDIX F (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUOY IN CD RATS INDIVIDUAL BOOT WEIGHT ANO FOOD CONSUMPTION MATING AND POSTMATING PERIODS - P2 GENERATION MALES WEEK #: 34 DOSE LEVEL 100.0000 PPM MALES ANIMAL NO. 3031 3032 3033 3034 3035 3037 3039 3041 3042 3043 3045 3046 3047 3048 3049 3050 3051 3052 3055 3057 3058 1WEIGHT G 582 553 436 480 520 513 454 508 498 535 46S 470 521 564 515 457 421 574 453 523 452 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 21 173 50.5 8 21 162 55.9 12 21 153 59.9 10 19 158 56.0 1 22 173 56.6 4 2D 161 53.3 2 8 145 53.7 2 22 178 59.7 13 20 174 59.4 1 21 161 51.2 2 28 168 61.7 26 16 161 58.1 17 10 154 49.7 -2 9 179 53.3 7 9 146 47.7 -8 15 149 55.2 -3 9 135 54.0 0 20 176 52.0 3 21 153 57.6 15 21 178 57.9 9 13 159 59.5 22 WT. CHG FROM WEEK 32 19 32 27 26 34 35 20 31 32 16 6 8 7 19 13 22 15 26 17 26 2 BFG 002878 REPRODUCTION STUDY 96-40806 F-38 APPENOIX F (cont.) VINYL CHLORIOE COMBINES INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION MATING ANO POSTMATING PERIOOS - P2 GENERATION MALES WEEK #: 34 OOSE LEVEL - 100.0000 PPM MALES ANIMAL NO. 3059 3061 3063 3064 3065 3066 3067 3069 3070 1WEIGHT G 479 529 526 512 48S 474 539 516 467 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 13 149 52.6 15 14 163 52.0 5 16 160 51.5 0 10 160 52.6 4 14 158 55.1 -5 17 164 58.7 10 20 185 58.3 14 7 174 56.6 1 3S S S WT. CHG FROM WEEK 32 2 15 17 20 21 18 23 17 6 S SPILLAGE NO. OF ANIMALS 30 MEANS 500.6 30 16.0 29 163.1 29 55.2 29 6.4 30 19.1 STD. DEV. 41.2 5.9 12.5 3.6 8.0 9.3 BFG 002879 REPRODUCTION STUDY 96-40808 F-39 APPENDIX F (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION MATING AND POSTMATING PERIODS P2 GENERATION MALES WEEK #: 34 OOSE LEVEL - 1100.0000 PPM MALES ANIMAL NO. 4031 4033 4035 4037 4039 4041 4043 4045 4046 4047 4049 4050 4052 4054 4056 4058 4060 4062 4064 4066 4068 WEIGHT G 556 516 588 580 509 515 501 512 491 497 531 490 SOS 461 437 500 500 491 517 517 526 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 12 163 55.5 9 11 163 53.2 10 12 171 49.0 -3 6 173 50.0 -4 -1 151 49.4 -9 -21 131 41.5 -32 14 161 54.3 5 10 158 51.9 -2 4 156 53.2 -2 e 146 49.4 -12 i 167 52. S -4 17 154 53.3 5 8 157 52.2 -4 12 155 54.4 -1 16 141 54.8 -3 9 163 54.8 -4 0 159 53.0 -10 13 163 56.1 -12 14 165 53.9 -7 9 170 55.3 0 17 168 53.9 3 WT. CHG FROM WEEK 32 24 19 29 15 10 -14 27 26 13 20 11 21 14 25 27 26 10 31 17 13 21 BFG 002880 REPRODUCTION STUDY 96-4080B F-40 APPENDIX F (cent.) VINYL CHLORIDE COMBINEO INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT ANO FOOD CONSUMPTION MATING AND PQSTMTING PERIODS - P2 GENERATION MALES WEEK #: 34 DOSE LEVEL 1100.0000 PPM MALES ANIMAL NO. 4070 4071 4072 4073 4074 4076 4077 4079 4061 WEIGHT G 548 542 506 521 502 463 416 427 460 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE 6 G/INT G/KG/DAY G/INT 9 177 54.3 4 4 166 2 161 51.9 53.1 5 -1 4 160 51.4 -5 5 155 51.7 -3 -1 154 55.4 0 2 133 53.4 6 4 134 52.5 T 4 149 54.2 3 WT. CHG. FROM WEEK 32 25 6 2 18 13 -3 20 10 1 T - TECHNICAL PROBLEM NO. OF ANIMALS 30 30 30 30 29 30 MEANS 504.9 6.6 156.2 52.6 -3.0 IS.9 STD. DEV. 39.0 7.5 12.5 2.6 7.9 10.3 BFG 002881 REPRODUCTION STUDY 96-4080B F-41 APPENDIX F (eont.) VINYL CHLORIDE COHBINEO INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION MATING AND POSTMATING PERIODS - PZ GENERATION MALES WEEK f: 35 DOSE LEVEL 0.0000 PPM MALES ANIMAL NO. 1031 1032 1033 1035 1037 1039 1041 1043 1045 1047 1048 1052 1054 1056 1057 1058 1060 1061 1062 1063 1064 WEIGHT G 533 514 592 545 438 466 416 482 511 459 424 483 523 483 502 420 487 526 502 500 489 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 11 167 52.8 1 15 161 53.0 3 25 189 54.4 0 17 165 19 143 51.3 55.6 -5 1 14 138 16 128 50.1 52.3 3 -12 4 135 46.9 -10 13 167 55.2 0 8 146 53.5 a 12 S S s 13 151 52.8 -7 11 159 51.2 -2 9 154 3 154 53.6 51.3 6 -11 9 132 52.9 -7 10 164 56.7 0 16 164 22 151 52.8 51.3 -10 8 20 156 53.1 13 28 177 62.1 42 WT. CHS FROM WEEK 32 27 37 48 45 46 26 48 23 33 0 16 20 42 14 23 30 20 39 22 24 17 BFG 002882 REPRODUCTION STUDY 96-4080B F-42 APPENOIX F (cont.J VINYL CHLORIOE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS INOIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION MATING ANO POSTMATING PERIOOS - P2 GENERATION HALES WEEK #: 35 DOSE LEVEL - 0..0000 PPM HALES ANIMAL NO. 1066 1068 1070 1071 1072 1074 1076 1078 WEIGHT G 426 545 SOI 511 514 517 482 550 S - SPILLAGE NO. OF ANIMALS 29 MEANS 494.5 STD. OEV. 42.4 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 10 137 54.2 0 13 170 52.6 3 19 1S9 53.9 21 6 160 52.5 1 15 156 51.3 -6 9 161 52.4 -6 S 148 51.4 -3 17 173 53.2 -5 29 13.4 6.0 28 155.9 14.2 28 53.0 2.6 28 0.9 11.0 WT. CHS FROM WEEK 32 13 36 19 21 30 27 21 24 29 27.3 11.6 BFG 002883 REPRODUCTION STUDY 96-40808 F-43 APPENDIX F (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION MATING AND POSTMATING PERIODS - P2 GENERATION MALES WEEK #: 35 DOSE LEVEL - 10.0000 PPM MALES ANIMAL NO. 2031 2033 2034 2036 2037 2038 2040 2042 2044 2046 2048 2050 2052 2054 2056 2058 2060 2062 2064 2066 2067 WEIGHT G 474 668 509 62B 562 467 428 496 480 524 529 527 404 506 575 583 514 519 581 393 516 WEIGHT FOOD iCONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 3 153 54.0 1 12 190 47.8 -5 9 155 51.2 -3 14 180 48.3 9 18 175 52.7 0 13 135 48.9 -6 10 135 53.2 -4 10 156 52.7 -16 13 153 53.9 1 4 159 50.8 -11 26 174 56.2 34 20 162 52.2 -4 4 125 51.8 -9 10 152 50.6 -5 17 187 55.0 0 17 187 54.3 14 20 165 54.6 0 4 154 49.6 -6 8 176 50.8 6 -91 51 19.4 -91 5 165 53.6 12 WT. CHG. FROM WEEK 32 20 48 16 34 32 32 31 57 22 32 28 55 28 31 41 25 58 36 47 -64 -2 bfg 002884 REPRODUCTION STUDY 96-4080B F-44 APPENDIX F (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION MATING ANO POSTMATING PERIODS - P2 GENERATION MALES WEEK #: 35 OOSE LEVEL - 10.0000 PPM MALES ANIMAL NO. 2068 2070 2072 2073 2074 2075 2076 2077 2078 WEIGHT G 458 514 512 519 511 527 503 485 524 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 7 155 56.8 57 16 171 56.3 22 0 147 47.9 -17 7 175 56.6 -2 2 152 49.7 -11 12 166 53.1 0 15 168 56.5 17 S 147 50.8 -1 7 156 50.0 0 WT. CHG FROM WEEK 32 19 19 2B 33 5 34 34 13 9 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 514.6 7.2 157.5 51.3 -0.6 26.7 STD. OEV. 57.6 19.6 25.5 6.6 22.7 22.4 BFG 002885 REPRODUCTION STUDY 96-40808 F-4S APPENDIX F (cont.) VINYL CHLORIOE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION MATING AND POSTMATING PERIODS - 92 GENERATION MALES WEEK #: 35 DOSE LEVEL - 100.0000 PPM MALES ANIMAL NO. 3031 3032 3033 3034 3035 3037 3039 3041 3042 3043 3045 3046 3047 3048 3049 3050 3051 3052 3055 3057 3058 WEIGHT G 596 565 450 476 522 522 466 523 505 543 482 492 533 576 517 459 421 577 459 537 463 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/1NT G/KG/DAY G/1NT 14 173 49.0 0 12 178 53.1 -4 14 163 61.3 10 -4 161 56.1 3 2 160 51.2 -13 9 153 49.3 8 12 160 54.3 5 15 172 55.6 -6 7 174 57.8 0 8 158 48.9 -3 14 166 58.2 -2 22 1B1 62.7 20 12 161 50.9 7 12 184 53.8 5 2 145 46.8 -1 2 139 50.6 -10 0 128 50.7 -7 3 177 51.3 1 6 150 54.8 -3 14 183 57.5 S 11 156 56.8 -3 WT. CHG FROM WEEK 32 33 44 41 22 36 44 32 46 39 24 20 30 19 31 15 24 15 29 23 42 13 BFG 002886 REPRODUCTION STUDY 96-40806 F-46 APPENDIX F (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL 800Y WEIGHT AND FOOD CONSUMPTION MATING AND POSTMATING PERIODS - P2 GENERATION MALES WEEK #: 35 DOSE LEVEL - 100.0000 PPM MALES ANIMAL NO. 3059 3061 3063 3064 3065 3066 3067 3069 3070 WEIGHT G 485 538 529 523 490 479 546 527 481 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 6 152 52.6 3 9 159 49.7 -4 3 150 47.4 -10 11 164 52.8 4 5 159 54.4 1 5 159 55.6 -5 7 176 54.1 -9 11 190 60.7 16 14 S S S WT. CHG. FROM WEEK 32 8 24 20 31 26 23 30 28 20 S - SPILLAGE NO. OF ANIMALS 30 30 29 29 29 30 MEANS 509.4 6.6 162.8 53.7 -0.3 27.7 STD. DEV. 41.9 5.6 14.4 4.1 7.6 9.9 BFG 002887 REPRODUCTION STUDY 96-40B0B F-47 APPENDIX F (cont.) VINYL CHLORIDE COMBINEO INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION MATING AND POSTMATING PERIOOS - P2 GENERATION MALES WEEK #: 35 DOSE LEVEL - 1100.0000 PPM MALES ANIMAL NO. 4031 4033 4035 4037 4039 4041 4043 4045 4046 4047 4049 4050 4052 4054 4056 4058 4060 4062 4064 4066 4068 WEIGHT G 564 523 585 599 525 522 505 521 502 506 533 509 516 486 442 509 514 499 525 52B 529 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 8 181 53.9 -2 7 161 -3 158 51.7 44.9 -2 -13 19 202 57.1 29 16 168 54.2 17 7 123 39.5 -8 4 155 51.4 -6 9 157 50.7 -1 11 156 52.4 0 9 154 51.2 8 2 143 44.8 -24 19 169 56.4 15 11 158 51.6 1 5 162 55.8 7 5 138 52.3 -3 9 166 54.6 3 14 169 55.6 10 8 170 57.2 7 8 167 53.4 2 11 174 55.5 4 1 159 50.1 -9 WT. CHG FROM WEEK 32 32 26 26 34 26 -7 31 35 24 29 13 40 25 30 32 35 24 39 25 24 22 BFG 002888