Document BybbZRLVddOONz51Nd0Bq3YDj

iCo CPhFaOrlSesPrMe.senAtuaetri,onDitroecCtMoAr, June 19, 2000 CU.hSe.miEcnavlirCoonnmternotlaDliPvriostioenction Agency ARR2G -- 0639 fecenen ANSEP-6 pi pp: 58 BACKGROUND cPhFeOmiSca(lpesrtfoltuaolroaoncntuaanle psurlofdouncitcioanciodf) tihsea PmFeOmSbefraomfilya lisa<rge10fammiilllyioonf sulfonated Ibs) which perfluoroare used for a owfisdoeilvaarnidettyaoifn-inrdeussttrainatl,ccooamtminegrscifaolr,faabnridcsc.onlesautmheerr, afpupnliitcuartei,onasndinccalrpuedtisn,ginusfeiraes-faigchotminpgonent sfpoeacmisa,ltcyoampmpelriccaitailonas)n.d cPoesntsiucmidearl falnodoripndoilrieschtesf,oocldeuasnienpgrpordoudcutcstsa,reaanldsoasmaadsuerffarcotmantthiisn other technology. dAellgroafdtehefsuertchheremiitciaslsthhuasvheigthhleypopteresnitsitaelntt)o.d3egMraCdoerpboarcaktitoonPiFs OtShe wsholiechUdSoemasnnuoftacatpupreearroftothe PFOS family of chemicals pPpFbOlSevhealss bineennonf-oeuxnpdowsieddewloyriknehrsumaandn ibnloboldoosdambpalnekss(apmpplmesl)evbelasseidn omann3ufMacrteusreairncgh.worPkFeOrsS, has dalestoecbteeedninfonuanidvein(uwnieldxlpiofseesdp)ecliaebsoraactroorsysrtahtse US (the (PesFpOecSiaclolnytainmifniashtieoantiwnagsbirradcs)edanbdacwkasto ish meal used in the rat chow). rPeFpOroSduccatuisveedepfofsecttnsatraalt dsetautdhys((NaOndAoEtLheorfd0e.v1elmogp/mkegn/tdaalyeafnfedctLs)OAinEoLffospfrin0.g4 mgin/akg/2d-agye)n.eraAttion Higher weigh dgoasienswiansthoibssesrtvueddy., progeny in the fist generation died, while at the LOAEL reduced pup yPeRaOrsSianchcuummaunlsa.tesTtthaushaipgphedaergsretoecionmhbuimnaensPerasnidstaennicmea,lsB.ioaItcchuamsulaantieosnti,maanteddTohaxlifc-iltifye of4 properties to a high degree p3rMesehnacde,preenvviioruosnlmyelnatuanlcahnedd ha ummaajonrerfefescetasr,chanedffeorntviornonPmFeOntSaltofcathea.raEctPeArizceonittsineunevsirfoonrmeecnetiavle the resultsofths work and will make it available as it comes in. PErPelAimRiEnaVryIdEaWta indicated to EPA that PFOS isofsignificant concern on the basisof evidence of wEidPeAsprperaedlihmuinmaarny erixspkoassusreesasnmdenitndiincdaitciaotnesdopfottoexnitciialtlyyiunntahcece2p-tgaebnlereamtairongirnatsostfudeyx.poIsnuraeddition, (MOE) for workers and possibly the general population 1 There are many assumptions and considerable uncertainty in these arguments and analyses. tis not possible at present to judge the adequacy or accuracyofthe MOE analyses or whether the exposure levels used in the above estimations may be considered representativeofthe affected populations at large. EPA has requested detailed information from 3M and a large body of information has been received but not fully reviewed. Review of subchronic studies provided by 3M on monkeys and rats also show deaths at doses similar to those reported in the 2-gencration study. 3M has raised questions regarding the possible relevance to humans of aproposed mechanism (effects on cholesterol biosynthesis) for PFOS's lethal effect in the 2-generation study. The proposed mechanism, the company argues, affects reproductive outcomes in litter bearing animals due to its inhibitory effect on a burst of cholesterol biosynthesis in the critical periodjust before birth. `The proposed mechanism would, ifdemonstrated, have broad implications for and present significant potential concerns for humans and environmental organisms. At ths time it is not clear what is going on in PFOS toxicology ~ nonetheless, the persistent presenceofdeaths in multiple studies involving multiple species at roughly equivalent doses raises flags. PHASE OUT DECISION BY 3M Following a seriesofdiscussions with EPA, and based on concerns about the widespread presence and longer term risks presented by PFOS, 3M announced that it would exit worldwide from this market by about the endofthe year, although it may need to extend the time period for some critical uses (e.g., fire fighting foam). EPA agrees that continued manufacture and use of POS represents an unacceptable technology that should be climinated to protect human health and the environment from potentially severe long term consequences. The company has committed to continue its research effort despite the `commercial decision. 3M withdraw from the market has and expressed interest in collaborative efforts in the developmentofsafer substitutes. with EPA as they EPA is currently examining appropriate regulatory alternatives necessary to protect human health and environment in light of 3M's phascout decision on PFOS. More information will be made available as our strategy becomes clarified. eEfPfeActssttroonhgulmyasnusppaonrtdstchoenetnivniureodnmreenste.arcAh omnorPeFcOoSmptloeitmeprunodveerosutranudnidnegrostfatnhdeienngvoifroitnmfaetnetaalnd fate the loofngPeFrOtSerdmerciovnastievqeuse,nicnecsloufditnhgepPoFlyOmSerwsh,iicshpahratsicbuelearnlyreilmepaoserdtainnttotothaelleonwviarnonamsesnets.sment of rEiPtiAcails upsreespoarfePd FtoOSwotrokenwsituhreintdhuatstgroy,odbodtehcimsainounfsaacrteurmeardseanindtuhsoesres,ctaoseassswishterinerreivski/erwisokf 2 atcriaddemoifsftisssuupepsreasrseiopnr.esented by the phascout decision. These uses include fire fighting foam and UPsFeOrsSofALPFTOESR-bNaAsTedIVprEoSducAtNs DareRcEoLnfAroTnEtiDngStUheBnSeTeAd NtoCrEeSplace PFOS. Various materials ehvaavleuabteeedntiodeindteinftiiefdy apsosssuibbslteithuatzesarfdororthreissek uissessue.s.EPEAPAreicsopmrmepeanrdesd tthoawtoarltkerwniatthiviensdibveicdauraelfully mtoaneunfsaucrteutrheartsogfoaoldtedrencaitsiivoenss which ar are made. available or under development as substitutes for PFOS AflsuotrhienawtoerdkacoindsP,FiOncSlupdrionggresPsFesO,AEaPnAd poltahnesr tmoatberrioaaldse,nitnsclruedviinegwthteo teenlcoommeprasss other highly PFOA cPeFrtOaiAn (ppoelryfmleuroirzoaotcitoannoriecacatciiodn)s.is EclPoAselhyasrerleaqtueedsstterducitnufroalrlmyattiooPnFfOrSomapnrdodisucuesresdaan5dawsiolllvebnet for epxrpeospuarrei,anangndasrsiesksspmiecnttu.re BcaosmepdaroendptroelPiFmOiSn.ary3iMnfohramsaatlisoon,coPmFmOitAtepdretsoenetnsdaindgifpfreorednutcthiaoznarodf, oPnFOPAF.OA.TheWreeaarreeoatwhearreporfoduincdeursstriyn tchoencUeSrnasnrdegEaPrdAinisgetxheamaivaniilnagbitlistyooptfiosnusbsrteigtuatredsinfgoracPtFioOnA ints fluoropolymer reaction solvent application. TEPEALOhaMsEnoRtSyeAt NlDookOeTd HinEtoRthPeEtRelFomLeUrsOaRnOd oCtHheErMpIerSflTuRorIoEcShemistries. The ITC will be trehqeumesatsinpagritnoffoorumartaisosneosnsmaenbtroeafdforatr.raTyohfe ftleuloormienrasterdepdreersievnattiavnesinatnedrewsteinwgilalltbeernwaotirvkeintog PwFitOhS athnedsewemateenrcioaulsr.ageOfinpdaursttircyuleafrfoirnttserteostitnofoErPmAEPinAthainsdreogtahredrsisretgoaurnddienrgstthaendfattheeaenndviefrfoencmtesnotfal wfahtaeotfartehtehsee mraatteesriaanlds,eixntcelntuodifngthtios wdhegartaedxatteinotnduondtehre vvaarriioouuss ednerviivraotnimveenstdaelgrcoanddeittioonPs.FOA and 3