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Corpor Opn es 3 CoBt SR ARYL6- 04H SIM: Morty study at he 3M Chemalie Plane `This is the first updateofthe retrospective cohort mortality study by University of Minnesota epidemiologists. The original study was completed in 1980 (see study #2). `The study population was defined as all hourly employees who were employed at least six months in the Chemolite (Cottage Grove) plant and, in particular, the Chemical Division. The roster of employees from the initial Chemolite study was updated to include new employees hired since the first study was completed. The study updated the vital statusof employees through 1983. There were no statistically significant findings. `There were three prostate cancer deaths observed versus one expected among Chemical Division employees. A nested case-control study was conductedof the prostate cancer deaths at the Chemolite site. For each case, four matched controls were selected. Individual job histories were reviewed to determineifany job titles or department codes occurred more frequently among cases than controls. There were no significant differences in department codesorjob titles between cases and controls. The authors concluded that the greater number ofobserved prostate cancer deaths may be due to the higher prevalenceofprostate cancer in Minnesota than the U.S. and/or a chancefinding due to the large numberof comparisons that were conducted. 03142 Mortality Stuay at the 34 Chemo ite pane : LeJoancakrdS.K.MaSncdheulz,anP,hWo..5..Mpm4s. January, 1989 03143 HorHaIity Sy at the 3 Chemotite Plans Introsuetion rorveeEr:OsMBIeMCIESiovteh cwoansorctompalrettaeldityin s1t9u8s0y. ofThtehepu3rpoCsheenosfticneepsreaumgsy 5v1cagottage rSHeTRIeCTAmTIEnley{1Gethreemnortafrlaintythexapeerxipeenccteedofinem4locyoemeasraastiethsisomtpraanmssons.us sig ORIEL 247 20 T7O0 WN CUBE of Sy, arth marized in sng emlcyees aurnepiortw,asSssstunetdtsinctFaenbtrluyaryreogfe1n580, hn expected. TSon ITe0RTESUaATSNs 36t,e19S84o,r4ticoentwraecrtiewanscensSthiiouwsnes13<003.upeSapceecssteicaittyn, 55 sstuesy 104 Cony he WIR Stats of a) SUEISHICH alysis contucies HTIETETE Case former mioyees so determine if vould here be was asconcanmes amy signifi . rPeTsuElts0of$0theSTfoAllDowuBpOSpotUfIuAdcSyeI.notnh. amToantgs CshuepmecrlisperesPehnatns tohpetemyeetehosdsenseng cor Hetnoss [TPhICIBEEY ESRSr.lorThees50wa0reofsethnetsiaatl 1 IncEine she was sum as those wethsaes to cesermin he vines 10 the vasof ET0EAAre SSeIcGeNnFscIepTdlC,eansateesex.acneaoslbsytezaseinhecmoaprysaolfissyheacseashto caeerssetrtmiicnaesesfeo.esostehere or aetietencies among Chumoniee pra employees compared to tne general population, ae 03144 ! . TTFheeTIsEntSiuTtdiyaS)ipxosptmuunlaatythis(onneu3tw,a6ss8h8ed)eCfwhieensmeodulpiadtsaetaepldllatnhoeo.uirlnTychleuemerp:olsotyeeresofwneompwleoryeeeemsplforyoea Le ne employees mire since the first study was conguctecs PY AVAILABLE terminated (deceased, retired, laid-off, sisaslec, on Teave, study. Siteee]lsynaAtuIsnIaSsSractesieornmin(e5sA)f,orth4e11attiraocntsi!veDeesmephloTyneoeesx t(hMr0o1)ugansgecsrretacing of inaivicuals wisse status could not be resolved by Ssh or oi, Toofnor AhugeustSsC13e,rS1a9i8m4e,nta request was sent of vil status. tAoppSrSoAvarleqwuaes.stirnegcefavefdoromnal Geatgarpeeerment N1o5v0es1d9e8r8,1,an19884.comTphueserrestualptes cwoenrteairneitnugrn2e,d66o8n rMeacrocrhas19w,as15s0hsi.spes to SSA on in ABUSE of TON as 1980, received request for siaflar on Bxtaser 1, 1984 services was sent to uot, and 4 comuter ape was snipped CERT 29, 1984. The results were received Novenser 20, 1504, FIontns TeCtpt of the results CHEER YET requested from state of the health SSA nd M01 deparsments searches, dent cereey. for 411 former copteye 6 X10 or professions] presumed to be dens. nosologtst accoroing Death to the certificates were cos Efghtn Reviston of the by 5 Internations] Classification of Diseases. 2 03145 : : ! Employees for whom no vital stasys information was availadle were ingiviguregistration, former employers, church affiliations ang unions. ERAS Sats re hanes frm 0.5, seu ns was elevated and controls were four employees individually matches to the . Ire NSE of Cos ns corres var sts se see Sro2 e51s08rL5TRoSoherfeissn.(e0r0Vaamt1ssaa8c.s6e8rrreeteu)rssr wavonpo 10 SLT ns 1 ty 3) va sre cre ones oSoehsAr7esm.0nlSr5at0onfnr ceCoorfenseevnenfosras+esosnyrsep death which occurred in SouthAnerica, BESATvaOn apPe C03146 o es.tSocuocrotrteosaowsroanatsrsmen. deaths froo all causes, 0.54, (953 C.L. = 0.37, 0.76) for deatns due to TsRAE e orn cnondromsf2rs4eteseea" rs 0 0 Coan) ny secs tr mt a, prostatic cancer deaths in the entire study Population. For eachdeath - BESTCOPY AVAN ABLE 02147 Discussion I 0 rr cy . tm BESTCOPY AVAILABLE : 03148 tFFhRoaPrtEeCwTpeErrSeev4ac0lodenndt(u2c)itne2dM.Cihnannecseotfaintdhianng tshuee U.tSo. thsengTatrrgaes nuhmiegrheorf rcaotmepawroiusolnspe SThCe EconFclourslifoneybawsaesd eovnidtehnits asmtoundgy e1m5pltoayteesnpatstCahteimsotliictael.ly significant "6 03149 L a D oi aRE0 1i cure, nm SONwIetig f(aa)l, I ee, Toom e e OIDD HC Cnn mn (iggy. TI n1 e wsa 100s sn papa or RE LL h Doo mee E S= mmeocinenwesonyaemmriiveost Te wow wm gE reli a ann CoeDD os DDN EE I mn in, oe oe 3 Com no - a2 nudes ace A rr Ce er ee 8 yo r nrch Ny O iris tn pig a no mts mCowo0nneaTL ee w LT o Dhl "on em - Pon a am Mm Httre sa rm a rr I Com ee 1--oro--we sccins 8 a a - lEnLSI IPA. moe gm = Dawe lo gEB 15 3 HRCHT Cu {a eG dec Es Sm el EEE, en mn rt nn EE Dom ee 2ew pe oo oe I tt a tt rt. ia I l TE0.141. rwegs , 14 CH nih 18. sry 1 ME Dome D " ome. - mo. " De ee mm .- Smo CN tt sry ome "8 32 mea sn Dome UE a "includes dup cate To em a 8 ~ | E m e RTT e IES LLEInDnnn ono 1CmanEmmrwaric maar -- or an re - a erm e 11rey a on ev eT [r-- Cm Coen Toth em ee ee oe eee A tL CLoom mm e ee w nLn Lm 3 --asecoames m 4g roommnn 8 Ee p mEoEw NE = EoBg BESTCOPY AVAILABLE H 03154 } I ln EAA Ss 1 cot smss nan 0 tm, . BL trema ea n LR------ & mnSe Doo 1 nmwa I m lw 8 HC try yy. or ary ernaare) Aorv--------. Bm ne a Domo mm Btw tp ares 5 EmC aioorr mcr ypArran = womner 15. orate PgAerauney I ran ny ee se re TDomoeel MEA Coe rgg PRATdaseeming LT -- MY E on ee a Mm ee - pe Dome ID toe ten a, - wr - toe eeee v-e vi- h-in PM en ee - ee re ttrr ts-- em en DJ oe 190 CHE or orn egg EE nig ay a4-22 [1 tmrinte st[-- DDDooowrmeoa anee 08 CHER 0 SUimmen (yyy. rrveiaey toe To a, "ar hin ee na rn wm is in i. tw rs mr me YL Arete cues wear 1So mong Come ome a Somme . mew a, EE " 8 nlm Domo mono SB mI --ma e0%e 2 oo.rom wmmn 1a ive oven1 rom ap- I . tamer ed S 5 m tte etme aatpergony c e TR ew BE = s l m me ms onep, to o mea ee gn- EmCSme memt CCoomwoee nen 3a fd 030 1I rymmae inwe crim tesa &a8 s vot opmm1r srscamp DLE om - aey Dn Cooaen eme ImL en TALE sew 0 Eaecicy cans ny EI mAnOILILD MATTE art (Gy wie Coe et oc em ee tr tn. rr tr = oyeHmEIR M0 4018 gy et gi mm mmme E = et e ee FBEOLoIsImiTmE. = en r iry a on ms 3i'Aemeen or one 4 I a, Pomona I C CeoCnsE el ] w mem etwn en en . -- hn P nmm e DPowmeey ee . Sa Co am m mm oee an Pann tM ee ee -- a ie er, TG wy ma a : 2vetrrans rr oman se oDoomme lWmD lm ew 1 ro OAa tesaee e pm T Ss ra rymary tCm o rn eepa er er tg, Coa wmm maw anew on ew Le Coen mone $PoFem LlM n hee Sn er vrmesi po 1 a ea t tse tonmeei mama og YoA w ln em Dome al DEE ome lo Ireenetr 1% 8e31p me t 5 xchsor eu &&8 LLE om an ==| me "om : un | UNIVEOFRMSININETSOTYA || ovtenrgrarmers Phenies | BSo2ax0aO1io9lo7aMrwaairysaoesuHonori Mimeapors Mimesoa 55455 April 6, 1989 SLtaarfrfy RP.hysZiocbiealn, M.D. M3ediCceanlteDrepartment S2t2.0-P2a6u-l0,2 Mi 55144-1000 Dear Larry; MybEieinntcnhlieonssttoheetedraprMpeirltaneetnadeessescoaptfuraitiniodporouptsuthloleyat1tib9ao5eb9ncl..aeusseDAcesoaontftIhasmithneeinanmtgoiunongncteehdretaorinenstutylhtesretgeoaflredptihhnoegnec.tohmeptahroiessonmist 41 states; therefore, the U.S. rates may be motrhee asptpurdoyprcioahtoer.t occurred in ApthsreeyvoituowouswilclyolmwphasireiceshofnurssoemdistthehfoertUa.pbSrl.eoss,traatttiehcse.craenTschueelrtsownhlaiyrcehcoswniesmiisaldtaderrnettsosfeitdnhdosiinengopubrneetsweenetned ewtImhanpesiltoieayaneltseitsrar.etepicosFortuhtiro.ctrahtle.lFryomrosHroicewga,ennvcieenfrroi,'csaoinftnthgitlsehexewcaedsssiistgeneos(wttSiiMtvRfhe=oi1unn7od6r,gaann9so5n%gaCndthep.<o1Crli0Lit9no,inceau2ln60bt)ihveirfeeojron wnaostinegleviastetdhe sfuagcgtesttihnagt chemical exposures. tthheaste tahries wnaost psirtoebsabltyypidtcuheaellTgyoascathsrasonoiccneti.eastteidAnlawelithwtoreeesr If you have any questions please feel free to call me at 626-4810. Youss-sincerely, sociS.ateMaPndreolf,essPohr.D. HEALTH sCiEncEs 03159 IE 8 9G5 EPERSCENT0COCFXICDIECEED(CBLoEIANATTESSD1000CMTAAiENE,SS0DS0TTRAAeMDIEvRAiOTLeHZsER.DiemoklaTrAaLITeYiasr?t (sSyi,on 3 wwe we ww ou 33 $ || mmecesnor svcsni csnesenesn snes et nces of seT en 105sa-- re LC i acthofPuR sats sso 7 se a Ccheeeeofr asnsES1 o(192s55rr vcmaraee)rrs e acto sae 15-100 mnt ac oa r rieeccoossaek [pe ------ mn cueetaren ses ann T as rstT 1ssome CPoeeen o ae oan nLn D on wB= Pe oCwt ae eeem es eame nm waan ee em = E=B P TSo M waom aean wwaa Pen an ee wn L o"gy f 8 ee Coen em am mew Coea n ae aL we Sen ww am em ew Cen am ee me CCeenm aemm eeee ame aeew RE| tho -- nese ss ae ay a OWL ternTc cues eee en nous I sts 0 Cnr rr MLL BISEASES of nervous Syston a aseonus I INWQUE mewaTIC Meant Drsease nsaronaarey ry eAoAtaASEtnAS Lsesriosnos oosr cts n mrs marttktemtrcmeemeseerrsovmemmce RSPTS3t(-19t58s-a15o5r5mmocuenreasrey ma coe TTI.SUT, 1 seriescontnan Cw Poe em an eew eeae 3 Ce' on o.SE 3g g 2 "oan EO -- 3 an Mem ap a =] 3 ne re Toes g=E Pos"oee ew aw gg ae 1 oe E ww E= 8 nC sPweMao LaanE nmee ownamEE.ge c Ccoomomn al l nnome m mwah 1k a om wu oeom BEST COPY AVALIBLE 023162 " TABLE 6. 9O5BSEPERRVCEEDNTANCDONEFXIPGEECNT(CECEDIBLDAIERMAEITDTHSS0RBYoWiCiAOnUnESEs,oSToyuSnTnbAtNDtwARaDcsIZaoEs,DsyMpOoRrTeAsLITlY eRAaTIrOSfom()9.) Q3 3 Sa UE a mtv chs sm etn ssmre J ew -- cSLuLeCAsoRrLsorentervtsormains 393 en Bow an de oe ee u CLaEme Poem a ew am om wo 2 =| Len mew aw ae ecaeres cas or spsentoscmnesc es s ssn vemos on cursor xs ste |fonven mw w an n am ew LDeuns ewnm eeem asmm eem A ee svt cranny oneen 950-108 ary aeea tonsen ips ussecr--riea | ccnturs atime TIO OISE4ses (1350-1943 ay) - --r Ol o ion t en mst vise estas o Ce Cssreettes ttm epnap:c sontmesormarons sesSES (1925-1930 somccures > eonween 0 13135or cr mpeg LJ" rere or Bisesses or me sea mt srseases or 7 See rio rete sure 1 srsseen Poen m cut ssor Tem eae ew ag,- o Too re am gg CE 2 as =22 Pam- aE a E) - e PM ee aw yn C Coelmm e B now moe se oy = cnmEoumLo nogog TorEneem aegm ah en = = Tome wa JD Doe ww WI omen ae 00 2 on SB em an ga Hem em ew ge Cem mm em \ EE Le 1 ES \-- 5 z coz165