Document BVBbeB0pvByjqQQJ4G3n1p9w

r j TIIj I TALLY k a i l . API:IL 2 7 t h , 1 9 LG SKIN TESTS WITH ETHYL. LEAD WITHSTANDS WASHING. lead exposure before conception, the mother will oome to full term and the offspring will be normal. This is in. ac cord with our records among painters and othor lead workers who contract lead Gl PER CENT. ABSORBED IN 5 MINUTES. poisoning in mild form. My own work indicates that with very small doses there aie apparently no ill effects in the first generation from one or The following is the fourth section more leacied parents. But if the off- spring ,is given the same small exposure,' of the medical report on ethyl petrol the effect is, very apparent in the second which kas been prepared for " The Daily Mail " by Dr. Myer Coplans, D.S.O., and third'generations. In fact, we have considerable trouble in getting enough animals to -pair off. This observation O.B.E., the eminent research worker. It holds in spite lof the fact that the animals is based on his own personal experiments and data supplied by the Research Asso ciation of British Motor and Allied Manu are given; the proper food to provide the vitamins required. If the mother is leaded, you will always find lead in the foetus and in the ETHYL ON THE SKIN facturers, who carried out a scientific baby animals. To my thinking this analysis of exhaust gases from motor' engines. . The first, second, and third sections shows one of the dangers that exists from or : so-clld .non-industrial lead ex posures. . EXPERI M EN T S. W ASHING W ITH OIL '; INEFFECTIVE. _ ,; were published on Monday, Tuesday, The- following experiments which 1 The fourth instalm ent of the report and yesterday. have carried out with ethyl petrol indi on ethyl petrol, prepared on behalf of cate some of its dangers. * The Daily Mail by Dr. Myer Coplans, By DR. M YER COPLANS, D.S.O. 1. Skin absorption test #(persona!). (a> D.S.O., and published to-day in Page 6, W ith regard to the action of ethyl Ethyl petrol was poured on to the skin petrol, special interest attaches to the report by Dr. Frederick B. Flynn who, of the arm and allowed to evaporate. Tmmediately on drying, the, patch of skin deals with experiments to discover the effects of washing the skin after this petrol has been allowed to dry upon i t Points are: , 5'. on behalf of the Columbia University, was well rubbed with a piece of linen carried out af the request of the Medical Committee of the Ethyl Gasoline Cor poration an investigation as to the fol saturated with a known quantity of kero sene. (b) . The . experiment was repeated on * another skin area,- but cleansing of the lowing risks :-- * . skin; ws delayed until five minutes* in 1. The possible hazard that( might arise from splashing the ethyl gasoline (1,000 to 1 mixture) on;the person; or from the terval had elapsed: after the evanoration was ,completed and the skin had appar ently become dry. Ethyl petrol was poured onv to the-skin of the arm and allowed to evaporate. Immediately on drying the patch of skin was well rubbed with a piece of linen saturated with a known quantity of kerosene. ' .. Result: Tlie skin of the arm had ab sorbed .54 milligrams (49 per cent.) of the lead tetraethyl present in the* ethyl ; cleansing of the hands or clothes by the Two blank tests were carried out for .petrol applied (Ice.) immediately . on/ ; i j mechanic or by the housewife; or while adjusting the carburettor or cleaning out the gasoline line r tank, etc, the estimation of lead kerosene used. in the linen and ;2. The possible danger from the inhala tion of ethyl gasoline iuiiies from spill Two cntro! experiments were also carried out at blopd heat, lead-free age in the ghrage and other1placs when glazed, porcelain being substituted for drying. '1 Washing the skin with kerosene to the extent indicated appears to be an ineffec tual measure for the purpose of remov i n g , contamination of lead tetraethyl caused by contact, with ethyl petrol. vaporisation may take place. LEA D ST ORED I N BODY. The results of th e investigation, which was carried out on animals, bear out those th at have already been described in similar circuhistanees by observers using various leajd! compounds and, in the .area M skin on which the ethyl petrol was: allowed to evaporate. R e s u l t : The - skin of the arm had absorbed .54 milligrams (49 per cent.) of the lead; ietraethyi present in the ethyl petrol applied (Lee.) immediately on drying and .67. milligrams (61 per cent.) in 5 minutes. The final instalm ent of Dr. Coplans*s report will be published to-morrow. . No experiments on animals were car ried out by Div Coplans during his in-, vestigations for The Daily Mail. - The references in his report relate to the experiments, of other authorities. addition, it is! plain that animals exposed Washing the skin with kerosene to the to skin applications of ethyl petrol; will extent indicated .appears to be an in store head.' He concludes : effectual measure for the purpose of re The fact to bear in mind is that thero moving' contamination of lead tetra is no]| doubt that a storage of lead takes ethyl caused by contact with e th y l place;i under exposure. Leali stored in petrol. . I the f>ody constitutes a potential lead poisoning. The same observations that can bip made about.animals receiving skin ) applications cnln be made on the animals that were exposed to the fumes of dilute ethyl 'gasoline. , It Is of significance thaV there , is a continuous stbfag of lead taking place in the animals, no matter whether it ils by absorption through th skin or by' in halation. Wihat is of special significance, or what seenis so to us, is the fact jtha't the animals in thjj gas chamber seem to show the effects niore quickly than tlfiose which; received skin applications. 'The dilution does: not 'seem to Ui(ike any; dif ference except for! the longer: time neces sary to accumulate the same quantity of lead. Two'personp who followed the work since tjhe beginning and whq had taken precautions, knowing the poisonous nature of the compound, have stored lead shown b, examination of the excretion from the bowel and kidney. DR. F L Y N N 'S CO M M UNI CAT I O N Dr. Flynn, writing to me on Mairoh 21, 1928, from the Department of Physio logy, College, of Physicians and `Sur geons, Columbia University, New York, states the following:-- * , stIdniethiass^ctouitnhtrey a.wtno^ihsativeesrmofadaebosretvioenrasl. r miscarriages, and ! sterilitv among lead workers. My own unpublished studies in dicate;, and confirm the observations: of others that fh,e organs themselves are not hurt, ^>ut that the effect is on the Icell itselt. '. 1 < If you take the animal away from the N 5823 Hh 0001284