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FILE NAME State of the Art Literature SAL DATE 1949 July DOC SAL046 DOCUMENT DESCRIPTION Journal Article - Asbestosis and Cancer of the Lung ot ew awe re or The Am300j Am300j ' Am300j Journal the the 1945 ke The Medical Medical Association American Medical Medical Medical o29 of the Board Trustees BALI hnOpe Trustees 0, CALTIMORE RONG Published ww Published COME COME DURO i> CIRCUIT COME CALTIMORE CALTIMORE | COME Auspices CHICAGO : Itrrnors CHICAGO CHICAGO CHICAGO ILLINOIS ILLINOIS ILLINOIS Association 1949 1949 1949 ARTHRITIS ARTHRITIS and Differential Diagnosis Diagnosis Developments Developments Developments Therapy Ph.D. ROSENBERG New practitioners Incidence of rheuma Chicago Chicago in this so Incidence Incidence of rheumatic rheumatic country is to Incidence Incidence rheumatic diseases this country is small proportion high attention specialists specialists of come to the attention attention In most instances instances ffaomrilydpihaysgicnioanssis treatment treatment treatment remains impor- utmost impor- an forms infections typhoid SPECIFIC ARTHRITIS From numerical numerical From constitute of view specific of of - arthritis arthritis constitute a small proportion proportion run of arthritis arthritis commonly ran tered gonorrheal gonorrheal arthritis and arthritis associated arthritis tuberculous staphylococ- and arthritis infections Arthrits streptococcic streptococcic staphylococpneumococcic Arthritis syphilis meningitis brucellosis typhoid pneumococcic >? oss today Articular disorders encountered coccidioido- coccidioido- rare pper mycosis although often encountered appear be aaore spreading America America encountered appear to be @peee where Gonorrheal Among drugs important arthritis instances continue to hold imporitantmportant of gonorrheal arthritis decreasing gonorrheal gonorrheal infection of place The incidence significantly significantly since discovery of sulfonamide penicillin OF be in when OF red at s fy, se, , . "a> PRees _ the practitioner observations report describing alterations alterations have logic significance describing tissues alterations these gross and microscopic microscopic microscopic appearances those tissuesfamiliar terms also frequently frequently familiar clinicians commonly European European which commonly discuss these diseases using differ from those used in To America some extent confusion confusion until To research disclosed probably continue for until rheumaticdiseases for would presently Until unknown causes Until that however , be very useful uniformn terms would employed be very who deal could rheumatic employed patients patients rheumatic A committee committee classification matism Association Association has The laboratory diagnosis in many instances establishing this diagnosis depends instances Prompt OKLA recognition more gonorrheal arthrito is n than knowledge the laboratory laboratory OKLA in actual patients Affected disease usually febrile the onset The articular articular phenomena often ushered with with migratory as in phenomena generally generally migratory migratory migratory rheumatic fever are causes As rule must with pre- in be sumptive diagnosis diagnosis gonorrheal gonorrheal based analysis of arthritis behavior Neisseria diagnosis articular disease disease genital secre- Lous, 1948 from om the aLod uis Read Nov. Louis Louis Nov. Session interim interim 1948 Session th the American Medical <American Medical Association, Se. om ad at 27039 27039 f ~~ occurs only fourth from evidently are evidently evidently excluded excluded synovial conse- quence quence barrier from synovial synovial lining lining menibranes of arthritis has been cor- If a diagnosis diagnosis gonorrheal gonorrheal promptly rectly rectly made the should cured penicillin by adequate doses gonorrheal Supposed Supposed failures reflect Many penicillin therapy in gonorrheal arthritis arthritis reflect merely gonorrheal infection appreciation effectiveness effectiveness of gonorrheal gonorrheal gonorrheal provoking stirring latent rheumatoid provoking onset " resistant arthritis arthritis " Penicillin rheumatoid gonorrheal arthritis provoked actoivityftacetivnity proves to rheumatoid gonorrhea arthritis millions units even millions units penicillin penicillin will significantly 759 millions. of activity by the Lonorrhea. significantly ee units Of penicillin will Not of ma - etron. SUILe the ae mw > ~ MEN . Unai rezengy, on ThA per. -the assieniipticzs WAL oy THOTE than five tines 220 225 tron strike lin usme > Un regent regent on grammei .. = -------- ce assumption assumption cas ---- T my rs eeby : Renetti Renetti mys more five Renetti Renetti Renetti * * biologic biologic purposes Renetti physicians pi Renetti pi a ace underestiymoatueng - grave underestimate underestimate - bertubing bertubing cer- necropsies per ASBESTOSIg A Until CANCER CANCER coexistence ASBESTOSIS ASBESTOSIS AND recently coexistence THE LUNG asbestosis and can- and investigators investigato rs ath 6r 2) ons suspected . 2: in phys~das 4. Ceesargsinally Cnfortunately for phys~dasphys~das ba, sed 7 Cnfortunately Cnfortunately ' rentgen gas assumption 4 bat were Cnfortunately limite the pas: t Once as unwitting ue been assumption vee radium understanding injured injured ge adequate d^' ; dostic ~ ne methods 35S had Furthermore understanding understanding dostic Furthermore unsatisfactory unsatisfactory of interaction The neutrons unsatisfactory unsatisfactory mechanism mechanism interaction FraTmhee s componeres The biologic :weed roeigen An understanding understanding understanding of radiation with the case Frames important electrons electrons which electrons matter matter biologic mys the at high egy given egy electrons Ps Fny Sered Sered through tht eiriesns erugey collisionThese biologic mattteur m, = However in Esipate sing chemical chemical alterations relatively relatively the small gratedany cell one electron energy dis- ee any the case neutrons the energy principally hydrogenous component of a ated collision with protons protons thus component ated tissue The speed speed energy length of thsugh a cell large amount one unit proton hisre energy it Thus destruction = There through through permanently permanently rays are tfective jure permanently evidence roentgen roentgen relatively while inmire the There There only against dividing cells biologic neutrons praluced biologic efective efective at phase phase aay, mayquantitatively effects injure injure neutrons neutrons effects effects quantitatively The qualitatively qualitatively different from the roentgen plored field qualitatively qualitatively relatively sicists Lina piored field evident experience experience experience Ay In broader broader tremendous responsibility engineers volvingon hysicists to the physicist itthagencies devolving those their - whco oncerned he agencies exploring supporting frontiers frontiers Seices. It is ith exploring not enough dismiss responsibility danger implications uh the mere siences warning warning that > danger neutron neutron extrapolate, ith extrapolate mere was done Sdermate extrapolate implications implications extrapolate analogies biologic wounknownsdequate unknowns should subjected to investigation allel with arallel with physical implications implications Sor. oyual interrelations interrelations During caused deaths either Were the lungs 17.2 per lung 22 (172 distribution cancer at reported & Some * . = . Se Neutron .: Neutron June Mice SFT L-78S (huned 771-785 Neutions Fast Neutions wesof Fast Joses of Fast Neutions Evans Specific Mice Radiolog , Radiolog jg 30; 2iLe34 tsiector orice 1941 med, Wehne e of M., and Factones for 70eenkre ues, Ltschr.f Sorge, A; Krebsforsch. 5 1 ba: toreh Stationery 199). Asbeststauh im ~) - 1220 CURRENT COMMENT Aug. exogenous origin represented by the inhaled asbestos dust was responsible for the bronchial cancers observed Since some 20,000 workers are employed in the asbes- producing industries of this country and Canada and many additional thousands in various asbestos- consuming industries increased attention to this probable occupational hazard of cancer of the lung by the medical profession is desirable Cytologic examinations of the bronchial secretion may well be included in the periodic examination of workers exposed to asbestos dust whenever clinical or roentgenologic evidence indi- Foley's patient who was an alcohol addict there we changes indicating a late stage of chronic glomerul nephritis and death occurred with the uremia Such changes in the kidney are spyemrhpatposms interpreted as accidental direct necropsy findings witho relationship to the syndrome under discussi A disease in rabbits apparently analogous to that nonsuppurative panniculitis in man has been describ by Reynals and others The cause of Web Christian's disease is unknown 2 cates the possible existence of a pulmonary cancer As the available evidence shows that the occurrence of cancer of the lung is related to pulmonary asbestosis and is not merely a possible sequela of exposure to asbestos dust in all fatal cases of asbestosis there should be postmortem examination with detailed histo- logic analysis The anatomic lesions produced by asbestos dust in the lungs make difficult at times distinction by clinical and roentgenologic diagnostic methods between changes of pneumoconiotic nature and those that might indicate a cancerous growth CRISIS IN SCIENTIFIC RESEARCH . Further evidence that the medical profession mu coordinate and intensify its protection of the right carry on experimental studies on animals in labor tories is provided in a report on this type of legislatio in the District of Columbia Representatives fro twenty national health and science hospitals lay groups and governmental aggreonucipess. hloac united behind Senate bill 1703 providing for labor tory use of the 7,000 to 10,000 unclaimed dogs no destroyed each year in the District pound The as frenzied distortion and political pressure by antiviv sectionists have placed the bill in jeopardy according : the National Society for Medical Research Current Comment NODULAR PANNICULITIS CHRISTIAN DISEASE Christian's discase or nonsuppurative nodular panniculitis is characterized by recurring episodes of fever and the development of numerous painful and slightly tender subcutaneous nodules In only 3 of 33 recorded cases was death apparently due to the disease In the case reported by Kritzler in which necropsy was done the nodular lesions were limited to the subcutaneous fat However fat emboli were society quotes Dr. A. C. Ivy its secretary to the effect that members of the special Senate com mittee to which the bill was referred are personally i favor of it but the bill probably will not be reporte out Dr. Ivy has issued an appeal that interested sons write letters of endorsement to Senator J. Howaperr McGrath of Rhode Island who introduced the mea sure and Senator Margaret Chase Smith of Main chairman of the subcommittee Some such concerts t action is necessary at state as well as national level to beat back efforts of a small misguided group obstruct the advancement of science <fl < found in the lungs and there was widespread acute . necrosis of the liver and spleen In the case examined at necropsy by Spain and Foley necrotic areas were found not only in the subcutaneous fat but in the mesenteric omental and pretracheal fat Fat emboli were not found in the lungs nor were areas of necrosis observed in the liver or spleen However foci of fat pancreas necrosis were present in the region of the A third case investigated at necropsy was that of Mostofi and Engleman in which nonsuppurative pan- niculitis involved the skin the epicardium and the peri- pancreatic periadrenal perirenal and mesenteric tissues The nodules in the fat are of variable appearance The earliest lesions consist of small accumulations of laden macrophages Later there are some- what larger lesions that present small areas of central necrosis in the immediate vicinity of which are lympho- laden cytes polynuclear leukocytes and macro- the phages In still older nodules necrotic material is decreased or absent and the lesions are partially or completely replaced by fibrous tissue In Spain and 1. Kritzler .: A Case of Christian's Disease Proc New York Path Soc 1940-1941 p 47 2. Spain D. M. and Foley J. Non Sup urative M Suppurative Paniculits Panniculitis Am 1. Path 201703 1945 > | FIRST TELEVISION NETWORK HEALTwHea SHOW ~-. : The first health education program ever prese on a television network was viewed and heard fre the NBC studios in Radio City New Yea June 16. Transmitted as far west as Chicago & program titled Your Good Health and the Migh Atom was arranged through the Bureau of He Education of the American Medical Association Hami produced under the supervision of Mrs. Hami Hester radio coordinator for the Bureau The F gram dealt with the use of radioisotopes in medic particularly radioactive iodine Dr. Paul C. eben Chief isotopes Division United States A Energy viewed Commission Oak Ridge Tenn was i by an NBC announcer on the principle 4 radioactivity With a Geiger counter specially radioacti fied Dr. Aebersold demonstrated first how radiopaatcitenit can be traced and atoms identified Later a with furnished by Dr. Sidney C. Werner Columbia Co of Physicians and Surgeons and Presbyterian Hos he demonstrated concentration of radioactive iodine iodine the thyroid aoe