Document BRVVnBO22x2qd7nQ1R7rpLzmk

Dr. v. B. Ackart Union Carbide plastics Company River Road Bound Brook, Row Jersey Rr. T. A, PeVllbiss Hr. p. p. Dexter Dr. A* V. Downss Nr. J. J. Click Hr. a* T. Scribe Dr. H. P. Smyth, Jr. August 6, 1959 VBA-3037 Plastic Oral Thermometer Dear Dr. Ackarti Vs have no actual data on the weight of the rigid vinyl flla in tho oral thermometer but believe It would bo very little. You state that a residual solvent (75 nethyl ethyl ketone and 25% toluene) would amount to around 5 to 7% of the filu weight, this residual solvent la believed to bo primarily toluene. Toluene la a material of relatively low oral toxicity. our laboratories found it to have an ZDsq dosage of 7.53 grans per kilogram body weight for the rat. Xn the customary use of an oral thermometer, the toluene would extract very slowly from tho film. X do not think that it would bo haaardoua to utilise VBA-3037 In the manufacture of oral themoaetersj this should bo a safe application. Yery truly youra. Thomas V. Bala, R. B tUPXCAL 0XMCTQB ucc 063600 INTERNAL CORRESPONDENCE BAKE LITE COMPANY DIVISION OF CORPORATION RIVER ROAD, BOUND BROOK, N. J. T (Nam*) Campaaf lutllM Capr < Dr. T. W. Nale^ra- Union Carbide Pias'fcdcs Co. New York, New York v'i-~ ,, 0l* August 5, 1959 Origlualiflg 0pl. Development 4nnrr/ng Utt*r d<of Dr. C. C. Mr. W. B. Mr. T. A. Mr. F. D. Dr. A. W. Mr. J. J. Mr. G. T. Dr. H. F. Cooper/ Tibbets - BB DeVilbiss - BB Dexter - BB Downes - Rm. 1103 Glick - 30 E. Scriba - Rm. 1901 Smyth, Jr. - Mellon Swbjtcf Taylor Instrument Company has developed a plastic oral thermome ter based upon VBA-3027 which is described in the attached Report of Call by H. R. Melin. VBA-3027 is an unplasticized cast vinyl and we have a letter of no objection for foods from Dr. Lehman. The formulation consists of VYNS 98% and G-62, 2%. However th film is cast from a solvent mixture of 75% methyl-ethyl ketone and 25% toluene. Residual solvent varies from 5 to 7% in the 5 mil. film to be used and this is believed to be primarily tolu ene. The fabrication process utilizes heat and pressure and we anticipate further solvent loss. We would appreciate comments from you and/or Dr. Smyth concern ing the safety of this application. WBA/bk p .o, W. B. Ackart "RECE.VED AUG 6 1959 atmcill! ( ucc 063601 MM >7* Ocearml Salt* Copy I.T > Oonsral File Copy Regional Jfenager's Copy Regional File Copy Salesman BAKEUTE COMPANY REPORT OF CALL Division No. Region 3 IMS. Taylor Icatronent Company $5 AmeTstreet .rr--f Rochester. Sew York rciWlEWVD vt ttixjo. tfr. Richard galrille R. R. Mblln BY- Date op Call. 7/9/59 Last Call. CONFIDENTIAL- ian es in Personnel. *, .'' * Bales Bulletin. : I: : Mr. J. V. McLaughlin, W' Mr. A. R. Bullamn^BB^ Mr. T. Ao DeVUblsa, BB Jh*. W. C. Quinby, RI . t , For several year* ^hla oo^ary has bean working on the development of an oral thermometer fabricated fro* plastic film. In tha fabrication of tills .thermometer, a piece of plastic fll* Is pressure jforned with several avail capsules* These oapsnlea are then filled *11$ a fatty add, each oeltlng at a vary specific teaser*turei; Over tha top of'tha formed another place of the' earn fll* la dielectrically sealed* Maiy months ago samples of VBA-3300 Batnral .003 " were checked, bat It vms not possible to obtain a good dielectric' sealo A short tine ago this problem was reviewed, end It was suggested that a sample of our o005" rigid oast film be evaluated since thickness vAs an t^ortant factor In dielectric sealingo Ramples of our VBA-3027' 1ft In thickness of e00$" wav submitted and these hat* been pressure formed with excellent results, end initial dielectric eealing teste have been Mtiafactocy. This fabrication work Is being done for subject by PLaxaII. He believe that the Increased thickness has contributed to the good dielectric sealing, but also important Is the fact that the frequency on the dielectric machine has been increased from 27 aaga- qyeles to eonewbare in the vicinity of 60 megacycles. At this point, Mr. Melville la quite encouraged about the possibility of using our rigid oast film In this application, frevlously a Oenothera 00-120 was the only film that locked aa though it might do a satisfactory Job. Oar VBA-3027 It an FDA approved material, but my conoem at the sonant is whether or not the residual advent in this film might cause complications as far as FDA approval is aonoaxuad. Pgl . T. A. DWELBISS ^ 7s-t IX ' 'if/*'-- v. /.p*e it r*/r.v J1 Bullmen infermed as that our VBA-3027 in a thickness of .005" has a residual solvmit tq> to 7K. Gould it be determined whether or not this would be sufficient to c ease rejection by FDA* j Wnllman has also suggested the use of our VCAB-3605 Vt for this same application. This letter ocvposnd has not ywt been made In a 5 mil thickness and when this is available samples BUI be previdedt Mr. Melville for evaluation* RLCHIVE This application still looks very promising, and, according to Mr. Melville, their sales departesnt Is Just as enthusiastic as ever. ar UJ 6 is 2BU2rt?m . ------------- ucc mrwM wci:** 'K0L0GY DUAtt 063602